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https://www.readbyqxmd.com/read/29036760/the-effects-of-downhill-and-uphill-exercise-training-on-osteogenesis-related-factors-in-ovariectomy-induced-bone-loss
#1
Yun-Seok Kang, Chun-Ho Kim, Jeong-Seok Kim
PURPOSE: Recent evidence suggests that regular exercise training plays a decisive role in maintaining homeostasis and promoting muscle and skeletal formation. However, the effect of downhill exercise training on osteogenesis-related factors is not well understood. METHODS: Thus, we investigated the effect of uphill and downhill training on ovariectomy (OVX)-induced bone loss. After ovary removal, the exercise method performed included uphill (16 m/min, +15°) and downhill training (16 m/min, -15°) for 60 min/day and 5 days/week, respectively, for 8 weeks...
September 30, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/29036666/do-israeli-health-promoting-schools-contribute-to-students-healthy-eating-and-physical-activity-habits
#2
Samah Hayek, Riki Tessler, Shiran Bord, Ronit Endevelt, Carmit Satran, Irit Livne, Mohammed Khatib, Yosi Harel-Fisch, Orna Baron-Epel
The Israeli Health Promoting School Network (HPSN) is actively committed to enhancing a healthy lifestyle for the entire school population. This study aimed to explore the contribution of school participation in the HPSN and students' individual characteristics to healthy eating and physical activity habits among Israeli school children aged 10-12 years. A cross-sectional survey was conducted among 4166 students in grades 4-6 from 28 schools. The schools were selected from a sample of HPSN affiliated and non-HPSN schools...
October 4, 2017: Health Promotion International
https://www.readbyqxmd.com/read/29036586/epigenetic-mechanisms-underlie-the-crosstalk-between-growth-factors-and-a-steroid-hormone
#3
Yehoshua Enuka, Morris E Feldman, Animesh Chowdhury, Swati Srivastava, Moshit Lindzen, Aldema Sas-Chen, Renaud Massart, David Cheishvili, Matthew J Suderman, Yoav Zaltsman, Chiara A Mazza, Kirti Shukla, Cindy Körner, Noa Furth, Mattia Lauriola, Moshe Oren, Stefan Wiemann, Moshe Szyf, Yosef Yarden
Crosstalk between growth factors (GFs) and steroid hormones recurs in embryogenesis and is co-opted in pathology, but underlying mechanisms remain elusive. Our data from mammary cells imply that the crosstalk between the epidermal GF and glucocorticoids (GCs) involves transcription factors like p53 and NF-κB, along with reduced pausing and traveling of RNA polymerase II (RNAPII) at both promoters and bodies of GF-inducible genes. Essentially, GCs inhibit positive feedback loops activated by GFs and stimulate the reciprocal inhibitory loops...
September 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036463/multiple-links-between-shade-avoidance-and-auxin-networks
#4
María José Iglesias, Romina Sellaro, Matias D Zurbriggen, Jorge José Casal
Auxin has emerged as a key player in the adjustment of plant morphology to the challenge imposed by variable environmental conditions. Shade-avoidance responses, including the promotion of stem and petiole growth, leaf hyponasty, and the inhibition of branching, involve an intimate connection between light and auxin signalling. Low activity of photo-sensory receptors caused by the presence of neighbouring vegetation enhances the activity of PHYTOCHROME INTERACTING FACTORs (PIFs), which directly promote the expression of genes involved in auxin biosynthesis, conjugation, transport, perception, and signalling...
September 27, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29036438/a-selective-sphingosine-1-phosphate-receptor-1-agonist-sew-2871-aggravates-gastric-cancer-by-recruiting-myeloid-derived-suppressor-cells
#5
Yujing Zhou, Feng Guo
The immune status of tumor microenvironment in gastric cancer is poorly understood, which limits the development of novel strategies in this field. Sphingosine-1-phosphate (S1P) acts as an immune modulator, but the role of S1P in gastric cancer is elusive. Here, we aim to investigate S1P receptor 1 (S1P1)-mediated effect of S1P in gastric cancer. We generated a xenograft mouse model and used SEW-2871, a S1P1 specific agonist to activate S1P1 signaling. Tumor-infiltrating lymphocytes (TILs) were isolated and analyzed using flow cytometry...
