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Ching-Yu Lee, Meng-Huang Wu, Chin-Chang Cheng, Tsung-Jen Huang, Tsung-Yu Huang, Chien-Yin Lee, Jou-Chen Huang, Yen-Yao Li
BACKGROUND: To the best of our knowledge, no study has compared gram-negative bacillary hematogenous pyogenic spondylodiscitis (GNB-HPS) with gram-positive coccal hematogenous pyogenic spondylodiscitis (GPC-HPS) regarding their clinical characteristics and outcomes. METHODS: From January 2003 to January 2013, 54 patients who underwent combined antibiotic and surgical therapy in the treatment of hematogenous pyogenic spondylodiscitis were included. RESULTS: Compared with 37 GPC-HPS patients, the 17 GNB-HPS patients were more often found to be older individuals, a history of cancer, and a previous history of symptomatic urinary tract infection...
December 6, 2016: BMC Infectious Diseases
Xia Song, Jing-Ling Zhu, Yuting Wen, Feng Zhao, Zhong-Xing Zhang, Jun Li
Chemotherapy is facing several limitations such as low water solubility of anticancer drugs and multidrug resistance (MDR) in cancer cells. To overcome these limitations, a thermoresponsive micellar drug delivery system formed by a non-covalently connected supramolecular block polymer was developed. The system is based on the host-guest interaction between a well-defined β-cyclodextrin (β-CD) based poly(N-isopropylacrylamide) star host polymer and an adamantyl-containing poly(ethylene glycol) (Ad-PEG) guest polymer...
November 16, 2016: Journal of Colloid and Interface Science
Xu Bai, Yun Liu
With the globalization of the world economy, international innovation collaboration has taken place all over the world. This study selects three emerging technologies (3D printing, big data and carbon nanotubes and graphene technology) among 20 countries as the research objects, using three patent-based indicators and network relationship analysis to reflect international collaboration patterns. Then we integrate empirical analyses to show effecting factors of international collaboration degrees by using panel data...
2016: PloS One
Chun Xiao, Qingping Wu, Jumei Zhang, Yizhen Xie, Wen Cai, Jianbin Tan
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Lin Zhi) has been used to treat diabetes in Chinese folk for centuries. Our laboratory previously demonstrated that Ganoderma lucidum polysaccharides (GLPs) had hypoglycemic effects in diabetic mice. Our aim was to identify the main bioactives in GLPs and corresponding mechanism of action. MATERIALS AND METHODS: Four polysaccharide-enriched fraction were isolated from GLPs and the antidiabetic activities were evaluated by type 2 diabetic mice...
November 27, 2016: Journal of Ethnopharmacology
Xiaowei Zhu, Chao Liu, Jianwei Duan, Xiaoyu Liang, Xuanling Li, Hongfan Sun, Deling Kong, Jing Yang
PURPOSE: Synthesis of star-shaped block copolymer with oxalyl chloride and preparation of micelles to assess the prospect for drug-carrier applications. MATERIALS AND METHODS: Three-arm star block copolymers of poly(lactic-co-glycolic acid) (3S-PLGA)-polyethylene glycol (PEG) were synthesized by ring-opening polymerization, then PEG as the hydrophilic block was linked to the terminal hydroxyl of 3S-PLGA with oxalyl chloride. Fourier-transform infrared (FT-IR) spectroscopy, gel-permeation chromatography (GPC), hydrogen nuclear magnetic resonance ((1)H-NMR) spectra, and differential scanning calorimetry were employed to identify the structure and properties of 3S-PLGA-PEG...
2016: International Journal of Nanomedicine
André M Striegel
No abstract text is available yet for this article.
August 2016: Chromatographia
Irina Sulaeva, Grigory Zinovyev, Jean-Michel Plankeele, Ivan Sumerskii, Thomas Rosenau, Antje Potthast
Technical lignins - waste products obtained from wood pulping or biorefinery processes - have so far required lengthy analysis procedures and different eluents for molar mass analysis by gel permeation chromatography (GPC). This challenge has become more pressing recently since attempts to utilize lignins have increased, leading to skyrocketing numbers of samples to be analyzed. A new approach, which uses the eluent DMSO/LiBr (0.5% w/v) and converts lignosulfonate salts into their acidic form before analysis, overcomes these limitations by enabling measurement of all kinds of lignins (kraft, organosolv, soda, lignosulfonates) in the same SEC system without the necessity of time-consuming derivatization steps before...
