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spitzoid nevus

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https://www.readbyqxmd.com/read/27860221/spitz-nevi-diverse-clinical-dermatoscopic-and-histopathological-features-in-childhood
#1
Emi Dika, Iria Neri, Pier Alessandro Fanti, Alessia Barisani, Giulia Maria Ravaioli, Annalisa Patrizi
BACKGROUND AND OBJECTIVES: The characterization of clinical features and biological potential of Spitz nevi has attracted a lot of interest in past decades. The aim of our paper was to describe the clinical, dermatoscopic features as well as the clinical outcome of surgically excised Spitz nevi in three different pediatric age groups. PATIENTS AND METHODS: A retrospective study analyzing clinical features, videodermatoscopic images, histopathological diagnosis and patient outcome...
November 10, 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27222771/time-to-reconsider-spitzoid-neoplasms
#2
REVIEW
Carmelo Urso
BACKGROUND: Spitzoid neoplasms may pose significant diagnostic problems because in a fraction of them it is quite difficult or impossible to establish if they are benign or malignant lesions. An extraordinarily large number of studies have been made in attempts to solve this problem; regrettably, the histological criteria proposed and the various special sophisticated techniques employed have proven to be ineffective in making this distinction with confidence. OBJECTIVES: To explore the possible causes for this diagnostic failure and an attempt to identify the source of this problem...
April 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27173829/differential-diagnosis-of-spitzoid-melanocytic-neoplasms
#3
REVIEW
C Stefanaki, K Stefanaki, L Chardalias, E Soura, A Stratigos
Atypical Spitzoid neoplasms represent a controversial and incompletely defined diagnostic category for lesions with intermediate architecture and cytomorphology between Spitz nevus and melanoma. The vast majority of these neoplasms have a good overall prognosis. Only a small proportion of patients will end up developing distant metastases and death. The distinction between Spitz tumours with atypical features and Spitzoid melanoma remains difficult on clinical and histological grounds and the prediction of the biological behaviour of those tumours even with sentinel lymph node biopsy is impossible...
August 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27152444/immunohistochemical-evaluation-of-p16-expression-in-cutaneous-histiocytic-fibrohistiocytic-and-undifferentiated-lesions
#4
Emily H Smith, Lori Lowe, Paul W Harms, Douglas R Fullen, May P Chan
BACKGROUND: Expression of p16 is frequently evaluated in melanocytic lesions. Expression of p16 in cutaneous histiocytic, fibrohistiocytic and undifferentiated lesions has not been well characterized. METHODS: We evaluated p16 expression in a cohort of histiocytic (reticulohistiocytoma, Langerhans cell histiocytosis, xanthogranuloma, Rosai Dorfman disease and xanthoma), fibrohistiocytic (dermatofibroma, epithelioid fibrous histiocytoma and dermatofibrosarcoma protuberans) and undifferentiated (atypical fibroxanthoma and pleomorphic undifferentiated sarcoma) lesions...
August 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27102343/a-diagnostic-algorithm-for-atypical-spitzoid-tumors-guidelines-for-immunohistochemical-and-molecular-assessment
#5
Jeong Hee Cho-Vega
Atypical spitzoid tumors are a morphologically diverse group of rare melanocytic lesions most frequently seen in children and young adults. As atypical spitzoid tumors bear striking resemblance to Spitz nevus and spitzoid melanomas clinically and histopathologically, it is crucial to determine its malignant potential and predict its clinical behavior. To date, many researchers have attempted to differentiate atypical spitzoid tumors from unequivocal melanomas based on morphological, immonohistochemical, and molecular diagnostic differences...
