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Danggui buxue tang

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https://www.readbyqxmd.com/read/28951880/chinese-herbal-formula-modified-danggui-buxue-tang-attenuates-apoptosis-of-hematopoietic-stem-cells-in-immune-mediated-aplastic-anemia-mouse-model
#1
Jingwei Zhou, Xue Li, Peiying Deng, Yi Wei, Juan Liu, Meng Chen, Yamei Xu, Dongmei Zhang, Lingqun Zhu, Lixia Lou, Bin Dong, Qiushuo Jin, Limin Chai
A derivative formula, DGBX, which is composed of three herbs (Radix astragali, Radix Angelicae sinensis, and Coptis chinensis Franch), is derived from a famous Chinese herbal formula, Danggui Buxue Tang (DBT) (Radix astragali and Radix Angelicae sinensis). We aimed to investigate the effects of DGBX on the regulation of the balance between proliferation and apoptosis of hematopoietic stem cells (HSCs) due to the aberrant immune response in a mouse model of aplastic anemia (AA). Cyclosporine (CsA), an immunosuppressor, was used as the positive control...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28861164/danggui-buxue-tang-suppresses-high-glucose-induced-proliferation-and-extracellular-matrix-accumulation-of-mesangial-cells-via-inhibiting-lncrna-pvt1
#2
Rui Zhang, Jinbo Li, Tao Huang, Xiuge Wang
BACKGROUND: Danggui Buxue Tang (DBT), a traditional Chinese medicine decoction, has been proven to have satisfactory effects on treating diabetic nephropathy (DN). In this study, we explored the potential underlying mechanism of DBT in DN treatment. METHODS: The DBT-containning serum was prepared by intragastric administration with DBT for rats. The levels of fibronectin (FN), laminin (LN) and collagen IV (COL IV) and TGF-β1 protein secreted in cell culture medium were determined by ELISA assay...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28852418/danggui-buxue-tang-a-simple-chinese-formula-containing-astragali-radix-and-angelicae-sinensis-radix-stimulates-the-expressions-of-neurotrophic-factors-in-cultured-sh-sy5y-cells
#3
Amy G W Gong, Huai Y Wang, Tina T X Dong, Karl W K Tsim, Y Z Zheng
BACKGROUND: Danggui Buxue Tang (DBT), a phytoestrogen-enriched Chinese herbal formula, serves as dietary supplement in stimulating the "Blood" functions of menopausal women. In traditional Chinese medicine (TCM) theory, "Blood" has a strong relationship with brain activities. Previous studies supported that some ingredients of DBT possessed neuronal beneficial functions. Therefore, the neurotrophic function and the mechanistic action of DBT were systematically evaluated in cultured human neuroblastoma SH-SY5Y cells...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28683082/the-herbal-decoction-modified-danggui-buxue-tang-attenuates-immune-mediated-bone-marrow-failure-by-regulating-the-differentiation-of-t-lymphocytes-in-an-immune-induced-aplastic-anemia-mouse-model
#4
Peiying Deng, Xue Li, Yi Wei, Juan Liu, Meng Chen, Yamei Xu, Bin Dong, Lingqun Zhu, Limin Chai
Angelicae Sinensis, Radix Astragali and Rhizoma Coptidis are all herbs of modified Danggui Buxue Tang (DGBX) and are extensively applied herbs in traditional Chinese medicine for the treatment of anemia and inflammation. In this study, immune-induced AA mice were used as an animal model, and the immunosuppressive agent, Ciclosporin A (CsA), was used as a positive control. Multiple pro-inflammatory cytokines were examined by bead-based multiplex flow cytometry. The T-cell subsets were assessed using a fluorescence-activated cell sorter (FACS)...
