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https://www.readbyqxmd.com/read/28738403/developing-consensus-based-priority-outcome-domains-for-trials-in-kidney-transplantation-a-multinational-delphi-survey-with-patients-caregivers-and-health-professionals
#1
Bénédicte Sautenet, Allison Tong, Karine E Manera, Jeremy R Chapman, Anthony N Warrens, David Rosenbloom, Germaine Wong, John Gill, Klemens Budde, Lionel Rostaing, Lorna Marson, Michelle A Josephson, Peter P Reese, Timothy L Pruett, Camilla S Hanson, Donal O'Donoghue, Helen Tam-Tham, Jean-Michel Halimi, Jenny I Shen, John Kanellis, John D Scandling, Kirsten Howard, Martin Howell, Nick Cross, Nicole Evangelidis, Philip Masson, Rainer Oberbauer, Samuel Fung, Shilpa Jesudason, Simon Knight, Sreedhar Mandayam, Stephen P McDonald, Steve Chadban, Tasleem Rajan, Jonathan C Craig
BACKGROUND: Inconsistencies in outcome reporting and frequent omission of patient-centered outcomes can diminish the value of trials in treatment decision making. We identified critically important outcome domains in kidney transplantation based on the shared priorities of patients/caregivers and health professionals. METHODS: In a 3-round Delphi survey, patients/caregivers and health professionals rated the importance of outcome domains for trials in kidney transplantation on a 9-point Likert scale and provided comments...
August 2017: Transplantation
https://www.readbyqxmd.com/read/28737998/examination-of-the-patient-focused-impact-of-cancer-telegenetics-among-a-rural-population-comparison-with-traditional-in-person-services
#2
Nan M Solomons, Amanda E Lamb, Frances L Lucas, Eileen F McDonald, Susan Miesfeldt
BACKGROUND: Telecommunication models promise to improve access to cancer genetic counseling. Little is known about their impact among the geographically underserved. This work examined knowledge and emotional outcomes and attitudes/beliefs regarding cancer telegenetic services (via live-interactive videoconferencing) in Maine. MATERIALS AND METHODS: Cancer telegenetic patients seen at two remote sites and control (in-person) patients responded to pre-/postsurveys assessing care impact on hereditary breast and ovarian cancer (HBOC) knowledge and emotional health, ease of access to services, and telegenetics satisfaction/acceptability...
July 21, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28737634/noise-reduction-to-reduce-patient-anxiety-during-cast-removal-can-we-decrease-patient-anxiety-with-cast-removal-by-wearing-noise-reduction-headphones-during-cast-saw-use
#3
Susan T Mahan, Marie S Harris, Anneliese M Lierhaus, Patricia E Miller, Rachel L DiFazio
BACKGROUND: Noise reduction headphones decrease the sound during cast removal. Their effectiveness in decreasing anxiety has not been studied. PURPOSE: Compare pediatric patients' anxiety levels during cast removal with and without utilization of noise reduction headphones combined with use of a personal electronic device. METHODS: Quality improvement project. Patients randomly assigned to noise reduction headphone group or standard care group during cast removal...
July 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/28737585/biomarkers-in-sports-and-exercise-tracking-health-performance-and-recovery-in-athletes
#4
Elaine C Lee, Maren S Fragala, Stavros A Kavouras, Robin M Queen, J Luke Pryor, Douglas J Casa
Biomarker discovery and validation is a critical aim of the medical and scientific community. Research into exercise and diet-related biomarkers aims to improve health, performance, and recovery in military personnel, athletes, and lay-persons. Exercise physiology research has identified individual biomarkers for assessing health, performance, and recovery during exercise training. However, there are few recommendations for biomarker panels for tracking changes in individuals participating in physical activity and exercise training programs...
