Aixiang Liu, Xin Li, Lisha Zhou, Xiaoqing Yan, Na Xia, Zhanfei Song, Jingjing Cao, Zhongsuo Hao, Zhihong Zhang, Ruifeng Liang, Hongmei Zhang
Benzo[a]pyrene (B[a]P), one typical environmental pollutant, the toxicity mechanisms, and potential prevention remain perplexing. Available evidence suggests cytochrome P450 1A1 (CYP1A1) and glutathione S-transferases (GSTs) metabolize B[a]P, resulting in metabolic activation and detoxification of B[a]P. This study aimed to reveal the impact of B[a]P exposure on trans-7,8-diol-anti-9,10-epoxide DNA (BPDE-DNA) adduct formation, level of CYP1A1, glutathione S-transferase pi (GSTP1) and glutathione S-transferase mu1 (GSTM1) mRNA, protein and DNA methylation in mice, and the potential prevention of aspirin (ASP)...
October 2023: Environmental Science and Pollution Research International