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https://www.readbyqxmd.com/read/29417365/integrating-obstetrical-care-and-wic-nutritional-services-to-address-maternal-obesity-and-postpartum-weight-retention
#1
Susan M Gross, Marycatherine Augustyn, Janice L Henderson, Khrysta Baig, Christie A Williams, Bolanle Ajao, Patricia Bell-Waddy, David M Paige
OBJECTIVE: This pilot study evaluated a cost neutral, integrated Special Supplemental Nutrition Program for Women Infants and Children (WIC) and obstetrical service model designed to prevent postpartum weight retention in obese women. METHODS: A sample of women who received benefits from the Johns Hopkins (JH) WIC program and prenatal care from the JH Nutrition in Pregnancy Clinic, which provides obstetrical care for women with a BMI ≥ 30 kg/m2, participated in the WICNIP randomized clinical trial...
February 7, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29417057/fat-storage-inducing-transmembrane-fit-or-fitm-proteins-are-related-to-lipid-phosphatase-phosphotransferase-enzymes
#2
Matthew Hayes, Vineet Choudhary, Namrata Ojha, John Jh Shin, Gil-Soo Han, George M Carman, Christopher Jr Loewen, William A Prinz, Timothy Levine
Fat storage-inducing transmembrane (FIT or FITM) proteins have been implicated in the partitioning of triacylglycerol to lipid droplets and the budding of lipid droplets from the ER. At the molecular level, the sole relevant interaction is that FITMs directly bind to triacyglycerol and diacylglycerol, but how they function at the molecular level is not known. Saccharomyces cerevisiae has two FITM homologues: Scs3p and Yft2p. Scs3p was initially identified because deletion leads to inositol auxotrophy, with an unusual sensitivity to addition of choline...
December 28, 2017: Microbial Cell
https://www.readbyqxmd.com/read/29381091/development-of-an-interprofessional-competency-framework-for-collaborative-practice-in-japan
#3
Junji Haruta, Kazue Yoshida, Michiko Goto, Hisashi Yoshimoto, Shuhei Ichikawa, Youhei Mori, Kenji Yoshimi, Mariko Otsuka
Rapid aging of the population necessitates improved collaboration among healthcare professionals. Unfortunately, interprofessional collaboration has yet to be implemented effectively in Japan. Therefore, we aimed to develop an interprofessional competency framework for Japanese healthcare professionals. The project was conducted as a four-step process, starting with initial categorization of potential competency domains,, followed by guiding principle and prototype development, feedback on the prototype, and final consensus...
January 30, 2018: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29369215/association-between-daily-life-experience-and-psychological-well-being-in-people-living-with-nonpsychotic-mental-disorders-protocol-for-a-systematic-review-and-meta-analysis
#4
REVIEW
Jeffery Ho, Shirley P C Ngai, William K K Wu, Wai Kai Hou
BACKGROUND: Evidence has shown that people living with nonpsychotic mental disorders experience difficulties in maintaining their daily living, consequently impacting on psychological well-being. However, the role of daily life experience remains unclear. This systematic review and meta-analysis aims to determine the association between daily life experience and psychological well-being in people living with nonpsychotic mental disorders, and evaluate daily life experience as a moderator of psychological well-being in this population...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29362416/creb-binding-protein-plays-key-roles-in-juvenile-hormone-action-in-the-red-flour-beetle-tribolium-castaneum
#5
Jingjing Xu, Amit Roy, Subba Reddy Palli
Juvenile hormones (JH) and ecdysteroids regulate many biological and metabolic processes. CREB-binding protein (CBP) is a transcriptional co-regulator with histone acetyltransferase (HAT) activity. Therefore, CBP is involved in activation of many transcription factors that regulate expression of genes associated with postembryonic development in insects. However, the function of CBP in JH action in insects is not well understood. Hence, we studied the role of CBP in JH action in the red flour beetle, Tribolium castaneum and the Tribolium cell line...
