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Keiji Matsumoto, Yoshitaka Suetsugu, Yoshiaki Tanaka, Toyomi Kotaki, Shin G Goto, Tetsuro Shinoda, Sakiko Shiga
Juvenile hormone (JH) biosynthesis is inhibited under short-day conditions in the brown-winged green bug Plautia stali. We investigated allatostatic molecules in the brain of P. stali. Methanol brain extracts strongly inhibited JH biosynthesis. The allatostatic activities of the brain extracts were heat stable but gently suppressed by trypsin treatment, indicating that the allatostatic molecules were peptides. Grybi-MIP1, found in Gryllus bimaculatus as an allatostatic molecule, inhibited JH biosynthesis in P...
October 14, 2016: Journal of Insect Physiology
Maryam Beheshtian, Mojgan Babanejad, Hela Azaiez, Niloofar Bazazzadegan, Diana Kolbe, Christina Sloan-Heggen, Sanaz Arzhangi, Kevin Booth, Marzieh Mohseni, Kathy Frees, Mohammad Hossein Azizi, Ahmad Daneshi, Mohammad Farhadi, Kimia Kahrizi, Richard Jh Smith, Hossein Najmabadi
A significant contribution to the causes of hereditary hearing impairment comes from genetic factors. More than 120 genes and 160 loci have been identified to be involved in hearing impairment. Given that consanguine populations are more vulnerable to most inherited diseases, such as hereditary hearing loss (HHL), the genetic picture of HHL among the Iranian population, which consists of at least eight ethnic subgroups with a high rate of intermarriage, is expected to be highly heterogeneous. Using an electronic literature review through various databases such as PubMed, MEDLINE, and Scopus, we review the current picture of HHL in Iran...
October 1, 2016: Archives of Iranian Medicine
Yohei Kawano, Georg Petkau, Ingrid Wolf, Julia Tornack, Fritz Melchers
Long-term proliferating, DH JH -rearranged mouse precursor B-cell lines have previously been established in serum- and IL-7-containing media from fetal liver, but not from bone marrow. Serum and stromal cells expose these pre-B cells to undefined factors, hampering accurate analyses of ligand-dependent signalling, which controls pre-B cell proliferation, survival, residence and migration. Here, we describe a novel serum-free, stromal cell-free culture system, which allows to establish and maintain pre-B cells not only from fetal liver, but also from bone marrow with practically identical efficiencies in proliferation, cloning and differentiation...
October 14, 2016: European Journal of Immunology
Loukas Koyonos, Matthew J Kraeutler, Daniel F O'Brien, Michael G Ciccotti, Christopher C Dodson
OBJECTIVES: Generalized joint laxity has been proposed as a significant risk factor for failure after arthroscopic anterior shoulder stabilization. The purpose of this study was to prospectively measure joint mobility in patients undergoing arthroscopic anterior shoulder stabilization and to determine whether hypermobility is a risk factor for worse outcomes compared with patients having normal joint mobility. METHODS: Patients with anterior shoulder instability were prospectively enrolled...
October 13, 2016: Physician and Sportsmedicine
Denyse Cavalcante Lago, Fernanda Carvalho Humann, Angel Roberto Barchuk, Kuruvilla Joseph Abraham, Klaus Hartfelder
Adult honey bee queens and workers drastically differ in ovary size. This adult ovary phenotype difference becomes established during the final larval instar, when massive programmed cell death leads to the degeneration of 95-99% of the ovariole anlagen in workers. The higher juvenile hormone (JH) levels in queen larvae protect the ovaries against such degeneration. To gain insights into the molecular architecture underlying this divergence critical for adult caste fate and worker sterility, we performed a microarray analysis on fourth and early fifth instar queen and worker ovaries...
October 5, 2016: Insect Biochemistry and Molecular Biology
Tian Tao, Xi Xie, Mingxin Liu, Qinghua Jiang, Dongfa Zhu
The sesquiterpenoid methyl farnesoate (MF) is the unepoxidized form of insect juvenile hormone (JH) III, and is considered an equivalent of JH in crustaceans. Degradation of MF is similar to that of JH which occurs through ester hydrolysis by specific carboxylesterases (CXEs). In this study, the full-length cDNAs of two JH esterase-like CXEs were cloned from the swimming crab, Portunus trituberculatus. The predicted amino acid sequences of the two PtCXEs contain the conserved motifs including catalytic triad and oxyanion hole, which are the hallmark of the CXE family proteins...
