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https://www.readbyqxmd.com/read/28335344/a-targeted-nanoprobe-based-on-carbon-nanotubes-natural-biopolymer-chitosan-composites
#1
Baoyan Wu, Na Zhao
A novel targeting theranostic nanoprobe based on single-walled carbon nanotubes (SWCNTs)-natural biopolymer chitosan composites was developed for cancer cell targeting imaging and fluorescence imaging-guided photodynamic therapy. First, chitosan was respectively conjugated with a tumor-homing molecule folic acid, or a photosensitizing drug pyropheophorbide a using a water-soluble carbodiimide coupling chemistry. Chitosan was fluorescently labeled by fluorescein isothiocyanate via the covalently linkage of the isothiocyanate group with the amino group...
November 17, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335242/targeting-and-photodynamic-killing-of-cancer-cell-by-nitrogen-doped-titanium-dioxide-coupled-with-folic-acid
#2
Jin Xie, Xiaobo Pan, Mengyan Wang, Longfang Yao, Xinyue Liang, Jiong Ma, Yiyan Fei, Pei-Nan Wang, Lan Mi
Titanium dioxide (TiO₂) has attracted wide attention as a potential photosensitizer (PS) in photodynamic therapy (PDT). However, bare TiO₂ can only be excited by ultraviolet illumination, and it lacks specific targeting ligands, which largely impede its application. In our study, we produced nitrogen-doped TiO₂ and linked it with an effective cancer cell targeting agent, folic acid (FA), to obtain N-TiO₂-FA nanoconjugates. Characterization of N-TiO₂-FA included Zeta potential, absorption spectra and thermogravimetric analysis...
June 14, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28333878/one-year-results-of-half-versus-standard-dose-photodynamic-therapy-combined-with-ranibizumab-for-polypoidal-choroidal-vasculopathy
#3
Ian Y Wong, Xuan Shi, Rita Gangwani, Lawrence P Iu, Nicholas Fung, Qing Li, Alex L K Ng, Xiaoxin Li
PURPOSE: To explore the efficacy of half-dose verteporfin photodynamic therapy (hd-PDT) and standard-dose photodynamic therapy (sd-PDT), when combined with ranibizumab in the treatment of polypoidal choroidal vasculopathy. METHODS: Subjects were allocated to either the hd-PDT arm or the sd-PDT arm. All subjects received an injection of ranibizumab and PDT treatment (dosage according to allocation) at baseline. Subjects were followed up monthly for 12 months, and re-treatment were given at each visit if criteria were met...
March 22, 2017: Retina
https://www.readbyqxmd.com/read/28333783/dome-shaped-macula-in-myopic-eyes-twelve-month-follow-up
#4
Daniel Lorenzo, Luis Arias, Netan Choudhry, Eduard Millan, Ignacio Flores, Marcos J Rubio, Estefanía Cobos, Pere García-Bru, Alejandro Filloy, Josep M Caminal
PURPOSE: To study the long-term clinical course of dome-shaped macula in myopic eyes and to evaluate treatment efficacy for subretinal fluid (SRF) as a related complication. METHODS: A retrospective, single-center consecutive case series study was conducted. The authors analyzed myopic eyes with dome-shaped macula in patients who presented for evaluation of decreased vision. Dome-shaped macula was defined as a convexity of the retina-choroidal macular complex seen on spectral domain optical coherence tomography images...
April 2017: Retina
https://www.readbyqxmd.com/read/28332669/multiple-imaging-and-excellent-anticancer-efficiency-of-an-upconverting-nanocarrier-mediated-by-single-near-infrared-light
#5
Yan Wang, Guixin Yang, Yanli Wang, Yanping Zhao, Haizhi Jiang, Yuyan Han, Piaoping Yang
It is difficult to meet the requirements of clinical diagnosis through a single imaging technique. Similarly, satisfactory therapy efficacy is also hard to achieve by a single therapeutic modality. It is therefore highly desirable and interesting to simultaneously achieve multimodal imaging and therapies in one single structure. In this study, we developed a core-shell-satellite NaGdF4:Yb,Er,Mn,Co@mSiO2-CuS structure using up-conversion luminescent (UCL) NaGdF4:Yb,Er,Mn,Co as the core, mesoporous silica as the layer, and the photoactive CuS nanoparticles as the satellites...