July 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/26812275/unusual-dermoscopic-patterns-of-seborrheic-keratosis
#6
Lorenzo Squillace, Milena Cappello, Caterina Longo, Elvira Moscarella, Roberto Alfano, Giuseppe Argenziano
BACKGROUND: Seborrheic keratoses (SKs) may sometimes mimic benign and malignant skin tumors, and a biopsy can be necessary in order to rule out malignancy. METHODS: From the database of our pigmented lesion clinic, we evaluated the dermoscopic features of difficult-to-diagnose SKs that were biopsied between January 2010 and December 2014. RESULTS: SKs represented 3.8% of all excised lesions (161/ 4,182). Specifically, 91 (56.5%) were excised to rule out melanoma, 63 (39...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/26779311/simulants-of-malignant-melanoma
#7
REVIEW
Gérald E Piérard, Claudine Piérard-Franchimont, Philippe Delvenne
During the recent period, dermoscopy has yielded improvement in the early disclosure of various atypical melanocytic neoplasms (AMN) of the skin. Beyond this clinical procedure, AMN histopathology remains mandatory for establishing their precise diagnosis. Of note, panels of experts in AMN merely report moderate agreement in various puzzling cases. Divergences in opinion and misdiagnosis are likely increased when histopathological criteria are not fine-tuned and when facing a diversity of AMN types. Furthermore, some AMN have been differently named in the literature including atypical Spitz tumor, metastasizing Spitz tumor, borderline and intermediate melanocytic tumor, malignant Spitz nevus, pigmented epithelioid melanocytoma or animal-type melanoma...
February 10, 2015: Oncology Reviews
https://www.readbyqxmd.com/read/26498574/spitz-nevus-arising-in-the-eyelid-of-a-teenager
#8
REVIEW
Patrick W Shields, Frederick A Jakobiec, Anna M Stagner, Michael K Yoon
A 16-year-old boy developed over a 2-month interval a lightly pigmented left upper eyelid lesion measuring 1.5 mm in greatest diameter that, when excised, microscopically was hypercellular and composed almost exclusively of nonpigmented epithelioid cells that created florid, large intraepidermal junctional nests and sheets and nests of subepidermal cells. The diagnosis was a Spitz nevus. HMB-45, MART-1, and microphthalmia-associated transcription factor were all positive and established the melanocytic nature of the benign tumor...
March 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/26475536/clinical-and-dermoscopic-features-of-atypical-spitz-tumors-a-multicenter-retrospective-case-control-study
#9
MULTICENTER STUDY
Elvira Moscarella, Aimilios Lallas, Athanassios Kyrgidis, Gerardo Ferrara, Caterina Longo, Massimiliano Scalvenzi, Stefania Staibano, Cristina Carrera, M Alba Díaz, Paolo Broganelli, Carlo Tomasini, Stefano Cavicchini, Raffaele Gianotti, Susana Puig, Josep Malvehy, Pedro Zaballos, Giovanni Pellacani, Giuseppe Argenziano
BACKGROUND: Few studies have described the clinical and dermoscopic features of atypical Spitz tumors. OBJECTIVE: We sought to describe the clinical and dermoscopic features of a series of atypical Spitz tumors as compared with those of conventional Spitz nevi. METHODS: This was a multicenter, retrospective, case-control study, analyzing the clinical and dermoscopic characteristics of 55 atypical Spitz tumors and 110 Spitz nevi that were excised and diagnosed histopathologically...
November 2015: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/26414472/atypical-spitz-tumors-a-diagnostic-challenge
#10
REVIEW
Kelly L Harms, Lori Lowe, Douglas R Fullen, Paul W Harms
Spitzoid melanocytic lesions encompass a spectrum from benign Spitz nevi to malignant spitzoid melanomas. Spitzoid melanocytic neoplasms have significant morphologic and molecular differences from conventional melanocytic lesions, and prediction of biologic behavior and metastatic risk may be difficult. Most challenging is the atypical Spitz tumor, a borderline spitzoid melanocytic lesion of uncertain malignant potential that has overlapping histologic features with conventional Spitz nevus and spitzoid melanoma...
