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https://www.readbyqxmd.com/read/27916902/synthesis-and-biological-evaluation-of-novel-aromatic-imide-polyamine-conjugates
#1
Ming Li, Yuxia Wang, Jianying Zhang, Songqiang Xie, Chaojie Wang, Yingliang Wu
Three types of conjugates in which aromatic imide scaffolds were coupled to diverse amine/polyamine motifs were synthesized, and their antitumor activities were evaluated in vitro and in vivo. Results showed that the conjugate 11e of 1,8-naphthilimide with spermine had pronounced effects on inhibiting tumor cell proliferation and inducing tumor cell apoptosis via ROS-mediated mitochondrial pathway. The in vivo assays on three H22 tumor transplant models revealed that compound 11e exerted potent ability in preventing lung cancer metastasis and extending lifespan...
November 30, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27903278/an-overview-on-the-role-of-dietary-phenolics-for-the-treatment-of-cancers
#2
REVIEW
Preethi G Anantharaju, Prathima C Gowda, Manjunatha G Vimalambike, SubbaRao V Madhunapantula
Plant derived phenolic compounds have been shown to inhibit the initiation and progression of cancers by modulating genes regulating key processes such as: (a) oncogenic transformation of normal cells; (b) growth and development of tumors; and (c) angiogenesis and metastasis. Recent studies focusing on identifying the molecular basis of plant phenolics-induced cancer cell death have demonstrated down-regulation of: (a) oncogenic survival kinases such as PI3K and Akt; (b) cell proliferation regulators that include Erk1/2, D-type Cyclins, and Cyclin Dependent Kinases (CDKs); (c) transcription factors such as NF-kβ, NRF2 and STATs; (d) histone deacetylases HDAC1 and HDAC2; and (e) angiogenic factors VEGF, FGFR1 and MIC-1...
December 1, 2016: Nutrition Journal
https://www.readbyqxmd.com/read/27899819/4-cholesten-3-one-suppresses-lung-adenocarcinoma-metastasis-by-regulating-translocation-of-hmgb1-hif1%C3%AE-and-caveolin-1
#3
Jinben Ma, Guobin Fu, Jing Wu, Shaoxian Han, Lishan Zhang, Ming Yang, Yong Yu, Mengyuan Zhang, Yanliang Lin, Yibing Wang
Metastasis is a great challenge in lung adenocarcinoma (ADC) therapy. Cholesterol has been implicated in ADC metastasis. 4-cholesten-3-one, as cholesterol metabolite and analog, can substitute membrane cholesterol and increase membrane fluidity. In this study, we explored the possibility that 4-cholesten-3-one inhibited ADC metastasis. Low-dose 4-cholesten-3-one significantly restrained ADC cells migration and invasion with little effects on cells viabilities. Further investigation showed that 4-cholesten-3-one promoted ROS generation, which transiently activated AMPKα1, increased HIF1α expression, reduced Bcl-2 expression and caused autophagy...
September 22, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27874952/nox1-promotes-colon-cancer-cell-metastasis-via-activation-of-the-adam17-pathway
#4
H-P Wang, X Wang, L-F Gong, W-J Chen, Z Hao, S-W Feng, Y-B Wu, T Ye, Y-K Cai
OBJECTIVE: Reactive oxygen species (ROS) generated by endogenous metabolic enzymes are involved in a variety of pathology processes, including cancer. In particular, superoxide-generating NADPH oxidase 1 (Nox1), a member of Nox enzyme family, is highly expressed in the colon tissue and has been implicated in physiological and pathophysiological states of colon cancer. However, the underlying molecular mechanism of Nox1 in the regulation of colon cancer progression remains largely unknown...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27856279/the-ros-mediated-activation-of-stat-3-vegf-signaling-is-involved-in-the-27-hydroxycholesterol-induced-angiogenesis-in-human-breast-cancer-cells
#5
Dongmei Zhu, Zhaoxia Shen, Jiao Liu, Juan Chen, Yun Liu, Chunyan Hu, Zhong Li, Yuan Li
Breast cancer (BC) is the leading cause of cancer-related mortality among females worldwide, and angiogenesis plays a crucial role in BC progression. 27-Hydroxycholesterol (27HC) is an endogenous selective estrogen receptor modulator, which promotes the growth and metastasis of BC. Here, we further found that, 27HC improved the angiogenic ability of BC in a VEGF-dependent manner. For the molecular mechanisms, on one hand, as an estrogen-like factor, 27HC enhanced the expression of VEGF by the classical ERα/VEGF signaling in ER-positive BC cells; on the other hand, in both ER-positive and ER-negative BC cells, 27HC enhanced the generation of ROS, which in turn activated the STAT-3/VEGF signaling in an ER independent manner...
