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https://www.readbyqxmd.com/read/29145336/expression-of-hormone-receptors-in-low-grade-adenosquamous-carcinoma-of-the-breast-a-case-report
#1
Hai-Bo Wu, An-Li Zhang, Wei Wang, Heng Li
RATIONALE: Low-grade adenosquamous carcinoma (LGASC) is a rare subtype of metaplastic breast carcinoma which is generally recognized as a characteristic subgroup of triple-negative breast cancers previously. However, in this study, we reported for the first time a case of LGASC with hormone receptors expression. PATIENT CONCERNS: Pathological analysis of breast tumor specimen obtained by a 42-year-old female patient was performed. Morphologically, it composed of glandular structures with scattered squamous differentiation accompanied by haphazard arrangement of spindle cell stroma...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143395/a-novel-classification-scheme-to-decline-the-mortality-rate-among-women-due-to-breast-tumor
#2
Bushra Mughal, Muhammad Sharif, Nazeer Muhammad, Tanzila Saba
Early screening of skeptical masses or breast carcinomas in mammograms is supposed to decline the mortality rate among women. This amount can be decreased more on development of the computer-aided diagnosis with reduction of false suppositions in medical informatics. Our aim is to provide a robust tumor detection system for accurate classification of breast masses using normal, abnormal, benign, or malignant classes. The breast carcinomas are classified on the basis of observed classes. This is highly dependent on feature extraction process...
November 16, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29142588/characterization-of-hormonal-receptors-and-human-epidermal-growth-factor-receptor-2-in-tissues-of-women-with-breast-cancer-at-muhimbili-national-hospital-dar-es-salaam-tanzania
#3
Amos Rodger Mwakigonja, Nyanda Elias Lushina, Ally Mwanga
Background: Breast cancer is a leading cause of morbidity and deaths among women worldwide. In Tanzania there is no published data on human epidermal growth receptor-2 (HER2/neu) expression in breast carcinoma. Hormonal receptors and HER2/neu status reportedly influence post-mastectomy adjuvant therapy and predict treatment outcome and prognosis. Here we evaluate hormonal receptors and HER-2 status in biopsies of women with breast cancer at Muhimbili National Hospital (MNH). Methods: A cross-sectional study of female breast post-modified radical mastectomy (MRM)/incisional biopsies confirmed to be carcinoma at the Histopathology Unit (January-December 2013)...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29142403/flavonoidal-constituents-antioxidant-antimicrobial-and-cytotoxic-activities-of-dipterygium-glaucum-grown-in-kingdom-of-saudi-arabia
#4
Usama Shaheen, Nagwa Abdelkader Shoeib, Abeer Temraz, Mohamed I S Abdelhady
Background: Dipterygium glaucum Decne. herb is one of the common traditional plants with multiple medicinal uses. Objective: To isolate the major constituents and to investigate the antioxidant, antimicrobial, and cytotoxic activities of this herb. Materials and Methods: Methanolic extract of D. glaucum herb was fractionated using n-hexane, dichloromethane, and n-butanol. Butanol fraction was chromatographed using column chromatography and preparative thin layer chromatography to isolate the major constituents...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142397/chemical-composition-antimicrobial-and-antitumor-potentiality-of-essential-oil-of-ferula-tingitana-l-apiaceae-grow-in-libya
#5
Waleed Elghwaji, Abeer Mohamed El-Sayed, Kadriya S El-Deeb, Aly M ElSayed
Background: Ferula tingitana L. (Apiaceae) has been considered to have abortive and menstruation-inducing properties. It used to treat sore throat, fever, indigestion, and pains. Objectives: The objective of this study is to establish the chemical composition of the essential oil of flower, leaves of F. tingitana, and to throw light on antimicrobial, cytotoxic activities of Libyan plant. Materials and Methods: The chemical composition of the essential oil of flower (0...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29141995/correction-breast-tumor-kinase-phosphorylates-p190rhogap-to-regulate-rho-and-ras-and-promote-breast-carcinoma-growth-migration-and-invasion
#6
(no author information available yet)
No abstract text is available yet for this article.
