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https://www.readbyqxmd.com/read/28734139/%C3%AE-nfluenza-a-h3n2-genetic-variants-in-vaccinated-patients-in-northern-greece
#1
A Melidou, G Gioula, M Exindari, E Ioannou, K Gkolfinopoulou, T Georgakopoulou, S Tsiodras, A Papa
BACKGROUND: Influenza A(H3N2) viruses predominated during the influenza 2016/2017 season and showed extensive genetic diversification. A high vaccination failure rate was noticed during the 2016/17 season in Greece, especially among the elderly. OBJECTIVES: The scope of the study was to investigate the genetic characteristics of A(H3N2) circulating viruses and viruses detected in vaccinated patients. STUDY DESIGN: Virus samples originated from vaccinated and unvaccinated patients, obtained at the National Influenza Centre for northern Greece...
July 14, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28732435/the-effect-of-oral-levamisole-co-administration-on-the-level-of-immune-response-to-hepatitis-b-vaccine-in-healthy-individuals-a-randomized-clinical-trial
#2
Mousalreza Hosseini, Payman Shalchiantabrizi, Maliheh Dadgarmoghaddam, Saeideh Ahmady-Simab, Azizollah Behjati, Masoumeh Salari
Despite its proven efficacy, the hepatitis B vaccine requires improvements in immune enhancement and durability, especially in the elderly. Levamisole, an immune modulator, has been tested as an adjuvant to hepatitis B vaccine in several studies in immune-compromised populations. However, we aimed to evaluate the effect of levamisole on the immune response to hepatitis B vaccine in healthy subjects. In this randomized clinical trial, healthy family members of chronic hepatitis B patients were given twenty-microgram intramuscular injections of hepatitis B vaccine at 0, 1, and 6 months and 50 miligrams of oral  levamisole twice a day for two weeks with every vaccination dose...
June 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28732235/medication-takeovers-covert-druggings-and-behavioral-control-in-alzheimer-s
#3
Brandon Berry, Ester Carolina Apesoa-Varano
Older adults consume the most prescription medication in the U.S. For those who develop Alzheimer's disease, risk of medication misuse increases with the progression of the disease. Family members commonly intervene to lessen risks by taking over the management and administering of a medication regimen. Despite the potential for grave harm around the misuse of powerful drugs, few studies provide insight into the household social context of medication use for this disease. Drawing on 60 in-depth interviews conducted in four waves over 2...
July 6, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28732038/analysis-of-patient-data-from-laboratories-during-the-ebola-virus-disease-outbreak-in-liberia-april-2014-to-march-2015
#4
Yuki Furuse, Mosoka Fallah, Hitoshi Oshitani, Ling Kituyi, Nuha Mahmoud, Emmanuel Musa, Alex Gasasira, Tolbert Nyenswah, Bernice Dahn, Luke Bawo
An outbreak of Ebola virus disease (EVD) in Liberia began in March 2014 and ended in January 2016. Epidemiological information on the EVD cases was collected and managed nationally; however, collection and management of the data were challenging at the time because surveillance and reporting systems malfunctioned during the outbreak. EVD diagnostic laboratories, however, were able to register basic demographic and clinical information of patients more systematically. Here we present data on 16,370 laboratory samples that were tested between April 4, 2014 and March 29, 2015...
July 21, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28731439/antihypertensive-treatment-is-associated-with-mri-derived-markers-of-neurodegeneration-and-impaired-cognition-a-propensity-weighted-cohort-study
#5
Jodi D Edwards, Joel Ramirez, Brandy L Callahan, Sheldon W Tobe, Paul Oh, Courtney Berezuk, Krista Lanctôt, Walter Swardfager, Sean Nestor, Alexander Kiss, Stephen Strother, Sandra E Black
BACKGROUND: Hypertension is an important risk factor for Alzheimer's disease (AD) and cerebral small vessel disease. Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are common anti-hypertensive treatments, but have differential effects on cortical amyloid. OBJECTIVE: The objective of this study was to evaluate associations between anti-hypertensive treatment, brain volume, and cognition, using a propensity-weighted analysis to account for confounding by indication...
July 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28730853/dengue-in-the-elderly-a-review
#6
Ray Junhao Lin, Tau Hong Lee, Yee Sin Leo
Changing dengue epidemiological trends have resulted in a shift in the disease burden to the adult population. Older adults suffer from poorer outcomes as compared to their younger counterparts, making clinical management of this sub-population particularly challenging. Areas covered: We present a review of the current literature on the changing epidemiology of dengue in the elderly, the atypical features of the clinical disease in this population with emphasis on severe disease presentations and challenges in the current management strategies...
July 21, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28730547/sideways-fall-induced-impact-force-and-its-effect-on-hip-fracture-risk-a-review
#7
REVIEW
M Nasiri Sarvi, Y Luo
Osteoporotic hip fracture, mostly induced in falls among the elderly, is a major health burden over the world. The impact force applied to the hip is an important factor in determining the risk of hip fracture. However, biomechanical researches have yielded conflicting conclusions about whether the fall-induced impact force can be accurately predicted by the available models. It also has been debated whether or not the effect of impact force has been considered appropriately in hip fracture risk assessment tools...
