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Jing Wang, Lei Zhao, Nina Ma, Juanjuan Che, Huihui Li, Bangwei Cao
RATIONALE: Cronkhite-Canada Syndrome (CCS) is an idiopathic, nonhereditary syndrome haracterized by gastrointestinal (GI) polyposis and ectodermal changes including alopecia, onychatrophia, and pigmentation. CCS colon polyps were previously considered to be benign neoplasms. However, serrated adenoma was reported to be associated with malignant neoplasms in some cases of gastric and colorectal carcinomas, and esophageal cancers. Although malignant colon and gastric cancer have been reported in CCS, reports of distant metastasis have been rare in CCS...
September 2017: Medicine (Baltimore)
Safoura Akbari-Alavijeh, Sabihe Soleimanian-Zad, Mahmoud Sheikh-Zeinoddin, Sarwar Hashmi
We isolated and characterized pistachio hull polysaccharides (PHP). The PHP was a heteropolysaccharide mainly contained 75.50% (w/w) total sugar and 9.51% (w/w) uronic acid. As determined by GPC analysis, the polysaccharide with a molecular weight of 3.71×10(6) D (83.2%) was the most dominant fraction. Moreover, HPLC analysis indicated that PHP was predominantly composed of xylose, glucose, arabinose, and fructose with a molar ratio of 1.00:2.50:19.67:28.81. FT-IR and NMR analysis also confirmed the results obtained by HPLC and characterized preliminary structure features of the PHP...
September 16, 2017: International Journal of Biological Macromolecules
Juan Yu, Chuanwei Lu, Chunpeng Wang, Jifu Wang, Yimin Fan, Fuxiang Chu
Cellulose-based thermoplastic elastomers (TPEs) have attracted considerable attention because of their rigid backbone, good mechanical properties, renewable nature and abundance. In the present study, sustainable TPEs based on ethyl cellulose (EC), fatty acid and furfural were generated by the combination of ATRP and "click chemistry". To fabricate sustainable TPEs with higher toughness, a range of polymers, including mono random-copolymer poly(tetrahydrofurfuryl methacrylate-co-lauryl methacrylate) (P(THFMA-co-LMA), dual polymer side chains PTHFMA and PLMA, and mono-block copolymer PTHFMA-b-PLMA, were designed as side chains to fabricate EC brush copolymers with random, dual or block side chain architectures using the "grafting from" and "grafting onto" methods...
November 15, 2017: Carbohydrate Polymers
Chi-Hung Huang, Sheng-Yang Lee, Sonida Horng, Louis-Georges Guy, Ting-Bin Yu
The degradation of Mirage Bioresorbable Microfiber Scaffold was evaluated in vitro and in vivo. The degradation in polymer molecular weight (MW), strut morphology, and integrity was accessed using gel permeation chromatography (GPC), X-ray micro-computed tomography (micro-CT) evaluation. To simulate the physiological degradation in vitro, scaffolds were deployed in silicone mock vessels connected to a peristaltic pumping system, which pumps 37°C phosphate-buffered saline (PBS, pH 7.4) at a constant rate. At various time points (30D, 60D, 90D, 180D, 270D, and 360D), the MW of microfibers decreased to 57...
September 18, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Pradipta Kumar Das, Dexter N Dean, April L Fogel, Fei Liu, Brooks A Abel, Charles L McCormick, Eugenia Kharlampieva, Vijayaraghavan Rangachari, Sarah E Morgan
GM1 ganglioside is known to promote amyloid-β (Aβ) peptide aggregation in Alzheimer's disease. The roles of the individual saccharides and their distribution in this process are not understood. Acrylamide-based glycomonomers with either β-D-glucose or β-D-galactose pendant groups were synthesized to mimic the stereochemistry of saccharides present in GM1 and characterized via 1H NMR and electrospray ionization mass spectrometry. Glycopolymers of different molecular weights were synthesized by aqueous reversible addition fragmentation chain transfer (aRAFT) polymerization and characterized by NMR and GPC...
September 11, 2017: Biomacromolecules
Chao Zhang, Meng-Qi Ma, Ting-Ting Chen, He Zhang, Deng-Feng Hu, Bai-Heng Wu, Jian Ji, Zhi-Kang Xu
Surface modification has been well recognized as a promising strategy to design and exploit diversified functional materials. However, conventional modification strategies usually suffer from complicated manufacture procedures and lack of universality. Herein, a facile, robust, and versatile approach is proposed to achieve the surface functionalization using dopamine and acrylate monomers via a one-step polymerization and codeposition process. The gel permeation chromatography, proton nuclear magnetic resonance, liquid chromatography-mass spectrometry, and UV-visible spectra results indicate that dopamine possesses the capability of triggering the polymerization of acrylate monomers into high-molecular-weight products, and the inherent adhesive ability of polydopamine can assist the polymerized products to deposit on various substrates...
