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J M Lai, F Q Wu, Z X Zhou, X Y Yuan, G X Su, S N Li, Y C Yan, J Zhu, M Kang
Objective: To evaluate the utility of magnetic resonance imaging (MRI) in diagnosis of juvenile dermatomyositis and polymyositis (JDM-PM) in children. Method: Fifty-four patients with JDM-PM in the active stage were enrolled in the study group. Twelve patients with benign acute childhood myositis and forty patients with juvenile idiopathic arthritis (JIA) complicated with myositis were enrolled as controls. MRI imaging of thighs was performed in all patients, fast spin echo T1WI, T2WI, and STIR were obtained in all patients...
October 2, 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
J P Liu, H Wang
Prostate cancer, especially castration-resistant prostate cancer (CRPC) with its very poor prognosis, quite difficult treatments and urgent need of new theraputic strategies has become a serious problem of men's health in our country. Recent studies have shown that prostate cancer cells can stimulate the immune response; therefore, immunotherapy has become one of the hot spots in the treatment of CRPC. Cancer vaccines including polypeptide vaccines, nucleic acid vaccines, whole cell vaccines and autologous dendritic cell vaccines have been in stage Ⅱ or Ⅲ clinical trials, and will have good application prospects...
October 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Giulia Donvito, Jenny L Wilkerson, M Imad Damaj, Aron H Lichtman
Chemotherapy-induced peripheral neuropathy (CIPN) represents a serious complication associated with antineoplastic drugs. Although there are no medications available that effectively prevent CIPN, many classes of drugs have been used to treat this condition, including anticonvulsants, serotonin and noradrenaline reuptake inhibitors, and opioids. However, these therapeutic options yielded inconclusive results in CIPN clinical trials and produced assorted side effects with their prolonged use. Thus, there is an urgent need to develop efficacious and safe treatments for CIPN...
November 2016: Journal of Pharmacology and Experimental Therapeutics
Ping Wang, Yong Li, Huiqiong Nie, Xiaoyan Zhang, Qiongyan Shao, Xiuli Hou, Wen Xu, Weisong Hong, Aie Xu
BACKGROUND: Vitiligo is a common acquired depigmentation skin disease characterized by loss or dysfunction of melanocytes within the skin lesion, but its pathologenesis is far from lucid. The gene expression profiling of segmental vitiligo (SV) and generalized vitiligo (GV) need further investigation. OBJECTIVE: To better understanding the common and distinct factors, especially in the view of gene expression profile, which were involved in the diseases development and maintenance of segmental vitiligo (SV) and generalized vitiligo (GV)...
October 2016: Journal of Dermatological Science
Jinfeng Jiang, Xinjun Wang, Xiaojing Wu, Zhi Yu
Moxibustion is an important component part of Traditional Chinese Medicine (TCM). Among differ- ent kinds of moxibustion methods, thermal stimulation seems to be a pivotal impact factor to the theraputic efficacy. Based on its thermal characteristic and treated area-skin, we hypothesize that the thermosensitive TRPV channels may involve in the mechanism of moxibustion. This study, by referring to various experimental and clinical data, analyzes the properties and features of transient receptor potential vanilloid (TRPV) subfamily 1-4 and the impact of moxibustion on these channels...
April 2016: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
Lewis E Zionts, Michael H Jew, Kathryn L Bauer, Edward Ebramzadeh, Sophia N Sangiorgio
BACKGROUND: The Ponseti method has become the standard of care for the treatment of idiopathic clubfoot. A commonly reported problem encountered with this technique is a relapsed deformity that is sometimes treated in patients older than 2.5 years by an anterior tibial tendon transfer (ATTT) to the third cuneiform. Presently, there is insufficient information to properly counsel families whose infants are beginning Ponseti treatment on the probability of needing later tendon transfer surgery...
July 2, 2016: Journal of Pediatric Orthopedics
Gopinath Kasetty, Emanuel Smeds, Emelie Holmberg, Louise Wrange, Selvi Adikesavan, Praveen Papareddy
BACKGROUND: Tissue factor pathway inhibitor-2 (TFPI-2) is a serine protease inhibitor that exerts multiple physiological and patho-physiological activities involving the modulation of coagulation, angiogenesis, tumor invasion, and apoptosis. In previous studies we reported a novel role of human TFPI-2 in innate immunity by serving as a precursor for host defense peptides. Here we employed a number of TFPI-2 derived peptides from different vertebrate species and found that their antibacterial activity is evolutionary conserved although the amino acid sequence is not well conserved...
