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https://www.readbyqxmd.com/read/29241908/laboratory-and-clinical-significance-of-macroprolactinemia-in-women-with-hyperprolactinemia
#1
REVIEW
Miro Kasum, Slavko Orešković, Ermin Čehić, Martina Šunj, Albert Lila, Emina Ejubović
The role of macroprolactinemia in women with hyperprolactinemia is currently controversial and can lead to clinical dilemmas, depending upon the origin of macroprolactin, the presence of hyperprolactinemic symptoms and monomeric prolactin (PRL) levels. Macroprolactinemia is mostly considered an extrapituitary phenomenon of mild and asymptomatic hyperprolactinemia associated with normal concentrations of monomeric PRL and a predominance of macroprolactin confined to the vascular system, which is biologically inactive...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29219604/phonon-sidebands-in-monolayer-transition-metal-dichalcogenides
#2
Dominik Christiansen, Malte Selig, Gunnar Berghäuser, Robert Schmidt, Iris Niehues, Robert Schneider, Ashish Arora, Steffen Michaelis de Vasconcellos, Rudolf Bratschitsch, Ermin Malic, Andreas Knorr
Excitons dominate the optical properties of monolayer transition metal dichalcogenides (TMDs). Besides optically accessible bright exciton states, TMDs exhibit also a multitude of optically forbidden dark excitons. Here, we show that efficient exciton-phonon scattering couples bright and dark states and gives rise to an asymmetric excitonic line shape. The observed asymmetry can be traced back to phonon-induced sidebands that are accompanied by a polaron redshift. We present a joint theory-experiment study investigating the microscopic origin of these sidebands in different TMD materials taking into account intra- and intervalley scattering channels opened by optical and acoustic phonons...
November 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29212848/association-of-complement-receptor-1-gene-polymorphisms-with-cognitive-function
#3
Laurien Ermine Zijlstra, J Wouter Jukema, Simon P Mooijaart, Marijke A de Vries, David J Stott, Manuel Castro Cabezas, Stella Trompet
Previous evidence suggest involvement of the complement receptor 1 (CR1) in development of Alzheimer's disease. We investigated the association of CR1 gene polymorphisms with cognitive function in older subjects. Single nucleotide polymorphisms (SNPs) within the CR1 region on chromosome 1 (n=73) were assessed in 5244 participants in the PROspective Study of Pravastatin in the Elderly at Risk (51.9% female, mean age75.3 years). Linear regression, adjusted for age, sex, country and use of pravastatin, was used to assess the association between the SNPs and cognitive function, All 73 SNPs within the genomic region of the CR1 gene on chromosome 1 were extracted...
December 6, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/29120551/current-medical-strategies-in-the-prevention-of-ovarian-hyperstimulation-syndrome
#4
Miro Kasum, Slavko Orešković, Daniela Franulić, Ermin Čehić, Albert Lila, Goran Vujić, Franjo Grgić
The purpose of this review is to analyze current medical strategies in the prevention of ovarian hyperstimulation syndrome (OHSS) during ovarian stimulation for in vitro fertilization. Owing to contemporary preventive measures of OHSS, the incidence of moderate and severe forms of the syndrome varies between 0.18% and 1.40%. Although none of medical strategies is completely effective, there is high-quality evidence that replacing human chorionic gonadotropin (hCG) by gonadotropin-releasing hormone (GnRH) agonists after GnRH antagonists and moderate- quality evidence that GnRH antagonist protocols, dopamine agonists and mild protocols reduce the occurrence of OHSS...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29037105/the-role-of-female-obesity-on-in-vitro-fertilization-outcomes
#5
Miro Kasum, Slavko Orešković, Ermin Čehić, Albert Lila, Emina Ejubović, Dragan Soldo
The aim of this review is to analyze the role of obesity on fertility outcome in women undergoing in vitro fertilization (IVF) with respect to clinical or live birth rates and pregnancy loss rates. Despite findings from several earlier and newer studies that obesity does not adversely affect pregnancy outcome in women attempting conception, numerous reports from mostly recent studies suggest that obesity undoubtedly impairs IVF outcomes. Obesity impairs ovarian responsiveness to gonadotrophin stimulation, requiring higher doses of medication, increased risk of cycle cancelation, pre-term delivery, low birth weight or miscarriage, and decreases implantation, clinical pregnancy or live birth rates compared to women of normal weight...
