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"photodynamic therapy"

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https://www.readbyqxmd.com/read/29791570/osteoradionecrosis-of-the-jaws-case-series-treated-with-adjuvant-low-level-laser-therapy-and-antimicrobial-photodynamic-therapy
#1
Guilherme Henrique Ribeiro, Mariana Comparotto Minamisako, Inês Beatriz da Silva Rath, Aira Maria Bonfim Santos, Alyne Simões, Keila Cristina Rausch Pereira, Liliane Janete Grando
BACKGROUND: Osteoradionecrosis of the jaw (ORNJ) is the most severe and complex sequel of head and neck radiotherapy (RT) because of the bone involved, it may cause pain, paresthesia, foul odor, fistulae with suppuration, need for extra oral communication and pathological fracture. We treated twenty lesions of ORNJ using low-level laser therapy (LLLT) and antimicrobial photodynamic therapy (aPDT). The objective of this study was to stimulate the affected area to homeostasis and to promote the healing of the oral mucosa...
2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29790262/the-efficacy-and-tolerability-of-5-aminolevulinic-acid-5-thermosetting-gel-photodynamic-therapy-pdt-in-the-treatment-of-mild-to-moderate-acne-vulgaris-a-two-center-prospective-assessor-blinded-proof-of-concept-study
#2
Stefano Maria Serini, Maria Vittoria Cannizzaro, Annunziata Dattola, Virginia Garofalo, Esther Del Duca, Alessandra Ventura, Massimo Milani, Elena Campione, Luca Bianchi
BACKGROUND: Acne vulgaris is a chronic inflammatory skin disease, commonly treated with topical or systemic drugs, according to the severity of the condition. Retinoids and antibiotic compounds are considered cornerstone approaches in this condition. However, low adherence to the therapy and the issue of bacterial resistance undermine the efficacy in the long term. Photodynamic therapy (PDT) with 20% aminolevulinic acid (ALA) has shown to be effective in the treatment of inflammatory acne...
May 22, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29789821/a-supramolecular-photosensitizer-system-based-on-the-host-guest-complexation-between-water-soluble-pillar-6-arene-and-methylene-blue-for-durable-photodynamic-therapy
#3
Kui Yang, Jia Wen, Shuang Chao, Jing Liu, Ke Yang, Yuxin Pei, Zhichao Pei
A supramolecular photosensitizer system WP6-MB was synthesized based on water-soluble pillar[6]arene and the photosensitizer methylene blue (MB) via host-guest interaction. MB can complex with WP6 directly with a high complex constant without further modification. In particular, WP6-MB can reduce the dark toxicity of MB remarkably. Furthermore, it can efficiently overcome photobleaching and extend the time for singlet oxygen production of MB upon light irradiation, which is significant for durable photodynamic therapy...
May 23, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29788897/biofilm-destruction-on-endotracheal-tube-associated-pneumonia-by-photodynamic-inactivation
#4
Kate Cristina Blanco, Amanda C Zangirolami, Natalia M Inada, Vanderlei S Bagnato
Hospital infections is a public health problem that can occur with the use of catheters and endotracheal tubes (ETT). Pathogenic microorganisms may adhere to surfaces of these materials forming biofilm. Microbial biofilms presents an extracellular polymer matrix that promotes resistance of microorganisms to factors such as pH, temperature and drugs. The ETT is used to assist a patient with compromised breathing function. ETT biofilm may cause ventilator-associated pneumonia. Pseudomonas aeruginosa and Staphylococcus aureus pneumonia is associated with a 21-fold increase in risk for mechanical ventilation...
May 22, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/29787269/highly-emissive-self-assembled-bodipy-platinum-supramolecular-triangles
#5
Jiong Zhou, Yuzhen Zhang, Guocan Yu, Matthew R Crawley, Cressa Ria Palencia Fulong, Alan Eric Friedman, Sanghamitra Sengupta, Jifu Sun, Qing Li, Feihe Huang, Timothy R Cook
Light-emitting supramolecular coordination complexes (SCCs) have been widely studied for applications in the chemical and biological sciences. Herein, we report the coordination-driven self-assembly of two highly emissive platinum(II) supramolecular triangles (1 and 2) containing BODIPY-based bridging ligands. The metallacycles exhibit favorable anticancer activities against HeLa cells (IC50 of 6.41 μM and 2.11 μM). The characteristic ~570 nm fluorescence of the BODIPY moieties in the metallacycles permits their intracellular visualization using confocal microscopy...
