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https://www.readbyqxmd.com/read/29147656/polysaccharides-from-trichosanthes-fructus-via-ultrasound-assisted-enzymatic-extraction-using-response-surface-methodology
#1
Fujia Chen, Dahong Li, Hongqi Shen, Chunhong Wang, Enzhong Li, Huihui Xing, Li Guo, Qingchun Zhao, Junhao Shi, Hoang Nguyen, Jiayang Liu
An efficient procedure for ultrasound-assisted enzymatic extraction of crude polysaccharides from Trichosanthes Fructus (crude TFP) using response surface methodology (RSM) was developed. The Box-Behnken design was applied to optimize the effects of pH (X1), enzyme amount (X2), extraction temperature (X3), and liquid-to-solid ratio (X4) on the extraction. The statistical analysis indicated that the independent variables (X4, X2, and X3), the quadratic coefficients (X1(2), X2(2), X3(2), and X4(2)), and the interaction coefficient (X1X3) had significant impact on the yield of crude TFP...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29143029/triphenylsulfonium-topophotochemistry
#2
E Despagnet-Ayoub, W W Kramer, W Sattler, A Sattler, P J LaBeaume, J W Thackeray, J F Cameron, T Cardolaccia, A A Rachford, J R Winkler, H B Gray
The products from the 193 nm irradiation of triphenylsulfonium nonaflate (TPS) embedded in a poly(methyl methacrylate) (PMMA) film have been characterized. The analysis of the photoproduct formation was performed using chromatographic techniques including HPLC, GPC and GC-MS as well as UV-vis and NMR spectroscopic methods. Two previously unreported TPS photoproducts, triphenylene and dibenzothiophene, were detected; additionally, GPC and DOSY-NMR spectroscopic analyses after irradiation suggested that TPS fragments had been incorporated into the polymer film...
November 16, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29135095/does-upfront-therapy-with-cytoreductive-surgery-and-hipec-confer-a-survival-benefit-in-patients-with-synchronous-gastric-peritoneal-carcinomatosis-when-compared-with-patients-with-metachronous-gastric-peritoneal-carcinomatosis
#3
Nikolaos Kopanakis, Elias Efstathiou, Dimitrios Sarris, John Spiliotis
Gastric cancer (GC) remains the second leading cause of cancer death worldwide, accounting for 8% of the total cases and 10% of total deaths in 2008. Surgery remains the curative treatment option for GC and the main reason for treatment failure is peritoneal recurrence which, according to the literature, occurs in 40-60% of the cases, despite extensive surgery including D2 lymph node dissection. The hyperthermic intraperitoneal chemotherapy (HIPEC) technique is increasingly used in the treatment of primary and digestive peritoneal carcinomatosis (PC), in association with cytoreductive surgery (CRS)...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29133981/electrostatic-interactions-between-polyglutamic-acid-and-polylysine-yields-stable-polyion-complex-micelles-for-deoxypodophyllotoxin-delivery
#4
Yutong Wang, Liping Huang, Yan Shen, Lidan Tang, Runing Sun, Di Shi, Thomas J Webster, Jiasheng Tu, Chunmeng Sun
To achieve enhanced physical stability of poly(ethylene glycol)-poly(d,l-lactide) polymeric micelles (PEG-PDLLA PMs), a mixture of methoxy PEG-PDLLA-polyglutamate (mPEG-PDLLA-PLG) and mPEG-PDLLA-poly(l-lysine) (mPEG-PDLLA-PLL) copolymers was applied to self-assembled stable micelles with polyion-stabilized cores. Prior to micelle preparation, the synthetic copolymers were characterized by (1)H-nuclear magnetic resonance (NMR) and infrared spectroscopy (IR), and their molecular weights were calculated by (1)H-NMR and gel permeation chromatography (GPC)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29129788/a-new-formulation-of-poly-maotib-nanoparticles-as-an-efficient-contrast-agent-for-in-vivo-x-ray-imaging
#5
Justine Wallyn, Nicolas Anton, Christophe Serra, Michel Bouquey, Mayeul Collot, Halina Anton, Jean-Luc Weickert, Nadia Messaddeq, Thierry F Vandamme
Polymeric nanoparticles (PNPs) are gaining increasing importance as nanocarriers or contrasting material for preclinical diagnosis by micro-CT scanner. Here, we investigated a straightforward approach to produce a biocompatible, radiopaque, and stable polymer-based nanoparticle contrast agent, which was evaluated on mice. To this end, we used a nanoprecipitation dropping technique to obtain PEGylated PNPs from a preformed iodinated homopolymer, poly(MAOTIB), synthesized by radical polymerization of 2-methacryloyloxyethyl(2,3,5-triiodobenzoate) monomer (MAOTIB)...