2016: BMC Microbiology
Thanh Xuan Nguyen, Lin Huang, Mario Gauthier, Guang Yang, Qun Wang
Oral delivery via the gastrointestinal (GI) tract is the dominant route for drug administration. Orally delivered liposomal carriers can enhance drug solubility and protect the encapsulated theraputic agents from the extreme conditions found in the GI tract. Liposomes, with their fluid lipid bilayer membrane and their nanoscale size, can significantly improve oral absorption. Unfortunately, the clinical applications of conventional liposomes have been hindered due to their poor stability and availability under the harsh conditions typically presented in the GI tract...
May 2016: Nanomedicine
Blair Williams, Benjamin A Taylor, Neil Clifton, Manohar Bance
BACKGROUND: Eustachian tube dysfunction (ETD) is a common medical issue, occurring in at least 1% of the adult population. Patients suffering from ET dysfunction typically present with complaints of hearing loss or sensation of pressure or plugged ear, which can lead to impaired quality of life. Over time ETD can result in conductive hearing loss or choleastatoma formation. Effective theraputic options for ET dysfunction are few. Eustachian tube balloon dilation is a novel surgical technique being used to treat ETD...
February 12, 2016: Journal of Otolaryngology—Head & Neck Surgery
Natalie Cosgrove, Ali A Siddiqui, Charles A Kistler, Andrew Zabolotsky, Saad S Ghumman, Umar Hayat, Sobia N Laique, Muhammad K Hasan
BACKGROUND: Our aim was to evaluate the efficacy, safety and long term outcomes of endoscopic mucosal resection (EMR) of large non-ampullary duodenal polyps. METHODS: A retrospective review of patients undergoing EMR of non-ampullary duodenal polyps ≥ 10 mm in size was performed. EMR was performed using standard snare polypectomy using pure coagulation current. Patient demographics, polyp site and histopathology, resection technique, use of adjunctive argon plasma coagulation (APC) ablation, adverse events, and residual/recurrent neoplasia at follow-up were evaluated...
June 2016: Minerva Gastroenterologica e Dietologica
Arun Sharma, Sanjeev Kumar
Left ventricular outpouchings commonly include aneurysm, pseudoaneurysm, and diverticulum and are now being increasingly detected on imaging. Distinction between these entities is of prime importance to guide proper management as outcomes for these entities differ substantially. Chest radiograph is usually nonspecific in their diagnosis. Echocardiography, multi-detector computed tomography evaluation and angiography are helpful in the diagnosis with their inherit limitations. Cardiac magnetic resonance imaging (MRI) is emerging as a very useful tool that allows simultaneous anatomical and functional evaluation along with tissue characterization, which has diagnostic, theraputic and prognostic implications...
December 2015: Cardiovascular Diagnosis and Therapy
Barry M OConnor, Pavel B Klimov
Some classifications recognize a number of species in the scab-mite genus, Psoroptes, mites that are of considerable importance in livestock production and veterinary medicine. However, modern studies suggest that populations from some host species are not morphologically or genetically distinct, creating taxonomic confusion with older names, which treated mites from different hosts as separate species. We review the taxonomy and nomenclature of the genus and the two oldest binomens, most recently known as Psoroptes ovis and Psoroptes equi...
July 2015: Experimental & Applied Acarology
Chunmei Chen, Yuncheng Xia
OBJECTIVE: To determine the factors associated with the eff ect of steroid on adult primary nephrotic syndrome. METHODS: The general information, laboratory examination and renal pathological type of 425 patients with primary nephrotic syndrome were retrospectively analyzed. RESULTS: Th ere were significant differences in the response to steroid among the pathological types of minimal change disease, focal segmental glomerulosclerosis and IgA nephropathy...
January 2015: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Lu Yang, Hai Y Liu
Endometriosis is one of the major female health burdens which affects the quality of life and reproductive potential of individuals. Although some treatment strategies are available, the complete cure of endometriosis is not yet possible. Investigation of new and alternative strategies for endometriosis treatment thus remains necessary. Identification of small RNA molecules and their roles in gene regulation and other cellular functions has revolutionized modern biomedical science. Several micro RNAs (miRNAs) and short interfering RNAs (siRNAs) have been found to be associated with endometriosis progression...
