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https://www.readbyqxmd.com/read/28918177/photodynamic-therapy-in-oral-potentially-malignant-disorders-critical-literature-review-of-existing-protocols
#1
REVIEW
Jéssica Araújo Figueira, Vanessa Cristina Veltrini
INTRODUCTION: Oral cancer is a serious public health issue. Apart from its high rate of prevalence, incidence and mortality, it can often result in more complex and expensive treatment when diagnosed late. Potentially malignant disorders (PMDs) can precede oral cancer, and are usually treated by surgical excision. However, in many cases patients are elderly and multiple interventions may be required. Photodynamic therapy (PDT) is a simple alternative, which has been successfully used in the treatment of oral PMDs...
September 13, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28916656/chemotherapy-induced-macrophage-infiltration-into-tumors-enhances-nanographene-based-photodynamic-therapy
#2
Yang Zhao, Chenran Zhang, Liquan Gao, Xinhe Yu, Jianhao Lai, Dehua Lu, Rui Bao, Yanpu Wang, Bing Jia, Fan Wang, Zhaofei Liu
Increased recruitment of tumor-associated macrophages (TAM) to tumors following chemotherapy promotes tumor resistance and recurrence and correlates with poor prognosis. TAM depletion suppresses tumor growth, but is not highly effective due to the effects of tumorigenic mediators from other stromal sources. Here we report that adoptive macrophage transfer led to a dramatically enhanced photodynamic therapy (PDT) effect of 2-(1-hexyloxyethyl)-2-devinyl pyropheophor-bide-alpha (HPPH)-coated polyethylene glycosylated nanographene oxide [GO(HPPH)-PEG] by increasing its tumor accumulation...
September 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28916141/in-vivo-multimodal-tumor-imaging-and-photodynamic-therapy-with-novel-theranostic-agents-based-on-the-porphyrazine-framework-chelated-gadolinium-iii-cation
#3
Diana V Yuzhakova, Svetlana A Lermontova, Ilya S Grigoryev, Maria S Muravieva, Alena I Gavrina, Marina V Shirmanova, Irina V Balalaeva, Larisa G Klapshina, Elena V Zagaynova
BACKGROUND: A promising strategy for cancer diagnosis and therapy is the development of an agent for multimodal imaging and treatment. In the present paper we report on two novel multifunctional agents prepared on the porphyrazine pigment platform using a gadolinium (III) cation chelated by red-fluorescent tetrapyrrole macrocycles (GdPz1 and GdPz2). METHODS: Spectral and magnetic properties of the compounds were analyzed. Monitoring of GdPz1 and GdPz2 accumulation in the murine colon carcinoma CT26 was performed in vivo using fluorescence imaging and MRI...
September 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28915492/enhancement-of-5-aminolevulinic-acid-phototoxicity-by-encapsulation-in-polysaccharides-based-nanocomplexes-for-photodynamic-therapy-application
#4
Antonio Di Martino, Alena Pavelkova, Pavel S Postnikov, Vladimir Sedlarik
Polysaccharides based nanocomplexes have been developed for encapsulation, controlled delivery and to enhance the phototoxicity of the photosensitizer 5-aminolevulinic acid for application in photodynamic therapy. The nanocomplexes were prepared by coacervation in a solvent free environment using chitosan as polycation while alginic and polygalacturonic acid as polyanions. The complexes showed average dimension in the range 90-120nm, good stability in simulated physiological media and high drug encapsulation efficiency, up to 800μg per mg of carrier...
August 8, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28915410/aiegens-for-biological-process-monitoring-and-disease-theranostics
#5
REVIEW
Xinggui Gu, Ryan T K Kwok, Jacky W Y Lam, Ben Zhong Tang
Biological processes are of great significance for the normal physiological functions of living organisms and closely related to the health. Monitoring of biological processes and diagnosis of diseases based on fluorescent techniques would provide comprehensive insight into mechanism of life and pathogenesis of diseases, precisely guiding therapeutic effect in theranostics. It largely relied on fluorophores with the properties of excellent photostability, large Stokes shift, high signal-to-noise ratio and free of aggregation-caused quenching (ACQ) effect...
