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https://www.readbyqxmd.com/read/28432433/glypican-3-mrna-expression-level-in-wilms-tumor-correlation-with-histological-type-stage-and-outcome
#1
Md Nahidul Wari, Archana George Vallonthaiel, Aijaz Ahmed, Deepali Saxena, Venkateswaran K Iyer, Sandeep R Mathur, Sandeep Agarwala, Sameer Bakhshi, V Srinivas, P Chattopadhyaya, Arundhati Sharma, S Datta Gupta, Amit Dinda
PURPOSE: To correlate expression of Glypican-3 in Wilms tumor with histopathology, stage, and outcome. METHODS: Glypican-3 mRNA expression by real-time PCR on tumor and normal germline samples from 75 fresh nephrectomies for Wilms tumor with fold change after normalization against GAPDH was compared. Survival analysis for event-free and overall survival (EFS, OS) with 2-year follow-up for Glypican-3 overexpression (>1.5 times) and clinicopathological parameters was performed...
April 21, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28431025/1h-magnetic-resonance-spectroscopy-of-live-human-sperm
#2
S Reynolds, S J Calvert, M N Paley, A A Pacey
STUDY QUESTION: Can 1H Magnetic Resonance Spectroscopy (MRS) be used to obtain information about the molecules and metabolites in live human spermatozoa? SUMMARY ANSWER: Percoll-based density gradient centrifugation (DGC) followed by a further two washing steps, yielded enough sperm with minimal contamination (<0.01%) from seminal fluid to permit effective MRS which detected significant differences (p < 0.05) in the choline/glycerophosphocholine, lipid and lactate regions of the 1H MRS spectrum between sperm in the pellet and those from the 40/80% interface...
April 18, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28426184/alterations-in-mandibular-morphology-associated-with-glypican-1-and-glypican-3-gene-mutations
#3
M Mian, S Ranjitkar, G C Townsend, P J Anderson
OBJECTIVES: Glypican 1 (GPC1) and glypican 3 (GPC3) are bone co-regulators that act downstream in many of the signalling pathways associated with craniosynostosis. Morphometric data from GPC-knockout mice were analysed to determine whether elimination of GPC1 and GPC3 genes would alter mandibular morphology. SETTING AND SAMPLE POPULATION: The murine model included five male and five female mandibles in each of GPC1-knockout, GPC1/GPC3-knockout and wild-type (control) groups...
April 20, 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28420236/human-hepatocarcinoma-cell-targeting-by-glypican-3-ligand-peptide-functionalized-silica-nanoparticles-implications-for-ultrasound-molecular-imaging
#4
Marco Di Paola, Alessandra Quarta, Francesco Conversano, Enzo Antonio Sbenaglia, Simona Bettini, Ludovico Valli, Giuseppe Gigli, Sergio Casciaro
Silica nanoparticles (SiNPs) are widely studied nanomaterials for their potential employment in advanced biomedical applications, such as selective molecular imaging and targeted drug delivery. SiNPs are generally low cost and highly biocompatible, can be easily functionalized with a wide variety of functional ligands, and have been demonstrated to be effective in enhancing ultrasound contrast at clinical diagnostic frequencies. Therefore, SiNPs might be used as contrast agents in echographic imaging. In this work, we have developed a SiNPs-based system for the in vitro molecular imaging of hepatocellular carcinoma cells that express high levels of glypican-3 protein (GPC-3) on their surface...
