keyword
https://read.qxmd.com/read/38547509/ordered-vacancies-as-sodium-ion-micropumps-in-cu-deficient-copper-indium-diselenide-to-enhance-sodium-storage
#1
JOURNAL ARTICLE
Fan Liu, Jingui Zong, Yazhan Liang, Mingzhe Zhang, Kepeng Song, Liwei Mi, Jinkui Feng, Shenglin Xiong, Baojuan Xi
Unordered vacancies engineered in host anode materials can't well maintain the uniform Na+ adsorbed and possibly render the local structural stress intense, resulting in electrode peeling and battery failure. Here, we firstly introduce the indium into Cu2 Se to achieve the formation of CuInSe2 . Next, ion extraction strategy is employed to fabricate Cu0.54 In1.15 Se2 enriched with ordered vacancies by the spontaneous formation of defect pairs. Such ordered defects, compared with unordered ones, can serve as myriad sodium ion micropumps evenly distributing in crystalline host to homogenize the adsorbed Na+ and the generated volumetric stress during the electrochemistry...
March 28, 2024: Advanced Materials
https://read.qxmd.com/read/38547429/transcription-factor-fvemyb117a-inhibits-axillary-bud-outgrowth-by-regulating-cytokinin-homeostasis-in-woodland-strawberry
#2
JOURNAL ARTICLE
Yafan Han, Minghao Qu, Zhongchi Liu, Chunying Kang
Shoot branching affects plant architecture. In strawberry (Fragaria L.), short branches (crowns) develop from dormant axillary buds to form inflorescences and flowers. While this developmental transition contributes greatly to perenniality and yield in strawberry, its regulatory mechanism remains unclear and understudied. In the woodland strawberry (Fragaria vesca), we identified and characterized two independent mutants showing more crowns. Both mutant alleles reside in FveMYB117a, a R2R3-MYB transcription factor gene highly expressed in shoot apical meristems, axillary buds and young leaves...
March 28, 2024: Plant Cell
https://read.qxmd.com/read/38547242/mycn-drives-oncogenesis-by-cooperating-with-the-histone-methyltransferase-g9a-and-the-wdr5-adaptor-to-orchestrate-global-gene-transcription
#3
JOURNAL ARTICLE
Zhihui Liu, Xiyuan Zhang, Man Xu, Jason J Hong, Amanda Ciardiello, Haiyan Lei, Jack F Shern, Carol J Thiele
MYCN activates canonical MYC targets involved in ribosome biogenesis, protein synthesis, and represses neuronal differentiation genes to drive oncogenesis in neuroblastoma (NB). How MYCN orchestrates global gene expression remains incompletely understood. Our study finds that MYCN binds promoters to up-regulate canonical MYC targets but binds to both enhancers and promoters to repress differentiation genes. MYCN binding also increases H3K4me3 and H3K27ac on canonical MYC target promoters and decreases H3K27ac on neuronal differentiation gene enhancers and promoters...
March 28, 2024: PLoS Biology
https://read.qxmd.com/read/38547221/does-attitude-importance-moderate-the-effects-of-person-first-language-a-registered-report
#4
JOURNAL ARTICLE
Sandy Schumann, Hazem Zohny
Previous research has demonstrated that exposure to outgroup descriptions that use person-first, as compared to identity-first, language can attenuate negative stereotypes or prejudice and enhance support for policies that seek to advance outgroup rights. However, those benefits of person-first language may not apply to all social groups equally. The present study examines a boundary condition of the effects of person-first language. Specifically, we postulate that person-first language reduces the stigmatization of outgroups to a lesser degree if individuals hold more important negative attitudes towards the respective communities...
2024: PloS One
https://read.qxmd.com/read/38547155/enhanced-amygdala-anterior-cingulate-white-matter-structural-connectivity-in-sahaja-yoga-meditators
#5
JOURNAL ARTICLE
Oscar Perez-Diaz, Daylín Góngora, José L González-Mora, Katya Rubia, Alfonso Barrós-Loscertales, Sergio Elías Hernández
OBJECTIVE: To study the white matter connections between anterior cingulate cortex, anterior insula and amygdala as key regions of the frontal-limbic network that have been related to meditation. DESIGN: Twenty experienced practitioners of Sahaja Yoga Meditation and twenty nonmeditators matched on age, gender and education level, were scanned using Diffusion Weighted Imaging, using a 3T scanner, and their white matter connectivity was compared using diffusion tensor imaging analyses...
