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postsurgical vomiting

Gildasio S De Oliveira, Jane Bialek, R-J Marcus, Robert McCarthy
STUDY OBJECTIVE: Diphenhydramine is an antihistamine with previously demonstrated analgesic and antiemetic properties. However, it is unknown if the beneficial perioperative properties of diphenhydramine can translate to a better quality of postsurgical recovery. The main objective of the current investigation was to investigate dose-ranging effects of diphenhydramine on quality of recovery after surgery. SETTING: Tertiary hospital in the United States. DESIGN: A prospective, randomized, double-blind trial...
November 2016: Journal of Clinical Anesthesia
Ron Schey, Mohammed Saadi, Deena Midani, Aaron C Roberts, Rahul Parupalli, Henry P Parkman
BACKGROUND: There is increased awareness about risks and benefits of using domperidone to treat gastroparesis. AIM: To describe the outcome of treating patients with refractory gastroparesis symptoms with domperidone. METHODS: Domperidone 10 mg QID or TID was prescribed to patients with refractory gastroparesis symptoms; follow-up obtained at 2-3 months assessing symptoms and side effects. Patients filled out Patient Assessment of Upper GI Symptoms prior to treatment and at follow-up along with Clinical Patient Grading Assessment Scale (CPGAS, +7 = completely better; 0 = no change)...
August 16, 2016: Digestive Diseases and Sciences
Walavan Sivakumar, Heather S Spader, Eric Scaife, Robert J Bollo
The authors present the first case of a Cushing ulcer in an infant with medulloblastoma who, despite being administered stress ulcer prophylaxis, worsened after corticosteroids were initiated. An 8-month-old boy presented with progressive vomiting, lethargy, and decreased oral intake. Imaging revealed a heterogeneous fourth ventricular mass. Preoperatively, the patient was started on dexamethasone. The patient underwent an uncomplicated external ventricular drain placement and suboccipital craniotomy for resection of the lesion...
April 2016: Translational pediatrics
Jay A Redan, Tina Wells, Sandra Reeder, Steven D McCarus
INTRODUCTION: Opioids are commonly used in the postoperative period to manage postsurgical pain. However, adverse side effects of opioids include respiratory depression, urinary retention, pruritus, vomiting, nausea, constipation, and increased risk of falls. Surgical site infiltration with extended release liposomal bupivacaine is effective in the multimodal care plan of managing postsurgical patients. The purpose of the present study was to examine the possible effects of liposomal bupivacaine on postoperative opioid adverse events following open hernia repair and laparoscopic colon resection surgery...
April 2016: Surgical Technology International
Tommaso Borracci, Daniela Prencipe, Anita Masotti, Alessandra Nella, Germana Tuccinardi, Lucia Margiacchi, Gianluca Villa, Fulvio Pinelli, Stefano Romagnoli, Angelo Raffaele De Gaudio, Giovanni Zagli
BACKGROUND: The benefits of an Acute Pain Service (APS) for pain management have been widely reported, but its diffusion is still limited. There are two APS models: anesthesiologist-based and a nurse-based model. Here we describe the development of a different APS model managed by anesthesia residents, and we report the first year of activity in a tertiary Italian university hospital (Careggi University Hospital, Florence, IT). METHODS: Patients were included in the APS were those undergoing abdominal and urologic surgery causing moderate or severe postsurgical pain...
2016: BMC Anesthesiology
Husam H Balkhy, Susan Arnsdorf, Dorothy Krienbring, John Urban
OBJECTIVE: Despite the advantages of robotically assisted cardiac surgery over conventional open sternotomy, robotically assisted surgery may be associated with substantial postsurgical pain arising from multiple incisions and access ports. This single-site, retrospective chart review evaluated the impact of liposome bupivacaine compared with bupivacaine HCl on postsurgical pain management in patients undergoing robotically assisted endoscopic cardiac surgery. METHODS: Sequential patient cohorts undergoing robotically assisted cardiac surgery received either 0...
November 2015: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
Jared Klein, Kathryn Baxstrom, Stephen Donnelly, Patrick Feasel, Paul Koles
A 46-year-old woman presented to two emergency departments within 12 hours because of acute abdominal pain. Physical exam demonstrated tenderness and epigastric guarding. An ultrasound was interpreted as negative; she was discharged home. Later that evening, she was found dead. Postmortem exam revealed acute hemorrhagic necrosis of a segment of jejunum secondary to volvulus. Clinical clues suggesting presentations of small bowel volvulus are usually nonspecific; the diagnosis is typically confirmed at surgery...