April 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28415547/effect-of-polymer-degradation-on-prolonged-release-of-paclitaxel-from-filomicelles-of-polylactide-poly-ethylene-glycol-block-copolymers
#5
Katarzyna Jelonek, Suming Li, Janusz Kasperczyk, Xiaohan Wu, Arkadiusz Orchel
Paclitaxel is one of the most efficient anticancer agents, but the conventional dosage formulations cause many side effects. PLA-PEG filomicelles are promising carriers of paclitaxel because high loading capacity and long term release can be achieved. Slow release of cytostatic drugs is very advantageous due to prolonged exposure of tumor cells to cytostatic over multiple cell cycles. The aim of this study was to evaluate the potential of bioresorbable PLA-PEG filomicelles for prolonged delivery of paclitaxel...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28413733/experimental-studies-on-the-hydrotreatment-of-kraft-lignin-to-aromatics-and-alkylphenolics-using-economically-viable-fe-based-catalysts
#6
Shilpa Agarwal, Ramesh Kumar Chowdari, Idoia Hita, Hero Jan Heeres
Limonite, a low-cost iron ore, was investigated as a potential hydrotreatment catalyst for kraft lignin without the use of an external solvent (batch reactor, initial H2 pressure of 100 bar, 4 h). The best results were obtained at 450 °C resulting in 34 wt % of liquefied kraft lignin (lignin oil) on lignin intake. The composition of the lignin oil was determined in detail (elemental composition, GC-MS, GC×GC-FID, and GPC). The total GC-detectable monomeric species amounts up to 31 wt % on lignin intake, indicating that 92 wt % of the products in the lignin oil are volatile and thus of low molecular weight...
March 6, 2017: ACS Sustainable Chemistry & Engineering
https://www.readbyqxmd.com/read/28412448/self-assembled-liposomes-of-dual-paclitaxel-phospholipid-prodrug-for-anticancer-therapy
#7
Longbing Ling, Yawei Du, Muhammad Ismail, Ruiyu He, Yongpeng Hou, Zhenglin Fu, Ying Zhang, Chen Yao, Xinsong Li
In this report, a newly liposomal formulation of paclitaxel (PTX) based on dual paclitaxel succinate glycerophosphorylcholine (Di-PTX-GPC) prodrug was developed. The Di-PTX-GPC prodrug was synthesised by conjugating PTX with GPC through esterification under N,N'-carbonyldiimidazole (CDI) and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) catalytic system. Di-PTX-GPC liposomes were prepared by thin film method and characterized by dynamic light scattering (DLS) and transmission electron microscope (TEM). The results indicated that the liposomes have an average diameter of 157...
April 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28411547/mechanical-properties-and-state-of-miscibility-in-poly-racd-l-lactide-co-glycolide-l-lactide-co-%C3%AE%C2%B5-caprolactone-blends
#8
S Petisco-Ferrero, A Etxeberria, J R Sarasua
Polymers based on lactic acid (PLA) are a very promising category of biopolymers. As they are multi-stimuli responsive, can, in many ways, positively interact with the host, stimulating the innate reparative machinery of the human body. Since biopolymers for medical applications are subject to restrictive regulations, blending stands out as an effective method for obtaining tailored properties within a reduced time to market if compared to synthesis. Hence, in this study a set of PDLGA/PLCL blends was obtained by means of thermoplastic techniques and then further characterized...
April 6, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28396277/duodenoscope-reprocessing-surveillance-with-adenosine-triphosphate-testing-and-terminal-cultures-a-clinical-pilot-study
#9
Kavel Visrodia, Yuri Hanada, Kelly M Pennington, Pritish K Tosh, Mark D Topazian, Bret T Petersen
BACKGROUND & AIMS: Recent reports of infectious outbreaks linked to duodenoscopes have led to proposals for duodenoscope surveillance culturing, which has inherent limitations. We aimed to assess the feasibility of real-time adenosine triphosphate (ATP) testing after manual cleaning, and its ability to predict reprocessing adequacy, as determined by terminal duodenoscope cultures. METHODS: Clinically used duodenoscopes underwent reprocessing per current guidelines...
April 7, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28388601/early-post-natal-exposure-to-intermittent-hypoxia-in-rodents-is-pro-inflammatory-impairs-white-matter-integrity-and-alters-brain-metabolism
#10
Robert A Darnall, Xi Chen, Krishnamurthy V Nemani, Chrystelle M Sirieix, Barjor Gimi, Susan Knoblach, Betty L McEntire, Carl E Hunt
BACKGROUND: Preterm infants are frequently exposed to intermittent hypoxia (IH) associated with apnea and periodic breathing that may result in inflammation and brain injury that later manifests as cognitive and executive function deficits. We used a rodent model to determine whether early postnatal exposure to IH would result in inflammation and brain injury. METHODS: Rat pups were exposed to IH from P2-P12. Control animals were exposed to room air. Cytokines were analyzed in plasma and brain tissue at P13 and P18...