November 14, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27836757/pm2-5-exposure-induced-autophagy-is-mediated-by-lncrna-loc146880-which-also-promotes-the-migration-and-invasion-of-lung-cancer-cells
#6
Xiaobei Deng, Nannan Feng, Min Zheng, Xiaofei Ye, Hongyan Lin, Xiao Yu, Zhihua Gan, Zheng Fang, Huan Zhang, Ming Gao, Zhi-Jie Zheng, Herbert Yu, Wenjun Ding, Biyun Qian
BACKGROUND: Evidence shows that individuals who are under long-term exposure to environmental PM2.5 are at increased risk of lung cancer. Various laboratory experiments also suggest several mechanistic links between PM2.5 exposure and lung carcinogenesis. However, a long non-coding RNA (lncRNA) mediated pathogenic change after PM2.5 exposure and its potential roles in tumorigenesis and disease progression have not been reported. METHODS: Cytotoxicity induced by PM2...
November 9, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27822409/autophagy-inhibition-promotes-epithelial-mesenchymal-transition-through-ros-ho-1-pathway-in-ovarian-cancer-cells
#7
Zhe Zhao, Jing Zhao, Jing Xue, Xinrui Zhao, Peishu Liu
Autophagy has been proved to be involved in metastasis of cancers. However, the detailed mechanisms are still unclear. In this work, we aim to provide the first study of the role that autophagy plays in migration and invasion in ovarian cancer cells. Transwell chamber was used to examine migration and invasion capacities. Western blotting and immunofluorescence were performed to investigate the expressions of mesenchymal markers (Vimentin, N-cadherin), epithelial marker (Keratin), transcript factor (Zeb1) and HO-1...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27811009/penfluridol-represses-integrin-expression-in-breast-cancer-through-induction-of-reactive-oxygen-species-and-downregulation-of-sp-transcription-factors
#8
Erik Hedrick, Xi Li, Stephen Safe
It was recently demonstrated the penfluridol inhibited breast tumor growth and metastasis and this was associated with downregulation of α6- and β4-integrins. In this study, we observed the penfluridol induced reactive oxygen species (ROS) and this was the primary mechanism of action. Penfluridol-mediated growth inhibition, induction of apoptosis, and inhibition breast cancer cell migration was attenuated after cotreatment with glutathione (GSH). Penfluridol also downregulated Sp transcription factors Sp1, Sp3 and Sp4 through epigenetic downregulation of cMyc and cMyc-regulated microRNAs (miR-27a and miR-20a/miR-17) and induction of the miR-regulated Sp transcriptional repressors ZBTB10 and ZBTB4...
November 3, 2016: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/27803929/advances-in-understanding-how-heavy-metal-pollution-triggers-gastric-cancer
#9
REVIEW
Wenzhen Yuan, Ning Yang, Xiangkai Li
With the development of industrialization and urbanization, heavy metals contamination has become a major environmental problem. Numerous investigations have revealed an association between heavy metal exposure and the incidence and mortality of gastric cancer. The mechanisms of heavy metals (lead, cadmium, mercury, chromium, and arsenic) contamination leading to gastric cancer are concluded in this review. There are four main potential mechanisms: (1) Heavy metals disrupt the gastric mucosal barrier by decreasing mucosal thickness, mucus content, and basal acid output, thereby affecting the function of E-cadherin and inducing reactive oxygen species (ROS) damage...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27779676/inhibitory-effects-of-dieckol-on-hypoxia-induced-epithelial-mesenchymal-transition-of-ht29-human-colorectal-cancer-cells
#10
Seung-Hyun Jeong, You-Jin Jeon, Sun Joo Park
Hypoxia-induced epithelial-mesenchymal transition (EMT) has been identified as essential for tumor progression and metastasis. The present study examined the effects of an antioxidant, dieckol, on hypoxia‑induced EMT in HT29 human colorectal cancer cells. HT29 cells were treated with a hypoxia‑inducing agent, CoCl2, and an increase in the levels of intracellular reactive oxygen species (ROS) and various morphological changes, such as loss of cell‑cell contact and aggressive cell migration were observed...
