Patrick Thon, Tim Rahmel, Dominik Ziehe, Lars Palmowski, Britta Marko, Hartmuth Nowak, Alexander Wolf, Andrea Witowski, Jennifer Orlowski, Björn Ellger, Frank Wappler, Elke Schwier, Dietrich Henzler, Thomas Köhler, Alexander Zarbock, Stefan Felix Ehrentraut, Christian Putensen, Ulrich Hermann Frey, Moritz Anft, Nina Babel, Barbara Sitek, Michael Adamzik, Lars Bergmann, Matthias Unterberg, Björn Koos, Katharina Rump
Sepsis involves an immunological systemic response to a microbial pathogenic insult, leading to a cascade of interconnected biochemical, cellular, and organ-organ interaction networks. Potential drug targets can depict aquaporins, as they are involved in immunological processes. In immune cells, AQP3 and AQP9 are of special interest. In this study, we tested the hypothesis that these aquaporins are expressed in the blood cells of septic patients and impact sepsis survival. Clinical data, routine laboratory parameters, and blood samples from septic patients were analyzed on day 1 and day 8 after sepsis diagnosis...
January 19, 2024: International Journal of Molecular Sciences