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https://www.readbyqxmd.com/read/29140069/dual-functions-of-cyclometalated-iridium-iii-complexes-anti-metastasis-and-lysosome-damaged-photodynamic-therapy
#1
Fang-Xin Wang, Mu-He Chen, Yan-Nan Lin, Hang Zhang, Cai-Ping Tan, Liang-Nian Ji, Zongwan Mao
Four phosphorescent cyclometalated iridium(III) complexes containing benzimidazole moiety have been designed and synthesized. These Ir(III) complexes can inhibit several cancerous processes including cell migration, invasion, colony formation and angiogenesis effectively. Interestingly, they show much higher singlet oxygen quantum yield in acidic solution than in neutral solution. Upon irradiation at 425 nm with low energy (1.2 J·cm(-2)), they can induce apoptosis through lysosomal damage, evaluation of ROS level and activation of caspase-3/7...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29136507/organelle-specific-o-glycosylation-drives-mmp14-activation-tumor-growth-and-metastasis
#2
Anh Tuan Nguyen, Joanne Chia, Manon Ros, Kam Man Hui, Frederic Saltel, Frederic Bard
Cancers grow within tissues through molecular mechanisms still unclear. Invasiveness correlates with perturbed O-glycosylation, a covalent modification of cell-surface proteins. Here, we show that, in human and mouse liver cancers, initiation of O-glycosylation by the GALNT glycosyl-transferases increases and shifts from the Golgi to the endoplasmic reticulum (ER). In a mouse liver cancer model, expressing an ER-targeted GALNT1 (ER-G1) massively increased tumor expansion, with median survival reduced from 23 to 10 weeks...
November 13, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29133897/wbscr22-confers-oxaliplatin-resistance-in-human-colorectal-cancer
#3
Dongmei Yan, Linglan Tu, Haining Yuan, Jianfei Fang, Liyan Cheng, Xiaoliang Zheng, Xiaoju Wang
Human WBSCR22 gene is involved in tumor metastasis, cell growth and invasion, however, its role in chemosensitivity to antitumor agents remains unknown. In this study, we analyzed the TCGA cohort and found the expression of WBSCR22 was significantly elevated in human colorectal cancer (CRC) tissue. WBSCR22 could be served as an independent risk predictor for overall survival (OS), and up-regulated WBSCR22 could predict unfavorable OS for CRC patients. Knockdown of WBSCR22 significantly sensitized CRC cells to oxaliplatin in vitro and in vivo, while overexpression of WBSCR22 led to cellular resistance to oxaliplatin treatment...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133040/synthesis-and-biological-evaluation-of-novel-alkylated-polyamine-analogues-as-potential-anticancer-agents
#4
Meng Li, Yuxia Wang, Chaochao Ge, Liping Chang, Chaojie Wang, Zhiyong Tian, Senzhen Wang, Fujun Dai, Luyao Zhao, Songqiang Xie
A new class of polyamine analogues modified by alkylation at the terminal of the polyamine chain has been synthesized and their structures were determined by (1)H NMR, (13)C NMR, ESI-MS and elemental analysis. As the representative compound, 3f displayed a broad spectrum of anti-cancer effects by MTT assays. Tumor xenograft model and pulmonary metastasis model showed that compound 3f significantly suppressed tumor growth and metastasis in vivo, which was more stronger than the reference drug amonafide. Molecular mechanisms indicated that compound 3f exhibited antiproliferative activities and induced the generation of reactive oxygen species (ROS), which resulted in the occurrence of autophagy...