May 22, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29787247/enhanced-photogeneration-of-reactive-oxygen-species-and-targeted-photothermal-therapy-of-c6-glioma-brain-cancer-cells-by-folate-conjugated-gold-photoactive-polymer-nanoparticles
#6
Jaber Keyvan Rad, Ali Reza Mahdavian, Samideh Khoei, Sakine Shirvalilou
Tumor-selective photodynamic therapy is a successful method for ablation of malignant and cancerous cells. Herein, we introduce the design and preparation of functionalized acrylic copolymer nanoparticles with spiropyran (SP) and imidazole groups through a facile semi-continuous emulsion polymerization. Then, Au3+ ions were immobilized and reduced on their surface to obtain photoresponsive gold-decorated polymer nanoparticles (PGPNPs). The prepared PGPNPs were surface-modified with folic acid as a site-specific tumor cell targeting agent and improve intracellular uptake via endocytosis...
May 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29786715/cancer-cell-membrane-coated-magnetic-nanoparticles-for-mr-nir-fluorescence-dual-modal-imaging-and-photodynamic-therapy
#7
Jiong Li, Xuandong Wang, Dongye Zheng, Xinyi Lin, Zuwu Wei, Da Zhang, Zhuanfang Li, Yun Zhang, Ming Wu, Xiaolong Liu
Theranostic nanoprobes integrated with dual-modal imaging and therapeutic functions, such as photodynamic therapy (PDT), have exhibited significant potency in cancer treatments due to their high imaging accuracy and non-invasive advantages for cancer elimination. However, biocompatibility and highly efficient accumulation of these nanoprobes in tumor are still unsatisfactory for clinical application. In this study, a photosensitizer -loaded magnetic nanobead with surface further coated with a layer of cancer cell membrane (SSAP-Ce6@CCM) was designed to improve the biocompatibility and cellular uptake and ultimately achieve enhanced MR/NIR fluorescence imaging and PDT efficacy...
May 22, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29785821/optimizing-photodynamic-therapy-regimens-variables-in-irradiation-may-influence-outcomes
#8
S Ibbotson
No abstract text is available yet for this article.
May 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29785440/an-immunoconjugated-up-conversion-nanocomplex-for-selective-imaging-and-photodynamic-therapy-against-her2-positive-breast-cancer
#9
Gonzalo Ramírez-García, Sandeep S Panikar, Tzarara López-Luke, Valeria Piazza, Miguel Angel Honorato-Colin, Tanya Camacho-Villegas, Rodolfo Hernández-Gutiérrez, Elder De la Rosa
Photodynamic therapy represents a very attractive therapeutic tool considered to be effective, minimally invasive and minimally toxic. However, conventional photodynamic therapy actually has two main constraints: the limited penetration depth of visible light needed for its activation, and the lack of selectivity. Considering this, this work reports the synthesis and evaluation of a novel nanoconjugate for imaging and selective photodynamic therapy against HER2-positive breast cancer, a particularly aggressive form of the disease...