October 5, 2016: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Marisa A Rodrigues, Thomas Flatt
In most animals reproduction trades off with somatic maintenance and survival. Physiologically this trade-off is mediated by hormones with opposite effects on reproduction and maintenance. In many insects, this regulation is achieved by an endocrine network that integrates insulin-like/IGF-1 signaling (IIS), juvenile hormone (JH), and the yolk precursor vitellogenin (Vg) (or, more generally, yolk proteins [YPs]). Downregulation of this network promotes maintenance and survival at the expense of reproduction...
August 2016: Current Opinion in Insect Science
Xiaoqing Wu, Meizi Wang, Juan Huang, Li Zhang, Zhe Zhang, Yun Ling, Xinling Yang, Stephen S Tobe
BACKGROUND: The FGLa-allatostatins (ASTs) are a family of neuropeptides that can inhibit juvenile hormone biosynthesis by the corpora allata (CA) in vitro, and therefore, they are regarded as insect growth regulator (IGR) candidates for pest control. In our previous studies, an AST mimic, H17 was found to have a significant effect on JH biosynthesis by cockroach CA, both in vitro and in vivo. To discover new potential mimics and explore the substituent effect on the inhibition of JH biosynthesis, 30 analogs, modified with various substituents on the benzene ring at the N-terminus of lead compound H17, were designed and synthesized...
September 22, 2016: Pest Management Science
Mingxin Liu, Xi Xie, Tian Tao, Qinghua Jiang, Juan Shao, Dongfa Zhu
Methoprene-tolerant (Met) belongs to the basic helix-loop-helix (bHLH)-Per-Arnt-Sim (PAS) family of nuclear transcriptional regulators, and is the leading candidate receptor for the insect Juvenile hormone (JH) and the crustacean methyl farnesoate (MF). In the present study, a full-length cDNA of Met was cloned from the swimming crab, Portunus trituberculatus (PtMet). The PtMet amino acid sequence was found to contain domains characteristic of the bHLH-PAS family proteins and to have several conserved amino acid residues specifically responsible for JH or MF binding...
September 29, 2016: Animal Reproduction Science
Edward Jd Greenwood, Nicholas J Matheson, Kim Wals, Dick Jh van den Boomen, Robin Antrobus, James C Williamson, Paul J Lehner
Viruses manipulate host factors to enhance their replication and evade cellular restriction. We used multiplex tandem mass tag (TMT)-based whole cell proteomics to perform a comprehensive time course analysis of >6,500 viral and cellular proteins during HIV infection. To enable specific functional predictions, we categorized cellular proteins regulated by HIV according to their patterns of temporal expression. We focussed on proteins depleted with similar kinetics to APOBEC3C, and found the viral accessory protein Vif to be necessary and sufficient for CUL5-dependent proteasomal degradation of all members of the B56 family of regulatory subunits of the key cellular phosphatase PP2A (PPP2R5A-E)...
September 30, 2016: ELife
Jun Mei Zhang, Clement Jh Chan, Ning Kang, Jia Lin Soon, Kenny Yk Sin, Victor Tt Chao, Teing Ee Tan, Chong Hee Lim, Mathew J Chakaramakkil, Adrian Sw Ooi, Yeow Leng Chua, Ru San Tan, Liang Zhong
No abstract text is available yet for this article.
August 2016: Annals of the Academy of Medicine, Singapore
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Journal of Vascular and Interventional Radiology: JVIR
Magdalena B Rother, Kristin Jensen, Mirjam van der Burg, Fleur S van de Bovenkamp, Roel Kroek, Wilfred F J van IJcken, Vincent H J van der Velden, Tom Cupedo, Ole K Olstad, Jacques J M van Dongen, Menno C van Zelm
Newborns are unable to mount antibody responses towards certain antigens. This has been related to the restricted repertoire of immunoglobulin (Ig) genes of their B cells. The mechanisms underlying the restricted fetal Ig gene repertoire are currently unresolved. We here addressed this with detailed molecular and cellular analysis of human precursor-B cells from fetal liver, fetal bone marrow (BM), and pediatric BM. In the absence of selection processes, fetal B-cell progenitors more frequently used proximal V, D and J genes in complete IGH gene rearrangements, despite normal Ig locus contraction...
