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https://www.readbyqxmd.com/read/29340103/anti-neoplastic-drugs-increase-caveolin-1-dependent-migration-invasion-and-metastasis-of-cancer-cells
#1
Natalia I Díaz-Valdivia, Claudia C Calderón, Jorge E Díaz, Lorena Lobos-González, Hugo Sepulveda, Rina J Ortíz, Samuel Martinez, Veronica Silva, Horacio J Maldonado, Patricio Silva, Sergio Wehinger, Verónica A Burzio, Vicente A Torres, Martín Montecino, Lisette Leyton, Andrew F G Quest
Expression of the scaffolding protein Caveolin-1 (CAV1) enhances migration and invasion of metastatic cancer cells. Yet, CAV1 also functions as a tumor suppressor in early stages of cancer, where expression is suppressed by epigenetic mechanisms. Thus, we sought to identify stimuli/mechanisms that revert epigenetic CAV1 silencing in cancer cells and evaluate how this affects their metastatic potential. We reasoned that restricted tissue availability of anti-neoplastic drugs during chemotherapy might expose cancer cells to sub-therapeutic concentrations, which activate signaling pathways and the expression of CAV1 to favor the acquisition of more aggressive traits...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29330105/redox-regulation-of-micrornas-in-cancer
#2
Jiang Lan, Zhao Huang, Jichun Shao, Canhua Huang
Dysregulation of microRNAs (miRNAs) has long been implicated in tumorigenesis, whereas the underlying mechanisms remain largely unknown. Oxidative stress is a hallmark of cancer that involved in multiple pathophysiological processes, including the aberrant regulation of miRNAs. Compelling evidences have implied complicated interplay between reactive oxygen species (ROS) and miRNAs. Indeed, ROS induces carcinogenesis through either reducing or increasing the miRNA level, leading to the activation of oncogenes or silence of tumor suppressors, respectively...
January 9, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29306792/teaching-the-basics-of-reactive-oxygen-species-and-their-relevance-to-cancer-biology-mitochondrial-reactive-oxygen-species-detection-redox-signaling-and-targeted-therapies
#3
REVIEW
Balaraman Kalyanaraman, Gang Cheng, Micael Hardy, Olivier Ouari, Brian Bennett, Jacek Zielonka
Reactive oxygen species (ROS) have been implicated in tumorigenesis (tumor initiation, tumor progression, and metastasis). Of the many cellular sources of ROS generation, the mitochondria and the NADPH oxidase family of enzymes are possibly the most prevalent intracellular sources. In this article, we discuss the methodologies to detect mitochondria-derived superoxide and hydrogen peroxide using conventional probes as well as newly developed assays and probes, and the necessity of characterizing the diagnostic marker products with HPLC and LC-MS in order to rigorously identify the oxidizing species...
December 26, 2017: Redox Biology
https://www.readbyqxmd.com/read/29300929/downregulation-of-skp2-in-papillary-thyroid-cancer-acts-synergistically-with-trail-on-inducing-apoptosis-via-ros
#4
Poyil Pratheeshkumar, Abdul K Siraj, Sasidharan Padmaja Divya, Sandeep Kumar Parvathareddy, Rafia Begum, Roxanne Melosantos, Saif S Al-Sobhi, Mohammed Al-Dawish, Fouad Al-Dayel, Khawla S Al-Kuraya
Context and Objective: S-phase kinase protein 2 (SKP2), is an F-box protein with proteasomal properties and has been found to be overexpressed in a variety of cancers. However, its role in papillary thyroid cancer (PTC) has not been fully elucidated. Experimental Design: SKP2 expression was assessed by immunohistochemistry in a tissue microarray format on a cohort of more than 1000 PTC samples. In vitro and in vivo studies were performed using proteasome inhibitor bortezomib and proapoptopic death ligand TRAIL either alone or combination on PTC cell lines...
December 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29299971/the-role-of-the-fas-fasl-signaling-pathway-in-environmental-toxicant-induced-testicular-cell-apoptosis-an-update
#5
Mei Wang, Ping Su
The Fas/FasL signaling pathway is one of the major pathways that regulate apoptosis. Increasing studies have shown that the activation of the Fas/FasL signaling pathway is closely associated with testicular cell apoptosis. However, the mechanism involved is still unclear. We discuss recent findings regarding the molecular mechanisms by which environmental toxicants induce testicular pathology via Fas/FasL signaling. These findings suggest that Fas/FasL signaling is employed to impact the sensitivity (a response to external factors) of germ cells, disrupt steroidogenic hormone and cytokine metabolism mediated by Sertoli cells, and elicit the activation of NFAT (nuclear factor of activated T-cells) in Leydig cell apoptosis...
