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https://www.readbyqxmd.com/read/28542743/neuroimaging-cardiovascular-physiology-and-functional-outcomes-in-infants-with-congenital-heart-disease
#1
REVIEW
Nathalie H P Claessens, Christopher J Kelly, Serena J Counsell, Manon J N L Benders
This review integrates data on brain dysmaturation and acquired brain injury using fetal and neonatal magnetic resonance imaging (MRI), including the contribution of cardiovascular physiology to differences in brain development, and the relationship between brain abnormalities and subsequent neurological impairments in infants with congenital heart disease (CHD). The antenatal and neonatal period are critical for optimal brain development; the developing brain is particularly vulnerable to haemodynamic disturbances during this time...
May 19, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28540201/cold-dialysis-and-its-impact-on-renal-patients-health-an-evidence-based-mini-review
#2
REVIEW
Giorgos K Sakkas, Argiro A Krase, Christoforos D Giannaki, Christina Karatzaferi
Chronic renal disease is associated with advanced age, diabetes, hypertension, obesity, musculoskeletal problems and cardiovascular disease, the latter being the main cause of mortality in patients receiving haemodialysis (HD). Cooled dialysate (35 °C-36 °C) is recently employed to reduce the incidence of intradialytic hypotension in patients on chronic HD. The studies to date that have evaluated cooled dialysate are limited, however, data suggest that cooled dialysate improves hemodynamic tolerability of dialysis, minimizes hypotension and exerts a protective effect over major organs including the heart and brain...
May 6, 2017: World Journal of Nephrology
https://www.readbyqxmd.com/read/28539745/effect-of-tamarindus-indica-l-and-manihot-esculenta-extracts-on-antibiotic-resistant-bacteria
#3
Zenon Machado Lima, Lenilson Santos da Trindade, Genelane Cruz Santana, Francine Ferreira Padilha, Marcelo da Costa Mendonça, Luiz Pereira da Costa, Jorge A López, Maria Lucila Hernández Macedo
BACKGROUND: The chemical composition of plants used in traditional medicine exhibits biologically active compounds, such as tannins, flavonoids, and alkaloids and becomes a promising approach to treat microbial infections, mainly with drug-resistant bacteria. OBJECTIVE: The aim of the present study was to evaluate the hydroethanolic leaf extracts of Tamarindus indica (tamarind) and Manihot esculenta (cassava) as antimicrobial potential against Pseudomonas aeruginosa clinical isolated and Methicillin-resistant Staphylococcus aureus...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28539079/a-cognitive-stressor-for-event-related-potential-studies-the-portland-arithmetic-stress-task
#4
Rachel Atchley, Roger Ellingson, Daniel Klee, Tabatha Memmott, Barry Oken
In this experiment, we developed and evaluated the Portland Arithmetic Stress Task (PAST) as a cognitive stressor to evaluate acute and sustained stress reactivity for event-related potential (ERP) studies. The PAST is a titrated arithmetic task adapted from the Montreal Imaging Stress Task (MIST), with added experimental control over presentation parameters, improved and synchronized acoustic feedback, and generation of timing markers needed for physiological analyses of real-time brain activity. Thirty-one older adults (M = 60 years) completed the PAST...
May 24, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28538394/123i-ioflupane-brain-spect-and-123i-mibg-cardiac-planar-scintigraphy-combined-use-in-uncertain-parkinsonian-disorders
#5
Susanna Nuvoli, Angela Spanu, Maria Rita Piras, Antonio Nieddu, Aldo Mulas, Gaia Rocchitta, Grazia Galleri, Pier Andrea Serra, Giuseppe Madeddu
We evaluated the clinical usefulness of the combined use of I-ioflupane brain single photon emission computed tomography (SPECT) and I-metaiodobenzylguanidine (MIBG) cardiac scintigraphy in discriminating uncertain parkinsonism with vascular lesions in striatal nuclei at magnetic resonance imaging (MRI). Forty-three consecutive patients with uncertain parkinsonism and vascular lesions at MRI in striatal nuclei were retrospectively evaluated; the uncertain differential diagnosis was between Parkinson's disease and vascular parkinsonism (PD/VP) in 22 patients, between PD and other neurodegenerative parkinsonism (PD/PS) in 11 patients and between Lewy body dementia and Alzheimer disease (LBD/AD) in the remaining 10 cases...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28537443/pregnancy-associated-plasma-protein-a-papp-a-and-the-proform-of-the-eosinophil-major-basic-protein-prombp-are-associated-with-increased-risk-of-death-in-heart-failure-patients
#6
Maja Dembic, Paula L Hedley, Christian Torp-Pedersen, Lars Køber, Michael Christiansen
Risk stratification and patient management in heart failure (HF) is difficult due to the unpredictable progression of the disease, necessitating the development of reliable diagnostic biomarkers to facilitate decision-making in clinical practice. Pregnancy-associated plasma protein-A (PAPP-A) is a marker of arteriosclerotic heart disease. PAPP-A is a serum protease, which is involved in the insulin-like growth factor 1 (IGF-1) axis where it is inhibited by the proform of the eosinophil major basic protein (proMBP)...
