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Negative effects of famotidine

Xiu-Xia Wu, Xian Li, Zhong-Qin Dang, Wen-Zhao Luo, Chang-Pu Zhao, Kun Yu
To explore the therapeutic effect and security of Zisheng decoction recipein treatment of the chronic atrophic gastritis (CAG) with intestinal metaplasia(IM). A total of 147 eligible cases were randomly divided into the traditional Chinese medicine group, Western medicine group and the combined group,47 cases in each group. Zisheng decoction recipe, famotidine, as well as Zisheng decoction recipe + famotidine were respectively given in the above three groups, with a treatment course of 30 d. The symptoms of traditional Chinese medicine, pathological score of gastric mucosa and the negative rate of Helicobacter pylori before and after treatment were observed in each group...
December 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Francis K L Chan, Moe Kyaw, Tetsuya Tanigawa, Kazuhide Higuchi, Kazuma Fujimoto, Pui Kuan Cheong, Vivian Lee, Yoshikazu Kinoshita, Yuji Naito, Toshio Watanabe, Jessica Y L Ching, Kelvin Lam, Angeline Lo, Heyson Chan, Rashid Lui, Raymond S Y Tang, Yasuhisa Sakata, Yee Kit Tse, Toshihisa Takeuchi, Osamu Handa, Hiroko Nebiki, Justin C Y Wu, Takashi Abe, Tsuyoshi Mishiro, Siew C Ng, Tetsuo Arakawa
BACKGROUND & AIMS: It is not clear whether H2 -receptor antagonists (H2RAs) reduce the risk of gastrointestinal (GI) bleeding in aspirin users at high risk. We performed a double-blind randomized trial to compare the effects of a proton pump inhibitor (PPI) vs a H2RA antagonist in preventing recurrent upper GI bleeding and ulcers in high-risk aspirin users. METHODS: We studied 270 users of low-dose aspirin (≤325 mg/day) with a history of endoscopically confirmed ulcer bleeding at 8 sites in Hong Kong and Japan...
January 2017: Gastroenterology
Takahiro Uotani, Mitsushige Sugimoto, Masafumi Nishino, Hitomi Ichikawa, Shu Sahara, Mihoko Yamade, Moriya Iwaizumi, Takanori Yamada, Satoshi Osawa, Ken Sugimoto, Kazuo Umemura, Hiroshi Watanabe, Hiroaki Miyajima, Takahisa Furuta
Anti-platelet drug-induced gastric mucosal injury correlates with intragastric pH. Our aim was to investigate prophylaxis effects of famotidine, one of the representative histamine-2 receptor antagonists (H2RA), on gastric mucosal injury induced by dual therapy with low-dose aspirin and clopidogrel in relation to Helicobacter pylori (H. pylori) infection and CYP2C19 genotypes. This study was conducted for 20 healthy Japanese volunteers (10 H. pylori-positive and 10-negative subjects) with 100 mg aspirin plus 75 mg clopidogrel (AC) once-daily dosing and AC plus 20 mg famotidine twice-daily dosing (ACH)...
August 2014: Journal of Clinical Pharmacology
Jodie Pang, Gena Dalziel, Brian Dean, Joseph A Ware, Laurent Salphati
Changes in gastric pH can impact the dissolution and absorption of compounds presenting pH-dependent solubility. We assessed, in dogs, the effects of gastric pH-modifying agents on the oral absorption of two weakly basic anticancer drugs, dasatinib and GDC-0941. We also tested whether drug-induced hypochlorhydria could be temporarily mitigated using betaine HCl. Pretreatments with pentagastrin, famotidine, betaine HCl, or combinations of famotidine and betaine HCl were administered orally to dogs prior to drug dosing...
