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Cerebral small vessels disease

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https://www.readbyqxmd.com/read/29760289/-neurocognitive-disorders-other-than-alzheimer-disease-vascular-dementia
#1
Mari Yoshida
Vascular dementia involves several mechanism of pathogenesis. Cerebral small vessel diseases play a central role in vascular dementia, including sporadic cerebral small vessel diseases, cerebral autosomal-dominant or autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL or CARASIL), cerebral amyloid angiopathy, and amyloid β-related angiitis. Although these diseases have different pathomechanisms, chronic white matter hypoperfusion contributes to development of neuronal dysfunction as a common pathway in vascular dementia...
May 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29757481/severe-white-matter-astrocytopathy-in-cadasil
#2
Yoshiki Hase, Aiqing Chen, Letitia L Bates, Lucinda J L Craggs, Yumi Yamamoto, Elizabeth Gemmell, Arthur E Oakley, Viktor I Korolchuk, Raj N Kalaria
Objectives Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterised by strategic white matter (WM) hyperintensities on MRI. Pathological features include WM degeneration, arteriolosclerosis, lacunar infarcts and the deposition of granular osmiophilic material. Based on the hypothesis that the gliovascular unit is compromised, we assessed the nature of astrocyte damage in the deep WM of CADASIL subjects. Methods We evaluated post-mortem brains from CADASIL, cerebral small vessel disease, similar age cognitively normal and older control subjects...
May 14, 2018: Brain Pathology
https://www.readbyqxmd.com/read/29752348/genetic-study-of-white-matter-integrity-in-uk-biobank-n-8448-and-the-overlap-with-stroke-depression-and-dementia
#3
Loes C A Rutten-Jacobs, Daniel J Tozer, Marco Duering, Rainer Malik, Martin Dichgans, Hugh S Markus, Matthew Traylor
BACKGROUND AND PURPOSE: Structural integrity of the white matter is a marker of cerebral small vessel disease, which is the major cause of vascular dementia and a quarter of all strokes. Genetic studies provide a way to obtain novel insights in the disease mechanism underlying cerebral small vessel disease. The aim was to identify common variants associated with microstructural integrity of the white matter and to elucidate the relationships of white matter structural integrity with stroke, major depressive disorder, and Alzheimer disease...
May 11, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29751260/forkhead-box-c1-gene-variant-causing-glaucoma-and-small-vessel-angiopathy-can-mimic-multiple-sclerosis
#4
Jagannadha R Avasarala, Julie R Jones, Curtis R Rogers
A 34-year old Caucasian female was initially diagnosed with multiple small-vessel strokes at age 20 years which were etiologically classified as secondary to anti-phospholipid antibody syndrome (APS) although she had no history or laboratory data to suggest APS. Based on her MRI of brain findings, one of her neurologists was concerned she could have multiple sclerosis (MS) and hence the patient was referred to our clinic for further evaluation. The patient's MRI of brain showed confluent lesions in the periventricular and juxta-cortical lesions that fulfil 2017 McDonald criteria for dissemination in space...
April 21, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29748646/the-effect-of-the-total-small-vessel-disease-burden-on-the-structural-brain-network
#5
Xiaopei Xu, Kui Kai Lau, Yuen Kwun Wong, Henry K F Mak, Edward S Hui
Different cerebral small vessel disease (SVD) lesion types have been shown to disrupt structural brain network individually. Considering that they often coexist, we investigated the relation between their collective effect using the recently proposed total SVD score and structural brain network on MRI in 95 patients with first transient ischemic attack (TIA) or ischemic stroke. Fifty-nine patients with and 36 without any SVD lesions were included. The total SVD score was recorded. Diffusion tensor imaging was performed to estimate structural brain connections for subsequent brain connectivity analysis...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29745919/type-2-diabetes-mellitus-and-cerebral-small-vessel-disease-case-report
#6
S Sopromadze
Patients with type 2 diabetes mellitus have an increased risk of cardiovascular (CV) morbidity and mortality. Recently, brain has been described also as a target organ for diabetic microvascular complications. Cerebral small vessel disease (SVD) may cause lacunar infarcts and cognitive dysfunction. In our case a brain MRI scan showed distinct lesions, which are mainly caused and seen by long lasting diabetes and hypertension.