July 19, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28737527/genitourinary-vascularized-composite-allotransplantation
#5
Ilse M Schol, Dicken S C Ko, Curtis L Cetrulo
PURPOSE OF REVIEW: Genitourinary vascularized allotransplantation (GUVCA) is gaining interest as a treatment option for patients with functional and aesthetic urogenital tissue loss. Only three cases have been done worldwide and research on the implementation and feasibility of this procedure is in an elementary state. RECENT FINDINGS: The psychosocial impact and ethical considerations with GUVCA are remote, particularly because of the intimate and personal nature of genital tissue...
July 22, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28736732/a-systematic-review-of-studies-of-web-portals-for-patients-with-diabetes-mellitus
#6
REVIEW
Steven S Coughlin, Lovoria B Williams, Christos Hatzigeorgiou
Patient web portals are password-protected online websites that offer patients 24-hour access to personal health information from anywhere with an Internet connection. Due to advances in health information technologies, there has been increasing interest among providers and researchers in patient web portals for use by patients with diabetes and other chronic conditions. This article, which is based upon bibliographic searches in PubMed, reviews web portals for patients with diabetes mellitus including patient web portals tethered to electronic medical records and web portals developed specifically for patients with diabetes...
2017: MHealth
https://www.readbyqxmd.com/read/28736627/personalized-and-precision-medicine-integrating-genomics-into-treatment-decisions-in-gastrointestinal-malignancies
#7
REVIEW
Trang H Au, Kai Wang, David Stenehjem, Ignacio Garrido-Laguna
The advent of next generation sequencing (NGS) technologies has advanced our understanding of the intrinsic biology of different gastrointestinal (GI) tumor types. The use of novel, more efficient sequencing platforms has improved turnaround times of sequencing results. This is providing real time opportunities to put precision medicine to the test. A number of early phase clinical trials are testing targeted therapies in unique molecularly characterized subsets of patients (baskets). While basket studies are gaining momentum, treatment failures serve to remind us that shifting from a histology-driven to a histology-agnostic approach is unlikely to be a failure-free strategy for a number of tumor types as recently learnt from vemurafenib failure in BRAF mutated metastatic colorectal cancer (mCRC)...
June 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28736271/b-cells-and-their-cytokine-activities-implications-in-human-diseases
#8
Simon Fillatreau
B cells are the only cell type that can give rise to antibody-producing cells, and the only cell type whose selective depletion can, today, lead to an improvement of a wide range of immune-mediated inflammatory diseases, including disorders not primarily driven by autoantibodies. Here, I discuss this paradoxical observation, and propose that the capacity of B cells to act as cytokine-producing cells explains how they can control monocyte activity and subsequently disease pathogenesis. Together with current data on the effect of anti-CD20 B cell-depleting reagents in the clinic, this novel knowledge on B cell heterogeneity opens the way for novel safer and more efficient strategies to target B cells...
July 20, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28736238/the-pursuit-of-therapeutic-biomarkers-with-high-throughput-cancer-cell-drug-screens
#9
REVIEW
Steven P Williams, Ultan McDermott
In the last decade we have witnessed tremendous advances in our understanding of the landscape of the molecular alterations that underpin many of the most prevalent cancers, in the use of automated high-throughput platforms for high-throughput drug screens in cancer cells, in the creation of more clinically relevant cancer cell models, and lastly in the development of more useful computational approaches in the pursuit of biomarkers of drug response. Separately, each of these improvements will undoubtedly lead to improvements in the treatment of cancer patients but to fulfill the promise of truly personalized cancer medicine, we must bring these disciplines together in a truly multidisciplinary fashion...
July 12, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28735528/lipids-evergreen-autofluorescent-biomarkers-for-the-liver-functional-profiling
#10
Anna Cleta Croce, Giovanni Bottiroli
Depending on their chemical nature, lipids can be classified in two main categories: hydrophilic, greatly contributing to membrane composition and subcellular organelle compartmentalization, and hydrophobic, mostly triglycerides, greatly enrolled in the storage and production of energy. In both cases, some lipid molecules can be involved as signaling agents in the regulation of metabolism and protective or damaging pathways in responses to harmful stimuli. These events could affect in particular the liver, because of its central role in the maintenance of lipid homeostasis...