January 4, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29286212/knockdown-of-cpeb4-expression-suppresses-cell-migration-and-invasion-via-akt-pathway-in-non-small-cell-lung-cancer
#6
Jing Hu, LiBin Zhang, Qiang Chen, Jie Lin, ShaoBo Wang, Ri Liu, WenJing Zhang, Kun Miao, Tao Shou
Cytoplasmic polyadenylation element binding protein 4 (CPEB4) could be an important regulator in variety of cancers. However, the biological function and the underlying molecular mechanism of CPEB4 in non-small cell lung cancer (NSCLC) remains unknown. In this study, we investigated the metastasis role of CPEB4 in NSCLC cells, we knocked down CPEB4 using siRNA. Transwell migration assay and cell invasion assay on Matrigel were presented, and cell migration was also determined by scratch-healing assay. ROS generation were determined by fluorescence probe DCFH2-DA...
December 29, 2017: Cell Biology International
https://www.readbyqxmd.com/read/29236476/oxygen-self-produced-nanoplatform-for-relieving-hypoxia-and-breaking-resistance-to-sonodynamic-treatment-of-pancreatic-cancer
#7
Jie Chen, Honglin Luo, Yan Liu, Wei Zhang, Hongxue Li, Tao Luo, Kun Zhang, Yongxiang Zhao, Junjie Liu
Hypoxia as one characteristic hallmark of solid tumors has been demonstrated to be involved in cancer metastasis and progression, induce severe resistance to oxygen-dependent therapies, and hamper the transportation of theranostic agents. To address these issues, an oxygen-self-produced sonodynamic therapy (SDT) nanoplatform involving a modified fluorocarbon (FC)-chain-mediated oxygen delivery protocol has been established to realize highly efficient SDT against hypoxic pancreatic cancer. In this nanoplatform, mesopores and FC chains of FC-chain-functionalized hollow mesoporous organosilica nanoparticle carriers can provide sufficient storage capacity and binding sites for sonosensitizers (IR780) and oxygen, respectively...
December 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/29235375/chitosan-nanoparticles-loaded-hydrogels-promote-skin-wound-healing-through-the-modulation-of-reactive-oxygen-species
#8
Tao Wang, Yan Zheng, Yaping Shen, Yijie Shi, Fang Li, Chang Su, Liang Zhao
This study developed a novel bioactive chitosan nanoparticle loaded calcium alginate hydrogel to regulate inflammation and neovascularization for accelerated wound healing in vivo. It was found that chitosan nanoparticles loaded calcium alginate hydrogel exhibited remarkable antibacterial activity. Through the modulation of generation of ROS, it promoted the synthesis and secretion of IL-6 in vascular endothelial cell (VEC), suggesting its potential proinflammatory activation. Further, it promoted VEC invasion, metastasis and neovascularization to accelerate wound healing...
December 13, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29228652/clinical-characteristics-and-programmed-cell-death-ligand-1-expression-in-adenocarcinoma-in-situ-and-minimally-invasive-adenocarcinoma-of-lung
#9
Renke Yu, Zhengfu He, Ying Lou, Hanliang Jiang, Yuhui Wu, Zhen Liu, Hongming Pan, Weidong Han
Objectives: According to the IASLC/ATS/ERS 2011 classification, there are two new conceptions of lung adenocarcinoma, adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), which are very early stages of lung adenocarcinoma. This study aimed to analyze clinical features of AIS and MIA and determine the expression profile of PD-L1 in AIS and MIA. Results: In all 274 patients, 77 were diagnosed as AIS and 197 as MIA. We accidentally found 4 patients with recurrence, which were all MIA...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29215703/design-synthesis-and-characterization-of-%C3%AE-%C3%AE-unsaturated-carboxylic-acid-and-its-urea-based-derivatives-that-explores-novel-epigenetic-modulators-in-human-non-small-cell-lung-cancer-a549-cell-line
#10
Anusha Chidambaram, S H Kavya, Ramesh Kumar Chidambaram, Rajasekaran Subbiah, John Marshal Jayaraj, Karthikeyan Muthusamy, Ravikumar Vilwanathan
Histone deacetylase inhibitors (HDACi) are a small molecule chemotherapeutics that target the chromatin remodeling through the regulation of histone and non-histone proteins. These inhibitors directed against HDAC enzymes have become an important therapeutic tool in oncology; consequently, scientific efforts have fortified the quest for newer and novel HDACi, which forces the design of structurally innovative HDACi. Various urea containing compounds exhibited admirable anticancer activity. On the basis of these observations, we design and synthesize HDAC specific blocker molecules which are specifically besieged towards class I, class II and class IV HDAC isoforms to enhance the structural assortment for HDACi...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29190952/verrucarin-j-inhibits-ovarian-cancer-and-targets-cancer-stem-cells
