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https://www.readbyqxmd.com/read/28542707/-urinary-tract-infection-requiem-for-a-heavyweight
#1
Thomas E Finucane
"Urinary tract infection" ("UTI") is an ambiguous, expansive, overused diagnosis that can lead to marked, harmful antibiotic overtreatment. "Significant bacteriuria," central to most definitions of "UTI," has little significance in identifying individuals who will benefit from treatment. "Urinary symptoms" are similarly uninformative. Neither criterion is well defined. Bacteriuria and symptoms remit and recur spontaneously. Treatment is standard for acute uncomplicated cystitis and common for asymptomatic bacteriuria, but definite benefits are few...
May 19, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28542078/a-population-level-investigation-of-cancer-clinical-trials-participation-in-a-uk-region
#2
Conan B Donnelly, Amy C Wotherspoon, Melanie Morris, Richard H Wilson, Jingwen J Chen, Victoria Cairnduff, Eileen Morgan, Amy Devlin, Anna T Gavin
The aim of this study was to document cancer trial participation since establishment of the Northern Ireland Cancer Trials Network and investigate population and disease factors associated with trial participation. An independent cohort of over 51 000 cancer patients from the Northern Ireland Cancer Registry covering the same population (2007-2012) was linked to a database of 1316 interventional cancer trial participants in a UK region. The primary outcome measure was participation in an intervention clinical trial...
May 24, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28541397/prevalence-and-co-occurrence-of-geriatric-syndromes-in-people-aged-75-years-and-older-in-france-results-from-the-bordeaux-three-city-study
#3
Maturin Tabue-Teguo, Leslie Grasset, José Alberto Avila-Funes, Robin Genuer, Cecile Proust-Lima, Karine Péres, Catherine Féart, Hélène Amieva, Magali González-Colaço Harmand, Catherine Helmer, Nathalie Salles, Muriel Rainfray, Jean François Dartigues
Background: Geriatric syndromes (GSs) are often the result of cumulative insults to multiple organ systems and are considered common in older adults. However, their frequency and co-occurrence are not well known in the elderly population. This study aimed to determine the prevalence of several GSs and to analyze the co-occurrence of these syndromes in a general population of elderly individuals. Methods: A cross-sectional analysis of 630 adults aged 75 years or older participating in the 10-year follow-up of the Bordeaux sample of the French Three-City Study was conducted...
May 24, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28539885/intranasal-insulin-prevents-anesthesia-induced-cognitive-impairment-and-chronic-neurobehavioral-changes
#4
Yanxing Chen, Chun-Ling Dai, Zhe Wu, Khalid Iqbal, Fei Liu, Baorong Zhang, Cheng-Xin Gong
General anesthesia increases the risk for cognitive impairment post operation, especially in the elderly and vulnerable individuals. Recent animal studies on the impact of anesthesia on postoperative cognitive impairment have provided some valuable insights, but much remains to be understood. Here, by using mice of various ages and conditions, we found that anesthesia with propofol and sevoflurane caused significant deficits in spatial learning and memory, as tested using Morris Water Maze (MWM) 2-6 days after anesthesia exposure, in aged (17-18 months old) wild-type (WT) mice and in adult (7-8 months old) 3xTg-AD mice (a triple transgenic mouse model of Alzheimer's disease (AD)), but not in adult WT mice...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28539865/gastroesophageal-reflux-disease-prevalence-among-school-teachers-of-saudi-arabia-and-its-impact-on-their-daily-life-activities
#5
Abdulrahman Mohammed Altwigry, Majed Saud Almutairi, Masood Ahmed
BACKGROUND: Gastroesophageal reflux disease (GERD) is the most common upper gastrointestinal disorder encountered in the elderly patient. It is highly prevalent worldwide with a prevalence of 10-20% in the western world. The health-related quality of life (HRQL) is lower in individuals with GERD than in the general population and is comparable to that in individuals with other chronic diseases. It has a considerable impact on the quality of the patient's life through its symptoms and economically by following consultation procedures and medical care...