November 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/29141669/metastasis-in-the-mandibular-condyle-a-case-report
#7
Mina Dodo, Masahiro Kumagai, Yuta Kato, Hisashi Hirakawa, Takeyoshi Koseki
BACKGROUND: Most bone metastases are observed in the trunk of the body. Metastasis in the mandibular condyle is rare. In many case reports, temporary common temporomandibular joint disorder-like symptoms can be a sign of relapse and metastasis. CASE PRESENTATION: We report a rare case of breast carcinoma metastatic to the left mandibular condyle in a 55-year-old Japanese woman, who visited our department for a dental check-up prior to chemotherapy. She had almost no symptoms, but radiographs suggested the existence of metastasis...
November 16, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29140993/prognostic-significance-of-cyclin-d1-protein-expression-and-gene-amplification-in-invasive-breast-carcinoma
#8
Angela B Ortiz, Diego Garcia, Yolanda Vicente, Magda Palka, Carmen Bellas, Paloma Martin
The oncogenic capacity of cyclin D1 has long been established in breast cancer. CCND1 amplification has been identified in a subset of patients with poor prognosis, but there are conflicting data regarding the predictive value of cyclin D1 protein overexpression. This study was designed to analyze the expression of cyclin D1 and its correlation with CCND1 amplification and their prognostic implications in invasive breast cancer. By using the tissue microarray technique, we performed an immunohistochemical study of ER, PR, HER2, p53, cyclin D1, Ki67 and p16 in 179 invasive breast carcinoma cases...
2017: PloS One
https://www.readbyqxmd.com/read/29137334/the-coffee-diterpene-kahweol-enhances-sensitivity-to-sorafenib-in-human-renal-carcinoma-caki-cells-through-down-regulation-of-mcl-1-and-c-flip-expression
#9
Kyoung-Jin Min, Hee Jung Um, Jee In Kim, Taeg Kyu Kwon
Sorafenib is approved for the treatment of hepatocellular carcinoma (HCC) and advanced renal cell carcinoma (RCC). However, low tumor response and side effects have been widely reported. Therefore, to improve the efficacy of sorafenib, we investigated whether combined treatment with sorafenib and kahweol, the coffee-specific diterpene, has a synergistic effect on apoptotic cell death. Combined treatment with sorafenib and kahweol markedly induced caspase-mediated apoptosis in renal carcinoma Caki cells. Combined treatment with sorafenib and kahweol induced down-regulation of Mcl-1 and c-FLIP expression...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135722/assessment-of-biological-and-clinical-aggressiveness-of-invasive-ductal-breast-cancer-using-baseline-18f-fdg-pet-ct-derived-volumetric-parameters
#10
Gul Ege Aktas, Ebru Taştekin, Ali Sarikaya
OBJECTIVE: The aim of this study was to evaluate the relationship of baseline fluorine-18-fluorodeoxyglucose PET/computed tomography (CT)-derived volumetric parameters for the primary tumor with clinicopathological risk factors and molecular subtypes in patients with invasive ductal breast carcinoma (IDBC). PATIENTS AND METHODS: We evaluated 65 patients who underwent fluorine-18-fluorodeoxyglucose PET/CT for initial breast cancer staging. The association of maximum and mean standardized uptake values (SUVmax and SUVmean, respectively), metabolic tumor volume, and total lesion glycolysis (TLG) with clinicopathological risk factors and molecular subtypes was investigated and the discriminative power of significant features was assessed...
November 10, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29135534/the-multiple-faces-of-programmed-cell-death-ligand-1-expression-in-malignant-and-nonmalignant-cells
#11
Edwin R Parra, Pamela Villalobos, Jaime Rodriguez-Canales
Preliminary data suggest that tumor expression of programmed cell death ligand 1 (PD-L1) protein in human cancers, as determined by immunohistochemistry in formalin-fixed, paraffin-embedded tissue samples, may predict clinical response to anti-PD-1/PD-L1 therapy. PD-L1 is not a specific tumor marker and its expression is also observed in various nonmalignant cells, such as macrophages and lymphocytes, causing confusion in immunohistochemistry analysis when these inflammatory cells are overlapping with tumors cells...
