keyword
MENU ▼
Read by QxMD icon Read
search

"photodynamic therapy"

keyword
https://www.readbyqxmd.com/read/29156649/short-term-choriocapillaris-changes-in-patients-with-central-serous-chorioretinopathy-after-half-dose-photodynamic-therapy
#1
Marco Nassisi, Carlo Lavia, Camilla Alovisi, Luca Musso, Chiara M Eandi
BACKGROUND: Although photodynamic therapy (PDT) has become the standard treatment for central serous chorioretinopathy (CSC), its mechanism of action remains unclear. It is assumed that PDT induces short-term choriocapillaris (CC) occlusion and long-term choroidal vascular remodeling. In this paper, we describe the short-term CC changes induced by Half-Dose PDT (HD-PDT) in chronic CSC using optical coherence tomography-angiography (OCTA). METHODS: This is a prospective interventional case series...
November 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156351/benzamide-porphyrins-with-directly-conjugated-and-distal-pyridyl-or-pyridinium-groups-substituted-to-the-porphyrin-macrocycles-study-of-the-photosensitising-abilities-as-inducers-of-apoptosis-in-cancer-cells-under-photodynamic-conditions
#2
Devashish Sengupta, Zeaul Hoque Mazumdar, Avinaba Mukherjee, Debdulal Sharma, Amit Kumar Halder, Samita Basu, Tarun Jha
Amphiphilic porphyrin photosensitisers (PSs) having combinations of directly substituted pyridyl group(s) at the meso-position of a porphyrin macrocycle, and/or indirectly linked pyridyl groups as benzamide derivatives are reported. The compounds 5,10,15,20-tetrakis-(4-pyridylbenzamide)porphyrin (A.2), 5,10,15,20-tetra[N-(pyridine-4-yl)benzamidium] porphyrin (A.3), 5-mono-(4-pyridyl)-10,15,20-tris-(4-pyridylbenzamide)porphyrin (B.2) and 5-mono-(4-methylpyridinium)-10,15,20-tris-(4-pyridiniumbenzamide)porphyrin (B...
November 13, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29156346/abcg2-mediated-suppression-of-chlorin-e6-accumulation-and-photodynamic-therapy-efficiency-in-glioblastoma-cell-lines-can-be-reversed-by-ko143
#3
Sara A Abdel Gaber, Patricia Müller, Wolfgang Zimmermann, Dirk Hüttenberger, Rainer Wittig, Mahmoud H Abdel Kader, Herbert Stepp
BACKGROUND: Photodynamic therapy (PDT) of malignant brain tumors is a promising adjunct to standard treatment, especially if tumor stem cells thought to be responsible for tumor progression and therapy resistance were also susceptible to this kind of treatment. However, some photosensitizers have been reported to be substrates of ABCG2, one of the membrane transporters mediating resistance to chemotherapy. Here we investigate, whether inhibition of ABCG2 can restore sensitivity to photosensitizer chlorin e6-mediated PDT...
October 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29155337/photodynamic-therapy-in-fibrosarcoma-balb-c-animal-model-observation-of-the-rebound-effect
#4
Etcheverry María Eugenia, Pasquale Miguel Ángel, Gutiérrez Anabella, Bibé Solange, Ponzinibbio Carlos, Poteca Horacio, Garavaglia Mario
In vivo spectrofluorometric analysis during photodynamic therapy (PDT) is a fundamental tool to obtain information about the drug bleaching kinetics. Using a portable spectrofluorometer with an excitation source emitting at 400nm wavelength and a spectral analyzer ranging from 500nm to 800nm, the evolution of the meta-tetra(hydroxyphenyl) chlorin (m-THPC) photosensitizer fluorescence spectrum at the tumoral tissue of BALB/c murines with fibrosarcoma located at their flank was followed up. Ex vivo fluorescence measurements of the tumor and skin were also performed with the aim of better characterizing the in vivo signal at different parts of the tumor...
November 16, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29155073/dynamics-of-hpv-viral-loads-reflect-the-treatment-effect-of-photodynamic-therapy-in-genital-warts
#5
Zhili Hu, Lishi Liu, Wenjing Zhang, Hui Liu, Junpeng Li, Lifen Jiang, Kang Zeng
BACKGROUND: Photodynamic therapy (PDT) has demonstrated good clinical cure rates and low recurrence rates in the treatment of genital warts. Human papillomavirus (HPV) genotypes and viral load assays can reflect the status of persistent or latent infection and serve as a predictor of infection clearance. METHODS: Specimens from 41 patients with HPV infection were obtained, and the HPV genotypes and viral load were analyzed using real-time polymerase chain reaction (PCR) assays...