October 3, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/29036381/project-echo-telementoring-intervention-for-managing-chronic-pain-in-primary-care-insights-from-a-qualitative-study
#6
Leslie Carlin, Jane Zhao, Ruth Dubin, Paul Taenzer, Hannah Sidrak, Andrea Furlan
Objective: Family physicians in Canada receive little training in chronic pain management; concomitantly, they face increasing pressure to reduce their prescribing of opioids. Project ECHO Ontario Chronic Pain/Opioid Stewardship (ECHO) is a telementoring intervention for primary care practitioners that enhances their pain management skills. This qualitative study reports participants' experiences and assessment of ECHO. Design: An opportunistic sample of multidisciplinary primary care providers attending one of three residential weekend workshops participated in focus group discussions...
September 27, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29036346/opbp-is-a-new-architectural-insulator-protein-required-for-ribosomal-gene-expression
#7
Nikolay Zolotarev, Oksana Maksimenko, Olga Kyrchanova, Elena Sokolinskaya, Igor Osadchiy, Charles Girardot, Artem Bonchuk, Lucia Ciglar, Eileen E M Furlong, Pavel Georgiev
A special class of poorly characterized architectural proteins is required for chromatin topology and enhancer-promoter interactions. Here, we identify Opbp as a new Drosophila architectural protein, interacting with CP190 both in vivo and in vitro. Opbp binds to a very restrictive set of genomic regions, through a rare sequence specific motif. These sites are co-bound by CP190 in vivo, and generally located at bidirectional promoters of ribosomal protein genes. We show that Opbp is essential for viability, and loss of opbp function, or destruction of its motif, leads to reduced ribosomal protein gene expression, indicating a functional role in promoter activation...
September 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036198/the-homeodomain-interacting-protein-kinase-hpk-1-preserves-protein-homeostasis-and-longevity-through-master-regulatory-control-of-the-hsf-1-chaperone-network-and-torc1-restricted-autophagy-in-caenorhabditis-elegans
#8
Ritika Das, Justine A Melo, Manjunatha Thondamal, Elizabeth A Morton, Adam B Cornwell, Beresford Crick, Joung Heon Kim, Elliot W Swartz, Todd Lamitina, Peter M Douglas, Andrew V Samuelson
An extensive proteostatic network comprised of molecular chaperones and protein clearance mechanisms functions collectively to preserve the integrity and resiliency of the proteome. The efficacy of this network deteriorates during aging, coinciding with many clinical manifestations, including protein aggregation diseases of the nervous system. A decline in proteostasis can be delayed through the activation of cytoprotective transcriptional responses, which are sensitive to environmental stress and internal metabolic and physiological cues...
October 16, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29036025/the-fate-of-the-adipose-derived-stromal-cells-during-angiogenesis-and-adipogenesis-after-cell-assisted-lipotransfer
#9
Ki Yong Hong, Sangjun Yim, Hyun Jung Kim, Ung Sik Jin, SooA Lim, SuRak Eo, Hak Chang, Kyung Won Minn
BACKGROUND: Cell-assisted lipotransfer (CAL) is a process in which fat grafting is supplemented with autologous adipose-derived stromal cells (ASCs). Since the efficacy of the technique was demonstrated, studies have focused on the mechanism by which CAL enhances the rate of graft survival. However, the microenvironmental changes in donor and recipient tissue associated with CAL remain unclear. METHODS: We introduced an animal model of CAL using two different transgenic reporter mice...
October 12, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29035967/pediatric-clinical-handover-a-best-practice-implementation-project
#10
Zhuowen Yu, Yuxia Zhang, Ying Gu, Xiaofeng Xu, Alexa McArthur
BACKGROUND: Communication of information between and among healthcare providers is an essential element of patient care. Poor clinical handover has been associated with inaccurate clinical assessment and diagnosis, delays in diagnosis, medication errors and decreased patient satisfaction. Effective and efficient transition of patient care information requires an evidence-based handover approach. OBJECTIVES: The aim of this evidence implementation project was to make a contribution to promote evidence-based practice in clinical handover in a pediatric setting and thereby enhance patient safety and service delivery...
