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https://www.readbyqxmd.com/read/28103621/development-and-validation-of-a-training-module-on-the-use-of-acetic-acid-for-the-detection-of-barrett-s-neoplasia
#1
Fergus J Q Chedgy, Kesavan Kandiah, Hugh Barr, Simon Dwerryhouse, Balint Eross, Charles Gordon, Susi Green, Andy Li, James Brown, Gaius Longcroft-Wheaton, Pradeep Bhandari
Background and study aims Acetic acid chromoendoscopy (AAC) enhances the ability to correctly identify Barrett's neoplasia, and is increasingly used by both expert and nonexpert endoscopists. Despite its increasing use, there is no validated training strategy to achieve competence. The aims of our study were to develop a validated training tool in AAC-assisted lesion recognition, to assess endoscopists' baseline knowledge of AAC-assisted lesion recognition, and to evaluate the efficacy and impact of this training tool...
January 19, 2017: Endoscopy
https://www.readbyqxmd.com/read/28103459/-cultural-competence-in-intervention-with-immigrants-a-comparative-analysis-between-health-professionals-social-workers-and-police-officers
#2
Mariana Gonçalves, Marlene Matos
INTRODUCTION: Cultural diversity places increased demands on services to multicultural populations, so the development of cultural competence by help professionals is currently a concern in institutional practices. MATERIAL AND METHODS: This study evaluated the perception of cultural competence of help professional of three distinct areas: health services, social services and criminal police. Through an online questionnaire, we questioned the perception of cultural competence, at four dimensions: cultural awareness, cultural knowledge, technical skills, and organizational support...
October 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28103451/-comment-to-the-paper-cultural-competence-in-intervention-with-immigrants-a-comparative-analysis-between-health-professionals-social-workers-and-police-officers
#3
EDITORIAL
Fernando Luís Machado
No abstract text is available yet for this article.
October 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28103319/an-hsv-2-trivalent-vaccine-is-immunogenic-in-rhesus-macaques-and-highly-efficacious-in-guinea-pigs
#4
Sita Awasthi, Lauren M Hook, Carolyn E Shaw, Bapi Pahar, Jacob A Stagray, David Liu, Ronald S Veazey, Harvey M Friedman
A genital herpes vaccine is urgently needed to prevent pain and suffering, reduce the incidence of neonatal herpes, and decrease the risk of HIV acquisition and transmission that accompanies genital infection. We evaluated a trivalent HSV-2 subunit antigen vaccine administered with CpG and alum in rhesus macaques and guinea pigs. The vaccine contains glycoproteins C, D and E (gC2, gD2, gE2) to block virus entry by gD2 and immune evasion by gC2 and gE2. In rhesus macaques, the trivalent vaccine induced plasma and mucosa neutralizing antibodies, antibodies that block gC2 and gE2 immune evasion activities, and stimulated CD4 T cell responses...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28103289/cost-effectiveness-analysis-of-five-competing-strategies-for-the-management-of-multiple-recurrent-community-onset-clostridium-difficile-infection-in-france
#5
Emilie Baro, Tatiana Galperine, Fanette Denies, Damien Lannoy, Xavier Lenne, Pascal Odou, Benoit Guery, Benoit Dervaux
BACKGROUND: Clostridium difficile infection (CDI) is characterized by high rates of recurrence, resulting in substantial health care costs. The aim of this study was to analyze the cost-effectiveness of treatments for the management of second recurrence of community-onset CDI in France. METHODS: We developed a decision-analytic simulation model to compare 5 treatments for the management of second recurrence of community-onset CDI: pulsed-tapered vancomycin, fidaxomicin, fecal microbiota transplantation (FMT) via colonoscopy, FMT via duodenal infusion, and FMT via enema...
