Yaoying Long, Bianlei Yang, Qian Lei, Fei Gao, Li Chen, Wenlan Chen, Siyi Chen, Wenxiang Ren, Yulin Cao, Liuyue Xu, Di Wu, Jiao Qu, He Li, Yali Yu, Anyuan Zhang, Shan Wang, Weiqun Chen, Hongxiang Wang, Ting Chen, Zhichao Chen, Qiubai Li
Type 2 alveolar epithelial cell (AEC2) senescence is crucial to the pathogenesis of pulmonary fibrosis (PF). The nicotinamide adenine dinucleotide (NAD+ )-consuming enzyme cluster of differentiation 38 (CD38) is a marker of senescent cells and is highly expressed in AEC2s of patients with PF, thus rendering it a potential treatment target. Umbilical cord mesenchymal stem cell (MSC)-derived extracellular vesicles (MSC-EVs) have emerged as a cell-free treatment with clinical application prospects in antiaging and antifibrosis treatments...
February 21, 2024: ACS Nano