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https://www.readbyqxmd.com/read/28645197/pht%C3%AE-promoted-mobilization-of-non-conjugative-resistance-plasmids-from-enterococcus-faecium-to-enterococcus-faecalis
#1
Laura Di Sante, Gianluca Morroni, Andrea Brenciani, Carla Vignaroli, Alberto Antonelli, Marco Maria D'Andrea, Andrea Di Cesare, Eleonora Giovanetti, Pietro E Varaldo, Gian Maria Rossolini, Francesca Biavasco
Objectives: : To analyse the recombination events associated with conjugal mobilization of two multiresistance plasmids, pRUM 17i48 and pLAG (formerly named pDO1-like), from Enterococcus faecium 17i48 to Enterococcus faecalis JH2-2. Methods: : The plasmids from two E. faecalis transconjugants (JH-4T, tetracycline resistant, and JH-8E, erythromycin resistant) and from the E. faecium donor (also carrying a pHTβ-like conjugative plasmid, named pHTβ 17i48 ) were investigated by several methods, including PCR mapping and sequencing, S1-PFGE followed by Southern blotting and hybridization, and WGS...
June 22, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28639284/soft-tissue-angiofibroma-clinicopathologic-immunohistochemical-and-molecular-analysis-of-14-cases
#2
Elise M Bekers, Patricia Jta Groenen, Marian Aj Verdijk, Winny L Raaijmakers-van Geloof, Paul Roepman, Robert Vink, Nathalie D B Gilhuijs, Joost M van Gorp, Judith Vmg Bovée, David H Creytens, Adrienne M Flanagan, Albert Jh Suurmeijer, Thomas Mentzel, Elsa Arbajian, Uta Flucke
Soft tissue angiofibroma is rare and has characteristic histomorphological and genetic features. For diagnostic purposes, there are no specific antibodies available. Fourteen lesions (6 females, 8 males; age range 7 - 67 years) of the lower extremities (12) and trunk (2) were investigated by immunohistochemistry, including for the first time NCOA2. NCOA2 was also tested in a control group of other spindle cell lesions. The known fusion-genes (AHRR-NCOA2 and GTF2I-NCOA2) were examined using RT-PCR in order to evaluate their diagnostic value...
June 22, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28637722/cross-sectional-surveillance-study-to-phenotype-lorry-drivers-sedentary-behaviours-physical-activity-and-cardio-metabolic-health
#3
Veronica Varela-Mato, Orlagh O'Shea, James A King, Thomas Yates, David J Stensel, Stuart Jh Biddle, Myra A Nimmo, Stacy A Clemes
OBJECTIVES: Elevated risk factors for a number of chronic diseases have been identified in lorry drivers. Unhealthy lifestyle behaviours such as a lack of physical activity (PA) and high levels of sedentary behaviour (sitting) likely contribute to this elevated risk. This study behaviourally phenotyped UK lorry drivers' sedentary and non-sedentary behaviours during workdays and non-workdays and examined markers of drivers cardio-metabolic health. SETTING: A transport company from the East Midlands, UK...
June 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28623148/male-sexual-enhancement-after-methoprene-treatment-in-anastrepha-fraterculus-diptera-tephritidae-a-sustained-response-that-does-not-fade-away-after-sexual-maturation
#4
G E Bachmann, F Devescovi, A L Nussenbaum, J L Cladera, P C Fernández, M T Vera, P E A Teal, D F Segura
The juvenile hormone (JH) of insects triggers physiological changes related to reproduction in adults of both sexes. Methoprene is a sesquiterpene with some effects that are analogous to those of JH. Treatments with methoprene accelerate sexual maturation in males of the South American fruit fly Anastrepha fraterculus, giving young males a mating advantage over non-treated males of the same age. Here, we evaluated the effects of methoprene treatment on A. fraterculus males after the sexual maturation phase and tested whether this compound provides a long-term mating advantage...
