Anne Zaremba, Georg Lodde, Rajmohan Murali, Manuel Philip, Ioana Cosgarea, Philipp Jansen, Eleftheria Chorti, Christian Rose, Bernhard Hemmerlein, Johanna Matull, Carl M Thielmann, Julia Kretz, Inga Möller, Antje Sucker, Annette Paschen, Elisabeth Livingstone, Lisa Zimmer, Susanne Horn, Dirk Schadendorf, Eva Hadaschik, Klaus Griewank
Accurate classification of melanocytic proliferations has important implications for prognostic prediction, treatment and follow-up. Although most melanocytic proliferations can be accurately classified using clinical and pathological criteria, classification (specifically distinction between nevus and melanoma) can be challenging in a subset of cases, including those with spitzoid morphology. Genetic studies have shown that mutation profiles differ between primary melanoma subtypes and Spitz nevi. These differences may aid in distinguishing benign from malignant in some melanocytic tumours...
May 2021: European Journal of Cancer