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Insomnia from statins

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https://www.readbyqxmd.com/read/25439449/safety-profile-of-subjects-treated-to-very-low-low-density-lipoprotein-cholesterol-levels-30-mg-dl-with-rosuvastatin-20-mg-daily-from-jupiter
#1
RANDOMIZED CONTROLLED TRIAL
Brendan M Everett, Samia Mora, Robert J Glynn, Jean MacFadyen, Paul M Ridker
Recent US guidelines expand the indications for high-intensity statin therapy, yet data on the safety of attaining very low-density lipoprotein cholesterol (LDL-C) levels are scarce. Among 16,304 participants in the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) with on-treatment LDL-C levels, we identified 767 who did and 7,387 who did not achieve LDL-C <30 mg/dl on rosuvastatin 20 mg daily and 718 participants who did and 7,436 who did not achieve LDL-C reductions of ≥70% on rosuvastatin, and 8,150 allocated to placebo...
December 1, 2014: American Journal of Cardiology
https://www.readbyqxmd.com/read/24743876/association-of-statin-use-with-sleep-disturbances-data-mining-of-a-spontaneous-reporting-database-and-a-prescription-database
#2
Mitsutaka Takada, Mai Fujimoto, Kohei Yamazaki, Masashi Takamoto, Kouichi Hosomi
BACKGROUND: Particular interest has been generated regarding the possible influence of statin use on sleep quality. However, no conclusive evidence exists that a particular statin is more likely to be associated with sleep disturbances versus others. It remains uncertain whether different statins produce different risks for sleep disturbance. OBJECTIVE: To examine the association between statin use and the risk of sleep disturbances, we conducted data mining using the US Food and Drug Administration Adverse Event Reporting System (FAERS) and a large organized database of prescriptions constructed by a database vendor (Japan Medical Information Research Institute, Inc...
June 2014: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/23312495/-systemic-glucocorticoid-therapy-associated-measures
#3
REVIEW
L Sailler, G Pugnet, P Arlet
Long-term treatment with glucocorticoids results in many adverse effects. Prevention of osteoporosis is well codified, but prevention of other adverse effects is not. If there is some consensus on the prevention of glucocorticoid-induced adverse events, there are also many habits since interventional studies are lacking. A low caloric and low carbohydrate diet as well as a regular physical training are certainly necessary to avoid lipodystrophy, weight gain and diabetes mellitus. Some patients benefit from the repeated intervention of a dietetic or nutrition specialist...
May 2013: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/19489170/safety-profile-of-fluvastatin
#4
T K Peters
Statins are regarded as a well-tolerated class of drugs, particularly when compared with some of the older lipid-modifying agents, which have poor rates of compliance. Despite some early concern, the incidence of lens opacities observed in clinical studies involving statin use is no different from that in a normal ageing population. Similarly, the occurrence of insomnia with lipophilic agents appears to have been overemphasised and is not a clinically significant problem, irrespective of the statin under study...
December 1994: British Journal of Clinical Practice. Supplement
https://www.readbyqxmd.com/read/19026028/statin-associated-psychiatric-adverse-events-a-case-non-case-evaluation-of-an-italian-database-of-spontaneous-adverse-drug-reaction-reporting
#5
Marco Tuccori, Francesco Lapi, Arianna Testi, Daniela Coli, Ugo Moretti, Alfredo Vannacci, Domenico Motola, Francesco Salvo, Alma Lisa Rivolta, Corrado Blandizzi, Alessandro Mugelli, Mario Del Tacca
BACKGROUND: The inhibitors of HMG-CoA reductase ('statins') are widely prescribed hypolipidaemic drugs, which have been evaluated in several clinical trials involving hundreds of thousands of patients. From a safety perspective, both clinical trials and post-marketing surveillance have demonstrated that statins are generally well tolerated, with rare serious adverse drug reactions (ADRs) that affect mainly muscle, liver and kidney. However, recent interest has been focused on a potential risk of psychiatric ADRs associated with statins, including memory loss, depression, suicidality, aggression and antisocial behaviour...
2008: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/17535079/comparison-of-the-effects-of-policosanol-and-atorvastatin-on-lipid-profile-and-platelet-aggregation-in-patients-with-dyslipidaemia-and-type-2-diabetes-mellitus
#6
Gladys Castaño, Lilia Fernández, Rosa Mas, José Illnait, Meylin Mesa, J C Fernández
BACKGROUND: Diabetes mellitus and hypercholesterolaemia increase the risk for coronary heart disease, with type 2 diabetes mellitus being the most prevalent form of diabetes, frequently accompanied by dyslipidaemia. The main goal of dyslipidaemia control in nondiabetic and diabetic patients is to lower elevated low-density lipoprotein-cholesterol (LDL-C) levels. Policosanol is a cholesterol-lowering drug, purified from sugarcane wax, with a therapeutic range of 5-20 mg/day, which significantly reduces LDL-C levels...
2003: Clinical Drug Investigation
https://www.readbyqxmd.com/read/8729586/safety-profile-of-fluvastatin
#7
REVIEW
T K Peters
Statins are regarded as a well-tolerated class of drugs, particularly when compared with some of the older lipid-modifying agents, which have poor rates of compliance. Despite some early concern, the incidence of lens opacities observed in clinical studies involving statin use is no different from that in a normal ageing population. Similarly, the occurrence of insomnia with lipophilic agents appears to have been overemphasised and is not a clinically significant problem, irrespective of the statin under study...
January 1996: British Journal of Clinical Practice. Supplement
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