July 20, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28729887/whole-body-vibration-training-improves-balance-control-and-sit-to-stand-performance-among-middle-aged-and-older-adults-a-pilot-randomized-controlled-trial
#8
Ming-Chen Ko, Long-Shan Wu, Sangwoo Lee, Chien-Chun Wang, Po-Fu Lee, Ching-Yu Tseng, Chien-Chang Ho
BACKGROUND: Aging is associated with decreased balance, which increases falling risk. The objective of the current study was to determine the feasibility and effects of whole-body vibration (WBV) training on knee extensor muscle power, limits of stability, and sit-to-stand performance among community-dwelling middle-aged and older adults in the United States. METHODS: A randomized pilot study with participant blinding was conducted. Feasibility outcomes included recruitment and compliance rate...
2017: European Review of Aging and Physical Activity
https://www.readbyqxmd.com/read/28729011/iranian-brief-pain-inventory-validation-and-application-in-elderly-people-with-cancer-pain
#9
Mahtab Alizadeh-Khoei, Farshad Sharifi, Mohamad Esmaeil Akbari, Reza Fadayevatan, Marjan Haghi
CONTEXT: Cancer is a major health problem in the elderly, and pain is one of the most common symptoms among older patients with cancer. Sufficient pain treatments depend on the accuracy of the pain assessment tool. OBJECTIVES: This study aimed to assess the psychometric properties of the Iranian version of the Brief Pain Inventory (BPI-IR) among elderly individuals with cancer. METHODS: This validation study was conducted with 368 people aged 60+ years old who were undergoing oncology treatments...
July 17, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28728807/the-impact-of-team-based-primary-care-on-health-care-services-utilization-and-costs-quebec-s-family-medicine-groups
#10
Erin Strumpf, Mehdi Ammi, Mamadou Diop, Julie Fiset-Laniel, Pierre Tousignant
We investigate the effects on health care costs and utilization of team-based primary care delivery: Quebec's Family Medicine Groups (FMGs). FMGs include extended hours, patient enrolment and multidisciplinary teams, but they maintain the same remuneration scheme (fee-for-service) as outside FMGs. In contrast to previous studies, we examine the impacts of organizational changes in primary care settings in the absence of changes to provider payment and outside integrated care systems. We built a panel of administrative data of the population of elderly and chronically ill patients, characterizing all individuals as FMG enrollees or not...
July 1, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/28728083/sleep-disturbances-and-risk-of-falls-in-an-old-chinese-population-rugao-longevity-and-ageing-study
#11
Teng Ma, Guoping Shi, Yinsheng Zhu, Yong Wang, Xuefeng Chu, Xiaoyan Jiang, Zuyun Liu, Jian Cai, Hongfei Wang, Li Jin, Zhendong Wang, Xiaofeng Wang
BACKGROUND: To explore the relationship between sleep disturbances and falls in an elderly Chinese population. METHODS: Data from 1726 individuals aged 70-87 years from the Rugao Longevity and Ageing Study were used. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep variables. Outcomes were falls ≥1 time per year and falls ≥2 times per year. RESULTS: A total of 22.7% of the participants experienced ≥1 fall, and 9.8% experienced ≥2 falls per year...
July 12, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28724399/health-needs-access-to-healthcare-and-perceptions-of-ageing-in-an-urbanizing-community-in-india-a-qualitative-study
#12
Nandita Bhan, Pavitra Madhira, Arundati Muralidharan, Bharati Kulkarni, Gvs Murthy, Sanjay Basu, Sanjay Kinra
BACKGROUND: India's elderly population is rising at an unprecedented rate, with a majority living in rural areas. Health challenges associated with ageing, changing social networks and limited public health infrastructure are issues faced by the elderly and caregivers. We examined perceptions of health needs of the elderly across local stakeholders in an urbanizing rural area. METHODS: The qualitative study was conducted among participants in the Andhra Pradesh Children and Parents Study (APCAPS) site in Rangareddy district, Telangana...
July 19, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28723964/development-of-the-korean-adult-reading-test-kart-to-estimate-premorbid-intelligence-in-dementia-patients
#13
Dahyun Yi, Eun Hyun Seo, Ji Young Han, Bo Kyung Sohn, Min Soo Byun, Jun Ho Lee, Young Min Choe, Suzy Ahn, Jong Inn Woo, Jongho Jun, Dong Young Lee
We aimed to develop a word-reading test for Korean-speaking adults using irregularly pronounced words that would be useful for estimation of premorbid intelligence. A linguist who specialized in Korean phonology selected 94 words that have irregular relationship between orthography and phonology. Sixty cognitively normal elderly (CN) and 31 patients with Alzheimer's disease (AD) were asked to read out loud the words and were administered the Wechsler Adult Intelligence Scale, 4th edition, Korean version (K-WAIS-IV)...