March 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28330815/antimicrobial-photodynamic-therapy-combined-to-periodontal-treatment-experimental-model
#6
Estéfani L Belinello-Souza, Letícia H Alvarenga, Cintia Lima-Leal, Patrícia Almeida, Carolina Guimarães Leite, Tairine R Lima, Jhosepher Previati-Oliveira, Lucas de Pretto, Anderson Zanardi de Freitas, Adjaci U Fernandes, Rodrigo L Marcos, Renato A Prates
BACKGROUND: Antimicrobial photodynamic therapy (aPDT) has been used as an adjuvant treatment for periodontitis. It combines a photosensitizer with a light source to induce reactive oxygen species and kill microbial cells. PpNetNI is a protoporphyrin derivative, and it has a chemical binding site at biofilm and great affinity to microbial cells. The aim of this study was to investigate the effects of aPDT as an adjuvant treatment for periodontitis. METHODS: Thirty healthy male rats Wistar (Rattus norvegicus) were used in this study (Approved by UNINOVE Ethical committee AN0029/2015)...
March 18, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28330814/ala-pdt-suppressing-the-cell-growth-and-reducing-the-lipogenesis-in-human-sz95-sebocytes-by-mtor-signaling-pathway-in-vitro
#7
Jiang Tuo, Qianqian Wang, Ye Liu, Ying Ma, Li Ma, Jiayi Ying, Chengfeng Zhang, Leihong Xiang
BACKGROUND: 5-Aminolevulinic acid mediated -photodynamic therapy (ALA-PDT) is known to be effective in treating acne vulgaris and other sebaceous gland-related diseases. However, thetherapeutic mechanisms of ALA-PDT still remain undetermined. In this study, we aimed to investigate theeffects and mechanisms of ALA-PDTon the cell growth and lipogenesis of human SZ95 sebocytes. MATERIAL AND METHODS: Human SZ95 sebocytes were treated with different concentration of ALA-PDT...
March 19, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28330805/photodynamic-therapeutic-efficacy-of-symmetrical-diiodinated-squaraine-in-in-vivo-skin-cancer-models
#8
M S Soumya, D Devi Gayathri, K M Shafeekh, Suresh Das, Annie Abraham
BACKGROUND: Photodynamic therapy (PDT) has clinical approval for use as a minimally invasive therapeutic procedure that is able to exert selective cytotoxic activity toward malignant cells. The dye selected for our study, symmetrical diiodinated squaraine, is one of the newly developed photosensitizers. The study is designed to determine the efficacy of PDT mediated by symmetrical diiodinated squaraine in skin tumor induced Swiss albino mice. METHODS: Skin tumor was induced in mice with dimethyl benzanthracene (DMBA) and croton oil...
March 19, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28329611/terap%C3%A3%C2%AAutica-fotodin%C3%A3-mica-com-metil-aminolevulinato-no-tratamento-de-les%C3%A3%C2%B5es-refract%C3%A3-rias-de-micose-fung%C3%A3-ide-resposta-cl%C3%A3-nica-e-histol%C3%A3-gica-mantida-em-dois-doentes
#9
Ana Isabel Teixeira, João Maia E Silva
According to the guidelines proposed by the National Comprehensive Cancer Network, early-stage Mycosis Fungoides (MF) should be treated with skin-directed therapies such as topical steroids or retinoids, topical chemotherapy (carmustin and nitrogen mustard), photochemotherapy, and superficial radiotherapy. Patients with refractory lesions to these therapeutic options are particularly challenging. Photodynamic Therapy (PDT) has been approved to treat cutaneous neoplastic and pre-neoplastic lesions such as superficial basal cell carcinoma, Bowen disease and actinic keratosis...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28327716/chemo-photodynamic-combined-gene-therapy-and-dual-modal-cancer-imaging-achieved-by-ph-responsive-alginate-chitosan-multilayer-modified-magnetic-mesoporous-silica-nanocomposites
#10
Hong Yang, Yin Chen, Zhongyuan Chen, Yue Geng, Xiaoxue Xie, Xue Shen, Tingting Li, Shun Li, Chunhui Wu, Yiyao Liu
Multifunctional theranostics have offered some interesting new opportunities for cancer therapy and diagnosis in the last decade. Herein, magnetic mesoporous silica nanoparticles (M-MSNs) were designed and synthesized, then the photosensitizer chlorin e6 (Ce6) and antitumor drug doxorubicin (Dox) were adsorbed onto the M-MSNs. Biocompatible alginate/chitosan polyelectrolyte multilayers (PEM) were assembled on the M-MSNs to achieve a pH-responsive drug delivery system and adsorb P-gp shRNA for reversing the multidrug resistance...
