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spitzoid nevus

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https://www.readbyqxmd.com/read/28528541/melanoma-frequency-among-symmetrical-spitzoid-looking-lesions-a-retrospective-study
#1
Claudia Costa, Matteo Megna, Milena Cappello, Maddalena Napolitano, Giuseppe Monfrecola, Massimiliano Scalvenzi
BACKGROUND: Many efforts have been spent attempting to define clinical, histopathological and molecular markers for differential diagnosis of Spitz nevus and melanoma. Dermoscopy has been widely used but it may be not always sufficient. METHODS: A retrospective study was performed evaluating Spitzoid-looking lesions showing symmetry at clinical and dermoscopic examination in patients ≥ 12 years attending our Clinic from 2004 to 2014. Demographic, clinical and dermoscopic data were assessed for each lesion in order to highlight the most common characteristics which could help the differential diagnosis between Spitz nevus and melanoma when clinical or dermoscopic asymmetry is lacking...
May 16, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28509525/melanoma-frequency-among-symmetrical-spitzoid-looking-lesions-a-retrospective-study
#2
Claudia Costa, Matteo Megna, Milena Cappello, Maddalena Napolitano, Giuseppe Monfrecola, Massimiliano Scalvenzi
BACKGROUND: Many efforts have been spent attempting to define clinical, histopathological and molecular markers for differential diagnosis of Spitz nevus and melanoma. Dermoscopy has been widely used but it may be not always sufficient. METHODS: A retrospective study was performed evaluating Spitzoid-looking lesions showing symmetry at clinical and dermoscopic examination in patients ≥ 12 years attending our Clinic from 2004 to 2014. Demographic, clinical and dermoscopic data were assessed for each lesion in order to highlight the most common characteristics which could help the differential diagnosis between Spitz nevus and melanoma when clinical or dermoscopic asymmetry is lacking...
May 16, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28475519/genomic-assessment-of-blitz-nevi-suggests-classification-as-a-subset-of-blue-nevus-rather-than-spitz-nevus-clinical-histopathologic-and-molecular-analysis-of-18-cases
#3
Maria C Isales, Alexandra M Haugh, Jeffrey Bubley, Anna E Verzì, Bin Zhang, Emily Kudalkar, Christina Y Lee, Pedram Yazdan, Joan Guitart, Pedram Gerami
Blitz nevi/tumors are a distinct subset of melanocytic neoplasia which show mixed morphologic features of Spitz and blue nevus. Genomically, most blue nevi have GNAQ or GNA11 mutations while most Spitzoid neoplasms have either an HRAS mutation or translocations involving MET, ROS, BRAF, ALK1, NTRK1, and RET. The criteria used for the assessment of malignancy in blue and Spitzoid lesions are different, and these lesions have different prognostic markers. In this study, we assess the clinical, morphological, and genomic changes in 18 cases of Blitz nevi/tumors to better characterize this subset of neoplasms and determine their optimal genomic classification...
April 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28407793/the-diagnosis-and-management-of-the-spitz-nevus-in-the-pediatric-population-a-systematic-review-and-meta-analysis%C3%A2-protocol
#4
Jean Abboud, Michael Stein, Michele Ramien, Claudia Malic
BACKGROUND: Spitz nevi are uncommon melanocytic neoplasms found in children. Historically, the diagnosis and management of these tumors has lacked consensus among oncologists, pathologists, plastic surgeons, and dermatologists. Once interpreted and treated as a "juvenile melanoma", many have argued for the benignancy of such tumors in certain patient age groups, encouraging a conservative approach. The lack of consensus surrounding the diagnosis and perceived malignant potential of these tumors has led physicians to approach them on a case-by-case basis and institutional protocols...
