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https://www.readbyqxmd.com/read/28621259/clinical-effectiveness-and-cost-effectiveness-of-a-multifaceted-podiatry-intervention-for-falls-prevention-in-older-people-a-multicentre-cohort-randomised-controlled-trial-the-reducing-falls-with-orthoses-and-a-multifaceted-podiatry-intervention-trial
#1
Sarah Cockayne, Sara Rodgers, Lorraine Green, Caroline Fairhurst, Joy Adamson, Arabella Scantlebury, Belen Corbacho, Catherine E Hewitt, Kate Hicks, Robin Hull, Anne-Maree Keenan, Sarah E Lamb, Caroline McIntosh, Hylton B Menz, Anthony Redmond, Zoe Richardson, Wesley Vernon, Judith Watson, David J Torgerson
BACKGROUND: Falls are a serious cause of morbidity and cost to individuals and society. Evidence suggests that foot problems and inappropriate footwear may increase the risk of falling. Podiatric interventions could help reduce falls; however, there is limited evidence regarding their clinical effectiveness and cost-effectiveness. OBJECTIVES: To determine the clinical effectiveness and cost-effectiveness of a multifaceted podiatry intervention for preventing falls in community-dwelling older people at risk of falling, relative to usual care...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28590876/cucumber-green-mottle-mosaic-virus-rapidly-increasing-global-distribution-etiology-epidemiology-and-management
#2
Aviv Dombrovsky, Lucy T T Tran-Nguyen, Roger A C Jones
Cucumber green mottle mosaic virus (CGMMV) was first described in 1935 infecting cucumber, making it one of the first plant viruses to be described. Its initial distribution occurred out of England to other countries. This was followed by its subsequent distribution from England and these other countries. This process increased slowly between 1935 and 1985, faster between 1986 and 2006, and rapidly between 2007 and 2016. The discovery that it diminished cucurbit fruit yields and quality, especially of watermelon, prompted a substantial research effort in worst-affected countries...
June 7, 2017: Annual Review of Phytopathology
https://www.readbyqxmd.com/read/28584297/increased-risk-of-influenza-among-vaccinated-adults-who-are-obese
#3
S D Neidich, W D Green, J Rebeles, E A Karlsson, S Schultz-Cherry, T L Noah, S Chakladar, M G Hudgens, S S Weir, M A Beck
BACKGROUND: Influenza infects 5-15% of the global population each year, and obesity has been shown to be an independent risk factor for increased influenza-related complications including hospitalization and death. However, the risk of developing influenza or ILI in a vaccinated obese adult population has not been addressed. OBJECTIVE: This study evaluated whether obesity was associated with increased risk of influenza and influenza-like illness among vaccinated adults...
June 6, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28537576/an-infant-and-mother-with-severe-b12-deficiency-vitamin-b12-status-assessment-should-be-determined-in-pregnant-women-with-anaemia
#4
A Sobczyńska-Malefora, R Ramachandran, D Cregeen, E Green, P Bennett, D J Harrington, H A Lemonde
The vitamin B12 status of infants depends on maternal B12 status during pregnancy, and during lactation if breastfed. We present a 9-month-old girl who was admitted to the metabolic unit for assessment of developmental delay. She was exclusively breastfed and the introduction of solids at 5 months was unsuccessful. Investigations revealed pancytopenia, undetectable B12 and highly elevated methylmalonic acid and homocysteine. Methylmalonic acid and homocysteine normalised following B12 injections. Marked catch-up of developmental milestones was noted after treatment with B12...
May 24, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28524871/in-situ-light-responses-of-the-proteorhodopsin-bearing-antarctic-sea-ice-bacterium-psychroflexus-torques
#5
David J Burr, Andrew Martin, Elizabeth W Maas, Ken G Ryan
Proteorhodopsin (PR) is a wide-spread protein found in many marine prokaryotes. PR allows for the potential conversion of solar energy to ATP, possibly assisting in cellular growth and survival during periods of high environmental stress. PR utilises either blue or green light through a single amino acid substitution. We incubated the PR-bearing bacterium Psychroflexus torquis 50 cm deep within Antarctic sea ice for 13 days, exposing cultures to diurnal fluctuations in light and temperature. Enhanced growth occurred most prominently in cultures incubated under irradiance levels of ∼50 μmol photons m(-2) s(-1), suggesting PR provides a strong selective advantage...