June 13, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28590159/which-patients-die-in-their-preferred-place-a-secondary-analysis-of-questionnaire-data-from-bereaved-relatives
#5
Natasja Jh Raijmakers, Anke Je de Veer, Rosanne Zwaan, Jolien M Hofstede, Anneke L Francke
BACKGROUND: Previous studies on factors influencing the place of death have focused on cancer patients dying at home. However, home is not always the preferred place. AIM: To provide insight into the extent to which patients with various diseases die in their preferred place and into factors associated with dying in the preferred place. DESIGN: A secondary analysis of the data set of the evaluation study of the National Quality Improvement Programme for Palliative Care was undertaken to explore factors related to 'dying in the preferred place'...
June 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28583672/monascus-ruber-as-cell-factory-for-lactic-acid-production-at-low-ph
#6
Ruud A Weusthuis, Astrid E Mars, Jan Springer, Emil Jh Wolbert, Hetty van der Wal, Truus G de Vrije, Mark Levisson, Audrey Leprince, G Bwee Houweling-Tan, Antoine Pha Moers, Sjon Na Hendriks, Odette Mendes, Yvonne Griekspoor, Marc Wt Werten, Peter J Schaap, John van der Oost, Gerrit Eggink
A Monascus ruber strain was isolated that was able to grow on mineral medium at high sugar concentrations and 175g/l lactic acid at pH 2.8. Its genome and transcriptomes were sequenced and annotated. Genes encoding lactate dehydrogenase (LDH) were introduced to accomplish lactic acid production and two genes encoding pyruvate decarboxylase (PDC) were knocked out to subdue ethanol formation. The strain preferred lactic acid to glucose as carbon source, which hampered glucose consumption and therefore also lactic acid production...
June 3, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28580854/changes-in-lower-limb-muscle-function-and-muscle-mass-following-exercise-based-interventions-in-patients-with-chronic-obstructive-pulmonary-disease-a-review-of-the-english-language-literature
#7
Jana De Brandt, Martijn A Spruit, Dominique Hansen, Frits Me Franssen, Wim Derave, Maurice Jh Sillen, Chris Burtin
Chronic obstructive pulmonary disease (COPD) patients often experience lower limb muscle dysfunction and wasting. Exercise-based training has potential to improve muscle function and mass, but literature on this topic is extensive and heterogeneous including numerous interventions and outcome measures. This review uses a detailed systematic approach to investigate the effect of this wide range of exercise-based interventions on muscle function and mass. PUBMED and PEDro databases were searched. In all, 70 studies ( n = 2504 COPD patients) that implemented an exercise-based intervention and reported muscle strength, endurance, or mass in clinically stable COPD patients were critically appraised...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28569188/clustering-and-correlates-of-screen-time-and-eating-behaviours-among-young-adolescents
#8
Natalie Pearson, Paula Griffiths, Stuart Jh Biddle, Julie P Johnston, Sonia McGeorge, Emma Haycraft
BACKGROUND: Screen-time and eating behaviours are associated in adolescents, but few studies have examined the clustering of these health behaviours in this age group. The identification of clustered health behaviours, and influences on adolescents' clustered health behaviours, at the time when they are most likely to become habitual, is important for intervention design. The purpose of this study was to assess the prevalence and clustering of health behaviours in adolescents, and examine the sociodemographic, individual, behavioural, and home social and physical environmental correlates of clustered health behaviours...
May 31, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28554733/the-role-of-insulin-signalling-in-the-endocrine-stress-response-in-drosophila-melanogaster-a-mini-review
#9
REVIEW
N E Gruntenko, I Yu Rauschenbach
The endocrine stress response in Drosophila includes catecholamines, juvenile hormone (JH), 20-hydroxyecdysone (20E) and the insulin/insulin-like growth factor signalling pathway (IIS). Several changes in the IIS and hormonal status that occur under unfavourable conditions are universal and do not depend on the nature of stress exposure. The reviewed studies on the impact of different element of the Drosophila IIS, such as insulin-like receptor, the homologue of its substrate, CHICO, the transcription factor dFOXO and insulin like peptide 6, on the hormonal status suggest that the IIS controls catecholamine metabolism indirectly via JH, and there is a feedback loop in the interaction of JH and IIS...