November 15, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29154833/photo-based-pdt-ptt-dual-model-killing-and-imaging-of-cancer-cells-using-phycocyanin-polypyrrole-nanoparticles
#6
Subramaniyan Bharathiraja, Panchanathan Manivasagan, Madhappan Santha Moorthy, Nhat Quang Bui, Bian Jang, Thi Tuong Vy Phan, Won-Kyo Jung, Young-Mok Kim, Kang Dae Lee, Junghwan Oh
Photodynamic therapy (PDT) and photothermal therapy (PTT) using nanoparticles have gained significant attention for its therapeutic effect for cancer treatment. In the present study, we fabricated polypyrrole nanoparticles by employing bovine serum albumin-phycocyanin complex and the formulated particles were stable in various physiological solutions like water, phosphate buffered saline and culture media. The formulated nanoparticles did not cause any noticeable toxicity to MDA-MB-231 and HEK-293 cells. The obtained nanoparticles effectively killed MDA-MB-231 cells in a dual way upon laser illumination, one is through phycocyanin propagated reactive oxygen species (PDT) upon laser illumination and in another way it eradicated the treated cells by converting optical energy into heat energy (PTT)...
November 14, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29154796/treatment-of-cancer-by-low-intensity-laser-radiation-therapy
#7
REVIEW
Sahar E Abo-Neima
Cancer treatment is one of the main challenges that face the scientific centers all over the world. The cancer incidence percentage increases year after year. The most used treatment for cancer is chemotherapy which is an application of systemic cytotoxic drug inside the patient. There are two main problems in chemotherapy that the cytotoxic drug is given systematically and cannot be localized in the tumor region in most cases that lead to killing the cancer cells as well as normal cells; and that cause the chemotherapy side effects like anemia, decrease in all blood cells count and platelets, nausea, vomiting, diarrhea, hair and nails loss and may cause a kind of blood toxicity...
November 14, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/29151826/renal-clearable-pegylated-porphyrin-nanoparticles-for-image-guided-photodynamic-cancer-therapy
#8
Liang Cheng, Dawei Jiang, Anyanee Kamkaew, Hector F Valdovinos, Hyung-Jun Im, Liangzhu Feng, Christopher G England, Shreya Goel, Todd E Barnhart, Zhuang Liu, Weibo Cai
Noninvasive dynamic positron emission tomography (PET) imaging was used to investigate the balance between renal clearance and tumor uptake behaviors of polyethylene glycol (PEG)-modified porphyrin nanoparticles (TCPP-PEG) with various molecular weights. TCPP-PEG10K nanoparticles with clearance behavior would be a good candidate for PET image-guided photodynamic therapy.
September 13, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29151775/the-application-of-antimicrobial-photodynamic-therapy-apdt-in-dentistry-a-critical-review
#9
E T Carrera, H B Dias, S C T Corbi, R A C Marcantonio, A C A Bernardi, V S Bagnato, M R Hamblin, A N S Rastelli
In recent years there have been an increasing number of in vitro and in vivo studies that show positive results regarding antimicrobial photodynamic therapy (aPDT) used in dentistry. These include applications in periodontics, endodontics, and mucosal infections caused by bacteria present as biofilms. Antimicrobial photodynamic therapy is a therapy based on the combination of a non-toxic photosensitizer (PS) and appropriate wavelength visible light, which in the presence of oxygen is activated to produce reactive oxygen species (ROS)...
December 2016: Laser Physics
https://www.readbyqxmd.com/read/29150040/management-of-malignant-lung-entrapment-the-oncothorax
#10
REVIEW
Roman Petrov, Charles Bakhos, Abbas E Abbas
Pleural metastasis is a common occurrence in up to 30% of patients with metastatic cancer. When lung entrapment and loculation of fluid occur, treatment is more difficult and we have named this condition "oncothorax." The malignant adhesions that entrap the lung in an oncothorax are not typically amenable to surgical decortication. The standard approach for managing these patients is to place an indwelling catheter. Other options may include pleurectomy and decortication, intrapleural hyperthermic chemoperfusion, and intrapleural photodynamic therapy...