October 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29035831/the-effects-of-novel-chitosan-targeted-gemcitabine-nanomedicine-mediating-cisplatin-on-epithelial-mesenchymal-transition-invasion-and-metastasis-of-pancreatic-cancer-cells
#11
Haibo Yu, Hongliang Song, Jun Xiao, Haichuan Chen, Xiaodan Jin, Xizhou Lin, Bujian Pan, Wu Ji
OBJECTIVE: The study aimed to evaluate the effects involved with the novel chitosan gemcitabine (Gem) nanoparticles mediating cisplatin (DDP) on epithelial mesenchymal transition (EMT), invasion and metastasis of pancreatic cancer (PC) cells. METHODS: A total of 62 healthy purebred BALB/C of specific-pathogen free (SPF) female nude mice were recruited and a SW1990 cell line was subsequently cultured. A heterotopic xenograft tumor model was constructed. After determining the optimal drug concentration, the nude mice were assigned into the control, glycol chitosan (GC)-Gem microsphere, antibody Complex (Abc)-GC-Gem and Abc-GC-Gem microsphere+DDP groups (n=8 in each group)...
October 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29035745/bio-functionalization-of-grade-v-titanium-alloy-with-type-i-human-collagen-for-enhancing-and-promoting-human-periodontal-fibroblast-cell-adhesion-an-in-vitro-study
#12
Jitendra Sharan, Veena Koul, Amit K Dinda, Om P Kharbanda, Shantanu V Lale, Ritu Duggal, Monu Mishra, Govind Gupta, Manoj P Singh
Surface modification of medical grade V titanium alloy (Ti-6Al-4V) with biomolecules is an important and vital step for tailoring it for various biomedical applications. Present study investigates theinfluence of type I human collagen (T1HC) bio-conjugation through a three stage process. Polished grade V titanium alloy discs were functionalizedwith free OH group by means of controlled heat and alkali treatment followed by coating of 3-aminopropyltriethoxy (APTES) silane couplingagent. T1HC were bio-conjugated through 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride N-hydroxysuccinimide (EDCNHS)coupling reaction...
October 9, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29035572/maintaining-and-enhancing-diversity-of-sampled-protein-conformations-in-robotics-inspired-methods
#13
Jayvee R Abella, Mark Moll, Lydia E Kavraki
The ability to efficiently sample structurally diverse protein conformations allows one to gain a high-level view of a protein's energy landscape. Algorithms from robot motion planning have been used for conformational sampling, and several of these algorithms promote diversity by keeping track of "coverage" in conformational space based on the local sampling density. However, large proteins present special challenges. In particular, larger systems require running many concurrent instances of these algorithms, but these algorithms can quickly become memory intensive because they typically keep previously sampled conformations in memory to maintain coverage estimates...
October 16, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/29035389/-mcc-protein-interacts-with-e-cadherin-and-%C3%AE-catenin-strengthening-cell-cell-adhesion-of-hct116-colon-cancer-cells
#14
F A Benthani, D Herrmann, P N Tran, L Pangon, M C Lucas, A H Allam, N Currey, S Al-Sohaily, M Giry-Laterriere, J Warusavitarne, P Timpson, M R J Kohonen-Corish
E-cadherin and β-catenin are key proteins that are essential in the formation of the epithelial cell layer in the colon but their regulatory pathways that are disrupted in cancer metastasis are not completely understood. Mutated in colorectal cancer (MCC) is a tumour suppressor gene that is silenced by promoter methylation in colorectal cancer and particularly in patients with increased lymph node metastasis. Here, we show that MCC methylation is found in 45% of colon and 24% of rectal cancers and is associated with proximal colon, poorly differentiated, circumferential and mucinous tumours as well as increasing T stage and larger tumour size...
October 16, 2017: Oncogene
https://www.readbyqxmd.com/read/29035388/a-novel-her2-gene-body-enhancer-contributes-to-her2-expression
#15
Q Liu, M V Kulak, N Borcherding, P K Maina, W Zhang, R J Weigel, H H Qi
The transcriptional regulation of the human epidermal growth factor receptor-2 (HER2) contributes to an enhanced HER2 expression in HER2-positive breast cancers with HER2 gene amplification and HER2-low or HER2-negative breast cancers following radiotherapy or endocrine therapy, and this drives tumorigenesis and the resistance to therapy. Epigenetic mechanisms are critical for transcription regulation, however, such mechanisms in the transcription regulation of HER2 are limited to the involvement of tri-methylated histone 3 lysine 4 (H3K4me3) and acetylated histone 3 lysine 9 (H3K9ac) at the HER2 promoter region...