October 21, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27754368/antioxidant-activity-during-tumor-progression-a-necessity-for-the-survival-of-cancer-cells
#11
Mark A Hawk, Chelsea McCallister, Zachary T Schafer
Antioxidant defenses encompass a variety of distinct compounds and enzymes that are linked together through their capacity to neutralize and scavenge reactive oxygen species (ROS). While the relationship between ROS and tumorigenesis is clearly complex and context dependent, a number of recent studies have suggested that neutralizing ROS can facilitate tumor progression and metastasis in multiple cancer types through distinct mechanisms. These studies therefore infer that antioxidant activity may be necessary to support the viability and/or the invasive capacity of cancer cells during tumor progression and metastasis...
October 13, 2016: Cancers
https://www.readbyqxmd.com/read/27748761/phosphorylation-of-cofilin-1-by-erk-confers-hdac-inhibitor-resistance-in-hepatocellular-carcinoma-cells-via-decreased-ros-mediated-mitochondria-injury
#12
P-H Liao, H-H Hsu, T-S Chen, M-C Chen, C-H Day, C-C Tu, Y-M Lin, F-J Tsai, W-W Kuo, C-Y Huang
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Despite the availability of several treatment strategies, resistance to chemotherapeutic agents, which limits the effectiveness of anticancer drugs, is a major problem in cancer therapy. In this study, we used a histone deacetylases inhibitor (HDACi) to establish drug-resistant HCC cells and further analyzed the molecular mechanisms underlying the development of resistance in HCC cells. Compared with the parental cells, HDACi-resistant cells showed high metastatic and pro-survival abilities...
October 17, 2016: Oncogene
https://www.readbyqxmd.com/read/27725869/mir-300-suppresses-laryngeal-squamous-cell-carcinoma-proliferation-and-metastasis-by-targeting-ros1
#13
Wensheng Ge, Chaodong Han, Jing Wang, Yunping Zhang
Laryngeal squamous cell carcinoma (LSCC) is a common aggressive head and neck cancer with high mortality and incidence. MicroRNAs (miRNAs) are short, non-coding and endogenous RNAs that posttranscriptionally inhibit gene expression. In this study, we showed that miR-300 expression was downregulated in LSCC tissues compared with adjacent no-tumor tissues. MiR-300 overexpression inhibited Hep-2 cell proliferation, as well as the expression of ki-67 and PCNA. Moreover, overexpression of miR-300 repressed the cell invasion in Hep-2 cells...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27711726/highly-stable-selenadiazole-derivatives-induce-bladder-cancer-cell-apoptosis-and-inhibit-cell-migration-and-invasion-through-the-activation-of-ros-mediated-signaling-pathways
#14
Yahui Yang, Shulin Deng, Qinsong Zeng, Weilie Hu, Tianfeng Chen
Bladder cancer is still a common malignancy of the urinary tract due to the high metastasis rate and unexpected side effects of drug treatments. The acidic environment of the urinary bladder also strongly limits the efficacy of the chemotherapeutic agents during the treatment of bladder cancer. In this study, a series of selenadiazole derivatives (SeDs) have been rationally designed and synthesized and could actively suppress the progression and metastasis of bladder cancer cells. SeDs demonstrated better antiproliferative activity and higher stability under different physiological conditions, especially in an acidic urocystic environment, than mitomycin, a clinically used anti-bladder cancer drug...