March 22, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28324723/specific-light-up-pullulan-based-nanoparticles-with-reduction-triggered-emission-and-activatable-photoactivity-for-the-imaging-and-photodynamic-killing-of-cancer-cells
#11
Jing Xia, Liuwei Zhang, Ming Qian, Yongming Bao, Jingyun Wang, Yachen Li
Activatable photosensitizers that can be activated by cancer-associated stimuli have drawn increasing attention for simultaneous fluorescence imaging and photodynamic ablation of cancer cells. Here, we developed a cancer-cell specific photosensitizer nano-delivery system by synthesizing protoporphyrin IX (PpIX)-conjugated pullulan (P) with reducible disulfide bonds. The amphiphilic P-s-s-PpIX conjugate self-assembled in aqueous condition to form core-shell structured nanoparticles (P-s-s-PpIX NPs) with average size of 166nm, showing reduction-controllable stability...
March 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28323591/treatment-and-monitoring-of-central-serous-chorioretinopathy-in-pilots
#12
Ari Shinojima, Ryusaburo Mori, Kyoko Fujita, Mitsuko Yuzawa
BACKGROUND: Central serous chorioretinopathy (CSC), which has the characteristics of a serous retinal detachment (SRD) in the macular area, affects mostly men in the 30- to 50-yr age range. Some patients have persistent SRD, which may cause retinal thinning and photoreceptor impairment. CSC symptoms are gradual vision loss and/or metamorphopsia. Some commercial airline pilots are concerned about CSC symptoms, which can disqualify them from flying for months and can also reoccur. Thus, careful monitoring and treatment of CSC are critical for pilots, especially those with chronic or recurrent CSC...
December 1, 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28322857/vascular-targeted-photodynamic-therapy-with-padeliporfin-for-low-risk-prostate-cancer-treatment-mid-term-oncological-outcomes
#13
Souhil Lebdai, Pierre Bigot, Pierre-Adrien Leroux, Louis-Paul Berthelot, Pierre Maulaz, Abdel-Rahmene Azzouzi
PURPOSE: To assess the mid-term oncological outcomes of vascular-targeted photodynamic therapy with padeliporfin for low-risk prostate cancer treatment. MATERIAL AND METHODS: We prospectively assessed all patients treated with vascular-targeted photodynamic therapy for low-risk prostate cancer in our center. Patients were followed every 6 months. All patients underwent prostate biopsies 6 months post-treatment or in case of biological or clinical progression. Primary endpoint was the progression-free survival...
March 18, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28322024/au-nanoclusters-and-photosensitizer-dual-loaded-spatiotemporal-controllable-liposomal-nanocomposites-enhance-tumor-photodynamic-therapy-effect-by-inhibiting-thioredoxin-reductase
#14
Fuping Gao, Weiping Zheng, Liang Gao, Pengju Cai, Ru Liu, Yaling Wang, Qing Yuan, Yuliang Zhao, Xueyun Gao
Photodynamic therapy (PDT) is a minimally invasive therapeutic procedure of tumors with high selectivity and low side effect. However, it is usually not efficient in long-lasting tumor control. One of the main reasons is tumor cells develop some protective mechanisms that help them to deal with oxidative stress in the environment. The thioredoxin system in cancer is an important antioxidant defense system. Au nanoclusters could effectively inhibit thioredoxin reductase (TrxR) in tumor cell cytoplasm. Herein, Au nanoclusters and photosensitizer Chlorine 6 (Ce6) are co-loaded in spatiotemporal controllable liposomal nanocomposites...
March 21, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28320205/highly-emissive-dye-sensitized-upconversion-nanostructure-for-dual-photosensitizer-photodynamic-therapy-and-bioimaging
#15
Jiating Xu, Piaoping Yang, MIngdi Sun, Huiting Bi, Bin Liu, Dan Yang, Shili Gai, Fei He, Jun Lin
Rare-earth-based upconversion nanotechnology has recently shown great promise for photodynamic therapy (PDT). However, the NIR-induced PDT is greatly restricted by the overheating issues on normal bodies and low yields of reactive oxygen species (ROS, 1O2). Here, IR-808 sensitized upconversion nanoparticles (NaGdF4:Yb,Er@NaGdF4:Nd,Yb) were combined with mesoporous silica, which has Ce6 (red-light-excited photosensitizer) and MC540 (green-light-excited photosensitizer) loaded inside through covalent bond and electrostatic interaction, respectively...
