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Michelle Le, Fiona E McNeill, Colin B Seymour, Andrej Rusin, Kevin Diamond, Andrew J Rainbow, James Murphy, Carmel E Mothersill
Radiation-induced biophotons are an electromagnetic form of bystander signalling. In human cells, biophoton signalling is capable of eliciting effects in non-irradiated bystander cells. However, the mechanisms by which the biophotons interact and act upon the bystander cells are not clearly understood. Mitochondrial energy production and ROS are known to be involved but the precise interactions are not known. To address this question, we have investigated the effect of biophoton emission upon the function of the complexes of oxidative phosphorylation (OXPHOS)...
February 7, 2018: Environmental Research
Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Beatrice Sacconi
Every body structure is wrapped in connective tissue or fascia, creating a structural continuity that gives form and function to every tissue and organ. The fascial tissue is uniformly distributed throughout the body, enveloping, interacting with and permeating blood vessels, nerves, viscera, meninges, bones and muscles, creating various layers at different depths and forming a tridimensional metabolic and mechanical matrix. This article reviews the literature on the emission of biophotons and adjustable sounds by the fascial system, because these biological changes could be a means of local and systemic cellular communication and become another assessment tool for manual (therapy) practitioners...
January 2018: J Evid Based Integr Med
Ulyana Shimanovich, Dorothea Pinotsi, Klimentiy Shimanovich, Na Yu, Sreenath Bolisetty, Jozef Adamcik, Raffaele Mezzenga, Jerome Charmet, Fritz Vollrath, Ehud Gazit, Christopher M Dobson, Gabriele Kaminski Schierle, Chris Holland, Clemens F Kaminski, Tuomas P J Knowles
Native silk fibroin (NSF) is a unique biomaterial with extraordinary mechanical and biochemical properties. These key characteristics are directly associated with the physical transformation of unstructured, soluble NSF into highly organized nano- and microscale fibrils rich in β-sheet content. Here, it is shown that this NSF fibrillation process is accompanied by the development of intrinsic fluorescence in the visible range, upon near-UV excitation, a phenomenon that has not been investigated in detail to date...
January 29, 2018: Macromolecular Bioscience
Meenaakshi Sundhari R P
Objective: The method to treating cancer that combines light and light-sensitive drugs to selectively destroy tumour cells without harming healthy tissue is called photodynamic therapy (PDT). It requires accurate data for light dose distribution, generated with scalable algorithms. One of the benchmark approaches involves Monte Carlo (MC) simulations. This gives an accurate assessment of light dose distribution, but is very demanding in computation time, which prevents routine application for treatment planning...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Kaikai Guo, Zibang Zhang, Shaowei Jiang, Jun Liao, Jingang Zhong, Yonina C Eldar, Guoan Zheng
Fluorescence imaging through a turbid layer holds great promise for various biophotonics applications. Conventional wavefront shaping techniques aim to create and scan a focus spot through the turbid layer. Finding the correct input wavefront without direct access to the target plane remains a critical challenge. In this paper, we explore a new strategy for imaging through turbid layer with a large field of view. In our setup, a fluorescence sample is sandwiched between two turbid layers. Instead of generating one focus spot via wavefront shaping, we use an unshaped beam to illuminate the turbid layer and generate an unknown speckle pattern at the target plane over a wide field of view...
January 1, 2018: Biomedical Optics Express
Jürgen Popp
No abstract text is available yet for this article.
January 2018: Journal of Biophotonics
Vaclav Prajzler, Kyungtaek Min, Sunghwan Kim, Pavla Nekvindova
Silk fibroin protein has been reinvented as a new optical material for biophotonic applications because of its optical transparency, biocompatibility, and easy fabrication process. It is used in various silk-based optical devices, which makes it desirable to investigate the optical properties of silk from diverse perspectives. This paper presents our investigation of the optical properties of silk fibroin, extracted from Bombyx mori cocoons. We have measured transmission spectra from the visible to near-infrared region and investigated waveguiding properties by the prism-coupling technique for five wavelengths (473...