#11
Kelsey Carter, Pranela Rameshwar, Mariusz Z Ratajczak, Sham S Kakar
Ovarian Cancer is the fifth leading cause of death among women from cancer. Cancer stem cells are a small population of cells present in cancer and the cause of chemoresistance and recurrence of cancer. We tested a new compound "Verrucarin J (VJ)", a metabolite of the Myrothecium fungus family, and showed that VJ significantly inhibits cell proliferation of both cisplatin-sensitive (A2780 and OVCAR5) and cisplatin-resistant (A2780/CP70) cell lines in a dose- and time-dependent manner with IC50 value of approximately 10 nM after 48 h of treatment...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29181405/review-of-natural-product-derived-compounds-as-potent-antiglioblastoma-drugs
#12
REVIEW
Moon Nyeo Park, Hyo Sook Song, Myungsun Kim, Min-Jung Lee, Whisung Cho, Hyun-Jin Lee, Cho-Hyun Hwang, Soojong Kim, Yechae Hwang, Beomku Kang, Bonglee Kim
Common care for glioblastoma multiforme (GBM) is a surgical resection followed by radiotherapy and temozolomide- (TMZ-) based chemotherapy. Unfortunately, these therapies remain inadequate involving severe mortality and recurrence. Recently, new approaches discovering combinations of multiple inhibitors have been proposed along with the identification of key driver mutations that are specific to each patient. To date, this approach is still limited by the lack of effective therapy. Hopefully, novel compounds derived from natural products are suggested as potential solutions...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29179443/sh003-suppresses-breast-cancer-growth-by-accumulating-p62-in-autolysosomes
#13
Youn Kyung Choi, Sung-Gook Cho, Yu-Jeong Choi, Yee Jin Yun, Kang Min Lee, Kangwook Lee, Hye-Hyun Yoo, Yong Cheol Shin, Seong-Gyu Ko
Drug markets revisits herbal medicines, as historical usages address their therapeutic efficacies with less adverse effects. Moreover, herbal medicines save both cost and time in development. SH003, a modified version of traditional herbal medicine extracted from Astragalus membranaceus (Am), Angelica gigas (Ag), and Trichosanthes Kirilowii Maximowicz (Tk) with 1:1:1 ratio (w/w) has been revealed to inhibit tumor growth and metastasis on highly metastatic breast cancer cells, both in vivo and in vitro with no toxicity...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29175458/tm4sf1-regulates-apoptosis-cell-cycle-and-ros-metabolism-via-the-ppar%C3%AE-sirt1-feedback-loop-in-human-bladder-cancer-cells
#14
Rui Cao, Gang Wang, Kaiyu Qian, Liang Chen, Lingao Ju, Guofeng Qian, Chin-Lee Wu, Han C Dan, Wei Jiang, Min Wu, Yu Xiao, Xinghuan Wang
Transmembrane-4-L-Six-Family-1 (TM4SF1) is a member of the L6 family and functions as a signal transducer to regulate cell development, growth and motility. Here we show that TM4SF1 is strongly upregulated in human muscle invasive bladder cancer (MIBC) tissues, corroborating the bioinformatical results of transcriptome analysis. Moreover, tissue microarray (TMA) shows significant correlations (p < 0.05) between high expression of TM4SF1 and T stage, TNM stage, lymph node metastasis status and survival rate of MIBC patients, indicating a positive association between TM4SF1 expression and poorer prognosis...
November 23, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29161883/targeting-oncogenic-nf-%C3%AE%C2%BAb-signaling-with-redox-active-agents-for-cancer-treatment
#15
Leyla Fouani, Zaklina Kovacevic, Des R Richardson
<b><i>Significance:</i></b> Nuclear factor kappa B (NF-κB) signaling is essential under physiologically-relevant conditions. However, aberrant activation of this pathway plays a pertinent role in tumorigenesis and contributes to resistance. <b><i>Recent Advances: </i></b>The importance of the NF-κB pathway means that its targeting must be specific to avoid side effects. For many currently used therapeutics and those under development, the ability to generate reactive oxygen species (ROS) is a promising strategy...
