keyword
https://read.qxmd.com/read/38447976/autologous-transplantation-of-green-tea-epigallocatechin-3-gallate-pretreated-adipose-derived-stem-cells-increases-cardiac-regenerative-capability-through-c-x-c-motif-chemokine-receptor-4-expression-in-the-treatment-of-rats-with-diabetic-cardiomyopathy
#21
JOURNAL ARTICLE
Tung-Sheng Chen, Wei-Wen Kuo, Chih-Yang Huang
Cardiomyopathy is one of complications related to diabetes. Stem cell transplantation shows potential in diabetic cardiomyopathy treatment. Epigallocatechin-3-gallate (EGCG) is one of the major components found in green tea. Although stem cell transplantation and green tea EGCG supplementation show therapeutic effects on cardiomyopathy, the detailed cellular mechanisms in stem cell transplantation coupled with EGCG treatment remain unclear. This study investigates whether adipose-derived stem cells (ADSC) pretreated with EGCG show better protective effect on diabetic cardiomyopathy than ADSC without EGCG pretreatment...
March 7, 2024: Experimental Animals
https://read.qxmd.com/read/38442573/therapeutic-potential-of-adsc-ev-derived-lncrna-dleu2-a-novel-molecular-pathway-in-alleviating-sepsis-induced-lung-injury-via-the-mir-106a-5p-lxn-axis
#22
JOURNAL ARTICLE
Wei He, Chengcheng Xu, Yuying Huang, Qiuzhen Zhang, Wang Chen, Chengkuan Zhao, Yun Chen, Danling Zheng, XinyueLin, Qianhua Luo, Xiaoshan Chen, Zhihan Zhang, Xiaolong Wu, Jianxiang Huang, Chaoxian Lin, Yihui Huang, Shuyao Zhang
This study investigates the molecular mechanisms by which extracellular vesicles (EVs) derived from adipose-derived mesenchymal stem cells (ADSCs) promote M2 polarization of macrophages and thus reduce lung injury caused by sepsis. High-throughput sequencing was used to identify differentially expressed genes related to long non-coding RNA (lncRNA) in ADSC-derived EVs (ADSC-EVs) in sepsis lung tissue. Weighted gene co-expression network analysis (WGCNA) was employed to predict the downstream target genes of the lncRNA DLEU2...
March 4, 2024: International Immunopharmacology
https://read.qxmd.com/read/38440324/bioinspired-engineering-adsc-nanovesicles-thermosensitive-hydrogel-enhance-autophagy-of-dermal-papilla-cells-for-androgenetic-alopecia-treatment
#23
JOURNAL ARTICLE
Jiachao Xiong, Zhixiao Liu, Lingling Jia, Yulin Sun, Rong Guo, Tingting Xi, Zihan Li, Minjuan Wu, Hua Jiang, Yufei Li
Androgenic alopecia (AGA) is a highly prevalent form of non-scarring alopecia but lacks effective treatments. Stem cell exosomes have similar repair effects to stem cells, suffer from the drawbacks of high cost and low yield yet. Cell-derived nanovesicles acquired through mechanical extrusion exhibit favorable biomimetic properties similar to exosomes, enabling them to efficiently encapsulate substantial quantities of therapeutic proteins. In this study, we observed that JAM-A, an adhesion protein, resulted in a significantly increased the adhesion and resilience of dermal papilla cells to form snap structures against damage caused by dihydrotestosterone and macrophages, thereby facilitating the process of hair regrowth in cases of AGA...
June 2024: Bioactive Materials
https://read.qxmd.com/read/38438760/the-mechanisms-of-adipose-stem-cell-derived-exosomes-promote-wound-healing-and-regeneration
#24
REVIEW
Zhengjie Lin, Danyi Lin, Dane Lin
Chronic wound healing is a class of diseases influenced by multiple complex factors, causing severe psychological and physiological impact on patients. It is an intractable clinical challenge and its possible mechanisms are not yet clear. It has been proven that adipose stem cell-derived exosomes (ADSC-Exos) can promote wound healing and inhibit scar formation by regulating inflammation, promoting cell proliferation, migration, and angiogenesis, regulating matrix remodeling, which provides a new approach for wound healing through biological treatment...
March 4, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38438053/adipose-tissue-derived-stem-cells-in-vivo-and-in-vitro-models-for-metabolic-diseases
#25
REVIEW
Jaime Navarro-Perez, Stefania Carobbio
The primary role of adipose tissue stem cells (ADSCs) is to support the function and homeostasis of adipose tissue in physiological and pathophysiological conditions. However, when ADSCs become dysfunctional in diseases such as obesity and cancer, they become impaired, undergo signalling changes, and their epigenome is altered, which can have a dramatic effect on human health. In more recent years, the therapeutic potential of ADSCs in regenerative medicine, wound healing, and for treating conditions such as cancer and metabolic diseases has been extensively investigated with very promising results...