October 16, 2017: Oncogene
https://www.readbyqxmd.com/read/29035375/upregulation-of-the-actin-cytoskeleton-via-myocardin-leads-to-increased-expression-of-type-1-collagen
#16
Zengdun Shi, Don C Rockey
Liver fibrosis, a model wound healing system, is characterized by excessive deposition of extracellular matrix (ECM) in the liver. Although many fibrogenic cell types may express ECM, the hepatic stellate cell (HSC) is currently considered to be the major effector. HSCs transform into myofibroblast-like cells, also known as hepatic myofibroblasts in a process known as activation; this process is characterized in particular by de novo expression of smooth muscle alpha actin (SM α-actin) and type 1 collagen...
October 16, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29035281/young-endothelial-cells-revive-aging-blood
#17
Vivian Y Chang, Christina M Termini, John P Chute
The hematopoietic system declines with age, resulting in decreased hematopoietic stem cell (HSC) self-renewal capacity, myeloid skewing, and immune cell depletion. Aging of the hematopoietic system is associated with an increased incidence of myeloid malignancies and a decline in adaptive immunity. Therefore, strategies to rejuvenate the hematopoietic system have important clinical implications. In this issue of the JCI, Poulos and colleagues demonstrate that infusions of bone marrow (BM) endothelial cells (ECs) from young mice promoted HSC self-renewal and restored immune cell content in aged mice...
October 16, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29035278/hdac3-regulates-lymphovenous-and-lymphatic-valve-formation
#18
Harish P Janardhan, Zachary J Milstone, Masahiro Shin, Nathan D Lawson, John F Keaney, Chinmay M Trivedi
Lymphedema, the most common lymphatic anomaly, involves defective lymphatic valve development; yet the epigenetic modifiers underlying lymphatic valve morphogenesis remain elusive. Here, we showed that during mouse development, the histone-modifying enzyme histone deacetylase 3 (Hdac3) regulates the formation of both lymphovenous valves, which maintain the separation of the blood and lymphatic vascular systems, and the lymphatic valves. Endothelium-specific ablation of Hdac3 in mice led to blood-filled lymphatic vessels, edema, defective lymphovenous valve morphogenesis, improper lymphatic drainage, defective lymphatic valve maturation, and complete lethality...
October 16, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29034970/oral-health-of-older-residents-in-care-and-community-dwellers-nursing-implications
#19
J S Choi, Y J Yi, L R Donnelly
BACKGROUND: Poor oral health is associated with a reduced quality of life and serious illnesses. Consequently, nurses need to be more aware of oral health to improve the general health of residents in care. AIM: To evaluate and compare oral health behaviours and levels of salivary haemoglobin and dental biofilm acidogenicity, which can be used to evaluate oral disease activity, between residents and community dwellers in South Korea. METHODS: This cross-sectional study included 133 participants: 64 residents and 69 community dwellers...
October 16, 2017: International Nursing Review
https://www.readbyqxmd.com/read/29034634/-construction-and-characterization-of-type-iii-secretion-system-of-attenuated-salmonella-typhimurium
#20
Chuan Yu, Chongkai Zhai, Chengshui Liao, Zuhua Yu, Lei He, Yanyan Jia, Jing Li, Chunjie Zhang, Xiangchao Cheng
In order to develop a recombinant attenuated Salmonella typhimurium as oral live vaccine vector, we constructed recombinant plasmid pYA-sopENt100 by replacing the trc promoter with the sopE promoter and secretion signal sequence sopENt100 of Salmonella typhimurium on the basis of plasmid pYA3493. Then, the complementary plasmid pYA-sopENt100 was transformed into ΔcrpΔasdSL1344 by electroporation to generate attenuated Salmonella typhimurium type III secretion system ΔcrpΔasdSL1344 (pYA-sopENt100). We further characterized ΔcrpΔasdSL1344 (pYA-sopENt100)...
December 25, 2016: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
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