May 19, 2017: ISME Journal
https://www.readbyqxmd.com/read/28496007/association-between-tea-consumption-and-risk-of-cognitive-disorders-a-dose-response-meta-analysis-of-observational-studies
#6
Xueying Liu, Xiaoyuan Du, Guanying Han, Wenyuan Gao
BACKGROUND: The epidemiological evidence for a dose-response relationship between tea consumption and risk of cognitive disorders is sparse. The aim of the study was to summarize the evidence for the association of tea consumption with risk of cognitive disorders and assess the dose-response relationship. METHODS: We searched electronic databases of Pubmed, Embase, and Cochrane Library (from 1965 to Jan 19, 2017) for eligible studies that published in the international journals...
April 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28476386/a-5-year-review-of-clinical-outcome-measures-published-in-the-journal-of-the-american-podiatric-medical-association-and-the-journal-of-foot-and-ankle-surgery%C3%A2
#7
Todd Hasenstein, Timothy Greene, Andrew J Meyr
This investigation presents a review of all of the clinical outcome measures used by authors and published in the Journal of the American Podiatric Medical Association and the Journal of Foot and Ankle Surgery(®) from January 1, 2011, to December 31, 2015. Of 1,336 articles published during this time frame, 655 (49.0%) were classified as original research and included in this analysis. Of these 655 articles, 151 (23.1%) included at least one clinical outcome measure. Thirty-seven unique clinical outcome scales were used by authors and published during this period...
May 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28473085/acr-appropriateness-criteria-%C3%A2-stage-i-breast-cancer-initial-workup-and-surveillance-for-local-recurrence-and-distant-metastases-in-asymptomatic-women
#8
Linda Moy, Lisa Bailey, Carl D'Orsi, Edward D Green, Anna I Holbrook, Su-Ju Lee, Ana P Lourenco, Martha B Mainiero, Karla A Sepulveda, Priscilla J Slanetz, Sunita Trikha, Monica M Yepes, Mary S Newell
Women and health care professionals generally prefer intensive follow-up after a diagnosis of breast cancer. However, there are no survival differences between women who obtain intensive surveillance with imaging and laboratory studies compared with women who only undergo testing because of the development of symptoms or findings on clinical examinations. American Society of Clinical Oncology and National Comprehensive Cancer Network guidelines state that annual mammography is the only imaging examination that should be performed to detect a localized breast recurrence in asymptomatic patients; more imaging may be needed if the patient has locoregional symptoms (eg, palpable abnormality)...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28473081/acr-appropriateness-criteria-%C3%A2-breast%C3%A2-pain
#9
Peter M Jokich, Lisa Bailey, Carl D'Orsi, Edward D Green, Anna I Holbrook, Su-Ju Lee, Ana P Lourenco, Martha B Mainiero, Linda Moy, Karla A Sepulveda, Priscilla J Slanetz, Sunita Trikha, Monica M Yepes, Mary S Newell
Breast pain (or tenderness) is a common symptom, experienced by up to 80% of women at some point in their lives. Fortunately, it is rarely associated with breast cancer. However, breast pain remains a common cause of referral for diagnostic breast imaging evaluation. Appropriate workup depends on the nature and focality of the pain, as well as the age of the patient. Imaging evaluation is usually not indicated if the pain is cyclic or nonfocal. For focal, noncyclic pain, imaging may be appropriate, mainly for reassurance and to identify treatable causes...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28473077/acr-appropriateness-criteria-%C3%A2-palpable-breast%C3%A2-masses
#10
Linda Moy, Samantha L Heller, Lisa Bailey, Carl D'Orsi, Roberta M DiFlorio, Edward D Green, Anna I Holbrook, Su-Ju Lee, Ana P Lourenco, Martha B Mainiero, Karla A Sepulveda, Priscilla J Slanetz, Sunita Trikha, Monica M Yepes, Mary S Newell
Breast cancer is the most common female malignancy and the second leading cause of female cancer death in the United States. Although the majority of palpable breast lumps are benign, a new palpable breast mass is a common presenting sign of breast cancer. Any woman presenting with a palpable lesion should have a thorough clinical breast examination, but because many breast masses may not exhibit distinctive physical findings, imaging evaluation is necessary in almost all cases to characterize the palpable lesion...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28473070/acr-appropriateness-criteria-%C3%A2-evaluation-of-nipple-discharge
#11
