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https://www.readbyqxmd.com/read/28103628/treatment-of-a-vulvar-paget-s-disease-by-photodynamic-therapy-with-a-new-light-emitting-fabric-based-device
#1
Claire Vicentini, Olivier Carpentier, Fabienne Lecomte, Elise Thecua, Laurent Mortier, Serge R Mordon
INTRODUCTION: The non-invasive vulvar Paget's disease is an intra-epidermal carcinoma with glandular characteristics. It appears like an erythematous plaque. The main symptoms are pruritus and pain. The standard treatment is surgical excision in depth. This treatment is complicated with a severe morbidity and photodynamic therapy can be an alternative choice. However, the pain experienced during the photodynamic treatment of vulvar lesion is intense and leads to a premature interruption of the treatment...
January 19, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28101541/inner-salt-shaped-small-molecular-photosensitizer-with-extremely-enhanced-two-photon-absorption-for-mitochondrial-targeted-photodynamic-therapy
#2
Wenbo Hu, Tingchao He, Rongcui Jiang, Jun Yin, Lin Li, Xiaomei Lu, Hui Zhao, Lei Zhang, Ling Huang, Handong Sun, Wei Huang, Quli Fan
Herein, we experimentally and theoretically demonstrate an unprecedentedly enhanced two-photon absorption in a small organic molecule by a simple introduction of an inner salt-shaped structure. Moreover, such an inner salt-shaped small molecule also exhibits superior singlet oxygen quantum yield and fascinating structure-inherent mitochondrial-targeting ability for highly efficient two-photon photodynamic therapy via a mitochondrial apoptosis pathway.
January 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28099873/antimicrobial-photodynamic-therapy-as-an-adjunct-for-treatment-of-deep-carious-lesions-a-systematic-review
#3
REVIEW
Fabian Cieplik, Wolfgang Buchalla, Elmar Hellwig, Ali Al-Ahmad, Karl-Anton Hiller, Tim Maisch, Lamprini Karygianni
For deep carious lesions, a more conservative treatment modality ("selective caries removal") has been proposed, where only the heavily contaminated dentine is removed. In this regard, effective adjuncts for cavity disinfection such as the antimicrobial photodynamic therapy (aPDT) can be valuable clinically prior to definitive restoration. Therefore, the aim of this study was to systematically assess clinical studies on the effectiveness of aPDT as a supplementary tool in the treatment of deep caries lesions...
January 15, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28098886/novel-zinc-phthalocyanine-as-a-promising-photosensitizer-for-photodynamic-treatment-of-esophageal-cancer
#4
Weronika Kuzyniak, Jacob Schmidt, Wojciech Glac, Janine Berkholz, Gustav Steinemann, Björn Hoffmann, Eugeny A Ermilov, Ayşe Gül Gürek, Vefa Ahsen, Bianca Nitzsche, Michael Höpfner
Photodynamic therapy (PDT) has gathered much attention in the field of cancer treatment and is increasingly used as an alternative solution for esophageal cancer therapy. However, there is a constant need for improving the effectiveness and tolerability of the applied photosensitizers (PS). Here, we propose tetra-triethyleneoxysulfonyl substituted zinc phthalocyanine (ZnPc) as a promising PS for photodynamic treatment of esophageal cancer. ZnPc-induced phototoxicity was studied in two human esophageal cancer cell lines: OE-33 (adenocarcinoma) and Kyse-140 (squamous cell carcinoma)...
January 17, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28098777/new-irradiation-method-with-indocyanine-green-loaded-nanospheres-for-inactivating-periodontal-pathogens
#5
Yasuyuki Sasaki, Jun-Ichiro Hayashi, Takeki Fujimura, Yuki Iwamura, Genta Yamamoto, Eisaku Nishida, Tasuku Ohno, Kosuke Okada, Hiromitsu Yamamoto, Takeshi Kikuchi, Akio Mitani, Mitsuo Fukuda
Antimicrobial photodynamic therapy (aPDT) has been proposed as an adjunctive strategy for periodontitis treatments. However, use of aPDT for periodontal treatment is complicated by the difficulty in accessing morphologically complex lesions such as furcation involvement, which the irradiation beam (which is targeted parallel to the tooth axis into the periodontal pocket) cannot access directly. The aim of this study was to validate a modified aPDT method that photosensitizes indocyanine green-loaded nanospheres through the gingivae from outside the pocket using a diode laser...