March 2, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38434722/adipose-mesenchymal-stem-cell-derived-exosomes-promote-skin-wound-healing-in-diabetic-mice-by-regulating-epidermal-autophagy
#26
JOURNAL ARTICLE
Zhe Wang, Haiyue Ren, Peng Su, Feng Zhao, Qiqi Zhang, Xing Huang, Cai He, Quan Wu, Zitong Wang, Jiajie Ma
BACKGROUND: Adipose mesenchymal stem cell-derived exosomes (ADSC-Exos) have great potential in the field of tissue repair and regenerative medicine, particularly in cases of refractory diabetic wounds. Interestingly, autophagy plays a role in wound healing, and recent research has demonstrated that exosomes are closely associated with intracellular autophagy in biogenesis and molecular signaling mechanisms. Therefore, this study aimed to investigate whether ADSC-Exos promote the repair of diabetic wounds by regulating autophagy to provide a new method and theoretical basis for the treatment of diabetic wounds...
2024: Burns and Trauma
https://read.qxmd.com/read/38429909/adipose-stem-cell-derived-exosomes-promote-wound-healing-by-regulating-the-let-7i-5p-gas7-axis
#27
JOURNAL ARTICLE
Xiaosong Liu, Biao Wang
BACKGROUND: Injury to skin tissue is devastating for human health, making it imperative to devise strategies for hastening wound healing. Normal wound healing is a complex process comprising overlapping steps, including hemostasis, inflammatory response, proliferation, and matrix remodeling. This study investigated the effects of adipose stem cell-derived exosomes (ADSC-exos) on wound healing and the underlying mechanisms. METHODS: In vitro hydrogen peroxide (H2 O2 )-treated human keratinocyte (HaCaT) cell lines and in vivo animal wound models were established for this purpose...
March 1, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38428725/-evaluation-of-neprilysin-activity-in-adipose-derived-stem-cells-from-alzheimer-s-disease-patients
#28
JOURNAL ARTICLE
Kazuo Shigematsu, Naoyuki Komori, Mitsuko Ideno, Hisakazu Yamagishi
INTRODUCTION: The antibody drugs targeting β-amyloid in Alzheimer's disease pose risks of inflammation and vascular damage. It is known that neprilysin, an endogenous enzyme responsible for β-amyloid degradation, is reduced in areas with β-amyloid deposition. Supplementation of neprilysin could potentially contribute to Alzheimer's disease treatment. When considering the use of adipose tissue-derived stem cells (ADSCs) for Alzheimer's disease therapy, it is crucial to ensure that Alzheimer's disease patient-derived ADSCs maintain neprilysin activity...
February 28, 2024: Neuroscience Letters
https://read.qxmd.com/read/38425992/inhibition-of-pten-promotes-osteointegration-of-titanium-implants-in-type-2-diabetes-by-enhancing-anti-inflammation-and-osteogenic-capacity-of-adipose-derived-stem-cells
#29
JOURNAL ARTICLE
Guanhua Zhang, Shuang Song, Zijun Chen, Xiangdong Liu, Jian Zheng, Yuxi Wang, Xutao Chen, Yingliang Song
Background: The low osteogenic differentiation potential and attenuated anti-inflammatory effect of adipose-derived stem cells (ADSCs) from animals with type 2 diabetes mellitus (T2DM) limits osseointegration of the implant. However, the underlying mechanisms are not fully understood. Methods: Western blotting and qRT-PCR analyses were performed to investigate the effects of PTEN on the osteogenic capacity of ADSCs of T2DM rats (TADSCs). We conducted animal experiments in T2DM-Sprague Dawley (SD) rats to evaluate the osteogenic capacity of modified TADSC sheets in vivo ...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38420820/the-use-of-human-platelet-lysate-as-a-coating-substance-for-adipose-derived-stem-cell-expansion
#30
JOURNAL ARTICLE
Patcharapa Tragoonlugkana, Narong Chitchongyingcharoen, Chatchai Pruksapong, Shirmeela Hassan, Kamolchanok Ngamkham, Witchayapon Kamprom, Aungkura Supokawej
BACKGROUND: Large-scale production of mesenchymal stromal cells is essential for sufficient therapeutic doses in regenerative medicine. However, long-term cultivation encounters limited cell growth and cellular aging. Therefore, an alternative cell culture approach that promotes proliferation and attenuates cell senescence is required. Human platelet lysate (HPL) is a potent supplement for in vitro cell expansion. Applying HPL as a coating material can potentially improve mesenchymal stromal cell cultures...