2017: PloS One
https://www.readbyqxmd.com/read/28458344/effects-of-astragalus-combined-with-angelica-on-bone-marrow-hematopoiesis-suppression-induced-by-cyclophosphamide-in-mice
#5
Fei Li, Rong Tang, Ling-Bo Chen, Ke-Sheng Zhang, Xiao-Ping Huang, Chang-Qing Deng
Danggui Buxue Tang (DBT), a combination of Astragalus and Angelica at a 5 : 1 ratio, mainly promotes hematopoiesis. However, in the clinic, the combination ratio of Astragalus and Angelica to treat low hematopoietic function is not an absolute 5 : 1 ratio, suggesting that the herbs may promote hematopoiesis better after being combined at a certain range of ratios. The objective of this study is to investigate the effect of different ratio combinations of Astragalus and Angelica on bone marrow hematopoiesis suppression induced by cyclophosphamide (CTX) and to probe the interaction and mechanism of Astragalus combined with Angelica in promoting hematopoiesis...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28327640/compatibility-study-of-danggui-buxue-tang-on-chemical-ingredients-angiogenesis-and-endothelial-function
#6
Ping-Lan Lin, Zhi-Cheng Li, Rui-Fang Xie, You-Hua Wang, Xin Zhou
Danggui Buxue Tang (DBT) is a classic Chinese herbal formula which consists of Astragali mongholici Radix and Angelica sinensis Radix (ASR). For chemical ingredients, HPLC were performed. Results showed compared with single herbs, DBT decoction could promote the dissolution of ingredients such as ferulic acid and calycosin. Furthermore, when ratio of AMR to ASR was 5 to 1, synthetic score was the best. For angiogenesis, normal and injured zebrafish model were applied. Results showed DBT and its ingredients had angiogenesis effects on Sub Intestinal vessels (SIVs) of normal zebrafish...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28163116/danggui-buxue-tang-astragali-radix-and-angelicae-sinensis-radix-for-menopausal-symptoms-a-review
#7
REVIEW
Huang Q Lin, Amy G W Gong, Huai Y Wang, Ran Duan, Tina T X Dong, Kui J Zhao, Karl W K Tsim
BACKGROUND: Traditional Chinese medicine (TCM) has contributed greatly to human health in past several thousand years. Today, the development of TCM is facing two obstacles: (i) quality control of herbal extract; and (ii) action mechanisms not known. OBJECTIVES: Among thousands of complex TCM formulations, Danggui Buxue Tang (DBT) is the simplest one. DBT is used to treat ailments in women and contains only two herbs, Astragali Radix (Huangqi; AR) and Angelicae Sinensis Radix (Danggui; ASR)...
March 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27872860/danggui-buxue-tang-attenuates-tubulointerstitial-fibrosis-via-suppressing-nlrp3-inflammasome-in-a-rat-model-of-unilateral-ureteral-obstruction
#8
Linna Wang, Jiwei Ma, Cunxia Guo, Changyong Chen, Zhong Yin, Xueguang Zhang, Xiangmei Chen
Inflammation significantly contributes to the progression of chronic kidney disease (CKD). This study aimed to characterize Danggui Buxue Tang (DBT) renoprotection and relationship with NOD-like receptors family pyrin domain-containing 3 (NLRP3) inflammasome expression in rats with unilateral ureteral obstruction (UUO). Sprague-Dawley rats were subjected to UUO and randomly assigned to untreated UUO, enalapril-treated (10 mg/kg/day), and DBT-treated (9 g/kg/day) groups. Sham-operated rats served as controls, with 8 rats in each group...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27824860/ferulic-acid-orchestrates-anti-oxidative-properties-of-danggui-buxue-tang-an-ancient-herbal-decoction-elucidation-by-chemical-knock-out-approach
#9
Amy G W Gong, Vincent Y Huang, Huai Y Wang, Huang Q Lin, Tina T X Dong, Karl W K Tsim
Ferulic acid, a phenolic acid derived mainly from a Chinese herb Angelica Sinensis Radix (ASR), was reported to reduce the formation of free radicals. Danggui Buxue Tang (DBT), a herbal decoction composing of Astragali Radix (AR) and ASR, has been utilized for more than 800 years in China having known anti-oxidative property. Ferulic acid is a major active ingredient in DBT; however, the role of ferulic acid within the herbal mixture has not been resolved. In order to elucidate the function of ferulic acid within this herbal decoction, a ferulic acid-depleted herbal decoction was created and named as DBTΔfa...