2015: Case Reports in Medicine
David M H Lam, Siu-Wai Choi, Stanley S C Wong, Michael G Irwin, Chi-Wai Cheung
The efficacy of pregabalin in acute postsurgical pain has been demonstrated in numerous studies; however, the analgesic efficacy and adverse effects of using pregabalin in various surgical procedures remain uncertain. We aim to assess the postsurgical analgesic efficacy and adverse events after pregabalin administration under different surgical categories using a systematic review and meta-analysis of randomized controlled trials.A search of the literature was performed between August 2014 to April 2015, using PubMed, Ovid via EMBASE, Google Scholar, and ClinicalTrials...
November 2015: Medicine (Baltimore)
Ying Mao, Yu Yao, Li-Wei Zhang, Yi-Cheng Lu, Zhong-Ping Chen, Jian-Min Zhang, Song-Tao Qi, Chao You, Ren-Zhi Wang, Shu-Yuan Yang, Xiang Zhang, Ji-Sheng Wang, Ju-Xiang Chen, Qun-Ying Yang, Hong Shen, Zhi-Yong Li, Xiang Wang, Wen-Bin Ma, Xue-Jun Yang, Hai-Ning Zhen, Liang-Fu Zhou
BACKGROUND: The radiochemotherapy regimen concomitantly employing temozolomide (TMZ) chemotherapy and radiotherapy (RT) 4 weeks after surgery, followed by 6 cycles of TMZ is a common treatment for glioblastoma (GBM). However, its median overall survival (OS) is only 14.6 months. This study was to explore the effectiveness and safety of early TMZ chemotherapy between surgery and chemoradiotherapy plus the standard concomitant radiochemotherapy regimen. METHODS: A randomized, parallel group, open-label study of 99 newly diagnosed GBM patients was conducted at 10 independent Chinese neurosurgical departments from June 2008 to June 2012...
October 20, 2015: Chinese Medical Journal
Abdullah S Terkawi, Siny Tsang, Daniel I Sessler, Rayan S Terkawi, Megan S Nunemaker, Marcel E Durieux, Ashley Shilling
BACKGROUND: While most trials of thoracic paravertebral nerve blocks (TPVB) for breast surgery show benefit, their effect on postoperative pain intensity, opioid consumption, and prevention of chronic postsurgical pain varies substantially across studies. Variability may result from use of different drugs and techniques. OBJECTIVES: To examine the use of TPVB in breast surgery, and to determine which method(s) provide optimal efficacy and safety. STUDY DESIGN: Mixed-Effects Meta-Analysis...
September 2015: Pain Physician
Lucas J Castro-Alves, Andrea Cristina Pereira Oliveira de Medeiros, Saulo Pimentel Neves, Camila Lucena Carneiro de Albuquerque, Norma Sueli Modolo, Vera Lucia De Azevedo, Gildasio S De Oliveira
BACKGROUND: Postsurgical quality of recovery is worse in female than that in male patients. Duloxetine has been used successfully for the treatment of chronic pain conditions, but its use for preventing acute postoperative pain has been limited to a single previous study. More importantly, the effect of preoperative duloxetine on global postoperative quality of recovery has yet to be evaluated. The main objective of the current investigation was to evaluate the effect of perioperative duloxetine on postoperative quality of recovery in women undergoing abdominal hysterectomy...
January 2016: Anesthesia and Analgesia
Brian M Ilfeld, Eugene R Viscusi, Admir Hadzic, Harold S Minkowitz, Michael D Morren, Janice Lookabaugh, Girish P Joshi
BACKGROUND: Liposome bupivacaine (Exparel) is a multivesicular liposomal formulation of bupivacaine currently approved in the United States for single-dose administration into the surgical site to provide postsurgical analgesia. This retrospective analysis examined safety data from clinical trials involving the off-label use of this formulation in peripheral nerve blocks. METHODS: Data from 6 controlled (phases I-III) studies were compiled involving single-injection ankle, femoral nerve, and intercostal nerve blocks (2 each)...
September 2015: Regional Anesthesia and Pain Medicine
Jad M Abdelsattar, Amy C Degnim, Tina J Hieken, Michel Saint-Cyr, Judy C Boughey
Mastectomy with immediate tissue expander reconstruction is associated with postoperative pain, nausea, and vomiting. Various techniques of perioperative and postoperative pain control have been described. Our standard of care for postsurgical pain management in patients undergoing mastectomy with immediate tissue expander reconstruction has been preoperative ultrasound-guided paravertebral block. Recent literature demonstrating the opioid-sparing benefits of liposomal bupivacaine has directed two of our plastic surgeons to pilot its use in immediate tissue expander reconstruction...