April 7, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28388481/membrane-lipid-profiles-of-coral-responded-to-zinc-oxide-nanoparticle-induced-perturbations-on-the-cellular-membrane
#11
Chuan-Ho Tang, Ching-Yu Lin, Shu-Hui Lee, Wei-Hsien Wang
Zinc oxide nanoparticles (nZnOs) released from popular sunscreens used during marine recreation apparently endanger corals; however, the known biological effects are very limited. Membrane lipids constitute the basic structural element to create cell a dynamic structure according to the circumstance. Nano-specific effects have been shown to mechanically perturb the physical state of the lipid membrane, and the cells accommodating the actions of nZnOs can be involved in the alteration of the membrane lipid composition...
March 31, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28387717/relationships-among-different-water-soluble-choline-compounds-differ-between-human-preterm-and-donor-milk
#12
Sara Moukarzel, Lynda Soberanes, Roger A Dyer, Susan Albersheim, Rajavel Elango, Sheila M Innis
Choline is essential for infant development. Human milk choline is predominately present in three water-soluble choline (WSC) forms: free choline (FC), phosphocholine (PhosC), and glycerophosphocholine (GPC). It is unclear whether mother's own preterm milk and pooled donor milk differ in WSC composition and whether WSC compounds are interrelated. Mother's own preterm milk (n = 75) and donor milk (n = 30) samples from the neonatal intensive care unit, BC Women's Hospital were analyzed for WSC composition using liquid chromatography tandem mass spectrometry (LC-MS/MS)...
April 7, 2017: Nutrients
https://www.readbyqxmd.com/read/28378998/polyphosphoester-camptothecin-prodrug-with-reduction-response-prepared-via-michael-addition-polymerization-and-click-reaction
#13
Xueqiong Du, Yue Sun, Mingzu Zhang, Jinlin He, Peihong Ni
Polyphosphoesters (PPEs), as potential candidates for biocompatible and biodegradable polymers, play an important role in material science. Various synthetic methods have been employed in the preparation of PPEs such as polycondensation, polyaddition, ring-opening polymerization, and olefin metathesis polymerization. In this study, a series of linear PPEs has been prepared via one-step Michael addition polymerization. Subsequently, camptothecin (CPT) derivatives containing disulfide bonds and azido groups were linked onto the side chain of the PPE through Cu(I)-catalyzed azidealkyne cyclo-addition "click" chemistry to yield a reduction-responsive polymeric prodrug P(EAEP-PPA)-g-ss-CPT...
April 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28373660/synthesis-of-thermoplastic-xylan-lactide-copolymer-with-amidine-mediated-organocatalyst-in-ionic-liquid
#14
Xueqin Zhang, Huihui Wang, Chuanfu Liu, Aiping Zhang, Junli Ren
Ring-opening graft polymerization (ROGP) of L-Lactide (L-LA) is a practical method of altering the physical and chemical properties of lignocellulose. Previous studies have mainly investigated cellulose and tin-based catalysts, particularly of tin(II) 2-ethylhexanoate (Sn(oct)2), at high temperatures and reported low graft efficiencies. In the present study, ROGP of L-LA was successfully achieved on xylan-type hemicelluloses in ionic liquid (IL) 1-allyl-3-methylimidazolium chloride ([Amim]Cl) using 1,8-diazabicyclo[5...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28365430/old-antimicrobials-and-gram-positive-cocci-through-the-example-of-infective-endocarditis-and-bone-and-joint-infections
#15
Piseth Seng, Sophie Amrane, Matthieu Million, Andreas Stein
The management of some serious infections such as infective endocarditis (IE) and bone and joint infections (BJIs) caused by Gram-positive cocci (GPC) is complex and requires great responsiveness and effective antimicrobials with high bioavailability in heart valves or bone tissues. Treatment of these infections requires the use of a higher dosage that may result in increased toxicity or the use of new promising antimicrobials to control the infection. However, use of these new antimicrobials could still bring about new toxicity and resistance...