February 23, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38418103/investigation-of-expanded-human-adipose-derived-stem-cell-dosage-and-timing-for-improved-defecation-function
#31
JOURNAL ARTICLE
Ryota Mori, Norikatsu Miyoshi, Shiki Fujino, Tsunekazu Mizushima, Ryohei Yukimoto, Takayuki Ogino, Hidekazu Takahashi, Mamoru Uemura, Yuichiro Doki, Hidetoshi Eguchi
BACKGROUND/AIM: Although certain treatment options exist for intestinal incontinence, none are curative. Adipose-derived stem cells (ADSCs) have emerged as promising therapeutic agents, but most preclinical studies of their effectiveness for anal function have used autologous or allogeneic ADSCs. In this study, the effectiveness, timing of administration, and required dosage of human ADSCs were investigated for clinical application. MATERIALS AND METHODS: A 10-mm balloon catheter was used to induce anal sphincter injury in immunodeficient mice in the following experimental groups (n=4 per group): ADSC (injected ADSCs after injury), PBS (injected phosphate-buffered saline after injury), and control (uninjured)...
2024: In Vivo
https://read.qxmd.com/read/38417670/heterogeneity-of-mesenchymal-stem-cells-as-a-limiting-factor-in-their-clinical-application-to-inflammatory-bowel-disease-in-dogs-and-cats
#32
REVIEW
Takahiro Teshima
Inflammatory bowel disease (IBD) is a major subtype of chronic enteropathies in dogs and cats. Conventional drugs such as immunomodulatory medicines as glucocorticoids and/or other anti-inflammatory are mainly applied for treatment. However, these drugs are not always effective to maintain remission from IBD and are limited by unacceptable side effects. Hence, more effective and safe therapeutic options need to be developed. Mesenchymal stem cells (MSCs) are multipotent stem cells with a self-renewal capacity, and have immunomodulatory, anti-inflammatory, anti-fibrotic, and tissue repair properties...
February 26, 2024: Veterinary Journal
https://read.qxmd.com/read/38413446/exploring-preclinical-experiments-with-different-fat-types-for-autologous-fat-grafting
#33
JOURNAL ARTICLE
Yixi Yu, Huabin Zhang, Zefan Sun, Shun Wang, Xiangbin Zhao, Bingkun Zhao, Aijun Zhang
BACKGROUND: Autologous fat transplantation has been a cornerstone of tissue regeneration for decades. However, there is no standardized selection system or criteria for fat graft selection, often relying heavily on the surgeon's experience. OBJECTIVES: This study aimed to investigate various types of fat derivatives, both in vitro and in vivo at the same condition. METHODS: We collected traditional fat granules of different sizes and SVF-gel, evaluating the viability of ADSCs isolated from them and their performance after grafting into mice...
February 27, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38411945/exosomes-from-adipose-derived-stem-cells-activate-sebocytes-through-the-pi3k-akt-srebp-1-pathway-to-accelerate-wound-healing
#34
JOURNAL ARTICLE
Yingbo Zhang, Christos C Zouboulis, Zhibo Xiao
Sebocyte regeneration after injury is considered a key element of functional skin repair. Exosomes from adipose-derived stem cells (ADSCs-EXO) accelerate wound healing by promoting the proliferation of fibroblasts. However, the effects of ADSCs-EXO on sebocytes are largely unknown. In this study, the effects of ADSCs-EXO on sebocyte proliferation and migration were evaluated. The levels of phosphorylated AKT (p-AKT), AKT, sterol regulatory-element binding protein (SREBP), and perilipin-1 (PLIN-1) were detected with immunofluorescence, quantitative PCR, and western blot analysis...
February 27, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38410163/one-step-stromal-vascular-fraction-therapy-in-osteoarthritis-with-tropoelastin-enhanced-autologous-stromal-vascular-fraction-gel
#35
JOURNAL ARTICLE
Junjun Yang, Xin Wang, XueBao Zeng, Rong Wang, Yanming Ma, Zhenlan Fu, Zu Wan, Zhi Wang, Liu Yang, Guangxing Chen, Xiaoyuan Gong
Background: Osteoarthritis (OA) is a debilitating degenerative joint disease, leading to significant pain and disability. Despite advancements, current regenerative therapies, such as mesenchymal stem cells (MSCs), face challenges in clinical efficacy and ethical considerations. This study aimed to evaluate the therapeutic potential of stromal vascular fraction gel (SVF-gel) in comparison to available treatments like hyaluronic acid (HA) and adipose-derived stem cells (ADSCs) and to assess the enhancement of this potential by incorporating tropoelastin (TE)...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38409346/in-vitro-study-of-thymosin-beta-4-promoting-transplanted-fat-survival-by-regulating-adipose-derived-stem-cells
#36
JOURNAL ARTICLE
Wandi Li, Yan Yang, Yan Lin, Dali Mu
BACKGROUND: Autologous fat grafting (AFG) has emerged as a highly sought-after plastic surgery procedure, although its success has been hampered by the uncertain fat survival rate. Current evidence suggests that adipose-derived stem cells (ADSCs) may contribute to fat retention in AFG. In previous studies, it was confirmed that thymosin beta 4 (Tβ4) could enhance fat survival in vivo, although the precise mechanism remains unclear. METHODS: ADSCs were isolated from patients undergoing liposuction and their proliferation, apoptosis, anti-apoptosis, and migration were analyzed under Tβ4 stimulation using cell counting kit-8, flow cytometry, wound healing assay, and real-time quantitative PCR...