April 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29744799/dti-derived-indexes-of-brain-wm-correlate-with-cognitive-performance-in-vascular-mci-and-small-vessel-disease-a-tbss-study
#7
Mario Mascalchi, Emilia Salvadori, Nicola Toschi, Marco Giannelli, Stefano Orsolini, Stefano Ciulli, Andrea Ginestroni, Anna Poggesi, Antonio Giorgio, Francesca Lorenzini, Marco Pasi, Nicola De Stefano, Leonardo Pantoni, Domenico Inzitari, Stefano Diciotti
Indexes derived from diffusion tensor imaging (DTI) are sensitive to changes of both T2-hyperintense and normal-appearing brain white matter (WM) in elderly subjects with variable cognitive status. We investigated correlations between global cognitive performance and DTI-derived indexes along the WM tracts in the brain of patients with vascular mild cognitive impairment (MCI) and small vessel disease (SVD). Seventy-six patients with vascular MCI and SVD were assessed through Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE) test and underwent DTI examination on a 1...
May 9, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29739911/effect-of-antihypertensive-medication-on-cerebral-small-vessel-disease-a-systematic-review-and-meta-analysis
#8
Tessa van Middelaar, Tanja E Argillander, Floris H B M Schreuder, Jaap Deinum, Edo Richard, Catharina J M Klijn
BACKGROUND AND PURPOSE: Hypertension is an important risk factor for cerebral small vessel disease. We aimed to study the effect of antihypertensive medication (AHM) on the progression of cerebral small vessel disease. METHODS: We performed a systematic literature search of electronic databases up to January 30, 2017, for randomized controlled trials on the effect of AHM on ≥1 cerebral small vessel disease magnetic resonance imaging markers (ie, white matter hyperintensities, lacunes, microbleeds, enlarged perivascular spaces, acute small subcortical infarcts, and brain atrophy) after ≥1 year...
May 8, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29736422/cerebral-microbleeds-and-blood-pressure-abnormalities-in-parkinson-s-disease
#9
Kazuo Yamashiro, Ryota Tanaka, Yasushi Shimo, Genko Oyama, Takashi Ogawa, Atsushi Umemura, Nobutaka Hattori
Blood pressure abnormalities are frequently observed in patients with Parkinson's disease (PD), and are associated with cerebrovascular diseases such as white matter hyperintensities and carotid atherosclerosis. We assessed the relationship between blood pressure abnormalities and cerebral microbleeds (CMBs), a marker of cerebral small vessel disease, in 128 patients with PD. We examined supine and orthostatic blood pressures and used 24-hour ambulatory blood pressure monitoring to assess the presence or absence of orthostatic hypotension (OH), supine hypertension (SH), nocturnal hypertension (NH), and loss of nocturnal blood pressure dips (non-dipping)...
March 2018: ENeurologicalSci
https://www.readbyqxmd.com/read/29726891/understanding-the-role-of-the-perivascular-space-in-cerebral-small-vessel-disease
#10
Rosalind Brown, Helene Benveniste, Sandra E Black, Serge Charpak, Martin Dichgans, Anne Joutel, Maiken Nedergaard, Kenneth J Smith, Berislav V Zlokovic, Joanna M Wardlaw
Small vessel diseases are a group of disorders that result from pathological alteration of the small blood vessels in the brain, including the small arteries, capillaries and veins. Of the 35-36 million people that are estimated to suffer from dementia worldwide, up to 65% have an SVD component. Furthermore, SVD causes 20-25% of strokes, worsens outcome after stroke and is a leading cause of disability, cognitive impairment and poor mobility. Yet the underlying cause(s) of SVD are not fully understood.Magnetic resonance imaging (MRI) has confirmed enlarged perivascular spaces (PVS) as a hallmark feature of SVD...
May 2, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29725820/cadasil-brain-vessels-show-a-htra1-loss-of-function-profile
#11
Andreas Zellner, Eva Scharrer, Thomas Arzberger, Chio Oka, Valérie Domenga-Denier, Anne Joutel, Stefan F Lichtenthaler, Stephan A Müller, Martin Dichgans, Christof Haffner
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and a phenotypically similar recessive condition (CARASIL) have emerged as important genetic model diseases for studying the molecular pathomechanisms of cerebral small vessel disease (SVD). CADASIL, the most frequent and intensely explored monogenic SVD, is characterized by a severe pathology in the cerebral vasculature including the mutation-induced aggregation of the Notch3 extracellular domain (Notch3ECD ) and the formation of protein deposits of insufficiently determined composition in vessel walls...