2017: PloS One
https://www.readbyqxmd.com/read/28103159/the-effects-of-stimulant-medication-and-training-on-sports-competence-among-children-with-adhd
#6
Amy R Altszuler, Anne S Morrow, Brittany M Merrill, Shannon Bressler, Fiona L Macphee, Elizabeth M Gnagy, Andrew R Greiner, Stefany Coxe, Joseph S Raiker, Erika Coles, William E Pelham
The current study examined the relative efficacy of behavioral sports training, medication, and their combination in improving sports competence among youth with attention deficit/hyperactivity disorder (ADHD). Participants were 73 youth (74% male; 81% Hispanic) between the ages of 5 and 12 diagnosed with Diagnostic and Statistical Manual of Mental Disorders (4th ed.) ADHD enrolled in a Summer Treatment Program (STP). The study consisted of a 2 (medication: methylphenidate, placebo) × 2 (sports training: instruction and practice, recreational play) between-groups design and was conducted over a 3-week period during the STP...
January 19, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28102968/thoracic-ultrasound-recognition-of-competence-a-position-paper-of-the-thoracic-society-of-australia-and-new-zealand
#7
Jonathan P Williamson, Scott H Twaddell, Y C Gary Lee, Matthew Salamonsen, Mark Hew, David Fielding, Phan Nguyen, Daniel Steinfort, Peter Hopkins, Nicola Smith, Christopher Grainge
The ability to perform bedside thoracic ultrasound is increasingly recognized as an essential skill for thoracic clinicians, extending the clinical examination and aiding diagnostic and therapeutic procedures. Thoracic ultrasound reduces complications and increases success rates when used prior to thoracentesis or intercostal chest tube insertion. It is increasingly difficult to defend performing these procedures without real or near-real time image guidance. To assist thoracic physicians and others achieve and demonstrate thoracic ultrasound competence, the Interventional Pulmonology Special Interest Group (IP-SIG) of the Thoracic Society of Australia and New Zealand (TSANZ) has developed a new pathway with four components: (i) completion of an approved thoracic ultrasound theory and hands-on teaching course...
February 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28102845/h19-let-7-lin28-reciprocal-negative-regulatory-circuit-promotes-breast-cancer-stem-cell-maintenance
#8
Fei Peng, Ting-Ting Li, Kai-Li Wang, Guo-Qing Xiao, Ju-Hong Wang, Hai-Dong Zhao, Zhi-Jie Kang, Wen-Jun Fan, Li-Li Zhu, Mei Li, Bai Cui, Fei-Meng Zheng, Hong-Jiang Wang, Eric W-F Lam, Bo Wang, Jie Xu, Quentin Liu
Long noncoding RNA-H19 (H19), an imprinted oncofetal gene, has a central role in carcinogenesis. Hitherto, the mechanism by which H19 regulates cancer stem cells, remains elusive. Here we show that breast cancer stem cells (BCSCs) express high levels of H19, and ectopic overexpression of H19 significantly promotes breast cancer cell clonogenicity, migration and mammosphere-forming ability. Conversely, silencing of H19 represses these BCSC properties. In concordance, knockdown of H19 markedly inhibits tumor growth and suppresses tumorigenesis in nude mice...
January 19, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28102797/why-undertake-a-pilot-in-a-qualitative-phd-study-lessons-learned-to-promote-success
#9
Jane Wray, Uduak Archibong, Sean Walton
Background Pilot studies can play an important role in qualitative studies. Methodological and practical issues can be shaped and refined by undertaking pilots. Personal development and researchers' competence are enhanced and lessons learned can inform the development and quality of the main study. However, pilot studies are rarely published, despite their potential to improve knowledge and understanding of the research. Aim To present the main lessons learned from undertaking a pilot in a qualitative PhD study...
January 23, 2017: Nurse Researcher
https://www.readbyqxmd.com/read/28102571/developing-a-cultural-competence-inventory-for-nurses-in-china
#10
D Cai, W Kunaviktikul, A Klunklin, A Sripusanapan, P K Avant
AIM: To develop and psychometrically test the Cultural Competence Inventory for Nurses in China. BACKGROUND: Cultural competence is expected worldwide from nurses due to the increasing cultural diversity of people in healthcare establishments. Yet, no cultural competence framework or instrument for nurses has been identified to guide nursing practice in China where the cultural diversity of the populations and the characteristics of the healthcare system are different from those of the West...