April 13, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28362709/a-diagnostic-algorithm-combining-immunohistochemistry-and-molecular-cytogenetics-to-diagnose-challenging-melanocytic-tumors
#5
Sylvia Redon, Briac Guibourg, Matthieu Talagas, Pascale Marcorelles, Arnaud Uguen
Some melanocytic tumors are diagnostic challenges and require ancillary tools in helping the pathologists to determine their potential of malignancy. We intend to propose a diagnostic algorithm in helping to classify challenging melanocytic tumors combining histology, immunohistochemistry, and cytogenetics. We report on 24 spitzoid and/or misdiagnosed melanocytic tumors studied with a triple p16, Ki-67, and HMB45 immunohistochemistry score, fluorescent in situ hybridization (FISH) with melanoma-dedicated and non-melanoma-dedicated probes and comparative genomic hybridization on DNA microarray (CGH array)...
March 30, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28102445/-congenital-nevus-atypical-spitz-nevus-or-spitzoid-melanoma
#6
A Blum, M Tanaka, K S Kraemer-Schultheiss, J Bauer
No abstract text is available yet for this article.
January 19, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27860221/spitz-nevi-diverse-clinical-dermatoscopic-and-histopathological-features-in-childhood
#7
Emi Dika, Iria Neri, Pier Alessandro Fanti, Alessia Barisani, Giulia Maria Ravaioli, Annalisa Patrizi
BACKGROUND AND OBJECTIVES: The characterization of clinical features and biological potential of Spitz nevi has attracted a lot of interest in past decades. The aim of our paper was to describe the clinical, dermatoscopic features as well as the clinical outcome of surgically excised Spitz nevi in three different pediatric age groups. PATIENTS AND METHODS: A retrospective study analyzing clinical features, videodermatoscopic images, histopathological diagnosis and patient outcome...
November 10, 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27222771/time-to-reconsider-spitzoid-neoplasms
#8
REVIEW
Carmelo Urso
BACKGROUND: Spitzoid neoplasms may pose significant diagnostic problems because in a fraction of them it is quite difficult or impossible to establish if they are benign or malignant lesions. An extraordinarily large number of studies have been made in attempts to solve this problem; regrettably, the histological criteria proposed and the various special sophisticated techniques employed have proven to be ineffective in making this distinction with confidence. OBJECTIVES: To explore the possible causes for this diagnostic failure and an attempt to identify the source of this problem...
April 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27173829/differential-diagnosis-of-spitzoid-melanocytic-neoplasms
#9
REVIEW
C Stefanaki, K Stefanaki, L Chardalias, E Soura, A Stratigos
Atypical Spitzoid neoplasms represent a controversial and incompletely defined diagnostic category for lesions with intermediate architecture and cytomorphology between Spitz nevus and melanoma. The vast majority of these neoplasms have a good overall prognosis. Only a small proportion of patients will end up developing distant metastases and death. The distinction between Spitz tumours with atypical features and Spitzoid melanoma remains difficult on clinical and histological grounds and the prediction of the biological behaviour of those tumours even with sentinel lymph node biopsy is impossible...
August 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27152444/immunohistochemical-evaluation-of-p16-expression-in-cutaneous-histiocytic-fibrohistiocytic-and-undifferentiated-lesions
#10
Emily H Smith, Lori Lowe, Paul W Harms, Douglas R Fullen, May P Chan
BACKGROUND: Expression of p16 is frequently evaluated in melanocytic lesions. Expression of p16 in cutaneous histiocytic, fibrohistiocytic and undifferentiated lesions has not been well characterized. METHODS: We evaluated p16 expression in a cohort of histiocytic (reticulohistiocytoma, Langerhans cell histiocytosis, xanthogranuloma, Rosai Dorfman disease and xanthoma), fibrohistiocytic (dermatofibroma, epithelioid fibrous histiocytoma and dermatofibrosarcoma protuberans) and undifferentiated (atypical fibroxanthoma and pleomorphic undifferentiated sarcoma) lesions...
August 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27102343/a-diagnostic-algorithm-for-atypical-spitzoid-tumors-guidelines-for-immunohistochemical-and-molecular-assessment
#11
Jeong Hee Cho-Vega
Atypical spitzoid tumors are a morphologically diverse group of rare melanocytic lesions most frequently seen in children and young adults. As atypical spitzoid tumors bear striking resemblance to Spitz nevus and spitzoid melanomas clinically and histopathologically, it is crucial to determine its malignant potential and predict its clinical behavior. To date, many researchers have attempted to differentiate atypical spitzoid tumors from unequivocal melanomas based on morphological, immonohistochemical, and molecular diagnostic differences...