January 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29361282/a-rapid-quantitative-assay-for-juvenile-hormones-and-intermediates-in-the-biosynthetic-pathway-using-gas-chromatography-tandem-mass-spectrometry
#6
Zhen-Peng Kai, Yue Yin, Zhi-Ruo Zhang, Juan Huang, Stephen S Tobe, Shan-Shan Chen
A method for rapid quantitation of insect juvenile hormones (JH) and intermediates in the biosynthetic pathway, both in vitro and in vivo (hemolymph and whole body), has been developed using GC-MS/MS. This method is as simple as the radiochemical assay (RCA), the most commonly used method for measurement of JH biosynthesis in vitro, without need for further purification and derivatization, or radioactive precursors or ligands. It shows high sensitivity, accuracy and reproducibility. Linear responses were obtained the range of 1-800 ng/mL (approximately 4-3000 nM)...
January 17, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29358507/gene-delivery-of-medium-chain-acyl-coenzyme-a-dehydrogenase-mcad-induces-physiological-cardiac-hypertrophy-and-protects-against-pathological-remodelling
#7
Bianca C Bernardo, Kate L Weeks, Thawin Pongsukwechkul, Xiaoming Gao, Helen Kiriazis, Nelly Cemerlang, Esther Jh Boey, Yow Keat Tham, Chad J Johnson, Hongwei Qian, Xiao-Jun Du, Paul Gregorevic, Julie R McMullen
We previously showed that medium chain acyl-coenzyme A dehydrogenase (MCAD, key regulator of fatty acid oxidation) is positively modulated in the heart by the cardioprotective kinase, phosphoinositide 3-kinase [PI3K(p110α)]. Disturbances in cardiac metabolism are a feature of heart failure patients, and targeting metabolic defects is considered a potential therapeutic approach. The specific role of MCAD in the adult heart is unknown. To examine the role of MCAD in the heart and to assess the therapeutic potential of increasing MCAD in the failing heart, we developed a gene therapy tool using recombinant adeno-associated viral vectors (rAAV) encoding MCAD...
January 22, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29355708/juvenile-hormone-and-sesquiterpenoids-in-arthropods-biosynthesis-signaling-and-role-of-microrna
#8
REVIEW
Zhe Qu, William G Bendena, Stephen S Tobe, Jerome H L Hui
Arthropod molting and reproduction are precisely controlled by the levels of sesquiterpenoids, a class of C15 hormones derived from three isoprene units. The two major functional arthropod sesquiterpenoids are juvenile hormone (JH) and methyl farnesoate (MF). In hemimetabolous insects (such as the aphids, bugs, and cockroaches) and holometabolous insects (such as beetles, bees, butterflies, and flies), dramatic decrease in the titers of JH and/or MF promote metamorphosis from larvae to adults either directly or through an intermediate pupal stage, respectively...
January 17, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29351166/the-neuromuscular-biochemical-endocrine-and-mood-responses-to-small-sided-games-training-in-professional-soccer
#9
Sparkes W, Turner An, Weston M, Russell M, Johnston Mj, Kilduff Lp
The 24h responses to small-sided games (SSG) soccer training were characterized. Professional soccer players (n=16) performed SSG's (4vs4 + goalkeepers; 6x7-min, 2-min inter-set recovery) with performance (peak-power output, PPO; jump height, JH), physiological (blood creatine kinase: CK, lactate; salivary testosterone, cortisol), and mood measures collected before (baseline), and after (immediately; 0h, +2h, +24h). For PPO and JH, possibly small-moderate reductions occurred at 0h (-1.1W·kg; ±0.9W·kg, -3...
January 17, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29315477/enrichment-of-high-affinity-subclasses-and-glycoforms-from-serum-derived-igg-using-fc%C3%AE-rs-as-affinity-ligands
#10
Boesch Aw, Kappel Jh, Mahan Ae, Chu Th, Crowley Ar, Osei-Owusu Ny, Alter G, Ackerman Me
As antibodies continue to gain predominance in drug discovery and development pipelines, efforts to control and optimize their activity in vivo have matured to incorporate sophisticated abilities to manipulate engagement of specific Fc binding partners. Such efforts to promote diverse functional outcomes include modulating IgG-Fc affinity for FcγRs to alternatively potentiate or reduce effector functions, such as antibody-dependent cellular cytotoxicity and phagocytosis. While a number of natural and engineered Fc features capable of eliciting variable effector functions have been demonstrated in vitro and in vivo, elucidation of these important functional relationships has taken significant effort through use of diverse genetic, cellular and enzymatic techniques...
