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Biomaterials larynx

Linqing Li, Jeanna M Stiadle, Elizabeth E Levendoski, Hang K Lau, Susan L Thibeault, Kristi L Kiick
Vocal folds are connective tissues housed in the larynx, which can be subjected to various injuries and traumatic stimuli that lead to aberrant tissue structural alterations and fibrotic-induced biomechanical stiffening observed in patients with voice disorders. Much effort has been devoted to generate soft biomaterials that are injectable directly to sites of injury. To date, materials applied toward these applications have been largely focused on natural extracellular matrix (ECM)-derived materials such as collagen, fibrin or HA; these approaches have suffered from the fact that materials are not sufficiently robust mechanically nor offer sufficient flexibility to modulate material properties for targeted injection...
April 3, 2018: Journal of Biomedical Materials Research. Part A
Maria Siemionow
Over the past 20 years, the fields of biomaterial sciences and tissue engineering have evolved into new clinically relevant applications including regenerative medicine and cell based therapies. Tissue engineering therapies are based on different types of materials and scaffolds combined with cells and submitted to engineering processes in order to create bio-scaffolds which will improve or replace biological functions. Despite the effort, only a few therapies, such as bone, cartilage and nerve, succeeded in clinical applications...
December 2015: Journal of Materials Science. Materials in Medicine
Jonathan M Fishman, Katherine Wiles, Mark W Lowdell, Paolo De Coppi, Martin J Elliott, Anthony Atala, Martin A Birchall
INTRODUCTION: Prosthetic materials, autologous tissues, cryopreserved homografts and allogeneic tissues have thus far proven unsuccessful in providing long-term functional solutions to extensive upper airway disease and damage. Research is therefore focusing on the rapidly expanding fields of regenerative medicine and tissue engineering in order to provide stem cell-based constructs for airway reconstruction, substitution and/or regeneration. AREAS COVERED: Advances in stem cell technology, biomaterials and growth factor interactions have been instrumental in guiding optimization of tissue-engineered airways, leading to several first-in-man studies investigating stem cell-based tissue-engineered tracheal transplants in patients...
October 2014: Expert Opinion on Biological Therapy
Jonathan M Fishman, Mark Lowdell, Martin A Birchall
Tissue engineering requires the use of cells seeded onto scaffolds, often in conjunction with bioactive molecules, to regenerate or replace tissues. Significant advances have been made in recent years within the fields of stem cell biology and biomaterials, leading to some exciting developments in airway tissue engineering, including the first use of stem cell-based tissue-engineered tracheal replacements in humans. In addition, recent advances within the fields of scaffold biology and decellularization offer the potential to transplant patients without the use of immunosuppression...
June 2014: Seminars in Pediatric Surgery
Geraldo P Jotz, Paula R da Luz Soster, Seno O Kunrath, Daniela Steffens, Daikelly I Braghirolli, Claudio Galleano Zettler, Carlos A Beck, Marcelo Muccillo, Rui F F Lopes, Bernardo Mastella, Patricia Pranke
OBJECTIVES/HYPOTHESIS: The aim of this study has been to establish an alternative approach in the form of regeneration of the thyroid cartilage. STUDY DESIGN: Four 1-month old pigs (Sus scrofa) were used (divided into 3 groups) and submitted to general anesthetic to perform cervictomy with exposure of the thyroid cartilage in a total of 12 (twelve) samples. METHOD: A resection of 4.0 cm(2) of cartilage was carried out in the right upper region and in the left upper and lower left region of the cartilage, where a scaffold with or without stem cells was implanted...
December 2014: Laryngoscope
Anthony Sheyn, Ross Mayerhoff, Peter F Svider, Tamar Giorgadze, Paul C Montgomery, Sean Mutchnik, James Coticchia
INTRODUCTION: Laryngotracheal reconstruction is a common procedure to repair subglottic stenosis. Despite a success rate upwards of 85%, this procedure has significant morbidity associated with it, specifically with the site of the graft harvest and recurrence of stenosis. We propose that a recently described cellular bioscaffold xenograft may be useful in reducing these complications. METHODS AND MATERIALS: 10 Sprague Dawley rats were divided into 2 groups of 5...
January 2014: International Journal of Pediatric Otorhinolaryngology
David W Grainger, Henny C van der Mei, Paul C Jutte, Jan J A M van den Dungen, Marcus J Schultz, Bernard F A M van der Laan, Sebastian A J Zaat, Henk J Busscher
Biomaterials-associated infection incidence represents an increasing clinical challenge as more people gain access to medical device technologies worldwide and microbial resistance to current approaches mounts. Few reported antimicrobial approaches to implanted biomaterials ever get commercialized for physician use and patient benefit. This is not for lack of ideas since many thousands of claims to new approaches to antimicrobial efficacy are reported. Lack of translation of reported ideas into medical products approved for use, results from conflicting goals and purposes between the various participants involved in conception, validation, development, commercialization, safety and regulatory oversight, insurance reimbursement, and legal aspects of medical device innovation...