November 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29123322/hypoxia-induced-reactive-oxygen-species-mediate-n-cadherin-and-serpine1-expression-egfr-signalling-and-motility-in-mda-mb-468-breast-cancer-cells
#5
Iman Azimi, Rosalie M Petersen, Erik W Thompson, Sarah J Roberts-Thomson, Gregory R Monteith
One of the hallmarks of the tumour microenvironment is hypoxia resulting from increased oxygen consumption by proliferative cancer cells and altered vasculature. Hypoxic tension initiates various cellular signals and can drive epithelial to mesenchymal transition (EMT), a process important in cancer progression. In this study, using the antioxidant N-acetylcysteine (NAC), we show that hypoxia-induced reactive oxygen species (ROS) in MDA-MB-468 breast cancer cells, selectively regulate hypoxia-induced increases in N-cadherin and SERPINE1, two proteins involved in cell adhesion...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29121049/haplotype-cgc-from-xpd-hogg1-and-itga2-polymorphisms-increases-the-risk-of-nasopharyngeal-carcinoma-in-malaysia
#6
Eng-Zhuan Ban, Munn-Sann Lye, Pei Pei Chong, Yoke-Yeow Yap, Siew Ying Crystale Lim, Hejar Abdul Rahman
BACKGROUND: 8-oxoG, a common DNA lesion resulting from reactive oxygen species (ROS), has been shown to be associated with cancer initiation. hOGG1 DNA glycosylase is the primary enzyme responsible for excision of 8-oxoG through base excision repair (BER). Integrins are members of a family of cell surface receptors that mediate the cell-cell and extracellular matrix (ECM) interactions. Integrins are involved in almost every aspect of carcinogenesis, from cell differentiation, cell proliferation, metastasis to angiogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/29113449/where-hematopoietic-stem-cells-live-the-bone-marrow-niche
#7
Krzysztof Tomasz Szade, Gunsagar Singh Gulati, Charles K F Chan, Kevin S Kao, Masanori Miyanishi, Kristopher Marjon, Rahul Sinha, Benson George, James Y Chen, Irving Weissman
Hematopoietic stem cells (HSCs) can sustain the production of blood throughout one's lifetime. However, for proper self-renewal of its own population and differentiation to blood, the HSC requires a specialized microenvironment called the "niche". Recent Advances: Recent studies using novel mouse models have shed new light on the cellular architecture and function of the HSC niche. Here, we review the different cells that constitute the HSC niche and the molecular mechanisms that underlie HSC and niche interaction...
November 7, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29098529/18%C3%AE-glycyrrhetinic-acid-inhibits-migration-and-invasion-of-human-gastric-cancer-cells-via-the-ros-pkc-%C3%AE-erk-pathway
#8
Hongke Cai, Xi Chen, Jianbo Zhang, Jijian Wang
18β-glycyrrhetinic acid (18β-GA) is a bioactive component of licorice root which exerts pharmacological activities including anti-inflammatory, antiviral, anti-oxidative and anti-cancer effects. The current study further investigated the molecular mechanisms associated with the inhibitory effects of 18β-GA on tumor metastasis in human gastric cancer cells. The results indicated that 18β-GA significantly reduced invasion and migration activities and suppressed MMP-2 and 9 activities on SGC-7901cells in a dose-dependent manner...
November 2, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29081061/zoledronic-acid-bevacizumab-and-dexamethasone-induced-apoptosis-mitochondrial-oxidative-stress-and-calcium-signaling-are-decreased-in-human-osteoblast-like-cell-line-by-selenium-treatment
#9
Tayfun Yazıcı, Gülperi Koçer, Mustafa Nazıroğlu, İshak Suat Övey, Ahmi Öz
Increased intracellular free calcium ion (Ca(2+)) concentration induces excessive oxidative stress and apoptosis. Medical procedures such as zoledronic acid (Zol), bevacizumab (Bev), and dexamethasone (Dex) are usually used in the treatment of bone diseases (osteoporosis, Paget's disease, etc.) and to prevent metastasis in the bone although the procedures induce osteonecrosis of the jaw through excessive production of reactive oxygen species (ROS). Recently, we observed regulator roles of selenium (Se) on apoptosis and Ca(2+) entry through transient receptor potential vanilloid 1 (TRPV1) channels in the cancer cell lines...
October 28, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29080556/a-new-mutation-independent-approach-to-cancer-therapy-inhibiting-oncogenic-ras-and-myc-by-targeting-mitochondrial-biogenesis
#10
Bela Ozsvari, Federica Sotgia, Michael P Lisanti
Here, we used MCF7 cells as a model system to interrogate how MYC/RAS co-operativity contributes to metabolic flux and stemness in breast cancer cells. We compared the behavior of isogenic MCF7 cell lines transduced with c-Myc or H-Ras (G12V), either individually or in combination. Cancer stem cell (CSC) activity was measured using the mammosphere assay. c-Myc augmented both mammosphere formation and mitochondrial respiration, without any effects on glycolytic flux. In contrast, H-Ras (G12V) synergistically augmented both mammosphere formation and glycolysis, but only in combination with c-Myc, directly demonstrating MYC/RAS co-operativity...
