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https://www.readbyqxmd.com/read/29332302/preoperative-cognitive-impairment-as-a-predictor-of-postoperative-outcomes-in-a-collaborative-care-model
#1
Kahli Zietlow, Shelley R McDonald, Richard Sloane, Jeffrey Browndyke, Sandhya Lagoo-Deenadayalan, Mitchell T Heflin
OBJECTIVES: To compare postoperative outcomes of individuals with and without cognitive impairment enrolled in the Perioperative Optimization of Senior Health (POSH) program at Duke University, a comanagement model involving surgery, anesthesia, and geriatrics. DESIGN: Retrospective analysis of individuals enrolled in a quality improvement program. SETTING: Tertiary academic center. PARTICIPANTS: Older adults undergoing surgery and referred to POSH (N = 157)...
January 13, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29332145/the-experiences-and-beliefs-of-older-people-in-scottish-very-sheltered-housing-about-using-multi-compartment-compliance-aids
#2
Derek Stewart, Kathrine Gibson Smith, Joan MacLeod, Alison Strath, Vibhu Paudyal, Katrina Forbes-McKay, Scott Cunningham, Katie MacLure
Background Multi-compartment compliance aids (MCAs) are promoted as a potential solution to medicines non-adherence despite the absence of high quality evidence of effectiveness of MCA use impacting medicines adherence or any clinical outcomes. Furthermore, there is a lack of qualitative research which focuses on the perspectives of older people receiving MCAs. Objectives To describe experiences and beliefs surrounding very sheltered housing (VSH) residents' use of MCAs with emphasis on issues of personalisation, reablement, shared decision-making, independence and support...
January 13, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29332020/predictors-of-improvements-in-mental-health-from-mindfulness-meditation-in-stressed-older-adults
#3
Barry S Oken, Elena Goodrich, Daniel Klee, Tabatha Memmott, Jeffrey Proulx
Context • The benefits of a mindfulness meditation (MM) intervention are most often evidenced by improvements in self-rated stress and mental health. Given the physiological complexity of the psychological stress system, it is likely that some people benefit significantly, whereas others do not. Clinicians and researchers could benefit from further exploration to determine which baseline factors can predict clinically significant improvements from MM. Objectives • The study intended to determine (1) whether the baseline measures for participants who significantly benefitted from MM training were different from the baseline measures of participants who did not, and (2) whether a classification analysis using a decision-tree, machine-learning approach could be useful in predicting which individuals would be most likely to improve...
January 2018: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29332011/examining-the-utility-of-cystatin-c-as-a-confirmatory-test-of-chronic-kidney-disease-across-the-age-range-in-middle-aged-and-older-community-dwelling-adults
#4
Mark Canney, Donal J Sexton, Neil O'Leary, Martin Healy, Rose Anne Kenny, Mark A Little, Conall M O'Seaghdha
BACKGROUND: Cystatin C has been proposed as a confirmatory test of chronic kidney disease (CKD). This is most applicable to older individuals with CKD, the majority of whom have a creatinine-based estimated glomerular filtration rate (eGFR) of 45-59 mL/min/1.73 m2 (CKD stage 3a). We sought to examine the utility of cystatin C as a confirmatory test of CKD across the age range in the general population of older adults. METHODS: Cross-sectional analysis of 5386 participants from The Irish Longitudinal Study on Ageing, a cluster-sampled national cohort of community-dwelling adults aged ≥50 years...
January 13, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29331976/concealment-of-type-1-diabetes-at-work-in-finland-a-mixed-method-study
#5
Pirjo Hakkarainen, Fehmidah Munir, Leena Moilanen, Kimmo Räsänen, Vilma Hänninen
OBJECTIVES: To explore the possible reasons for concealing type 1 diabetes (T1D) at work. METHODS: The main set of data came from a cross-sectional survey (response rate 49.3%), the participants of which were 688 wage earners with T1D. Concealment of T1D was measured by asking respondents have they ever during their working career hidden their diabetes from their (A) colleagues and (B) line manager. Furthermore, semistructured interviews (n=20) were conducted to obtain deeper understanding...