July 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/26812275/unusual-dermoscopic-patterns-of-seborrheic-keratosis
#12
Lorenzo Squillace, Milena Cappello, Caterina Longo, Elvira Moscarella, Roberto Alfano, Giuseppe Argenziano
BACKGROUND: Seborrheic keratoses (SKs) may sometimes mimic benign and malignant skin tumors, and a biopsy can be necessary in order to rule out malignancy. METHODS: From the database of our pigmented lesion clinic, we evaluated the dermoscopic features of difficult-to-diagnose SKs that were biopsied between January 2010 and December 2014. RESULTS: SKs represented 3.8% of all excised lesions (161/ 4,182). Specifically, 91 (56.5%) were excised to rule out melanoma, 63 (39...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/26779311/simulants-of-malignant-melanoma
#13
REVIEW
Gérald E Piérard, Claudine Piérard-Franchimont, Philippe Delvenne
During the recent period, dermoscopy has yielded improvement in the early disclosure of various atypical melanocytic neoplasms (AMN) of the skin. Beyond this clinical procedure, AMN histopathology remains mandatory for establishing their precise diagnosis. Of note, panels of experts in AMN merely report moderate agreement in various puzzling cases. Divergences in opinion and misdiagnosis are likely increased when histopathological criteria are not fine-tuned and when facing a diversity of AMN types. Furthermore, some AMN have been differently named in the literature including atypical Spitz tumor, metastasizing Spitz tumor, borderline and intermediate melanocytic tumor, malignant Spitz nevus, pigmented epithelioid melanocytoma or animal-type melanoma...
February 10, 2015: Oncology Reviews
https://www.readbyqxmd.com/read/26498574/spitz-nevus-arising-in-the-eyelid-of-a-teenager
#14
REVIEW
Patrick W Shields, Frederick A Jakobiec, Anna M Stagner, Michael K Yoon
A 16-year-old boy developed over a 2-month interval a lightly pigmented left upper eyelid lesion measuring 1.5 mm in greatest diameter that, when excised, microscopically was hypercellular and composed almost exclusively of nonpigmented epithelioid cells that created florid, large intraepidermal junctional nests and sheets and nests of subepidermal cells. The diagnosis was a Spitz nevus. HMB-45, MART-1, and microphthalmia-associated transcription factor were all positive and established the melanocytic nature of the benign tumor...
March 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/26475536/clinical-and-dermoscopic-features-of-atypical-spitz-tumors-a-multicenter-retrospective-case-control-study
#15
MULTICENTER STUDY
Elvira Moscarella, Aimilios Lallas, Athanassios Kyrgidis, Gerardo Ferrara, Caterina Longo, Massimiliano Scalvenzi, Stefania Staibano, Cristina Carrera, M Alba Díaz, Paolo Broganelli, Carlo Tomasini, Stefano Cavicchini, Raffaele Gianotti, Susana Puig, Josep Malvehy, Pedro Zaballos, Giovanni Pellacani, Giuseppe Argenziano
BACKGROUND: Few studies have described the clinical and dermoscopic features of atypical Spitz tumors. OBJECTIVE: We sought to describe the clinical and dermoscopic features of a series of atypical Spitz tumors as compared with those of conventional Spitz nevi. METHODS: This was a multicenter, retrospective, case-control study, analyzing the clinical and dermoscopic characteristics of 55 atypical Spitz tumors and 110 Spitz nevi that were excised and diagnosed histopathologically...