November 24, 2016: ChemSusChem
Li Zhu, Pan Wang, Ying-Jian Sun, Ming-Yuan Xu, Yi-Jun Wu
Tri-o-cresyl phosphate (TOCP) is a widely used organophosphorus compound, which can cause a neurodegenerative disorder, i.e., organophosphate-induced delayed neurotoxicity (OPIDN). The biochemical events in the initiation of OPIDN were not fully understood except for the essential inhibition of neuropathy target esterase (NTE). NTE, located in endoplasmic reticulum (ER), catalyzes the deacylation of phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) to glycerophosphocholine (GPC). The present study aims to study the changes of ER phospholipids profile as well as levels of important intermediates of phospholipid synthesis such as diacylglycerol (DAG) and phosphatidic acid (PA) at the initiation stage of OPIDN...
November 24, 2016: Scientific Reports
Xianzhi Meng, YUnqiao Pu, Chang Geun Yoo, Mi Li, Garima Bali, Doh-Yeon Park, Erica Gjersing, Mark Davis, Muchero Wellington, Gerald Tuskan, Timothy Tschaplinski, Arthur Jonas Ragauskas
In an effort to better understand and overcome biomass recalcitrance, six natural poplar variants were selected as the feedstock. Compositional analysis and physicochemical characterizations of these poplars were performed using different analytical techniques and the correlations between these physicochemical properties and enzymatic hydrolysis yield were investigated. Gel permeation chromatography (GPC) and 13C NMR were used to determine the degree of polymerization (DP) and crystallinity index (CrI) of cellulose, and the results along with the sugar release study indicated that cellulose DP likely played a more important role in enzymatic hydrolysis...
November 23, 2016: ChemSusChem
Yongle Wu, Hui Liu, Huiguo Ding
Glypican-3 (GPC3), a member of heparan sulfate proteoglycans, attaches to the cell membrane and is frequently observed to be elevated in hepatocellular carcinoma (HCC). However, GPC3 is not detected in normal liver tissues and benign liver lesions. Consequently, GPC3 is currently being used as a diagnostic biomarker and HCC-specific positron emission computed tomography probe to identify HCCs in normal liver tissues and benign liver lesions. The overexpression of GPC-3 in serum or liver tissue also predicts poor prognosis for HCC patients...
2016: Journal of Hepatocellular Carcinoma
Ciara McCabe, Vanessa Rocha-Rego
BACKGROUND: Dysfunctional neural responses to appetitive and aversive stimuli have been investigated as possible biomarkers for psychiatric disorders. However it is not clear to what degree these are separate processes across the brain or in fact overlapping systems. To help clarify this issue we used Gaussian process classifier (GPC) analysis to examine appetitive and aversive processing in the brain. METHOD: 25 healthy controls underwent functional MRI whilst seeing pictures and receiving tastes of pleasant and unpleasant food...
2016: PloS One
Hui Li, Haiyun Xu, Yinnan Zhang, Jitian Guan, Jie Zhang, Chongtao Xu, Zhiwei Shen, Bo Xiao, Chunlian Liang, Kaiyuan Chen, Jinling Zhang, Renhua Wu
OBJECTIVES: Bipolar disorder (BD) is a mental disorder characterized by periods of elevated mood and depression. Many individuals with BD are initially misdiagnosed and treated for unipolar depression (UD). In this study, we report direct comparisons between medication-free individuals with BD and those with UD in terms of the neurometabolites in the anterior cingulate cortex (ACC), medial prefrontal cortex (mPFC), parietal cortex (PC), and posterior cingulate cortex (PCC) of the brain...
November 2016: Bipolar Disorders
Wen-Chao Li, Xia Li, Lei Qin, Jia-Qing Zhu, Xiao Han, Bing-Zhi Li, Ying-Jin Yuan
In this study, the effect of ethylenediamine (EDA) on enzymatic hydrolysis with different cellulosic substrates and the approaches to reduce sugar loss in enzymatic hydrolysis were investigated. During enzymatic hydrolysis, xylose yield reduced 21.2%, 18.1% and 13.0% with 7.5mL/L EDA for AFEX pretreated corn stover (CS), washed EDA pretreated CS and CS cellulose. FTIR and GPC analysis demonstrated EDA reacted with sugar and produced high molecular weight (MW) compounds. EDA was prone to react with xylose other than glucose...