November 9, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29128591/hemicellulose-isolated-from-waste-liquor-of-viscose-fiber-mill-for-preparation-of-polyacrylamide-hemicellulose-hybrid-films
#6
Jian Du, Chao Li, Yadong Zhao, Haisong Wang
Huge amount of waste hemicellulose liquor annually produced in China was burned or discharged into surrounding environment without further sufficient utilization, causing severely environmental issues. In order to solve this problem, this study aimed to find a way to effectively use aqueous waste hemicellulose solution from viscose fiber mills for bio-based materials development. Hereby, Polyacrylamide-Hemicellulose hybrid films were synthesized through the copolymerization of acrylamide (AM) monomers and hemicellulose initiated by potassium persulfate/N,N,N',N'-tetramethylethylenediamine (KPS/TMEDA) redox initiator system with cross-linker N,N-Methylene-bis(acrylamide) (MBA)...
November 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29128519/genetic-structure-of-two-erythrocyte-binding-antigens-of-plasmodium-falciparum-reveals-a-contrasting-pattern-of-selection
#7
Pramita Chowdhury, Srikanta Sen, Sumana Datta Kanjilal, Sanghamitra Sengupta
Erythrocyte binding antigens 175 (EBA-175) and 140 (EBA-140) play key roles in erythrocyte invasion by binding to glycophorin A (GPA) and C (GPC) respectively in human malaria. Since antigenic variation in malaria endemic region is a major barrier to development of effective vaccine, we explore the nature and pattern of sequence diversity of these two vaccine candidates in Kolkata, India. Population genetic parameters based on parasite sequences representing region II of Pfeba-175 and Pfeba-140 genes were estimated using DnaSP V...
November 8, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29122225/-web-visit-patterns-for-the-clinical-practice-guidelines-for-management-of-depressive-disorder-and-alcohol-abuse-dependence
#8
Fernando Suárez-Obando, Carlos Gómez Restrepo
INTRODUCTION: Clinical practice guidelines (CPG) are a set of recommendations for professionals, patients, and families, in order to make decisions about health care. The CPG respond to the need for concise, accurate, practical, and up to date information. In the field of mental health, Colombia has developed three GPC; alcohol (GPC-OH), depression (GPC-TDA), and schizophrenia. OBJECTIVES: To describe the Web Portal traffic related to psychiatry guidelines, with emphasis on the number of visits, distribution throughout Colombian cities, and estimating user behaviour patterns...
October 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/29118993/cellular-characteristics-of-keratin-19-positive-canine-hepatocellular-tumours-explain-its-aggressive-behaviour
#9
Renee G van Sprundel, Ted Sgam van den Ingh, Baukje A Schotanus, Monique E van Wolferen, Louis C Penning, Jan Rothuizen, Bart Spee
The expression of the hepatic progenitor cell marker keratin 19 (K19) in canine hepatocellular carcinomas is linked with a poor prognosis. To better understand this aggressive behaviour, K19-positive hepatocellular carcinomas (n=5) and K19-negative hepatocellular adenomas (n=6) were immunohistochemically stained for proteins involved in malignant tumour development. The K19-positive carcinomas showed marked positivity for platelet-derived growth factor receptor alpha polypeptide (PDGFRα), laminin, integrin beta-1/CD29, B-cell-specific Moloney murine leukaemia virus Integration site 1, glypican-3 (GPC-3) and prominin-1/CD133, in contrast with K19-negative hepatocellular adenomas...
2017: Veterinary Record Open
https://www.readbyqxmd.com/read/29117096/a-generalized-polynomial-chaos-based-approach-to-analyze-the-impacts-of-process-deviations-on-mems-beams
#10
Lili Gao, Zai-Fa Zhou, Qing-An Huang
A microstructure beam is one of the fundamental elements in MEMS devices like cantilever sensors, RF/optical switches, varactors, resonators, etc. It is still difficult to precisely predict the performance of MEMS beams with the current available simulators due to the inevitable process deviations. Feasible numerical methods are required and can be used to improve the yield and profits of the MEMS devices. In this work, process deviations are considered to be stochastic variables, and a newly-developed numerical method, i...