January 11, 2018: Materials
Adam B Raff, Theo G Seiler, Gabriela Apiou-Sbirlea
The 'Bridging medicine and biomedical technology' special all-congress session took place for the first time at the OSA Biophotonics Congress: Optics in Life Sciences in 2017 ( The purpose was to identify key challenges the biomedical scientists in academia have to overcome to translate their discoveries into clinical practice through robust collaborations with industry and discuss best practices to facilitate and accelerate the process...
December 1, 2017: Biomedical Optics Express
Stephen A Boppart, J Quincy Brown, Camile S Farah, Esther Kho, Laura Marcu, Christobel M Saunders, Henricus J C M Sterenborg
The biannual International Conference on Biophotonics was recently held on April 30 to May 1, 2017, in Fremantle, Western Australia. This continuing conference series brought together key opinion leaders in biophotonics to present their latest results and, importantly, to participate in discussions on the future of the field and what opportunities exist when we collectively work together for using biophotonics for biological discovery and medical applications. One session in this conference, entitled "Tumor Margin Identification: Critiquing Technologies," challenged invited speakers and attendees to review and critique representative label-free optical imaging technologies and their application for intraoperative assessment and guidance in surgical oncology...
December 2017: Journal of Biomedical Optics
Aaron D Aguirre, Gabriela Apiou-Sbirlea, Darren Roblyer, Bruce J Tromberg
This guest editorial introduces the Special Section on Translational Biophotonics.
December 2017: Journal of Biomedical Optics
Laura Marcu, Stephen A Boppart, Mark R Hutchinson, Jürgen Popp, Brian C Wilson
The 5th International Conference on Biophotonics (ICOB) held April 30 to May 1, 2017, in Fremantle, Western Australia, brought together opinion leaders to discuss future directions for the field and opportunities to consider. The first session of the conference, "How to Set a Big Picture Biophotonics Agenda," was focused on setting the stage for developing a vision and strategies for translation and impact on society of biophotonic technologies. The invited speakers, panelists, and attendees engaged in discussions that focused on opportunities and promising applications for biophotonic techniques, challenges when working at the confluence of the physical and biological sciences, driving factors for advances of biophotonic technologies, and educational opportunities...
December 2017: Journal of Biomedical Optics
Daniel M Beswick, Arjun Kaushik, Dylan Beinart, Sarah McGarry, Ming Khoon Yew, Brendan F Kennedy, Peter Luke Santa Maria
The process of medical device innovation involves an iterative method that focuses on designing innovative, device-oriented solutions that address unmet clinical needs. This process has been applied to the field of biophotonics with many notable successes. Device innovation begins with identifying an unmet clinical need and evaluating this need through a variety of lenses, including currently existing solutions for the need, stakeholders who are interested in the need, and the market that will support an innovative solution...
December 2017: Journal of Biomedical Optics
Hua Shi, Qingming Luo
Biophotonics is a highly interdisciplinary field where physicists, chemists, biologists, physicians and engineers work together to solve the problems appearing in biology and medicine. In China, the Biophotonics discipline is often referred to as Biomedical Photonics, under the first-level disciplines Biomedical Engineering or Optical Engineering, and was initiated in the late 1990s. Over the past 20 years, biophotonics research in China expanded extraordinarily and has reached the frontiers of the world-level sciences...
December 2017: Journal of Biophotonics
Nirosha J Murugan, Nicolas Rouleau, Lukasz M Karbowski, Michael A Persinger
Early detection is a critically important factor when successfully diagnosing and treating cancer. Whereas contemporary molecular techniques are capable of identifying biomarkers associated with cancer, surgical interventions are required to biopsy tissue. The common imaging alternative, positron-emission tomography (PET), involves the use of nuclear material which poses some risks. Novel, non-invasive techniques to assess the degree to which tissues express malignant properties are now needed. Recent developments in biophoton research have made it possible to discriminate cancerous cells from normal cells both in vitro and in vivo...