2016: PloS One
https://www.readbyqxmd.com/read/27807897/polysaccharide-of-danggui-buxue-tang-an-ancient-chinese-herbal-decoction-induces-expression-of-pro-inflammatory-cytokines-possibly-via-activation-of-nf%C3%AE%C2%BAb-signaling-in-cultured-raw-264-7-cells
#10
Amy Gw Gong, Laura Ml Zhang, Candy Tw Lam, Miranda L Xu, Huai Y Wang, H Q Lin, Tina Tx Dong, Karl Wk Tsim
Danggui Buxue Tang (DBT) is an ancient Chinese herbal decoction containing two herbs, Astragali Radix (AR) and Angelicae Sinensis Radix (ASR): this herbal decoction serves as dietary supplement for women during menopause. DBT has been known to modulate immune responses, and its polysaccharide is proposed to be one of the active components. However, the polysaccharide-induced signaling in immune activation is not revealed. Here, we are identifying that the immune activation, triggered by DBT, could be mediated by polysaccharide...
February 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27284335/protective-effects-of-danggui-buxue-tang-on-renal-function-renal-glomerular-mesangium-and-heparanase-expression-in-rats-with-streptozotocin-induced-diabetes-mellitus
#11
Tai-Sheng Ye, Ying-Wen Zhang, Xian-Mei Zhang
Danggui Buxue Tang (DBT) is a simple combination of Radix Astragali and Radix Angelica sinensis (5:1), with a variety pharmacological activities. In the present study, a single intravenous injection of 30 mg/kg streptozotocin and subsequent six weeks of high glucose diet in Sprague Dawley rats were used to induce diabetic nephropathy. Rats with diabetes mellitus showed increased levels of fasting blood glucose (FBG), blood urea nitrogen (BUN), serum creatinine (Scr), serum and urine β2-microglobulins (β2-MG), and type IV collagen (all P<0...
June 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27196297/the-estrogenic-properties-of-danggui-buxue-tang-a-chinese-herbal-decoction-are-triggered-predominantly-by-calycosin-in-mcf-7-cells
#12
COMPARATIVE STUDY
Amy G W Gong, Kei M Lau, Miranda L Xu, Huang Q Lin, Tina T X Dong, Ken Y Z Zheng, K J Zhao, Karl W K Tsim
BACKGROUND: Danggui Buxue Tang (DBT), a Chinese herbal decoction containing Astragali Radix (AR; roots of Astragalus memebranaceus (Fisch.) Bunge var. mongholicus (Bunge) Hsiao) and Angelicae Sinensis Radix (ASR; roots of Angelica sinensis Oliv.) at a weight ratio of 5:1, is used to improve menopausal syndromes in women. Several lines of evidence indicate that DBT has strong estrogenic property; however, the action mechanism of this herbal decoction is not known. Calycosin, a major flavonoid in AR, shares similar structure with β-estradiol, and thus which is hypothesized to be the key compound of DBT in responsible for such estrogenic properties...