2024: PloS One
https://read.qxmd.com/read/38547144/enhancing-rural-b-b-management-through-machine-learning-and-evolutionary-game-a-case-study-of-rural-revitalization-in-yunnan-china
#6
JOURNAL ARTICLE
Wiseong Jin, Kwisik Min, Xufang Hu, Shengchao Li, Xueqin Wang, Bodong Song, Chengmeng Li
The rural B&B industry is a key component of rural tourism, local economic development, and the wider rural revitalization strategy. Despite the abundance of tourism resources in Yunnan, the B&B sector faces significant challenges. It is therefore imperative to accurately identify the most pressing issues within the current B&B industry and formulate appropriate solutions to advance Yunnan's rural revitalization efforts. This study uses recent reviews of rural B&Bs on Ctrip.com and employs machine learning techniques, including Bert, CNN, LSTM, and GRU, to identify the key management challenges currently facing Yunnan's rural B&B industry...
2024: PloS One
https://read.qxmd.com/read/38547137/balancing-the-uncertain-and-unpredictable-nature-of-possible-zoonotic-disease-transmission-with-the-value-placed-on-animals-findings-from-a-qualitative-study-in-guinea
#7
JOURNAL ARTICLE
Tilly A Gurman, Kendela Diallo, Elizabeth Larson, Kathryn Sugg, Natalie Tibbels
Zoonoses, or diseases that pass between animals and humans, represent a major threat to global health and global economies. In Guinea, zoonotic diseases (e.g. rabies, Lassa fever) have been at the forefront due to recent outbreaks and government priorities. Much like many other diseases, zoonotic disease prevention demands a thorough and culturally nuanced understanding of the factors that influence preventive behaviors. To gain this knowledge and enhance risk communication for priority zoonotic diseases, this qualitative study conducted focus group discussions, in-depth interviews, and observations in three Guinean prefectures...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38547133/urban-public-services-and-fertility-intentions-of-internal-migrants-in-china
#8
JOURNAL ARTICLE
Sichen Liu, Quanling Cai, Mingxing Wang, Kaisheng Di
As China continues to implement its progressive fertility promotion policy, there has been a drastic decline in the fertility rate. Given that the migrant population constitutes more than a quarter of China's total population, enhancing the willingness of this demographic to have additional children through policy-guided urban public services is pivotal for optimizing China's population development strategy. This study analyzes the influence of urban public services on the reproductive intentions of the migrant population, utilizing data from 110,667 migrant families with one child, drawn from China's Migrant Population Dynamic Monitoring data in 2016 and 2018...
2024: PloS One
https://read.qxmd.com/read/38547058/nsun5-tet2-directed-chromatin-associated-rna-modification-of-5-methylcytosine-to-5-hydroxymethylcytosine-governs-glioma-immune-evasion
#9
JOURNAL ARTICLE
Ruixin Wu, Chunming Sun, Xi Chen, Runyue Yang, Yuxuan Luan, Xiang Zhao, Panpan Yu, Rongkui Luo, Yingyong Hou, Ruotong Tian, Shasha Bian, Yuli Li, Yinghua Dong, Qian Liu, Weiwei Dai, Zhuoyang Fan, Rucheng Yan, Binyang Pan, Siheng Feng, Jing Wu, Fangzhen Chen, Changle Yang, Hanlin Wang, Haochen Dai, Minfeng Shu
Malignant glioma exhibits immune evasion characterized by highly expressing the immune checkpoint CD47. RNA 5-methylcytosine(m5C) modification plays a pivotal role in tumor pathogenesis. However, the mechanism underlying m5C-modified RNA metabolism remains unclear, as does the contribution of m5C-modified RNA to the glioma immune microenvironment. In this study, we demonstrate that the canonical 28SrRNA methyltransferase NSUN5 down-regulates β-catenin by promoting the degradation of its mRNA, leading to enhanced phagocytosis of tumor-associated macrophages (TAMs)...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38547055/the-muc1-hif-1%C3%AE-signaling-axis-regulates-pancreatic-cancer-pathogenesis-through-polyamine-metabolism-remodeling
#10
JOURNAL ARTICLE
Divya Murthy, Kuldeep S Attri, Voddu Suresh, Girish H Rajacharya, Carlos A Valenzuela, Ravi Thakur, Junzhang Zhao, Surendra K Shukla, Nina V Chaika, Drew LaBreck, Chinthalapally V Rao, Michael A Hollingsworth, Kamiya Mehla, Pankaj K Singh
Dysregulation of polyamine metabolism has been implicated in cancer initiation and progression; however, the mechanism of polyamine dysregulation in cancer is not fully understood. In this study, we investigated the role of MUC1, a mucin protein overexpressed in pancreatic cancer, in regulating polyamine metabolism. Utilizing pancreatic cancer patient data, we noted a positive correlation between MUC1 expression and the expression of key polyamine metabolism pathway genes. Functional studies revealed that knockdown of spermidine/spermine N1-acetyltransferase 1 ( SAT1 ), a key enzyme involved in polyamine catabolism, attenuated the oncogenic functions of MUC1, including cell survival and proliferation...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38546975/insulin-transferrin-selenium-promote-formation-of-tissue-engineered-vascular-grafts-in-early-stage-of-culture
#11
JOURNAL ARTICLE
Xuheng Sun, Nannan Wang, Hongjing Jiang, Qing Liu, Cong Xiao, Jianyi Xu, Yindi Wu, Jingyi Mei, Shuting Wu, Zhanyi Lin
To create tissue-engineered vascular grafts (TEVGs) in vitro, vascular smooth muscle cells (VSMCs) must function effectively and produce sufficient extracellular matrix (ECM) in a three-dimensional space. In this study, we investigated whether the addition of insulin-transferrin-selenium (ITS), a medium supplement, could enhance TEVG formation. PGA fabric was used as the scaffold, and 1% ITS was added to the medium. After two weeks, the tissues were examined using electron microscopy and staining. The ITS group exhibited a denser structure and increased collagen production...