November 2015: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/26414472/atypical-spitz-tumors-a-diagnostic-challenge
#16
REVIEW
Kelly L Harms, Lori Lowe, Douglas R Fullen, Paul W Harms
Spitzoid melanocytic lesions encompass a spectrum from benign Spitz nevi to malignant spitzoid melanomas. Spitzoid melanocytic neoplasms have significant morphologic and molecular differences from conventional melanocytic lesions, and prediction of biologic behavior and metastatic risk may be difficult. Most challenging is the atypical Spitz tumor, a borderline spitzoid melanocytic lesion of uncertain malignant potential that has overlapping histologic features with conventional Spitz nevus and spitzoid melanoma...
October 2015: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/26356543/morphologic-clues-and-utility-of-fluorescence-in-situ-hybridization-for-the-diagnosis-of-nevoid-melanoma
#17
Oriol Yélamos, Klaus J Busam, Christina Lee, Lauren Meldi Sholl, Sapna M Amin, Emily A Merkel, Roxana Obregon, Joan Guitart, Pedram Gerami
BACKGROUND: Nevoid melanomas include melanomas with a low power silhouette similar to melanocytic nevi. However, at higher power magnification, nevoid melanoma may have severe nuclear atypia and dermal mitoses. METHODS: We performed a clinical, pathological and molecular study on a series of 58 examples of nevoid melanoma, excluding cases with spitzoid morphology. RESULTS: We identified distinct morphologic patterns: 'classic' nevoid melanoma, superficial spreading melanomas with nevoid invasive melanoma, lentigo maligna with nevoid invasive melanoma and deep penetrating nevus-like nevoid melanoma...
November 2015: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/26061100/tert-promoter-mutations-are-predictive-of-aggressive-clinical-behavior-in-patients-with-spitzoid-melanocytic-neoplasms
#18
Seungjae Lee, Raymond L Barnhill, Reinhard Dummer, James Dalton, Jianrong Wu, Alberto Pappo, Armita Bahrami
Spitzoid neoplasms constitute a morphologically distinct category of melanocytic tumors, encompassing Spitz nevus (benign), atypical Spitz tumor (intermediate malignant potential), and spitzoid melanoma (fully malignant). Currently, no reliable histopathological criteria or molecular marker is known to distinguish borderline from overtly malignant neoplasms. Because TERT promoter (TERT-p) mutations are common in inherently aggressive cutaneous conventional melanoma, we sought to evaluate their prognostic significance in spitzoid neoplasms...
2015: Scientific Reports
https://www.readbyqxmd.com/read/25953246/bap1-deficient-and-ve1-negative-atypical-spitz-tumor
#19
Celia Requena, Virginia Sanz, Eduardo Nagore, Zaida García-Casado, Luis Rubio, Carlos Guillén, Heinz Kutzner
Atypical Spitz tumor with loss of BAP1 or Wiesner nevus is a peculiar variant of intradermal spitzoid melanocytic neoplasm composed of epithelioid melanocytes with a sheet-like growth pattern, abundant infiltrating lymphocytes and rare or absent mitotic activity. This subset of atypical spitzoid tumors is characterized by the BRAF(V600E) mutation and loss of BAP1 expression. Recognition of these lesions is important because they can be a marker for a hereditary BAP1-associated cancer syndrome. We present an unusual case of sporadic Wiesner nevus that had typical histopathologic features and a BAP1 but not a BRAF mutation...
August 2015: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/25943242/atypical-spitz-tumor-arising-on-a-congenital-linear-plaque-type-blue-nevus-a-case-report-with-a-review-of-the-literature-on-plaque-type-blue-nevus
#20
REVIEW
Franco Rongioletti, Antonio Guadagno, Caterina Campisi, Francesco Cabiddu, Heinz Kutzner, Aurora Parodi, Roberto Fiocca
The plaque-type blue nevus (PTBN) is a rare variant of blue nevus, of which only a few reports are described. A nodular growth within a preexistent PTBN should always alert to the possibility of malignant transformation. The authors report the first case of an atypical Spitz tumor arising on a congenital linear PTBN in a 60-year-old woman. The diagnosis of "atypical Spitz tumor" is here used to describe a microscopic "gray zone" in which it is not possible to differentiate with adequate certainty between a Spitz nevus and a spitzoid melanoma...
December 2015: American Journal of Dermatopathology
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