January 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28097863/mitochondria-targeted-protein-ruthenium-photosensitizer-for-efficient-photodynamic-applications
#6
Sabyasachi Chakrabortty, Bikram Keshari Agrawalla, Anne Stumper, Naidu M Vegi, Stephan Fischer, Christian Reichardt, Michael Kögler, Benjamin Dietzek, Michaela Feuring-Buske, Christian Buske, Sven Rau, Tanja Weil
Organelle-targeted photosensitization represents a promising approach in photodynamic therapy where the design of the active photosensitizer (PS) is very crucial. In this work, we developed a macromolecular PS with multiple copies of mitochondria-targeting groups and ruthenium complexes that displays highest phototoxicity towards several cancerous cell lines. In particu-lar, enhanced anti-cancer activity was demonstrated in acute myeloid leukemia cell lines, where significant impairment of proliferation and clonogenicity occurs...
January 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28095557/the-photodynamic-therapy-experience-of-a-high-volume-laser-and-dermatologic-surgery-center
#7
David E Orbuch, Lauren Penn, Bradley S Bloom, Jeremy A Brauer, Daniel B Shin, Joshua Greenbaum, Leonard J Bernstein, Elliot T Weiss, Robert T Anolik, Roy G Geronemus
BACKGROUND: Photodynamic therapy (PDT) is an FDA approved treatment for actinic keratoses (AK's) although multiple off-label indi- cations are reported. Despite frequent use for AK's, no clear consensus exists regarding protocols for overall treatment parameters. METHODS: Retrospective chart review of 1,491 subjects who underwent PDT between 2007 and 2011 at a high volume laser surgery center. Demographic information, clinical history, treatment data, and subsequent diagnosis of skin cancers were recorded...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095542/the-two-faces-of-fractionated-photodynamic-therapy-increasing-efficacy-with-light-fractionation-or-adjuvant-use-of-fractional-laser-technology
#8
Margit L W Juhasz, Melissa K Levin, Ellen S Marmur
"Fractionated photodynamic therapy (PDT)" is a new term being used by dermatologists to describe advances in PDT technology including fractionated light or the adjuvant use of fractional lasers. Although dermatologists have used PDT since the early 1990s for the treatment of photodamage and precancerous lesions, newer developments in technology have allowed for the treatment of non-melanoma skin cancers (NMSCs), in ammatory disorders, and even uses in the eld of anti-aging. Recent developments in fractionated light therapy have allowed for PDT with dark intervals and two-fold illumination schemes to increase cellular damage and apoptosis...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095373/comparison-of-lesion-by-lesion-and-field-photodynamic-therapy-in-the-prevention-of-actinic-keratoses-a-randomized-split-face-single-blind-pilot-study
#9
Inge Seubring, Joannes M M Groenewoud, Marie-Jeanne P Gerritsen
BACKGROUND: Actinic keratoses (AKs) are often treated separately, lesion by lesion. However, in the past years, AKs have been described as a field disease and not limited to single clinically apparent lesions. Treatment should therefore target an area of field change which may reduce the risk of development of further AKs, second tumours, and local recurrence. OBJECTIVE: The primary objective was to determine the number of new lesions at 9 months after methyl aminolevulinate photodynamic therapy (MAL-PDT)...
January 18, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28093604/pretreatment-with-5-fluorouracil-cream-enhances-the-efficacy-of-daylight-mediated-photodynamic-therapy-for-actinic-keratosis
#10
Christoffer V Nissen, Ida Marie Heerfordt, Stine R Wiegell, Carsten S Mikkelsen, Hans C Wulf
The efficacy of photodynamic therapy (PDT) with methyl aminolevulinate is reduced when treating actinic keratosis (AK) on the extremities in comparison with the face and scalp. Studies indicate that PDT efficacy can be improved by combining PDT with other treatment modalities. This randomized intra-individual study investigated whether pretreatment with topical 5% 5-fluorouracil (5-FU) enhanced the treatment efficacy of daylight-mediated PDT in 24 patients with AKs on the hands. One hand of each patient was given 7 days of pretreatment with 5-FU twice daily before daylight-PDT, whereas the other hand was treated with daylight-PDT alone...