2017: PloS One
https://www.readbyqxmd.com/read/28722466/assessing-the-generalizability-of-the-national-lung-screening-trial-comparison-of-stage-1-patients
#14
Nichole T Tanner, Lin Dai, Brett C Bade, Mulugeta Gebregziabher, Gerard A Silvestri
RATIONALE: The findings of the National Lung Screening Trial (NLST) is the basis for screening high risk individuals based on age and smoking history. While screening is covered for eligible Medicare beneficiaries, the generalizability of the NLST in the elderly population has been questioned. OBJECTIVE: Compare outcomes of patients diagnosed with stage 1 non-small cell lung cancer(NSCLC) in the NLST to a nationally representative cohort of elderly patients Methods: Analysis of SEER-Medicare and NLST datasets for stage 1 patients ages 65-74 Measurements and Main Results: Lung cancer-specific mortality, all-cause mortality, and 30-60-90 day treatment mortality were measured...
July 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28722190/estimating-population-effects-of-vaccination-using-large-routinely-collected-data
#15
M Elizabeth Halloran, Michael G Hudgens
Vaccination in populations can have several kinds of effects. Establishing that vaccination produces population-level effects beyond the direct effects in the vaccinated individuals can have important consequences for public health policy. Formal methods have been developed for study designs and analysis that can estimate the different effects of vaccination. However, implementing field studies to evaluate the different effects of vaccination can be expensive, of limited generalizability, or unethical. It would be advantageous to use routinely collected data to estimate the different effects of vaccination...
July 19, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28721754/a-model-of-adaptation-for-families-of-elderly-patients-with-dementia-focusing-on-family-resilience
#16
Geun Myun Kim, Ji Young Lim, Eun Joo Kim, Sang Suk Kim
OBJECTIVES: We constructed a model explaining families' positive adaptation in chronic crisis situations such as the problematic behavior of elderly patients with dementia and attendant caregiving stress, based on the family resilience model. Our aim was to devise an adaptation model for families of elderly patients with dementia. METHOD: A survey of problematic behavior in elderly patients with dementia, family stress, family resilience, and family adaptation was conducted with 292 consenting individuals...
July 19, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28721427/prevalence-of-frailty-in-nursing-home-residents-according-to-various-diagnostic-tools
#17
F Buckinx, J-Y Reginster, S Gillain, J Petermans, T Brunois, O Bruyère
BACKGROUND: Although the theoretical foundations of frailty are well established in the literature, it remains an evolving concept lacking any unique definition or diagnostic criteria for use in clinical practice and epidemiological research. No consensus exists about the accurate prevalence rates of frailty. The various operational definitions of frailty can at least partly explain such discrepancies. OBJECTIVE: To compare the prevalence of frailty, measured with different diagnostic tools, among elderly nursing home residents...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/28720796/eeg-machine-learning-for-accurate-detection-of-cholinergic-intervention-and-alzheimer-s-disease
#18
Sonja Simpraga, Ricardo Alvarez-Jimenez, Huibert D Mansvelder, Joop M A van Gerven, Geert Jan Groeneveld, Simon-Shlomo Poil, Klaus Linkenkaer-Hansen
Monitoring effects of disease or therapeutic intervention on brain function is increasingly important for clinical trials, albeit hampered by inter-individual variability and subtle effects. Here, we apply complementary biomarker algorithms to electroencephalography (EEG) recordings to capture the brain's multi-faceted signature of disease or pharmacological intervention and use machine learning to improve classification performance. Using data from healthy subjects receiving scopolamine we developed an index of the muscarinic acetylcholine receptor antagonist (mAChR) consisting of 14 EEG biomarkers...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28719103/associations-between-neighborhood-food-environments-and-deficient-protein-intake-among-elderly-people-in-a-metropolitan-suburb-a-case-study-in-kisarazu-city-japan
#19
Yuri Hamamatsu, Chiho Goto, Masaru Nishitani, Riko Shimadate, Junko Ueno, Yoko Kusakari, Masahiro Umezaki
OBJECTIVES: Living in a poor food environment and its association with an increased risk of inadequate nutrient intake are increasingly important issues in Japan due to an increase in the elderly population. METHODS: The present study examined the relationships between neighborhood food environment and the protein and fat intakes of elderly Japanese individuals (n = 181) living in the metropolitan Tokyo suburb of Kisarazu. RESULTS: A logistic regression analysis adjusted for sociodemographic and shopping behavior variables revealed associations between subjectively evaluated poor neighborhood food environment and deficient protein intake...
July 18, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28718008/the-effect-of-vitamin%C3%A2-d-and-calcium-supplementation-on-falls-in-older-adults-a%C3%A2-systematic-review-and-meta-analysis
#20
Haiting Wu, Qingjiang Pang
OBJECTIVES: A number of studies have hypothesized that vitamin D is a potential factor in the prevention of falls in the elderly; however, the effect of vitamin D is still inconsistent and not quantitative. We conducted this meta-analysis to assess the effect of vitamin D on falls among elderly individuals. METHODS: The PubMed and Cochrane Library databases were searched from the earliest possible year up to December 2016. Two authors working independently reviewed the trials, and odds ratios (ORs) were calculated using a fixed-effect or random-effect model by Review Manager 5...
July 17, 2017: Der Orthopäde
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