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https://www.readbyqxmd.com/read/29904614/treatment-of-arrow-wounds-a-review
#1
REVIEW
Rafik Shereen, Rod J Oskouian, Marios Loukas, R Shane Tubbs
The arrow is one of the oldest weapons invented that has ties back to ancient civilization. With the advancement of modern weaponry, literature concerning the management of this traumatic wound has dwindled.  However, there are older written accounts that have led to our understanding of how we manage injuries inflicted by the arrow. One of the more comprehensive accounts was produced in the 19th century by a United States (US) Lieutenant Colonel named JH Bill. Recent cases in forensic pathology, as well as instances of trauma concerning arrowhead injuries, have documented a lack of comprehensive literature for the management of such injuries...
April 13, 2018: Curēus
https://www.readbyqxmd.com/read/29898964/early-generated-b-1-derived-b-cells-have-the-capacity-to-progress-to-become-mantle-cell-lymphoma-like-neoplasia-in-aged-mice
#2
Kyoko Hayakawa, Anthony M Formica, Yuka Nakao, Daiju Ichikawa, Susan A Shinton, Joni Brill-Dashoff, Mitchell R Smith, Herbert C Morse, Richard R Hardy
In mice, fetal/neonatal B-1 cell development generates murine CD5+ B cells (B1a) with autoreactivity. We analyzed B1a cells at the neonatal stage in a VH 11/D/JH knock-in mouse line (VH 11t) that generates an autoreactive antiphosphatidylcholine BCR. Our study revealed that antiphosphatidylcholine B1a cells develop in liver, mature in spleen, and distribute in intestine/colon, mesenteric lymph node (mLN), and body cavity as the outcome of B-1 cell development before B-2 cell development. Throughout life, self-renewing B-1 B1a cells circulate through intestine, mesenteric vessel, and blood...
June 13, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29894238/leg-swelling-an-important-differential-to-consider
#3
Muhammad Jh Rahmani, Laurenda Obeng, Shobayo Sholotan
No abstract text is available yet for this article.
June 2, 2018: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29889831/genetic-dissection-of-stress-induced-reproductive-arrest-in-drosophila-melanogaster-females
#4
Noriyuki Ojima, Yusuke Hara, Hiroki Ito, Daisuke Yamamoto
By genetic manipulations, we study the roles played by insulin-producing cells (IPCs) in the brain and their target, the corpora allata (CA), for reproductive dormancy in female Drosophila melanogaster, which is induced by exposing them to a combination of low temperature (11°C), short-day photoperiod (10L:14D) and starvation (water only) for 7 days immediately after eclosion (dormancy-inducing conditions). Artificial inactivation of IPCs promotes, whereas artificial activation impedes, the induction of reproductive dormancy...
June 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29888456/juvenile-hormone-signaling-a-mini-review
#5
REVIEW
Kang Li, Qiang-Qiang Jia, Sheng Li
Since it was first postulated by Wigglesworth in 1934, juvenile hormone (JH) is considered a status-quo hormone in insects because it prevents metamorphosis that is initiated by the molting hormone (20-hydroxyecdysone, 20E). During the last decade, significant advances have been made regarding JH signaling. First, the bHLH-PAS transcription factor Met/Gce was identified as the JH intracellular receptor. In the presence of JH, with the assistance of Hsp83, and through physical association with a bHLH-PAS transcriptional co-activator, Met/Gce enters the nucleus and binds to E-box-like motifs in promoter regions of JH primary-response genes for inducing gene expression...