November 13, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29135105/impact-of-abcb1-and-cyp2d6-polymorphisms-on-tamoxifen-treatment-outcomes-and-adverse-events-in-breast-cancer-patients
#12
Sona Argalacsova, Ondrej Slanar, Hana Bakhouche, Lubos Pertuzelka
PURPOSE: This study was designed to evaluate the effect of CYP2D6 and ABCB1 polymorphisms and co-medication on the outcomes and adverse events (AEs) of tamoxifen therapy. METHODS: In total, 258 women (187 postmenopausal and 71 premenopausal) with hormone positive breast carcinoma were retrospectively evaluated. CYP2D6 polymorphisms were evaluated with AmpliChip (Roche), and polymorphisms of ATP-binding cassettes B1 (P-glycoprotein) (ABCB1) rs2032582 and rs1045642 with restriction fragment length polymorphisms polymerase chain reaction (RFLP-PCR)...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29134954/completion-axillary-lymph-node-dissection-can-be-avoid-in-patients-with-invasive-breast-cancer-and-sentinel-lymph-node-micrometastases
#13
Calogero Cipolla, Giuseppa Graceffa, Sergio Calamia, Stefania Latteri, Marco Vito Marino, Mario Latteri, Salvatore Vieni
BACKGROUND: The prognostic value of sentinel lymph node (SLN) micrometastases in invasive breast cancer patients is still widely debated. Even if, in the absence of unequivocal guidelines, the axillary lynphadenectomy is not still performed in the routine clinical care of these patients. MATERIALS AND METHOD: We have retrospectively analyzed 897 patients with operable invasive breast cancer and clinically negative axillary lymph nodes underwent conservative surgery or total mastectomy with SLN biopsy...
November 14, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29132563/when-does-atypical-ductal-hyperplasia-require-surgical-excision
#14
REVIEW
Jennifer M Racz, Amy C Degnim
Atypical ductal hyperplasia (ADH) is a proliferative, nonobligate precursor breast lesion and a marker of increased risk for breast carcinoma. Surgical excision remains the standard recommendation following a core needle biopsy result consistent with ADH. Recent research suggests that women with no mass lesion or discordance, removal of greater than or equal to 90% of calcifications at the time of core needle biopsy, involvement of less than or equal to 2 terminal duct lobular units, and absence of cytologic atypia or necrosis are likely to have a less than 5% chance of a missed cancer...
January 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29132326/association-between-gene-expression-profile-of-the-primary-tumor-and-chemotherapy-response-of-metastatic-breast-cancer
#15
Cemile Dilara Savci-Heijink, Hans Halfwerk, Jan Koster, Marc Joan Van de Vijver
BACKGROUND: To better predict the likelihood of response to chemotherapy, we have conducted a study comparing the gene expression patterns of primary tumours with their corresponding response to systemic chemotherapy in the metastatic setting. METHODS: mRNA expression profiles of breast carcinomas of patients that later developed distant metastases were analyzed using supervised and non-supervised classification techniques to identify predictors of response to chemotherapy...
November 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29131529/clinicopathological-characteristics-and-survival-outcomes-in-pleomorphic-lobular-breast-carcinoma-of-the-breast-a-seer-population-based-study
#16
Li-Peng Yang, He-Fen Sun, Yang Zhao, Meng-Ting Chen, Nong Zhang, Wei Jin
The purpose of this study was to explore the clinicopathological features and survival outcome of pleomorphic lobular carcinoma (PLC) of breast, we identified 131 PLC patients and 460,109 invasive ductal carcinoma (IDC) patients in the Surveillance, Epidemiology, and End Result (SEER) database. PLCs presented with increased lymph node involvement, older age, higher AJCC stage and grade, and lower median survival months (PLC 84 ± 51.03 vs. IDC 105.2 ± 64.39 P < 0.01). Compared to IDC patients, PLC patients were more inclined to be treated with mastectomy...
