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Rheumatoid arthrithis

Zhi-Chun Liu, Qiao-Ling Zhou, Xiao-Zhao Li, Jing-Hua Yang, Xiang Ao, Pouranan Veeraragoo, Xiao-Xia Zuo
Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a recently identified proinflammatory cytokine of the TNF superfamily. Studies have indicated that TWEAK plays an important role in renal, vascular injury and immune disease. The aim of this study was to explore the expression of the TWEAK in peripheral blood mononuclear cells (PBMCs) and analyze the correlation between TWEAK and disease activity and renal damage of SLE. The expression of TWEAK in PBMCs was determined by RT-PCR and western blot...
March 2011: Cytokine
Katarina Bauerova, Silvester Ponist, Jana Navarova, Martina Dubnickova, Ema Paulovicova, Martin Pajtinka, Grigorij Kogan, Danica Mihalova
OBJECTIVES: The aim of this study was to evaluate the effects of a biological response modifier, glucomannan (GM), isolated from Candida utilis, on the progress of adjuvant arthritis in Lewis rats. METHODS: Adjuvant arthrithis was induced in Lewis rats by a single intradermal injection of Mycobacterium butyricum. GM was administered in two different doses of 5 and 7.5 mg/kg b.w. The treatment involved daily oral or intraperitoneal administration of the substance from day 0, i...
October 2008: Neuro Endocrinology Letters
Alexei A Grom, Joyce Villanueva, Susan Lee, Ellen A Goldmuntz, Murray H Passo, Alexandra Filipovich
OBJECTIVES: To assess natural killer (NK) and cytotoxic functions in patients with systemic-onset juvenile rheumatoid arthrithis (soJRA) complicated by macrophage activation syndrome (MAS). METHODS: NK cells (CD56+/TCRalphabeta-), NK T cells (CD56+/TCRalphabeta+) and CD8+ cells were assessed for perforin expression by flow cytometry. NK cytotoxic activity was measured after coincubation of mononuclear cells with an NK-sensitive K562 cell line. RESULTS: Two major patterns of immunologic abnormalities were detected...
March 2003: Journal of Pediatrics
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