June 1, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/28735467/outcomes-of-preexisting-diabetes-mellitus-in-breast-colorectal-and-prostate-cancer
#11
Robert I Griffiths, José M Valderas, Emily C McFadden, Clare R Bankhead, Bernadette A Lavery, Nada F Khan, Richard J Stevens, Nancy L Keating
PURPOSE: Preexisting diabetes is associated with increased morbidity and mortality in cancer. We examined the impact of incident cancer on the long-term outcomes of diabetes. METHODS: Using the United Kingdom Clinical Practice Research Datalink, we identified three cohorts of diabetes patients subsequently diagnosed with breast, colorectal, or prostate cancer, each matched to diabetic noncancer controls. Patients were required to have survived at least 1 year after cancer diagnosis (cases) or a matched index date (controls), and were followed up to 10 years for incident microvascular and macrovascular complications and mortality...
July 22, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28735466/comparative-metabolic-analysis-in-head-and-neck-cancer-and-the-normal-gingiva
#12
Nadine Fabienne Voelxen, Sebastian Blatt, Pascal Knopf, Maurice Henkel, Christina Appelhans, Leonardo A R Righesso, Andreas Pabst, Jutta Goldschmitt, Stefan Walenta, Andreas Neff, Wolfgang Mueller-Klieser, Thomas Ziebart
OBJECTIVES: Chronic accumulation of lactate in malignant tumor tissue is associated with increased malignancy and radioresistance. For this study, biopsies of primary head and neck squamous cell carcinoma (HNSCC) and of the normal gingiva of the same patient were compared via metabolic profiling to the healthy gingiva from cancer-free patients. MATERIALS AND METHODS: Cryobiopsies of 140 HNSCC patients were used to determine ATP, lactate, and glucose concentrations of the tumor and normal gingiva via induced metabolic bioluminescence imaging (imBI)...
July 22, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28735153/self-monitoring-systems-for-personalised-health-care-and-lifestyle-surveillance
#13
EDITORIAL
Giuseppe Coppini, Sara Colantonio
The quality of life and individual well-being are universally recognised as key factors in disease prevention. In particular, lifestyle interventions are effective tools for reducing the risk and incidence of major illnesses, such as cardiovascular diseases and metabolic disorders. On the other hand, patient role is progressively shifting from being a passive recipient of care towards being a co-producer of her/his health. In this frame, novel devices and systems able to help individuals in self-evaluation are expected to play a crucial role...
July 19, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28734901/gastroresistant-oral-peptide-for-fluorescence-imaging-of-colonic-inflammation
#14
Paola Luciani, Ander Estella-Hermoso de Mendoza, Tommaso Casalini, Silvia Lang, Kirstin Atrott, Marianne R Spalinger, Anna Pratsinis, Jens Sobek, Isabelle Frey-Wagner, Jens Schumacher, Jean-Christophe Leroux, Gerhard Rogler
The use of molecular markers for inflammation in the gastrointestinal tract could empower optical imaging modalities for early diagnosis and eventually personalized timely treatments. A major hurdle to the widespread use of functional fluorescence imaging is the absence of suitable contrast agents, in particular to be administered via the oral route due to the usual proteolytic susceptibility of the biomarkers. By designing a retro-inverso peptide, starting from a previously described sequence specific for N-cadherin, we achieved resistance to gastrointestinal degradation and even slightly improved specificity towards the target, both in ex vivo and in vivo experimental colitis...
July 19, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28734874/robotic-assistants-in-personal-care-a-scoping-review
#15
REVIEW
A Bilyea, N Seth, S Nesathurai, H A Abdullah
The aim of this study is to present an overview of the technological advances in the field of robotics developed for assistance with activities of daily living (ADL), and to present areas where further research is required. Four databases were searched for articles presenting either a novel design of one of these personal care robotic system or trial results relating to these systems. Articles presenting nine different robotic personal care systems were examined, six of which had been developed after 2005. These six also all have publications relating to their trials...
