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https://www.readbyqxmd.com/read/29162133/humoral-response-in-experimental-autoimmune-encephalomyelitis-targets-neural-precursor-cells-in-the-central-nervous-system-of-naive-rodents
#1
Evangelia Kesidou, Olga Touloumi, Roza Lagoudaki, Evangelia Nousiopoulou, Paschalis Theotokis, Kyriaki-Nepheli Poulatsidou, Marina Boziki, Evangelia Kofidou, Nickoleta Delivanoglou, Fani Minti, Georgios Hadjigeorgiou, Nikolaos Grigoriadis, Constantina Simeonidou
BACKGROUND: Neural precursor cells (NPCs) located in the subventricular zone (SVZ), a well-defined NPC niche, play a crucial role in central nervous system (CNS) homeostasis. Moreover, NPCs are involved in the endogenous reparative process both in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). However, the possibility that NPCs may be vulnerable to immune-related components may not be ruled out. Therefore, we investigated the potential affinity of myelin oligodendrocyte glycoprotein (MOG)-induced humoral response(s) to NPCs...
November 21, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29153600/subclinical-retinal-atrophy-in-the-unaffected-fellow-eyes-of-multiple-sclerosis-and-neuromyelitis-optica
#2
Tetsuya Akaishi, Kimihiko Kaneko, Noriko Himori, Takayuki Takeshita, Toshiyuki Takahashi, Toru Nakazawa, Masashi Aoki, Ichiro Nakashima
We compared the retinal thickness in the unaffected eyes among the following subtypes of unilateral optic neuritis (ON): multiple sclerosis (MS-ON), neuromyelitis optica spectrum disorder with anti-AQP4 autoantibody (AQP4-ON), patients with serum anti-MOG antibody (MOG-ON), and idiopathic ON. In the chronic phase, macular GCC and circum-papillary RNFL in the unaffected eyes were both atrophied in MS-ON and AQP4-ON, but were not atrophied in the others. Titers of anti-AQP4-Ab was suggested to be associated with such latent neurodegenerative process in AQP4-ON...
December 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29142145/clinical-course-therapeutic-responses-and-outcomes-in-relapsing-mog-antibody-associated-demyelination
#3
Sudarshini Ramanathan, Shekeeb Mohammad, Esther Tantsis, Tina Kim Nguyen, Vera Merheb, Victor S C Fung, Owen Bruce White, Simon Broadley, Jeannette Lechner-Scott, Steve Vucic, Andrew P D Henderson, Michael Harry Barnett, Stephen W Reddel, Fabienne Brilot, Russell C Dale
OBJECTIVE: We characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination. METHODS: We evaluated clinical phenotypes, annualised relapse rates (ARR) prior and on immunotherapy and Expanded Disability Status Scale (EDSS), in 218 demyelinating episodes from 33 paediatric and 26 adult patients. RESULTS: The most common initial presentation in the cohort was optic neuritis (ON) in 54% (bilateral (BON) 32%, unilateral (UON) 22%), followed by acute disseminated encephalomyelitis (ADEM) (20%), which occurred exclusively in children...
