Nikolai Litviakov, Marina Ibragimova, Matvey Tsyganov, Polina Kazantseva, Irina Deryusheva, Alina Pevzner, Artem Doroshenko, Eugeny Garbukov, Natalia Tarabanovskaya, Elena Slonimskaya
INTRODUCTION: The phenomenon of non-CSC (cancer stem cell) to CSC plasticity has been previously described in multiple studies and occurs during the ectopic expression of stemness genes such as OCT3 , SOX2 , KLF4 , MYC , NOTCH1 , and NANOG . In our opinion, acquiring the ability to ectopically express stemness genes, selected by bioinformatics analysis and, accordingly, non-CSC to CSC plasticity, is due to amplification of genes at the following locations: 3q, 5p, 6p, 7q, 8q, 13q, 9p, 9q, 10p, 10q21...
May 26, 2020: Oncotarget