Wei He, Chengcheng Xu, Yuying Huang, Qiuzhen Zhang, Wang Chen, Chengkuan Zhao, Yun Chen, Danling Zheng, XinyueLin, Qianhua Luo, Xiaoshan Chen, Zhihan Zhang, Xiaolong Wu, Jianxiang Huang, Chaoxian Lin, Yihui Huang, Shuyao Zhang
This study investigates the molecular mechanisms by which extracellular vesicles (EVs) derived from adipose-derived mesenchymal stem cells (ADSCs) promote M2 polarization of macrophages and thus reduce lung injury caused by sepsis. High-throughput sequencing was used to identify differentially expressed genes related to long non-coding RNA (lncRNA) in ADSC-derived EVs (ADSC-EVs) in sepsis lung tissue. Weighted gene co-expression network analysis (WGCNA) was employed to predict the downstream target genes of the lncRNA DLEU2...
March 4, 2024: International Immunopharmacology