November 15, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29141829/cerebral-cortical-encephalitis-followed-by-recurrent-cns-demyelination-in-a-patient-with-concomitant-anti-mog-and-anti-nmda-receptor-antibodies
#4
Lei Zhou, Jingzi ZhangBao, Haiqing Li, Xiaoyang Li, Yongheng Huang, Min Wang, Chongbo Zhao, Jiahong Lu, Chuanzhen Lu, Yuxin Li, Chao Quan
We report the case of a patient who initially presented with fever, headache and seizure. MRI revealed a fluid attenuation inversion recovery (FLAIR) high-intensity lesion involving the right temporal, parietal and occipital cortex. Afterwards, the patient developed three recurrent episodes, manifested as brainstem encephalitis, optic neuritis and ADEM-like illness successively, indicating demyelination. Both of his serum anti-MOG and CSF anti-NMDAR antibodies were proved positive by transfected cell based assays...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29136091/clinical-presentation-and-prognosis-in-mog-antibody-disease-a-uk-study
#5
Maciej Jurynczyk, Silvia Messina, Mark R Woodhall, Naheed Raza, Rosie Everett, Adriana Roca-Fernandez, George Tackley, Shahd Hamid, Angela Sheard, Gavin Reynolds, Saleel Chandratre, Cheryl Hemingway, Anu Jacob, Angela Vincent, M Isabel Leite, Patrick Waters, Jacqueline Palace
A condition associated with an autoantibody against MOG has been recently recognized as a new inflammatory disease of the central nervous system, but the disease course and disability outcomes are largely unknown. In this study we investigated clinical characteristics of MOG-antibody disease on a large cohort of patients from the UK. We obtained demographic and clinical data on 252 UK patients positive for serum immunoglobulin G1 MOG antibodies as tested by the Autoimmune Neurology Group in Oxford. Disability outcomes and disease course were analysed in more detail in a cohort followed in the Neuromyelitis Optica Oxford Service (n = 75), and this included an incident cohort who were diagnosed at disease onset (n = 44)...
November 9, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29131884/seizures-and-encephalitis-in-myelin-oligodendrocyte-glycoprotein-igg-disease-vs-aquaporin-4-igg-disease
#6
Shahd H M Hamid, Dan Whittam, Mariyam Saviour, Amal Alorainy, Kerry Mutch, Samantha Linaker, Tom Solomon, Maneesh Bhojak, Mark Woodhall, Patrick Waters, Richard Appleton, Martin Duddy, Anu Jacob
Importance: Antibodies to myelin oligodendrocyte glycoprotein IgG (MOG-IgG) are increasingly detected in patients with non-multiple sclerosis-related demyelination, some of whom manifest a neuromyelitis optica (NMO) phenotype. Cortical involvement, encephalopathy, and seizures are rare in aquaporin 4 antibody (AQP4-IgG)-related NMO in the white European population. However, the authors encountered several patients with seizures associated with MOG-IgG disease. Objective: To compare incidence of seizures and encephalitis-like presentation, or both between AQP4-IgG-positive and MOG-IgG-positive patients...
November 13, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29114566/reversible-paraspinal-muscle-hyperintensity-in-anti-mog-antibody-associated-transverse-myelitis
#7
Lekha Pandit, Sharik Mustafa, Raghuraj Uppoor, Ichiro Nakashima, Toshiyuki Takahashi, Kimihiko Kaneko
No abstract text is available yet for this article.
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29101456/clinical-characteristics-of-myelin-oligodendrocyte-glycoprotein-seropositive-optic-neuritis-a-cohort-study-in-shanghai-china
#8
Guixian Zhao, Qian Chen, Yongheng Huang, Zhenxin Li, Xinghuai Sun, Ping Lu, S Yan, Min Wang, Guohong Tian
Qualitative and quantitative visual outcomes of Asian optic neuritis (ON) patients with seropositive myelin oligodendrocyte glycoprotein (MOG) antibodies remain unknown. We retrospectively evaluated a cohort of new-onset ON patients in Shanghai, China between January 2015 and December 2016. Serum MOG and aquaporin-4 (AQP4) antibodies were detected using cell-based assays, and patients were followed-up for at least 6 months. The clinical characteristics and optical coherence tomography (OCT) results were evaluated in the MOG-seropositive optic neuritis (MOG-ON), AQP4-seropositive (AQP4-ON), and double seronegative (Seronegative-ON) patients...
