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https://www.readbyqxmd.com/read/28296344/genome-wide-analysis-identifies-an-african-specific-variant-in-sema4d-associated-with-body-mass-index
#1
Guanjie Chen, Ayo P Doumatey, Jie Zhou, Lin Lei, Amy R Bentley, Olufemi Fasanmade, Godfrey Okafor, Benjamin Eghan, Kofi Agyenim-Boateng, Albert Amoah, Clement Adebamowo, Joseph Acheampong, Thomas Johnson, Johnnie Oli, Daniel Shriner, Adebowale A Adeyemo, Charles N Rotimi
OBJECTIVE: The prevalence of obesity varies between ethnic groups. No genome-wide association study (GWAS) for body mass index (BMI) has been conducted in continental Africans. METHODS: We performed a GWAS for BMI in 1,570 West Africans (WA). Replication was conducted in independent samples of WA (n = 1,411) and African Americans (AA) (n = 9,020). RESULTS: We identified a novel genome-wide significant African-specific locus for BMI (SEMA4D, rs80068415; minor allele frequency = 0...
March 13, 2017: Obesity
https://www.readbyqxmd.com/read/28151098/-you-feel-you-have-to-be-made-of-steel-the-strong-black-woman-health-and-well-being-in-nova-scotia
#2
Josephine B Etowa, Brenda L Beagan, Felicia Eghan, Wanda Thomas Bernard
The "strong Black woman" construct has been well-documented in the United States as both an aspirational icon and a constricting burden for African-heritage women. It has not been examined among African-Canadians. Drawing on qualitative interviews and standardized measures with 50 African-heritage women in Eastern Canada, our analysis reveals their perceptions of the construct as both strongly endorsed as a source of cultural pride, yet also acknowledged to take a terrible toll on health and well-being. The construct arises from and directly benefits racism...
April 2017: Health Care for Women International
https://www.readbyqxmd.com/read/28143459/frequency-and-determinants-of-thyroid-autoimmunity-in-ghanaian-type-2-diabetes-patients-a-case-control-study
#3
COMPARATIVE STUDY
Osei Sarfo-Kantanka, Fred Stephen Sarfo, Eunice Oparebea Ansah, Ernest Yorke, Josephine Akpalu, Bernard C Nkum, Benjamin Eghan
BACKGROUND: The link between type 1 diabetes and thyroid autoimmunity is well described. The same cannot be said for type 2 diabetes where results have been mixed so far. We investigated the prevalence and determinants of thyroid autoimmunity among Ghanaian type 2 diabetes patients. METHODS: This was a case-control study involving 302 type 2 diabetes patients and 310 non - diabetic controls aged 40-80 years. Anthropometric and blood pressure measurements were obtained...
January 17, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27900971/chronic-kidney-disease-stages-among-diabetes-patients-in-the-cape-coast-metropolis
#4
Richard K D Ephraim, Eric Arthur, W K B A Owiredu, Prince Adoba, Hope Agbodzakey, Ben A Eghan
Diabetes patients worldwide are at a high risk of chronic kidney disease (CKD) which affects their quality of life and increases the risk of early death. This study used the new kidney disease improving global outcomes (KDIGO) guidelines to establish the prevalence and also identify the factors associated with CKD among diabetes patients in the Cape Coast Metropolis. Two hundred (200) diabetes patients were randomly recruited from the diabetic clinic of the Cape Coast Teaching Hospital from January to April 2014...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27884381/elevated-adiponectin-but-varied-response-in-circulating-leptin-levels-to-falciparum-malaria-in-type-2-diabetics-and-non-diabetic-controls
#5
COMMENT
Samuel Acquah, Benjamin Ackon Eghan, Johnson Nyarko Boampong
BACKGROUND: To investigate effects of falciparum malaria on circulating levels of leptin and adiponectin in type 2 diabetes mellitus (T2DM) and non-diabetic controls in relation to measures of adiposity. METHODS: Levels of leptin and adiponectin were measured in 100 type 2 diabetics and 100 age-matched controls before and during falciparum malaria in a 2-year prospective study. Also, waist circumference (WC), weight, height and hip circumference were measured. Body mass index (BMI) and waist-to-hip ratio (WHR) were computed...