January 19, 2017: International Nursing Review
https://www.readbyqxmd.com/read/28102550/accounting-for-competing-risks-in-randomized-controlled-trials-a-review-and-recommendations-for-improvement
#11
Peter C Austin, Jason P Fine
In studies with survival or time-to-event outcomes, a competing risk is an event whose occurrence precludes the occurrence of the primary event of interest. Specialized statistical methods must be used to analyze survival data in the presence of competing risks. We conducted a review of randomized controlled trials with survival outcomes that were published in high-impact general medical journals. Of 40 studies that we identified, 31 (77.5%) were potentially susceptible to competing risks. However, in the majority of these studies, the potential presence of competing risks was not accounted for in the statistical analyses that were described...
January 19, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28102467/mypod-an-emr-based-tool-that-facilitates-quality-improvement-and-maintenance-of-certification
#12
Loren Berman, Brian Duffy, B Randall Brenn, Charles Vinocur
Maintenance of Certification (MOC) was designed to assess physician competencies including operative case volume and outcomes. This information, if collected consistently and systematically, can be used to facilitate quality improvement. Information automatically extracted from the electronic medical record (EMR) can be used as a prompt to compile these data. We developed an EMR-based program called MyPOD (My Personal Outcomes Data) to track surgical outcomes at our institution. We compared occurrences reported in the first 18 months to those captured in the American College of Surgeons National Surgical Quality Improvement Program-Pediatric (ACS NSQIP-P) over the same time period...
March 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28102267/a-theoretical-foundation-for-multi-scale-regular-vegetation-patterns
#13
Corina E Tarnita, Juan A Bonachela, Efrat Sheffer, Jennifer A Guyton, Tyler C Coverdale, Ryan A Long, Robert M Pringle
Self-organized regular vegetation patterns are widespread and thought to mediate ecosystem functions such as productivity and robustness, but the mechanisms underlying their origin and maintenance remain disputed. Particularly controversial are landscapes of overdispersed (evenly spaced) elements, such as North American Mima mounds, Brazilian murundus, South African heuweltjies, and, famously, Namibian fairy circles. Two competing hypotheses are currently debated. On the one hand, models of scale-dependent feedbacks, whereby plants facilitate neighbours while competing with distant individuals, can reproduce various regular patterns identified in satellite imagery...
January 18, 2017: Nature
https://www.readbyqxmd.com/read/28101986/size-dependent-activity-of-palladium-nanoparticles-pd-nps-efficient-conversion-of-co2-into-formate-at-low-overpotentials
#14
Motiar Rahaman, Abhijit Dutta, Peter Broekmann
We report a remarkable size-dependent activity of palladium nanoparticles towards formate production at very low overpotentials (-0.1 V to -0.5 V vs RHE). Size-selective Pd-NPs have been chemically synthesized in the range from 3.8nm to 10.7nm. Electrochemical CO₂ reduction reaction was carried out in aqueous 0.5M NaHCO₃ solution. The Faradaic efficiency of formate production (FE/formate) exceeds more than 86% at E = -0.1 V vs RHE on 3.8nm Pd-NPs whereas on 6.5 nm Pd-NPs an even higher FEformate of 98% is observed...
January 19, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28101974/etiquette-competence-and-professionalism-the-profile-of-the-ideal-pediatric-anesthesiologist
#15
EDITORIAL
Karin Becke, Martin Jöhr
No abstract text is available yet for this article.
