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https://www.readbyqxmd.com/read/28551586/analysis-of-2d-nmr-relaxation-data-using-chisholm-approximations
#1
S Huber, A Haase, B Gleich
To analyze 2D NMR relaxation data based on a discrete delta-like relaxation map we extended the Padé-Laplace method to two dimensions. We approximate the forward Laplace image of the time domain signal by a Chisholm approximation, i.e. a rational polynomial in two dimensions. The poles and residues of this approximation correspond to the relaxation rates and weighting factors of the underlying relaxation map. In this work we explain the principle ideas of our algorithm and demonstrate its applicability. Therefore we compare the inversion results of the Chisholm approximation and Tikhonov regularization method as a function of SNR when the investigated signal is based on a given discrete relaxation map...
May 19, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28551477/an-evaluation-of-approaches-used-to-teach-quality-improvement-to-pre-registration-healthcare-professionals-an-integrative-review
#2
REVIEW
Lorraine Armstrong, Ashley Shepherd, Fiona Harris
BACKGROUND: Improving the quality of healthcare remains central to UK and international policy, practice and research. In 2003, The Institute of Medicine's 'Health Professions Education: A Bridge to Quality', advocated quality improvement as a core competency for all healthcare professionals. As a result, developing capacity and capability of those applying improvement methodologies in the pre-registration population has risen, yet, little is known about the teaching approaches employed for this purpose...
May 22, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28551461/revisiting-the-value-of-competition-assays-in-folate-receptor-mediated-drug-delivery
#3
Steven K Jones, Anwesha Sarkar, Daniel P Feldmann, Peter Hoffmann, Olivia M Merkel
Polymeric nanoparticles have been studied for gene and drug delivery. These nanoparticles can be modified to utilize a targeted delivery approach to selectively deliver their payload to specific cells, while avoiding unwanted delivery to healthy cells. One commonly over-expressed receptor which can be targeted by ligand-conjugated nanoparticles is the folate receptor alpha (FRα). The ability to target FRα remains a promising concept, and therefore, understanding the binding dynamics of the receptor with the ligand of the nanoparticle therapeutic can provide valuable insight...
May 22, 2017: Biomaterials
https://www.readbyqxmd.com/read/28551107/neurobiology-of-schemas-and-schema-mediated-memory
#4
REVIEW
Asaf Gilboa, Hannah Marlatte
Schemas are superordinate knowledge structures that reflect abstracted commonalities across multiple experiences, exerting powerful influences over how events are perceived, interpreted, and remembered. Activated schema templates modulate early perceptual processing, as they get populated with specific informational instances (schema instantiation). Instantiated schemas, in turn, can enhance or distort mnemonic processing from the outset (at encoding), impact offline memory transformation and accelerate neocortical integration...
May 24, 2017: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/28550911/impact-of-the-introduction-of-electronic-prescribing-on-staff-perceptions-of-patient-safety-and-organizational-culture
#5
James Davies, Philip H Pucher, Heba Ibrahim, Ben Stubbs
BACKGROUND: Electronic prescribing (EP) systems are online technology platforms by which medicines can be prescribed, administered, and stock controlled. The actual impact of EP on patient safety is not truly understood. This study seeks to assess the impact of the implementation of an EP system on safety culture, as well as assessing differences between clinical respondent groups and considering their implications. METHODS: Staff completed a modified Safety Attitudes Questionnaire survey, 6 weeks following the introduction of EP across surgical services in a hospital in Dorset, England...
May 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28550828/-pedagogical-professional-development-of-medical-teachers-the-experience-of-nova-medical-school-universidade-nova-de-lisboa
#6
Joana Marques, Patrícia Rosado-Pinto
INTRODUCTION: To be a college teacher requires a permanent effort in developing specific competencies, namely in the pedagogical domain. This paper aims both to describe the pedagogical professional development program offered by the Medical Education Office of NOVA Medical School of Universidade Nova de Lisboa and to analyse its role in the enhancement of reflection around curriculum and teaching practice. MATERIAL AND METHODS: Description of the pedagogical programme offered between 2010 and 2016...