May 26, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28539140/hemoglobin-oxygen-saturation-with-mild-hypoxia-and-microgravity
#10
Johnny Conkin, James H Wessel, Jason R Norcross, Omar S Bekdash, Andrew F J Abercromby, Matthew D Koslovsky, Michael L Gernhardt
INTRODUCTION: Microgravity (μG) exposure and even early recovery from μG in combination with mild hypoxia may increase the alveolar-arterial oxygen (O2) partial pressure gradient. METHODS: Four male astronauts on STS-69 (1995) and four on STS-72 (1996) were exposed on Earth to an acute sequential hypoxic challenge by breathing for 4 min 18.0%, 14.9%, 13.5%, 12.9%, and 12.2% oxygen-balance nitrogen. The 18.0% O2 mixture at sea level resulted in an inspired O2 partial pressure (PIo2) of 127 mmHg...
June 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28536442/characterization-of-juvenile-hormone-related-genes-regulating-cantharidin-biosynthesis-in-epicauta-chinensis
#11
Ming Jiang, Shumin Lü, Yalin Zhang
Cantharidin is a defensive toxin biosynthesized by blister beetles. It is well known for medical applications and toxicity. However, the biosynthesis process of cantharidin is still not well understood. In the present study, three genes (methyl farnesoate epoxidase (EcMFE), juvenile hormone acid O-methyltransferase (EcJHAMT) and juvenile hormone epoxide hydrolase (EcJHEH)) were identified from Epicauta chinensis. The temporal and spatial expression patterns of these three genes revealed that the expression levels of EcMFE and EcJHEH were high in the first instar larval stage of E...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28522854/genetic-tools-to-study-juvenile-hormone-action-in-drosophila
#12
A A Baumann, M J Texada, H M Chen, J N Etheredge, D L Miller, S Picard, R Warner, J W Truman, L M Riddiford
The insect juvenile hormone receptor is a basic helix-loop-helix (bHLH), Per-Arnt-Sim (PAS) domain protein, a novel type of hormone receptor. In higher flies like Drosophila, the ancestral receptor germ cell-expressed (gce) gene has duplicated to yield the paralog Methoprene-tolerant (Met). These paralogous receptors share redundant function during development but play unique roles in adults. Some aspects of JH function apparently require one receptor or the other. To provide a foundation for studying JH receptor function, we have recapitulated endogenous JH receptor expression with single cell resolution...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28522416/implantation-assays-using-the-integument-of-early-stage-bombyx-larvae-insights-into-the-mechanisms-underlying-the-acquisition-of-competence-for-metamorphosis
#13
Tomohiro Inui, Takaaki Daimon
It is widely accepted that the anti-metamorphic action of insect juvenile hormones (JHs) is required to inhibit larval-pupal metamorphosis. However, recent studies using RNAi or knockout techniques reveal that larval status may be maintained independently of JHs during the early larval stages. To investigate why larvae of very early instars do not have competence to metamorphose and how they acquire this competence through larval development, we revisited the classic experiments of Piepho (ca. 1930s) and performed implantation assays using the integument of very young larvae of the silkworm, Bombyx mori...
May 15, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28518004/middle-ear-barotrauma-in-student-pilots
#14
Jung Heob Sohn, Kyoung Rai Cho
INTRODUCTION: The present study reports the clinical features of middle ear barotrauma in student pilots in the Republic of Korea Air Force. METHODS: The authors reviewed medical records of student pilots with barotrauma. The grade of barotrauma was assigned using Teed's classification. This study included nasal symptoms, endoscopic findings of the nasal cavity, and clinical course (duration, recurrence). The relationship between middle ear barotrauma and the nasal airway was also evaluated...
April 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28517999/venous-gas-emboli-and-ambulation-at-4-3-psia
#15
Johnny Conkin, Neal W Pollock, Michael J Natoli, Stefanie D Martina, James H Wessel, Michael L Gernhardt
INTRODUCTION: Ambulation during extravehicular activity on Mars may increase the risk of decompression sickness through enhanced bubble formation in the lower body. HYPOTHESES: walking effort (ambulation) before an exercise-enhanced denitrogenation (prebreathe) protocol at 14.7 psia does not increase the incidence of venous gas emboli (VGE) at 4.3 psia, but does increase incidence if performed after tissues become supersaturated with nitrogen at 4.3 psia. METHODS: VGE results from 45 control subjects who performed exercise prebreathe without ambulation before or during a 4-h exposure to 4...