July 19, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28734864/reasons-for-seeking-clinical-care-for-lower-urinary-tract-symptoms-a-mixed-methods-study
#16
James W Griffith, Emily E Messersmith, Brenda W Gillespie, Jonathan B Wiseman, Kathryn E Flynn, Ziya Kirkali, John W Kusek, Tamara Bavendam, David Cella, Karl J Kreder, Jasmine J Nero, Maria E Corona, Catherine S Bradley, Kimberly S Kenton, Brian T Helfand, Robert M Merion, Kevin P Weinfurt
PURPOSE: The primary objective of this study was to evaluate reasons for seeking care among men and women with lower urinary tract symptoms (LUTS). METHODS: Participants were recruited from urology and urogynecology clinics, and the community. The sample was enriched with persons expected to have abnormal or diminished bladder sensations (e.g., participants with lower back surgery, participants aged 65+). In-person interviews were conducted, beginning with an open-ended assessment of urinary symptoms and associated bother, followed by more directed questions, including reasons for seeking or not seeking treatment...
July 19, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28734807/-a-survey-on-premedication-prior-to-intubation-in-very-preterm-infants-28-32wg-with-respiratory-distress-syndrome-in-french-neonatal-intensive-care-units
#17
E Boiron, E Merlot, G Loron, X Durrmeyer, E Guyot
INTRODUCTION/OBJECTIVES: Tracheal intubation is a painful procedure for which the routine use of analgesia is recommended. However, the use of premedication for intubation is not yet generalized and there is great diversity in the drugs used. The main objective of this study was to describe the frequency of premedication use in preterm neonates aged between 28 and 32weeks of gestation, intubated for respiratory distress syndrome. Secondary objectives were to describe the existence of a written protocol, its influence on the frequency of premedication and the drugs used...
July 19, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28734683/health-seeking-behavior-and-medical-facility-choice-in-samsun-turkey
#18
Cihad Dündar
OBJECTIVE: Examining the factors that play a role in determining patient preferences for different healthcare institutions. METHOD: This descriptive study was conducted in five family health centers (FHC) and in six hospitals in Samsun Province in Turkey. The data were collected from 1700 volunteer patients by using a structured questionnaire, while they were waiting for consultation. RESULT: The average number of out-patient visits was 9...
July 12, 2017: Health Policy
https://www.readbyqxmd.com/read/28734045/effectiveness-of-light-therapy-in-cognitively-impaired-persons-a-metaanalysis-of-randomized-controlled-trials
#19
Huei-Ling Chiu, Pi-Tuan Chen, Hsin Chu, Shu-Tai Sheen Hsiao, Doresses Liu, Chueh-Ho Lin, Kuei-Ru Chou
OBJECTIVES: To explore the effects of light therapy on behavioral disturbances (BDs), sleep quality, and depression. DESIGN: Meta-analysis of randomized controlled trials. SETTING: PubMed, Cochrane Library, Medline, EMBASE, Web of Science, and clinicaltrials.gov of selected randomized controlled trials and previous systematic reviews were searched. PARTICIPANTS: Cognitively impaired persons. MEASUREMENTS: Information was extracted on study characteristics, quality assessment, and outcomes...
July 22, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28733462/human-t-cell-immunosenescence-and-inflammation-in-aging
#20
REVIEW
Arsun Bektas, Shepherd H Schurman, Ranjan Sen, Luigi Ferrucci
The aging process is driven by a finite number of inter-related mechanisms that ultimately lead to the emergence of characteristic phenotypes, including increased susceptibility to multiple chronic diseases, disability, and death. New assays and analytical tools have become available that start to unravel some of these mechanisms. A prevailing view is that aging leads to an imbalance between stressors and stress-buffering mechanisms that causes loss of compensatory reserve and accumulation of unrepaired damage...
July 21, 2017: Journal of Leukocyte Biology
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