June 11, 2018: Insect Science
https://www.readbyqxmd.com/read/29867580/validity-and-reliability-of-the-30-s-continuous-jump-for-anaerobic-power-and-capacity-assessment-in-combat-sport
#6
Drazen Čular, Vladimir Ivančev, Alessandro M Zagatto, Mirjana Milić, Tea Beslija, Maha Sellami, Johnny Padulo
Cycling test such Wingate anaerobic test (WAnT) is used to measure anaerobic power (AP), but not anaerobic capacity (AC, i.e., the metabolic energy demand). However, in sports that do not involve cycling movements (Karate), the continuous jump for 30 s (vertical jumps for 30 s) has been extensively used to measure anaerobic performance in all young athletes. Limited information's are available concerning its validity and reliability especially in children. As such, the current study aimed to test validity and reliability of a continuous jumps test (the CJ30s), using WAnT as a reference...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29863591/individual-and-combined-effect-of-inter-repetition-rest-and-elastic-bands-on-jumping-potentiation-in-resistance-trained-men
#7
Brett S Nickerson, Tyler D Williams, Ronald L Snarr, Kyung-Shin Park
Nickerson, BS, Williams, TD, Snarr, RL, and Park, K-S. Individual and combined effect of inter-repetition rest and elastic bands on jumping potentiation in resistance-trained men. J Strength Cond Res XX(X): 000-000, 2018-The purpose of this study was to determine the individual and combined effects of cluster sets (CS) and elastic bands for jumping potentiation in resistance-trained men. Twelve resistance-trained men (age: 22 ± 3 years) participated in this study. In a random order, participants completed 1 set of 3 repetitions at 85% 1-repetition maximum for the parallel back squat: (a) traditional set with continuous repetitions; (b) continuous repetitions with elastic bands (BANDS); (c) CS with 30 seconds of rest between each repetition (CS30); and (d) CS with 30 seconds of rest between each repetition and elastic bands (CS + BANDS)...
May 30, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29852134/doxorubicin-conjugation-and-drug-linker-chemistry-alter-the-intravenous-and-pulmonary-pharmacokinetics-of-a-pegylated-generation-4-polylysine-dendrimer-in-rats
#8
Nathania J Leong, Dharmini Mehta, Victoria M McLeod, Brian D Kelly, Rashmi Pathak, David J Owen, Christopher Jh Porter, Lisa M Kaminskas
PEGylated polylysine dendrimers have demonstrated potential as inhalable drug delivery systems that can improve the treatment of lung cancers. Their treatment potential may be enhanced by developing constructs that display prolonged lung retention, together with good systemic absorption, the capacity to passively target lung tumours from the blood and highly selective, yet rapid liberation in the tumour microenvironment. This study sought to characterise how the nature of cathepsin B cleavable peptide linkers, used to conjugate doxorubicin to a PEGylated (PEG570) G4 polylysine dendrimer, affect drug liberation kinetics and intravenous and pulmonary pharmacokinetics in rats...
May 28, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29845724/remodeling-of-the-juvenile-hormone-pathway-through-caste-biased-gene-expression-and-positive-selection-along-a-gradient-of-termite-eusociality
#9
Evelien Jongepier, Carsten Kemena, Alberto Lopez-Ezquerra, Xavier Belles, Erich Bornberg-Bauer, Judith Korb
The evolution of division of labor between sterile and fertile individuals represents one of the major transitions in biological complexity. A fascinating gradient in eusociality evolved among the ancient hemimetabolous insects, ranging from noneusocial cockroaches through the primitively social lower termites-where workers retain the ability to reproduce-to the higher termites, characterized by lifetime commitment to worker sterility. Juvenile hormone (JH) is a prime candidate for the regulation of reproductive division of labor in termites, as it plays a key role in insect postembryonic development and reproduction...
May 29, 2018: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/29808785/habit-strength-and-between-meal-snacking-in-daily-life-the-moderating-role-of-level-of-education
#10
Saskia Wouters, Viviane Thewissen, Mira Duif, Rob Jh van Bree, Lilian Lechner, Nele Jacobs
OBJECTIVE: Recent research emphasizes the importance of habit in explaining patterns of energy intake and choices of consumption. However, the nature of the association between habit strength and snacking has not been explored for all types of between-meal snacks. DESIGN: Multilevel linear techniques were used to: (i) examine the association between habit strength and moment-to-moment energy intake (kilocalories) from snacks in daily life; and (ii) determine whether gender, age, level of education and BMI moderate the association between habit strength and moment-to-moment energy intake from snacks...
May 29, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29804837/ctcf-binding-elements-mediate-accessibility-of-rag-substrates-during-chromatin-scanning
#11
Suvi Jain, Zhaoqing Ba, Yu Zhang, Hai-Qiang Dai, Frederick W Alt
RAG endonuclease initiates antibody heavy chain variable region exon assembly from V, D, and J segments within a chromosomal V(D)J recombination center (RC) by cleaving between paired gene segments and flanking recombination signal sequences (RSSs). The IGCR1 control region promotes DJH intermediate formation by isolating Ds, JH s, and RCs from upstream VH s in a chromatin loop anchored by CTCF-binding elements (CBEs). How VH s access the DJH RC for VH to DJH rearrangement was unknown. We report that CBEs immediately downstream of frequently rearranged VH -RSSs increase recombination potential of their associated VH far beyond that provided by RSSs alone...