October 16, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28949645/symmetry-breaking-supercollisions-in-landau-quantized-graphene
#6
Florian Wendler, Martin Mittendorff, Jacob C König-Otto, Samuel Brem, Claire Berger, Walter A de Heer, Roman Böttger, Harald Schneider, Manfred Helm, Stephan Winnerl, Ermin Malic
Recent pump-probe experiments performed on graphene in a perpendicular magnetic field have revealed carrier relaxation times ranging from picoseconds to nanoseconds depending on the quality of the sample. To explain this surprising behavior, we propose a novel symmetry-breaking defect-assisted relaxation channel. This enables scattering of electrons with single out-of-plane phonons, which drastically accelerate the carrier scattering time in low-quality samples. The gained insights provide a strategy for tuning the carrier relaxation time in graphene and related materials by orders of magnitude...
August 11, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28911338/organisational-culture-and-trust-as-influences-over-the-implementation-of-equity-oriented-policy-in-two-south-african-case-study-hospitals
#7
Ermin Erasmus, Lucy Gilson, Veloshnee Govender, Moremi Nkosi
BACKGROUND: This paper uses the concepts of organisational culture and organisational trust to explore the implementation of equity-oriented policies - the Uniform Patient Fee Schedule (UPFS) and Patients' Rights Charter (PRC) - in two South African district hospitals. It contributes to the small literatures on organisational culture and trust in low- and middle-income country health systems, and broader work on health systems' people-centeredness and "software". METHODS: The research entailed semi-structured interviews (Hospital A n = 115, Hospital B n = 80) with provincial, regional, district and hospital managers, as well as clinical and non-clinical hospital staff, hospital board members, and patients; observations of policy implementation, organisational functioning, staff interactions and patient-provider interactions; and structured surveys operationalising the Competing Values Framework for measuring organisational culture (Hospital A n = 155, Hospital B n = 77) and Organisational Trust Inventory (Hospital A n = 185, Hospital B n = 92) for assessing staff-manager trust...
September 15, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28880032/in-vitro-and-in-vivo-inhibitory-effects-of-a-pleurotus-eryngii-protein-on-colon-cancer-cells
#8
Biao Yuan, Ning Ma, Liyan Zhao, Ermin Zhao, Zili Gao, Weicang Wang, Mingyue Song, Guodong Zhang, Qiuhui Hu, Hang Xiao
Edible mushrooms have been considered as a good source of bioactive components with various health benefits. Our previous study demonstrated the identity of a novel protein from Pleurotus eryngii, namely PEP, and its anti-inflammatory activities. Herein, we further determined the inhibitory effects of PEP against colon cancer cells. PEP suppressed the proliferation of human and murine colon cancer HCT116 and MC38 cells in a dose and time-dependent fashion, while it showed no inhibitory effect on normal human colonic myofibroblasts CCD-18Co at the same concentrations tested...
September 7, 2017: Food & Function
https://www.readbyqxmd.com/read/28815590/juxtanodin-in-retinal-pigment-epithelial-cells-expression-and-biological-activities-in-regulating-cell-morphology-and-actin-cytoskeleton-organization
#9
Fengyi Liang, Ji Hyun Hwang, Nicholas Weiwei Tang, Walter Hunziker
Juxtanodin (also known as ermin) was initially identified as an actin cytoskeleton-related oligodendroglial protein in the rat central nervous system. It was subsequently also found in the rat olfactory neuroepithelium, especially at the apical junctional belt of the sustentacular cells. We further examined juxtanodin expression and functional roles in the retina using fluorescence histochemistry, confocal microscopy, immuno-electron microscopy, molecular biology and cell culture. Prominent juxtanodin expression was found in the photoreceptor-supporting retinal pigment epithelium (RPE), especially in a zone corresponding to the apices of RPE cells, at the roots of the RPE microvilli, and at the base of RPE cells next to the Bruch's membrane...
August 17, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28790543/haemorrhage-rates-after-two-commonly-used-tonsillectomy-methods-a-multicenter-study
#10
Faris Brkic, Majda Mujic, Sekib Umihanic, Nermin Hrncic, Amna Goga, Ermin Goretic
INTRODUCTION: Tonsillectomy is a frequently used, low-risk surgical procedure. The post-tonsillectomy haemorrhage occurs rarely, but is a life-threatening complication. Some studies show that the surgical technique affects the haemorrhage rate. AIMS: To analyse the post-tonsillectomy haemorrhage rate, and to determine whether the effect of the surgical technique on the haemorrhage rate exists. METHODS: We retrospectively reviewed data of all patients who underwent a tonsillectomy in three regional ENT departments in Bosnia and Herzegovina (Tuzla, Zenica and Bihac) between January 1(st) 2015 and October 31(st) 2016...