February 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28101925/-watch-out-effects-of-instructed-threat-and-avoidance-on-human-free-operant-approach-avoidance-behavior
#16
Michael W Schlund, Kay Treacher, Oli Preston, Sandy K Magee, David M Richman, Adam T Brewer, Gemma Cameron, Simon Dymond
Approach-avoidance paradigms create a competition between appetitive and aversive contingencies and are widely used in nonhuman research on anxiety. Here, we examined how instructions about threat and avoidance impact control by competing contingencies over human approach-avoidance behavior. Additionally, Experiment 1 examined the effects of threat magnitude (money loss amount) and avoidance cost (fixed ratio requirements), whereas Experiment 2 examined the effects of threat information (available, unavailable and inaccurate) on approach-avoidance...
January 2017: Journal of the Experimental Analysis of Behavior
https://www.readbyqxmd.com/read/28101631/lumbar-and-sacral-pedicle-screw-placement-using-a-template-does-not-improve-the-midterm-pain-and-disability-outcome-in-comparison-with-free-hand-method
#17
Matjaz Merc, Gregor Recnik, Zmago Krajnc
BACKGROUND: The free-hand technique carries a higher risk of pedicle weakening and neurovascular injuries in comparison with pedicle screw placement using a drill guide. Due to this evidence and because of some variances in the surgical method, different outcome can be expected. The objective of the study was to evaluate the disability, the back and leg pain before and at least 3 years after the surgery between examined groups. MATERIALS AND METHODS: Eleven patients in drill guide and 13 in control group were randomly assigned for vertebral fusion in the lumbar and first sacral regions...
January 19, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28100678/modulation-of-naive-cd8-t-cell-response-features-by-ligand-density-affinity-and-continued-signaling-via-internalized-tcrs
#18
Renu Balyan, Rupali Gund, Chitra Ebenezer, Jasneet Kaur Khalsa, Divya Anna Verghese, Thyagarajan Krishnamurthy, Anna George, Vineeta Bal, Satyajit Rath, Ashutosh Chaudhry
T cell response magnitudes increase with increasing antigenic dosage. However, it is unclear whether ligand density only modulates the proportions of responding ligand-specific T cells or also alters responses at the single cell level. Using brief (3 h) exposure of TCR-transgenic mouse CD8 T cells in vitro to varying densities of cognate peptide-MHC ligand followed by ligand-free culture in IL-2, we found that ligand density determined the frequencies of responding cells but not the expression levels of the early activation marker molecule, CD69...
January 18, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28100667/the-control-of-translational-accuracy-is-a-determinant-of-healthy-ageing-in-yeast
#19
Tobias von der Haar, Jane E Leadsham, Aimie Sauvadet, Daniel Tarrant, Ilectra S Adam, Kofo Saromi, Peter Laun, Mark Rinnerthaler, Hannelore Breitenbach-Koller, Michael Breitenbach, Mick F Tuite, Campbell W Gourlay
Life requires the maintenance of molecular function in the face of stochastic processes that tend to adversely affect macromolecular integrity. This is particularly relevant during ageing, as many cellular functions decline with age, including growth, mitochondrial function and energy metabolism. Protein synthesis must deliver functional proteins at all times, implying that the effects of protein synthesis errors like amino acid misincorporation and stop-codon read-through must be minimized during ageing. Here we show that loss of translational accuracy accelerates the loss of viability in stationary phase yeast...
January 2017: Open Biology
https://www.readbyqxmd.com/read/28100625/the-ptpn14-tumour-suppressor-is-a-degradation-target-of-human-papillomavirus-e7
#20
Anita Szalmás, Vjekoslav Tomaić, Om Basukala, Paola Massimi, Suruchi Mittal, József Kónya, Lawrence Banks
: Activation of signalling pathways ensuring cell growth are essential for the proliferative competence of human papillomavirus (HPV)-infected cells. Tyrosine kinases and phosphatases are key regulators of cellular growth control pathways. A recently identified potential cellular target of HPV E7 is the cytoplasmic protein tyrosine phosphatase PTPN14, which is a potential tumour suppressor and is linked to the control of the Hippo and Wnt/beta-catenin signalling pathways. In this study we show that the E7 proteins of both high-risk and low-risk mucosal HPV types can interact with PTPN14...
January 18, 2017: Journal of Virology
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