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Na Dong, Rolando Berlinguer-Palmini, Ahmed Soltan, Nikhil Ponon, Anthony O'Neil, Andrew Travelyan, Pleun Maaskant, Patrick Degenaar, Xiaohan Sun
Implantable photonic probes are of increasing interest to the field of biophotonics and in particular, optogenetic neural stimulation. Active probes with onboard light emissive elements allow for electronic multiplexing and can be manufactured through existing microelectronics methods. However, as the optogenetics field moves towards clinical practice, an important question arises as to whether such probes will cause excessive thermal heating of the surrounding tissue. Light emitting diodes typically produce more heat than light...
March 30, 2018: Journal of Biophotonics
Yu Chen, Minghuai Yu, Shuai Ye, Jun Song, Junle Qu
Lead halide perovskite nanocrystals with efficient two-photon absorption and ease of achieving population inversion have been recognized as good candidates to achieve frequency up-conversion for biophotonics applications, but suffer from the limitation of the miniaturization of the device and its corresponding poor stability when exposed to atmospheric moisture. Here we demonstrate the miniaturization of plasmonic nanolasers via embedding perovskite quantum dots (QDs) in rationally designed dual-mesoporous silica with gold nanocore...
March 28, 2018: Nanoscale
Nassima Chouaki-Benmansour, Kilian Ruminski, Anne-Marie Sartre, Marie-Claire Phelipot, Audrey Salles, Elise Bergot, Ambroise Wu, Gaëtan Chicanne, Mathieu Fallet, Sophie Brustlein, Cyrille Billaudeau, Anthony Formisano, Sébastien Mailfert, Bernard Payrastre, Didier Marguet, Sophie Brasselet, Yannick Hamon, Hai-Tao He
Phosphoinositides (PIs) play important roles in numerous membrane-based cellular activities. However, their involvement in the mechanism of T cell receptor (TCR) signal transduction across the plasma membrane (PM) is poorly defined. Here, we investigate their role, and in particular that of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] in TCR PM dynamics and activity in a mouse T-cell hybridoma upon ectopic expression of a PM-localized inositol polyphosphate-5-phosphatase (Inp54p). We observed that dephosphorylation of PI(4,5)P2 by the phosphatase increased the TCR/CD3 complex PM lateral mobility prior stimulation...
March 21, 2018: Scientific Reports
Lu Han, Shunai Che
Triply periodic minimal surface structures and related geometries are widely identified in many natural systems, such as biological membranes and biophotonic structures in butterfly-wing scales. Inspired by their marvelous and highly symmetrical structures and optimized physical properties, these structures have sparked immense interest for creating novel materials by extracting the design from nature. Significant progress has been made to understand these biological structures and fabricate artificial materials by top-down and bottom-up approaches for numerous applications in chemistry and materials science...
March 15, 2018: Advanced Materials
Paul Campagnola, Daniel Cote, Francesco Pavone, Peter Reece, Vivek J Srinivasan, Tomasz Tkaczyk, Giovanni Volpe
We introduce the feature issue on the Optics in the Life Sciences Congress held on April 2-5, 2017 in San Diego, CA. The Congress consisted of 5 topical symposia: (i) Bio-optics Design and Application; (ii) Novel Techniques in Microscopy; (iii) Optical Molecular Probes, Imaging and Drug Delivery; (iv) Optical Trapping Applications; and (v) Optics and the Brain. These separate symposia also held joint sessions of common interest. The following highlights some of the topics from the Congress.
March 1, 2018: Biomedical Optics Express
(no author information available yet)
This publisher's note explains the change in citation data for 3 articles.
March 2018: Journal of Biomedical Optics
S U Rahman, R C Mosca, S Govindool Reddy, S C Nunez, S Andreana, T S Mang, P R Arany
This narrative review on the use of biophotonics therapies for management of oral diseases is written as a tribute to Prof. Crispian Scully. His seminal contributions to the field are highlighted by the detailed, comprehensive description of clinical presentations of oral diseases. This has enabled a more thorough, fundamental understanding of many of these pathologies by research from his group as well as inspired mechanistic investigations in many groups globally. In the same vein, a major emphasis of this narrative review is to focus on the evidence from human case reports rather than in vitro or in vivo animal studies that showcases the growing and broad impact of biophotonics therapies...
