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Andrea Maselli, Paolo Pani, Vitor Cardoso, Tiziano Abdelsalhin, Leonardo Gualtieri, Valeria Ferrari
Several quantum-gravity models of compact objects predict microscopic or even Planckian corrections at the horizon scale. We explore the possibility of measuring two model-independent, smoking-gun effects of these corrections in the gravitational waveform of a compact binary, namely, the absence of tidal heating and the presence of tidal deformability. For events detectable by the future space-based interferometer LISA, we show that the effect of tidal heating dominates and allows one to constrain putative corrections down to the Planck scale...
February 23, 2018: Physical Review Letters
Qian Zhou, Li Cui, Lamei Ren, Ping Wang, Chao Deng, Qiang Wang, Xuedong Fan
Chitooligosaccharide (COS) has the characteristic of antioxidant and antibacterial effects. To improve the properties of silk fibroin (SF), COS was enzymatically grafted onto SF membranes using a laccase from Trametes versicolor. d-Glucosamine hydrochloride (GAH) and p-hydroxyphenylacetamide (PHAD), as the model compound of COS and tyrosine residues in SF were utilized to disclose the grafting mechanism, respectively. The data from UPLC-TQD and GPC analysis implied that laccase might catalyze the oxidation of PHAD and led to the formation of self-polymerized products...
March 11, 2018: International Journal of Biological Macromolecules
Ewa Jaskiewicz, Thierry Peyrard, Radoslaw Kaczmarek, Agata Zerka, Marlena Jodlowska, Marcin Czerwinski
Antigens of the Gerbich blood group system are expressed on glycophorin C (GPC) and glycophorin D (GPD), minor sialoglycoproteins of human erythrocytes. GPC and GPD help maintain erythrocyte shape of and contributes to the stability of its membrane. There are six high-prevalence Gerbich antigens: Ge2, Ge3, Ge4, GEPL (GE10), GEAT (GE11), GETI (GE12) and five low-prevalence Gerbich antigens: Wb (GE5), Lsa (GE6), Ana (GE7), Dha (GE8), GEIS (GE9). Some Gerbich antigens (Ge4, Wb, Dha , GEAT) are expressed only on GPC, two (Ge2, Ana ) are expressed only on GPD, while others (Ge3, Lsa , GEIS, GEPL, GETI) are expressed on both GPC and GPD...
March 2, 2018: Transfusion Medicine Reviews
Minae Watanabe, Jun Ueyama, Eiji Ueno, Yuko Ueda, Masaya Oda, Yuko Umemura, Takashi Tanahashi, Yoshitomo Ikai, Isao Saito
Dinotefuran is an insecticide belonging to the neonicotinoid class, which is frequently used to control pests in paddy rice owing to its permeability and effectiveness against sucking insects. Since 2002, this insecticide has been commercially available in Japan, and has become controversial due to its high detection frequency in brown rice for primary consumption. In this study, the effects of processing and cooking on the reduction of dinotefuran residues in commercially available brown rice were investigated...
March 13, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Olga V Sizova, Alexander S Shashkov, Anna N Kondakova, Yuriy A Knirel, Rima Z Shaikhutdinova, Sergei A Ivanov, Angelina A Kislichkina, Lidia A Kadnikova, Aleksandr G Bogun, Svetlana V Dentovskaya
Lipopolysaccharide was isolated from bacteria Yersinia intermedia H9-36/83 (O:17) and degraded with mild acid to give an O-specific polysaccharide, which was isolated by GPC on Sephadex G-50 and studied by sugar analysis and 1D and 2D NMR spectroscopy. The polysaccharide was found to contain 3-deoxy-3-[(R)-3-hydroxybutanoylamino]-d-fucose (d-Fuc3NR3Hb) and the following structure of the heptasaccharide repeating unit was established: The structure established is consistent with the gene content of the O-antigen gene cluster...
February 28, 2018: Carbohydrate Research
Kerry R Belton, Yuan Tian, Limin Zhang, Mallappa Anitha, Philip B Smith, Gary H Perdew, Andrew D Patterson
The liver and the mammary gland have complementary metabolic roles during lactation. Substrates (e.g., glucose and amino acids) synthesized by the liver are released into the circulation and are taken up by the mammary gland for milk production (e.g., lactose and the glycerol backbone of milk triglycerides). The aryl hydrocarbon receptor (AHR) has been identified as a lactation regulator in mice, and its activation has been associated with myriad morphological, molecular, and functional defects such as stunted gland development, decreased milk production, and changes in gene expression...
March 9, 2018: Journal of Proteome Research
Chufen Yang, Zhaolin Xue, Yinglin Liu, Jiayu Xiao, Jingrui Chen, Lijuan Zhang, Jianwei Guo, Wenjing Lin
To improve the drug release rate in well-controlled manner, a new pH-sensitive triblock amphiphilic copolymer methyl poly(ethylene glycol) ether-b-poly(β-amino esters)-b-poly lactic acid (MPEG-b-PBAE-b-PLA) and its self-assembled micelles were developed for anticancer drug delivery. The average molecular weight and molecular structure of MPEG-b-PBAE-b-PLA were confirmed by gel permeation chromatography (GPC) and1 H NMR. The formation of self-assembled micelles, the microstructures at different pH values, and the distribution of doxorubicin (DOX) were investigated by dissipative particle dynamics (DPD) simulation combined with experimental techniques...