November 9, 2016: Bioresource Technology
Maryam Ijadi Bajestani, Seyyed Mohammad Mousavi, Arezou Jafari, Seyed Abbas Shojaosadati
Screening among some new isolated bacteria from oily samples, which were capable of producing extracellular polymeric substances (EPSs), one was selected and identified as Bacillus sonorensis. An efficient micro-total analysis approach was carried out to assay the produced EPSs by this bacterium. Sucrose and yeast concentrations as carbon and nitrogen sources, respectively, sodium salt concentration and initial pH were selected to be the variables in experimental design. Production of EPS in optimal condition was increased by 5...
November 15, 2016: International Journal of Biological Macromolecules
Changzhi Li, Haiwei Guo, Bo Zhang, Tao Dai, Zaojuan Qi, Aiqin Wang, Tao Zhang, Jianwei Ji
Lignins isolated from representative hardwood, softwood and grass materials, were effectively hydrocracked to aromatics catalyzed by W2C/AC. The effects of botanical species and fractionation methods on lignin structure and the activity of tungsten carbide were detailed studied. GPC, FT-IR, elemental analysis, 2D HSQC NMR showed that all the extracted samples shared the basic skeleton of lignin, whereas the fractionation method significantly affected the structure. Organosolv process provided lignin with structure more similar to the native lignin, which was liable to be depolymerized by W2C/AC catalyst...
November 10, 2016: ChemSusChem
Gerda Strifler, Eszter Tuboly, Anikó Görbe, Mihály Boros, Daniella Pécz, Petra Hartmann
BACKGROUND: We hypothesized that L-alpha-glycerylphosphorylcholine (GPC), a deacylatedphosphatidylcholine derivative, can influence the mitochondrial respiratory activity and in this way, may exert tissue protective effects. METHODS: Rat liver mitochondria were examined with high-resolution respirometry to analyze the effects of GPC on the electron transport chain in normoxic and anoxic conditions. Besides, Sprague-Dawley rats were subjected to sham operation or standardized liver ischemia-reperfusion (IR), with or without GPC administration...
2016: PloS One
Xianhai Zhao, Tingting Tong, HuiLing Li, Haojun Lu, Junli Ren, Aiping Zhang, Xiaomei Deng, Xiaoyang Chen, Ai-Min Wu
In this study, hemicelluloses were isolated from the apical, middle and basal segments of N. cadamba using a 2N KOH extraction procedure. Chemical composition and structural characterization of the three hemicellulosic fractions obtained were comparatively investigated by a combination of HPLC, GPC, FTIR, (1)H,(13)C, HSQC NMR and TGA techniques. According to the sugar analysis and spectral results, (4-O-methyl) glucuronoxylan was the primary hemicellulose identified in the samples with trace levels of mannan also present...
January 20, 2017: Carbohydrate Polymers
Georges Aoun, Ibrahim Nasseh, Sayde Sokhn
AIM: The aim of this study was to describe the morphology of the component, greater palatine canal-pterygopalatine fossa (GPC-PPF), in a Lebanese population using cone-beam computed tomography (CBCT) technology. MATERIALS AND METHODS: CBCT images of 79 Lebanese adult patients (38 females and 41 males) were included in this study, and a total of 158 cases were evaluated bilaterally. The length and path of the GPCs-PPFs were determined, and the data obtained analyzed statistically...
2016: Journal of Clinical Imaging Science
Jennifer Risso-Ballester, José M Cuevas, Rafael Sanjuán
Rates of spontaneous mutation determine the ability of viruses to evolve, infect new hosts, evade immunity and undergo drug resistance. Contrarily to RNA viruses, few mutation rate estimates have been obtained for DNA viruses, because their high replication fidelity implies that new mutations typically fall below the detection limits of Sanger and standard next-generation sequencing. Here, we have used a recently developed high-fidelity deep sequencing technique (Duplex Sequencing) to score spontaneous mutations in human adenovirus 5 under conditions of minimal selection...
November 2016: PLoS Pathogens
Wen-Ming Wan, Andrew W Baggett, Fei Cheng, Huina Lin, Shih-Yuan Liu, Frieder Jäkle
Free radical polymerization of B-vinyl- and B-styryl-functionalized azaborinine monomers gives well-defined hybrid polymers that were fully characterized by multinuclear NMR and GPC analysis; their solubility, thermal characteristics, and photophysical properties are dramatically different from those of the all-carbon polystyrene analogues.
November 4, 2016: Chemical Communications: Chem Comm
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