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Mauro Montalbano, Jeremias Georgiadis, Ashlyn L Masterson, Joshua T McGuire, Janika Prajapati, Ali Shirafkan, Cristiana Rastellini, Luca Cicalese
Glypican-3 (GPC-3), a transmembrane heparan sulfate proteoglycan (HSPG), has recently been investigated as a player in tissue-dependent cellular signaling, specifically as a regulator of growth. Noteworthy, the regulatory protein has been implicated in both stimulatory and inhibitory pathways involving cell growth. Initially, GPC-3 was thought to act as a cell cycle regulator, as a loss-of-function mutation in the gene caused a hyper-proliferative state known as Simpson-Golabi-Behmel (SGB) overgrowth syndrome...
January 18, 2017: Oncology Reports
Berend Terluin, Iris Eekhout, Caroline B Terwee
OBJECTIVES: Patients have their individual minimal important changes (iMICs) as their personal benchmarks to determine whether a perceived health-related quality of life (HRQOL) change constitutes a (minimally) important change for them. We denote the mean iMIC in a group of patients as the "genuine MIC" (gMIC). The aims of this paper are (1) to examine the relationship between the gMIC and the anchor-based minimal important change (MIC), determined by receiver operating characteristics (ROC) analysis or by predictive modeling; (2) to examine the impact of the proportion of improved patients on these MICs; and (3) to explore the possibility to adjust the MIC for the influence of the proportion of improved patients...
January 13, 2017: Journal of Clinical Epidemiology
Ruiyu He, Yawei Du, Longbing Ling, Muhammad Ismail, Yongpeng Hou, Chen Yao, Xinsong Li
Bexarotene (Bex), a synthetic retinoid X receptor-selective activator, has been proved to be an efficacious chemotherapeutic agent. But, its clinical application is limited due to the poor solubility. In this report, dual bexarotene-tailed phospholipid (DBTP) conjugate based nanovesicles were prepared in order to develop new nanoformulation. DBTP conjugate was first synthesized by conjugating two Bex molecules with glycerophosphorylcholine (GPC) through facial esterification. The amphiphilic DBTP nanovesicles were prepared without any additive by reverse-phase evaporation method...
January 11, 2017: European Journal of Pharmaceutical Sciences
Pietro Pepe, Sebastiano Cimino, Antonio Garufi, Giandomenico Priolo, Giorgio Ivan Russo, Raimondo Giardina, Giulio Reale, Michele Barbera, Paolo Panella, Michele Pennisi, Giuseppe Morgia
INTRODUCTION: The detection rate for significant prostate cancer of extended vs saturation vs mMRI/TRUS fusion biopsy was prospectively evaluated in men enrolled in active surveillance (AS) protocol. Mterials and methods: From May 2013 to September 2016 75 men aged 66 years (median) with very low risk PCa were enrolled in an AS protocol and elegible criteria were: life expectancy greater than 10 years, cT1C, PSA below 10 ng/ml, PSA density < 0.20, 2 < unilateral positive biopsy cores, Gleason score (GS) equal to 6, greatest percentage of cancer (GPC) in a core < 50%...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
Brittany E Harlow, Michael D Flythe, Glen E Aiken
AIMS: The objective was to determine the effect of biochanin A (BCA), an isoflavone produced by red clover (Trifolium pratense L.), on corn fermentation by rumen microorganisms. METHODS AND RESULTS: When bovine rumen bacterial cell suspensions (n = 3) were incubated (24 h, 39 °C) with ground corn, amylolytic bacteria including group D Gram-positive cocci (GPC; Streptococcus bovis; enterococci) proliferated, cellulolytic bacteria were inhibited, lactate accumulated, and pH declined...
January 5, 2017: Journal of Applied Microbiology
Birk Thiedemann, Philipp J Gliese, Jonas Hoffmann, Paul G Lawrence, Frank D Sönnichsen, Anne Staubitz
We present the synthesis of a B-N analogue of polystyrene, poly(N-methyl-B-vinylazaborine) in high molecular weight (MW = 24.9 kDa). Furthermore, it was possible to prepare a copolymer with the C-C analogue. A thorough comparison between the polymers by NMR spectroscopy, TGA, DSC and GPC showed significant differences between these polymers.
January 5, 2017: Chemical Communications: Chem Comm
J Renaud, A Sarfehnia, S Woodings, J Kok, B van Asselen, J Wolthaus, B Raaymakers, J Seuntjens
PURPOSE: To evaluate the influence of a 1.5 T magnetic field (B-field) on the response of a small-scale graphite calorimeter probe (GPC) developed for use as a novel clinical reference dosimeter. Characterization of the GPC was also assessed in a hybrid MRI-linac (MRL) clinical prototype by performing absolute dosimetry in multiple detector orientations. METHODS: B-field influence was characterized using a variable-strength electromagnet system located 280 cm from the source of a clinical linac...