March 29, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28363656/structural-variations-of-lignin-macromolecule-from-different-growth-years-of-triploid-of-populus-tomentosa-carr
#16
Tian-Ying Chen, Bing Wang, Yu-Ying Wu, Jia-Long Wen, Chuan-Fu Liu, Tong-Qi Yuan, Run-Cang Sun
To better understand the variations of structural characteristics of lignin macromolecules during different growth years of Triploid of Populus tomentosa Carr, a novel lignin isolation procedure based on double ball-milling and enzymatic hydrolysis (DEL) was proposed in this study. The morphological distributions of lignin in the plant cell wall of these poplar wood samples were monitored by Confocal Raman Microscopy (CRM). The ultrahigh yields (105.1%-111.2%) of DELs were significantly higher than those (24...
March 29, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28362336/biodegradable-poly-amino-ester-with-aromatic-backbone-as-efficient-nonviral-gene-delivery-vectors
#17
Qiang Liu, Rong-Chuan Su, Wen-Jing Yi, Zhi-Gang Zhao
The development of gene delivery vectors with high efficiency and biocompatibility is one of the critical points of gene therapy. Two biodegradable poly(amino ester)s were synthesized via ring-opening polymerization between low molecular weight (LMW) PEI and diepoxide. The molecular weights of poly(amino ester)s were measured by GPC. Agarose gel retardation assays showed that these materials have good DNA-binding ability and can retard the electrophoretic mobility of plasmid DNA (pDNA) at a weight ratio of 1...
March 31, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28361144/borane-catalysed-postpolymerisation-modification-of-the-si-h-bonds-in-poly-phenylsilane
#18
P T K Lee, L Rosenberg
B(C6F5)3-catalysed hydrosilation, heterodehydrocoupling, and demethanative coupling reactions of the Si-H bonds in poly(phenylsilane) allow the introduction of 10-40% new sidechains in this polymer. The resulting new polymers contain an unusually wide variety of functionalities including Si-C, Si-O, Si-N, and Si-S bonds, whose presence is confirmed by NMR and IR spectroscopies. Gel permeation chromatography (GPC) and thermogravimetric analysis (TGA) are consistent with conservation of the all-silicon backbones in these modified polymers, a result of the high chemoselectivity of the borane-catalysed reactions for Si-H versus Si-Si bonds...
March 31, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28358885/exogenous-lactobacilli-mitigate-microbial-changes-associated-with-grain-fermentation-corn-oats-and-wheat-by-equine-fecal-microflora-ex-vivo
#19
Brittany E Harlow, Laurie M Lawrence, Patricia A Harris, Glen E Aiken, Michael D Flythe
Cereal grains are often included in equine diets. When starch intake exceeds foregut digestion starch will reach the hindgut, impacting microbial ecology. Probiotics (e.g., lactobacilli) are reported to mitigate GI dysbioses in other species. This study was conducted to determine the effect of exogenous lactobacilli on pH and the growth of amylolytic and lactate-utilizing bacteria. Feces were collected from 3 mature geldings fed grass hay with access to pasture. Fecal microbes were harvested by differential centrifugation, washed, and re-suspended in anaerobic media containing ground corn, wheat, or oats at 1...
2017: PloS One
https://www.readbyqxmd.com/read/28352173/lipid-coated-iron-oxide-nanoparticles-for-dual-modal-imaging-of-hepatocellular-carcinoma
#20
Jinying Liang, Xinxin Zhang, Yunqiu Miao, Juan Li, Yong Gan
The development of noninvasive imaging techniques for the accurate diagnosis of progressive hepatocellular carcinoma (HCC) is of great clinical significance and has always been desired. Herein, a hepatocellular carcinoma cell-targeting fluorescent magnetic nanoparticle (NP) was obtained by conjugating near-infrared fluorescence to the surface of Fe3O4 (NIRF-Fe3O4) NPs, followed by coating the lipids consisting of tumoral hepatocytes-targeting polymer (Gal-P123). This magnetic NP (GPC@NIRF-Fe3O4) with superparamagnetic behavior showed high stability and safety in physiological conditions...
2017: International Journal of Nanomedicine
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