September 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/28914323/the-spectroscopic-impact-of-interactions-with-the-four-gouterman-orbitals-from-peripheral-decoration-of-porphyrins-with-simple-electron-withdrawing-and-donating-groups
#6
Angel Zhang, Lydia Kwan, Martin J Stillman
Tetrapyrroles are of great interest for solar cell and photodynamic therapy applications due to their structural analogy with chlorophyll, a natural photosensitizer. Unsubstituted symmetric porphyrins exhibit weak absorption in the red region which makes them unsuitable for these applications. The push-pull peripheral decoration modifies the energies of the frontier molecular orbitals, which in turn influences the tetrapyrrole's spectroscopic properties. The absorption, magnetic circular dichroism, and emission spectra were measured for four zinc tetratolylporphyrin compounds substituted peripherally with a fused dimethoxybenzo group as an electron withdrawing group (EWG) on one pyrrole and on the opposite pyrrole, a single acetamido (1), a nitro (2), a proton (3), or a benzoylamino (4) substituent...
September 15, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28914009/luminescent-diagnostics-of-skin-defects-in-the-near-infrared-range
#7
Yuriy V Alekseev, Valentina D Rumyantseva, Anastasiya S Gorshkova, Anastasiya E Shchelkunova, Igor P Shilov, Andrey V Ivanov
Photodynamic therapy becomes a widely spread method due to cancer growth in the world. However, to detect tumors at early stages, it is necessary to carry out diagnostic measures in a timely manner. Our aim was to test the developed pharmaceutical composition, which can be used for external application in early fluorescent diagnostics even in the absence of visual changes, as well as for therapy effectiveness control. Pharmacokinetic studies on laboratory animals and volunteers were carried out. The results have shown that the dipotassium salt of Yb3+-dimethoxyhematoporphyrin IX, which is highly soluble in water and stable in storage, is a promising marker for earlier diagnostics of tumors and can be used in dermatology, dentistry, gynecology, cosmetology, ear, nose, and throat diseases, veterinary, and in other areas of medicine...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28913666/quantitative-modeling-of-the-dynamics-and-intracellular-trafficking-of-far-red-light-activatable-prodrugs-implications-in-stimuli-responsive-drug-delivery-system
#8
Mengjie Li, Pritam Thapa, Pallavi Rajaputra, Moses Bio, Cody J Peer, William D Figg, Youngjae You, Sukyung Woo
The combination of photodynamic therapy (PDT) with anti-tumor agents is a complimentary strategy to treat local cancers. We developed a unique photosensitizer (PS)-conjugated paclitaxel (PTX) prodrug in which a PS is excited by near-infrared wavelength light to site-specifically release PTX while generating singlet oxygen (SO) to effectively kill cancer cells with both PTX and SO. The aim of the present study was to identify the determinants influencing the combined efficacy of this light-activatable prodrug, especially the bystander killing effects from released PTX...
September 14, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/28912944/photodynamic-therapy-with-bengal-rose-and-derivatives-against-leishmania-amazonensis
#9
Taisa Rocha Navasconi, Vanessa Nesi Dos Reis, Camila Fabiano Freitas, Paulo Cesar de Souza Pereira, Wilker Caetano, Noboru Hioka, Maria Valdrinez Campana Lonardoni, Sandra Mara Alessi Aristides, Thaís Gomes Verzignassi Silveira
Introduction: The treatment of cutaneous leishmaniasis (CL) is based primarily on the use of pentavalent antimonials, which may lead to many side effects limiting their use. Photodynamic therapy (PDT) is an alternative for the treatment of CL, and some xanthene dyes have the potential for use in PDT. Methods: The xanthenes rose bengal B (RB) and its derivatives rose bengal methyl ester (RBMET), and butyl ester (RBBUT) were analyzed for leishmanicidal activity against promastigotes and intracellular amastigotes of Leishmania amazonensis...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/28911109/selective-tumor-cell-death-induced-by-irradiated-riboflavin-through-recognizing-dna-g-t-mismatch
#10
Yi Yuan, Yongyun Zhao, Lianqi Chen, Jiasi Wu, Gangyi Chen, Sheng Li, Jiawei Zou, Rong Chen, Jian Wang, Fan Jiang, Zhuo Tang
Riboflavin (vitamin B2) has been thought to be a promising antitumoral agent in photodynamic therapy, though the further application of the method was limited by the unclear molecular mechanism. Our work reveals that riboflavin was able to recognize G-T mismatch specifically and induce single-strand breaks in duplex DNA targets efficiently under irradiation. In the presence of riboflavin, the photo-irradiation could induce the death of tumor cells that are defective in mismatch repair system selectively, highlighting the G-T mismatch as potential drug target for tumor cells...