November 22, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29140069/dual-functions-of-cyclometalated-iridium-iii-complexes-anti-metastasis-and-lysosome-damaged-photodynamic-therapy
#16
Fang-Xin Wang, Mu-He Chen, Yan-Nan Lin, Hang Zhang, Cai-Ping Tan, Liang-Nian Ji, Zongwan Mao
Four phosphorescent cyclometalated iridium(III) complexes containing benzimidazole moiety have been designed and synthesized. These Ir(III) complexes can inhibit several cancerous processes including cell migration, invasion, colony formation and angiogenesis effectively. Interestingly, they show much higher singlet oxygen quantum yield in acidic solution than in neutral solution. Upon irradiation at 425 nm with low energy (1.2 J·cm(-2)), they can induce apoptosis through lysosomal damage, evaluation of ROS level and activation of caspase-3/7...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29136507/organelle-specific-o-glycosylation-drives-mmp14-activation-tumor-growth-and-metastasis
#17
Anh Tuan Nguyen, Joanne Chia, Manon Ros, Kam Man Hui, Frederic Saltel, Frederic Bard
Cancers grow within tissues through molecular mechanisms still unclear. Invasiveness correlates with perturbed O-glycosylation, a covalent modification of cell-surface proteins. Here, we show that, in human and mouse liver cancers, initiation of O-glycosylation by the GALNT glycosyl-transferases increases and shifts from the Golgi to the endoplasmic reticulum (ER). In a mouse liver cancer model, expressing an ER-targeted GALNT1 (ER-G1) massively increased tumor expansion, with median survival reduced from 23 to 10 weeks...
November 13, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29133897/wbscr22-confers-oxaliplatin-resistance-in-human-colorectal-cancer
#18
Dongmei Yan, Linglan Tu, Haining Yuan, Jianfei Fang, Liyan Cheng, Xiaoliang Zheng, Xiaoju Wang
Human WBSCR22 gene is involved in tumor metastasis, cell growth and invasion, however, its role in chemosensitivity to antitumor agents remains unknown. In this study, we analyzed the TCGA cohort and found the expression of WBSCR22 was significantly elevated in human colorectal cancer (CRC) tissue. WBSCR22 could be served as an independent risk predictor for overall survival (OS), and up-regulated WBSCR22 could predict unfavorable OS for CRC patients. Knockdown of WBSCR22 significantly sensitized CRC cells to oxaliplatin in vitro and in vivo, while overexpression of WBSCR22 led to cellular resistance to oxaliplatin treatment...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133040/synthesis-and-biological-evaluation-of-novel-alkylated-polyamine-analogues-as-potential-anticancer-agents
#19
Meng Li, Yuxia Wang, Chaochao Ge, Liping Chang, Chaojie Wang, Zhiyong Tian, Senzhen Wang, Fujun Dai, Luyao Zhao, Songqiang Xie
A new class of polyamine analogues modified by alkylation at the terminal of the polyamine chain has been synthesized and their structures were determined by (1)H NMR, (13)C NMR, ESI-MS and elemental analysis. As the representative compound, 3f displayed a broad spectrum of anti-cancer effects by MTT assays. Tumor xenograft model and pulmonary metastasis model showed that compound 3f significantly suppressed tumor growth and metastasis in vivo, which was more stronger than the reference drug amonafide. Molecular mechanisms indicated that compound 3f exhibited antiproliferative activities and induced the generation of reactive oxygen species (ROS), which resulted in the occurrence of autophagy...
November 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29123322/hypoxia-induced-reactive-oxygen-species-mediate-n-cadherin-and-serpine1-expression-egfr-signalling-and-motility-in-mda-mb-468-breast-cancer-cells
#20
Iman Azimi, Rosalie M Petersen, Erik W Thompson, Sarah J Roberts-Thomson, Gregory R Monteith
One of the hallmarks of the tumour microenvironment is hypoxia resulting from increased oxygen consumption by proliferative cancer cells and altered vasculature. Hypoxic tension initiates various cellular signals and can drive epithelial to mesenchymal transition (EMT), a process important in cancer progression. In this study, using the antioxidant N-acetylcysteine (NAC), we show that hypoxia-induced reactive oxygen species (ROS) in MDA-MB-468 breast cancer cells, selectively regulate hypoxia-induced increases in N-cadherin and SERPINE1, two proteins involved in cell adhesion...
November 9, 2017: Scientific Reports
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