Su-Ju Lee, Sunita Trikha, Linda Moy, Paul Baron, Roberta M diFlorio, Edward D Green, Samantha L Heller, Anna I Holbrook, Alana A Lewin, Ana P Lourenco, Bethany L Niell, Priscilla J Slanetz, Ashley R Stuckey, Nina S Vincoff, Susan P Weinstein, Monica M Yepes, Mary S Newell
Appropriate imaging evaluation of nipple discharge depends the nature of the discharge. Imaging is not indicated for women with physiologic nipple discharge. For evaluation of pathologic nipple discharge, multiple breast imaging modalities are rated for evidence-based appropriateness under various scenarios. For women age 40 or older, mammography or digital breast tomosynthesis (DBT) should be the initial examination. Ultrasound is usually added as a complementary examination, with some exceptions. For women age 30 to 39, either mammogram or ultrasound may be used as the initial examination on the basis of institutional preference...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28463959/pre-diagnosis-diet-and-survival-after-a-diagnosis-of-ovarian-cancer
#12
Mary C Playdon, Christina M Nagle, Torukiri I Ibiebele, Leah M Ferrucci, Melinda M Protani, Jonathan Carter, Simon E Hyde, Deborah Neesham, James L Nicklin, Susan T Mayne, Penelope M Webb
BACKGROUND: The relationship between diet and survival after ovarian cancer diagnosis is unclear as a result of a limited number of studies and inconsistent findings. METHODS: We examined the association between pre-diagnostic diet and overall survival in a population-based cohort (n=811) of Australian women diagnosed with invasive epithelial ovarian cancer between 2002 and 2005. Diet was measured by validated food frequency questionnaire. Deaths were ascertained up to 31 August 2014 via medical record review and Australian National Death Index linkage...
June 6, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28463018/a-5-year-review-of-clinical-outcome-measures-published-in-the-journal-of-the-american-podiatric-medical-association-and-the-journal-of-foot-and-ankle-surgery%C3%A2
#13
Andrew J Meyr, Todd Hasenstein, Timothy Greene
BACKGROUND: This investigation presents a review of all clinical outcome measures utilized by authors and published in the Journal of the American Podiatric Medical Association and The Journal of Foot and Ankle Surgery® from 01-2011 to 12-2015. METHODS: There were 1336 articles published over this time frame, 655 (49.03%) of which were classified as original research and included in this analysis. RESULTS: Of these 655, 151 (23.05%) included at least one clinical outcome measure...
May 2, 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28440211/a-cluster-randomised-trial-cost-effectiveness-analysis-and-psychosocial-evaluation-of-insulin-pump-therapy-compared-with-multiple-injections-during-flexible-intensive-insulin-therapy-for-type-1-diabetes-the-repose-trial
#14
Simon Heller, David White, Ellen Lee, Julia Lawton, Daniel Pollard, Norman Waugh, Stephanie Amiel, Katharine Barnard, Anita Beckwith, Alan Brennan, Michael Campbell, Cindy Cooper, Munyaradzi Dimairo, Simon Dixon, Jackie Elliott, Mark Evans, Fiona Green, Gemma Hackney, Peter Hammond, Nina Hallowell, Alan Jaap, Brian Kennon, Jackie Kirkham, Robert Lindsay, Peter Mansell, Diana Papaioannou, David Rankin, Pamela Royle, W Henry Smithson, Carolin Taylor
BACKGROUND: Insulin is generally administered to people with type 1 diabetes mellitus (T1DM) using multiple daily injections (MDIs), but can also be delivered using infusion pumps. In the UK, pumps are recommended for patients with the greatest need and adult use is less than in comparable countries. Previous trials have been small, of short duration and have failed to control for training in insulin adjustment. OBJECTIVE: To assess the clinical effectiveness and cost-effectiveness of pump therapy compared with MDI for adults with T1DM, with both groups receiving equivalent structured training in flexible insulin therapy...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28398349/allelopathic-interactions-of-linoleic-acid-and-nitric-oxide-increase-the-competitive-ability-of-microcystis-aeruginosa
#15
Hao Song, Michel Lavoie, Xiaoji Fan, Hana Tan, Guangfu Liu, Pengfei Xu, Zhengwei Fu, Hans W Paerl, Haifeng Qian
The frequency and intensity of cyanobacterial blooms are increasing worldwide with major societal and economic costs. Interactions between toxic cyanobacteria and eukaryotic algal competitors can affect toxic bloom formation, but the exact mechanisms of interspecies interactions remain unknown. Using metabolomic and proteomic profiling of co-cultures of the toxic cyanobacterium Microcystis aeruginosa with a green alga as well as of microorganisms collected in a Microcystis spp. bloom in Lake Taihu (China), we disentangle novel interspecies allelopathic interactions...