April 2017: Medical Archives
https://www.readbyqxmd.com/read/28768687/hit-ndrive-patient-specific-multidriver-gene-prioritization-for-precision-oncology
#11
Raunak Shrestha, Ermin Hodzic, Thomas Sauerwald, Phuong Dao, Kendric Wang, Jake Yeung, Shawn Anderson, Fabio Vandin, Gholamreza Haffari, Colin C Collins, S Cenk Sahinalp
Prioritizing molecular alterations that act as drivers of cancer remains a crucial bottleneck in therapeutic development. Here we introduce HIT'nDRIVE, a computational method that integrates genomic and transcriptomic data to identify a set of patient-specific, sequence-altered genes, with sufficient collective influence over dysregulated transcripts. HIT'nDRIVE aims to solve the "random walk facility location" (RWFL) problem in a gene (or protein) interaction network, which differs from the standard facility location problem by its use of an alternative distance measure: "multihitting time," the expected length of the shortest random walk from any one of the set of sequence-altered genes to an expression-altered target gene...
September 2017: Genome Research
https://www.readbyqxmd.com/read/28720581/hit-ndrive-patient-specific-multi-driver-gene-prioritization-for-precision-oncology
#12
Raunak Shrestha, Ermin Hodzic, Thomas Sauerwald, Phuong Dao, Kendric Wang, Jake Yeung, Shawn Anderson, Fabio Vandin, Gholamreza Haffari, Colin C Collins, Cenk Sahinalp
Prioritizing molecular alterations that act as drivers of cancer remains a crucial bottleneck in therapeutic development. Here we introduce HIT'nDRIVE, a computational method that integrates genomic and transcriptomic data to identify a set of patient-specific, sequence-altered genes, with sufficient collective influence over dysregulated transcripts. HIT'nDRIVE aims to solve the "random walk facility location" (RWFL) problem in a gene (or protein) interaction network, which differs from the standard facility location problem by its use of an alternative distance measure: "multi-hitting time", the expected length of the shortest random walk from any one of the set of sequence-altered genes to an expression-altered target gene...
July 18, 2017: Genome Research
https://www.readbyqxmd.com/read/28691918/optical-fingerprint-of-non-covalently-functionalized-transition-metal-dichalcogenides
#13
Maja Feierabend, Ermin Malic, Andreas Knorr, Gunnar Berghäuser
Atomically thin transition metal dichalcogenides (TMDs) hold promising potential for applications in optoelectronics. Due to their direct band gap and the extraordinarily strong Coulomb interaction, TMDs exhibit efficient light-matter coupling and tightly bound excitons. Moreover, large spin orbit coupling in combination with circular dichroism allows for spin and valley selective optical excitation. As atomically thin materials, they are very sensitive to changes in the surrounding environment. This motivates a functionalization approach, where external molecules are adsorbed to the materials surface to tailor its optical properties...
September 27, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28542564/the-pet-and-lim1-2-domains-of-testin-contribute-to-intramolecular-and-homodimeric-interactions
#14
Stefano Sala, Marie Catillon, Ermin Hadzic, Elisabeth Schaffner-Reckinger, Marleen Van Troys, Christophe Ampe
The focal adhesion protein testin is a modular scaffold and tumour suppressor that consists of an N-terminal cysteine rich (CR) domain, a PET domain of unknown function and three C-terminal LIM domains. Testin has been proposed to have an open and a closed conformation based on the observation that its N-terminal half and C-terminal half directly interact. Here we extend the testin conformational model by demonstrating that testin can also form an antiparallel homodimer. In support of this extended model we determined that the testin region (amino acids 52-233) harbouring the PET domain interacts with the C-terminal LIM1-2 domains in vitro and in cells, and assign a critical role to tyrosine 288 in this interaction...