November 4, 2013: Molecular Pharmaceutics
Katarina Meskanen, Heidi Ekelund, Jarmo Laitinen, Pertti J Neuvonen, Jari Haukka, Pertti Panula, Jesper Ekelund
Histamine has important functions as regulator of several other key neurotransmitters. Patients with schizophrenia have lower histamine H1 receptor levels. Since a case report in 1990 of an effect of the H2 antagonist famotidine on negative symptoms in schizophrenia, some open-label trials have been performed, but no randomized controlled trial. Recently, it was shown that clozapine is a full inverse agonist at the H2 receptor. We performed a researcher-initiated, academically financed, double-blind, placebo-controlled, parallel-group, randomized trial with the histamine H2 antagonist famotidine in treatment-resistant schizophrenia...
August 2013: Journal of Clinical Psychopharmacology
Akira Tamura, Kazunari Murakami, Junichi Kadota
BACKGROUND: The preventive effects of histamine 2 receptor antagonists vs. proton pump inhibitors on low-dose aspirin (LDA)-related gastroduodenal mucosal injury have not been fully investigated. We conducted a cross-sectional study to compare the prevalence of gastroduodenal ulcers or erosions in patients taking LDA with either 40 mg/day of famotidine or 15 mg/day of lansoprazole for at least three months. METHODS: Of 84 eligible patients, two taking 40 mg/day of famotidine and four taking 15 mg/day of lansoprazole refused to undergo upper gastrointestinal endoscopy...
2013: BMC Research Notes
K Aouam, W Bouida, N Ben Fredj, A Chaabane, H Boubaker, R Boukef, N A Boughattas, S Nouira
WHAT IS KNOWN AND OBJECTIVE: Ranitidine is a generally well-tolerated drug, and serious side effects are rare. However, ranitidine-induced anaphylaxis has been reported on rare occasions. We report on such a case and review other cases reported in the literature. CASE SUMMARY: A 36-year-old man with no history of other medications, illnesses or allergic diseases, especially to drugs, consulted our emergency department because of renal colic and epigastric discomfort...
August 2012: Journal of Clinical Pharmacy and Therapeutics
Masafumi Nishino, Mitsushige Sugimoto, Chise Kodaira, Mihoko Yamade, Takahiro Uotani, Naohito Shirai, Mutsuhiro Ikuma, Tatsuo Tanaka, Haruhiko Sugimura, Akira Hishida, Takahisa Furuta
The preventive effects of lansoprazole and famotidine on low-dose aspirin-induced gastric mucosal injury in relation to gastric acidity were compared in healthy Japanese volunteers. Fifteen Helicobacter pylori-negative volunteers with different CYP2C19 genotypes were randomly administered aspirin 100 mg, aspirin plus famotidine 20 mg twice daily, or aspirin plus lansoprazole 15 mg once daily for 7 days each in a crossover fashion. Gastroscopy for the evaluation of mucosal injury based on modified Lanza score (MLS) and 24-hour intragastric pH monitoring were performed on day 7 of each regimen...
July 2011: Journal of Clinical Pharmacology
Lawrence Maayan, Julia Vakhrusheva, Christoph U Correll
Antipsychotic-related weight gain and metabolic effects are a critical outcome for patients requiring these medications. A literature search using MEDLINE, Web of Science, PsycNET, and EMBASE for randomized, open and double-blind, placebo-controlled trials of medications targeting antipsychotic-induced weight gain was performed. Primary outcome measures were change and endpoint values in body weight and body mass index (BMI). Secondary outcomes included >or=7% weight gain, all-cause discontinuation, change in waist circumference, glucose and lipid metabolism parameters, and psychiatric symptoms...