April 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28513277/effect-of-gastrocnemius-kinesio-taping-on-countermovement-jump-performance-and-vertical-stiffness-following-muscle-fatigue
#16
Sahar Boozari, Mohammad Ali Sanjari, Ali Amiri, Ismail Ebrahimi Takamjani
CONTEXT: Kinesio Tape (KT) is a widely used intervention in the fields of sports and rehabilitation. However, its effects on lower extremity behavior during functional activities are not entirely known. OBJECTIVE: To test the hypothesis that application of KT can change performance and vertical stiffness during the countermovement jump (CMJ) before and after a fatigue protocol. DESIGN: A pre and post design to study the effect of KT in two situations, pre- and post-fatigue...
May 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28510511/corrigendum
#17
(no author information available yet)
Birkeland AC, Owen JH, Prince ME. 2015. Targeting head and neck cancer stem cells: current advances and future challenges. J Dent Res. 94(11):1516-1523. (Original DOI: 10.1177/0022034515601960 ) In this article, the funding source was not declared. The Acknowledgments have been updated in the online article as follows: Andrew Birkeland is a Research Fellow funded on a T32 Advanced Research Training in Otolaryngology Program Training Grant (T32 DC005356) funded by the National Institutes of Health NIDCD (National Institute On Deafness And Other Communication Disorders)...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28502113/epigenetic-modifications-of-the-vh-region-after-djh-recombination-in-pro-b-cells
#18
Yanying Dong, Caijun Wu, Xiaohui Zhao, Ping Zhang, Hua Zhang, Mingzhe Zheng, Shichang Li, Junna Jiao, Xiaozhuo Yu, Zhuangwei Lv, Yanhong Ji
The variable region of murine immunoglobulin heavy chain (Igh) is assembled by sequential DH -JH and VH -DJH recombination. The accessibility of Igh locus determines the order of rearrangement. Because of the large number of VH genes and lack of a suitable model, the epigenetic modifications of VH genes after DJH recombination have not previously been characterized. Here, we employed two v-Abl pro-B cell lines, in which Igh locus is in germline and DJH -recombined configuration, respectively. The DJH junction displays the characteristics of recombination center, such as high levels of activation-associated histone modifications and recombination activating gene protein (RAG) binding in DJH -rearranged pro-B cells, which extend the recombination center model proposed for germline Igh locus...
May 14, 2017: Immunology
https://www.readbyqxmd.com/read/28490760/hormonal-pleiotropy-helps-maintain-queen-signal-honesty-in-a-highly-eusocial-wasp
#19
Ricardo Caliari Oliveira, Ayrton Vollet-Neto, Cintia Akemi Oi, Jelle S van Zweden, Fabio Nascimento, Colin Sullivan Brent, Tom Wenseleers
In insect societies, both queens and workers produce chemicals that reliably signal caste membership and reproductive status. The mechanisms that help to maintain the honesty of such queen and fertility signals, however, remain poorly studied. Here we test if queen signal honesty could be based on the shared endocrine control of queen fertility and the production of specific signals. In support of this "hormonal pleiotropy" hypothesis, we find that in the common wasp, application of methoprene (a juveline hormone analogue) caused workers to acquire a queen-like cuticular hydrocarbon profile, resulting in the overproduction of known queen pheromones as well as some compounds typically linked to worker fertility...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28490635/the-foxo-transcription-factor-controls-insect-growth-and-development-by-regulating-juvenile-hormone-degradation-in-the-silkworm-bombyx-mori
#20
Baosheng Zeng, Yuping Huang, Jun Xu, Takahiro Shiotsuki, Hua Bai, Subba Reddy Palli, Yongping Huang, Anjiang Tan
Forkhead box O (FOXO) functions as the terminal transcription factor of the insulin signaling pathway and regulates multiple physiological processes in many organisms, including lifespan in insects. However, how FOXO interacts with hormone signaling to modulate insect growth and development is largely unknown. Here, using the transgene-based CRISPR/Cas9 system, we generated and characterized mutants of the silkworm Bombyx mori FOXO (BmFOXO) to elucidate its physiological functions during development of this lepidopteran insect...
May 10, 2017: Journal of Biological Chemistry
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