March 2018: Oral Diseases
Carmel Mothersill, Richard Smith, Jiaxi Wang, Andrej Rusin, Cris Fernandez-Palomo, Jennifer Fazzari, Colin Seymour
The phenomenon by which irradiated organisms including cells in vitro communicate with unirradiated neighbors is well established in biology as the radiation-induced bystander effect (RIBE). Generally, the purpose of this communication is thought to be protective and adaptive, reflecting a highly conserved evolutionary mechanism enabling rapid adjustment to stressors in the environment. Stressors known to induce the effect were recently shown to include chemicals and even pathological agents. The mechanism is unknown but our group has evidence that physical signals such as biophotons acting on cellular photoreceptors may be implicated...
January 2018: Dose-response: a Publication of International Hormesis Society
Michelle Le, Fiona E McNeill, Colin B Seymour, Andrej Rusin, Kevin Diamond, Andrew J Rainbow, James Murphy, Carmel E Mothersill
Radiation-induced biophotons are an electromagnetic form of bystander signalling. In human cells, biophoton signalling is capable of eliciting effects in non-irradiated bystander cells. However, the mechanisms by which the biophotons interact and act upon the bystander cells are not clearly understood. Mitochondrial energy production and ROS are known to be involved but the precise interactions are not known. To address this question, we have investigated the effect of biophoton emission upon the function of the complexes of oxidative phosphorylation (OXPHOS)...
February 7, 2018: Environmental Research
Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Beatrice Sacconi
Every body structure is wrapped in connective tissue or fascia, creating a structural continuity that gives form and function to every tissue and organ. The fascial tissue is uniformly distributed throughout the body, enveloping, interacting with and permeating blood vessels, nerves, viscera, meninges, bones and muscles, creating various layers at different depths and forming a tridimensional metabolic and mechanical matrix. This article reviews the literature on the emission of biophotons and adjustable sounds by the fascial system, because these biological changes could be a means of local and systemic cellular communication and become another assessment tool for manual (therapy) practitioners...
January 2018: Journal of evidence-based integrative medicine
Ulyana Shimanovich, Dorothea Pinotsi, Klimentiy Shimanovich, Na Yu, Sreenath Bolisetty, Jozef Adamcik, Raffaele Mezzenga, Jerome Charmet, Fritz Vollrath, Ehud Gazit, Christopher M Dobson, Gabriele Kaminski Schierle, Chris Holland, Clemens F Kaminski, Tuomas P J Knowles
Native silk fibroin (NSF) is a unique biomaterial with extraordinary mechanical and biochemical properties. These key characteristics are directly associated with the physical transformation of unstructured, soluble NSF into highly organized nano- and microscale fibrils rich in β-sheet content. Here, it is shown that this NSF fibrillation process is accompanied by the development of intrinsic fluorescence in the visible range, upon near-UV excitation, a phenomenon that has not been investigated in detail to date...
January 29, 2018: Macromolecular Bioscience
Meenaakshi Sundhari R P
Objective: The method to treating cancer that combines light and light-sensitive drugs to selectively destroy tumour cells without harming healthy tissue is called photodynamic therapy (PDT). It requires accurate data for light dose distribution, generated with scalable algorithms. One of the benchmark approaches involves Monte Carlo (MC) simulations. This gives an accurate assessment of light dose distribution, but is very demanding in computation time, which prevents routine application for treatment planning...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Kaikai Guo, Zibang Zhang, Shaowei Jiang, Jun Liao, Jingang Zhong, Yonina C Eldar, Guoan Zheng
Fluorescence imaging through a turbid layer holds great promise for various biophotonics applications. Conventional wavefront shaping techniques aim to create and scan a focus spot through the turbid layer. Finding the correct input wavefront without direct access to the target plane remains a critical challenge. In this paper, we explore a new strategy for imaging through turbid layer with a large field of view. In our setup, a fluorescence sample is sandwiched between two turbid layers. Instead of generating one focus spot via wavefront shaping, we use an unshaped beam to illuminate the turbid layer and generate an unknown speckle pattern at the target plane over a wide field of view...