October 27, 2017: Aging
https://www.readbyqxmd.com/read/29059164/fam49b-a-novel-regulator-of-mitochondrial-function-and-integrity-that-suppresses-tumor-metastasis
#11
M S Chattaragada, C Riganti, M Sassoe, M Principe, M M Santamorena, C Roux, C Curcio, A Evangelista, P Allavena, R Salvia, B Rusev, A Scarpa, P Cappello, F Novelli
Mitochondrial dysregulation plays a central role in cancers and drives reactive oxygen species (ROS)-dependent tumor progression. We investigated the pro-tumoral roles of mitochondrial dynamics and altered intracellular ROS levels in pancreatic ductal adenocarcinoma (PDAC). We identified 'family with sequence similarity 49 member B' (FAM49B) as a mitochondria-localized protein that regulates mitochondrial fission and cancer progression. Silencing FAM49B in PDAC cells resulted in increased fission and mitochondrial ROS generation, which enhanced PDAC cell proliferation and invasion...
October 23, 2017: Oncogene
https://www.readbyqxmd.com/read/29054798/the-antimicrobial-peptide-nisin-z-induces-selective-toxicity-and-apoptotic-cell-death-in-cultured-melanoma-cells
#12
Angélique Lewies, Johannes Frederik Wentzel, Hayley van Dyk, Lissinda Hester Du Plessis
Reprogramming of cellular metabolism is now considered one of the hallmarks of cancer. Most malignant cells Reprogramming of cellular metabolism is now considered one of the hallmarks of cancer. Most malignant cells present with altered energy metabolism which is associated with elevated reactive oxygen species (ROS) generation. This is also evident for melanoma, the leading cause of skin cancer related deaths. Altered mechanisms affecting mitochondrial bioenergetics pose attractive targets for novel anti-cancer therapies...
October 17, 2017: Biochimie
https://www.readbyqxmd.com/read/29039459/bc-02-eradicates-liver-cancer-stem-cells-by-upregulating-the-ros-dependent-dna-damage
#13
Chunhui Dou, Chunyan Fang, Yan Zhao, Xiaoyan Fu, Yufei Zhang, Dongqi Zhu, Huina Wu, Huijie Liu, Jian Zhang, Wenfang Xu, Zhijun Liu, Hongyan Wang, Daqi Li, Xuejian Wang
Cancer stem cells (CSCs) are responsible for chemoresistance, tumor recurrence and metastasis. Reportedly, aminopeptidase N (APN, also known as CD13) is a marker for semi-quiescent CSCs and a therapeutic target in human liver CSCs. In the present study, the effect of BC-02, a compound obtained by conjugating a CD13 inhibitor bestatin and fluorouracil (5-FU), was investigated toward liver CSCs. Tumor spheres formed in serum-free culture conditions have been successfully used to enrich CSCs. In this study, the sphere cells were shown to have several characteristics of CSCs, including drug resistance, high tumorigenicity, epithelial-mesenchymal transition (EMT) phenotype, lower reactive oxygen species (ROS) levels, greater colony-forming efficiency and increased proliferation capacity in vitro...
October 16, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29026308/role-of-poly-%C3%AE%C2%B5-caprolactone-lipid-core-nanocapsules-on-melanoma-neutrophil-crosstalk
#14
Carine C Drewes, Aline de Cs Alves, Cristina B Hebeda, Isabela Copetti, Silvana Sandri, Mayara K Uchiyama, Koiti Araki, Silvia S Guterres, Adriana R Pohlmann, Sandra H Farsky
Metastatic melanoma is an aggressive cancer with increasing incidence and limited therapies in advanced stages. Systemic neutrophilia or abundant neutrophils in the tumor contribute toward its worst prognosis, and the interplay of cancer and the immune system has been shown in tumor development and metastasis. We recently showed the in vivo efficacy of poly(ε-caprolactone) lipid-core nanocapsule (LNC) or LNC loaded with acetyleugenol (AcE-LNC) to treat B16F10-induced melanoma in mice. In this study, we investigated whether LNC or AcE-LNC toxicity could involve modifications on crosstalk of melanoma cells and neutrophils...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28990419/proline-metabolism-in-cell-regulation-and-cancer-biology-recent-advances-and-hypotheses
#15
James M Phang
SIGNIFICANCE: It is increasingly clear that proline metabolism plays an important role in metabolic reprogramming, not only in cancer but also in related fields such as aging, senescence, and development. Although first focused on proline catabolism, recent studies from a number of laboratories have emphasized the regulatory effects of proline synthesis and proline cycling. Recent Advances: Although proline dehydrogenase/proline oxidase (PRODH/POX) has been known as a tumor protein 53 (P53)-activated source of redox signaling for initiating apoptosis and autophagy, senescence has been added to the responses...