March 28, 2024: Preparative Biochemistry & Biotechnology
https://read.qxmd.com/read/38546732/surface-modification-of-ultrasonic-cavitation-by-surfactants-improves-detection-sensitivity-of-%C3%AE-synuclein-amyloid-seeds
#12
JOURNAL ARTICLE
Kichitaro Nakajima, Tomoki Ota, Hajime Toda, Keiichi Yamaguchi, Yuji Goto, Hirotsugu Ogi
The rapid amplification and sensitive detection of α-synuclein (αSyn) seeds is an efficient approach for the early diagnosis of Parkinson's disease. Ultrasonication stands out as a promising method for the rapid amplification of αSyn seeds because of its robust fibril fragmentation capability. However, ultrasonication also induces the primary nucleation of αSyn monomers, deteriorating the seed detection sensitivity by generating seed-independent fibrils. In this study, we show that an addition of surfactants to the αSyn monomer solution during αSyn seed detection under ultrasonication remarkably improves the detection sensitivity of the αSyn seeds by a factor of 100-1000...
March 28, 2024: ACS Chemical Neuroscience
https://read.qxmd.com/read/38546714/social-media-use-in-dermatology-in-turkey-challenges-and-tips-for-patient-health
#13
JOURNAL ARTICLE
Ayse Serap Karadag, Basak Kandi, Berna Sanlı, Hande Ulusal, Hasan Basusta, Seray Sener, Sinem Calıka
Social media has established its place in our daily lives, especially with the advent of the COVID-19 pandemic. It has become the leading source of information for dermatological literacy on various topics, ranging from skin diseases to everyday skincare and cosmetic purposes in the present digital era. Accumulated evidence indicates that accurate medical content constitutes only a tiny fraction of the exponentially growing dermatological information on digital platforms, highlighting an unmet patient need for access to evidence-based information on social media...
March 28, 2024: JMIR dermatology
https://read.qxmd.com/read/38546591/a-randomized-controlled-trial-examining-the-effect-of-camp-hope-tennessee-on-youth-functioning-results-from-a-pilot-study
#14
JOURNAL ARTICLE
Amanda J Hasselle, Kathryn H Howell, Anissa Garza, Kari N Thomsen, Hannah C Gilliam
OBJECTIVE: Family violence can negatively affect youth's psychosocial functioning. Strengths-based interventions may enhance positive youth functioning among youth experiencing adversity, but little is known about the effectiveness of camp-based interventions for youth exposed to family violence. The current study examined the effectiveness of Camp HOPE Tennessee in promoting multidimensional well-being and school engagement among youth exposed to family violence. METHOD: This pilot study employed a nonmasked, parallel randomized controlled design...
March 28, 2024: Psychological Trauma: Theory, Research, Practice and Policy
https://read.qxmd.com/read/38546432/antibiotic-prescription-sources-and-use-among-under-5-children-with-fever-cough-in-sub-saharan-africa
#15
JOURNAL ARTICLE
Getayeneh A Tesema, Godness K Biney, Vicky Q Wang, Edward K Ameyaw, Sanni Yaya
BACKGROUND: Childhood febrile illness is among the leading causes of hospital admission for children <5 y of age in sub-Saharan Africa (SSA). Antibiotics have played a pivotal role in enhancing health outcomes, especially for children <5 y of age. Antibiotics prescription pattern evidence exists for SSA, however, prescription sources (either from qualified or unqualified sources) and use among children with fever or cough have not been explored. Thus the present study assessed antibiotic prescription sources and use among children <5 y of age with fever and cough in SSA...