May 24, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28527194/biodistribution-and-excretion-of-colloidal-gold-nanoparticles-after-intravenous-injection-effects-of-particle-size
#7
Issei Takeuchi, Sho Nobata, Naoto Oiri, Keishiro Tomoda, Kimiko Makino
BACKGROUND: Inorganic gold nanoparticles (NPs) have a huge potential in targeted drug delivery. Simple preparation and surface modification procedure with their special physicochemical properties of gold NPs attract their use such as tumor targeting and the detection of cancerous cell. OBJECTIVE: Various studies were reported, however, details of biodistribution profile of gold NPs were not enough evaluated. We have studied biodistribution profile of gold NPs having various particle sizes (20, 50 and 100 nm)...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28522136/impact-of-red-blood-cell-distribution-width-on-non-cardiac-mortality-in-patients-with-acute-decompensated-heart-failure-with-preserved-ejection-fraction
#8
Ryo Imai, Yusuke Uemura, Takahiro Okumura, Kenji Takemoto, Tomohiro Uchikawa, Masayoshi Koyasu, Shinji Ishikawa, Satoshi Iwamiya, Yuta Ozaki, Rei Shibata, Masato Watarai, Toyoaki Murohara
BACKGROUND: The prognostic impact of red blood cell distribution width (RDW) on adverse outcomes in patients with heart failure with preserved ejection fraction (HFpEF) is unclear. We investigated the association between RDW values at admission and long-term prognosis in patients with acute decompensated HFpEF. METHODS: The present study enrolled 278 consecutive patients with acute decompensated HFpEF, whose RDW levels were measured at admission. We divided enrolled patients into 2 groups according to RDW value and investigated the association between RDW and patients' mortality...
May 15, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28504123/erythropoietin-and-small-molecule-agonists-of-the-tissue-protective-erythropoietin-receptor-increase-fxn-expression-in-neuronal-cells-in-vitro-and-in-fxn-deficient-kiko-mice-in-vivo
#9
James L Miller, Myriam Rai, Normand L Frigon, Massimo Pandolfo, Juha Punnonen, Jeffrey R Spencer
Friedreich's ataxia (FRDA) is a progressive neurodegenerative disease caused by reduced levels of the mitochondrial protein frataxin (FXN). Recombinant human erythropoietin (rhEPO) increased FXN protein in vitro and in early clinical studies, while no published reports evaluate rhEPO in animal models of FRDA. STS-E412 and STS-E424 are novel small molecule agonists of the tissue-protective, but not the erythropoietic EPO receptor. We find that rhEPO, STS-E412 and STS-E424 increase FXN expression in vitro and in vivo...
May 11, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28499710/impact-of-prealbumin-on-mortality-and-hospital-readmission-in-patients-with-acute-heart-failure
#10
Jonathan Franco, Francesc Formiga, Joan-Carles Trullas, P Salamanca Bautista, Alicia Conde, Luis Manzano, Raúl Quirós, Álvaro González Franco, Alejandro Martín Ezquerro, Manuel Montero-Pérez-Barquero
BACKGROUND: Prealbumin is a maker of nutritional status and inflammation of potential prognostic value in acute heart failure (HF). The aim of this study is to evaluate if low prealbumin levels on admission predict mortality and readmissions in patients with acute HF. METHOD: We conducted a prospective observational cohort study including 442 patients hospitalized for acute HF. Patients were classified in two groups according to prealbumin levels: "normal" prealbumin (>15mg) and "low" prealbumin (≤15mg/dL)...