January 8, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29314423/kr%C3%A3-ppel-homologue-1-acts-as-a-repressor-and-an-activator-in-the-transcriptional-response-to-juvenile-hormone-in-adult-mosquitoes
#11
R Ojani, X Fu, T Ahmed, P Liu, J Zhu
Krüppel homologue 1 (Kr-h1) is a zinc finger transcription factor that is upregulated in insects by juvenile hormone (JH) in metamorphosis and adult reproduction. The molecular function of Kr-h1 in reproduction remains largely unknown. Here we report that AaKr-h1 functions as an important transcription regulator in adult female Aedes aegypti mosquitoes. The amount of AaKr-h1 protein increases with rising JH levels after adult emergence, reaches its peak at 48 h after eclosion, then decreases gradually and disappears after blood feeding...
January 4, 2018: Insect Molecular Biology
https://www.readbyqxmd.com/read/29284404/multiple-functions-of-creb-binding-protein-during-postembryonic-development-identification-of-target-genes
#12
Amit Roy, Smitha George, Subba Reddy Palli
BACKGROUND: Juvenile hormones (JH) and ecdysteroids control postembryonic development in insects. They serve as valuable targets for pest management. Hence, understanding the molecular mechanisms of their action is of crucial importance. CREB-binding protein (CBP) is a universal transcriptional co-regulator. It controls the expression of several genes including those from hormone signaling pathways through co-activation of many transcription factors. However, the role of CBP during postembryonic development in insects is not well understood...
December 29, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29248737/environmental-and-hormonal-control-of-body-color-polyphenism-in%C3%A2-late-instar-desert-locust-nymphs-role-of-the-yellow-protein
#13
Ryohei Sugahara, Seiji Tanaka
Locusts show body color polyphenism that is considered to be an adaptation to various biotic and abiotic environmental changes. In Schistocerca gregaria, wild-type late-instar nymphs growing under crowded conditions (gregarious form) develop yellow and black body coloration, whereas they assume various body colors under isolated conditions (solitarious form). Black and green body colorations are induced by the neuropeptide corazonin (Crz) and juvenile hormone (JH), respectively. To characterize the molecular mechanisms controlling body color polyphenism, we investigated factors influencing body coloration in S...
December 14, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29237851/micrornas-regulate-the-sesquiterpenoid-hormonal-pathway-in-drosophila-and-other-arthropods
#14
Zhe Qu, William G Bendena, Wenyan Nong, Kenneth W Siggens, Fernando G Noriega, Zhen-Peng Kai, Yang-Yang Zang, Alex C Koon, Ho Yin Edwin Chan, Ting Fung Chan, Ka Hou Chu, Hon Ming Lam, Michael Akam, Stephen S Tobe, Jerome Ho Lam Hui
Arthropods comprise the majority of all described animal species, and understanding their evolution is a central question in biology. Their developmental processes are under the precise control of distinct hormonal regulators, including the sesquiterpenoids juvenile hormone (JH) and methyl farnesoate. The control of the synthesis and mode of action of these hormones played important roles in the evolution of arthropods and their adaptation to diverse habitats. However, the precise roles of non-coding RNAs, such as microRNAs (miRNAs), controlling arthropod hormonal pathways are unknown...
December 20, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29219212/host-mirnas-are-involved-in-hormonal-regulation-of-hasnpv-triggered-climbing-behavior-in-helicoverpa-armigera
#15
Songdou Zhang, Shiheng An, Kelli Hoover, Zhen Li, Xiangrui Li, Xiaoming Liu, Zhongjian Shen, Haibo Fang, Vera I D Ros, Qingwen Zhang, Xiaoxia Liu
Baculoviruses manipulate host climbing behavior to ensure that the hosts die at elevated positions on host plants to facilitate virus proliferation and transmission, which is a process referred to as tree-top disease. However, the detailed molecular mechanism underlying tree-top disease has not been elucidated. Using transcriptome analysis we showed that two hormone signals, juvenile hormone (JH) and 20-hydroxyecdysone (20E), are key components involved in HaSNPV-induced tree-top disease in Helicoverpa armigera larvae...