November 3, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29073350/understanding-the-antibody-repertoire-in-neuropsychiatric-systemic-lupus-erythematosus-and-neuromyelitis-optica-spectrum-disorders-do-they-share-common-targets
#9
Simone Mader, Venkatesh Jeganathan, Yoshiyuki Arinuma, Yuichiro Fujieda, Irena Dujmovic, Jelena Drulovic, Yuka Shimizu, Yuko Sakuma, Joel N H Stern, Cynthia Aranow, Meggan Mackay, Shinsuke Yasuda, Tatsuya Atsumi, Shunsei Hirohata, Betty Diamond
OBJECTIVE: DWEYS-IgG cross-reactive with DNA and the N-methyl-D-aspartate receptor subunits GluN2A/GluN2B has been associated with neuropsychiatric systemic lupus erythematosus (NPSLE). DWEYS-IgG has not been investigated in demyelinating NPSLE (dNPSLE) or in another demyelinating disorder, Neuromyelitis Optica Spectrum Disorder (NMOSD), which is also a disease of young women and associated with aquaporin-4 (AQP4) or myelin oligodendrocyte glycoprotein (MOG) antibodies. We investigated the frequency of these brain-reactive antibodies in NPSLE, dNPSLE and NMOSD...
October 26, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29070756/a-case-of-anti-mog-antibody-positive-multiphasic-disseminated-encephalomyelitis-co-occurring-with-unilateral-cerebral-cortical-encephalitis
#10
Naoya Fukushima, Miki Suzuki, Ryo Ogawa, Kitami Hayashi, Jun-Ichi Takanashi, Takashi Ohashi
A 20-year-old woman first developed acute disseminated encephalomyelitis (ADEM) at 11 years of age. At 17 years of age, she was hospitalized due to generalized seizure and diagnosed with encephalitis. Brain MRI revealed a FLAIR-hyperintense lesion in the unilateral cerebral cortex. At 18 years of age, serum anti-myelin oligodendrocyte glycoprotein (MOG) antibody was detected. At 20 years of age, she was admitted to our hospital, diagnosed with multifocal disseminated encephalomyelitis (MDEM). MDEM has been observed in patients that are seropositive for the anti-MOG antibody...
October 26, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29070750/a-case-of-recurrent-myelitis-associated-with-anti-myelin-oligodendrocyte-glycoprotein-antibody-that-developed-only-as-localized-short-spinal-cord-lesions
#11
Arifumi Matsumoto, Kimihiko Kaneko, Toshiyuki Takahashi, Ichiro Nakashima, Kinya Hisanaga, Isao Nagano
A 65-year-old man initially developed numbness and hypesthesia in the right shoulder and brachial regions that disappeared within several months. MRI revealed a small lesion extending to a vertebral segment in the right dorsal region of the cervical spinal cord at the vertebral height of C2/3. About 15 months later, the intermittent lancinating pain identical to the right trigeminal and occipital neuralgia with pain and hypesthesia distributed in the right C2-C4 dermatome regions appeared. MRI revealed a new oval lesion with gadolinium enhancement in the right dorsal region of the cervical spinal cord at the vertebral height of C1, which was thought to involve the posterior column and lower part of the spinal tract nucleus of the trigeminal nerve...
October 26, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29070051/human-antibodies-against-the-myelin-oligodendrocyte-glycoprotein-can-cause-complement-dependent-demyelination
#12
Patrick Peschl, Kathrin Schanda, Bleranda Zeka, Katherine Given, Denise Böhm, Klemens Ruprecht, Albert Saiz, Andreas Lutterotti, Kevin Rostásy, Romana Höftberger, Thomas Berger, Wendy Macklin, Hans Lassmann, Monika Bradl, Jeffrey L Bennett, Markus Reindl
BACKGROUND: Antibodies to the myelin oligodendrocyte glycoprotein (MOG) are associated with a subset of inflammatory demyelinating diseases of the central nervous system such as acute disseminated encephalomyelitis and neuromyelitis optica spectrum disorders. However, whether human MOG antibodies are pathogenic or an epiphenomenon is still not completely clear. Although MOG is highly conserved within mammals, previous findings showed that not all human MOG antibodies bind to rodent MOG...