April 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28539380/sarcopenic-obesity-weight-loss-and-mortality-the-english-longitudinal-study-of-ageing
#6
Mark Hamer, Gary O'Donovan
Background: Age-related sarcopenia describes the loss of muscle strength and often accompanies an increase in adiposity in the elderly.Objective: We examined the association of sarcopenic obesity and changes in muscle strength and weight with the risk of mortality.Design: Participants (n = 6864) were community-dwelling men and women (45.6% men; 54.4% women; mean ± SD age: 66.2 ± 9.5 y) from the English Longitudinal Study of Ageing. Handgrip strength and body mass index (BMI; in kg/m(2)) were measured at baseline and at a 4-y follow-up...
May 24, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28539293/-comparison-of-risk-factors-for-serrated-polyps-and-conventional-adenoma-and-the-suitable-age-to-start-colorectal-cancer-screening
#7
Qian Dai, Jiang Liu, Mu-Xiao Zhong, Wei Zhu, Ya-Li Zhang
OBJECTIVE: To compare the risk factors associated with serrated polyps (SPs) and conventional adenoma (CA). METHODS: One hundred and three healthy control subjects, 100 patients with pathologically confirmed SPs and 115 with CA were randomly selected from individuals undergoing colonoscopy in Nanfang Hospital from 2012 to 2015. The demographic and clinical data were collected from the subjects, including age, gender, height, weight, hypertension, diabetes, smoking status, alcohol use, family history of colorectal cancer (CRC) and blood lipids...
May 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28539174/drug-metabolism-in-the-elderly-a-multifactorial-problem
#8
REVIEW
R H Waring, R M Harris, S C Mitchell
Whether or not an individual's drug metabolising capacity declines with advancing age is a vexing question. There is no clear evidence that drug metabolism itself ('the biologically-assisted chemical alteration of the administered parent molecule') is less efficient in healthy old age than at younger ages, whereas a decreased capacity may be associated with ill-health and frailty. However, elderly individuals do show a reduced enzyme induction capability and are less able to tolerate overdoses. It appears that the majority of deleterious clinical outcomes related to drug therapy in an elderly (usually ill or frail) population may be ascribed to various anatomical and physiological age-related changes...
June 2017: Maturitas
https://www.readbyqxmd.com/read/28539133/gender-differences-in-the-trajectories-and-the-risk-factors-of-depressive-symptoms-in-later-life
#9
Jiae Lee, Soong-Nang Jang, Sung-Il Cho
BACKGROUND: The present study investigated changes in the trajectories of depressive symptoms in the elderly and attempted to identify risk factors that influence these changes according to gender. METHODS: All data were obtained from a subsample of subjects who participated in the Korean Longitudinal Study of Ageing between 2006 and 2012; 3,667 individuals (1,566 men and 2,101 women) aged 60 years and older were included in the present study. A group-based trajectory model was employed to determine the appropriate number of groups and to observe changes in depressive symptoms according to research year...
May 25, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28538964/effect-of-a-modified-hospital-elder-life-program-on-delirium-and-length-of-hospital-stay-in-patients-undergoing-abdominal-surgery-a-cluster-randomized-clinical-trial
#10
Cheryl Chia-Hui Chen, Hsiu-Ching Li, Jin-Tung Liang, I-Rue Lai, Jerry Dwi Trijoyo Purnomo, Yi-Ting Yang, Been-Ren Lin, John Huang, Ching-Yao Yang, Yu-Wen Tien, Chiung-Nien Chen, Ming-Tsan Lin, Guan-Hua Huang, Sharon K Inouye
Importance: Older patients undergoing abdominal surgery commonly experience preventable delirium, which extends their hospital length of stay (LOS). Objective: To examine whether a modified Hospital Elder Life Program (mHELP) reduces incident delirium and LOS in older patients undergoing abdominal surgery. Design, Setting, and Participants: This cluster randomized clinical trial of 577 eligible patients enrolled 377 older patients (≥65 years of age) undergoing gastrectomy, pancreaticoduodenectomy, and colectomy at a 2000-bed urban medical center in Taipei, Taiwan, from August 1, 2009, through October 31, 2012...