February 26, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38399509/analyzing-the-clinical-potential-of-stromal-vascular-fraction-a-comprehensive-literature-review
#37
REVIEW
Evgeniy Nikolaevich Goncharov, Oleg Aleksandrovich Koval, Eremin Ilya Igorevich, Manuel De Jesus Encarnacion Ramirez, Renat Nurmukhametov, Kotenko Konstantin Valentinovich, Nicola Montemurro
Background: Regenerative medicine is evolving with discoveries like the stromal vascular fraction (SVF), a diverse cell group from adipose tissue with therapeutic promise. Originating from fat cell metabolism studies in the 1960s, SVF's versatility was recognized after demonstrating multipotency. Comprising of cells like pericytes, smooth muscle cells, and, notably, adipose-derived stem cells (ADSCs), SVF offers tissue regeneration and repair through the differentiation and secretion of growth factors. Its therapeutic efficacy is due to these cells' synergistic action, prompting extensive research...
January 27, 2024: Medicina
https://read.qxmd.com/read/38397032/adipose-derived-stem-cells-angiogenetic-potential-and-utility-in-tissue-engineering
#38
REVIEW
Felor Biniazan, Alina Stoian, Siba Haykal
Adipose tissue (AT) is a large and important energy storage organ as well as an endocrine organ with a critical role in many processes. Additionally, AT is an enormous and easily accessible source of multipotent cell types used in our day for all types of tissue regeneration. The ability of adipose-derived stem cells (ADSCs) to differentiate into other types of cells, such as endothelial cells (ECs), vascular smooth muscle cells, or cardiomyocytes, is used in tissue engineering in order to promote/stimulate the process of angiogenesis...
February 16, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38393667/exosomes-derived-from-adipose-stem-cells-enhance-angiogenesis-in-diabetic-wound-via-mir-146a-5p-jazf1-axis
#39
JOURNAL ARTICLE
Dehui Che, Xinjian Xiang, Juan Xie, Zenghong Chen, Qiong Bao, Dongsheng Cao
Chronic trauma in diabetes is a leading cause of disability and mortality. Exosomes show promise in tissue regeneration. This study investigates the role of exosomes derived from adipose stem cells (ADSC-Exos) in angiogenesis. MiRNA-seq analysis revealed significant changes in 47 genes in human umbilical vein endothelial cells (HUVECs) treated with ADSC-Exos, with miR-146a-5p highly expressed. MiR-146a-5p mimics enhanced the pro-angiogenic effects of ADSC-Exos, while inhibitors had the opposite effect. JAZF1 was identified as a direct downstream target of miR-146a-5p through bioinformatics, qRT-PCR, and dual luciferase assay...
February 23, 2024: Stem cell reviews and reports
https://read.qxmd.com/read/38388551/molecular-mechanism-underlying-mir-204-5p-regulation-of-adipose-derived-stem-cells-differentiation-into-cells-from-three-germ-layers
#40
JOURNAL ARTICLE
Zhimin Wang, Meiyu Bi, Xiaoshu Zhe, Xiao Wang, Bai Dai, Xiaoyu Han, Bingxu Ren, Hao Liang, Dongjun Liu
The limited differentiation ability of adipose-derived stem cells (ADSCs) limits their application in stem cell therapy and regenerative medicine. Here, we explore the molecular mechanism by which miR-204-5p regulates ADSCs differentiation into cells derived from the three germ layers (i.e., adipocytes, neurocytes, and hepatocytes). Although miR-204-5p overexpression inhibited ADSCs differentiation into adipocytes, neurocyte and hepatocyte differentiation were promoted. Mechanistically, miR-204-5p inhibited the expression of PPARG by regulating the AMPK signaling pathway, thereby inhibiting ADSCs differentiation into adipocytes...
February 22, 2024: Cell Death Discovery
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