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https://www.readbyqxmd.com/read/28822335/specificity-protein-1-modulated-superoxide-dismutase-2-enhances-temozolomide-resistance-in-glioblastoma-which-is-independent-of-o-6-methylguanine-dna-methyltransferase
#1
Kwang-Yu Chang, Tsung-I Hsu, Che-Chia Hsu, Shan-Yin Tsai, Jr-Jiun Liu, Shao-Wen Chou, Ming-Sheng Liu, Jing-Ping Liou, Chiung-Yuan Ko, Kai-Yun Chen, Jan-Jong Hung, Wen-Chang Chang, Cheng-Keng Chuang, Tzu-Jen Kao, Jian-Ying Chuang
Acquisition of temozolomide (TMZ) resistance is a major factor leading to the failure of glioblastoma (GBM) treatment. The exact mechanism by which GBM evades TMZ toxicity is not always related to the expression of the DNA repair enzyme O(6)-methylguanine-DNA methyltransferase (MGMT), and so remains unclear. In this study, TMZ-resistant variants derived from MGMT-negative GBM clinical samples and cell lines were studied, revealing there to be increased specificity protein 1 (Sp1) expression associated with reduced reactive oxygen species (ROS) accumulation following TMZ treatment...
August 12, 2017: Redox Biology
https://www.readbyqxmd.com/read/28822194/-effect-of-oridonin-on-apoptosis-and-intracellular-reactive-oxygen-species-level-in-triple-negative-breast-cancer-mda-mb-231-cells
#2
Qi Qi, Pei Zhang, Qi-Xiang Li, Qiong Pan, Hai-Lun Zheng, Su-Rong Zhao
Oridonin, which is an ent-kaurene diterpenoid isolated from traditional Chinese medicine Rabdosia rubescens, displays various bioactivities, including anti-inflammation, anti-bacteria and anti-tumor. This study aimed to investigate the effect of oridonin on apoptosis of triple-negative breast cancer MDA-MB-231 cells and its underlying mechanisms. The inhibitory effect of oridonin on proliferation of MDA-MB-231 cells was measured by MTT assay; Apoptosis was analyzed by flow cytometry with PI staining and Annexin V-FITC/PI staining; Intracellular reactive oxygen species (ROS) level was determined by ROS detection kit, and expressions of PARP, Bcl-2, caspase-3 were analyzed by Western blot...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28822061/co-ultramicronized-palmitoylethanolamide-luteolin-facilitates-the-development-of-differentiating-and-undifferentiated-rat-oligodendrocyte-progenitor-cells
#3
Stephen D Skaper, Massimo Barbierato, Laura Facci, Mila Borri, Gabriella Contarini, Morena Zusso, Pietro Giusti
Oligodendrocytes, the myelin-producing cells of the central nervous system (CNS), have limited capability to bring about repair in chronic CNS neuroinflammatory demyelinating disorders such as multiple sclerosis (MS). MS lesions are characterized by a compromised pool of undifferentiated oligodendrocyte progenitor cells (OPCs) unable to mature into myelin-producing oligodendrocytes. An attractive strategy may be to replace lost OLs and/or promote their maturation. N-palmitoylethanolamine (PEA) is an endogenous fatty acid amide signaling molecule with anti-inflammatory and neuroprotective actions...
