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https://www.readbyqxmd.com/read/29741124/clinical-commentary-on-late-onset-neutropenia-and-neurological-relapse-during-long-term-rituximab-therapy-in-mog-antibody-spectrum-disorder
#1
Yael Hacohen, Wallace J Brownlee
No abstract text is available yet for this article.
May 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29741120/late-onset-neutropenia-and-neurological-relapse-during-long-term-rituximab-therapy-in-myelin-oligodendrocyte-glycoprotein-antibody-spectrum-disorder
#2
Damien Biotti, Fleur Lerebours, Fabrice Bonneville, Jonathan Ciron, Michel Clanet, David Brassat
Late-onset neutropenia after rituximab therapy (LONART) is defined as a fall in the absolute neutrophil count below 500/mm3 at least 3 weeks after rituximab infusion, in the absence of any other explanation. LONART is rare during dysimmune conditions but can be life-threatening. We report on two patients with LONART and associated neurological relapse occurring in myelin oligodendrocyte glycoprotein (MOG)-antibody spectrum disorders. Rituximab was reintroduced in one patient, while the second patient was switched to tocilizumab...
May 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29724224/mog-encephalomyelitis-international-recommendations-on-diagnosis-and-antibody-testing
#3
REVIEW
S Jarius, F Paul, O Aktas, N Asgari, R C Dale, J de Seze, D Franciotta, K Fujihara, A Jacob, H J Kim, I Kleiter, T Kümpfel, M Levy, J Palace, K Ruprecht, A Saiz, C Trebst, B G Weinshenker, B Wildemann
Over the past few years, new-generation cell-based assays have demonstrated a robust association of autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) optic neuritis, myelitis and brainstem encephalitis, as well as with acute disseminated encephalomyelitis (ADEM)-like presentations. Most experts now consider MOG-IgG-associated encephalomyelitis (MOG-EM) a disease entity in its own right, immunopathogenetically distinct from both classic multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorders (NMOSD)...
May 3, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29721683/pediatric-neuromyelitis-optica-spectrum-disorders
#4
REVIEW
Grace Y Gombolay, Tanuja Chitnis
PURPOSE OF REVIEW: Neuromyelitis optica spectrum disorders (NMOSDs) are a group of inflammatory and demyelinating disorders of the central nervous system that can occur in children and adults. The classic presentation of NMOSD is characterized by optic neuritis and transverse myelitis, but other presentations are also recognized, expanding the disease as NMO spectrum disorders. The purpose of this review is to discuss the clinical features, along with management and treatment options, including potential future therapeutic options, in pediatric NMOSD...
May 2, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29695592/clinical-spectrum-and-prognostic-value-of-cns-mog-autoimmunity-in-adults-the-mogador-study
#5
Alvaro Cobo-Calvo, Anne Ruiz, Elisabeth Maillart, Bertrand Audoin, Helene Zephir, Bertrand Bourre, Jonathan Ciron, Nicolas Collongues, David Brassat, Francois Cotton, Caroline Papeix, Francoise Durand-Dubief, David Laplaud, Romain Deschamps, Mikaël Cohen, Damien Biotti, Xavier Ayrignac, Caroline Tilikete, Eric Thouvenot, Bruno Brochet, Cecile Dulau, Thibault Moreau, Ayman Tourbah, Pierre Lebranchu, Laure Michel, Christine Lebrun-Frenay, Alexis Montcuquet, Guillaume Mathey, Marc Debouverie, Jean Pelletier, Pierre Labauge, Nathalie Derache, Marc Coustans, Fabien Rollot, Jérôme De Seze, Sandra Vukusic, Romain Marignier
OBJECTIVE: To describe clinical and radiologic features associated with myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) in a large French nationwide adult cohort, to assess baseline prognostic features of MOG-Ab-associated diseases after a first acute demyelinating syndrome, and to evaluate the clinical value of MOG-Ab longitudinal analysis. METHODS: Clinical data were obtained from 197 MOG-Ab-positive patients ≥18 years of age. Complete imaging data were available in 108, and 54 serum samples were eligible for longitudinal evaluation...