October 25, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29064441/pattern-recognition-of-the-multiple-sclerosis-syndrome
#13
REVIEW
Rana K Zabad, Renee Stewart, Kathleen M Healey
During recent decades, the autoimmune disease neuromyelitis optica spectrum disorder (NMOSD), once broadly classified under the umbrella of multiple sclerosis (MS), has been extended to include autoimmune inflammatory conditions of the central nervous system (CNS), which are now diagnosable with serum serological tests. These antibody-mediated inflammatory diseases of the CNS share a clinical presentation to MS. A number of practical learning points emerge in this review, which is geared toward the pattern recognition of optic neuritis, transverse myelitis, brainstem/cerebellar and hemispheric tumefactive demyelinating lesion (TDL)-associated MS, aquaporin-4-antibody and myelin oligodendrocyte glycoprotein (MOG)-antibody NMOSD, overlap syndrome, and some yet-to-be-defined/classified demyelinating disease, all unspecifically labeled under MSsyndrome...
October 24, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29063242/clinical-spectrum-and-igg-subclass-analysis-of-anti-myelin-oligodendrocyte-glycoprotein-antibody-associated-syndromes-a-multicenter-study
#14
Sara Mariotto, Sergio Ferrari, Salvatore Monaco, Maria Donata Benedetti, Kathrin Schanda, Daniela Alberti, Alessia Farinazzo, Ruggero Capra, Chiara Mancinelli, Nicola De Rossi, Roberto Bombardi, Luigi Zuliani, Marco Zoccarato, Raffaella Tanel, Adriana Bonora, Marco Turatti, Massimiliano Calabrese, Alberto Polo, Antonino Pavone, Luisa Grazian, GianPietro Sechi, Elia Sechi, Daniele Urso, Rachele Delogu, Francesco Janes, Luciano Deotto, Morena Cadaldini, Maria Rachele Bianchi, Gaetano Cantalupo, Markus Reindl, Alberto Gajofatto
Anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) recently emerged as a potential biomarker in patients with inflammatory demyelinating diseases of the central nervous system. We here compare the clinical and laboratory findings observed in a cohort of MOG-Ab seropositive and seronegative cases and describe IgG subclass analysis results. Consecutive serum samples referred to Verona University Neuropathology Laboratory for aquaporin-4 (AQP4)-Ab and/or MOG-Ab testing were analysed between March 2014 and May 2017...
October 23, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29055448/a-case-of-mog-antibody-positive-bilateral-optic-neuritis-and-meningoganglionitis-following-a-genital-herpes-simplex-virus-infection
#15
Masataka Nakamura, Yuko Iwasaki, Toshiyuki Takahashi, Kimihiko Kaneko, Ichiro Nakashima, Takenobu Kunieda, Satoshi Kaneko, Hirofumi Kusaka
BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG) antibody-positive optic neuritis (ON) and myelitis are recognized as important differential diagnosis of aquaporin-4 (AQP4) antibody-positive neuromyelitis optica (NMO)/NMO spectrum disorder (NMOSD). Similar to NMO/NMOSD associated with AQP4 antibodies, preceding infections have been reported in patients with MOG antibody-positive ON. This is the first report of bilateral ON following a herpes simplex virus (HSV) infection associated with a positive MOG antibody...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29025172/-anti-myelin-oligodendrocyte-glycoprotein-antibodies-in-paediatric-patients-with-optic-neuritis
#16
Helmut Tegetmeyer, Andreas Merkenschlager
Background Myelin oligodendrocyte glycoprotein (MOG) is located on the surface of oligodendrocytes and myelin in the central nervous system. MOG-IgG is associated with acute disseminated encephalomyelitis (ADEM), relapsing and bilateral optic neuritis (NNO), and transverse myelitis (TM) in both paediatric and adult patients. The combination of NNO and TM or other inflammatory brain lesions is a typical feature of neuromyelitis optica spectrum disorders (NMO-SD) which are associated with specific pathogenic autoantibodies against the water channel aquaporin-4 (AQP4-IgG)...