May 18, 2018: Cell
https://www.readbyqxmd.com/read/29804806/a-5-utr-overlapping-lncrna-activates-the-male-determining-gene-doublesex1-in-the-crustacean-daphnia-magna
#12
Yasuhiko Kato, Christelle Alexa G Perez, Nur Syafiqah Mohamad Ishak, Quang D Nong, Yuumi Sudo, Tomoaki Matsuura, Tadashi Wada, Hajime Watanabe
Long noncoding RNAs (lncRNAs) are pervasively transcribed in the eukaryotic genome [1] and are important for the control of master regulatory genes that are involved in cell differentiation and development [2, 3]. Here, we show that a 5' UTR-overlapping lncRNA regulates the male-specific expression of the DM-domain gene doublesex1 (dsx1) in the crustacean Daphnia magna, which produces males in response to environmental stimuli. This lncRNA, named doublesex1 alpha promoter-associated long RNA (DAPALR), is transcribed upstream the transcription start site (TSS) in a sense orientation and subjected to 5' end capping and 3' end processing at a stem-loop structure before the dsx1 coding exon...
May 11, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29804255/preparation-and-characterization-of-cs-%C3%AE-cd-nano-zno-composite-porous-membrane-optimized-by-box-behnken-for-the-adsorption-of-congo-red
#13
Xuechao Yan, Xiaoping Zhang, Qian Li
In this paper, an effective chitosan/beta-cyclodextrin/nanometer zinc oxide (CS/β-CD/Nano-ZnO) composite porous membrane was synthesized by sol-gel and polymer-assisted inverting method. Preparation conditions of CS/β-CD/Nano-ZnO were investigated by single-factor and Box-Behnken response surface methodology optimizing triethoxyvinylsilane (JH-V151), beta-cyclodextrin (β-CD), and nanometer zinc oxide (Nano-ZnO), and applied to study the adsorption characteristics of Cong red (CR) from aqueous solution using batch experiments...
May 26, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29803663/molecular-cloning-and-expression-analysis-of-a-prawn-macrobrachium-rosenbergii-juvenile-hormone-esterase-like-carboxylesterase-following-immune-challenge
#14
Xiao-Jing Zhu, Yanan Xiong, Weiran He, Yuting Jin, Yeqing Qian, Jun Liu, Zhong-Min Dai
Methyl farnesoate (MF), the crustacean juvenile hormone (JH), plays critical roles in various physiological processes in crustaceans. The titer of MF is precisely regulated by specific carboxylesterase. Here, we report for the first time that the cloning and expression analysis of a JH esterase-like carboxylesterase from the prawn Macrobrachium rosenbergii (named as MrCXE). MrCXE contained a 1935-bp open reading frame (ORF) conceptually translated into a 644-amino acids protein. MrCXE protein shared the highest identity (36%) with JH esterase-like carboxylesterase from the swimming crab, Portunus trituberculatus and exhibited the typical motifs of JH esterase-like carboxylesterases...
May 24, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29785088/insight-into-resistance-mechanism-of-anaplastic-lymphoma-kinase-to-alectinib-and-jh-viii-157-02-caused-by-g1202r-solvent-front-mutation
#15
Han Wang, Yao Wang, Wentao Guo, Bin Du, Xiaobing Huang, Riping Wu, Baoyu Yang, Xiaoyan Lin, Yilan Wu
Background: Mutated anaplastic lymphoma kinase (ALK) drives the development of advanced non-small cell lung cancer (NSCLC). Most reported small-molecule inhibitors targeting the ALK domain do not display good inhibition of the G1202R solvent front mutation. The solvent front mutation was assumed to hinder drug binding. However, a different fact could be uncovered by the simulations reported in this study through a structural analog of alectinib (JH-VIII-157-02), which demonstrated potent effects against the G1202R mutation...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29783696/jatrorrhizine-hydrochloride-suppresses-proliferation-migration-and-secretion-of-synoviocytes-in-vitro-and-ameliorates-rat-models-of-rheumatoid-arthritis-in-vivo
#16
Haiwen Qiu, Shengnan Sun, Xuemei Ma, Congcong Cui, Gang Chen, Zhenzhou Liu, Hui Li, Mei Liu
Jatrorrhizine hydrochloride (JH), an active component isolated from the traditional Chinese herb Coptis chinensis , has been reported to have antimicrobial, antitumor, antihypercholesterolemic, and neuroprotective activities. However, its antirheumatoid arthritis (RA) property remains unknown. In this study, a collagen-induced arthritis (CIA) rat model was used to evaluate the therapeutic effects of JH on RA by using arthritis score, radiological evaluation, and histopathological assessment. The in vitro effects of JH on proliferation, migration, and production of inflammatory mediators in RA-derived fibroblast-like synoviocyte MH7A cells were determined by the EdU incorporation assay, wound healing assay, real-time PCR, and ELISA, respectively...