November 8, 2017: Sensors
https://www.readbyqxmd.com/read/29115972/plasmodium-reichenowi-eba-140-merozoite-ligand-binds-to-glycophorin-d-on-chimpanzee-red-blood-cells-shedding-new-light-on-origins-of-plasmodium-falciparum
#11
Agata Zerka, Radoslaw Kaczmarek, Marcin Czerwinski, Ewa Jaskiewicz
BACKGROUND: All symptoms of malaria are caused by the intraerythrocytic proliferation of Plasmodium merozoites. Merozoites invade erythrocytes using multiple binding ligands that recognise specific surface receptors. It has been suggested that adaptation of Plasmodium parasites to infect specific hosts is driven by changes in genes encoding Plasmodium erythrocyte-binding ligands (EBL) and reticulocyte-binding ligands (RBL). Homologs of both EBL and RBL, including the EBA-140 merozoite ligand, have been identified in P...
November 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29115187/hyaluronate-parathyroid-hormone-peptide-conjugate-for-transdermal-treatment-of-osteoporosis
#12
Minsoo Cho, Seulgi Han, Hyemin Kim, Ki Su Kim, Sei Kwang Hahn
Human parathyroid hormone 1-34 fragment (PTH1-34) has been used as a FDA-approved therapeutics to treat osteoporosis by daily subcutaneous injection. In this work, we successfully developed PTH1-34 conjugated hyaluronic acid (HA) for the transdermal treatment of osteoporosis with improved patient compliance. HA-PTH1-34 conjugate was synthesized by the coupling reaction between aldehyde group introduced to HA and amine group of PTH1-34. After characterization by gel permeation chromatography (GPC) and ELISA, the biological effect of HA-PTH1-34 conjugate on the proliferation of human osteoblast cells was confirmed by in vitro calcium colorimetric assay and cAMP assay...
November 8, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29113895/isolation-structural-characterization-and-antiproliferative-activity-of-phycocolloids-from-the-red-seaweed-laurencia-papillosa-on-mcf-7-human-breast-cancer-cells
#13
Ahmed Ghannam, Hossam Murad, Marie Jazzara, Adnan Odeh, Abdul Wahab Allaf
Hydrocolloids from seaweeds (phycocolloids) have interesting functional properties like antiproliferative activity. Marine algae consumptions are linked to law cancer incidences in countries that traditionally consume marine products. In this study, we have investigated water-soluble sulfated polysaccharides isolated from the red seaweed Laurencia papillosa and determined their chemical characteristics and biological activities on the human breast cancer cell line MCF-7. Total polysaccharides were extracted and fractionated from L...
November 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29112901/novel-method-for-the-determination-of-average-molecular-weight-of-natural-polymers-based-on-2d-dosy-nmr-and-chemometrics-example-of-heparin
#14
Yulia B Monakhova, Bernd W K Diehl, Tung X Do, Margit Schulze, Steffen Witzleben
Apart from the characterization of impurities, the full characterization of heparin and low molecular weight heparin (LMWH) also requires the determination of average molecular weight, which is closely related to the pharmaceutical properties of anticoagulant drugs. To determine average molecular weight of these animal-derived polymer products, partial least squares regression (PLS) was utilized for modelling of diffused-ordered spectroscopy NMR data (DOSY) of a representative set of heparin (n=32) and LMWH (n=30) samples...
November 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29111268/selective-aminolysis-of-acetylated-lignin-toward-simultaneously-improving-thermal-oxidative-stability-and-maintaining-mechanical-properties-of-polypropylene
#15
Dezhan Ye, Jinfeng Kong, Shaojin Gu, Yingshan Zhou, Caoxing Huang, Weilin Xu, Xi Zhang
Even with outstanding radical capturing ability, the utilization of lignin as a natural antioxidant in polypropylene (PP) still has been pended. Usually, the compatibility of its blends is improved based on the reaction of hydroxyl content, thus leading to the decreasing content of phenolic hydroxyl (Ph-OH) group and inferior thermal-oxidative stability of lignin blends. Here, the selective aminolysis of acetylated Kraft lignin (pyr-KL) was investigated, which structures were characterized using FTIR, (31)P-NMR and GPC...
October 27, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29106054/a-new-pentiptycene-based-dianhydride-and-its-high-free-volume-polymer-for-co2-removal
#16
Ahmad Arabi Shamsabadi, Farzad Seidi, Mohammad Nozari, Masoud Soroush
In addition to possessing excellent chemical, mechanical and thermal stability, polyimides and polyetherimides have excellent solubility in many solvents, rendering them suitable for membrane preparation. In this paper, we report the synthesis and characterization of two new monomers [a pentiptycene-based dianhydride (PPDAn) and a pentiptycene imide-containing diamine (PPImDA)], and a pentiptycene-based polyimide [PPImDA-4, 4'-hexafluoroisopropylidene diphthalic anhydride (PPImDA-6FDA)]. The products are characterized using FTIR, 1H NMR, GPC, mass spectroscopy, XPS, TGA, DSC, BET, and XRD...