May 9, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28496945/gestational-exposure-to-silymarin-increases-susceptibility-of-balb-c-mice-fetuses-to-apoptosis
#11
Mahbobe Gholami, Seyed Adel Moallem, Mohammad Afshar, Leila Etemad, Gholamreza Karimi
BACKGROUND: Silymarin is a flavonolignan that has been the subject of research to evaluate the beneficial properties for decades. Silymarin has been known for its potent cytoprotective, hepatoprotective and antioxidant activities. The goal of the present study was to gain a deeper understanding of possible molecular mechanisms of apoptosis of the injuries induced by silymarin on BALB/c mice fetuses. METHODS: The present experimental study was carried out in virgin female BALB/c mice...
April 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/28493801/imaging-of-hydatid-disease-with-a-focus-on-extrahepatic-involvement
#12
Eugenio Zalaquett, Christine Menias, Francisco Garrido, Matías Vargas, José Francisco Olivares, Daniel Campos, Natalia Pinochet, Antonio Luna, Nirvikar Dahiya, Álvaro Huete
Hydatid disease (HD) is a parasitic infection caused by the larvae of a tapeworm that is endemic to many regions around the world-South America, Africa, and Asia, in particular. Humans are infected as intermediate hosts in the parasite's life cycle; thus, HD can be seen in persons living in areas where animal husbandry is practiced. However, owing to the varied patterns of migration and immigration during the past several decades, HD can be diagnosed in individuals living anywhere. The liver is the most common organ involved, with hepatic HD accounting for the majority of published cases...
May 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28490726/plasma-long-noncoding-rna-urothelial-carcinoma-associated-1-predicts-poor-prognosis-in-chronic-heart-failure-patients
#13
Xuejing Yu, Tong Zou, Lihui Zou, Junhua Jin, Fei Xiao, Jiefu Yang
BACKGROUND Chronic heart failure (CHF) is a leading cause of death worldwide. A long noncoding RNA (lncRNA) named urothelial carcinoma associated 1 (UCA1) is important in multiple diseases. However, the role of UCA1 in CHF is still unknown. Our study investigated whether UCA1 could be applied as an ideal marker to diagnose and evaluate prognosis in CHF. MATERIAL AND METHODS Total plasma RNA was extracted from 67 CHF patients and 67 controls. Quantitative real-time polymerase chain reaction was used to determine the plasma level of UCA1...
May 11, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28490337/effect-of-sitagliptin-on-the-echocardiographic-parameters-of-left-ventricular-diastolic-function-in-patients-with-type-2-diabetes-a-subgroup-analysis-of-the-prologue-study
#14
Hirotsugu Yamada, Atsushi Tanaka, Kenya Kusunose, Rie Amano, Munehide Matsuhisa, Hiroyuki Daida, Masaaki Ito, Hiroyuki Tsutsui, Mamoru Nanasato, Haruo Kamiya, Yasuko K Bando, Masato Odawara, Hisako Yoshida, Toyoaki Murohara, Masataka Sata, Koichi Node
BACKGROUND: Diabetes is associated closely with an increased risk of cardiovascular events, including diastolic dysfunction and heart failure that leads to a shortening of life expectancy. It is therefore extremely valuable to evaluate the impact of antidiabetic agents on cardiac function. However, the influence of dipeptidyl peptidase 4 inhibitors on cardiac function is controversial and a major matter of clinical concern. We therefore evaluated the effect of sitagliptin on echocardiographic parameters of diastolic function in patients with type 2 diabetes as a sub-analysis of the PROLOGUE study...
May 11, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28489954/astaxanthin-prevented-oxidative-stress-in-heart-and-kidneys-of-isoproterenol-administered-aged-rats
#15
Mohammad Nazmul Alam, Md Murad Hossain, Md Mizanur Rahman, Nusrat Subhan, Md Abdullah Al Mamun, Anayt Ulla, Hasan Mahmud Reza, Md Ashraful Alam
The objective of this study was to investigate the effect of astaxanthin on isoproterenol (ISO)-induced myocardial infarction and cardiac hypertrophy in rats. To evaluate the effect of astaxanthin on ISO-induced cardiac dysfunction, 18 aged Long Evans male rats were evenly divided into three groups. Group I (Control group) was given only the laboratory-ground food and normal water. Group II (ISO group) was administered ISO at a dose of 50 mg/kg subcutaneously (SC) twice a week for two weeks. Group III (Astaxanthin + ISO group) was treated with astaxanthin (25 mg/kg) orally every day and ISO 50 mg/kg SC twice a week for two weeks...