March 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28317584/dealing-with-microscopic-peritoneal-metastases-of-epithelial-ovarian-cancer-a-surgical-challenge
#16
REVIEW
Henri Azaïs, Juan Pablo Estevez, Périne Foucher, Yohan Kerbage, Serge Mordon, Pierre Collinet
Understanding biology and progression mechanisms of peritoneal metastases of epithelial ovarian cancer (EOC) is a cornerstone in the knowledge and the comprehensive management of the disease. Despite clinical remission after the association of complete cytoreductive surgery and platinum-based chemotherapy, peritoneal recurrence still occurs in 60% of patients. Eligible studies, published from 1980 to June 2016, were retrieved through ClinicalTrials.gov, MEDLINE, Cochrane databases and bibliography searches...
March 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28314913/laser-and-light-based-therapy-for-cutaneous-and-soft-tissue-metastases-of-malignant-melanoma-a-systematic-review
#17
REVIEW
Evan Austin, Andrew Mamalis, Derek Ho, Jared Jagdeo
Invasive cutaneous melanoma is a growing health concern. Although surgical excision can effectively treat in situ tumors, use for metastatic melanoma is limited. Laser and light-based therapies may be a valuable palliative treatment option for patients with stage III and stage IV cutaneous metastatic melanoma. Our goal is to review the published literature and provide evidence-based recommendations on laser and light-based palliative therapies for metastatic melanoma. A search of the databases Pubmed, EMBASE, Web of Science, and CINAHL was performed on March 10, 2016...
March 17, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28314866/a-clinical-trial-using-attrition-combined-with-5-aminolevulinic-acids-based-photodynamic-therapy-in-treating-squamous-cell-carcinoma
#18
Jianzhong Peng, Weiguo Feng, Xianyan Luo, Tao Wang, Wenzhong Xiang, Yeqin Dai, Jingyu Zhu, Junhui Zheng
BACKGROUND Squamous cell carcinoma (SCC) is the second most common type of skin cancer, for which non- or mini-invasive treatment is of critical importance. 5-aminolevulinic acids based photodynamic therapy (ALA-PDT) is a mini-invasive approach that causes focal tumor cell injury, apoptosis, and necrosis through light sensitivity. The efficacy of combining ALA-PDT and surgery in treating SCC, however, has not been demonstrated. MATERIAL AND METHODS A total of 60 SCC patients were randomly assigned into attrition plus ALA-PDT group (experimental group) and single ALA-PDT treatment group (control group)...
March 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28314363/raman-and-luminescent-spectra-of-sulfonated-zn-phthalocyanine-enhanced-by-gold-nanoparticles
#19
V Kavelin, O Fesenko, H Dubyna, C Vidal, T A Klar, C Hrelescu, L Dolgov
Sulfonated Zn phthalocyanine, as a prospective photosensitizer in the photodynamic therapy of tumors, is investigated by means of Raman, infrared, and fluorescence spectroscopies. Conventional and surface-enhanced spectra from this photosensitizer are obtained and compared. Gold nano-islands attached to silica cores (Au-SiO2) are proposed as nanostructures providing plasmonically enhanced signals. Pronounced enhancement of Raman and infrared spectral bands from sulfonated Zn phthalocyanine allows their more convenient assignment with vibrational modes of sulfonated Zn phthalocyanine...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28314180/tetra-2-3-pyrazinoporphyrazines-with-externally-appended-pyridine-rings-17-photosensitizing-properties-and-cellular-effects-of-zn-ii-octacationic-and-zn-ii-pt-ii-hexacationic-macrocycles-in-aqueous-media-perspectives-of-multimodal-anticancer-potentialities
#20
Elisa Viola, Maria Pia Donzello, Fabiola Sciscione, Kous Shah, Claudio Ercolani, Giuseppe Trigiante
The photosensitizing activity of two multiply charged porphyrazine derivatives, i.e. the Zn(II) species [(CH3)8LZn](8+) and the Zn(II)/Pt(II) heterobimetallic complex [(PtCl2)(CH3)6LZn](6+) (neutralized byI(-) ions; L=tetrakis-2,3-[5,6-di(2-pyridyl)pyrazino]porphyrazinato dianion) has been examined in the water medium in the presence of SDS under experimental conditions in which the two species are present exclusively in their monomeric form. The determined quantum yield values (ΦΔ) for both complexes, of interest in photodynamic therapy (PDT), are 2...
March 9, 2017: Journal of Photochemistry and Photobiology. B, Biology
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