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R J Stratta, R R Alloway
Between 1966 and 1997, over 10 000 pancreas transplants were performed worldwide, 88% of these being simultaneous kidney-pancreas transplantations (SKPTs). The overall 1-year patient survival rate exceeds 90%, and the graft survival (complete insulin independence) rate is 80%. SKPT should be regarded as the treatment of choice in carefully selected patients with type 1 (insulin-dependent; IDDM) diabetes mellitus and advanced nephropathy, because of its ability to offer superior glycaemic control and an improved quality of life...
November 1998: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
T Genzini, G S Marchini, A J B A Chang, I Antunes, A Hayashi, H Abensur, L Kataoka, F Crescentini, J Egídio Romão, E B Rangel, M Perosa
Pancreas transplantation alone (PTA) has become an accepted treatment of nonuremic diabetic patients, when the risks of secondary complications of diabetes mellitus are greater than those of the surgical procedure and the posttransplant immunosuppression. As a decrease in native renal function is expected, we followed this parameter among patients who underwent PTA. From January 1997 through January 2005, we performed 69 PTA in 66 patients. All patients showed glucose hyperlability with hypoglycemic unawareness, or two or more diabetic complications as well as creatinine clearance (CrCl) > or = 45 mL/min...
July 2006: Transplantation Proceedings
Salient aspects of prolonged metabolic studies on seven excessively labile diabetic patients and a review of the literature concerning causation and therapy of brittle diabetes are presented. Brittleness is redefined as "a syndrome of excessive insulin-sensitivity and ketosis-proneness manifested by extreme and unexplainable short-term and long-term fluctuations in the parameters of the disease". Evidence on the causation of hyperlability points to dysfunction of plasma-protein transport and of hepatic and peripheral tissue metabolism of insulin...
April 18, 1964: Canadian Medical Association Journal
R J Stratta, L G Weide, R Sindhi, D Sudan, J T Jerius, J L Larsen, K Cushing, M T Grune, S J Radio
OBJECTIVE: To determine the safety and efficacy of solitary pancreas transplantation in the treatment of IDDM. RESEARCH DESIGN AND METHODS: A single-center retrospective case series of 62 consecutive solitary pancreas transplants (20 sequential pancreas after kidney, 42 pancreas transplants alone) performed in 57 adult IDDM patients was studied. Indications for solitary pancreas transplantation were 1) the presence of two or more overt diabetic complications and/or 2) glucose hyperlability with hypoglycemic unawareness and impaired quality of life...
March 1997: Diabetes Care
J C Pickup, P D Home, R W Bilous, H Keen, K G Alberti
Severely brittle diabetes is defined as a rare subtype of insulin-dependent diabetes with wide, fast, unpredictable, and inexplicable swings in blood glucose concentration, often culminating in ketoacidosis or hypoglycaemic coma. To assess the role of inappropriate type, amount, or timing of insulin treatment and the route of administration as a cause of severe brittleness six patients with continuous subcutaneous insulin infusion, which provides a high degree of optimisation of dosage with exogenous insulin in stable diabetics...
January 31, 1981: British Medical Journal (1981-1988)
K A Jacobs, V Shen, D Schlessinger
In an extract containing all the components for lac gene expression except washed ribosomes, lac mRNA formation was increased 4- to 6-fold by the addition of washed ribosomes. The formation of beta-galactosidase mRNA and enzyme showed very different dependency on added ribosomes. Enzyme was formed in proportion to the number of ribosomes added, whereas 10% of the standard level of ribosomes promoted full levels of transcription. Consistent with their action in vivo, chloramphenicol and erythromycin blocked the ribosome-dependent lac transcription...
January 1978: Proceedings of the National Academy of Sciences of the United States of America
L D Simon, M Gottesman, K Tomczak, S Gottesman
An Escherichia coli mutant, HDF026, defective for growth of phage T4, has been characterized biochemically and genetically. The mutant displays an elevated level of degradation of abnormal proteins, such as puromycyl polypeptides or canavanine-containing polypeptides. Genetically, HDF026 appears to be an allele of rho, which also encodes the transcription termination factor and RNA-dependent ATPase, Rho. The mutation contransduces by phage PI with ilv, weakly suppresses polar mutations in gal, and permits some growth of lambda N- phage...
April 1979: Proceedings of the National Academy of Sciences of the United States of America
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