May 3, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29712883/small-vessels-dementia-and-chronic-diseases-molecular-mechanisms-and-pathophysiology
#12
REVIEW
Karen Horsburgh, Joanna M Wardlaw, Tom van Agtmael, Stuart M Allan, Mike L J Ashford, Philip M Bath, Rosalind Brown, Jason Berwick, M Zameel Cader, Roxana O Carare, John B Davis, Jessica Duncombe, Tracy D Farr, Jill H Fowler, Jozien Goense, Alessandra Granata, Catherine N Hall, Atticus H Hainsworth, Adam Harvey, Cheryl A Hawkes, Anne Joutel, Rajesh N Kalaria, Patrick G Kehoe, Catherine B Lawrence, Andy Lockhart, Seth Love, Malcolm R Macleod, I Mhairi Macrae, Hugh S Markus, Chris McCabe, Barry W McColl, Paul J Meakin, Alyson Miller, Maiken Nedergaard, Michael O'Sullivan, Terry J Quinn, Rikesh Rajani, Lisa M Saksida, Colin Smith, Kenneth J Smith, Rhian M Touyz, Rebecca C Trueman, Tao Wang, Anna Williams, Steven C R Williams, Lorraine M Work
Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation...
April 30, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29710119/cerebral-microbleeds-and-the-effect-of-intensive-blood-pressure-reduction-on-hematoma-expansion-and-functional-outcomes-a-secondary-analysis-of-the-atach-2-randomized-clinical-trial
#13
Ashkan Shoamanesh, Andrea Morotti, Javier M Romero, Jamary Oliveira-Filho, Frieder Schlunk, Michael J Jessel, Alison M Ayres, Anastasia Vashkevich, Kristin Schwab, Mohammad R Afzal, Christy Cassarly, Renee H Martin, Adnan I Qureshi, Steven M Greenberg, Jonathan Rosand, Joshua N Goldstein
Importance: Response to intensive blood pressure (BP) lowering in acute intracerebral hemorrhage (ICH) might vary with the degree of underlying cerebral small vessel disease. Objectives: To characterize cerebral microbleeds (CMBs) in acute ICH and to assess the potential for interaction between underlying small vessel disease (as indicated by CMB number and location) and assignment to acute intensive BP targeting for functional outcomes and hematoma expansion. Design, Setting, and Participants: Preplanned subgroup analyses in the Antihypertensive Treatment of Acute Cerebral Hemorrhage 2 (ATACH-2) trial were performed...
April 16, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29706439/recognition-of-cerebral-autosomal-dominant-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy-cadasil-in-two-oligosymptomatic-sisters-with-low-cadasil-scale-scores-and-a-venous-dysplasia-report-of-a-novel-greek-family
#14
George P Paraskevas, Vasilios C Constantinides, Christos Yapijakis, Evangelia Kararizou, Elisabeth N Kapaki, Anastasia Bougea
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) due to mutations of the NOTCH3 gene is the most common cause of inherited cerebral small-vessel disease and one of the genetic causes of migraine with aura. The so-called CADASIL scale has been proposed as a clinical screening tool, and a score of 15 or higher seems useful in identifying patients with high probability of carrying NOTCH3 mutations. We studied a novel Greek family with clinical features compatible with CADASIL...
April 26, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29703772/-col4a1-2-cnvs-and-cerebral-small-vessel-disease-narrowing-in-on-the-critical-chromosomal-region
#15
Avi Saskin, Guillaume Sillon, Natalie Palfreeman, Daniela Buhas
No abstract text is available yet for this article.