January 17, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28093601/ambulatory-photodynamic-therapy-for-superficial-basal-cell-carcinoma-an-effective-light-source
#11
Janneke P H M Kessels, Nedim Dzino, Patty J Nelemans, Klara Mosterd, Nicole W J Kelleners-Smeets
is missing (Short communication).
January 17, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28092483/photodynamic-inactivation-of-cariogenic-pathogens-using-curcumin-as-photosensitizer
#12
Natália Costa Araújo, Rebeca Ferraz de Menezes, Vanda Sanderana Macêdo Carneiro, Alexandrino Pereira Dos Santos-Neto, Carla Raquel Fontana, Vanderlei Salvador Bagnato, Catherine Malinda Harvey, Marleny Elizabeth Martinez Gerbi
OBJECTIVE: This investigation assessed the susceptibility of Streptococcus mutans and Lactobacillus acidophilus to Photodynamic Therapy (PDT) when grown simultaneously in dentine carious lesions. BACKGROUND DATA: PDT is a technique that utilizes light to activate photosensitizers in the presence of oxygen to produce reactive radicals. MATERIALS AND METHODS: A culture medium of 1% glucose, 2% sucrose, 1% young primary culture of L. acidophilus 10(8) CFU/mL, and S...
January 12, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28091953/fullerene-c60-penetration-into-leukemic-cells-and-its-photoinduced-cytotoxic-effects
#13
D Franskevych, K Palyvoda, D Petukhov, S Prylutska, I Grynyuk, C Schuetze, L Drobot, O Matyshevska, U Ritter
Fullerene C60 as a representative of carbon nanocompounds is suggested to be promising agent for application in photodynamic therapy due to its unique physicochemical properties. The goal of this study was to estimate the accumulation of fullerene C60 in leukemic cells and to investigate its phototoxic effect on parental and resistant to cisplatin leukemic cells. Stable homogeneous water colloid solution of pristine C60 with average 50-nm diameter of nanoparticles was used in experiments. Fluorescent labeled C60 was synthesized by covalent conjugation of C60 with rhodamine B isothiocyanate...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28091850/repeated-applications-of-photodynamic-therapy-on-candida-glabrata-biofilms-formed-in-acrylic-resin-polymerized
#14
Lírian Silva de Figueiredo Freitas, Rodnei Dennis Rossoni, Antonio Olavo Cardoso Jorge, Juliana Campos Junqueira
Previous studies have been suggested that photodynamic therapy (PDT) can be used as an adjuvant treatment for denture stomatitis. In this study, we evaluated the effects of multiple sessions of PDT on Candida glabrata biofilms in specimens of polymerized acrylic resin formed after 5 days. Subsequently, four applications of PDT were performed on biofilms in 24-h intervals (days 6-9). Also, we evaluated two types of PDT, including application of laser and methylene blue or light-emitting diode (LED) and erythrosine...
January 14, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28090694/graphene-oxide-wrapped-sio2-tio2-hollow-nanoparticles-loaded-with-photosensitizer-for-photothermal-and-photodynamic-combination-therapy
#15
Yoonsun Jang, Sojin Kim, Seungae Lee, Chang-Min Yoon, Inkyu Lee, Jyongsik Jang
Graphene oxide (GO) enwrapped SiO2/TiO2 hollow nanoparticles (GO-HNP) are synthesized by stöbber method and used as a nanocarrier for loading protoporphyrin IX (PpIX). The synthesized nanoparticle has high dispersibitliy and high uniformity in diameter (ca. 50 nm). . Furthermore, this nanoparticle shows 808 nm laser induced PpIX release property (photo-induced "on-off" drug release system). The GO-HNP-PpIX is employed for inducing both photothermal therapy (PTT) and photodynamic therapy (PDT). The synergic effect of the PTT and PDT exhibits powerful anti-cancer property...