October 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27875539/secular-trends-in-admissions-and-mortality-rates-from-diabetes-mellitus-in-the-central-belt-of-ghana-a-31-year-review
#6
Osei Sarfo-Kantanka, Fred Stephen Sarfo, Eunice Oparebea Ansah, Benjamin Eghan, Nana Kwame Ayisi-Boateng, Emmanuel Acheamfour-Akowuah
INTRODUCTION: Diabetes Mellitus is currently a leading cause of morbidity and mortality throughout the world, particularly in sub-Saharan Africa where a significant proportion of diabetes cases are now found. Longitudinal profiling of in-patient admissions and mortality trends from diabetes provide useful insights into the magnitude of the burden of diabetes, serve as a sentinel on the state of out-patient diabetes care and provide effective tools for planning, delivering and evaluating the health care needs relating to the disease in sub-Saharan Africa...
2016: PloS One
https://www.readbyqxmd.com/read/27303364/impact-of-type-2-diabetes-on-impaired-kidney-function-in-sub-saharan-african-populations
#7
Sally N Adebamowo, Adebowale A Adeyemo, Fasil Tekola-Ayele, Ayo P Doumatey, Amy R Bentley, Guanjie Chen, Jie Zhou, Daniel Shriner, Olufemi Adetola Fasanmade, Godfrey Okafor, Benjamin Eghan, Kofi Agyenim-Boateng, Jokotade Adeleye, Williams Balogun, Albert G Amoah, Samuel Owusu, Joseph Acheampong, Thomas Johnson, Johnnie Oli, Clement A Adebamowo, Charles N Rotimi
BACKGROUND: Diabetes is a leading risk factor for impaired kidney function, an indicator of chronic kidney disease. The aim of this study was to examine the association between type 2 diabetes (T2D) and impaired kidney function among adults in sub-Saharan Africa (SSA). METHODS: Participants were enrolled from Ghana, Kenya, and Nigeria. Impaired kidney function was based on an estimated glomerular filtration rate <60 ml/min/1.73 m(2). Using logistic regression models, we conducted case-control analyses to estimate the multivariate-adjusted association of T2D and kidney function...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27298824/increased-oxidative-stress-and-inflammation-independent-of-body-adiposity-in-diabetic-and-nondiabetic-controls-in-falciparum-malaria
#8
Samuel Acquah, Johnson Nyarko Boampong, Benjamin Ackon Eghan Jnr
Information on the extent to which oxidative stress and inflammation occur in the presence of falciparum malaria and type 2 diabetes mellitus in the same individual is limited. This study sought to investigate the extent of inflammation and oxidative stress in adult uncomplicated malaria by measuring fasting levels of lipid peroxides, C-reactive protein (CRP), and total antioxidant power (TAP) before and during falciparum malaria, in 100 respondents with type 2 diabetes and 100 age-matched controls in the Cape Coast metropolis of Ghana...
2016: BioMed Research International
https://www.readbyqxmd.com/read/26635871/evaluation-of-genome-wide-association-study-associated-type-2-diabetes-susceptibility-loci-in-sub-saharan-africans
#9
Adebowale A Adeyemo, Fasil Tekola-Ayele, Ayo P Doumatey, Amy R Bentley, Guanjie Chen, Hanxia Huang, Jie Zhou, Daniel Shriner, Olufemi Fasanmade, Godfrey Okafor, Benjamin Eghan, Kofi Agyenim-Boateng, Jokotade Adeleye, Williams Balogun, Abdel Elkahloun, Settara Chandrasekharappa, Samuel Owusu, Albert Amoah, Joseph Acheampong, Thomas Johnson, Johnnie Oli, Clement Adebamowo, Francis Collins, Georgia Dunston, Charles N Rotimi
Genome wide association studies (GWAS) for type 2 diabetes (T2D) undertaken in European and Asian ancestry populations have yielded dozens of robustly associated loci. However, the genomics of T2D remains largely understudied in sub-Saharan Africa (SSA), where rates of T2D are increasing dramatically and where the environmental background is quite different than in these previous studies. Here, we evaluate 106 reported T2D GWAS loci in continental Africans. We tested each of these SNPs, and SNPs in linkage disequilibrium (LD) with these index SNPs, for an association with T2D in order to assess transferability and to fine map the loci leveraging the generally reduced LD of African genomes...