November 6, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29104195/-injection-of-high-concentration-glucose-solution-for-pleural-coating-reduces-postoperative-recurrence-of-spontaneous-pneumothorax-a-short-term-retrospective-study
#17
Kenji Tsuboshima, Teppei Wakahara, Yasumi Matoba, Hidenori Yamana, Hiroaki Oue, Yoshihisa Watanabe, Toru Ono
BACKGROUND: Video-assisted thoracoscopic surgery (VATS) is the standard treatment for patients with spontaneous pneumothorax (SP). However, postoperative recurrence is not infrequent even with an absorbable covering sheet used to reinforce the visceral pleura. Recent reports suggest that intraoperative injection of a highly concentrated glucose solution into the thoracic cavity provides effective prophylaxis against postoperative SP recurrence. Since September 2015, we have been injecting 50 ml of 50 % glucose solution intraoperatively for pleural coating (GPC) around an absorbable sheet to prevent postoperative SP recurrence...
November 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29101867/synthesis-dna-binding-and-cytotoxic-activity-of-pyrimido-4-5-4-5-thieno-2-3-b-quinoline-with-9-hydroxy-4-3-diethylaminopropylamino-and-8-methoxy-4-3-diethylaminopropylamino-substitutions
#18
Hulihalli N KiranKumar, Heggodu G RohitKumar, Gopal M Advirao
Two new derivatives of pyrimido[4',5';4,5]thieno(2,3-b)quinoline (PTQ), 9-hydroxy-4-(3-diethylaminopropylamino)pyrimido[4',5';4,5]thieno(2,3-b)quinoline (Hydroxy-DPTQ) and 8-methoxy-4-(3-diethylaminopropylamino)pyrimido[4',5';4,5]thieno(2,3-b)quinoline (Methoxy-DPTQ) were synthesized and their DNA binding ability was analyzed using spectroscopy (UV-visible, fluorescence and circular dichroism), ethidium bromide dye displacement assay, melting temperature (Tm) analysis and computational docking studies. The hypochromism in UV-visible spectrum and increased fluorescence emission of Hydroxy-DPTQ and Methoxy-DPTQ in the presence of DNA suggested the molecule-DNA interaction...
November 1, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29099241/in-vitro-and-in-vivo-delivery-of-gliclazide-loaded-mpeg-pcl-micelles-and-its-kinetic-release-and-solubility-study
#19
Hossein Danafar, Hoda Jaberizadeh, Sina Andalib
In this study, drug delivery system of gliclazide, a poorly soluble drug, was developed and evaluated in vitro and in vivo. We synthesized five series of mPEG-PCL di block copolymers. The structure of the copolymers was characterized by (1)H-NMR, Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and gel permeation chromatography (GPC) techniques. In this study, gliclazide was encapsulated within micelles through a single-step nano-precipitation method, leading to formation of gliclazide/mPEG-PCL micelles...
November 3, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29071179/novel-hyaluronic-acid-conjugates-for-dual-nuclear-imaging-and-therapy-in-cd44-expressing-tumors-in-mice-in-vivo
#20
Ravindra Dhar Dubey, Rebecca Klippstein, Julie Tzu-Wen Wang, Naomi Hodgins, Kuo-Ching Mei, Jane Sosabowski, Robert C Hider, Vincenzo Abbate, Prem N Gupta, Khuloud T Al-Jamal
Hyaluronic acid, a natural CD44 receptor ligand, has attracted attention in the past years as a macromolecular delivery of anticancer agents to cancer. At the same time, the clinical applications of Gemcitabine (Gem) have been hindered by its short biological half-life, high dose and development of drug resistance. This work reports the synthesis of a hyaluronic acid (HA) conjugate for nuclear imaging, and in vivo Gem delivery to CD44-expressing solid tumors in mice. HA was individually conjugated, via amide coupling, to Gem (HA-Gem), 4'-(aminomethyl)fluorescein hydrochloride (HA-4'-AMF) or tris(hydroxypyridinone) amine (HA-THP) for cancer therapy, in vitro tracking or single photon emission computed tomography/computed tomography (SPECT/CT) imaging, respectively...
2017: Nanotheranostics
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