October 2015: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/26356543/morphologic-clues-and-utility-of-fluorescence-in-situ-hybridization-for-the-diagnosis-of-nevoid-melanoma
#11
Oriol Yélamos, Klaus J Busam, Christina Lee, Lauren Meldi Sholl, Sapna M Amin, Emily A Merkel, Roxana Obregon, Joan Guitart, Pedram Gerami
BACKGROUND: Nevoid melanomas include melanomas with a low power silhouette similar to melanocytic nevi. However, at higher power magnification, nevoid melanoma may have severe nuclear atypia and dermal mitoses. METHODS: We performed a clinical, pathological and molecular study on a series of 58 examples of nevoid melanoma, excluding cases with spitzoid morphology. RESULTS: We identified distinct morphologic patterns: 'classic' nevoid melanoma, superficial spreading melanomas with nevoid invasive melanoma, lentigo maligna with nevoid invasive melanoma and deep penetrating nevus-like nevoid melanoma...
November 2015: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/26061100/tert-promoter-mutations-are-predictive-of-aggressive-clinical-behavior-in-patients-with-spitzoid-melanocytic-neoplasms
#12
Seungjae Lee, Raymond L Barnhill, Reinhard Dummer, James Dalton, Jianrong Wu, Alberto Pappo, Armita Bahrami
Spitzoid neoplasms constitute a morphologically distinct category of melanocytic tumors, encompassing Spitz nevus (benign), atypical Spitz tumor (intermediate malignant potential), and spitzoid melanoma (fully malignant). Currently, no reliable histopathological criteria or molecular marker is known to distinguish borderline from overtly malignant neoplasms. Because TERT promoter (TERT-p) mutations are common in inherently aggressive cutaneous conventional melanoma, we sought to evaluate their prognostic significance in spitzoid neoplasms...
2015: Scientific Reports
https://www.readbyqxmd.com/read/25953246/bap1-deficient-and-ve1-negative-atypical-spitz-tumor
#13
Celia Requena, Virginia Sanz, Eduardo Nagore, Zaida García-Casado, Luis Rubio, Carlos Guillén, Heinz Kutzner
Atypical Spitz tumor with loss of BAP1 or Wiesner nevus is a peculiar variant of intradermal spitzoid melanocytic neoplasm composed of epithelioid melanocytes with a sheet-like growth pattern, abundant infiltrating lymphocytes and rare or absent mitotic activity. This subset of atypical spitzoid tumors is characterized by the BRAF(V600E) mutation and loss of BAP1 expression. Recognition of these lesions is important because they can be a marker for a hereditary BAP1-associated cancer syndrome. We present an unusual case of sporadic Wiesner nevus that had typical histopathologic features and a BAP1 but not a BRAF mutation...
August 2015: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/25943242/atypical-spitz-tumor-arising-on-a-congenital-linear-plaque-type-blue-nevus-a-case-report-with-a-review-of-the-literature-on-plaque-type-blue-nevus
#14
REVIEW
Franco Rongioletti, Antonio Guadagno, Caterina Campisi, Francesco Cabiddu, Heinz Kutzner, Aurora Parodi, Roberto Fiocca
The plaque-type blue nevus (PTBN) is a rare variant of blue nevus, of which only a few reports are described. A nodular growth within a preexistent PTBN should always alert to the possibility of malignant transformation. The authors report the first case of an atypical Spitz tumor arising on a congenital linear PTBN in a 60-year-old woman. The diagnosis of "atypical Spitz tumor" is here used to describe a microscopic "gray zone" in which it is not possible to differentiate with adequate certainty between a Spitz nevus and a spitzoid melanoma...
December 2015: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/25902915/histomorphologic-spectrum-of-bap1-negative-melanocytic-neoplasms-in-a-family-with-bap1-associated-cancer-susceptibility-syndrome
#15
Zlatko Marušić, Marija Buljan, Klaus J Busam
BACKGROUND: Multiple BAP1 negative melanocytic neoplasms are a hallmark of familial cancer susceptibility syndrome caused by BAP1 germline mutation. The syndrome is characterized by increased incidence of renal cell carcinoma, mesothelioma, cholangiocarcinoma, cutaneous and uveal melanoma and some other neoplasms. METHODS: We report histomorphologic characteristics of six cutaneous melanocytic neoplasms with loss of BAP1 expression in two members of a family with BAP1-associated cancer susceptibility syndrome...