March 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Nabil Bensabeh, Joan Carlos Ronda, Marina Galia, Virginia Cadiz, Gerard Lligadas, Virgil Percec
Cu(0) wire-catalyzed single electron transfer-living radical polymerization (SET-LRP) of (-)-menthyl acrylate, a biobased hydrophobic monomer, was investigated at 25 ºC in ethanol, iso-propanol, ethyl lactate, 2,2,2-trifluoroethanol (TFE) and 2,2,3,3-tetrafluoropropanol (TFP). All solvents are known to promote, in the presence of N-ligands, the mechanistically required self-regulated disproportionation of Cu(I)Br into Cu(0) and Cu(II)Br2 . Both fluorinated alcohols brought out their characteristics of universal SET-LRP solvents and showed the proper polarity balance to mediate an efficient polymerization of this bulky and hydrophobic monomer...
March 7, 2018: Biomacromolecules
Yuichiro Uemura, Kairi Yamato, Ryo Sekiya, Takeharu Haino
Hydrogen bonding has been employed as a powerful tool for developing multi-component assemblies such as supramolecular polymers. We have prepared graphene quantum dot (GQD)-organic hybrid compounds (GQD-2b-e) by introducing 3,4,5-tri(hexadecyloxy)benzyl groups (C16) and linear chains terminated with a 2-ureido-4-[1H]-pyrimidione (UPy) moiety onto the periphery of GQD-1. GQD-2b-e formed supramolecular assemblies through hydrogen bonding between the UPy units. GPC analysis showed that GQDs with high loadings of the UPy group formed larger assemblies, and this trend was confirmed by DOSY and viscosity measurements...
March 5, 2018: Angewandte Chemie
Li Liu, Yan Wen, Lei Zhang, Peng Xu, Xiao Liang, Yanan Du, Ping Li, Awen He, QianRui Fan, Jingcan Hao, Wenyu Wang, Xiong Guo, Hui Shen, Qing Tian, Feng Zhang, Hong-Wen Deng
Context: Osteoporosis is a metabolic bone disease. The impact of blood metabolites on the development of osteoporosis remains elusive now. Objective: To explore the relationship between blood metabolites and osteoporosis. Design and Methods: We used 2,286 unrelated Caucasian subjects as discovery samples and 3,143 unrelated Caucasian subjects from the Framingham heart study (FHS) as replication samples. Bone mineral density (BMD) were measured using dual-energy X-ray absorptiometry...
March 1, 2018: Journal of Clinical Endocrinology and Metabolism
William Aguilar, Manuel Paz, Anayatzinc Vargas, Shu-Yuan Cheng, Cristina C Clement, Elise Champeil
Mitomycin C (MC), a potent antitumor drug, and decarbamoylmitomycin C (DMC), a derivative lacking the carbamoyl group, form highly cytotoxic DNA interstrand crosslinks. The major interstrand crosslink formed by DMC is the C1'' epimer of the major crosslink formed by MC. The molecular basis for the stereochemical configuration exhibited by DMC was investigated using biomimetic synthesis. The formation of DNA-DNA crosslinks by DMC is diastereospecific and diastereodivergent: Only the 1''S- diastereomer of the initially formed monoadduct can form crosslinks at GpC sequences, and only the 1''R- diastereomer of the monoadduct can form crosslinks at CpG sequences...
March 5, 2018: Chemistry: a European Journal
Binglin Li, Xin Lu, Jia Wang, Xiaodong He, Quliang Gu, Lijing Wang, Yongxia Yang
Atherosclerosis (AS) is a multi-factorial chronic disease commonly associated with the mechanisms of metabolism disorder, endothelial dysfunction and chronic inflammation. AS an inflammatory molecule, p-selectin glycoprotein ligand-1 (PSGL-1) played an important role in the inflammatory process of atherogenesis involving the recruitment of leukocyte and transmitting signals to activate leukocyte during the adhesion process. So far, there has been little study regarding the effects of PSGL-1 on AS progression and the metabolic regulation...
2018: International Journal of Biological Sciences
Mohd Faizan Siddiqui, Bilqees Bano
Carbendazim is a broad spectrum benzimidazole fungicide which is used to ensure plants' protection from pest and pathogens' invasion. The present work describes the impact of carbendazim (CAR) on garlic phytocystatin (GPC) which is a crucial plant regulatory protein. Interaction of carbendazim with GPC has been investigated through various biophysical techniques viz. UV absorption, fluorescence spectroscopy, isothermal titration calorimetry, far-UV circular dichroism and FTIR spectroscopy which showed binding between them with consequent modulatory effects...