April 27, 2018: Neurology
https://www.readbyqxmd.com/read/29699507/high-resolution-magnetic-resonance-imaging-in-pathogenesis-diagnosis-of-single-lenticulostriate-infarction-with-nonstenotic-middle-cerebral-artery-a-retrospective-study
#16
Li-Li Sun, Zhong-Hao Li, Wen-Xiong Tang, Lei Liu, Fei-Yan Chang, Xue-Bin Zhang, Wei-Jie Ye, Shuo Lu, Zun-Jing Liu, Xian-Jin Zhu
BACKGROUND: It is usually difficult to identify stroke pathogenesis for single lenticulostriate infarction with nonstenotic middle cerebral artery (MCA). Our aim is to differentiate the two pathogeneses, non-branch atheromatous small vessel disease and branch atheromatous disease (BAD) by high-resolution magnetic resonance imaging (HR-MRI). METHODS: Thirty-two single lenticulostriate infarction patients with nonstenotic MCA admitted to the China-Japan Friendship Hospital from December 2014 to August 2017 were enrolled for retrospective analysis...
April 25, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29695593/longitudinal-decline-in-structural-networks-predicts-dementia-in-cerebral-small-vessel-disease
#17
Andrew J Lawrence, Eva A Zeestraten, Philip Benjamin, Christian P Lambert, Robin G Morris, Thomas R Barrick, Hugh S Markus
OBJECTIVE: To determine whether longitudinal change in white matter structural network integrity predicts dementia and future cognitive decline in cerebral small vessel disease (SVD). To investigate whether network disruption has a causal role in cognitive decline and mediates the association between conventional MRI markers of SVD with both cognitive decline and dementia. METHODS: In the prospective longitudinal SCANS (St George's Cognition and Neuroimaging in Stroke) Study, 97 dementia-free individuals with symptomatic lacunar stroke were followed with annual MRI for 3 years and annual cognitive assessment for 5 years...
April 25, 2018: Neurology
https://www.readbyqxmd.com/read/29689412/non-invasive-through-skull-brain-vascular-imaging-and-small-tumor-diagnosis-based-on-nir-ii-emissive-lanthanide-nanoprobes-beyond-1500-nm
#18
Zhenluan Xue, Songjun Zeng, Jianhua Hao
Optical bioimaging by using the new short-wavelength infrared window (SWIR, also named as NIR-II, 1000-1700 nm) is emerged as a next generation imaging technique for disease diagnosis owing to the unprecedented improvements in imaging sensitivity and spatial resolution. However, it is challenging to search new imaging agents with highly biocompatible and bright narrow-band emission located in the 1500-1700 nm (referred as NIR-IIb) region. Here we developed high quality polyacrylic acid (PAA) modified NaYF4 :Gd/Yb/Er nanorods (PAA-NRs) with remarkably enhanced NIR-IIb emission and decent bio-compatibility for in vivo cerebral vascular bioimaging and small tumor visualization...
April 17, 2018: Biomaterials
https://www.readbyqxmd.com/read/29687698/microcirculatory-dysfunction-in-the-heart-and-the-brain
#19
Hernán Mejía-Rentería, Jordi A Matias-Guiu, Francesco Lauri, Miguel Yus, Javier Escaned
Coronary microcirculatory dysfunction is a major cause of myocardial ischemia that influences the outcomes of patients with coronary artery disease. The mechanisms of coronary microcirculatory dysfunction are heterogeneous and may result from a spectrum of biological and cardiovascular risk factors that may affect also the microcirculation of other vital organs. Microcirculatory dysfunction of the brain, known as cerebral small vessel disease, is increasingly being recognized as a cause of cognitive decline and neurodegenerative disorders...
April 20, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29686024/causal-impact-of-type-2-diabetes-mellitus-on-cerebral-small-vessel-disease-a-mendelian-randomization-analysis
#20
Junfeng Liu, Loes Rutten-Jacobs, Ming Liu, Hugh S Markus, Matthew Traylor
BACKGROUND AND PURPOSE: The relationship between type 2 diabetes mellitus (T2D) and cerebral small vessel disease (CSVD) is unclear. We aimed to examine the causal effect of T2D, fasting glucose levels, and higher insulin resistance on CSVD using Mendelian randomization. METHODS: Five CSVD phenotypes were studied; 2 were clinical outcomes associated with CSVD (lacunar stroke: n=2191/27 297 and intracerebral hemorrhage [ICH]: n=2254/8195 [deep and lobar ICH]), whereas 3 were radiological markers of CSVD (white matter hyperintensities: n=8429; fractional anisotropy [FA]: n=8357; and mean diffusivity: n=8357)...
April 23, 2018: Stroke; a Journal of Cerebral Circulation
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