2016: Scientific Reports
Erik J Timmermans, Suzan van der Pas, Elaine M Dennison, Stefania Maggi, Richard Peter, Maria Victoria Castell, Nancy L Pedersen, Michael D Denkinger, Mark H Edwards, Federica Limongi, Florian Herbolsheimer, Mercedes Sánchez-Martínez, Paola Siviero, Rocio Queipo, Laura A Schaap, Dorly Jh Deeg
BACKGROUND: Older adults with osteoarthritis (OA) often report that their disease symptoms are exacerbated by weather conditions. This study examines the association between outdoor physical activity (PA) and weather conditions in older adults from six European countries and assesses whether outdoor PA and weather conditions are more strongly associated in older persons with OA than in those without the condition. METHODS: The American College of Rheumatology classification criteria were used to diagnose OA...
August 24, 2016: Journal of Physical Activity & Health
Wei Li, Tingcai Cheng, Wenbo Hu, Zhangchuan Peng, Chun Liu, Qingyou Xia
Juvenile hormone (JH) regulates the insect growth and development. JH appears in the hemolymph bound by a specific glycoprotein, juvenile hormone-binding protein (JHBP), which serves as a carrier to release the hormone to target tissues and cells. However, JHBP family candidates, expression patterns, and functional implications are still unclear. In this study, we identified 41 genes-containing conserved JHBP domains distributed across eight chromosomes of the silkworm Bombyx mori. A phylogenetic tree showed that the silkworm JHBP (BmJHBP) genes could be classified into two major branches and four subfamilies...
September 8, 2016: Molecular Genetics and Genomics: MGG
Hai-Jun Xiao, Xiao-Wei Fu, Yong-Qiang Liu, Kong-Ming Wu
Annual migration of pests between different seasonal habitats can lead to serious crop damage. Reproductive immaturity is generally associated with the migratory process (oogenesis-flight syndrome), but the mechanism of reproductive development during migration varies unpredictably. Here, the vitellogenin gene (MsVg) and three key regulatory enzyme genes (MsJhamt, MsJheh and MsJhe) related to juvenile hormone (JH) synthesis and degradation were identified and characterized in Mythimna separata. The relative expression of MsVg varied significantly in response to seasonal changes and was significantly correlated with stages of ovarian development...
2016: Scientific Reports
Angelien Sieben, Hein Aw van Onzenoort, Kees J van Laarhoven, Sebastian Jh Bredie
BACKGROUND: Poor adherence to medication is one of the limitations in the treatment of cardiovascular diseases, thereby increasing the risk of premature death, hospital admissions, and related costs. There is a need for simple and easy-to-implement interventions that are based on patients' perspectives, beliefs, and perceptions of their illness and medication. OBJECTIVE: The objective is to test the effectivity of this intervention to improve medication adherence in patients with established cardiovascular disease, that is, in secondary prevention...
2016: JMIR Research Protocols
Pragya Yadav, Matthew T Carr, Ruby Yu, Alice Mumbey-Wafula, Linda A Spatz
INTRODUCTION: The Epstein Barr Virus (EBV) has been associated with the autoimmune disease, Systemic Lupus Erythematosus (SLE). EBV nuclear antigen-I (EBNA-1) is the major nuclear protein of EBV. We previously generated an IgG monoclonal antibody (MAb) to EBNA-1, 3D4, and demonstrated that it cross-reacts with double stranded DNA (dsDNA) and binds the 148 amino acid viral binding site (VBS) in the carboxyl region of EBNA-1. The aim of the present study was to characterize another antibody to EBNA-1 that cross-reacts with dsDNA, compare its immunoglobulin genes to 3D4, and finely map the epitope in EBNA-1 that is recognized by these cross-reactive antibodies...
September 2016: Immunity, Inflammation and Disease
T Pamminger, A Buttstedt, V Norman, A Schierhorn, C Botías, J C Jones, K Basley, W O H Hughes
Reproduction has been shown to be costly for survival in a wide diversity of taxa. The resulting trade-off, termed the reproduction-survival trade-off, is thought to be one of the most fundamental forces of life-history evolution. In insects the pleiotropic effect of juvenile hormone (JH), antagonistically regulating reproduction and pathogen resistance, is suggested to underlie this phenomenon. In contrast to the majority of insects, reproductive individuals in many eusocial insects defy this trade-off and live both long and prosper...
September 7, 2016: Journal of Insect Physiology
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