September 23, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27698876/eupatilin-induces-human-renal-cancer-cell-apoptosis-via-ros-mediated-mapk-and-pi3k-akt-signaling-pathways
#15
Wei-Feng Zhong, Xiao-Hong Wang, Bin Pan, Feng Li, Lu Kuang, Ze-Xuan Su
Phosphatidylinositol 3-kinase (PI3K)/AKT and mitogen activated protein kinase (MAPK) signaling cascades have significant roles in cell proliferation, survival, angiogenesis and metastasis of tumor cells. Eupatilin, one of the major compounds present in Artemisia species, has been demonstrated to have antitumor properties. However, the effect of eupatilin in renal cell carcinoma (RCC) remains to be elucidated. Therefore, the present study investigated the biological effects and mechanisms of eupatilin in RCC cell apoptosis...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27685525/2-deoxy-d-glucose-enhances-dichloroacetate-antitumor-action-against-lewis-lung-carcinoma
#16
O N Pyaskovskaya, D L Kolesnik, A G Fedorchuk, I V Prokhorova, G I Solyanik
UNLABELLED: Aerobic glycolysis that supports high proliferation rate and survival of tumor cells in unfavorable conditions is among fundamental features of tumor metabolism. The search for active modulators of energetic metabolism capable of suppressing tumor growth and metastasis could result in higher effectiveness of anticancer therapy. AIM: To study antitumor and antimetastatic activity of the modulators of energetic metabolism dichloroacetate (DCA) and 2-deoxy-D-glucose (2DG) used in combination treatment of Lewis lung carcinoma (LLC)...
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27677955/role-of-oxidative-stress-in-hepatitis-c-virus-induced-hepatocellular-carcinoma
#17
Na Fu, Hui Yao, Yuemin Nan, Liang Qiao
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. Hepatitis C virus (HCV) infection is the predominant cause of chronic liver diseases and HCC, particularly in Western countries. Multiple molecular mechanisms are involved in the development and progression of HCV-related HCC, of which oxidative stress plays a pivotal role. HCV infection induces overproduction of reactive oxygen species (ROS) and impairs the function of endogenous antioxidants. Excessive amount of ROS directly damages DNA, lipids and proteins...
September 26, 2016: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/27643470/effects-of-surface-modification-of-quantum-dots-on-viability-and-migration-of-triple-negative-breast-cancer-cells
#18
Hetao Chen, Tong Wang, Kunmeng Li, Qian He, Xinyue Hou, Rui Yang, Baiqi Wang
Triple-negative breast cancer (BC) shows strong metastasis and has a bad prognosis. There are few effective approaches until date to detect BC cells at an early stage. Quantum dots (QDs) are one of the most promising nanomaterials for the detection of BC cells. QDs are usually modified with some functional molecules, such as PEG and BSA, to decrease or possibly eliminate their toxicity. Although a large number of studies have investigated the cytotoxicity of QDs, the effects of surface modification of QDs on biological behaviors of triple-negative BC cells remain unclear...
January 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27618007/bl-038-a-benzofuran-derivative-induces-cell-apoptosis-in-human-chondrosarcoma-cells-through-reactive-oxygen-species-mitochondrial-dysfunction-and-the-caspases-dependent-pathway
#19
Ju-Fang Liu, Chien-Yu Chen, Hsien-Te Chen, Chih-Shiang Chang, Chih-Hsin Tang
Chondrosarcoma is a highly malignant cartilage-forming bone tumor that has the capacity to invade locally and cause distant metastasis. Moreover, chondrosarcoma is intrinsically resistant to conventional chemotherapy or radiotherapy. The novel benzofuran derivative, BL-038 (2-amino-3-(2,6-dichlorophenyl)-6-(4-methoxyphenyl)benzofuran-4-yl acetate), has been evaluated for its anticancer effects in human chondrosarcoma cells. BL-038 caused cell apoptosis in two human chondrosarcoma cell lines, JJ012 and SW1353, but not in primary chondrocytes...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27606834/naringenin-induced-apoptotic-cell-death-in-prostate-cancer-cells-is-mediated-via-the-pi3k-akt-and-mapk-signaling-pathways
#20
Whasun Lim, Sunwoo Park, Fuller W Bazer, Gwonhwa Song
Prostate cancer is the most common cancer in men and the second most common cause of cancer-related deaths in men. Although various drugs targeting the androgen receptor are normally used, the patients frequently undergo recurrence of the disease. To overcome these limitations, natural compounds have been researched for evidence that they suppress progression and metastasis of various cancer cells. In the present study, we investigated effects of naringenin, a natural anti-oxidant flavonoid derived from citrus, on prostate cancer cells (PC3 and LNCaP)...
September 8, 2016: Journal of Cellular Biochemistry
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