May 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29785290/endobronchial-treatment-of-peripheral-tumors-ongoing-development-and-perspectives
#10
Thibault Vieira, Jean-Baptiste Stern, Philippe Girard, Raffaelle Caliandro
The expanded possibilities to explore the lung deeper with new tools such as electromagnetic navigation bronchoscopy (ENB) or radial probe endobronchial ultrasonography (radial EBUS), combined with miniaturization of traditional local therapies such as radiofrequency ablation (RFA), radiotherapy, cryotherapy or photodynamic therapy, let the bronchoscopists hope for new ways of endoscopic treatments. This challenge could change the practice in the upcoming decades but raise some physical and technical issues...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29785107/near-infrared-light-mediated-photodynamic-photothermal-therapy-nanoplatform-by-the-assembly-of-fe-3-o-4-carbon-dots-with-graphitic-black-phosphorus-quantum-dots
#11
Ming Zhang, Wentao Wang, Yingjun Cui, Ninglin Zhou, Jian Shen
Background: Recently, combined photodynamic therapy (PDT) and photothermal therapy (PTT) has become a desired treatment for cancer. However, the development of economic, high-efficiency, and safe photosensitizers/photothermal agents remains a significant challenge. Methods: A novel nanocomposite has been developed via the assembly of iron oxide carbon dot (Fe3 O4 -CDs) nanoparticles and black phosphorus quantum dots (genipin [GP]-polyglutamic acid [PGA]-Fe3 O4 -CDs@BPQDs), and this nanocomposite shows a broad light-absorption band and a photodegradable character...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29783745/loading-of-indocyanine-green-within-polydopamine-coated-laponite-nanodisks-for-targeted-cancer-photothermal-and-photodynamic-therapy
#12
Fanli Xu, Mengxue Liu, Xin Li, Zhijuan Xiong, Xueyan Cao, Xiangyang Shi, Rui Guo
The combination of photothermal therapy (PTT) and photodynamic therapy (PDT) in cancer treatment has attracted much attention in recent years. However, developing highly efficient and targeted therapeutic nanoagents for amplifying PTT and PDT treatments remains challenging. In this work, we developed a novel photothermal and photodynamic therapeutic nanoplatform for treatment of cancer cells overexpressing integrin αv β₃ through the coating of polydopamine (PDA) on indocyanine green (ICG)-loaded laponite (LAP) and then further conjugating polyethylene glycol-arginine-glycine-aspartic acid (PEG-RGD) as targeted agents on the surface...
May 19, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29783654/recent-progress-in-upconversion-photodynamic-therapy
#13
REVIEW
Hailong Qiu, Meiling Tan, Tymish Y Ohulchanskyy, Jonathan F Lovell, Guanying Chen
Photodynamic therapy (PDT) is a minimally invasive cancer modality that combines a photosensitizer (PS), light, and oxygen. Introduction of new nanotechnologies holds potential to improve PDT performance. Upconversion nanoparticles (UCNPs) offer potentially advantageous benefits for PDT, attributed to their distinct photon upconverting feature. The ability to convert near-infrared (NIR) light into visible or even ultraviolet light via UCNPs allows for the activation of nearby PS agents to produce singlet oxygen, as most PS agents absorb visible and ultraviolet light...
May 18, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29782309/in-memoriam-assistant-professor-kre%C3%A5-imir-kostovi%C3%A4-md-phd-16-october-1969-15-october-2017
#14
Branka Marinović
On a Sunday afternoon almost six months ago, we were deeply moved by the news that our Krešimir is no longer with us. The sad news spread from Sarajevo with the speed only most horrible and saddest news can achieve. And everybody who was reached by these news wondered whether it was possible and whether it was true. Because our professor Kostović left us a day before his 48th birthday. Krešimir Kostović was born on the 16th October 1969 in Zagreb, where he completed primary and secondary education. He enrolled at the University of Zagreb School of Medicine in 1988, and got his medical degree in 1995...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29781276/light-induced-hypoxia-triggered-living-nanocarriers-for-synergistic-cancer-therapy
#15
Wenliang Wang, Lin Lin, Xiaojing Ma, Bo Wang, Sanrong Liu, Xinxin Yan, Shengran Li, Huayu Tian, Xifei Yu
Living drug delivery system has been proposed as new concept materials since it is able to communicate with biological system, sense subtle changes of body microenvironment caused by disease and then make rapid response to cure in early stage of disease. Herein, taking full advantage of the tumor hypoxia physiology and successive effects of photodynamic therapy (PDT), we designed a new living delivery system via combining the PDT and hypoxia-responsive chemotherapy, abbreviated as Ce6-PEG-Azo-PCL. Then, according to the facts that oxygen can be converted into reactive oxygen species during irradiation of the photosensitizer, tumor cells could be killed after the poly(ethylene glycol) (PEG) conjugated photosensitizer chlorine e6 were irradiated at tumor site...