2015: Frontiers in Genetics
https://www.readbyqxmd.com/read/26507551/genome-wide-association-study-identifies-african-ancestry-specific-variants-for-metabolic-syndrome
#10
Fasil Tekola-Ayele, Ayo P Doumatey, Daniel Shriner, Amy R Bentley, Guanjie Chen, Jie Zhou, Olufemi Fasanmade, Thomas Johnson, Johnnie Oli, Godfrey Okafor, Benjami A Eghan, Kofi Agyenim-Boateng, Clement Adebamowo, Albert Amoah, Joseph Acheampong, Adebowale Adeyemo, Charles N Rotimi
The metabolic syndrome (MetS) is a constellation of metabolic disorders that increase the risk of developing several diseases including type 2 diabetes and cardiovascular diseases. Although genome-wide association studies (GWAS) have successfully identified variants associated with individual traits comprising MetS, the genetic basis and pathophysiological mechanisms underlying the clustering of these traits remain unclear. We conducted GWAS of MetS in 1427 Africans from Ghana and Nigeria followed by replication testing and meta-analysis in another continental African sample from Kenya...
December 2015: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/25587486/evidence-of-insulin-resistance-in-adult-uncomplicated-malaria-result-of-a-two-year-prospective-study
#11
Samuel Acquah, Johnson Nyarko Boampong, Benjamin Ackon Eghan Jnr, Magdalena Eriksson
The study aimed at investigating the effects of adult uncomplicated malaria on insulin resistance. Fasting levels of blood glucose (FBG), glycosylated hemoglobin (HbA1c), and serum insulin were measured in 100 diabetics and 100 age-matched controls before and during Plasmodium falciparum malaria. Insulin resistance and beta cell function were computed by homeostatic models assessment of insulin resistance (HOMAIR) and beta cell function (HOMAB) formulae, respectively. Body mass index (BMI) was computed. At baseline, diabetics had significantly (P < 0...
2014: Malaria Research and Treatment
https://www.readbyqxmd.com/read/23943901/cost-concerns-of-patients-with-cancer
#12
Tammy K Stump, Naa Eghan, Brian L Egleston, Olivia Hamilton, Melanie Pirollo, J Sanford Schwartz, Katrina Armstrong, J Robert Beck, Neal J Meropol, Yu-Ning Wong
PURPOSE: Health care providers are accustomed to identifying populations for whom cost-related concerns may be a significant barrier, such as the poor, but few empiric data have been collected to substantiate such assumptions, particularly among insured patients. METHODS: Patients with cancer from academic and community hospitals completed a questionnaire that included closed-ended items concerning demographic variables, optimism, numeracy, and concerns about present and future medical costs...
September 2013: Journal of Oncology Practice
https://www.readbyqxmd.com/read/23872905/cancer-patients-trade-offs-among-efficacy-toxicity-and-out-of-pocket-cost-in-the-curative-and-noncurative-setting
#13
Yu-Ning Wong, Brian L Egleston, Kush Sachdeva, Naa Eghan, Melanie Pirollo, Tammy K Stump, John Robert Beck, Katrina Armstrong, Jerome Sanford Schwartz, Neal J Meropol
BACKGROUND: When making treatment decisions, cancer patients must make trade-offs among efficacy, toxicity, and cost. However, little is known about what patient characteristics may influence these trade-offs. METHODS: A total of 400 cancer patients reviewed 2 of 3 stylized curative and noncurative scenarios that asked them to choose between 2 treatments of varying levels of efficacy, toxicity, and cost. Each scenario included 9 choice sets. Demographics, cost concerns, numeracy, and optimism were assessed...