June 2016: Medical Physics
F Dong, H L Li, J Ma, B Zhou, Y Yu
Objective: To investigate the QuEChERS pretreatment method combined with on-line gel permeation chromatography-gas chromatography/mass spectrometry (GPC-GC/MS) for the determination of organophosphate pesticide and raticide in whole blood. Methods: The samples were pretreated with QuEChERS. A total of 1 ml acetonitrile was added to 1 ml whole blood sample for extraction, and 0.5 g sodium chloride was added. The mixture was oscillated for 15 seconds at a temperature of 4° C and centrifuged at a high speed of 12 000 r/min for 10 minutes...
October 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
Yongjun Ahn, Younghan Song, Hyungsup Kim, Seung-Yeop Kwak
This study focused on the influence of anion type on the depolymerization and its effect on the molecular state, dynamics and dispersity of cellulose. GPC and the van Gurp-Palmen plot showed that molar mass was more significantly decreased by 1-butyl-3-methylimidazolium chloride ([C4C1Im][Cl]) comparing to 1-butyl-3-methylimidazolium acetate ([C4C1Im][OAc]). Acid-catalyzed hydrolysis of cellulose in IL was proved using base titration which was monitored by conductivity and pH value. On the contrary to the depolymerization case, [C4C1Im][OAc] solution needed more base to be neutralized than [C4C1Im][Cl] solution...
March 1, 2017: Carbohydrate Polymers
Neelam Lohani, Himanshu Narayan Singh, Moganty R Rajeswari
HMGB1 (High mobility group box 1) protein has been an attractive therapeutic target for drug designing in various human cancers and inflammatory diseases. Overexpression of HMGB1 has been associated with all the seven hallmark of cancer. Actinomycin -D (Act-D) is a classical anticancer drug that binds GC-rich DNA with high affinity to cause transcription inhibition. In the present study we utilized the 21 nucleotide G rich DNA fragment in the regulatory region of hmgb1 gene for its ability to bind with Act-D...
December 29, 2016: Journal of Biomolecular Structure & Dynamics
J M Rumbo Prieto, M Romero Martín, D Bellido Guerrero, L Arantón Areosa, C D Raña Lama, F Palomar Llatas
Fundamento. La situación epidemiológica, sociosanitaria y económica que rodea al deterioro de la integridad cutánea supone un gran problema para el sistema sanitario. Su prevención y tratamiento crea incertidumbre y variabilidad profesional siendo prioritario contar con buenas Guías de Práctica Clínica (GPC). El objetivo fue conocer la calidad de las GPC sobre prevención y tratamiento de úlceras por presión (UPP), úlceras venosas de la pierna (UVP) y úlceras de pie diabético (UPD). Metodología...
December 30, 2016: Anales del Sistema Sanitario de Navarra
Wybe J M van der Kemp, Bertine L Stehouwer, Vincent O Boer, Peter R Luijten, Dennis W J Klomp, Jannie P Wijnen
In vivo water- and fat-suppressed (1) H magnetic resonance spectroscopy (MRS) and (31) P magnetic resonance adiabatic multi-echo spectroscopic imaging were performed at 7 T in duplicate in healthy fibroglandular breast tissue of a group of eight volunteers. The transverse relaxation times of (31) P metabolites were determined, and the reproducibility of (1) H and (31) P MRS was investigated. The transverse relaxation times for phosphoethanolamine (PE) and phosphocholine (PC) were fitted bi-exponentially, with an added short T2 component of 20 ms for adenosine monophosphate, resulting in values of 199 ± 8 and 239 ± 14 ms, respectively...
December 28, 2016: NMR in Biomedicine
A M Pour, N Masir, I M Rose
To assess the diagnostic utility of glypican-3 (GPC-3) in comparison to Hep Par 1 in the diagnosis of liver tumours, a cross-sectional study involving 66 resected liver tumours were tested for the protein expression of these markers by immunohistochemistry using monoclonal antibodies. Of the 66 cases, 26 (39.4%) were hepatocellular carcinoma (HCC), 4 (6.1%) were intrahepatic cholangiocarcinoma and 36 (54.5%) were metastatic tumours. Hep Par 1 and GPC-3 expressions in HCC were 24/26 (92.3%) and 19/26 (73.1%) respectively...