March 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28550684/long-noncoding-rna-ccat2-knockdown-suppresses-tumorous-progression-by-sponging-mir-424-in-epithelial-ovarian-vancer
#7
Fu Hua, Chang-Hua Li, Xiao-Gang Chen, Xiao-Ping Liu
Epithelial ovarian cancer (EOC) is the one of most common gynecological malignant tumor with highest mortality, meanwhile, series of lncRNAs have been validated to play vital role in EOC tumorigenesis. Colon cancer-associated transcript 2 (CCAT2) has been verified as oncogenic lncRNA in multiple tumors, however, the role of CCAT2 in EOC genesis is still unclear. The purpose of present study is to probe the function of CCAT2 on EOC. Preliminary experiments found that CCAT2 expression was significantly up-regulated in EOC tissue and cell lines compared to noncancerous tissue and cells...
May 21, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550487/model-to-predict-cause-specific-mortality-in-patients-with-head-and-neck-adenoid-cystic-carcinoma-a-competing-risk-analysis
#8
EDITORIAL
Matin Imanguli, Baran D Sumer
No abstract text is available yet for this article.
May 26, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28550380/barriers-motivators-and-facilitators-to-engagement-in-hiv-care-among-hiv-infected-ghanaian-men-who-have-sex-with-men-msm
#9
Adedotun Ogunbajo, Trace Kershaw, Sameer Kushwaha, Francis Boakye, Nii-Dromo Wallace-Atiapah, LaRon E Nelson
In Ghana, men who have sex with men (MSM) bear a high burden of HIV. Identifying factors that influence engagement in HIV care among HIV-infected Ghanaian MSM is critical to devising novel interventions and strengthening existing programs aimed at improving outcomes across the HIV care continuum. Consequently, we conducted an exploratory qualitative research study with 30 HIV-infected Ghanaian MSM between May 2015 and July 2015. Common barriers were fear of being seen in HIV-related health facility, financial difficulties, and health system challenges...
May 26, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28550379/a-mixed-methods-exploration-of-the-needs-of-people-living-with-hiv-plwh-enrolled-in-access-to-care-a-national-hiv-linkage-retention-and-re-engagement-in-medical-care-program
#10
C Maulsby, B Enobun, D S Batey, K M Jain, M Riordan, M Werner, D R Holtgrave
Competing needs pose barriers to engagement in HIV medical care. Mixed methods were used to explore and describe the needs of participants enrolled in Access to Care, a national HIV linkage, retention and re-engagement in care (LRC) program that served people living with HIV who knew their status but were not engaged in care. When asked to prioritize their most urgent needs, participants reported housing or shelter (31%), HIV medical services (24%), and employment (8%). When we assessed the HIV continuum of care by needs status, we found no significant differences in linkage, retention, or viral suppression between participants with and without basic needs...
May 26, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28550157/competence-consent-and-complexity
#11
EDITORIAL
Ken Boyd
No abstract text is available yet for this article.
June 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28549819/rivaroxaban-for-stroke-prevention-in-patients-with-nonvalvular-atrial-fibrillation-and-active-cancer
#12
Eva S Laube, Anthony Yu, Dipti Gupta, Yimei Miao, Patrick Samedy, Jonathan Wills, Stephen Harnicar, Gerald A Soff, Simon Mantha
Rivaroxaban is broadly used for the primary prevention of stroke and systemic embolism in the general population with nonvalvular atrial fibrillation (AF). However, there is little published evidence on the safety and efficacy of rivaroxaban for AF in patients with active cancer. The aim of this study was to assess the safety and efficacy of rivaroxaban in patients with active cancer and AF. The use of rivaroxaban in patients with cancer at the Memorial Sloan Kettering Cancer Center is monitored in the setting of a Quality Assessment Initiative...
April 27, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28549712/assessment-of-competence-in-evar-procedures-a-novel-rating-scale-developed-by-the-delphi-technique
#13
M Strøm, L Lönn, B Bech, T V Schroeder, L Konge
OBJECTIVE/BACKGROUND: To develop a procedure specific global rating scale for assessment of operator competence in endovascular aortic repair (EVAR). METHODS: A Delphi approach was used to achieve expert consensus. A panel of 32 international experts (median 300 EVAR procedures, range 200-3000) from vascular surgery (n = 21) and radiology (n = 11) was established. The first Delphi round was based on a review of endovascular skills assessment papers, stent graft instructions for use, and structured interviews...