June 2015: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/25834363/a-case-of-spitzoid-melanoma
#16
Heung Yeol Kim, Jong Hyun Yoon, Eun Byul Cho, Eun Ju Park, Kwang Ho Kim, Kwang Joong Kim
Spitzoid melanoma is a subtype of melanoma that, clinically and histologically, resembles a Spitz nevus. Clinically, spitzoid melanomas usually evolve from amelanotic nodular lesions, growing to 1 cm or more in diameter. They often remain clinically undiagnosed because of their wide variety of clinical appearances and a lack of pigmentation. Distinguishing a Spitz nevus from a spitzoid melanoma can be extremely difficult. Features that favor the diagnosis of a spitzoid melanoma are asymmetrical shape, diameter greater than 1 cm, a lesion with a deep invasive component, and a high degree of cytologic atypia...
April 2015: Annals of Dermatology
https://www.readbyqxmd.com/read/25666674/unfolding-the-mutational-landscape-of-human-melanoma
#17
COMMENT
Diwakar Davar, Yan Lin, John M Kirkwood
Over the preceding two decades, sophisticated sequencing techniques have been used to characterize the genetic drivers of adult melanoma. However, our understanding of pediatric melanomas is still rudimentary. In this report, we comment on a thorough multi-platform analysis of common pediatric melanoma subsets, including pediatric conventional melanoma (CM), congenital nevus-derived melanoma (CNM), and Spitzoid melanoma (SM), contributed by Lu et al.
March 2015: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/25666330/ftir-microspectroscopic-characterization-of-spitz-nevi
#18
Elisabetta Giorgini, Giorgio Tosi, Carla Conti, Stefania Staibano, Gennaro Ilardi, Simona Sabbatini
In the last 10 years, few efforts have been carried out to apply vibrational spectroscopy in the study of dermal pathologies in order to characterize the most relevant spectral markers for distinguishing benign from cancerous lesions. Spitz nevi are a special group of benign melanocytic lesions, characterized by spindled and/or epithelioid nevomelanocytes, with peculiar clinical, dermoscopic and histopathological features. The "atypical forms" of Spitz nevi are among the commonest problems of differential diagnosis with the so-called "spitzoid melanomas"...
April 15, 2015: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/25661066/lymph-node-melanocytic-nevi-pathogenesis-and-differential-diagnoses-with-special-reference-to-p16-reactivity
#19
Simonetta Piana, Elena Tagliavini, Moira Ragazzi, Magda Zanelli, Iris Zalaudek, Alessia Ciarrocchi, Riccardo Valli
Lymph node nevi (NN) have been occasionally described, yet little is currently known on their origin. According to a theoretical model of nevogenesis, the dissemination of nevus progenitor cells through lymphatic routes is responsible for the development of both nodal and skin nevi. The true incidence of NN is largely unknown but it has been reported to vary from 0.017% to as high as 22%. The frequency of NN nevi has increased since the introduction of sentinel lymph node mapping as a routine prognostic procedure in breast cancer and melanoma...
May 2015: Pathology, Research and Practice
https://www.readbyqxmd.com/read/25613920/-morphological-and-genetic-aspects-of-spitz-tumors
#20
REVIEW
T Wiesner, H Kutzner
BACKGROUND: Spitzoid melanocytic neoplasms (i.e. Spitz nevi, atypical Spitz tumors and spitzoid melanoma) are a clinical, histopathological and molecular genetic heterogeneous group of melanocytic skin tumors. OBJECTIVES: Correlation of the histological features of spitzoid neoplasms with molecular genetic aberrations. MATERIAL AND METHODS: A review and summary of the scientific literature. RESULTS: Several histopathological and molecular genetic distinct subtypes of spitzoid lesions have been defined...
February 2015: Der Pathologe
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