June 2010: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Hiroshi Iida, Masahiko Inamori, Keiko Akimoto, Hironori Mawatari, Hiroki Endo, Yuichi Nozaki, Tomoyuki Akiyama, Tamon Ikeda, Yasunari Sakamoto, Koji Fujita, Kyoko Yoneda, Hirokazu Takahashi, Masato Yoneda, Ayumu Goto, Yasunobu Abe, Noritoshi Kobayashi, Hiroyuki Kirikoshi, Kensuke Kubota, Satoru Saito, Atsushi Nakajima
BACKGROUND/AIMS: The ideal medication for treatment of acid related diseases should have a rapid onset of action to promote hemostasis. The aim of our study was to investigate the inhibitory effects on gastric acid secretion after single intravenous administrations of lansoprazole 30 mg and famotidine 20 mg. METHODOLOGY: Twelve Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 4 hours after single intravenous administration of lansoprazole 30 mg or famotidine 20 mg...
March 2009: Hepato-gastroenterology
Yuji Naito, Shoji Iinuma, Nobuaki Yagi, Yoshio Boku, Eiko Imamoto, Tomohisa Takagi, Osamu Handa, Satoshi Kokura, Toshikazu Yoshikawa
The clinical efficacy of gastroprotective drugs or low-dose H(2) receptor antagonists in the prevention of nonsteroidal anti-inflammatory drug (NSAID)-induced gastropathy is limited. The aim of the present study was to investigate efficacy of rebamipide and famotidine in Helicobacter pylori (H. pylori)-negative healthy volunteers taking NSAID. This study was a randomized, two way crossover study comparing the preventive effect rebamipide 100 mg, t.i.d. and famotidine 10 mg, b.i.d against indomethacin (25 mg, t...
July 2008: Journal of Clinical Biochemistry and Nutrition
Shinichiro Tanaka, Kazuhiko Nishigaki, Shinsuke Ojio, Munenori Okubo, Shinji Yasuda, Yoshiyuki Ishihara, Tomoki Kubota, Nobuhiro Takasugi, Itta Kawamura, Takahiko Yamaki, Hiroaki Ushikoshi, Takuma Aoyama, Masanori Kawasaki, Genzou Takemura, Shinya Minatoguchi
BACKGROUND: Aspirin and anti-platelet drugs are used commonly for patients with coronary heart disease. Proton pump inhibitor (PPI) and high-dose H2-blocker were recommended for preventing NSAIDs-related ulcer. Previously H2-blocker reported to have some negative cardiovascular effects. Additionally, a recent in vitro study showed that PPI reduced cardiac contractility. In this study, we evaluated whether chronic administration of PPI and high-dose H2-blocker affects left ventricular function...
August 2008: Journal of Cardiology
Michael S Leib, Robert B Duncan, Daniel L Ward
BACKGROUND: Helicobacter pylori is a common cause of gastritis and peptic ulcers in humans. Many dogs, including those with gastritis and chronic vomiting, are infected with Helicobacter spp. HYPOTHESIS: Triple antimicrobial therapy will eradicate Helicobacter infection, improve gastritis, and reduce clinical signs. The addition of acid suppression medication will not improve results. ANIMALS: Twenty-four pet dogs with chronic vomiting and gastric Helicobacter spp...
November 2007: Journal of Veterinary Internal Medicine
Tomoyuki Koike, Shuichi Ohara, Hitoshi Sehine, Masashi Kawamura, Yasuhiko Abe, Yoshifumi Inomata, Katsunori Iijima, Akira Imatani, Tooru Shimosegawa
BACKGROUND/AIMS: There has been no study attempting to compare the effects of lafutidine, a novel H2-receptor antagonist and other H2-receptor antagonists in the same subjects and relating them to H. pylori status. The first aim of this study was to investigate the effect of H. pylori status on intragastric pH in healthy volunteers receiving lafutidine or famotidine. The second aim was to compare the effects of the two antisecretory drugs. METHODOLOGY: The study was carried out in 11 healthy asymptomatic male volunteers...
June 2007: Hepato-gastroenterology
M Saeed Arayne, Najma Sultana, Urooj Haroon, Erum Hamza
Enoxacin is a second-generation quinolone with increased antibacterial activity both in potency as well as in terms of broad spectrum against a wide range of clinically important pathogens over the first generation quinolones and produces its effect by inhibiting bacterial enzyme DNA gyrase. There are a number of drug interactions reported for enoxacin. On the other hand H2-receptor antagonists block gastric acid secretion and some cardiovascular effects of histamine. As the later drugs are used for a long-term therapy, they may be coadministered with other drugs...
