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https://www.readbyqxmd.com/read/28813052/mixed-ligand-iridium-iii-complexes-as-photodynamic-anticancer-agents
#1
Yue Zheng, Liang He, Dong-Yang Zhang, Cai-Ping Tan, Liang-Nian Ji, Zong-Wan Mao
Many phosphorescent iridium complexes are potent candidates as photodynamic therapeutic agents. In this work, a series of mixed-ligand phosphorescent iridium complexes (Ir1: [Ir(L1)(bpy)Cl](PF6)2; Ir2: [Ir(L1)(ppy)Cl](PF6); Ir3: [Ir(L2)(bpy)Cl](PF6)2; Ir4: [Ir(L2)(ppy)Cl](PF6). L1 = 2,6-bis(2-benzimidazolyl)pyridine; bpy = 2,2'-bipyridine; L2 = 2,6-bis(1-methyl-benzimidazol-2-yl)pyridine; ppy = 2-phenylpyridine) have been synthesized and characterized. These complexes display high luminescence quantum yields and long phosphorescence lifetimes...
August 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28811223/influence-and-mechanism-of-5-aminolevulinic-acid-photodynamic-therapy-on-the-metastasis-of-esophageal-carcinoma
#2
Xiaona Zhang, Longmei Cai, Jingcai He, Xiaoyan Li, Libo Li, Xiaohua Chen, Ping Lan
BACKGROUD: 5-Aminolevulinic acid (ALA) mediated photodynamic therapy (PDT) for the treatment of esophageal cancer was more and more popularly used since it was approved for the treatment of advanced esophageal cancer in 1996. It has been reported to influence the tumor growth and metastasis via a variety of signaling pathways, but its mechanism remains to be further studied. This research studied the effects of ALA-PDT on esophageal carcinoma in vitro and in vivo, discovering its molecular regulating mechanism and the way to enhence the PDT effect...
August 12, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28811165/dicyanomethylene-substituted-benzothiazole-squaraines-the-efficiency-of-photodynamic-therapy-in-vitro-and-in-vivo
#3
Yongbiao Wei, Xiaoxiao Hu, Luyao Shen, Bing Jin, Xiangjun Liu, Weihong Tan, Dihua Shangguan
The lack of ideal photosensitizers limits the clinicalapplication of photodynamic therapy (PDT). Here we report the PDT efficiency of dicyanomethylene substituted benzothiazole squaraine derivatives. This class of squaraine derivatives possess strong absorption and long excitation and emission wavelengths (ex/em, 685/720nm). They show negligible dark toxicity, but can generate singlet oxygen under irradiation resulting in the apoptosis and necrosis of cells (phototoxicity). Changing the side chains of these compounds greatly influences their albumin-binding rate, cellular uptake and their phototoxicity...
August 9, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28809998/temporal-association-of-herpes-zoster-eruption-post-aminolevulinic-acid-hydrochloride-photodynamic-therapy-for-actinic-keratoses
#4
Katie Manno, Joel L Cohen
<p>Herpes zoster is a common and painful disease caused by the reactivation of the varicella-zoster virus with a higher incidence and severity associated with increasing age as well as compromised immune status. Acute inciting events for this eruption are not always known, but can include illness, stress, and mechanical injury. Photodynamic therapy (PDT) is a widely used treatment modality for precancerous skin lesions that has not been previously associated with provoking a herpes zoster outbreak. We present a case of herpes zoster eruption occurring after PDT for actinic keratoses in a patient with Non-Hodgkin Lymphoma (NHL)...
August 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28807774/chlorin-e6-mediated-photodynamic-therapy-promotes-collagen-production-and-suppresses-mmps-expression-via-modulating-ap-1-signaling-in-p-acnes-stimulated-hacat-cells
#5
A-Reum Ryu, Mi-Young Lee
BACKGROUND: Photodynamic therapy (PDT) is a clinically approved therapeutics for cancers and non-neoplastic diseases, based on the use of a photosensitizer activated by a light. The feasibility of PDT depends on several factors, such as PDT dose, photosensitizer efficacy, type of light source, and target tissue irradiated. METHODS: In this study, the second generation photosensitizer chlorin e6 (Ce6) and halogen light were used to investigate their PDT effect on the collagen production and MMPs expression of heat killed P...