October 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28991690/neuromyelitis-optica-spectrum-disorders-with-antibodies-to-myelin-oligodendrocyte-glycoprotein-or-aquaporin-4-clinical-and-paraclinical-characteristics-in-algerian-patients
#17
Melissa Bouzar, Smail Daoudi, Samira Hattab, Amel A Bouzar, Kumaran Deiva, Brigitte Wildemann, Markus Reindl, Sven Jarius
BACKGROUND: Neuromyelitis optica (NMO) is a severe autoimmune inflammatory disorder of the central nervous system. NMO and its abortive forms are referred to as NMO spectrum disorders (NMOSD). NMOSD are mostly associated with antibodies to aquaporin-4 (AQP4-IgG). However, recent studies have demonstrated antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) in a subset of patients. Data on NMOSD in North Africa are sparse. OBJECTIVE: To describe the frequency of MOG-IgG and AQP4-IgG among patients with optic neuritis (ON) and/or myelitis in Algeria as well as the clinical and paraclinical features associated with these antibodies...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28984163/epidemiology-of-nmosd-in-catalonia-influence-of-the-new-2015-criteria-in-incidence-and-prevalence-estimates
#18
Maria Sepúlveda, Marta Aldea, Domingo Escudero, Sara Llufriu, Georgina Arrambide, Susana Otero-Romero, J Sastre-Garriga, Lucía Romero-Pinel, Sergio Martínez-Yélamos, N Sola-Valls, Thais Armangué, Javier Sotoca, Antonio Escartín, René Robles-Cedeño, Lluís Ramió-Torrentà, Silvia Presas-Rodríguez, Cristina Ramo-Tello, Elvira Munteis, Raúl Pelayo, Laura Gubieras, Luis Brieva, Nicolau Ortiz, Mariona Hervás, Maria Alba Mañé-Martínez, Antonio Cano, Emili Vela, Mar Tintoré, Yolanda Blanco, Xavier Montalban, Francesc Graus, Albert Saiz
BACKGROUND: Population-based studies on neuromyelitis optica spectrum disorders (NMOSD) are limited, and it is unclear whether the rates have changed with the implementation of the new 2015 criteria. OBJECTIVES: To estimate the incidence and prevalence of NMOSD in Catalonia (Spain), using both the 2006 and the 2015 criteria. METHODS: In this clinic-based retrospective study, patients diagnosed with NMOSD between 2006 and 2015 were identified using multiple sources, including direct contact to all Catalan hospitals, identification of cases through the Catalan Health Surveillance System, and registry of antibodies to aquaporin-4 (AQP4-IgG) and myelin oligodendrocyte glycoprotein (MOG-IgG) in a reference laboratory...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28982346/mog-antibody-seropositivity-in-a-patient-with-encephalitis-beyond-the-classical-syndrome
#19
Sara Mariotto, Salvatore Monaco, Patrick Peschl, Ilaria Coledan, Romualdo Mazzi, Romana Höftberger, Markus Reindl, Sergio Ferrari
BACKGROUND: The presence of circulating anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) has been described in sera of patients with different inflammatory conditions of the central nervous system. In adults the core clinical feature is usually characterised by acute myelitis and/or optic neuritis. We here report an atypical case with serum and cerebrospinal fluid MOG-Abs and a clinical picture suggestive for acute encephalitis. CASE PRESENTATION: A 31-year-old Indian man presented with altered mental status, slight fever, and ataxia...
October 5, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28980518/a-population-based-prospective-study-of-optic-neuritis
#20
K Soelberg, S Jarius, Hpb Skejoe, H Engberg, J J Mehlsen, A C Nilsson, J S Madsen, M Reindl, B Wildemann, J Grauslund, K O Kyvik, T J Smith, S T Lillevang, F Paul, B G Weinshenker, N Asgari
BACKGROUND: Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management. OBJECTIVE: To estimate the incidence of acute ON and the rates of conversion to MS and antibody-mediated ON. METHOD: Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
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