January 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29331877/cerebral-changes-and-disrupted-gray-matter-cortical-networks-in-asymptomatic-older-adults-at-risk-for-alzheimer-s-disease
#6
Jose L Cantero, Mercedes Atienza, Pascual Sanchez-Juan, Eloy Rodriguez-Rodriguez, Jose Luis Vazquez-Higuera, Ana Pozueta, Andrea Gonzalez-Suarez, Eduard Vilaplana, Jordi Pegueroles, Victor Montal, Rafael Blesa, Daniel Alcolea, Alberto Lleo, Juan Fortea
The diagnostic value of cerebrospinal fluid (CSF) biomarkers is well established in Alzheimer's disease, but our current knowledge about how abnormal CSF levels affect cerebral integrity, at local and network levels, is incomplete in asymptomatic older adults. Here, we have collected CSF samples and performed structural magnetic resonance imaging scans in cognitively normal elderly as part of a cross-sectional multicenter study (SIGNAL project). To identify group differences in cortical thickness, white matter volume, and properties of structural networks, participants were split into controls (N = 20), positive amyloid-β (Aβ1-42+) (N = 19), and positive phosphorylated tau (N = 18)...
December 20, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29331849/sociodemographic-lifestyle-and-health-determinants-of-suicidal-behaviour-in-malaysia
#7
Yong Kang Cheah, Mohd Azahadi, Siew Nooi Phang, Noor Hazilah Abd Manaf
Suicide has become a serious matter in both developed and developing countries. The objective of the present study is to examine the factors affecting suicidal behaviour among adults in Malaysia. A nationally representative data which consists of 10,141 respondents is used for analysis. A trivariate probit model is utilised to identify the probability of having suicide ideation, suicide plan and suicide attempt. Results of the regression analysis show that to ensure unbiased estimates, a trivariate probit model should be used instead of three separate probit models...
January 5, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29331536/chronic-inflammation-and-sarcopenia-a-regenerative-cell-therapy-perspective
#8
Jagadish K Chhetri, Philipe de Souto Barreto, Bertrand Fougère, Yves Rolland, Bruno Vellas, Matteo Cesari
Sarcopenia is characterized by reduced skeletal muscle mass and strength in older individuals. It is one of the leading cause of physical limitation in older adults, and associated with wide spectrum of adverse events including disability and mortality. The phenomenon of chronic-inflammation or inflamm-aging with aging is known to be a major contributor to myriad of geriatric conditions including sarcopenia. Recent advances in regenerative medicine, in particular cell therapy have opened up new possibilities to ameliorate broad range of inflammatory disorders...
January 10, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29331311/prediction-of-mortality-in-patients-with-chronic-obstructive-pulmonary-disease-with-the-new-global-initiative-for-chronic-obstructive-lung-disease-2017-classification-a-cohort-study
#9
Anne Gedebjerg, Szimonetta Komjáthiné Szépligeti, Laura-Maria Holm Wackerhausen, Erzsébet Horváth-Puhó, Ronald Dahl, Jens Georg Hansen, Henrik Toft Sørensen, Mette Nørgaard, Peter Lange, Reimar Wernich Thomsen
BACKGROUND: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 classification separates the spirometric 1-4 staging from the ABCD groups defined by symptoms and exacerbations. Little is known about how this new classification predicts mortality in patients with chronic obstructive pulmonary disease (COPD). We aimed to establish the predictive ability of the GOLD 2017 classification, compared with earlier classifications, for all-cause and respiratory mortality, both when using its main ABCD groups and when further subdividing according to spirometric 1-4 staging...
January 10, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29330835/international-guidelines-for-groin-hernia-management
#10
(no author information available yet)
INTRODUCTION: Worldwide, more than 20 million patients undergo groin hernia repair annually. The many different approaches, treatment indications and a significant array of techniques for groin hernia repair warrant guidelines to standardize care, minimize complications, and improve results. The main goal of these guidelines is to improve patient outcomes, specifically to decrease recurrence rates and reduce chronic pain, the most frequent problems following groin hernia repair. They have been endorsed by all five continental hernia societies, the International Endo Hernia Society and the European Association for Endoscopic Surgery...