April 25, 2018: Neurology
https://www.readbyqxmd.com/read/29685427/neuromyelitis-optica-spectrum-disorders-features-of-aquaporin-4-myelin-oligodendrocyte-glycoprotein-and-double-seronegative-mediated-subtypes
#6
REVIEW
C Alves Do Rego, N Collongues
The new diagnostic classification of neuromyelitis optica spectrum disorder (NMOSD) in 2015 highlights the central role of biomarkers, such as antibodies against aquaporin-4 (AQP4-Ab), in diagnosis. Also, in approximately 20-25% of patients without AQP4-Ab (NMOSDAQP4- ) the presence of an antibody directed against myelin oligodendrocyte glycoprotein (MOG) characterizes a specific population of NMOSD patients (NMOSDMOG+ ), according to their demographic and clinical data and prognoses. While double-seronegative cases (NMOSDNEG ) have not been fully described, they may correspond to the very first patients with opticospinal demyelination reported by Devic and Gault in 1894...
April 20, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29670575/mog-igg-associated-optic-neuritis-encephalitis-and-myelitis-lessons-learned-from-neuromyelitis-optica-spectrum-disorder
#7
REVIEW
Giordani Rodrigues Dos Passos, Luana Michelli Oliveira, Bruna Klein da Costa, Samira Luisa Apostolos-Pereira, Dagoberto Callegaro, Kazuo Fujihara, Douglas Kazutoshi Sato
Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been found in some cases diagnosed as seronegative neuromyelitis optica spectrum disorder (NMOSD). MOG-IgG allowed the identification of a subgroup with a clinical course distinct from that of NMOSD patients who are seropositive for aquaporin-4-IgG antibodies. MOG-IgG is associated with a wider clinical phenotype, not limited to NMOSD, with the majority of cases presenting with optic neuritis (ON), encephalitis with brain demyelinating lesions, and/or myelitis...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29661590/rituximab-was-effective-for-acute-disseminated-encephalomyelitis-followed-by-recurrent-optic-neuritis-with-anti-myelin-oligodendrocyte-glycoprotein-antibodies
#8
Masako Nagashima, Hitoshi Osaka, Takahiro Ikeda, Ayumi Matsumoto, Akihiko Miyauchi, Kimihiko Kaneko, Ichiro Nakashima, Yuko Nakano, Kei Wakabayashi, Yukifumi Monden, Takanori Yamagata
BACKGROUND: The effect of rituximab on acute disseminated encephalomyelitis (ADEM) followed by recurrent optic neuritis (ON) is not yet known. PATIENT: We are reporting the case of a 4-year-old Japanese girl who was diagnosed with anti-myelin oligodendrocyte glycoprotein (MOG) antibody positive ADEM followed by recurrent ON. She developed altered mental status, left facial paralysis, left paresis, and experienced three episodes of ON. She was treated with rituximab and azathioprine (AZA) as prevention for recurrent ON...
April 13, 2018: Brain & Development
https://www.readbyqxmd.com/read/29661538/an-unusual-case-of-anti-mog-cns-demyelination-with-concomitant-mild-anti-nmdar-encephalitis
#9
Jiajia Zhou, Winwen Tan, Suyin Elaine Tan, Jing Hu, Zhongqin Chen, Kang Wang
We report the case of a patient who presented with progressive unsteadiness and narcoleptic attacks followed by behavioral change and psychosis, without visual disturbances or seizures. MRI revealed multiple areas of fluid attenuation inversion recovery (FLAIR) high-intensity lesions involving the cerebellum, brainstem, thalamus and third ventricular peri-ependymal region consistent with demyelination. Both the serum myelin oligodendrocyte glycoprotein-antibodies (MOG-Abs) and cerebral spinal fluid (CSF) anti-N-methyl-d-as-partate receptor (NMDAR) antibodies were positive using transfected cell based assays...
April 6, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29629942/paediatric-multiple-sclerosis-and-other-acute-demyelinating-diseases
#10
Kevin Rostásy, Barbara Bajer-Kornek
PURPOSE OF REVIEW: Neuroimmunological diseases encompass a wide spectrum of diseases in children. Apart from the discovery of autoantibodies affecting primarily grey matter structures and the improved clinical characterization of rare entities such as N-methyl D-aspartate receptor-R- encephalitis, important strides have also been made in autoimmune-mediated white matter diseases, including paediatric multiple sclerosis (pedMS) and other acute demyelinating syndromes (ADS) often associated with antibodies (abs) against myelin-oligodendrocyte-glycoprotein (MOG)...