January 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28089923/nursing-care-management-of-photodynamic-therapy-in-digestive-tract-carcinomas-at-a-single-cancer-center
#16
Atsushi Nanashima, Koji Nakashima, Hiroshi Kawakami, Shinya Ashizuka, Yoshimasa Kubota
The primary goal of nursing care in cases of endoscopic photodynamic therapy (PDT) for digestive tract carcinoma is to prevent phototoxicity by the intravenous administration of photosensitizers. The adequate protocol and management of patients should be conducted under the instruction of expert physicians. Our experiences of administering porfimer sodium and talaporfin sodium during clinical PDT provide insight regarding the specific management protocol of each photosensitizer during an in-hospital stay. We herein report our nursing protocol based on 15 years of experience...
January 9, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28089003/treatment-of-myxoid-cysts-with-intralesional-photodynamic-therapy-a-case-series
#17
María Jesús Suárez Valladares, Manuel Ángel Rodríguez Prieto
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28088439/antimicrobial-activity-of-photodynamic-therapy-in-combination-with-colistin-against-a-pan-drug-resistant-acinetobacter-baumannii-isolated-from-burn-patient
#18
Ebrahim Boluki, Hossein Kazemian, Hadi Peeridogaheh, Mohammad Yousef Alikhani, Sima Shahabi, Leili Beytollahi, Roghayeh Ghorbanzadeh
Nosocomially-acquired multi-, extensively-, and pandrug resistant (MDR, XDR, and PDR) strains of microorganisms such as Acinetobacter baumannii remain a serious cause of infection and septic mortality in burn patients. Treatment of patients with nosocomial burn wound infections is often complicated by drug-resistant strains of A. baumannii. Today, many researchers are focusing on the investigation of novel non-antibiotic strategies such as photodynamic therapy (PDT). We report a new PDT strategy that suppresses colistin resistance in PDR A...
January 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28088105/tectona-grandis-leaf-extract-free-and-associated-with-nanoemulsions-as-a-possible-photosensitizer-of-mouse-melanoma-b16-cell
#19
Cydia de Menezes Furtado, Fernando Sergio Escocio Drumond Viana de Faria, Ricardo Bentes Azevedo, Karen Py-Daniel, Ana Lygia Dos Santos Camara, Jaqueline Rodriguez da Silva, Everton de Holanda Oliveira, Anselmo Fortunato Ruiz Rodriguez, Igor Anatolievich Degterev
Over the past six years we have been studying extracts from tropical, specially Amazon, plants, to search for new sensitizers for photodynamic therapy of cancer and infectious diseases. Tectona grandis is a genus of tropical hardwood trees in the mint family, Lamiaceae. That is native to south and southeast Asia, but since the end of the 20th century is also gaining ground in the Amazon. The present work aims to evaluate the photodynamic potential of hydro-alcoholic extract from Tectona grandis LF leaves (TGE) and the same extract prepared as the oil-water nanoemulsion (TGE-NE) against melanoma B16 F10 cells...
January 5, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28087479/synthesis-and-characterization-of-gold-nanostructured-chorin-e6-for-photodynamic-therapy
#20
L Vieira, M L Castilho, I Ferreira, J Ferreira-Strixino, K C Hewitt, L Raniero
Photodynamic therapy is an alternative treatment for cancer based on cellular uptake of a photosensitizer, illuminated with an appropriate wavelength in the presence of oxygen. A cascade of reactions generates reactive oxygen species leading to cell death. Using carbodiimide chemistry, chlorin e6 (Ce6) was covalently bonded to thiourea, and (via the sulphur end group) to gold nanoparticles (AuNPs), forming the Ce6-AuNP complex. Ce6 absorbs in the range 650-680nm, where the coefficient of biological tissue absorption is low (part of the therapeutic window), which is ideal for biological application...
January 10, 2017: Photodiagnosis and Photodynamic Therapy
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