December 8, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29208225/pheromone-biosynthesis-in-bark-beetles
#16
REVIEW
Claus Tittiger, Gary J Blomquist
Pine bark beetles rely on aggregation pheromones to coordinate mass attacks and thus reproduce in host trees. The structural similarity between many pheromone components and those of defensive tree resin led to early suggestions that pheromone components are metabolic derivatives of ingested precursors. This model has given way to our current understanding that most pheromone components are synthesized de novo. Their synthesis involves enzymes that modify products from endogenous metabolic pathways; some of these enzymes have been identified and characterized...
December 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/29198453/effects-of-rotigotine-on-clinical-symptoms-quality-of-life-and-sleep-hygiene-adequacy-in-haemodialysis-associated-restless-legs-syndrome
#17
Vicent Esteve, Jose Carneiro, Gabriel Salazar, Mónica Pou, Irati Tapia, Miquel Fulquet, Verónica Duarte, Anna Saurina, Fátima Moreno, Manel Ramírez de Arellano
BACKGROUND: Restless legs syndrome (RLS) is a neurological disorder characterised by bothersome symptoms associated with impaired quality of life and sleep hygiene. Rotigotine is a novel therapeutic alternative, although few studies have been published in patients on haemodialysis (HD) with RLS treated with rotigotine. OBJECTIVES: 1.- To establish the prevalence of RLS in our HD unit. 2.- To evaluate the efficacy and safety profile of rotigotine and its effect on symptoms, quality of life and sleep hygiene in our HD population with RLS...
November 30, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29197826/effects-of-host-cell-sterol-composition-upon-internalization-of-yersinia-pseudotuberculosis-and-clustered-beta-1-integrin
#18
JiHyun Kim, Hana S Fukuto, Deborah A Brown, James B Bliska, Erwin London
Yersinia pseudotuberculosis is a foodborne pathogenic bacterium that causes acute gastrointestinal illness, but its mechanisms of infection are incompletely described. We examined how host cell sterol composition affected Y. pseudotuberculosis uptake. To do this, we depleted or substituted cholesterol in human MDA-MB-231 epithelial cells with various alternative sterols. Decreasing host cell cholesterol significantly reduced pathogen internalization. When host cell cholesterol was substituted with various sterols, only desmosterol and 7-dehydrocholesterol supported internalization...
December 2, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29193439/jackhammer-esophagus-assessing-the-balance-between-prepeak-and-postpeak-contractile-integral
#19
Y Xiao, D A Carlson, Z Lin, N Alhalel, J E Pandolfino
BACKGROUND: We hypothesized that symptoms in Jackhammer esophagus (JH) are associated with an imbalance between the prepeak and postpeak phases of contraction. Thus, we developed a method to distinguish the contractile integral components of prepeak and postpeak phase contractile activity to determine the contribution of each phase and their association with dysphagia. METHODS: Patients diagnosed with JH were enrolled and compared to controls. The first five intact swallows during manometry were analyzed...
November 29, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29192423/bisphosphonates-for-paget-s-disease-of-bone-in-adults
#20
REVIEW
Luis Corral-Gudino, Adrian Jh Tan, Javier Del Pino-Montes, Stuart H Ralston
BACKGROUND: Bisphosphonates are considered to be the treatment of choice for people with Paget's disease of bone. However, the effects of bisphosphonates on patient-centred outcomes have not been extensively studied. There are insufficient data to determine whether reducing and maintaining biochemical markers of bone turnover to within the normal range improves quality of life and reduces the risk of complications. OBJECTIVES: To assess the benefits and harms of bisphosphonates for adult patients with Paget's disease of bone...
December 1, 2017: Cochrane Database of Systematic Reviews
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