September 2013: Medical Care
https://www.readbyqxmd.com/read/22973513/variation-in-apol1-contributes-to-ancestry-level-differences-in-hdlc-kidney-function-association
#14
Amy Rebecca Bentley, Ayo P Doumatey, Guanjie Chen, Hanxia Huang, Jie Zhou, Daniel Shriner, Congqing Jiang, Zhenjian Zhang, Guozheng Liu, Olufemi Fasanmade, Thomas Johnson, Johnnie Oli, Godfrey Okafor, Benjamin A Eghan, Kofi Agyenim-Boateng, Jokotade Adeleye, Williams Balogun, Clement Adebamowo, Albert Amoah, Joseph Acheampong, Adebowale Adeyemo, Charles N Rotimi
Low levels of high-density cholesterol (HDLc) accompany chronic kidney disease, but the association between HDLc and the estimated glomerular filtration rate (eGFR) in the general population is unclear. We investigated the HDLc-eGFR association in nondiabetic Han Chinese (HC, n = 1100), West Africans (WA, n = 1497), and African Americans (AA, n = 1539). There were significant differences by ancestry: HDLc was positively associated with eGFR in HC (β = 0.13, P < 0.0001), but negatively associated among African ancestry populations (WA: -0...
2012: International Journal of Nephrology
https://www.readbyqxmd.com/read/22957255/circulating-adiponectin-is-associated-with-renal-function-independent-of-age-and-serum-lipids-in-west-africans
#15
A P Doumatey, J Zhou, H Huang, J Adeleye, W Balogun, O Fasanmade, T Johnson, J Oli, G Okafor, A Amoah, B Eghan, K Agyenim-Boateng, J Acheampong, C Adebamowo, A Adeyemo, C N Rotimi
Adiponectin, a protein secreted by adipose tissue, has been associated with renal dysfunction. However, these observations have not been adequately investigated in large epidemiological studies of healthy individuals in general and in African populations in particular. Hence, we designed this study to evaluate the relationship between adiponectin and renal function in a large group of nondiabetic West Africans. Total adiponectin was measured in 792 participants. MDRD and Cockroft-Gault (CG-) estimated GFR were used as indices of renal function...
2012: International Journal of Nephrology
https://www.readbyqxmd.com/read/22519123/violet-diode-laser-induced-chlorophyll-fluorescence-a-tool-for-assessing-mosaic-disease-severity-in-cassava-manihot-esculenta-crantz-cultivars
#16
Benjamin Anderson, Moses J Eghan, Elvis Asare-Bediako, Paul K Buah-Bassuah
Violet diode laser-induced chlorophyll fluorescence was used in agronomical assessment (disease severity and average yield per plant). Because cassava (Manihot esculenta Crantz) is of economic importance, improved cultivars with various levels of affinity for cassava mosaic disease were investigated. Fluorescence data correlated with cassava mosaic disease severity levels and with the average yield per plant.