December 2013: Biomaterials
Siavash Kazemirad, Luc Mongeau
An experimental method based on Rayleigh wave propagation was developed for quantifying the frequency-dependent viscoelastic properties of a small volume of expensive biomaterials over a broad frequency range. Synthetic silicone rubber and gelatin materials were fabricated and tested to evaluate the proposed method. Planar harmonic Rayleigh waves at different frequencies, from 80 to 4000 Hz, were launched on the surface of a sample composed of a substrate with known material properties coated with a thin layer of the soft material to be characterized...
June 2013: Journal of the Acoustical Society of America
Markus Gugatschka, Satoshi Ohno, Amulya Saxena, Shigeru Hirano
Tissue engineering is a multidimensional process combining cells, scaffold matrices, and chemical signals to produce a structure similar to a target tissue. These techniques have opened a completely new field in diagnosis and therapy in numerous fields, including that of laryngology. Laryngeal tissue engineering has emerged in the last decade, although clinical applications are rare. The reasons therefore are numerous including ethical reasons, as well as the extremely complex anatomical structure of the vocal fold...
September 2012: Journal of Voice: Official Journal of the Voice Foundation
An-ke Sun, Wan-tong Li, Qing-yan Meng, Song-bo Liu, Wei Chen, Wei-wei Tang
OBJECTIVE: To explore the method of fabricating larynx-shape tissue engineered cartilage by means of filling together with wrapping with pedicle myofascial flap. METHODS: Serial steps of solution casting, extrusion molding and particulate leaching were used to make larynx-shape [poly (3-hydroxybutyrate-co-3-hydroxyhexanoate), PHBHH] biomaterial models. The chondrocytes were seeded onto PHBHH models to form cell-PHBHH composites for culture in vitro for one week and then to fill and wrap larynx-shape composites with pedicle myofascial flap...
December 2011: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Giuseppe Orlando, Kathryn J Wood, Paolo De Coppi, Pedro M Baptista, Kyle W Binder, Khalil N Bitar, Christopher Breuer, Luke Burnett, George Christ, Alan Farney, Marina Figliuzzi, James H Holmes, Kenneth Koch, Paolo Macchiarini, Sayed-Hadi Mirmalek Sani, Emmanuel Opara, Andrea Remuzzi, Jeffrey Rogers, Justin M Saul, Dror Seliktar, Keren Shapira-Schweitzer, Tom Smith, Daniel Solomon, Mark Van Dyke, James J Yoo, Yuanyuan Zhang, Anthony Atala, Robert J Stratta, Shay Soker
The present review illustrates the state of the art of regenerative medicine (RM) as applied to surgical diseases and demonstrates that this field has the potential to address some of the unmet needs in surgery. RM is a multidisciplinary field whose purpose is to regenerate in vivo or ex vivo human cells, tissues, or organs to restore or establish normal function through exploitation of the potential to regenerate, which is intrinsic to human cells, tissues, and organs. RM uses cells and/or specially designed biomaterials to reach its goals and RM-based therapies are already in use in several clinical trials in most fields of surgery...
May 2012: Annals of Surgery
Agnès Dupret-Bories, Philippe Schultz, Nihal Engin Vrana, Philippe Lavalle, Dominique Vautier, Christian Debry
This article documents experiments performed in ewes to design an artificial larynx. The artificial larynx is composed of a hollow, porous tube that elongates the trachea and is capped with a valve that acts as a laryngeal sphincter. Through an industrial collaboration, our team developed a porous biomaterial that can be colonized by cervical tissues. This biomaterial has been used in animals to replace part of the trachea, but it is meant to eventually substitute for laryngeal cartilage. The tracheal prosthesis is a hollow cylindrical tube composed of titanium microbeads...
2011: Journal of Rehabilitation Research and Development
Sandeep S Karajanagi, Gerardo Lopez-Guerra, Hyoungshin Park, James B Kobler, Marilyn Galindo, Jon Aanestad, Daryush D Mehta, Yoshihiko Kumai, Nicholas Giordano, Anthony d'Almeida, James T Heaton, Robert Langer, Victoria L M Herrera, William Faquin, Robert E Hillman, Steven M Zeitels
OBJECTIVES: Most cases of irresolvable hoarseness are due to deficiencies in the pliability and volume of the superficial lamina propria of the phonatory mucosa. By using a US Food and Drug Administration-approved polymer, polyethylene glycol (PEG), we created a novel hydrogel (PEG30) and investigated its effects on multiple vocal fold structural and functional parameters. METHODS: We injected PEG30 unilaterally into 16 normal canine vocal folds with survival times of 1 to 4 months...