August 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28806059/bis-pyrene-doped-cationic-dipeptide-nanoparticles-for-two-photon-activated-photodynamic-therapy
#6
Bingbing Sun, Lei Wang, Qi Li, Ping-Ping He, Huiling Liu, Hao Wang, Yang Yang, Junbai Li
At present, one of main problems for photodynamic therapy (PDT) is how to improve the treatment depth. Two-photon activated (TPA) developed recently provide a possible solution for it. In this work, we report the energy-transferring assembled cationic dipeptide nanoparticles for two-photon activated photodynamic therapy (TPA-PDT). In the nanoparticles, the co-encapsulated two-photon fluorescent dye bis(pyrene) (BP) is an energy donor and a photosensitizer rose bengal (RB) is an acceptor based on an intraparticle fluorescence resonance energy transfer (FRET) mechanism...
August 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28805092/a-review-of-bf-200-ala-for-the-photodynamic-treatment-of-mild-to-moderate-actinic-keratosis
#7
Uwe Reinhold
BF-200 ALA is a combination of a nanoscale-lipid vesicle formulation and the prodrug 5-aminolevulinic acid (5-ALA). The nanoemulsion stabilizes the prodrug and enhances its penetration through the stratum corneum. It has shown excellent therapeutic results in both lesion and field-directed photodynamic therapy of actinic keratosis (AK). AK is an early form of epidermal neoplasia and a precursor of invasive cutaneous squamous cell carcinoma. It is characterized by the combination of visible neoplastic lesions and surrounding tissue also harboring tumorigenic UV-induced mutations: a concept called field cancerization...
August 14, 2017: Future Oncology
https://www.readbyqxmd.com/read/28804945/nanoscale-metal-organic-layers-for-deeply-penetrating-x-ray-induced-photodynamic-therapy
#8
Guangxu Lan, Kaiyuan Ni, Ruoyu Xu, Kuangda Lu, Zekai Lin, Christina Chan, Wenbin Lin
We report the rational design of metal-organic layers (MOLs) that are built from [Hf6O4(OH)4(HCO2)6] secondary building units (SBUs) and Ir[bpy(ppy)2]+- or Ru(bpy)32+-derived tricarboxylate ligands (Hf-BPY-Ir or Hf-BPY-Ru; bpy = 2,2'-bipyridine, ppy = 2-phenyl-pyridine) and their applications in deeply penetrating X-ray induced photodynamic therapy (X-PDT) of colon cancer. Heavy Hf atoms in the SBUs efficiently absorb X-rays and transfer energy to Ir[bpy(ppy)2]+ or Ru(bpy)32+ moieties to induce PDT by generating reactive oxygen species (ROS)...
August 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28802175/conjugate-of-biotin-with-silicon-iv-phthalocyanine-for-tumor-targeting-photodynamic-therapy
#9
Ke Li, Ling Qiu, Qingzhu Liu, Gaochao Lv, Xueyu Zhao, Shanshan Wang, Jianguo Lin
In order to improve the efficacy of photodynamic therapy (PDT), biotin was axially conjugated with silicon(IV) phthalocyanine (SiPc) skeleton to develop a new tumor-targeting photosensitizer SiPc-biotin. The target compound SiPc-biotin showed much higher binding affinity toward BR-positive (biotin receptor overexpressed) HeLa human cervical carcinoma cells than its precursor SiPc-pip. However, when the biotin receptors of HeLa cells were blocked by free biotin, >50% uptake of SiPc-biotin was suppressed, demonstrating that SiPc-biotin could selectively accumulate in BR-positive cancer cells via the BR-mediated internalization...
August 3, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28799232/clinical-outcomes-of-experimental-gingivitis-and-peri-implant-mucositis-treatment-with-professionally-administered-plaque-removal-and-photodynamic-therapy
#10
B Zeza, R Farina, A Pilloni, C Mongardini
AIM: To comparatively evaluate the outcomes of professionally administered plaque removal (PAPR) and photodynamic therapy (PDT) in the treatment for experimentally induced gingivitis (G) and peri-implant mucositis (p-iM). MATERIALS AND METHODS: Twenty systemically healthy patients, each contributing a single implant-supported unit in a posterior sextant and a tooth within the same quadrant, were selected. Patients underwent an experimental G and p-iM trial consisting of a 2-week period of undisturbed plaque accumulation and a 6-week resolution phase following treatment administration...