September 19, 2017: ACS Applied Materials & Interfaces
Xudong Liu, Chenghui Zhang, Ke Li, Qi Zhang
This paper addresses the current control of permanent magnet synchronous motor (PMSM) for electric drives with model uncertainties and disturbances. A generalized predictive current control method combined with sliding mode disturbance compensation is proposed to satisfy the requirement of fast response and strong robustness. Firstly, according to the generalized predictive control (GPC) theory based on the continuous time model, a predictive current control method is presented without considering the disturbance, which is convenient to be realized in the digital controller...
September 6, 2017: ISA Transactions
Bing Wang, Tian-Ying Chen, Han-Min Wang, Han-Yin Li, Chuan-Fu Liu, Jia-Long Wen
The alcoholic depolymerization and Mannich reaction were conducted to improve the chemical activity of biorefinery technical lignins and introduce amino groups into lignins, respectively. To understand the chemical structural transformations and examine the reaction mechanism, GPC and solution-state NMR techniques were performed. Element analysis was also used to quantify the amount of amine groups. The NMR characterization the depolymerized lignins indicated of the depolymerization, demethoxylation, and bond cleavage of linkages occurred during the depolymerization process...
September 6, 2017: International Journal of Biological Macromolecules
Vasanthan Ravichandran, Rajani Kant Rai, Venkitasamay Kesavan, A Jayakrishnan
A new approach for the design and synthesis of cyclic N-halamine polymers having anti-bacterial activity based on a vinyl derivative of tyrosine-derived hydantoin is reported. The synthesis of N-halamine polymers generally involves the chemical modification of 5,5'-disubstituted hydantoin to introduce polymerizable vinyl moieties thereby restricting the halogen capture only on the amide nitrogen. Here we show the possibility of synthesizing vinyl monomers of N-halamine from α-amino acids wherein both the amide and imide nitrogens are available for halogen capture...
September 7, 2017: Journal of Biomaterials Science. Polymer Edition
Yanyu Shen, Guijin He, Yongsheng Guo, Hujun Xie, Wenjun Fang
Hyperbranched polyglycerol (HPG) is modified with dodecanethiol (DS) via the "thiol-ene" click reaction to obtain an amphiphilic product DSHPG. The molecular structures of DSHPG samples are characterized by NMR, FTIR, and GPC, and the thermal behaviors are characterized by DSC and TGA. Gold nanoparticles (Au NPs) are prepared with DSHPG as the stabilizer and surface-modification reagent. The size of Au NPs can be tuned by changing the molecular weight of HPG. It is observed that the HPG molecular weights of 1123, 3826, and 55,075 lead to the NP diameters of 4...
September 6, 2017: Nanoscale Research Letters
Parvin Mahdaviani, Saeed Bahadorikhalili, Mona Navaei-Nigjeh, Seyed Yaser Vafaei, Mehdi Esfandyari-Manesh, Amir Hossein Abdolghaffari, Zahra Daman, Fatemeh Atyabi, Mohammad Hossein Ghahremani, Mohsen Amini, Afsaneh Lavasanifar, Rassoul Dinarvand
Metastatic cancer is responsible for 90% of deaths in world. Usage of nano-carriers improve the delivery and efficacy of chemotherapeutic agents. Recent studies suggest that decoration of the surface of nano-carriers with various targeting agents may further improve their overall therapeutic efficacy. Using specified peptides in targeted drug delivery is a key point in recent researches. In this study, tumor metastasis targeting (TMT) homing peptide was applied as a targeting group to improve specific drug delivery to tumor cells...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Munehiro Furuichi, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara, Isao Miyairi
BACKGROUND: Bloodstream infection (BSI) is a major cause of morbidity and mortality after pediatric liver transplantation (LT). However, most studies have focused on BSI occurring within a few months after LT. In this study, we evaluated the characteristics of BSI occurring beyond six months after pediatric LT. METHODS: We conducted a retrospective cohort study at a pediatric LT center in Japan from November 2005 to March 2016. We evaluated the causative organisms and site of late-onset BSI in children ≤18 years of age...
August 28, 2017: Pediatric Infectious Disease Journal
Fei Tong, Hua Zhang
BACKGROUND/AIMS: The aim of this study was to assess the effect of human hepatocyte growth factor (hHGF)-loaded poly (ethylene glycol)-b-brush poly (l-lysine) (PEG-b-P(ELG-g-PLL)) copolymer on ischemia/reperfusion (I/R) injury to different organs. METHODS: The isoelectric point (pI) of hHGF is 5.5, and hHGF combined with PEG-b-P(ELG-g-PLL) copolymer via electrostatic interactions at pH 7.4. The synthesized PEG-b-P(ELG-g-PLL) copolymer was analyzed using 1H nuclear magnetic resonance (1H NMR) and gel permeation chromatography (GPC)...