2017: PloS One
https://www.readbyqxmd.com/read/28485387/unconventional-double-bended-saturation-of-carrier-occupation-in-optically-excited-graphene-due-to-many-particle-interactions
#15
Torben Winzer, Martin Mittendorff, Stephan Winnerl, Henry Mittenzwey, Roland Jago, Manfred Helm, Ermin Malic, Andreas Knorr
Saturation of carrier occupation in optically excited materials is a well-established phenomenon. However, so far, the observed saturation effects have always occurred in the strong-excitation regime and have been explained by Pauli blocking of the optically filled quantum states. On the basis of microscopic theory combined with ultrafast pump-probe experiments, we reveal a new low-intensity saturation regime in graphene that is purely based on many-particle scattering and not Pauli blocking. This results in an unconventional double-bended saturation behaviour: both bendings separately follow the standard saturation model exhibiting two saturation fluences; however, the corresponding fluences differ by three orders of magnitude and have different physical origin...
May 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28470501/assessment-of-long-range-transport-potential-of-polychlorinated-naphthalenes-based-on-three-dimensional-qsar-models
#16
Xiaolei Wang, Wenen Gu, Ermin Guo, Chunyue Cui, Yu Li
Experimentally determined octanol-air partition coefficients (K OA) for 43 polychlorinated naphthalene (PCN) congeners and experimentally determined subcooled liquid vapor pressures (P L) for 17 PCN congeners were used with comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) to generate three-dimensional quantitative structure-activity relationship (3D-QSAR) models. The data were used to predict K OA values for the other 32 congeners and P L values for the other 58 congeners...
June 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28418035/chronic-social-defeat-reduces-myelination-in-the-mouse-medial-prefrontal-cortex
#17
Michael L Lehmann, Thaddeus K Weigel, Abdel G Elkahloun, Miles Herkenham
The medial prefrontal cortex (mPFC) plays a key role in top-down control of the brain's stress axis, and its structure and function are particularly vulnerable to stress effects, which can lead to depression in humans and depressive-like states in animals. We tested whether chronic social defeat produces structural alterations in the mPFC in mice. We first performed a microarray analysis of mPFC gene expression changes induced by defeat, and biological pathway analysis revealed a dominant pattern of down-regulation of myelin-associated genes...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28394547/influence-of-male-obesity-on-fertility
#18
REVIEW
Miro Kasum, Sonja Anić-Jurica, Ermin Čehić, Tajana Klepac-Pulanić, Josip Juras, Kristina Žužul
The aim of this review is to analyze current diagnostic approaches to obesity in adult men, the potential mechanisms linking obesity to infertility, and treatment options aimed at improving reproductive health. Obesity has become a worldwide epidemic with the estimated prevalence increasing from 28.8% to 36.9% between 1980 and 2013. In terms of diagnosis, numerous simple techniques have been developed including body mass index, waist to hip ratio, waist circumference, bioelectrical impedance analysis, ultrasound and skinfold measurements...
June 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/28393578/kisspeptin-as-a-promising-oocyte-maturation-trigger-for-in-vitro-fertilisation-in-humans
#19
Miro Kasum, Daniela Franulić, Ermin Čehić, Slavko Orešković, Albert Lila, Emina Ejubović
The aim of this review is to analyse the effectiveness of exogenous kisspeptin administration as a novel alternative of triggering oocyte maturation, instead of currently used triggers such as human chorionic gonadotropin (hCG) or gonadotropin releasing hormone (GnRH) agonist, in women undergoing in vitro fertilisation (IVF) treatment. Kisspeptin has been considered a master regulator of two modes of GnRH and hence gonadotropin secretion, pulses and surges. Administration of kisspeptin-10 and kisspeptin-54 induces the luteinising hormone (LH) surge required for egg maturation and ovulation in animal investigations and LH release during the preovulatory phase of the menstrual cycle and hypothalamic amenorrhoea in humans...
August 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28294110/proposal-for-dark-exciton-based-chemical-sensors
#20
Maja Feierabend, Gunnar Berghäuser, Andreas Knorr, Ermin Malic
The rapidly increasing use of sensors throughout different research disciplines and the demand for more efficient devices with less power consumption depends critically on the emergence of new sensor materials and novel sensor concepts. Atomically thin transition metal dichalcogenides have a huge potential for sensor development within a wide range of applications. Their optimal surface-to-volume ratio combined with strong light-matter interaction results in a high sensitivity to changes in their surroundings...
March 15, 2017: Nature Communications
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