May 23, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28549625/a-matter-of-maturity-the-impact-of-pre-mrna-processing-in-gene-expression-and-antigen-presentation
#14
Rodrigo Prado Martins, Robin Fåhraeus
RNA processing plays a pivotal role in the diversification of high eukaryotes transcriptome and proteome. The expression of gene products controlling a variety of cellular and physiological processes depends largely on a complex maturation process undergone by pre-mRNAs to become translation-competent mRNAs. Here we review the different mechanisms involved in the pre-mRNA processing and disclose their impact in the gene regulation process in eukaryotic cells. We describe some viral strategies targeting pre-mRNA processing to control gene expression and host immune response and discuss their relevance as tools for a better understanding of cell biology...
May 23, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28549577/-child-behaviour-problems-and-parenting-skills-of-mothers-in-environments-of-intimate-partner-violence
#15
Ana Rosser Limiñana, Raquel Suriá Martínez, Miguel Ángel Mateo Pérez
OBJECTIVE: To assess the behavioural problems of children who have been exposed to intimate partner violence situations, and the moderating effect of mother parenting. METHOD: We analysed, using the Child Behavior CheckList, behavioural problems of 46 children between 6 and 16 years, and the relationship between the detected problems and parenting skills shown in the mother-child interaction in shelters. RESULTS: Increased behavioural problems were detected in children, compared with normative population...
May 23, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28549513/assessment-of-the-accuracy-and-consistency-in-the-application-of-standardized-surveillance-definitions-a-summary-of-the-american-journal-of-infection-control-and-national-healthcare-safety-network-case-studies-2010-2016
#16
Marc-Oliver Wright, Katherine Allen-Bridson, Joan N Hebden
BACKGROUND: The Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN) surveillance definitions are the most widely used criteria for health care-associated infection (HAI) surveillance. NHSN participants agree to conduct surveillance in accordance with the NHSN protocol and criteria. To assess the application of these standardized surveillance specifications and offer infection preventionists (IPs) opportunities for ongoing education, a series of case studies, with questions related to NHSN definitions and criteria were published...
June 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28549510/understanding-the-current-state-of-infection-preventionists-through-competency-role-and-activity-self-assessment
#17
Ericka L Kalp, James F Marx, James Davis
BACKGROUND: The Association for Professionals in Infection Control and Epidemiology (APIC) MegaSurvey, administered in 2015, was completed by approximately 4,079 APIC members. The survey sought to gain a better understanding the current state of 4 components of infection prevention practice: demographic characteristics, compensation, organizational structure, and practice and competency. METHODS: The data for this analysis come from the APIC MegaSurvey Practice and Competency domain...
June 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28549463/factors-associated-with-length-of-stay-following-trans-catheter-aortic-valve-replacement-a-multicenter-study
#18
Yaron Arbel, Nevena Zivkovic, Dhruven Mehta, Sam Radhakrishnan, Stephen E Fremes, Effat Rezaei, Asim N Cheema, Sami Al-Nasser, Ariel Finkelstein, Harindra C Wijeysundera
BACKGROUND: Most patients undergoing Transcatheter aortic valve implantation (TAVR) are elderly with significant co-morbidities and there is limited information available regarding factors that influence length of stay (LOS) post-procedure. The aim of this study was to identify the patient, and procedural factors that affect post-TAVR LOS using a contemporary multinational registry. METHODS: We conducted a retrospective cohort study, with patients recruited from three high volume tertiary institutions...
May 26, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28549461/the-effect-of-white-coats-and-gender-on-medical-students-perceptions-of-physicians
#19
Malika Ladha, Aleem Bharwani, Kevin McLaughlin, Henry T Stelfox, Adam Bass
BACKGROUND: Despite the fact that medical schools spend a considerable effort to rate clinical instructors, there is limited evidence regarding the effect of physical characteristics on instructor ratings. White coats have been shown to alter patients' perceptions of physicians although it has not been determined if preceptors who wear white coats are rated differently than their colleagues. METHODS: Second year medical students were administered a questionnaire with four clinical scenarios depicting medical errors accompanied by a picture of a physician of different sexes and ethnicities...
May 26, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28549459/-a-steep-learning-curve-junior-doctor-perspectives-on-the-transition-from-medical-student-to-the-health-care-workplace
#20
Nancy Sturman, Zachary Tan, Jane Turner
BACKGROUND: The transition from medical student to hospital-based first year junior doctor (termed "intern" in Australia) is known to be challenging, and recent changes in clinical learning environments may reduce graduate preparedness for the intern workplace. Although manageable challenges and transitions are a stimulus to learning, levels of burnout in junior medical colleagues are concerning. In order to prepare and support medical graduates, educators need to understand contemporary junior doctor perspectives on this transition...
May 26, 2017: BMC Medical Education
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