May 10, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28485200/assessment-of-early-treatment-response-by-rapid-cardiothoracic-ultrasound-in-acute-heart-failure-cardiac-filling-pressures-pulmonary-congestion-and-mortality
#16
Jonas Öhman, Veli-Pekka Harjola, Pasi Karjalainen, Johan Lassus
BACKGROUND: It is unclear how to optimally monitor acute heart failure (AHF) patients. We evaluated the timely interplay of cardiac filling pressures, brain natriuretic peptides (BNPs), lung ultrasound (LUS) and symptoms during AHF treatment. METHODS: We enrolled 60 patients who had been hospitalised for AHF. Patients were examined with a rapid cardiothoracic ultrasound (CaTUS) protocol, combining LUS and focused echocardiographic evaluation of cardiac filling pressures (i...
May 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28484930/heart-shaped-bilateral-medullary-pyramidal-infarction-as-a-pathognomonic-finding-of-anterior-spinal-artery-occlusion
#17
Sammy Searcy, Oluwaseun O Akinduro, Andrew Spector, Jang W Yoon, Benjamin L Brown, William D Freeman
BACKGROUND: Unilateral anterior spinal artery (ASA) occlusion resulting in bilateral medullary pyramidal (BMP) infarction is a rare and devastating stroke subtype. We present two cases highlighting the diagnostic and clinical challenges of BMP infarction. METHODS: Case reports and literature review. RESULTS: A 57-year-old man rapidly had severe vomiting and diarrhea 2 h after a meal. Examination revealed bulbar weakness and areflexic tetraplegia...
May 8, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28482805/management-of-potentially-life-threatening-emergencies-at-74-primary-level-hospitals-in-mongolia-results-of-a-prospective-observational-multicenter-study
#18
Naranpurev Mendsaikhan, Davaa Gombo, Ganbold Lundeg, Christian Schmittinger, Martin W Dünser
BACKGROUND: While the capacities to care for and epidemiology of emergency and critically ill patients have been reported for secondary and tertiary level hospitals in Mongolia, no data exist for Mongolian primary level hospitals. METHODS: In this prospective, observational multicenter study, 74 primary level hospitals of Mongolia were included. We determined the capacities of these hospitals to manage medical emergencies. Furthermore, characteristics of patients presenting with potentially life-threatening emergencies to these hospitals were evaluated during a 6 month period...
May 8, 2017: BMC Emergency Medicine
https://www.readbyqxmd.com/read/28482255/molecular-cloning-characterization-and-expression-analysis-of-metallothionein-in-the-liver-of-the-teleost-acrossocheilus-fasciatus-exposed-to-cadmium-chloride
#19
Guo-Di Liu, Zhang Sheng, Cong-Cong Hou, Jie Ni, Ying-Li Han, You-Fa Wang, Yang Zhou, Su-Yan Fu, Jun-Quan Zhu
Metallothionein (MT) has a characteristic molecular structure with a cysteine-rich content. This unique structure provides metal-binding and redox capabilities and promoting metal homeostasis and detoxification in living animals. In order to evaluate the effects of cadmium (Cd) on hepatic MT expression in the liver of Acrossocheilus fasciatus, we obtained the complete cDNA of the A. fasciatus liver MT for the first time. The MT cDNA contains a 605-bp sequence, which codes for 60 amino acids. Protein alignment showed that the similarity between MT protein sequences of A...
March 29, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28480853/-contemporary-approach-to-diagnosis-of-subclinical-heart-failure
#20
A Azaraksh, G Ivanov, N Bulanova, L Stazhadze, M Nikolaeva, V Vostrikov
Treatment of congestive heart failure (CHF) remains one of the challenging problems in cardiology. In recent years, the method of multifrequency bio-impendancemetry is used in patients with CHF for the assessment of water imbalance and determination of its severity. The aim of the study was to determine the diagnostic capabilities of bio-impendancemetry in evaluation of the early manifestations of CHF. The study included 92 healthy individuals, and 335 patients who were hospitalized in the cardiology department with NYHA I-II functional class (FC) of chronic CHF...
March 2017: Georgian Medical News
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