January 12, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29330818/trace-elements-in-four-freshwater-fish-from-a-mine-impacted-river-spatial-distribution-species-specific-accumulation-and-risk-assessment
#11
Yuyu Jia, Lin Wang, Junfei Cao, Shan Li, Zhaoguang Yang
The concentrations of 16 elements (Mg, Al, Ca, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Sr, Cd, Ba, and Pb) were determined in four fish species (Carassius auratus, Squaliobarbus curriculus, Pelteobagrus fulvidraco, and Silurus asotus) collected in the Xiang River, a mine-impacted river in Southern China. The mean values of the elements analyzed in fish muscles were in the decreasing order of Mg > Ca > Zn > Fe > Sr > Al > Cu > Mn > Ba > As > Cr > Pb > Ni > V > Co > Cd...
January 12, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29330643/antihypertensive-medication-and-dementia-risk-in-older-adult-african-americans-with-hypertension-a-prospective-cohort-study
#12
Michael D Murray, Hugh C Hendrie, Kathleen A Lane, Mengjie Zheng, Roberta Ambuehl, Shanshan Li, Frederick W Unverzagt, Christopher M Callahan, Sujuan Gao
BACKGROUND: African Americans are especially at risk of hypertension and dementia. Antihypertensive medications reduce the risk of cardiovascular events, but may also reduce the risk of dementia. OBJECTIVE: To assess the longitudinal effects of antihypertensive medications and blood pressure on the onset of incident dementia in a cohort of African Americans. DESIGN: Prospective cohort. PARTICIPANTS: 1236 community-dwelling patients from an inner-city public health care system, aged 65 years and older, with a history of hypertension but no history of dementia, and who had at least three primary care visits and a prescription filled for any medication...
January 12, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29330585/potentially-inappropriate-medications-in-community-dwelling-older-adults-undertaken-as-a-comprehensive-geriatric-risk-assessment
#13
Sharmin S Bala, Sujita W Narayan, Prasad S Nishtala
PURPOSE: The prescription of potentially inappropriate medications (PIMs) is associated with an increase in adverse events, prescribing cascades, high health-care costs, morbidity, and mortality in the elderly. The overarching objective of this study is to examine the prevalence of PIMs in the elderly, applying the 2012 American Geriatrics Society Beers criteria for the study period 2012-2014, and the updated 2015 Beers criteria for 2015. METHODS: The study population (N = 70,479) included a continuously recruited national cohort of community-dwelling older (aged ≥ 65 years) New Zealanders who had undertaken the International Resident Assessment Instrument-Home Care (interRAI-HC) assessments between September 2012 and October 2015...
January 12, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29330420/left-ventricular-hypertrophy-and-cognitive-function-a-systematic-review
#14
C Restrepo, S K Patel, V Rethnam, E Werden, J Ramchand, L Churilov, L M Burrell, A Brodtmann
Cognitive impairment is common in patients with hypertension. Left ventricular hypertrophy (LVH) is recognised as a marker of hypertension-related organ damage and is a strong predictor of coronary artery disease, heart failure and stroke. There is evidence that LVH is independently associated with cognitive impairment, even after adjustment for the presence of hypertension. We conducted a systematic review that examined cognitive impairment in adults with LVH. Independent searches were performed in Ovid MEDLINE, Ovid psycInfo and PubMed with the terms left ventricular hypertrophy and cognition...
January 12, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29330356/metabolic-and-molecular-changes-associated-with-the-increased-skeletal-muscle-insulin-action-24-48%C3%A2-h-after-exercise-in-young-and-old-humans
#15
REVIEW
Francis B Stephens, Kostas Tsintzas
The molecular and metabolic mechanisms underlying the increase in insulin sensitivity (i.e. increased insulin-stimulated skeletal muscle glucose uptake, phosphorylation and storage as glycogen) observed from 12 to 48 h following a single bout of exercise in humans remain unresolved. Moreover, whether these mechanisms differ with age is unclear. It is well established that a single bout of exercise increases the translocation of the glucose transporter, GLUT4, to the plasma membrane. Previous research using unilateral limb muscle contraction models in combination with hyperinsulinaemia has demonstrated that the increase in insulin sensitivity and glycogen synthesis 24 h after exercise is also associated with an increase in hexokinase II (HKII) mRNA and protein content, suggesting an increase in the capacity of the muscle to phosphorylate glucose and divert it towards glycogen synthesis...