August 2, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26824621/danggui-buxue-tang-chinese-herbal-decoction-containing-astragali-radix-and-angelicae-sinensis-radix-induces-production-of-nitric-oxide-in-endothelial-cells-signaling-mediated-by-phosphorylation-of-endothelial-nitric-oxide-synthase
#13
Amy G W Gong, K M Lau, Laura M L Zhang, H Q Lin, Tina T X Dong, Karl W K Tsim
Danggui Buxue Tang, an ancient Chinese herbal decoction containing Astragali Radix and Angelicae Sinensis Radix at the weight ratio of 5:1, is used to mitigate menopausal syndromes in women. The pharmacological properties of Danggui Buxue Tang have been illustrated in bone development, blood enhancement, and immune stimulation. Here, we extended the possible pharmacological role of Danggui Buxue Tang in cardiovascular function. In cultured human umbilical vein endothelial cells, the application of Danggui Buxue Tang induced the release of nitric oxide and the phosphorylation of endothelial nitric oxide synthase and Akt kinase in time- and dose-dependent manners...
March 2016: Planta Medica
https://www.readbyqxmd.com/read/26732632/evaluation-of-safety-of-modified-danggui-buxue-tang-in-rodents-immunological-toxicity-and-hormonal-aspects
#14
Jian-Hui Xie, Zhi-Wei Chen, Ya-Wei Pan, De-Min Luo, Zi-Ren Su, Hai-Ming Chen, Zhen Qin, Shui-Qing Huang, Gao Lei
ETHNOPHARMACOLOGICAL RELEVANCE: Radix Astragali (RA), Radix Angelicae Sinensis (RAS) and Folium Epimedii (FE) are three of the extensively applied herbs among traditional Chinese medicines for gynecological disorders and osteoporosis. A derivative herbal formula-RRF, consisting of the three medicines with a weight ratio of 5:1:5, is derived from a famous Chinese herbal formula-Danggui Buxue Tang (DBT). RRF has shown noteworthy perimenopause ameliorating effect in both ovariectomized rats and natural aging female rats, which might represent a promising candidate for the treatment of perimenopausal disorders...
May 13, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26347805/total-glucosides-of-danggui-buxue-tang-attenuate-blm-induced-pulmonary-fibrosis-via-regulating-oxidative-stress-by-inhibiting-nox4
#15
Ping Zhao, Wen-Cheng Zhou, De-Lin Li, Xiao-Ting Mo, Liang Xu, Liu-Cheng Li, Wen-Hui Cui, Jian Gao
Pulmonary fibrosis (PF) is a serious chronic lung disease with unknown pathogenesis. Researches have confirmed that oxidative stress which is regulated by NADPH oxidase-4 (NOX4), a main source of reactive oxygen species (ROS), is an important molecular mechanism underlying PF. Previous studies showed that total glucosides of Danggui Buxue Tang (DBTG), an extract from a classical traditional Chinese herbal formula, Danggui Buxue Tang (DBT), attenuated bleomycin-induced PF in rats. However, the mechanisms of DBTG are still not clear...
2015: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/26126113/enhanced-bone-tissue-regeneration-by-porous-gelatin-composites-loaded-with-the-chinese-herbal-decoction-danggui-buxue-tang
#16
Wen-Ling Wang, Shi-Yuan Sheu, Yueh-Sheng Chen, Shung-Te Kao, Yuan-Tsung Fu, Tzong-Fu Kuo, Kuo-Yu Chen, Chun-Hsu Yao
Danggui Buxue Tang (DBT) is a traditional Chinese herbal decoction containing Radix Astragali and Radix Angelicae sinensis. Pharmacological results indicate that DBT can stimulate bone cell proliferation and differentiation. The aim of the study was to investigate the efficacy of adding DBT to bone substitutes on bone regeneration following bone injury. DBT was incorporated into porous composites (GGT) made from genipin-crosslinked gelatin and β-triclacium phosphates as bone substitutes (GGTDBT). The biological response of mouse calvarial bone to these composites was evaluated by in vivo imaging systems (IVIS), micro-computed tomography (micro-CT), and histology analysis...