September 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28910508/immobilizing-organic-based-molecular-switches-into-metal-organic-frameworks-a-promising-strategy-for-switching-in-solid-state
#11
REVIEW
Bo Gui, Yi Meng, Yang Xie, Ke Du, Andrew C-H Sue, Cheng Wang
Organic-based molecular switches (OMS) are essential components for the ultimate miniaturization of nanoscale electronics and devices. For practical applications, it is often necessary for OMS to be incorporated into functional solid-state materials. However, the switching characteristics of OMS in solution are usually not transferrable to the solid state, presumably because of spatial confinement or inefficient conversion in densely packed solid phase. A promising way to circumvent this issue is harboring the functional OMS within the robust and porous environment of metal-organic frameworks (MOFs) as their organic components...
September 14, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28906571/photodynamic-therapy-for-glioblastoma-a-preliminary-approach-for-practical-application-of-light-propagation-models
#12
Clément Dupont, Anne-Sophie Vignion, Serge Mordon, Nicolas Reyns, Maximilien Vermandel
PURPOSE: Photodynamic therapy (PDT) is a promising treatment modality to be added in the management of glioblastoma multiforme (GBM). Light distribution modeling is required for planning and optimizing PDT. Several models have been developed to predict the light propagation inside biological tissues. In the present study, two analytical methods of light propagation emitted from a cylindrical fiber source were evaluated: a discrete and a continuous method. METHODS: The two analytical approaches were compared according to their fluence rate results...
September 14, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28905541/the-role-of-new-imaging-methods-in-managing-age-related-macular-degeneration
#13
Stephen James Talks, Akhunzada Muhammad Aftab, Imran Ashfaq, Taha Soomro
The use of imaging for age-related macular degeneration (AMD) depends on how it benefits clinical management and on reimbursement. The latter should relate to the former. This review assesses how different forms of AMD can be imaged and what information this provides. For nonneovascular AMD high-resolution optical coherence tomography (OCT), autofluorescence, and near infrared imaging can identify the type of drusen, such as reticular pseudodrusen, which influences prognosis, and the amount of atrophy, for which phase 3 trials are underway...
September 14, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28905336/endoscopic-ultrasonography-guided-photodynamic-therapy-for-recurrent-intraductal-papillary-mucinous-neoplasm-of-the-pancreas
#14
Sun-Ho Lee, Hoonsub So, Seungwhan Shin, Nah Kyum Lee, Do Hyun Park
No abstract text is available yet for this article.
September 13, 2017: Endoscopy
https://www.readbyqxmd.com/read/28905294/high-patient-satisfaction-with-daylight-activated-methyl-aminolevulinate-cream-in-the-treatment-of-multiple-actinic-keratoses-results-of-an-observational-study-in-australia
#15
Jo-Ann See, Kurt Gebauer, Jason K Wu, Shobhan Manoharan, Nabil Kerrouche, John Sullivan
INTRODUCTION: Actinic keratoses (AK) are treated to reduce the risk of progression to squamous cell carcinoma and for symptomatic and cosmetic benefits. The objective of this observational study was to generate real-life data on the use of daylight photodynamic therapy with methyl aminolevulinate cream (MAL DL-PDT) in treating mild to moderate facial/scalp AK. METHODS: A multicenter, prospective, observational study was conducted in Australia in patients receiving a single treatment of MAL DL-PDT for mild to moderate AK...
September 13, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28901740/inhibiting-metastasis-and-preventing-tumor-relapse-by-triggering-host-immunity-with-tumor-targeted-photodynamic-therapy-using-photosensitizer-loaded-functional-nanographenes
#16
Xinhe Yu, Duo Gao, Liquan Gao, Jianhao Lai, Chenran Zhang, Yang Zhao, Lijun Zhong, Bing Jia, Fan Wang, Xiaoyuan Chen, Zhaofei Liu
Effective cancer therapy depends not only on destroying the primary tumor, but also on conditioning the host immune system to recognize and eliminate residual tumor cells and prevent metastasis. In this study, a tumor integrin αvβ6-targeting peptide (the HK peptide)-functionalized graphene oxide (GO) was coated with a photosensitizer (HPPH). The resulting GO conjugate, GO(HPPH)-PEG-HK, was investigated whether it could destroy primary tumors and boost host antitumor immunity. We found that GO(HPPH)-PEG-HK exhibited significantly higher tumor uptake than GO(HPPH)-PEG and HPPH...