January 12, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29330165/survival-in-relation-to-multimorbidity-patterns-in-older-adults-in-primary-care-in-barcelona-spain-2010-2014-a-longitudinal-study-based-on-electronic-health-records
#16
Carolina Ibarra-Castillo, Marina Guisado-Clavero, Concepció Violan-Fors, Mariona Pons-Vigués, Tomàs López-Jiménez, Albert Roso-Llorach
BACKGROUND: Several studies have analysed the characteristics of multimorbidity patterns but none have evaluated the relationship with survival. The purpose of this study was to compare survival across older adults with different chronic multimorbidity patterns (CMPs). METHODS: Prospective longitudinal observational study using electronic health records for 190 108 people aged ≥65 years in Barcelona, Spain (2009-2014). CMPs were identified by cluster analysis...
January 12, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29330028/perceptions-of-the-relative-harmfulness-of-marijuana-and-alcohol-among-adults-in-oregon
#17
Jane A Allen, Matthew C Farrelly, Jennifer C Duke, Kian Kamyab, James M Nonnemaker, Sarah Wylie, Lauren Dutra, Camille Gourdet
This study documents perceptions of the relative harmfulness of marijuana and alcohol to a person's health among adults in Oregon just before the first legal sales of marijuana for recreational use. We surveyed 1941 adults in Oregon in September 2015. Respondents were recruited using an address-based sampling (ABS) frame (n = 1314) and social media advertising (n = 627). Respondents completed paper surveys (ABS-mail, n = 388) or online surveys (ABS-online, n = 926; social media, n = 627)...
January 9, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29329596/the-epidemiology-of-psoriatic-arthritis-in-israel-a-population-based-study
#18
Lihi Eder, Arnon Dov Cohen, Ilan Feldhamer, Sari Greenberg-Dotan, Erez Batat, Devy Zisman
BACKGROUND: There is limited information on the epidemiology of psoriatic arthritis (PsA) in general and in Middle Eastern populations in particular. The aims of this study were to estimate the prevalence and incidence rates of PsA and their temporal trends in the general population in Israel. METHODS: In this study, a cohort of adult patients with PsA was derived from the database of Clalit Health Services (CHS), Israel's largest health fund, with over 4.4 million members...
January 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29329536/dietary-flavonoid-intake-in-older-adults-how-many-days-of-dietary-assessment-are-required-and-what-is-the-impact-of-seasonality
#19
Katherine Kent, Karen E Charlton, Simone Lee, Jonathon Mond, Joanna Russell, Paul Mitchell, Victoria M Flood
BACKGROUND: Within- and between-person variation in nutrient intake is well established, but little is known about variability in dietary flavonoid intake, including the effect of seasonality. METHODS: Within- and between-individual variability of flavonoid intake, and intake of flavonoid subclasses was examined in older adults (n = 79; mean age 70.1 y (range: 60y-80y)), using three separate 4-day weighed food records (WFR) collected approximately 4 months apart...
January 12, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29329455/serologic-evidence-of-ebolavirus-infection-in-a-population-with-no-history-of-outbreaks-in-the-democratic-republic-of-the-congo
#20
Sabue Mulangu, Vivian H Alfonso, Nicole A Hoff, Reena H Doshi, Prime Mulembakani, Neville K Kisalu, Emile Okitolonda-Wemakoy, Benoit Ilunga Kebela, Hadar Marcus, Joseph Shiloach, Je Nie Phue, Linda L Wright, Jean-Jacques Muyembe-Tamfum, Nancy J Sullivan, Anne W Rimoin
Background: Previous studies suggest that cases of Ebola virus disease (EVD) may go unreported because they are asymptomatic or unrecognized, but evidence is limited by study designs and sample size. Methods: A large population-based survey was conducted (n = 3415) to assess animal exposures and behaviors associated with Ebolavirus antibody prevalence in rural Kasai Oriental province of the Democratic Republic of Congo (DRC). Fourteen villages were randomly selected and all healthy individuals ≥1 year of age were eligible...
January 10, 2018: Journal of Infectious Diseases
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