October 2015: Annals of Surgical Oncology
U von Arnim
Gastroparesis is characterized by a constellation of upper gastrointestinal symptoms in association with delayed gastric emptying in the absence of mechanical outlet obstruction from the stomach. Major symptoms are nausea, vomiting, early satiety or postprandial fullness, bloating, and abdominal or epigastric pain. Idiopathic, diabetic, and postsurgical causes represent the most common etiologies. Diagnostic procedures for the evaluation of gastroparesis comprise gastric emptying scintigraphy (gold standard), (13)C-octanoate breath testing, and a wireless motility capsule...
June 2015: Der Internist
Karen L Carr, Faith E Johnson, Charbel A Kenaan, John M Welton
PURPOSE: Postoperative nausea and vomiting (PONV) remains one of the most common postsurgical complications after anesthesia and surgery. Pericardium 6 (P6) stimulation is believed to prevent PONV and is a potential adjunctive treatment with pharmacologic agents. The purpose of this study was to compare the effects of P6 stimulation on PONV occurrence to a control group not receiving the P6 stimulation in sequential female patients undergoing laparoscopic cholecystecomy at a community hospital in central Florida between November 2010 and March 2013...
April 2015: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
Nathalie Rochet, Katja Lindel, Sonja Katayama, Kai Schubert, Klaus Herfarth, Andreas Schneeweiss, Christoph Sohn, Wolfgang Harms, Juergen Debus
INTRODUCTION: A prospective study to assess toxicity and survival outcomes after intensity-modulated whole-abdominal irradiation (IM-WAI) following surgery and adjuvant intravenous carboplatin/taxane chemotherapy in advanced FIGO stage III ovarian cancer. PATIENTS AND METHODS: Between 2006 and 2009, 16 patients with optimally resected FIGO stage III ovarian cancer, who had received six cycles of adjuvant carboplatin/taxane chemotherapy were treated with consolidation IM-WAI...
July 2015: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Pankaj Jay Pasricha, Henry P Parkman
Gastroparesis is a chronic symptomatic disorder of the stomach characterized by delayed emptying without evidence of mechanical obstruction. Symptoms of gastroparesis include nausea, vomiting, early satiety, postprandial fullness, and upper abdominal pain. The 3 main causes are diabetic, postsurgical, and idiopathic. Diagnosis is confirmed by demonstrating delayed gastric emptying. Gastric emptying rates measured by gastric motor testing generally correlate poorly with symptoms and quality of life in patients with gastroparesis...
March 2015: Gastroenterology Clinics of North America
Chao-nan Zhang, Xue-kuan Huang, Yan Luo, Juan Jiang, Lei Wan, Ling Wang
OBJECTIVE: To observe the clinical effects of acupoint injection of metoclopramide for postsurgical gastroparesis syndrome (PGS). METHODS: A total of 46 patients with PGS(from abdominal surgery) were randomly divided into control and acupoint injection groups (n=23 in each group). Patients of the acupoint injection group were treated by injection of Metoclopramide (5 mg+ normal saline) into bilateral Zusanli (ST 36) and Weishu (BL 21) alternatively, while patients of the control group treated by injection of 10 mg of Metoclopramide into the deltoid muscle and gluteus maximus muscle alternatively...
October 2014: Zhen Ci Yan Jiu, Acupuncture Research
V Martinez, L Guichard, D Fletcher
The role for tramadol in multimodal postsurgical analgesic strategies remains unclear. We undertook a systematic review to evaluate the utility of combining tramadol with morphine after surgery. We searched the MEDLINE, EMBASE, LILAC, Cochrane, and Clinical Trial Register databases for randomized, controlled studies comparing tramadol with placebo or active control in patients undergoing surgery. Fourteen studies (713 patients) were included. There was a limited but significant postoperative morphine-sparing effect, with a weighted mean difference (WMD) of -6...
March 2015: British Journal of Anaesthesia
J Sehouli, A Reinthaller, C Marth, D Reimer, T Reimer, W Stummvoll, L Angleitner-Boubenizek, B Brandt, R Chekerov
BACKGROUND: This is the first study investigating the safety and efficacy of the trifunctional antibody catumaxomab administered i.p. at the end of cytoreductive surgery and postoperatively prior to standard chemotherapy in patients with primary epithelial ovarian cancer (EOC). METHODS: Patients received i.p. catumaxomab 10 μg intraoperatively and 10, 20, 50 and 150 μg on days 7, 10, 13 and 16, respectively, postoperatively. After the study, patients received standard chemotherapy and were followed for 23 months...
October 14, 2014: British Journal of Cancer
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