August 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28821879/musashi-1-enhances-glioblastoma-cell-migration-and-cytoskeletal-dynamics-through-translational-inhibition-of-tensin3
#4
Hsiao-Yun Chen, Liang-Ting Lin, Mong-Lien Wang, Benoit Laurent, Chih-Hung Hsu, Chih-Ming Pan, Wan-Ru Jiang, Pau-Yuan Chen, Hsin-I Ma, Yi-Wei Chen, Pin-I Huang, Arthur Chiou, Shih-Hwa Chiou
The RNA-binding protein Musashi-1 (MSI1) exerts essential roles in multiple cellular functions, such as maintenance of self-renewal and pluripotency of stem cells. MSI1 overexpression has been observed in several tumor tissues, including glioblastoma (GBM), and is considered as a well-established marker for tumor metastasis and recurrence. However, the molecular mechanisms by which MSI1 regulates cell migration are still undetermined. Here we reported that MSI1 alters cell morphology, promotes cell migration, and increases viscoelasticity of GBM cells...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821875/convenient-and-effective-icgylation-of-magnetic-nanoparticles-for-biomedical-applications
#5
Hye Sun Park, Jongwoo Kim, Mi Young Cho, Hyunseung Lee, Sang Hwan Nam, Yung Doug Suh, Kwan Soo Hong
Nanoprobes used for biomedical applications usually require surface modifications with amphiphilic surfactants or inorganic coating materials to enhance their biocompatibility. We proposed a facile synthetic approach for the phase transfer of hydrophobic magnetic nanoparticles by the direct adherence of fluorescent probes, without any chemical modifications, for use as a magnetic resonance (MR)/near-infrared (NIR) fluorescence bimodal imaging contrast agent. Indocyanine green (ICG) was used not only as an optical component for NIR imaging, but also as a surfactant for phase transfer with no superfluous moiety: we therefore called the process "ICGylation"...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821775/atf3-negatively-regulates-cellular-antiviral-signaling-and-autophagy-in-the-absence-of-type-i-interferons
#6
Vikas Sood, Kiran Bala Sharma, Vishal Gupta, Dhurjhoti Saha, Parashar Dhapola, Manish Sharma, Utsav Sen, Shigetaka Kitajima, Shantanu Chowdhury, Manjula Kalia, Sudhanshu Vrati
Stringent regulation of antiviral signaling and cellular autophagy is critical for the host response to virus infection. However, little is known how these cellular processes are regulated in the absence of type I interferon signaling. Here, we show that ATF3 is induced following Japanese encephalitis virus (JEV) infection, and regulates cellular antiviral and autophagy pathways in the absence of type I interferons in mouse neuronal cells. We have identified new targets of ATF3 and show that it binds to the promoter regions of Stat1, Irf9, Isg15 and Atg5 thereby inhibiting cellular antiviral signaling and autophagy...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821752/hybrid-nitric-oxide-donor-and-its-carrier-for-the-treatment-of-peripheral-arterial-diseases
#7
Duong Q Le, Aneetta E Kuriakose, Dat X Nguyen, Kytai T Nguyen, Suchismita Acharya
Nitric oxide (NO) has been known to promote physiological angiogenesis to treat peripheral arterial diseases (PAD) by increasing the vascular endothelial growth factor (VEGF) level in endothelial cells (ECs) and preventing platelet adherence and leukocyte chemotaxis. However, the ongoing ischemic event during peripheral ischemia produces superoxide and diminishes the NO bioavailability by forming toxic peroxynitrite anion. Here we disclose an efficacious hybrid molecule 4-(5-Amino-1,2,3-oxadiazol-3-yl)-2,2,6,6-tetramethyl-1-piperidinol (SA-2) containing both antioxidant and NO donor functionalities that provide a therapeutic level of NO necessary to promote angiogenesis and to protect ECs against hydrogen peroxide-induced oxidative stress...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821715/invasive-trophoblast-promote-stromal-fibroblast-decidualization-via-profilin-1-and-alox5
#8
E M Menkhorst, M L Van Sinderen, K Rainczuk, C Cuman, A Winship, E Dimitriadis
During the establishment of pregnancy, extravillous trophoblast (EVT) must invade into the uterine decidua to facilitate decidual artery remodelling to create the placental blood supply. The local decidual environment is thought to regulate trophoblast invasion, however these interactions are poorly defined in humans. Recent evidence in women suggests impaired decidualization is associated with miscarriage and preeclampsia. Primary human endometrial stromal cells (HESC) and first trimester extravillous trophoblast (EVTs) were used to assess the effect of EVT-secreted factors on HESC decidualization, adhesion, proliferation and migration...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821676/brief-novel-visual-experience-fundamentally-changes-synaptic-plasticity-in-the-mouse-visual-cortex
#9
Shuo Li, Laijian Wang, Xiaoxiu Tie, Kazuhiro Sohya, Xian Lin, Alfredo Kirkwood, Bin Jiang
Long-term potentiation (LTP) has been known to be a mechanism by which experience modifies synaptic responses in the neocortex. Visual deprivation in the form of dark exposure or dark rearing from birth enhances NMDAR-dependent LTP in layer 2/3 of visual cortex, a process often termed metaplasticity, which may involve changes in NMDAR subunit composition and function. However, the effects of re-exposure to light after dark rearing from birth on LTP induction have not been explored. Here, we showed that the light exposure after dark rearing revealed a novel NMDAR independent form of LTP in the layer 2/3 pyramidal cells in visual cortex of mice of both sexes which is dependent on mGluR5 activation and is associated with intracellular Ca2+ rise, CaMKII activity, PKC activity and intact protein synthesis...