January 2012: Environmental Technology
https://www.readbyqxmd.com/read/22492993/c-reactive-protein-crp-promoter-polymorphisms-influence-circulating-crp-levels-in-a-genome-wide-association-study-of-african-americans
#17
Ayo P Doumatey, Guanjie Chen, Fasil Tekola Ayele, Jie Zhou, Michael Erdos, Daniel Shriner, Hanxia Huang, Jokotade Adeleye, Williams Balogun, Olufemi Fasanmade, Thomas Johnson, Johnnie Oli, Godfrey Okafor, Albert Amoah, Benjamin A Eghan, Kofi Agyenim-Boateng, Joseph Acheampong, Clement Adebamowo, Norman P Gerry, Michael F Christman, Adebowale Adeyemo, Charles N Rotimi
C-reactive protein (CRP) is an acute phase reactant protein produced primarily by the liver. Circulating CRP levels are influenced by genetic and non-genetic factors, including infection and obesity. Genome-wide association studies (GWAS) provide an unbiased approach towards identifying loci influencing CRP levels. None of the six GWAS for CRP levels has been conducted in an African ancestry population. The present study aims to: (i) identify genetic variants that influence serum CRP in African Americans (AA) using a genome-wide association approach and replicate these findings in West Africans (WA), (ii) assess transferability of major signals for CRP reported in European ancestry populations (EA) to AA and (iii) use the weak linkage disequilibrium (LD) structure characteristic of African ancestry populations to fine-map the previously reported CRP locus...
July 1, 2012: Human Molecular Genetics
https://www.readbyqxmd.com/read/22205395/genome-wide-associated-loci-influencing-interleukin-il-10-il-1ra-and-il-6-levels-in-african-americans
#18
Fasil Tekola Ayele, Ayo Doumatey, Hanxia Huang, Jie Zhou, Bashira Charles, Michael Erdos, Jokotade Adeleye, Williams Balogun, Olufemi Fasanmade, Thomas Johnson, Johnnie Oli, Godfrey Okafor, Albert Amoah, Benjamin A Eghan, Kofi Agyenim-Boateng, Joseph Acheampong, Clement A Adebamowo, Alan Herbert, Norman Gerry, Michael Christman, Guanjie Chen, Daniel Shriner, Adebowale Adeyemo, Charles N Rotimi
Interleukins (ILs) are key mediators of the immune response and inflammatory process. Plasma levels of IL-10, IL-1Ra, and IL-6 are associated with metabolic conditions, show large inter-individual variations, and are under strong genetic control. Therefore, elucidation of the genetic variants that influence levels of these ILs provides useful insights into mechanisms of immune response and pathogenesis of diseases. We conducted a genome-wide association study (GWAS) of IL-10, IL-1Ra, and IL-6 levels in 707 non-diabetic African Americans using 5,396,780 imputed and directly genotyped single nucleotide polymorphisms (SNPs) with adjustment for gender, age, and body mass index...
May 2012: Immunogenetics
https://www.readbyqxmd.com/read/20434165/transcranial-doppler-ultrasonography-and-prophylactic-transfusion-program-is-effective-in-preventing-overt-stroke-in-children-with-sickle-cell-disease
#19
COMPARATIVE STUDY
Henrietta Enninful-Eghan, Reneé H Moore, Rebecca Ichord, Kim Smith-Whitley, Janet L Kwiatkowski
OBJECTIVE: To assess the impact of our transcranial Doppler ultrasonography (TCD) program on the incidence of first stroke and the rate of transfusion for stroke prevention in children with sickle cell disease. STUDY DESIGN: In this single-institution, retrospective study, we compared the incidence of stroke and of transfusion for stroke prevention in 475 patients observed in the 8-year period before instituting TCD screening with the rate in 530 children in the 8-year period after...
September 2010: Journal of Pediatrics
https://www.readbyqxmd.com/read/20229387/use-of-isotopes-to-study-floodplain-wetland-and-river-flow-interaction-in-the-white-volta-river-basin-ghana
#20
Benjamin Kofi Nyarko, David Kofi Essumang, Moses J Eghan, Barbara Reichert, Nick van de Giesen, Paul Vlek
Floodplain wetlands influence the timing and magnitude of stream responses to rainfall. In managing and sustaining the level of water resource usage in any river catchment as well as when modelling hydrological processes, it is essential that the role of floodplain wetlands in stream flows is recognised and understood. Existing studies on hydrology within the Volta River basin have not adequately represented the variability of wetland hydrological processes and their contribution to the sustenance of river flow...
March 2010: Isotopes in Environmental and Health Studies
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