August 11, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28798899/diagnosed-a-patient-with-central-serous-chorioretinopathy-now-what-management-of-central-serous-chorioretinopathy
#11
Brian E Goldhagen, Raquel Goldhardt
PURPOSE OF REVIEW WHAT IS THE GOAL OF YOUR PAPER? WHAT QUESTIONS DID YOU SEEK TO ANSWER?: The goal of this paper is to provide a comprehensive review of the management options for central serous chorioretinopathy (CSCR). RECENT FINDINGS SUMMARIZE THE LATEST RESEARCH ON YOUR TOPIC: The majority of cases of acute CSCR may be managed with observation and cessation of corticosteroids, if possible, as well as life-style modifications including stress reduction and control of hypertension...
June 2017: Current Ophthalmology Reports
https://www.readbyqxmd.com/read/28797828/gene-expression-profiling-of-fima-gene-encoding-fimbriae-among-clinical-isolates-of-porphyromonas-gingivalis-in-response-to-photo-activated-disinfection-therapy
#12
Maryam Pourhajibagher, Abbas Bahador
BACKGROUND: The endodontic infection therapy majorly aims to eradicate the microbial pathogens. Photo-activated disinfection (PAD), also known as antimicrobial photodynamic therapy, is an alternative antimicrobial modality used to control the microorganisms causing endodontic infections. Notably, microorganisms may be exposed to sub-lethal doses of PAD (sPAD), influencing microbial virulence. The present study assessed the effects of sPAD on expression profiling of the gene associated with the biofilm formation being the most essential virulence factor in Porphyromonas gingivalis strain cells that survive the photodynamic reatment in vivo...
August 7, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28797227/changes-in-macular-sensitivity-after-half-dose-photodynamic-therapy-for-chronic-central-serous-chorioretinopathy
#13
Alp Atik, Yijun Hu, Honghua Yu, Chun Yang, Bin Cai, Yijing Tao, Dongli Li, Yan Chen, Li Lu, Guodong Li, Ling Yuan
BACKGROUND: To evaluate the macular sensitivity changes after half-dose photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSCR). METHODS: Eighteen patients (26 eyes) with chronic CSCR were recruited in the same hospital between April 2011 and December 2012. All patients were treated with one session of half-dose PDT after complete ophthalmic examination. Macular sensitivity examination was performed at baseline and 1, 3 and 6 months post-treatment...
August 10, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28796885/photodynamic-therapy-is-more-effective-than-imiquimod-for-actinic-keratosis-in-organ-transplant-recipients-a-randomized-intra-individual-controlled-trial
#14
K Togsverd-Bo, C Halldin, C Sandberg, H Gonzalez, A M Wennberg, S S Sørensen, H C O Wulf, M Haedersdal
BACKGROUND: Actinic keratoses (AKs) in solid organ transplant recipients (OTRs) are difficult-to-treat pre-malignancies and comparison of topical therapies is therefore warranted. OBJECTIVES: In an intra-individual study to compare efficacy and safety of field treatment with methyl aminolevulinate photodynamic therapy (MAL-PDT) and imiquimod (IMIQ) for AKs in OTRs. MATERIALS AND METHODS: OTRs (n=35) with 572 AKs (grade I-III) in two similar areas in the face, scalp, dorsal hands or forearms were included...
August 10, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28795796/hyper-branched-phosphorescent-conjugated-polymer-dots-with-iridium-iii-complex-as-the-core-for-hypoxia-imaging-and-photodynamic-therapy
#15
Zhiying Feng, Peng Tao, Liang Zou, Pengli Gao, Yuan Liu, Xing Liu, Hua Wang, Shujuan Liu, Qingchen Dong, Jie Li, Bingshe Xu, Wei Huang, Raymond Wai Yeung Wong, Qiang Zhao
Real-time monitoring the contents of molecular oxygen (O2) in tumor cells is of great significance in early diagnosis of cancer. At the same time, the photodynamic therapy (PDT) could be realized by highly toxic singlet oxygen (1O2) generated in situ during the O2 sensing, making it one of the most promising methods for cancer therapy. Herein, the iridium(III) complex cored hyper-branched phosphorescent conjugated polymer dots with the negative charges for hypoxia imaging and highly efficient PDT was rationally designed and synthesized...