February 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29147483/sonophotodynamic-therapy-mediated-by-liposomal-zinc-phthalocyanine-in-a-colon-carcinoma-tumor-model-role-of-irradiating-arrangement
#11
Maryam Bakhshizadeh, Toktam Moshirian, Habibollah Esmaily, Omid Rajabi, Hooriyeh Nassirli, Ameneh Sazgarnia
Objectives: Low penetration depth of light is the main defect of photodynamic therapy (PDT), which could be improved by sonodynamic therapy (SDT). In this study, a combination of PDT and SDT known as sonophotodynamic therapy (SPDT) was investigated using two reverse arrangements in CT26 tumor model. Materials and Methods: The liposomal zinc phthalocyanine was synthesized and characterized. It was then administered to CT26 tumor models as a sensitizer. The animal models were subjected to PDT, SDT, and the combined treatment in different groups...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29146972/specific-targeting-of-melanotic-cells-with-peptide-ligated-photosensitizers-for-photodynamic-therapy
#12
Paul Lorenz Bigliardi, Bhimsen Rout, Aakanksha Pant, Viknish Krishnan-Kutty, Alex N Eberle, Ramasamy Srinivas, Brendan Adrian Burkett, Mei Bigliardi-Qi
A strategy combining covalent conjugation of photosensitizers to a peptide ligand directed to the melanocortin 1 (MC1) receptor with the application of sequential LED light dosage at near-IR wavelengths was developed to achieve specific cytotoxicity to melanocytes and melanoma (MEL) with minimal collateral damage to surrounding cells such as keratinocytes (KER). The specific killing of melanotic cells by targeted photodynamic therapy (PDT) described in this study holds promise as a potentially effective adjuvant therapeutic method to control benign skin hyperpigmentation or superficial melanotic malignancy such as Lentigo Maligna Melanoma (LMM)...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29145577/photodynamic-therapy-leads-to-time-dependent-regression-of-pathologic-corneal-lymph-angiogenesis-and-promotes-high-risk-corneal-allograft-survival
#13
Yanhong Hou, Viet Nhat Hung Le, Thomas Clahsen, Ann-Charlott Schneider, Felix Bock, Claus Cursiefen
Purpose: Pathologic corneal (lymph) angiogenesis is a known risk factor for immune-mediated allograft rejections after corneal transplantation. However, there is no established treatment to regress pre-existing pathological corneal blood and lymphatic vessels. This study assessed the possibility to regress both vessel types by photodynamic therapy (PDT) after intravenous (i.v.) verteporfin injection, the influence of timing of PDT after verteporfin injection, and the effect on graft survival in high-risk keratoplasty...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29145431/effects-of-periodontitis-on-the-development-of-asthma-the-role-of-photodynamic-therapy
#14
Larissa Carbonera Candeo, Nicole Cristine Rigonato-Oliveira, Aurileia Aparecida Brito, Rodrigo Labat Marcos, Cristiane Miranda França, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari, Sandra Kalil Bussadori, Rodolfo Paula Vieira, Adriana Lino-Dos-Santos-Franco, Ana Paula Ligeiro-Oliveira, Anna Carolina Ratto Tempestini Horliana
To evaluate whether periodontitis modulates lung inflammation in an experimental model of asthma as well as the photodynamic therapy (PDT) is associated with a reduction of lung inflammation. Seventy-two BALB/c male mice (~2 months) were randomly divided into 8 groups (n = 9): Basal, Periodontitis (P), P+PT, P+PT+PDT, Asthma (A), A+P, A+P+PT, and A+P+PT+PDT. Periodontitis was induced by using the ligature technique and asthma was induced by ovalbumin (OVA). PT was performed with curettes and PDT with methylene blue (0...