September 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/28899771/effectiveness-of-mechanical-debridement-with-and-without-adjunct-antimicrobial-photodynamic-therapy-in-the-treatment-of-periodontal-inflammation-among-patients-with-prediabetes
#17
Mansour Al-Askar, Abdulaziz A Al-Kheraif, Hameeda Bashir Ahmed, Sergio Varela Kellesarian, Hans Malmstrom, Fawad Javed
AIM: The aim of the present study was to assess the effectiveness of mechanical debridement (MD) with and without adjunct antimicrobial photodynamic therapy (aPDT) in the treatment of periodontal inflammation among patients with prediabetes. METHODS: Demographic information was collected using a questionnaire. Hemoglobin A1c (HbA1c) levels were measured at baseline and at 3 and 6 months' follow-up. TREATMENT: wise, individuals were randomly divided into 2 groups as follows: (a) Group-1, participants underwent full-mouth MD; and Group-2: participants underwent full-mouth MD with adjunct aPDT...
September 9, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28899098/heterodimers-made-of-upconversion-nanoparticles-and-metal-organic-frameworks
#18
Yifan Li, Zhenghan Di, Jinghong Gao, Ping Cheng, Chunzhi Di, Ge Zhang, Bei Liu, Xinghua Shi, Lingdong Sun, Lele Li, Chun-Hua Yan
Creating nanoparticle dimers has attracted extensive interest. However, it still remains a great challenge to synthesize heterodimers with asymmetric compositions and synergistically enhanced functions. In this work, we report the synthesis of high quality heterodimers composed of porphyrinic nanoscale metal-organic frameworks (nMOF) and lanthanide-doped upconversion nanoparticles (UCNPs). Due to the dual optical properties inherited from individual nanoparticles and their interactions, absorption of low energy photons by the UCNPs is followed by energy transfer to the nMOFs, which then undergo activation of porphyrins to generate singlet oxygen...
September 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28895715/a-pompon-like-runps-based-theranostic-nanocarrier-system-with-stable-photoacoustic-imaging-characteristic-for-accurate-tumor-detection-and-efficient-phototherapy-guidance
#19
Gengjia Chen, Meng Xu, Shuang Zhao, Jing Sun, Qianqian Yu, Jie Liu
Even though numerous therapeutic methods exist for cancer treatment, many fail to achieve ideal outcomes or have severe side effects. Here, we describe a theranostic nanocarrier system with improved tumor vasculature detection and tumor margin quantification that increases the accuracy and guidance efficiency of phototherapy. Novel pompon-like RuNPs with superb photothermal properties and high encapsulation efficiency were first synthesized via the polyol reducing method. Based on these RuNPs, we then developed a multifunctional theranostic system, pRu-pNIPAM@RBT, composed of poly(Nisopropylacrylamide) as the thermal-response switch and of [Ru(bpy)2(tip)]2+ as the photosensitizer of PDT and the contrast agent of biomedical imaging...
September 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28892021/near-infrared-triggered-photodynamic-therapy-toward-breast-cancer-cells-using-dendrimer-functionalized-upconversion-nanoparticles
#20
Bing-Yen Wang, Ming-Liang Liao, Guan-Ci Hong, Wen-Wei Chang, Chih-Chien Chu
Water-soluble upconversion nanoparticles (UCNPs) that exhibit significant ultraviolet, blue, and red emissions under 980-nm laser excitation were successfully synthesized for performing near infrared (NIR)-triggered photodynamic therapy (PDT). The lanthanide-doped UCNPs bearing oleate ligands were first exchanged by citrates to generate polyanionic surfaces and then sequentially encapsulated with NH₂-terminated poly(amido amine) (PAMAM) dendrimers (G4) and chlorine6 (Ce6) using a layer-by-layer (LBL) absorption strategy...
September 11, 2017: Nanomaterials
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