August 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28795744/a-cell-selective-glutathione-responsive-tris-phthalocyanine-as-a-smart-photosensitiser-for-targeted-photodynamic-therapy
#16
Sun Y S Chow, Shirui Zhao, Pui-Chi Lo, Dennis K P Ng
A biotin-conjugated disulfide-linked tris(phthalocyanine) has been synthesised and characterised. As shown by electronic absorption and steady-state fluorescence spectroscopy methods, the compound remains non-aggregated in N,N-dimethylformamide, but is significantly aggregated in phosphate buffered saline with 1% Cremophor EL. The reduction in fluorescence intensity and singlet oxygen generation efficiency as compared with the monomeric counterpart suggests that the tris(phthalocyanine) exhibits an excellent self-quenching effect, particularly in an aqueous medium...
August 10, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28793884/therapeutic-comparison-between-treatments-for-vulvar-lichen-sclerosus-study-protocol-of-a-randomized-prospective-and-controlled-trial
#17
Renata A Belotto, Maria Cristina Chavantes, João Paulo Tardivo, Roberto Euzébio Dos Santos, Raquel Civolani Marques Fernandes, Anna Carolina Ratto Tempestini Horliana, Christiane Pavani, Daniela Fátima Teixeira da Silva
BACKGROUND: Vulvar lichen sclerosus (VLS) is a lymphocyte-mediated disease of unknown etiology that can cause intense itching as well stenosis, hindering the evacuation and urination. It can also limit the sex life due to severe local pruritus, pain and dyspareunia (pain during sexual intercourse). The standard treatment for this disease is the use of topical corticosteroids to reduce the clinical symptoms and to try to increase disease-free intervals. Photodynamic therapy (PDT), a treatment that associates a light radiation with a photosensitizing agent and photobiomodulation (PBM) are therapies that can promote effective immunomodulatory responses at the application site by means of photophysical and photochemical phenomena from the molecular to the systemic level, which promote their use in chronic dermatoses...
August 10, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28792860/combination-treatment-with-photodynamic-therapy-and-laser-ablation-in-breast-cancer-an-animal-model-study
#18
Jeeyeon Lee, Ho Yong Park, Wan Wook Kim, Ji Yun Jeong, Yong-Deok Lee, Mi-Hwa Choi, Sehoon Kim, Ji-Young Park, Jin Hyang Jung
PURPOSE: Minimally invasive treatments for early breast cancer have been reported. The objective of this study was to evaluate and compare two such treatments, laser ablation and photodynamic therapy (PDT), regarding their therapeutic efficacy for breast cancer. METHODS: Breast tumors were induced in 12 mice models. The treatment options were classified into four groups: control group (without any treatment, A), group treated only with laser ablation (B), group treated only with PDT (C), and group treated with the combination of laser ablation followed by PDT (D)...
August 8, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28790398/shedding-light-on-alzheimer-s-%C3%AE-amyloidosis-photosensitized-methylene-blue-inhibits-self-assembly-of-%C3%AE-amyloid-peptides-and-disintegrates-their-aggregates
#19
Byung Il Lee, Yoon Seok Suh, You Jung Chung, Kweon Yu, Chan Beum Park
Abnormal aggregation of β-amyloid (Aβ) peptides is a major hallmark of Alzheimer's disease (AD). In spite of numerous attempts to prevent the β-amyloidosis, no effective drugs for treating AD have been developed to date. Among many candidate chemicals, methylene blue (MB) has proved its therapeutic potential for AD in a number of in vitro and in vivo studies; but the result of recent clinical trials performed with MB and its derivative was negative. Here, with the aid of multiple photochemical analyses, we first report that photoexcited MB molecules can block Aβ42 aggregation in vitro...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28790340/verteporfin-inhibits-growth-of-human-glioma-in-vitro-without-light-activation
#20
Ahmad Al-Moujahed, Katarzyna Brodowska, Tomasz P Stryjewski, Nikolaos E Efstathiou, Ioannis Vasilikos, Joanna Cichy, Joan W Miller, Evangelos Gragoudas, Demetrios G Vavvas
Verteporfin (VP), a light-activated drug used in photodynamic therapy for the treatment of choroidal neovascular membranes, has also been shown to be an effective inhibitor of malignant cells. Recently, studies have demonstrated that, even without photo-activation, VP may still inhibit certain tumor cell lines, including ovarian cancer, hepatocarcinoma and retinoblastoma, through the inhibition of the YAP-TEAD complex. In this study, we examined the effects of VP without light activation on human glioma cell lines (LN229 and SNB19)...
August 8, 2017: Scientific Reports
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