May 24, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28538826/functional-change-in-the-pattern-of-swallowing-through-the-performance-of-orofacial-exercises
#11
Irina Claudia Fernandes Alves, Claudia Regina Furquim de Andrade
Purpose: The objective was to determine if there was functional improvement of swallowing pattern in subjects identified with risk of oropharyngeal dysphagia after four weeks of specific oropharyngeal exercises. These exercises have pre-determined intensity and duration. Methods: It is a longitudinal study of functional effect, determined by initial and final comparative measures. Participants were adults and elderly, selected in a period of 24 months. A total of 68 participants were included...
May 22, 2017: CoDAS
https://www.readbyqxmd.com/read/28538797/-evaluation-of-municipal-administration-of-healthcare-actions-for-the-elderly
#12
Keila Cristina Rausch Pereira, Josimari Telino de Lacerda, Sonia Natal
Aging individuals can experience frailty and loss of independence and autonomy. Healthcare for the elderly should help them recover their health and maintain their autonomy, in keeping with the Brazilian Statute of the Elderly and underlying policies in the Brazilian Unified National Health System. Based on a multiple case study, the objective was to assess the capacity of municipal administration to provide healthcare for the elderly. The assessment was oriented by an evaluative model validated by experts in administration and evaluation, with 16 indicators analyzing political, organizational, technical, and operational factors...
May 18, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28537769/the-ksr2-rs7973260-polymorphism-is-associated-with-metabolic-phenotypes-but-not-psychological-phenotypes-in-chinese-elders
#13
Yong Wang, Teng Ma, Yin-Sheng Zhu, Xue-Feng Chu, Shun Yao, Hong-Fei Wang, Jian Cai, Xiao-Feng Wang, Xiao-Yan Jiang
OBJECTIVE: To examine the associations between genetic variants KSR2 (kinase suppressor of RAS)-rs7973260, RAPGEF6 (guanine nucleotide exchange factor 6)-rs3756290, LOC105377703-rs4481363, and subjective well-being (SWB) and depressive symptoms (DSs) in Chinese elders, which were recently associated in a genome-wide association study conducted in Caucasians. The pleiotropic effects of KSR2-rs7973260 on metabolic phenotypes were also explored. MATERIALS AND METHODS: We used data of 1788 older individuals aged 70-84 years from the aging arm of the Rugao Longevity and Aging Study, a population-based cohort study conducted in the Jiangsu province of China...
May 24, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28537254/large-scale-meta-analysis-characterizes-genetic-architecture-for-common-psoriasis-associated-variants
#14
Lam C Tsoi, Philip E Stuart, Chao Tian, Johann E Gudjonsson, Sayantan Das, Matthew Zawistowski, Eva Ellinghaus, Jonathan N Barker, Vinod Chandran, Nick Dand, Kristina Callis Duffin, Charlotta Enerbäck, Tõnu Esko, Andre Franke, Dafna D Gladman, Per Hoffmann, Külli Kingo, Sulev Kõks, Gerald G Krueger, Henry W Lim, Andres Metspalu, Ulrich Mrowietz, Sören Mucha, Proton Rahman, Andre Reis, Trilokraj Tejasvi, Richard Trembath, John J Voorhees, Stephan Weidinger, Michael Weichenthal, Xiaoquan Wen, Nicholas Eriksson, Hyun M Kang, David A Hinds, Rajan P Nair, Gonçalo R Abecasis, James T Elder
Psoriasis is a complex disease of skin with a prevalence of about 2%. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for psoriasis to date, including data from eight different Caucasian cohorts, with a combined effective sample size >39,000 individuals. We identified 16 additional psoriasis susceptibility loci achieving genome-wide significance, increasing the number of identified loci to 63 for European-origin individuals. Functional analysis highlighted the roles of interferon signalling and the NFκB cascade, and we showed that the psoriasis signals are enriched in regulatory elements from different T cells (CD8(+) T-cells and CD4(+) T-cells including TH0, TH1 and TH17)...