2017: PloS One
https://www.readbyqxmd.com/read/29145103/gold-chlorophyll-a-hybrid-nanoparticles-and-chlorophyll-a-cetyltrimethylammonium-chloride-self-assembled-suprastructures-as-novel-carriers-for-chlorophyll-a-delivery-in-water-medium-photoactivity-and-photostability
#15
Vito Rizzi, Davide Vurro, Tiziana Placido, Paola Fini, Andrea Petrella, Paola Semeraro, Pinalysa Cosma
The stability of Chlorophyll a in water during prolonged exposure, at room temperature, to a neon lamp has been investigated by means of UV-vis and fluorescence spectroscopies. In addition, the Chlorophyll a (photo)stability evaluation in presence of suitable carriers has been performed in order to investigate its reactivity under the same conditions, for possible and future applications in Antimicrobial Photodynamic Therapy. Cetyltrimethylammonium chloride was chosen to solubilize Chlorophyll a in water. While, cetyltrimethylammonium chloride-capped gold nanoparticles offer a great opportunity because combine the Chlorophyll a action, used as a photosensitizer in Antimicrobial Photodynamic Therapy, with gold nanoparticles effect used in photothermal therapy...
November 9, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29144506/soluble-p-selectin-promotes-retinal-ganglion-cell-survival-through-activation-of-nrf2-signaling-after-ischemia-injury
#16
Kishan Kapupara, Yao-Tseng Wen, Rong-Kung Tsai, Shun-Ping Huang
Retinal ischemic injuries play an important role in the pathogenesis of several eye disorders. Inflammation and oxidative stress are key players in ischemic injuries. Following retinal ischemia, vascular endothelial cells and leukocytes express several inflammatory adhesion receptors, such as selectins and cell adhesion molecules. P-selectin stimulates leukocyte recruitment to platelet aggregates and has an important role in vascular homeostasis and inflammatory leukocyte extravasation. Soluble P-selectin can be neuroprotective through competitive binding to the receptors of endogenous P-selectin molecules...
November 16, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29143339/cell-death-pathways-associated-with-photodynamic-therapy-an-update
#17
David Kessel, Nancy L Oleinick
Photodynamic therapy (PDT) has the potential to make a significant impact on cancer treatment. PDT can sensitize malignant tissues to light, leading to a highly selective effect if an appropriate light dose can be delivered. Variations in light distribution and drug delivery, along with impaired efficacy in hypoxic regions, can reduce the overall tumor response. There is also evidence that malignant cells surviving PDT may become more aggressive than the initial tumor population. Promotion of more effective direct tumor eradication is therefore an important goal...
November 16, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29143338/extracellular-matrix-containing-in-vitro-three-dimensional-tumour-models-in-photodynamic-therapy-related-research
#18
Beata Čunderlíková
Three-dimensional (3D) tumour models have been intensively evaluated for their use in cancer research and there is a strong rationale behind using 3D cell cultures in photodynamic therapy (PDT)-related experimentation. In this contribution, it is explained why 3D cell cultures containing extracellular matrix (ECM) are preferred for this purpose. Results of experimental studies utilizing ECM-containing 3D cellular models in PDT research are summarized. Finally, design of in vitro 3D models that would provide clinically relevant information is discussed...
November 16, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29142997/advanced-smart-photosensitizers-for-more-effective-cancer-treatment
#19
Wooram Park, Soojeong Cho, Jieun Han, Heejun Shin, Kun Na, Byeongdu Lee, Dong-Hyun Kim
Photodynamic therapy (PDT) based upon the use of light and photosensitizers (PSs) has been used as a novel treatment approach for a variety of tumors. It, however, has several major limitations in the clinic: poor water solubility, long-term phototoxicity, low tumor targeting efficacy, and limited light penetration. With advances in nanotechnology, materials science, and clinical interventional imaging procedures, various smart-PSs have been developed for improving their cancer-therapeutic efficacy while reducing the adverse effects...
November 16, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29142604/klotho-expression-is-correlated-to-molecules-associated-with-epithelial-mesenchymal-transition-in-lung-squamous-cell-carcinoma
#20
Takayuki Ibi, Jitsuo Usuda, Tatsuya Inoue, Akira Sato, Kyoshiro Takegahara
Klotho is known as an anti-aging gene. We previously reported that the expression of Klotho is a postoperative prognostic factor for patients with lung large cell neuroendocrine carcinoma and lung small cell carcinoma. Recently, Klotho was shown to suppress the epithelial-mesenchymal transition (EMT). In the present study, we examined the association between the expression of Klotho and the regulation of EMT in lung squamous cell carcinoma. We immunohistochemically examined the expression of Klotho in patients with lung squamous cell carcinoma who had undergone surgical resection or photodynamic therapy...
November 2017: Oncology Letters
keyword
keyword
99238
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"