June 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29623106/defining-distinct-features-of-anti-mog-antibody-associated-central-nervous-system-demyelination
#11
REVIEW
Martin S Weber, Tobias Derfuss, Imke Metz, Wolfgang Brück
Extensive research over the last decades basically failed to identify a common cause of noninfectious inflammatory central nervous system (CNS) demyelinating disease. To a great extent, this may reflect that the group of inflammatory CNS demyelinating disorders likely contains multiple pathogenetically distinct disease entities. Indeed, the greatest success so far in deciphering the pathogenesis of a CNS demyelinating disorder resulted from the discovery of anti-aquaporin (AQP)-4 antibodies (ab), which allowed progressive delineation of neuromyelitis optica (NMO), formerly considered a variant of the most common CNS demyelinating disorder, multiple sclerosis (MS), as a distinct disease...
2018: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/29571858/anti-myelin-oligodendrocyte-glycoprotein-mog-antibodies-in-patients-with-optic-neuritis-and-seizures
#12
Josef Maxwell Gutman, Mark Kupersmith, Steven Galetta, Ilya Kister
We describe four patients who experienced optic neuritis (ON) and seizures and were found to have antibodies to myelin oligodendrocyte glycoprotein (MOG) in serum. The index case was a previously healthy 39-year-old man who developed steroid dependent ON and had a generalized seizure when steroids were tapered. He tested positive for antibodies to MOG. We have reviewed the charts of all 11 anti-MOG antibody positive patients in our practice and found that 4 patients, all of whom had experienced one or more episodes of ON, also had a generalized seizure during the course of their illness...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29571849/oligoclonal-bands-and-periventricular-lesions-in-multiple-sclerosis-will-not-increase-blood-brain-barrier-permeability
#13
Tetsuya Akaishi, Toshiyuki Takahashi, Ichiro Nakashima
OBJECTIVE: To elucidate the etiology and clinical significance of periventricular lesions (PVLs) and oligoclonal bands (OB) in multiple sclerosis (MS). METHODS: We enrolled a total of 97 MS patients (67 OB-positive and 30 OB-negative) who were negative both for anti-aquaporin-4 (AQP4) autoantibody and anti-myelin oligodendrocyte glycoprotein (MOG) antibody. In these patients, comprehensive data including clinical, laboratory, and MRI were collected to investigate the significance of OB and PVLs...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29568992/igg-synthesis-rate-and-anti-myelin-oligodendrocyte-glycoprotein-antibody-in-csf-may-be-associated-with-the-onset-of-cns-demyelination-after-haplo-hsct
#14
Xiao-Hui Zhang, Xin Zhao, Chen-Cong Wang, Wei Han, Huan Chen, Yu-Hong Chen, Feng-Rong Wang, Jing-Zhi Wang, Yuan-Yuan Zhang, Xiao-Dong Mo, Yao Chen, Yu Wang, Hai-Xia Fu, Ying-Jun Chang, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang
Haploidentical hematopoietic stem cell transplant (haplo-HSCT) is an upfront and effective therapy for hematology patients, but it usually has many complications, such as neurological complications. As one of the neurological complications following haplo-HSCT, immune-mediated demyelinating diseases of the central nervous system (CNS) seriously affect a patient's quality of life. However, the incidence, risk factors, and pathogenesis of CNS demyelination are not very well understood. Thirty of the 1526 patients (1...
March 22, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29554927/mog-igg-in-primary-and-secondary-chronic-progressive-multiple-sclerosis-a-multicenter-study-of-200-patients-and-review-of-the-literature
#15
S Jarius, K Ruprecht, J P Stellmann, A Huss, I Ayzenberg, A Willing, C Trebst, M Pawlitzki, A Abdelhak, T Grüter, F Leypoldt, J Haas, I Kleiter, H Tumani, K Fechner, M Reindl, F Paul, B Wildemann
BACKGROUND: Antibodies to human full-length myelin oligodendrocyte glycoprotein (MOG-IgG) as detected by new-generation cell-based assays have recently been described in patients presenting with acute demyelinating disease of the central nervous system, including patients previously diagnosed with multiple sclerosis (MS). However, only limited data are available on the relevance of MOG-IgG testing in patients with chronic progressive demyelinating disease. It is unclear if patients with primary progressive MS (PPMS) or secondary progressive MS (SPMS) should routinely be tested for MOG-IgG...