May 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28534471/management-of-acetabular-fractures-in-the-geriatric-patient
#15
Marc Hanschen, Sebastian Pesch, Stefan Huber-Wagner, Peter Biberthaler
INTRODUCTION: Open reduction and internal fixation (ORIF) is standard care for most acetabular fractures. With increasing numbers of acetabular fractures in the elderly, the risk of revision surgery and conversion to total hip replacement (THR) is increasing. Alarmingly, about 20-25% of acetabular fractures in the elderly following ORIF needed revision and conversion to delayed THR. METHODS: Recently, prognostic factors have been identified, which correlate with an increased risk of worse outcomes following ORIF of acetabular fractures in the elderly patient...
2017: SICOT-J
https://www.readbyqxmd.com/read/28534210/association-study-of-estrogen-receptor-alpha-gene-polymorphisms-with-bone-mass-assessed-by-quantitative-ultrasound-in-young-adults
#16
María Correa-Rodriguez, Jacqueline Schmidt-RioValle, Blanca Rueda-Medina
Different genetic variants in estrogen receptor alpha (ESR1) have been shown to influence bone phenotypes including quantitative bone ultrasound in elderly. We aimed to investigate the role of ESR1 polymorphisms in bone mass assessed by calcaneal quantitative ultrasound (QUS) in a population of young adults. The study sample consisted of 466 healthy individuals of Caucasian ancestry (315 females and 152 males) aged 18 and 25 years (median age 20.39 ± 2.70). Six ESR1 polymorphisms (rs302033, rs2982552, rs2982575, rs2504063, rs2234693-PvuII and rs9340799-XbaI) were selected as genetic markers and genotyped...
May 22, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28533731/effect-of-loss-of-teeth-and-its-association-with-general-quality-of-life-using-geriatric-oral-health-assessment-index-gohai-among-older-individuals-residing-in-rural-areas
#17
Vinaya Kundapur, Rakshith Hegde, Manoj Shetty, Sunil Mankar, Mohammed Hilal, Hari Prasad A
The development of measures for assessing oral health status is essential to the evolution and maturation of a scientific knowledge based in geriatric dentistry. Their development as branches of clinical care depends in part as ability to demonstrate an effective grasp of the problems of elderly and their solutions. Any strategy for altering the health status of elderly requires a technology for first assessing that health status and then detecting increments of progress. Development of geriatric oral health assessment index (GOHAI) is a self reported measure designed to assess the oral health problems of older individuals...
March 2017: International Journal of Biomedical Science: IJBS
https://www.readbyqxmd.com/read/28532728/the-meaning-of-comfort-to-elderly-individuals-living-in-long-term-care-hospitals
#18
Eun-Ha Kim, Kye-Ha Kim
No abstract text is available yet for this article.
June 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28532453/impact-of-legumes-and-plant-proteins-consumption-on-cognitive-performances-in-the-elderly
#19
Elisa Mazza, Antonietta Fava, Yvelise Ferro, Marta Moraca, Stefania Rotundo, Carmela Colica, Francesco Provenzano, Rosa Terracciano, Marta Greco, Daniela Foti, Elio Gulletta, Diego Russo, Domenico Bosco, Arturo Pujia, Tiziana Montalcini
BACKGROUND: Numerous studies have investigated the role of the dietary factors in the prevention of cognitive decline but the short-term effects of foods choice on cognitive performances in the elderly are poorly explored. Our aim was to investigate the choice of foods among elderly Italian individuals and the association with cognitive function. METHODS: In this longitudinal study, the participants were 214 individuals aged ≥65 years with a score >20 at the Mini Mental State Examination...
May 22, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28531243/increased-postural-sway-during-quiet-stance-as-a-risk-factor-for-prospective-falls-in-community-dwelling-elderly-individuals
#20
Jonas Johansson, Anna Nordström, Yngve Gustafson, Göran Westling, Peter Nordström
Objective: fall-related injuries constitute major health risks in older individuals, and these risks are projected to increase in parallel with increasing human longevity. Impaired postural stability is a potential risk factor related to falls, although the evidence is inconclusive, partly due to the lack of prospective studies. This study aimed to investigate how objective measures of postural sway predict incident falls. Design, setting and participants: this prospectively observational study included 1,877 community-dwelling individuals aged 70 years who participated in the Healthy Ageing Initiative between June 2012 and December 2015...
May 22, 2017: Age and Ageing
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