Alessia Gallucci, Erica Varoli, Lilia Del Mauro, Gabriel Hassan, Margherita Rovida, Angela Comanducci, Silvia Casarotto, Vincenzina Lo Re, Leonor J Romero Lauro
The limits of the standard, behaviour-based clinical assessment of patients with disorders of consciousness (DoC) prompted the employment of functional neuroimaging, neurometabolic, neurophysiological and neurostimulation techniques, to detect brain-based covert markers of awareness. However, uni-modal approaches, consisting in employing just one of those techniques, are usually not sufficient to provide an exhaustive exploration of the neural underpinnings of residual awareness. This systematic review aimed at collecting the evidence from studies employing a multimodal approach, that is, combining more instruments to complement DoC diagnosis, prognosis and better investigating their neural correlates...
December 23, 2023: European Journal of Neuroscience