January 1, 2018: Biomedical Optics Express
Jürgen Popp
No abstract text is available yet for this article.
January 2018: Journal of Biophotonics
Vaclav Prajzler, Kyungtaek Min, Sunghwan Kim, Pavla Nekvindova
Silk fibroin protein has been reinvented as a new optical material for biophotonic applications because of its optical transparency, biocompatibility, and easy fabrication process. It is used in various silk-based optical devices, which makes it desirable to investigate the optical properties of silk from diverse perspectives. This paper presents our investigation of the optical properties of silk fibroin, extracted from Bombyx mori cocoons. We have measured transmission spectra from the visible to near-infrared region and investigated waveguiding properties by the prism-coupling technique for five wavelengths (473...
January 11, 2018: Materials
Adam B Raff, Theo G Seiler, Gabriela Apiou-Sbirlea
The 'Bridging medicine and biomedical technology' special all-congress session took place for the first time at the OSA Biophotonics Congress: Optics in Life Sciences in 2017 ( The purpose was to identify key challenges the biomedical scientists in academia have to overcome to translate their discoveries into clinical practice through robust collaborations with industry and discuss best practices to facilitate and accelerate the process...
December 1, 2017: Biomedical Optics Express
Stephen A Boppart, J Quincy Brown, Camile S Farah, Esther Kho, Laura Marcu, Christobel M Saunders, Henricus J C M Sterenborg
The biannual International Conference on Biophotonics was recently held on April 30 to May 1, 2017, in Fremantle, Western Australia. This continuing conference series brought together key opinion leaders in biophotonics to present their latest results and, importantly, to participate in discussions on the future of the field and what opportunities exist when we collectively work together for using biophotonics for biological discovery and medical applications. One session in this conference, entitled "Tumor Margin Identification: Critiquing Technologies," challenged invited speakers and attendees to review and critique representative label-free optical imaging technologies and their application for intraoperative assessment and guidance in surgical oncology...
December 2017: Journal of Biomedical Optics
Aaron D Aguirre, Gabriela Apiou-Sbirlea, Darren Roblyer, Bruce J Tromberg
This guest editorial introduces the Special Section on Translational Biophotonics.
December 2017: Journal of Biomedical Optics
Laura Marcu, Stephen A Boppart, Mark R Hutchinson, Jürgen Popp, Brian C Wilson
The 5th International Conference on Biophotonics (ICOB) held April 30 to May 1, 2017, in Fremantle, Western Australia, brought together opinion leaders to discuss future directions for the field and opportunities to consider. The first session of the conference, "How to Set a Big Picture Biophotonics Agenda," was focused on setting the stage for developing a vision and strategies for translation and impact on society of biophotonic technologies. The invited speakers, panelists, and attendees engaged in discussions that focused on opportunities and promising applications for biophotonic techniques, challenges when working at the confluence of the physical and biological sciences, driving factors for advances of biophotonic technologies, and educational opportunities...
December 2017: Journal of Biomedical Optics
Daniel M Beswick, Arjun Kaushik, Dylan Beinart, Sarah McGarry, Ming Khoon Yew, Brendan F Kennedy, Peter Luke Santa Maria
The process of medical device innovation involves an iterative method that focuses on designing innovative, device-oriented solutions that address unmet clinical needs. This process has been applied to the field of biophotonics with many notable successes. Device innovation begins with identifying an unmet clinical need and evaluating this need through a variety of lenses, including currently existing solutions for the need, stakeholders who are interested in the need, and the market that will support an innovative solution...
December 2017: Journal of Biomedical Optics
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