March 19, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29544193/autoimmune-and-immunogenetic-profile-of-patients-with-optic-neuritis-in-a-population-based-cohort
#16
K Soelberg, A C Nilsson, C Nielsen, S Jarius, M Reindl, B Wildemann, S T Lillevang, N Asgari
BACKGROUND: Optic neuritis (ON) is an inflammatory optic neuropathy, where the genetic and autoimmune dependency remains poorly characterized. OBJECTIVE: To investigate autoimmune and immunogenetic aspects of ON. METHOD: In a prospective population-based cohort 51 patients with ON were included. At follow up 20 patients had progressed to multiple sclerosis (MS-ON). All patients were screened for neuronal and systemic autoantibodies. HLA genotypes and allele and genotype frequencies of the PTPN22 C1858T and the PD-1...
March 7, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29524760/new-clinical-implications-of-anti-myelin-oligodendrocyte-glycoprotein-antibodies-in-children-with-cns-demyelinating-diseases
#17
REVIEW
Franziska Di Pauli, Markus Reindl, Thomas Berger
Acquired demyelinating CNS syndromes include a broad spectrum of clinical phenotypes and different entities can overlap. Therefore, differential diagnosis is still challenging. A humoral immune reaction against myelin oligodendrocyte glycoprotein (MOG) is present in a subgroup of these patients, particularly in children. Anti-MOG antibodies indicate a non-multiple sclerosis disease course. Indeed, early publications have suggested that anti-MOG antibodies argue for a monophasic course; recently an association with a high risk for recurrent non-MS disease has been shown...
February 22, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29517994/fatty-acids-dietary-supplements-exert-anti-inflammatory-action-and-limit-ganglion-cell-degeneration-in-the-retina-of-the-eae-mouse-model-of-multiple-sclerosis
#18
Massimo Dal Monte, Maurizio Cammalleri, Filippo Locri, Rosario Amato, Stefania Marsili, Dario Rusciano, Paola Bagnoli
Optic neuritis is an acute inflammatory demyelinating disorder of the optic nerve (ON) and is an initial symptom of multiple sclerosis (MS). Optic neuritis is characterized by ON degeneration and retinal ganglion cell (RGC) loss that contributes to permanent visual disability and lacks a reliable treatment. Here, we used the experimental autoimmune encephalomyelitis (EAE) mouse model of MS, a well-established model also for optic neuritis. In this model, C57BL6 mice, intraperitoneally injected with a fragment of the myelin oligodendrocyte glycoprotein (MOG), were found to develop inflammation, Müller cell gliosis, and infiltration of macrophages with increased production of oncomodulin (OCM), a calcium binding protein that acts as an atypical trophic factor for neurons enabling RGC axon regeneration...
March 8, 2018: Nutrients
https://www.readbyqxmd.com/read/29470571/prevalence-of-myelin-oligodendrocyte-glycoprotein-and-aquaporin-4-igg-in-patients-in-the-optic-neuritis-treatment-trial
#19
John J Chen, W Oliver Tobin, Masoud Majed, Jiraporn Jitprapaikulsan, James P Fryer, Jacqueline A Leavitt, Eoin P Flanagan, Andrew McKeon, Sean J Pittock
Importance: Autoantibodies to aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) are recently established biomarkers of autoimmune optic neuritis whose frequency and accompanying phenotype, especially for MOG-IgG, are still being characterized. The Optic Neuritis Treatment Trial (ONTT) was a well-known randomized clinical trial in optic neuritis; therefore, knowledge of the serostatus and accompanying phenotype of these patients would be useful to determine the frequency of these antibodies in patients presenting with typical monocular optic neuritis and their outcomes...
April 1, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29468668/myelin-oligodendrocyte-glycoprotein-and-aquaporin-4-antibodies-are-highly-specific-in-children-with-acquired-demyelinating-syndromes
#20
Sophie Duignan, Sukhvir Wright, Tom Rossor, John Cazabon, Kimberly Gilmour, Olga Ciccarelli, Evangeline Wassmer, Ming Lim, Cheryl Hemingway, Yael Hacohen
AIM: Our objectives were to evaluate the utility of measuring myelin oligodendrocyte glycoprotein (MOG) and aquaporin-4 (AQP4) antibodies (Ab) in clinical practice and describe their associated neurological phenotypes in children. METHOD: Between 2012 and 2017, 371 children with suspected acquired demyelinating syndromes (ADS) seen in three tertiary centres were tested for MOG-Ab and AQP4-Ab. Medical notes were retrospectively reviewed, and clinical and demographic data compiled...
February 22, 2018: Developmental Medicine and Child Neurology
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