March 2018: Biochemistry and Biophysics Reports
Hui Li, Lei Xu, Guanying Chen
The ability to synthesize upconversion nanocrystals (UCNCs) with tailored upconversion luminescence and controlled size is of great importance for biophotonic applications. However, until now, limited success has been met to prepare bright, ultrasmall, and monodispersed β-NaYF₄:Yb3+/Er3+ UCNCs. In this work, we report on a synthetic method to produce monodisperse hexagonal NaYF₄:Yb3+/Er3+ nanocrystals of ultrasmall size (5.4 nm) through a precise control of the reaction temperature and the ratio of Na⁺/Ln3+/F-...
December 1, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Andreas Nikolis, Stéphane Fauverghe, Giovanni Scapagnini, Dimitrios Sotiriadis, George Kontochristopoulos, Athanasios Petridis, Dimitrios Rigopoulos, Clio Dessinioti, Konstantinos Kalokasidis, Christina Antoniou
A variety of laser/light-based devices have been reported to be effective for the treatment of acne, yet no long-term data on efficacy and safety have been published. A first 12-week clinical trial ("Main trial") recently demonstrated that the KLOX BioPhotonic System, an LED blue light device using photo-converter chromophores, can significantly improve moderate and severe facial acne vulgaris with an excellent safety profile. This Extension trial followed the Main trial, using the same BioPhotonic System, with the same dose and instructions for use, on patients having already completed treatment in the Main trial...
November 20, 2017: International Journal of Dermatology
A T Press, M J Butans, T P Haider, C Weber, S Neugebauer, M Kiehntopf, U S Schubert, M G Clemens, M Bauer, A Kortgen
Simultaneous assessment of excretory liver and kidney function is still an unmet need in experimental stress models as well as in critical care. The aim of the study was to characterize two polymethine-dyes potentially suitable for this purpose in vivo. Plasma disappearance rate and elimination measurements of simultaneously injected fluorescent dyes DY-780 (hepato-biliary elimination) and DY-654(renal elimination) were conducted using catheter techniques and intravital microscopy in animals subjected to different organ injuries, i...
November 13, 2017: Scientific Reports
Tobias Tiess, Martin Becker, Manfred Rothhardt, Hartmut Bartelt, Matthias Jäger
We present a fiber-integrated laser enabling independent tuning of two emission wavelengths with a synchronized pulsed emission. The discrete tuning concept comprises a theta cavity fiber laser (TCFL), a fiber Bragg grating (FBG) array as a versatile spectral filter, facilitating tailored tuning ranges, and optical gating to control the emission spectrum. A novel electrical driving scheme uniquely enables independently tunable multi-wavelength emission from a single laser oscillator. Tunable dual-wavelength emission is experimentally investigated with a ytterbium (Yb)-doped TCFL using an FBG array with 11 gratings...
October 30, 2017: Optics Express
Radwanul H Siddique, Yidenekachew J Donie, Guillaume Gomard, Sisir Yalamanchili, Tsvetelina Merdzhanova, Uli Lemmer, Hendrik Hölscher
The wings of the black butterfly, Pachliopta aristolochiae, are covered by micro- and nanostructured scales that harvest sunlight over a wide spectral and angular range. Considering that these properties are particularly attractive for photovoltaic applications, we analyze the contribution of these micro- and nanostructures, focusing on the structural disorder observed in the wing scales. In addition to microspectroscopy experiments, we conduct three-dimensional optical simulations of the exact scale structure...
October 2017: Science Advances
Liana Lucchetti, Tommaso P Fraccia, Fabrizio Ciciulla, Francesco Simoni, Tommaso Bellini
We report the experimental evidence of nonlinear optical response in DNA lyotropic nematic liquid crystals. Pump-probe experiments indicate that the non-linearity is remarkably large. Quantitative assessment of the non-linear optical coefficient by transient optical grating demonstrates that the response is of the same order of the well-known Giant Optical Nonlinearity (GON) of thermotropic nematics. These results represent a further incentive to the current investigation of potential applications of DNA in biophotonics...
October 16, 2017: Optics Express
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