April 11, 2017: ISME Journal
https://www.readbyqxmd.com/read/28341331/how-sonochemistry-contributes-to-green-chemistry
#16
Gregory Chatel
Based on the analyses of papers from the literature, and especially those published in Ultrasonics Sonochemistry journal, the contribution of sonochemistry to green chemistry area has been discussed here. Important reminders and insights on the good practices and considerations have been made to understand and demonstrate how sonochemistry can continue to efficiently contribute to green chemistry area in the further studies.
March 15, 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28301742/microbial-rhodopsins-diversity-mechanisms-and-optogenetic-applications
#17
Elena G Govorunova, Oleg A Sineshchekov, Hai Li, John L Spudich
Microbial rhodopsins are a family of photoactive retinylidene proteins widespread throughout the microbial world. They are notable for their diversity of function, using variations of a shared seven-transmembrane helix design and similar photochemical reactions to carry out distinctly different light-driven energy and sensory transduction processes. Their study has contributed to our understanding of how evolution modifies protein scaffolds to create new protein chemistry, and their use as tools to control membrane potential with light is fundamental to optogenetics for research and clinical applications...
March 9, 2017: Annual Review of Biochemistry
https://www.readbyqxmd.com/read/28277369/green-journal-update-revitalize-definitions-and-introducing-a-more-responsive-website
#18
John R Fischer, Nancy C Chescheir
No abstract text is available yet for this article.
April 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28275244/mosaic-chromosome-y-loss-and-testicular-germ-cell-tumor-risk
#19
Mitchell J Machiela, Casey L Dagnall, Anand Pathak, Jennifer T Loud, Stephen J Chanock, Mark H Greene, Katherine A McGlynn, Douglas R Stewart
Studies have suggested mosaic loss of chromosome Y (mLOY) in blood-derived DNA is common in older men. Cohort studies investigating mLOY and mortality have reported contradictory results. Previous work found that a 1.6 Mb deletion of the AZFc region on the Y chromosome (the 'gr/gr' deletion) is associated with both male infertility and increased risk of testicular germ cell tumors (TGCT). We investigated whether mosaic loss across the entire Y chromosome was associated with TGCT. We obtained blood- and buccal-derived DNA from two case-control studies: the NCI Familial Testicular Cancer Study (cases=172; controls=163) and the NCI US Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study (cases=506; controls=611)...
June 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28246141/vasopressor-use-following-traumatic-injury-protocol-for-a-systematic-review
#20
Mathieu Hylands, Augustin Toma, Nicolas Beaudoin, Anne-Julie Frenette, Frederick D'Aragon, Emilie Belley-Côté, Morten Hylander, François Lauzier, Reed Alexander Siemieniuk, Emmanuel Charbonney, Joey Kwong, Jon Henrik Laake, Gordon Guyatt, Per Olav Vandvik, Bram Rochwerg, Robert Green, Ian Ball, Damon Scales, Srinivas Murthy, Sandro Rizoli, Pierre Asfar, François Lamontagne
INTRODUCTION: Worldwide, traumatic casualties are projected to exceed 8 million by year 2020. Haemorrhagic shock and brain injury are the leading causes of death following trauma. While intravenous fluids have traditionally been used to support organ perfusion in the setting of haemorrhage, recent investigations have suggested that restricting fluid therapy by tolerating more severe hypotension may improve survival. However, the safety of permissive hypotension remains uncertain, particularly among patients who have suffered a traumatic brain injury...
February 28, 2017: BMJ Open
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