December 2014: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Qi Wang, Ming Zhang, Dian Huang, Yu Zhou, Tong Qiao
OBJECTIVE: To investigate the theraputic effects of carotid endarterectomy (CEA) on cognitive function in patients with carotid stenosis (CAS) and congnitive impairment. METHODS: CEA was performed on 38 patients with CAS from December 2011 to July 2013. There were 26 male and 12 female patients, with an average age of (70 ± 7) years. Patients was underwent neuropsychological examinations (NPEs) including Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) at 1 week before and 6 weeks after treatment...
August 2014: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Lingzi Xia, Yangwu Ren, Xue Fang, Zhihua Yin, Xuelian Li, Wei Wu, Peng Guan, Baosen Zhou
BACKGROUND: The morbidity and mortality of cancer increase remarkably every year. It's a heavy burden for family and society. The detection of prognostic biomarkers can help to improve the theraputic effect and prolong the lifetime of patients. microRNAs have an influential role in cancer prognosis. The results of articles discussing the relationship between microRNA polymorphisms and cancer prognosis are inconsistent. METHODS: We conduct a meta-analysis of 19 publications concerning the association of four common polymorphisms, mir-146a rs2910164, mir-149 rs2292832, mir-196a2 rs11614913 and mir-499 rs3746444, with cancer prognosis...
2014: PloS One
Philippa M Beard, Samantha J Griffiths, Orland Gonzalez, Ismar R Haga, Tali Pechenick Jowers, Danielle K Reynolds, Jan Wildenhain, Hille Tekotte, Manfred Auer, Mike Tyers, Peter Ghazal, Ralf Zimmer, Jürgen Haas
Vaccinia virus (VACV) is a large, cytoplasmic, double-stranded DNA virus that requires complex interactions with host proteins in order to replicate. To explore these interactions a functional high throughput small interfering RNA (siRNA) screen targeting 6719 druggable cellular genes was undertaken to identify host factors (HF) influencing the replication and spread of an eGFP-tagged VACV. The experimental design incorporated a low multiplicity of infection, thereby enhancing detection of cellular proteins involved in cell-to-cell spread of VACV...
2014: PloS One
Qi Wu, Han-Dong Wang, Yong Sam Shin, Xin Zhang
Dural ateriovenous fistula (DAVF) at the craniocervical junction is rare. We report a patient presenting with brainstem dysfunction as an uncommon onset. Brainstem lesion was suggested by magnetic resonance image study. Angiogram revealed a DAVF at a high cervical segment supplied by the meningeal branch of the right vertebral artery, with ascending and descending venous drainage. Complete obliteration of the fistula was achieved via transarterial Onyx embolization. Clinical cure was achieved in the follow-up period; meanwhile, imaging abnormalities of this case disappeared...
March 2014: Journal of Korean Neurosurgical Society
G M Schulz
A speech production impairment can occur following damage to either the left or right hemisphere. The nature of the impairment, however, differs depending on which hemisphere is damaged and within the left hemisphere, whether the damage is to the anterior or posterior language areas. This paper reviews the recent literature on the types of speech production impairments that follow damage to the left and right cerebral hemispheres. Damage to the left hemisphere anterior language area causes primarily a phonetic impairment, i...
1997: NeuroRehabilitation
Nian-Tang Yu, Wei Han, Ling Zhang, Ling-Ling Zhu, Qing-Wei Wang, Guo-Qing Zhang, Bai-Yun Liu
OBJECTIVE: To assess the clinical efficacy of acupuncture pretreatment for the prevention of stroke based on promoting the circulation of the Governor Vessel and regulating mentality, and explore its effect mechanism. METHODS: Seventy cases of transient ischemic attack (TIA) were randomized into an acupuncture group (35 cases) and a western medicine group (35 cases). In the acupuncture group, acupuncture therapy of promoting the circulation of the Governor Vessel and regulating mentality was applied at Yaoyangguan (GV 3), Mingmen (GV 4), Zhiyang (GV 9), Shenzhu (GV 12), Dazhui (GV 14), Yamen (GV 15), Fengfu (GV 16), Baihui (GV 20) and Neck-Jiaji (EX-B 2)...
November 2013: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
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