August 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28821622/the-replication-and-transcription-activator-of-murine-gammaherpesvirus-68-cooperatively-enhances-cytokine-activated-stat3-mediated-gene-expression
#10
Hui-Chen Chang Foreman, Julie Armstrong, Alexis L Santana, Laurie T Krug, Nancy C Reich
Gammaherpesviruses (γΗVs) have a dynamic strategy for life-time persistence, involving productive infection, latency, and intermittent reactivation. In latency reservoirs, such as B lymphocytes, γΗV exists as a viral episome and expresses few viral genes. Although the ability of γHV to reactivate from latency and re-enter the lytic phase is challenging to investigate and control, it is known that the γΗV replication and transcription activator, RTA, can promote lytic reactivation. In this study, we provide first evidence that RTA of murine γΗV 68 (MHV68) selectively binds and enhances the activity of tyrosine-phosphorylated host STAT3...
August 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28821586/ku70-senses-htlv-1-dna-and-modulates-htlv-1-replication
#11
Jie Wang, Lixia Kang, Di Song, Lu Liu, Shuai Yang, Lingling Ma, Zhixiang Guo, Huaxia Ding, Hui Wang, Bo Yang
Human T lymphotropic virus type 1 (HTLV-1) belongs to the deltaretrovirus family and has been linked to multiple diseases. However, the innate host defense against HTLV-1 is unclear. In this study, we report that the expression of Ku70, a known DNA sensor against DNA viruses, could be induced by HTLV-1 infection in HeLa, PMA-differentiated THP1 cells, primary human monocytes, and human monocyte-derived macrophages. In these cells, the overexpression of Ku70 inhibited the HTLV-1 protein expression, whereas the knockdown of Ku70 promoted the HTLV-1 protein expression...
August 18, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28821549/phosphate-catalyzed-hydrogen-peroxide-formation-from-agar-gellan-and-%C3%AE%C2%BA-carrageenan-and-recovery-of-microorganisms-cultivability-by-catalase-and-pyruvate
#12
Kosei Kawasaki, Yoichi Kamagata
Previously, we reported that when agar is autoclaved with phosphate buffer, H2O2 is formed in the resulting medium (PT) and the colony count on the medium inoculated with environmental samples becomes much lower than that on a medium in which agar and phosphate are autoclaved separately (PS) (Appl Environ Microbiol 80:7659-7666). However, the physicochemical mechanisms underlying this observation remain largely unknown. Here, we determined the factors affecting H2O2 formation in agar. The H2O2 formation was pH-dependent: H2O2 was formed at high concentrations in alkaline or neutral phosphate buffer, but not in acidic one...
August 18, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28821439/effect-of-alcohol-on-skin-permeation-and-metabolism-of-an-ester-type-prodrug-in-yucatan-micropig-skin
#13
Makiko Fujii, Rieko Ohara, Azusa Matsumi, Kayoko Ohura, Naoya Koizumi, Teruko Imai, Yoshiteru Watanabe
We studied the effect that three alcohols, ethanol (EA), propanol (PA), and isopropanol (IPA), have on the skin permeation of p-hydroxy benzoic acid methyl ester (HBM), a model ester-type prodrug. HBM was applied to Yucatan micropig skin in a saturated phosphate buffered solution with or without 10% alcohol, and HBM and related materials in receptor fluid and skin were determined with HPLC. In the absence of alcohol, p-hydroxy benzoic acid (HBA), a metabolite of HBM, permeated the skin the most. The three alcohols enhanced the penetration of HBM at almost the same extent...
August 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28821433/abcb5-promotes-melanoma-metastasis-through-enhancing-nf-%C3%AE%C2%BAb-p65-protein-stability
#14
Shenghao Wang, Li Tang, Junyu Lin, Zhongliang Shen, Yikun Yao, Wei Wang, Shuai Tao, Chenjian Gu, Jie Ma, Youhua Xie, Yanfeng Liu
Melanoma is the most aggressive type of skin cancer. Melanoma has an extremely poor prognosis because of its high potential for vascular invasion, metastasis and recurrence. The mechanism of melanoma metastasis is not well understood. ATP-binding cassette sub-family B member 5 (ABCB5) plays a key role in melanoma growth. However, it is uncertain what function ABCB5 may exert in melanoma metastasis. In this report, we for the first time demonstrate ABCB5 as a crucial factor that promotes melanoma metastasis...