2015: PloS One
https://www.readbyqxmd.com/read/25861366/danggui-buxue-tang-inhibits-2-4-dinitrochlorobenzene-induced-atopic-dermatitis-in-mice
#17
Li-Wen Fang, Chao-Chun Cheng, Tzann-Shun Hwang, Wen-Chung Huang, Chian-Jiun Liou, Wen-Chyuan Chen, Shu-Ju Wu
Danggui Buxue Tang (DBT) is a herbal decoction that has been used in Chinese medicine to enhance qi and blood circulation. Previously, we found that DBT can suppress allergy-related asthma in mice, leading us to hypothesize that DBT might ameliorate allergy disease. In this study, we evaluated whether DBT can attenuate atopic dermatitis (AD) symptoms and have an anti-inflammatory effect on AD-like mice. The dorsal skin of female mice was shaved and sensitized cutaneously (skin smear) with 1-chloro-2,4-dinitrobenzene...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/25796405/calycosin-orchestrates-the-functions-of-danggui-buxue-tang-a-chinese-herbal-decoction-composing-of-astragali-radix-and-angelica-sinensis-radix-an-evaluation-by-using-calycosin-knock-out-herbal-extract
#18
REVIEW
Amy Guo-wei Gong, Ning Li, Kei-man Lau, Pinky Sum-chi Lee, Lu Yan, Miranda Li Xu, Candy Ting-wai Lam, Ava Yeung-yeung Kong, Huang-quan Lin, Tina Ting-xia Dong, Karl Wah-keung Tsim
ETHNOPHARMACOLOGICAL RELEVANCE: Danggui Buxue Tang (DBT) is a classical Chinese herbal decoction containing two herbs, Astragali Radix (AR) and Angelicae Sinensis Radix (ASR), which serves as dietary supplement for treating women menopausal syndromes. Pharmacological studies indicate that DBT has estrogenic, erythropoietic and osteogenic properties; however, the action mechanism for this complex herbal decoction is not known. Calycosin, a major flavonoid in AR, shares similar structure with β-estradiol, and thus which is hypothesized to be the critical compound of DBT...
June 20, 2015: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/25295277/evaluating-the-bone-tissue-regeneration-capability-of-the-chinese-herbal-decoction-danggui-buxue-tang-from-a-molecular-biology-perspective
#19
Wen-Ling Wang, Shi-Yuan Sheu, Yueh-Sheng Chen, Shung-Te Kao, Yuan-Tsung Fu, Tzong-Fu Kuo, Kuo-Yu Chen, Chun-Hsu Yao
Large bone defects are a considerable challenge to reconstructive surgeons. Numerous traditional Chinese herbal medicines have been used to repair and regenerate bone tissue. This study investigated the bone regeneration potential of Danggui Buxue Tang (DBT), a Chinese herbal decoction prepared from Radix Astragali (RA) and Radix Angelicae Sinensis (RAS), from a molecular biology perspective. The optimal ratio of RA and RAS used in DBT for osteoblast culture was obtained by colorimetric and alkaline phosphatase (ALP) activity assays...
2014: BioMed Research International
https://www.readbyqxmd.com/read/25214874/functions-of-danggui-buxue-tang-a-chinese-herbal-decoction-containing-astragali-radix-and-angelicae-sinensis-radix-in-uterus-and-liver-are-both-estrogen-receptor-dependent-and-independent
#20
Oliver Zierau, Ken Y Z Zheng, Anja Papke, Tina T X Dong, Karl W K Tsim, Günter Vollmer
Danggui Buxue Tang (DBT), a herbal decoction containing Astragali Radix (AR) and Angelicae Sinensis Radix (ASR), has been used in treating menopausal irregularity in women for more than 800 years in China. Pharmacological results showed that DBT exhibited significant estrogenic properties in vitro, which therefore suggested that DBT could activate the nuclear estrogen receptors. Here, we assessed the estrogenic properties of DBT in an ovariectomized in vivo rat model: DBT was applied to the ovariectomized rats for 3 days...
2014: Evidence-based Complementary and Alternative Medicine: ECAM
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