March 28, 2024: International Health
https://read.qxmd.com/read/38546410/interface-targeting-carrier-catalytic-integrated-design-contributing-to-lithium-dihalide-rich-sei-toward-high-interface-stability-for-long-life-solid-state-lithium-metal-batteries
#16
JOURNAL ARTICLE
Xuan Yi Zhou, Fen Fen Huang, Xue Dong Zhang, Biao Zhang, Ying Jie Cui, Ze Hua Wang, Qiong Yang, Zeng Sheng Ma, Jun Liu
The generation of solid electrolyte interphase (SEI) largely determines the comprehensive performance of all-solid-state batteries. Herein, a novel "carrier-catalytic" integrated design is strategically exploited to in situ construct a stable LiF-LiBr rich SEI by improving the electron transfer kinetics to accelerate the bond-breaking dynamics. Specifically, the high electron transport capacity of Br-TPOM skeleton increases the polarity of C-Br, thus promoting the generation of LiBr...
March 28, 2024: Angewandte Chemie
https://read.qxmd.com/read/38546386/hepatitis-b-virus-mediated-m6a-demethylation-increases-hepatocellular-carcinoma-stemness-and-immune-escape
#17
JOURNAL ARTICLE
Yuting Meng, Zheyue Shu, Xueyao Wang, Liang Hong, Baohua Wang, Jingjing Jiang, Kangxin He, Qingyi Cao, Fan Shi, Hai Wang, Lan Gong, Hongyan Diao
Hepatitis B viral (HBV) persistent infection plays a significant role in hepatocellular carcinoma (HCC) tumorigenesis. Many studies have revealed the pivotal roles of N6-methyladenosine (m6A) in multiple cancers, while the regulatory mechanism in stemness maintenance of HBV persistent infection-related HCC remains elusive. Here, we demonstrated that the level of m6A modification was downregulated by HBV in HBV-positive HCC, through enhanced stability of ALKBH5 mRNA. More specifically, we also identified that ALKBH5 mRNA was functionally required for the stemness maintenance and self-renewal in the HBV-positive HCC, but dispensable in HBV-negative HCC...
March 28, 2024: Molecular Cancer Research: MCR
https://read.qxmd.com/read/38546355/tuning-catalytic-activity-of-co2-hydrogenation-to-c1-product-via-metal-support-interaction-over-metal-metal-oxide-supported-catalysts
#18
JOURNAL ARTICLE
Weiwei Wang, Xiaoyu Zhang, Shujia Weng, Chong Peng
The metal supported catalysts are emerging catalysts that are receiving a lot of attention in CO2 hydrogenation to C1 products. Numerous experiments have demonstrated that the support (usually an oxide) is crucial for the catalytic performance. The support metal oxides are used to aid in the homogeneous dispersion of metal particles, prevent agglomeration, and control morphology owing to the metal support interaction (MSI). MSI can efficiently optimize the structural and electronic properties of catalysts and tune the conversion of key reaction intermediates involved in CO2 hydrogenation, thereby enhancing the catalytic performance...
March 28, 2024: ChemSusChem
https://read.qxmd.com/read/38546328/identifying-the-suite-of-genes-central-to-swimming-in-the-biocontrol-bacterium-pseudomonas-protegens-pf-5
#19
JOURNAL ARTICLE
B K Fabian, C Foster, A Asher, K A Hassan, I T Paulsen, S G Tetu
Swimming motility is a key bacterial trait, important to success in many niches. Biocontrol bacteria, such as Pseudomonas protegens Pf-5, are increasingly used in agriculture to control crop diseases, where motility is important for colonization of the plant rhizosphere. Swimming motility typically involves a suite of flagella and chemotaxis genes, but the specific gene set employed for both regulation and biogenesis can differ substantially between organisms. Here we used transposon-directed insertion site sequencing (TraDIS), a genome-wide approach, to identify 249 genes involved in P...
March 2024: Microbial Genomics
https://read.qxmd.com/read/38546280/accelerated-failure-time-modeling-of-in-lane-street-hawkers-lane-entry-and-exit-behaviors-at-signalized-intersections
#20
JOURNAL ARTICLE
Philip Kofi Alimo, Lawrencia Agen-Davis, Ling Wang, Wanjing Ma
In-lane street hawking is the intermittent entry of signalized intersections by traders to sell groceries to drivers and passengers. Studies have shown that hawkers get exposed to traffic injuries but the lack of quantitative analysis of their lane entry and exit behaviors in signalized intersections makes it difficult to improve traffic safety. This study analyzes the significant predictors of in-lane street hawkers' (1) lane entry within 30 s after the red signal illumination, (2) lane exit within 30 s after the green signal illumination, and (3) probability of getting injuries during the green signal time...
March 28, 2024: International Journal of Injury Control and Safety Promotion
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