May 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29780329/involvement-of-met-and-kr-h1-in-jh-mediated-reproduction-of-female-bactrocera-dorsalis-hendel
#17
Yong Yue, Rui-Lin Yang, Wei-Ping Wang, Qi-Hao Zhou, Er-Hu Chen, Guo-Rui Yuan, Jin-Jun Wang, Wei Dou
Juvenile hormone (JH) prevents metamorphosis during insect larval stages and promotes adult reproductive processes. Krüppel-homolog 1 (Kr-h1), a zinc finger transcription factor assumed to be induced by JH via the JH receptor methoprene-tolerant (Met), mediates the antimetamorphic effect of JH in insects, but its function in JH-mediated reproductive processes has not been fully explored. In this study, Met and Kr-h1 involved in the JH signaling pathway were first cloned and identified from the oriental fruit fly, Bactrocera dorsalis , an important pest infesting fruit and vegetables worldwide...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29755749/%C3%AF-%C3%AF-induced-aggregation-and-single-crystal-fluorescence-anisotropy-of-5-6-10b-tri-aza-acephenanthrylene
#18
Katarzyna Ostrowska, Davide Ceresoli, Katarzyna Stadnicka, Marlena Gryl, Marco Cazzaniga, Raffaella Soave, Bogdan Musielak, Łukasz J Witek, Piotr Goszczycki, Jarosław Grolik, Andrzej M Turek
The structural origin of absorption and fluorescence anisotropy of the single crystal of the π-conjugated heterocyclic system 5,6,10b-tri-aza-acephenan-thrylene, TAAP, is presented in this study. X-ray analysis shows that the crystal framework in the space group P [Formula: see text] is formed by centrosymmetric dimers of face-to-face mutually oriented TAAP molecules joined by π-π non-covalent interactions. The conformation of the TAAP molecule is stabilized by intramolecular C-H⋯N( sp 2 ), N( sp 2 )H⋯π(CN), and C-H⋯O( sp 2 ) hydrogen bonds...
May 1, 2018: IUCrJ
https://www.readbyqxmd.com/read/29754457/cardioprotective-role-of-igf-1-in-the-hypertrophied-myocardium-of-the-spontaneously-hypertensive-rats-a-key-effect-on-nhe-1-activity
#19
Alejandra M Yeves, Juan I Burgos, Andrés J Medina, M Celeste Villa-Abrille, Irene L Ennis
AIM: Myocardial Na+ /H+ exchanger-1 (NHE-1) hyperactivity and oxidative stress are interrelated phenomena playing pivotal roles in the development of pathological cardiac hypertrophy and heart failure. Exercise training is effective to convert pathological into physiological hypertrophy in the spontaneously hypertensive rats (SHR) and IGF-1 -key humoral mediator of exercise training- inhibits myocardial NHE-1, at least in normotensive rats. Therefore, we hypothesize that IGF-1 by hampering NHE-1 hyperactivity and oxidative stress should exert a cardioprotective effect in the SHR...
May 13, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29753023/reduced-left-ventricular-mechanical-dispersion-in-heart-failure-patients-undergoing-cardiac-resynchronisation-therapy-is-associated-with-superior-long-term-outcome
#20
Pieter van der Bijl, Mand Jh Khidir, Melissa Leung, Dilek Yilmaz, Bart Mertens, Nina Ajmone Marsan, Victoria Delgado, Jeroen J Bax
BACKGROUND: In heart failure (HF) patients, left ventricular mechanical dispersion (LVMD) reflects heterogeneous mechanical activation of the left ventricle. In HF patients, LVMD can be reduced after CRT. Whether lesser LVMD is associated with improved outcome is unknown. OBJECTIVE: To relate LVMD to long-term prognosis in a large cohort of HF patients after 6 months of cardiac resynchronization therapy (CRT). METHODS: Clinical, echocardiographic and ventricular arrhythmia (VA) data were analyzed from an ongoing registry of HF recipients of CRT...
May 9, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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