March 2011: Annals of Otology, Rhinology, and Laryngology
Yoshiharu Kitani, Shin-Ichi Kanemaru, Hiroo Umeda, Atsushi Suehiro, Yo Kishimoto, Shigeru Hirano, Tatsuo Nakamura, Juichi Ito
OBJECTIVES: We previously reported that polypropylene mesh covered with collagen sponge is a useful material for the regeneration of the trachea and the cricoid cartilage. The aim of this study was to regenerate larynges after partial hemilaryngectomy with this new biomaterial. METHODS: A left partial hemilaryngectomy was performed on 12 adult beagles. The defect size was about 1.8 x 1.0 cm. Both sides of polypropylene mesh were coated with either 1% or 3% collagen sponge...
January 2011: Annals of Otology, Rhinology, and Laryngology
Philippe Schultz, Anne Charpiot, Dominique Vautier, Florence Guilleré, Christian Debry
OBJECTIVE: The aim of this work is to present requirements and actual solutions to produce a laryngeal prosthesis. METHOD: Data were collected after a literature review and in the light of our work in that field. RESULTS: The conception of an artificial larynx requires biocompatibility studies to find the ideal biomaterial capable of being integrated in cervical environment and upper airway tracts. A hollow tube extending the trachea, surrounded by cervical tissue, and covered with epithelium on the endoluminal part would allow connecting the trachea to the tongue base...
August 2010: Journal of Otolaryngology—Head & Neck Surgery
Victoria L M Herrera, Jason C Viereck, Gerardo Lopez-Guerra, Yoshihiko Kumai, James Kobler, Sandeep Karajanagi, Hyoungshin Park, Robert Hillman, Steven M Zeitels
OBJECTIVES/HYPOTHESIS: High-resolution imaging of vocal folds that distinguishes vocal fold (VF) layered microstructure and VF implants would provide a key experimental tool for translational research investigating biomaterial-based interventions to treat vocal fold scar. To establish proof of concept, we studied whether 11.7 Tesla (T) magnetic resonance (MR) microimaging provides the needed resolution to resolve vocal fold tissue architecture. STUDY DESIGN: We performed ex vivo MR microimaging of fixed ferret and canine larynges to determine whether changes in the layered architecture can be detected in the presence of scar and subsequent to biomaterial injections into the vocal folds...
November 2009: Laryngoscope
E A Kirasirova, F S Karimova
Posttraumatic stenosis of the larynx, cervical and upper choracic parts of the trachea was treated surgically using biomaterial (cartilage) alloplant and hemostatic material sergisel with an antibacterial effect. Cartilage implantation into the lateral tracheal walls was made in 10 patients, creation of the lateral and anterial walls of the larynx and trachea was made in 4 patients. Short before the cartilage placing in the tissues it was packed with material sergisel. Further adequate dilatation prosthetic reconstruction of the trachea for 3-4 months with application of silicon T-tube allowed complete decanulation of 7 patients (50%) -- they have undergone plastic surgery of the anterior tracheal wall...
2007: Vestnik Otorinolaringologii
Lígia Rodrigues, Ibrahim M Banat, José Teixeira, Rosário Oliveira
Total laryngectomy, a surgical treatment for extensive cancer of larynx, which alters swallowing and respiration in patients, is followed up with a surgical voice restoration procedure comprising tracheoesophageal puncture techniques with insertion of a "voice prosthesis" to improve successful voice rehabilitation. However, microbial colonization is a major drawback of these devices. Antimicrobials are usually used to prevent the colonization of silicone rubber voice prostheses by microorganisms. However, long-term medication induces the development of resistant strains with all associated risks and the development of alternative prophylactic and therapeutic agents, including probiotics and biosurfactants, have been suggested...
May 2007: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
D Rickert, A Lendlein, S Kelch, M A Moses, R-P Franke
INTRODUCTION: Using standard cell biological and biochemical experimental approaches we were able to test the ability of a particular polymer construct to support the adhesion, proliferation, and the cellular acitivity of pharyngeal cells. The delicate balance between Matrix Metalloproteinases (MMPs) and their endogenous inhibitors (Tissue Inhibitor of MMPs, TIMPs) have a decisive function in the remodeling of the extracellular matrix during cellular ingrowth. Novel polymeric biomaterials may be useful to develop new therapeutic options in head and neck surgery...
2005: Clinical Hemorheology and Microcirculation
An-ke Sun, Guo-xian Pei, Ping Hu, Jiang-rui Chen, Gao-hong Ren, Yu Zhang, Ba-sheng Hu, Yu Qin
OBJECTIVE: To explore the method of fabricating tissue engineered laryngeal cartilage. METHODS: The rib and articular cartilage of infant New Zealand white rabbits were harvested in sterile condition. The chondrocytes were separated by collagenase digestion and cultured in vitro for 3 passage. Serial steps of solution casting, extrusion molding and particulate leaching were used to make larynx-shaped biomaterial models with poly(3-hydroxybutyrate-co-3-hydroxyhexanoate, PHBHH)...
October 2004: Zhonghua Er Bi Yan Hou Ke za Zhi
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