May 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29781025/an-ultrathin-photosensitizer-for-simultaneous-fluorescence-imaging-and-photodynamic-therapy
#16
Tongyang Hu, Jun He, Shaomin Zhang, Xuan Mei, Weiku Zhang, Ruizheng Liang, Min Wei, David G Evans, Xue Duan
An ultrathin photosensitizer was prepared by immobilization of chlorin e6 (Ce6) and carbon dots (CDs) onto layered double hydroxide (LDH) nanosheets, which exhibited excellent fluorescence imaging and photodynamic therapy performance toward cancer theranostics.
May 21, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29780488/a-pre-protective-strategy-for-precise-tumor-targeting-and-efficient-photodynamic-therapy-with-a-switchable-dna-upconversion-nanocomposite
#17
Zhengze Yu, Yegang Ge, Qiaoqiao Sun, Wei Pan, Xiuyan Wan, Na Li, Bo Tang
Tumor-specific targeting based on folic acid (FA) is one of the most common and significant approaches in cancer therapy. However, the expression of folate receptors (FRs) in normal tissues will lead to unexpected targeting and unsatisfactory therapeutic effect. To address this issue, we develop a pre-protective strategy for precise tumor targeting and efficient photodynamic therapy (PDT) using a switchable DNA/upconversion nanocomposite, which can be triggered in the acidic tumor microenvironment. The DNA/upconversion nanocomposite is composed of polyacrylic acid (PAA) coated upconversion nanoparticles (UCNPs), the surface of which is modified using FA and chlorin e6 (Ce6) functionalized DNA sequences with different lengths...
April 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780196/light-fluence-dosimetry-in-lung-simulating-cavities
#18
Timothy C Zhu, Michele M Kim, Jonah Padawer, Andreea Dimofte, Mary Potasek, Karl Beeson, Evgueni Parilov
Accurate light dosimery is critical to ensure consistent outcome for pleural photodynamic therapy (pPDT). Ellipsoid shaped cavities with different sizes surrounded by turbid medium are used to simulate the intracavity lung geometry. An isotropic light source is introduced and surrounded by turbid media. Direct measurements of light fluence rate were compared to Monte Carlo simulated values on the surface of the cavities for various optical properties. The primary component of the light was determined by measurements performed in air in the same geometry...
January 2018: Proceedings of SPIE
https://www.readbyqxmd.com/read/29779986/photodynamic-therapy-corrects-abnormal-cancer-associated-gene-expression-observed-in-actinic-keratosis-lesions-and-induces-a-remodeling-effect-in-photodamaged-skin
#19
Florence Joly, Sophie Deret, Bastien Gamboa, Corinne Menigot, Paul Fogel, Carine Mounier, Pascale Reiniche, Farzaneh Sidou, Jérome Aubert, John Lear, Anthony A Fryer, Francesca Zolezzi, Johannes J Voegel
BACKGROUND: Actinic keratoses (AK) are proliferations of neoplastic keratinocytes in the epidermis resulting from cumulative exposure to ultraviolet radiation (UVR), which are liable to transform into squamous cell carcinoma (SCC). Organ Transplant Recipients (OTR) have an increased risk of developing SCC as a consequence of long-term immunosuppressive therapy. The aim of this study was to determine the molecular signature of AKs from OTR prior to treatment with methyl aminolevulinate-photodynamic therapy (MAL-PDT), and to assess what impact the treatment has on promoting remodeling of the photo-damaged skin...
May 17, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29778525/mucus-penetrating-nanoparticles-promising-drug-delivery-systems-for-the-photodynamic-therapy-of-intestinal-cancer
#20
Juliane Anderski, Laura Mahlert, Dennis Mulac, Klaus Langer
Photodynamic therapy (PDT) is an auspicious therapy approach for the treatment of cancer. Despite its numerous benefits, the drug delivery of the used photosensitizer (PS) to target locations inside the human body remains a main therapy challenge, since the standard intravenous PS injection often causes systemic side-effects. To circumvent this therapy drawback, the oral application represents a promising administration alternative. Especially for the treatment of intestinal cancer it offers the possibility of a local treatment with a reduced likelihood for adverse drug reactions...
May 17, 2018: European Journal of Pharmaceutics and Biopharmaceutics
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