November 13, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29130101/the-recombinant-egfr-cd13-bi-targeted-fusion-protein-induces-apoptosis-and-blocks-tube-formation
#17
Weijin Sheng, Jianhua Gong, Min Jiang, Yongsu Zhen
Previously it was shown that the recombinant EGFR/CD13 bi-targeted fusion protein ER(Fv)‑LDP-NGR which consists of an anti‑EGFR scFv antibody fragment, a tri‑cyclic NGR peptide, and a lidamycin-derived apoprotein, inhibited the proliferation of cancer cells and markedly suppressed tumor growth of breast carcinoma MCF-7 xenografts in athymic mice. This study investigated the mechanism of action of the fusion protein. Human breast cancer MCF-7 cells, lung adenocarcinoma A549 cells, and microvascular endothelial HMEC‑1 cells were used for a series of assays and determinations...
December 2017: Oncology Reports
https://www.readbyqxmd.com/read/29129494/osteoclast-like-giant-cells-in-invasive-breast-cancer-predominantly-possess-m2-macrophage-phenotype
#18
Ryuji Ohashi, Keiko Yanagihara, Shigeki Namimatsu, Takashi Sakatani, Hiroyuki Takei, Zenya Naito, Akira Shimizu
Breast carcinoma with osteoclast-like giant cells (OGCs) is a rare tumor; however, their clinicopathological aspects remain unclear. We described the clinicopathological characteristics of 8 patients with breast carcinoma with OGCs. Immuno-phenotypes of the OGCs were comparatively examined with that of foreign body giant cells (FBGCs) in 4 cases of granulomatous reaction (GR) without cancerous elements. In most cancers, tumors displayed cribriform and tubular growth patterns. Three cases showed moderate to high nuclear grade, while all the other tumors had low nuclear grade...
November 9, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29128601/isolation-modification-and-cytotoxic-evaluation-of-stilbenoids-from-acanthopanax-leucorrhizus
#19
Hao-Bin Hu, Hai-Peng Liang, Hai-Ming Li, Ru-Nan Yuan, Jiao Sun, La-La Zhang, Ming-Hu Han, Yun Wu
Twenty natural stilbenoids (1-20), including seven new stilbenoids (2, 4-7, 19, 20) and thirteen known stilbenoids (1, 3, 8-18), were isolated from the stem barks of Acanthopanax leucorrhizus, and six modified stilbenoid derivatives (1a, 2a, 4a, 4b, 7a and 17a) were obtained via methylation, demethylation and isopentenylation of the corresponding isolates (1, 2, 4, 7 and 17). These stilbenoids were structurally characterized by comprehensive analysis of their spectroscopic data and comparison with literature information, and evaluated for their cytotoxic activities against three human tumor cell lines (leukemia HL-60, hepatoma SMMC-7721 and breast carcinoma MCF-7) in vitro by MTT assay...
November 8, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29127249/-18-f-fdg-pet-ct-for-monitoring-response-to-therapy-of-choroidal-metastasis
#20
Naghmehossadat Eshghi, John Christoforidis, Phillip Kuo
A 38-year-old woman with metastatic breast carcinoma reported seeing "halos and flashes" in her left eye. Funduscopic exam revealed an elevated mass in the choroid of the left globe consistent with metastasis. Subsequent (18)F-FDG PET/CT revealed focal uptake in the nasal aspect of the left choroid of the eye corresponding to the mass seen on the funduscopic exam. Through correlation with the PET/CT, the lesion was retrospectively identified on the MRI. (18)F-FDG PET/CT post-radiotherapy showed complete response and thus supports that this imaging modality can be used for diagnosis and monitoring response...
November 10, 2017: Journal of Nuclear Medicine Technology
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