December 2016: Malaysian Journal of Pathology
Yan Liu, Kaihuan Zhang, Jinghong Ma, G Julius Vancso
Hydrogels with rapid and strong response to external stimuli and possessing high elasticity and strength have been considered as platform materials for numerous applications, e.g., in biomaterials engineering. Thermoresponsive hydrogels based on semi-interpenetrating polymer networks (semi-IPN) featuring N-isopropylacrylamide with copolymers of poly(N-isopropylacrylamide-co-hydroxyethyl methacrylate) p(NIPAM-HEMA) chains are prepared and described. The copolymer was characterized by FTIR, NMR, and GPC. The semi-IPN structured hydrogel and its responsive properties were evaluated by dynamic mechanical measurements, SEM, DSC, equilibrium swelling ratio, and dynamic deswelling tests...
December 27, 2016: ACS Applied Materials & Interfaces
M I Gaakeer, C L van den Brand, E Gips, J M van Lieshout, R Huijsman, R Veugelers, P Patka
OBJECTIVE: Gaining insight into key figures of emergency departments (EDs) in the Netherlands and developments in these figures. DESIGN: Longitudinal survey study. METHOD: Over the period from 2012 up to and including 2015, the following key data were surveyed: number of EDs, number of ED patients, ED patients' origin, number of hospital admissions from the ED and form of cooperation between ED and a general practitioner centre (GPC). RESULTS: An average of 96% of all EDs responded...
2016: Nederlands Tijdschrift Voor Geneeskunde
Zejun Xu, Yi Zhang, Qian Hu, Qiao Tang, Jiake Xu, Jianping Wu, Thomas Brett Kirk, Dong Ma, Wei Xue
The development of biocompatible vector for hydrophobic drug delivery remains a longstanding issue in cancer therapy. We design and synthesis a drug delivery system based on HPG modified β-CD (β-CD-HPG) by conjugating HPG branches onto β-CD core and its structure was confirmed by NMR, FTIR, GPC and solubility. In vitro biocompatibility tests showed that HPG modification significantly improved red blood cells morphology alteration and hemolysis cause by β-CD and β-CD-HPG displayed cell safety apparently in a wide range of 0...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Tariq Mahmud Tariq, Esmatullah Rasool
OBJECTIVE: To determine the frequency of pathogens causing bloodstream infections and evaluate their trends and antibiogram patterns among in-patients in a paediatric tertiary care centre. STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: French Medical Institute for Mothers and Children (FMIC), Kabul, Afghanistan in two phases, from January 2010 to December 2015. METHODOLOGY: Results of blood cultures from suspected cases of sepsis admitted in the FMIC, from January 2010 to December 2012 (Period-1), and from January 2013 to December 2015 (Period-2) were completed...
November 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Tristan Harper, Rimantas Slegeris, Irawan Pramudya, Hoyong Chung
A bioinspired, modular terpolymer adhesive, poly(N-methacryloyl-3,4-dihydroxyl-l-phenylalanine-co-9-(acryloyloxy)butyl anthracene-9-carboxylate-co-acrylic acid), has been synthesized containing three different functionalities: a photo-cross-linking segment, a wet interfacial adhesion segment, and a water-soluble segment. The synthesized adhesive polymer is the first example of a single-phase, photo-cross-linkable adhesive which does not require additional photoinitiator or other cross-linking agents. The terpolymer demonstrates strong adhesion when it swells in water and/or ethanol...
January 18, 2017: ACS Applied Materials & Interfaces
Azza A Matloub, Hadeer A Aglan, Sahar Salah Mohamed El Souda, Mona Elsayed Aboutabl, Amany Sayed Maghraby, Hanaa H Ahmed
OBJECTIVE: To explore the in vivo anticancer, anti-angiogenesis and immunomodulatory efficacies of the bioactive polysaccharide isolated from cold aqueous extract of Jania rubens (JCEM) and Pterocladia capillacea (PCEM) as well as hot aqueous extract of Enteromorpha intestinalis (EHEM) against hepatocellular carcinoma rat model (HCC) and to study their chemical composition. METHODS: The sugars and amino acids composition of the bioactive polysaccharides of JCEM, PCEM and EHEM were determined using gas liquid chromatography and amino acid analyzer, respectively...
December 2016: Asian Pacific Journal of Tropical Medicine
Michiel J van Veelen, Crispijn L van den Brand, Resi Reijnen, M Christien van der Linden
BACKGROUND: In 2013 a General Practitioner Cooperative (GPC) was introduced at the Emergency Department (ED) of our hospital. One of the aims of this co-located GPC was to improve throughput of the remaining patients at the ED. To determine the change in patient flow, we assessed the number of self-referrals, redirection of self-referrals to the GPC and back to the ED, as well as ward and ICU admission rates and length of stay of the remaining ED population. METHODS: We conducted a four months' pre-post comparison before and after the implementation of a co-located GPC with an urban ED in the Netherlands...
2016: World Journal of Emergency Medicine
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