February 2018: Pesticide Biochemistry and Physiology
Asmaa M Zaazaa, Maha S Lokman, Aziza B Shalby, Hanaa H Ahmed, Sayed A El-Toumy
This research work was initiated to explore the efficacy of ellagic acid in mitigation of hepatocarcinogenesis in rats. Rats were distributed into 4 groups; negative control, hepatocellular carcinoma (HCC), doxorubicin and ellagic acid. Serum alpha-fetoprotein (AFP), glypican-3 (GPC-3), signal transducer and activator of transcription 3 (STAT3) and suppressors of cytokine signaling 3 (SOCS3) levels were assayed by ELISA. Immunohistochemical examination of hepatic VEGF expression was also conducted, along with histological procedures for examination of liver tissue sections...
February 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Stephen J Clark, Ricard Argelaguet, Chantriolnt-Andreas Kapourani, Thomas M Stubbs, Heather J Lee, Celia Alda-Catalinas, Felix Krueger, Guido Sanguinetti, Gavin Kelsey, John C Marioni, Oliver Stegle, Wolf Reik
Parallel single-cell sequencing protocols represent powerful methods for investigating regulatory relationships, including epigenome-transcriptome interactions. Here, we report a single-cell method for parallel chromatin accessibility, DNA methylation and transcriptome profiling. scNMT-seq (single-cell nucleosome, methylation and transcription sequencing) uses a GpC methyltransferase to label open chromatin followed by bisulfite and RNA sequencing. We validate scNMT-seq by applying it to differentiating mouse embryonic stem cells, finding links between all three molecular layers and revealing dynamic coupling between epigenomic layers during differentiation...
February 22, 2018: Nature Communications
Antoinette Burger, Samantha J Brooks, Dan J Stein, Fleur M Howells
BACKGROUND: Abuse of methamphetamine (MA) is a global health concern. Previous1 H-MRS studies have found that, with methamphetamine abstinence (MAA), there are changes in n-acetyl-aspartate (NAA/Cr), myo-inositol (mI/Cr), choline (Cho/Cr and Cho/NAA), and glutamate with glutamine (Glx) metabolites. Limited studies have investigated the effect of acute MAA, and acute-to-short-term MAA on brain metabolites. METHODS: Adults with chronic MA dependence (n = 31) and healthy controls (n = 22) were recruited...
February 19, 2018: Drug and Alcohol Dependence
Cordula Braun, Helen H Handoll
BACKGROUND: Knowledge about Minimal Important Differences (MIDs) is essential for the interpretation of continuous outcomes, especially patient-reported outcome measures (PROMS). OBJECTIVE: The aim of this study was to estimate the MID for the Western Ontario Rotator Cuff Index (WORC: score 0 (best) to 2100 (worst disability)) in adults with shoulder pain associated with partial-thickness rotator cuff tears, 'symptomatic PTTs', undergoing conservative treatment with physiotherapy...
February 12, 2018: Musculoskeletal Science & Practice
Nuttawut Thuaksuban, Rungrot Pannak, Pleumjit Boonyaphiphat, Naruporn Monmaturapoj
BACKGROUND: Biocompatibility and degradation of poly ε-caprolactone (PCL)-Biphasic Calcium Phosphate (BCP) scaffolds fabricated by the "Melt Stretching and Compression Molding (MSCM)" technique were evaluated in rat models. OBJECTIVES: Degradation behaviors and histological biocompatibility of the PCL-20% BCP MSCM scaffolds and compare with those of PCL-20% β-tricalcium phosphate (TCP) scaffolds commercially fabricated by Fused Deposition Modeling (FDM) were evaluated...
2018: Bio-medical Materials and Engineering
Mitra Alami-Milani, Parvin Zakeri-Milani, Hadi Valizadeh, Roya Salehi, Mitra Jelvehgari
Objectives: Micelles have been studied as nanoparticulate drug delivery systems for improving the topical ocular delivery of hydrophobic drugs. The objective of this study was to develop and characterize dexamethasone-loaded polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) micelles to improve patient compliance and enhance the ocular bioavailability of poorly water-soluble drugs. Materials and Methods: The PCL-PEG-PCL copolymers were synthesized via the ring opening polymerization of ε-caprolactone in the presence of PEG...
February 2018: Iranian Journal of Basic Medical Sciences
Rong Tang, Jie Hao, Ruijie Zong, Fangxia Wu, Yangyang Zeng, Zhenqing Zhang
In this study, the TEMPO-mediated (TEMPO/NaBr/NaClO) oxidation pattern of curdlan was investigated through comprehensively structural analysis of the corresponding oxidized products. During the structural analysis, infrared spectroscopy (IR), nuclear magnetic resonance (NMR) spectroscopy, gel permeation chromatography tandem multiple angle laser scattering (GPC-MALS) and ultra-high performance liquid chromatography tandem quadrupole time of flight mass spectrometry (UHPLC-Q/TOF-MS) were applied. As a result, the homogenous β1-3 polyglucuronic acids (MW, 49...
April 15, 2018: Carbohydrate Polymers
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