August 30, 2017: Kidney & Blood Pressure Research
Ali Ramazani, Mojtaba Keramati, Hojat Malvandi, Hossein Danafar, Hamidreza Kheiri Manjili
PURPOSE: Artemisinin (ART) has anti-inflammatory, antimicrobial, antioxidant, anti-amyloid, and anti-malarial effects, but its application is limited due to its low water solubility and poor oral bioavailability. In this study, the bioavailability, water solubility and anti-plasmodial property of ART were improved by PCL-PEG-PCL triblock copolymers. METHODS: The structure of the copolymers was characterized by (1)HNMR, FT-IR, DSC and GPC techniques. ART was encapsulated within micelles by a single-step nano-precipitation method, leading to the formation of ART-loaded PCL-PEG-PCL micelles...
August 30, 2017: Pharmaceutical Development and Technology
Lan Yao, Haitao Yang, Chang Geun Yoo, Xianzhi Meng, Mi Li, Yunqiao Pu, Arthur J Ragauskas, Robert W Sykes
Broussonetia papyrifera, known as paper mulberry, is a potential feed stock for bioethanol production because of its cellulose-rich composition. Lignin in dilute acid pretreated Broussonetia papyrifera was fractionated to three different fractions, and their physiochemical properties were determined by FT-IR, GPC and NMR analyses. Different structural characteristics were observed from each lignin fraction. Cellobiohydrolases I (CBH) adsorption to each lignin was understood by the lignin properties. The results showed that aliphatic hydroxyl groups in lignin showed positive correlations with the maximum binding ability of CBH onto lignin samples...
November 2017: Bioresource Technology
Jing Wang, Tiefan Huang, Lin Zhang, Qiming Jimmy Yu, Li'an Hou
A graphene oxide-polydopamine-(β-cyclodextrin) (GPC) ultrafiltration membrane was fabricated by using the method of drop-coating combined with vacuum filtration. The prepared GPC membrane was characterized with FTIR and XPS spectrophotometry and evaluated for its performances for the rejection of organic molecules (methylene blue) and adsorption of trace heavy metals (Pb(2+)) from aqueous solutions. The membrane exhibited an excellent rejection coefficient of 99.2% for methylene blue and the permeation flux was 12 L m(-2) h(-1) at 0...
September 8, 2017: Environmental Technology
Gou Kamochi, Norihisa Akiba, Hiroyuki Tanimoto, Toshinari Nakamura, Shunsuke Minakuchi
This study aimed to clarify how composition and water immersion of home reliners affect the attenuation of the transmitted load. To conduct a transmitted load measurement, we used three different home reliners (Tafugurippu Pink A, Liodent Pink, and Cushion Correct), which were combined acrylic resin disks. They were immersed in distilled water and then placed on a silicone quasimucosa (φ20×1.5 mm), which was set on a pressure sensor (φ8×0.35 mm), followed by the application of static load. Subsequently, gel permeation chromatography (GPC) and gas chromatography (GC) were used to clarify the composition of each home reliner...
August 25, 2017: Dental Materials Journal
T Wersig, M C Hacker, J Kressler, K Mäder
The linear biodegradable polyester poly(glycerol adipate) (PGA) was synthesized via enzymatic polycondensation using lipase B from Candida antarctica (CAL-B). Every monomer unit of PGA possesses a pendant hydroxyl group which is responsible for the hydrophilic character and moisture swelling. These OH groups were esterified to different degrees with the anti-inflammatory drug indomethacin in order to create a prodrug with a pH-sensitive linker for modified drug release. The structure of the conjugates was determined via ATR FT-IR spectroscopy, NMR spectroscopy, GPC and UV/VIS spectroscopy...
August 23, 2017: International Journal of Pharmaceutics
Laura Kaisa Kristiina Svärd, Matti Putkonen, Eija Kenttä, Timo Sajavaara, Fabian Krahl, Maarit Karppinen, Kevin Van de Kerckhove, Christophe Detavernier, Pekka Simell
Molecular Layer Deposition (MLD) is an increasingly used deposition technique for producing thin coatings consisting of purely organic or hybrid inorganic-organic materials. When organic materials are prepared, low deposition temperatures are often required to avoid decomposition, thus causing problems with low vapour pressure precursors. Monofunctional compounds have higher vapour pressures than traditional bi- or tri-functional MLD precursors, but do not offer the required functional groups for continuing the MLD growth in subsequent deposition cycles...
August 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Wen-Xia Wu, Dan Liu, Yi-Wen Wang, Chuan Wang, Chuan Yang, Xing-Zhou Liu, Li-Fang Mai, Meng Ren, Li Yan
Diabetic foot and subsequent diabetic ulcer infections are the most devastating complication of diabetes. This study was conducted to explore the bacterial spectrum, sensitivity of microbials, and analysis of the empirical antibiotic regimens in our health center. The study included patients with diabetic foot ulcer infection (DFI) seen from 2009 to 2014. The patients included had all information covering the physical examination, laboratory tests, and image examinations. We sent appropriately obtained specimens for culture prior to starting empirical antibiotic therapy in all participants...
August 1, 2017: International Journal of Lower Extremity Wounds
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