November 15, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28981199/microrna-661-modulates-redox-and-metabolic-homeostasis-in-colon-cancer
#16
Marta Gómez de Cedrón, Rebeca Acín Pérez, Ruth Sánchez-Martínez, Susana Molina, Jesús Herranz, Jaime Feliu, Guillermo Reglero, Jose Antonio Enríquez, Ana Ramírez de Molina
Cancer cell survival and metastasis are dependent on metabolic reprogramming that is capable of increasing resistance to oxidative and energetic stress. Targeting these two processes can be crucial for cancer progression. Herein, we describe the role of microRNA-661 (miR661) as epigenetic regulator of colon cancer (CC) cell metabolism. miR661 induces a global increase in reactive oxygen species (ROS), specifically in mitochondrial superoxide anions (SO(-) ), which appears to be mediated by decreased carbohydrate metabolism and pentose phosphate pathway, and by a higher dependency on mitochondrial respiration...
October 5, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28971778/strategies-to-tackle-radiation-resistance-by-penetrating-cancer-stem-cell-line-of-scrimmage
#17
So-Yeon Park, Ji-Young Kim, Youngsoo Jun, Jeong-Seok Nam
BACKGROUND: Radiation therapy has become a common therapy for cancer patients and largely improved therapeutic outcomes. However, recurrence after radiation therapy is still a major unsolved concern of cancer patients. The cancer stem cells (CSCs), a small sub-population with capacity of self-renewal and differentiation into diverse types of cancer cells, are considered as strong drivers of metastasis, resistance, and recurrence. OBJECTIVE: We overview the mechanisms behind the radiation resistance of CSCs, and introduce recent patents with the potential to overcome such an obstacle...
October 3, 2017: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/28969555/oxidative-stress-and-cancer-the-role-of-nrf2
#18
Soraya Sajadimajd, Mozafar Khazaei
Oxidative stress due to imbalance between ROS production and detoxification plays the pivotal role in determining cell fate. In response to excessive ROS, apoptotic signaling pathway is activated to promote normal cell death. However, through deregulation of biomolecules, high amount of ROS promotes carcinogenesis in cells with defective signaling factors. In this line, NRF2 appears to be as the master regulator to protect cells from oxidative and electrophilic stress. Nrf2 is an intracellular transcription factor that regulates the expression of a number of genes to encode anti-oxidative enzymes, detoxifying factors, anti-apoptotic proteins and drug transporters...
October 2, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28968982/methylation-of-bnip3-in-pancreatic-cancer-inhibits-the-induction-of-mitochondrial-mediated-tumor-cell-apoptosis
#19
Ye Li, Xu Zhang, Jian Yang, Yi Zhang, Dongming Zhu, Lifeng Zhang, Yanbo Zhu, Dechun Li, Jian Zhou
Bcl-2 interacting protein 3 (BNIP3) is involved in various cellular processes and is considered a key regulator of hypoxia-induced apoptosis. In the present study, the expression of BNIP3 in pancreatic cancer tissues, the correlation with clinicopathological characteristics and prognosis and the regulation of this protein in pancreatic cancer cell lines with regard to the induction of apoptosis were investigated. BNIP3 expression was significantly lower in pancreatic cancer tissues compared with normal epithelia and was associated with tumor size, clinical stage, and lymph node metastasis...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28947137/hint2-triggers-mitochondrial-ca-2-influx-by-regulating-the-mitochondrial-ca-2-uniporter-mcu-complex-and-enhances-gemcitabine-apoptotic-effect-in-pancreatic-cancer
#20
Linghui Chen, Qiang Sun, Dongkai Zhou, Wei Song, Qifan Yang, Bingjie Ju, Lufei Zhang, Haiyang Xie, Lin Zhou, Zhenhua Hu, Hangping Yao, Shusen Zheng, Weilin Wang
In early studies, it was shown that HINT2, which sensitizes cells to mitochondrial apoptosis, is down-regulated in hepatocellular carcinoma (HCC) cells (Martin et al., 2006). However, the molecular mechanism of this effect is unknown. Immunohistochemistry revealed that HINT2 expression is relatively low in pancreatic cancer tissues, compared to that in adjacent tissues (P < 0.05). Furthermore, its expression was related to pathological grade and lymph node metastasis (P = 0.0161 and 0.0108, respectively); in addition, down-regulation of HINT2 was found to be associated with relatively poor prognosis in pancreatic cancer patients...
September 23, 2017: Cancer Letters
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