July 2007: Pakistan Journal of Pharmaceutical Sciences
Lars Fändriks, Hans Lönroth, Anders Pettersson, Nimish Vakil
OBJECTIVE: Prompt and long-standing acid control following once-daily administration of antisecretory drugs is desirable. The objective of this study was to determine whether co-administration of a well-characterized H2-receptor antagonist, famotidine, can be combined with the proton-pump inhibitor omeprazole. MATERIAL AND METHODS: Intragastric 24-h pH-metry was performed in healthy, Helicobacter pylori-negative volunteers on day 1 and after 8 days of daily administration of 20 mg omeprazole, 10 mg famotidine, or a combination of these in a three-way crossover design...
June 2007: Scandinavian Journal of Gastroenterology
Yoshimi Hashimoto, Chiharu Matsunaga, Emi Tokuyama, Eriko Tsuji, Takahiro Uchida, Hiroaki Okada
The purpose of the present study was the quantitative prediction of the bitterness-suppressing effect of sweeteners (sucrose or sugar alcohols) on the bitterness of famotidine (or quinine sulfate as control) solutions using an artificial taste sensor. Firstly, we examined the response characteristics of the sensor response to sweetness. The sensor membrane is charged negatively in the presence of sweeteners, which tend to receive protons from one of the components of the sensor membrane. The magnitude of the sensor response was shown to increase in direct proportion to the concentration of the sweetener...
May 2007: Chemical & Pharmaceutical Bulletin
Tomohiko Shimatani, Masaki Inoue, Tomoko Kuroiwa, Mutsuko Moriwaki, Jing Xu, Kazuro Ikawa, Norifumi Morikawa, Susumu Tazuma
Low-dose omeprazole is superior to full-dose famotidine in maintenance therapy for gastroesophageal reflux disease, whereas "on-demand" famotidine is more effective for relief of episodes of heartburn. To explain this apparent discrepancy, intragastric pH was measured for 24-hr seven times in eight Japanese Helicobacter pylori-negative cytochrome P450 2C19 extensive metabolizers; on Days 1, 8, and 15 of repeated administration of 10 mg of omeprazole once daily and of 20 mg of famotidine twice daily and before medication...
February 2007: Digestive Diseases and Sciences
Kenji Furuta, Kyoichi Adachi, Yoshinori Komazawa, Takafumi Mihara, Masaharu Miki, Takane Azumi, Tomoo Fujisawa, Tomoko Katsube, Yoshikazu Kinoshita
BACKGROUND AND AIM: The attenuated antisecretory activity of H2 receptor antagonists (H2RA) during continuous administration is known as the tolerance phenomenon. The authors recently clarified that presence or absence of Helicobacter pylori infection influences the occurrence of the tolerance phenomenon. The aim of this study was to clarify whether tolerance to H2RA is correlated with attenuation of the inhibitory effect against gastroesophageal acid reflux in patients with gastroesophageal reflux disease (GERD)...
October 2006: Journal of Gastroenterology and Hepatology
Shigeyoshi Gon, Yoshihito Irie, Morio Takahashi
OBJECTIVES: Upper gastrointestinal bleeding, particularly from a stress-induced duodenal ulcer, is an extremely important perioperative complication in cardiovascular surgery. METHODS: In the present study, 33 patients undergoing elective open heart surgery between July 2000 and February 2001 were allocated to either a famotidine (FAM) or rabeprazole (RPZ) group to examine the perioperative gastric and esophageal pH readings, in conjunction with an investigation into the effect of infection with Helicobacter pylori (HP)...
July 2006: Japanese Journal of Thoracic and Cardiovascular Surgery
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