August 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28821209/cued-memory-reactivation-during-sws-abolishes-the-beneficial-effect-of-sleep-on-abstraction
#15
Nora Hennies, Matthew A Lambon Ralph, Simon J Durrant, James N Cousins, Penelope A Lewis
Study Objectives: Extracting regularities from stimuli in our environment and generalizing these to new situations are fundamental processes in human cognition. Sleep has been shown to enhance these processes, possibly by facilitating reactivation-triggered memory reorganization. Here, we assessed whether cued reactivation during slow wave sleep (SWS) promotes the beneficial effect of sleep on abstraction of statistical regularities. Methods: We used an auditory statistical learning task, in which the benefit of sleep has been firmly established...
August 1, 2017: Sleep
https://www.readbyqxmd.com/read/28821164/cape-gooseberry-physalis-peruviana-juice-as-a-modulator-agent-for-hepatocellular-carcinoma-linked-apoptosis-and-cell-cycle-arrest
#16
Hanaa A Hassan, Hanaa M Serag, Makwan S Qadir, Mohamed Fawzy Ramadan
BACKGROUND: Cape gooseberry (Physalis peruviana) fruit is highly nutritious with high content of health-promoting compounds including minerals, phenolic compounds, as well as vitamins A and C. Physalis peruviana fruits were used as mutagenic, antispasmodic, anticoagulant, and antileucemis agents. OBJECTIVE: The objective of the present work was to study the role of cape gooseberry juice (CG) as a natural modulator agent for adverse aspects associated with hepatocellular carcinoma (HCC)...
August 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28821138/biocompatible-chitin-carbon-nanotubes-composite-hydrogels-as-neuronal-growth-substrates
#17
Shuangquan Wu, Bo Duan, Ang Lu, Yanfeng Wang, Qifa Ye, Lina Zhang
In the past decades, extensive studies have demonstrated that carbon nanotubes (CNTs) could promote cell adhesion, proliferation and differentiation of neuronal cells. However, the potential cytotoxicity in biological systems severely restricted the utilization of CNTs as substrates for neural growth. In this study, biocompatible chitin/carbon nanotubes (Ch/CNT) composite hydrogels were developed via blending modified CNTs with chitin solution in 11wt% NaOH/4wt% urea aqueous system, and subsequently regenerating in ethanol...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821128/biomimetic-composite-scaffolds-based-on-surface-modification-of-polydopamine-on-electrospun-poly-lactic-acid-cellulose-nanofibrils
#18
Zhangqiang Yang, Junhui Si, Zhixiang Cui, Jianhua Ye, Xiaofeng Wang, Qianting Wang, Kaiping Peng, Wenzhe Chen, Shia-Chung Chen
An appropriate surface chemical property is crucial in tissue engineering scaffolds, which promotes cell attachment and proliferation. A biomimetic composite scaffold with a polydopamine (PDA) coating layer on electrospun poly(lactic acid) (PLA)/cellulose nanofibrils (CNF) composite nanofiber was developed in this study. PLA/CNF composite nanofibers were fabricated and then coated via treatment with a dopamine solution. The PDA coating layer was successfully formed on the surface of the PLA/CNF composite nanofiber by using a simple, environment-friendly, and effective procedure...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821054/enhanced-hydrolysis-of-bamboo-biomass-by-chitosan-based-solid-acid-catalyst-with-surfactant-addition-in-ionic-liquid
#19
Wenqing Si, Yichen Li, Jie Zheng, Shun'an Wei, Dan Wang
Surfactants were used for the hydrolysis of bamboo biomass to enhance lignocellulose hydrolysis. Tween 80, polyethylene glycol 4000 (PEG 4000), and sodium dodecyl sulfate (SDS) were tested as surfactants for improving the bamboo hydrolysis with a novel sulfonated cross-linked chitosan solid acid catalyst (SCCAC) in ionic liquid (IL). Compared to the use of only SCCAC in 1-Butyl-3-methylimidazolium chloride ([BMIM]Cl), the surfactants facilitated hydrolysis and improved the yield of total reducing sugar (TRS) under the same conditions...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821032/using-oxidized-amylose-as-carrier-of-linalool-for-the-development-of-antibacterial-wound-dressing
#20
Yongbo Lyu, He Ren, Mengchao Yu, Xinying Li, Defu Li, Changdao Mu
This study aimed to prepare antibacterial wound dressings based on collagen and linalool/oxidized amylose inclusion complex. Encapsulation with oxidized amylose was used as an effective way to introduce linalool into collagen matrix. Our results showed that the content of linalool in the composite dressings was efficiently increased thanks to the solubilization effect of oxidized amyloses. The developed composite dressings possessed porous structure. They had abilities to keep the wound in moist environment and meanwhile prevent the excess exudates accumulation...
October 15, 2017: Carbohydrate Polymers
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