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https://www.readbyqxmd.com/read/29165615/human-herpesvirus-8-in-perinatally-hiv-infected-children-with-interstitial-lung-disease
#1
Marcelo Comerlato Scotta, Alexandre Todorovic Fabro, Paula Renata Lima Machado, Simone Gusmão Ramos, Maria Célia Cervi, Benedito Antônio Lopes da Fonseca, Fabrizio Motta, Bento Vidal de Moura Negrini
Introduction: Human herpesvirus 8 (HHV-8) is associated with the pathogenesis of Kaposi Sarcoma and interstitial pneumonitis in adults. This study aims to evaluate association between HHV-8 and interstitial lung disease in HIV-infected children. Methods: HIV-infected children with interstitial pneumonitis underwent lung biopsies in a tertiary hospital and were investigated for HHV-8, Epstein-Barr virus (EBV) and cytomegalovirus (CMV) using polymerase chain reaction (PCR) and immunohistochemistry in lung tissue...
November 20, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29162355/-hot-tub-lung-a-case-report
#2
M Vergez, S Honjoya, S Guérin, C Delacourt, G Benoist
Hot tub lung is a type of hypersensitivity pneumonitis caused by inhalational exposure to the Mycobacterium avium complex. We report the case of a 14-year-old boy presenting dyspnea with hypoxemia, whose medical history and clinical course helped make the diagnosis. Infectious causes were considered first, and antibiotics were initiated without success. Further questioning and explorations led to discussing a hypersensitivity pneumonitis diagnosis. Relapse after exposure to a hot tub enabled us to confirm hot tub lung...
November 18, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29162211/dynamics-of-the-pneumonic-plague-epidemic-in-madagascar-august-to-october-2017
#3
Shinya Tsuzuki, Hyojung Lee, Fuminari Miura, Yat Hin Chan, Sung-Mok Jung, Andrei R Akhmetzhanov, Hiroshi Nishiura
Transmission potential and severity of pneumonic plague in Madagascar were assessed. Accounting for reporting delay, the reproduction number was estimated at 1.73. The case fatality risk was estimated as 5.5%. Expected numbers of exported cases from Madagascar were estimated across the world and all estimates were below 1 person from August to October, 2017.
November 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29160385/usual-interstitial-pneumonia-typical-possible-and-inconsistent-patterns
#4
Pedro Paulo Teixeira E Silva Torres, Marcelo Fouad Rabahi, Maria Auxiliadora Carmo Moreira, Gustavo de Souza Portes Meirelles, Edson Marchiori
Idiopathic pulmonary fibrosis is a severe and progressive chronic fibrosing interstitial lung disease, a definitive diagnosis being established by specific combinations of clinical, radiological, and pathological findings. According to current international guidelines, HRCT plays a key role in establishing a diagnosis of usual interstitial pneumonia (UIP). Current guidelines describe three UIP patterns based on HRCT findings: a typical UIP pattern; a pattern designated "possible UIP"; and a pattern designated "inconsistent with UIP", each pattern having important diagnostic implications...
September 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29159034/hamman-rich-syndrome
#5
Arshiya Mastan, Nilaani Murugesu, Adil Hasnain, Terry O'Shaughnessy, Vladimir Macavei
INTRODUCTION: Acute interstitial pneumonia is a rare but important diagnosis, associated with a high mortality rate and important to identify early. CASE PRESENTATION: A 76 year-old individual presented to hospital with a two-week history of shortness of breath, fevers and a non-productive cough. Treatment initially was for lower respiratory tract infection but returned to hospital three days later as her shortness of breath and peripheral oedema was worsening despite diuretic treatment...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29159011/proton-therapy-for-malignant-pleural-mesothelioma-a-three-case-series-describing-the-clinical-and-dosimetric-advantages-of-proton-based-therapy
#6
Howard Lee, Jing Zeng, Stephen R Bowen, Ramesh Rengan
Malignant pleural mesothelioma (MPM) is a malignancy of the pleural cavity that typically presents at an advanced stage. Due to its large, circumferential clinical target volume (CTV) and proximity to major structures, including the heart and contralateral lung, delivering hemithoracic intensity-modulated radiotherapy (IMRT) with photon therapy to achieve loco-regional control following macroscopic complete resection is challenging. Intensity-modulated proton therapy (IMPT) has been shown to be a method for achieving higher therapeutic doses while limiting exposure to organs at risk (OARs), but patient outcomes after treatment have yet to be reported...
September 20, 2017: Curēus
https://www.readbyqxmd.com/read/29158363/phase-i-pharmacokinetic-study-of-nivolumab-in-korean-patients-with-advanced-solid-tumors
#7
Keun-Wook Lee, Dae Ho Lee, Jin Hyoung Kang, Joon Oh Park, Se Hyun Kim, Yong Sang Hong, Seung Tae Kim, Do-Youn Oh, Yung-Jue Bang
LESSONS LEARNED: This pharmacokinetic study of nivolumab showed that there is little ethnic difference in the handling of nivolumab.Nivolumab was well tolerated in Korean patients. BACKGROUND: This phase I study of nivolumab, an anti-programmed cell death-1 (anti-PD-1) monoclonal antibody, investigated the pharmacokinetics and safety of nivolumab in Korean patients with advanced solid tumors. Findings were compared with results from Japan and the U.S. MATERIALS AND METHODS: In this two-part study, patients received a single dose of nivolumab (1, 3, and 10 mg/kg; ONO-4538-13) and were followed up for 3 weeks...
November 20, 2017: Oncologist
https://www.readbyqxmd.com/read/29151967/new-clinical-features-and-dosimetric-predictor-identification-for-symptomatic-radiation-pneumonitis-after-tangential-irradiation-in-breast-cancer-patients
#8
Ge Wen, Yu-Ting Tan, Xiao-Wen Lan, Zhi-Chun He, Jiang-Hua Huang, Jun-Tian Shi, Xiao Lin, Xiao-Bo Huang
Background: Tangential irradiation is the most popular postoperative radiotherapy technique for breast cancer. However, irradiation has been related to symptomatic radiation pneumonitis (SRP), which decreases the quality of life of patients. This study investigated the clinical features and dosimetric parameters related to SRP of the ipsilateral lung to identify risk factors for SRP in breast cancer patients after three-dimensional conformal radiation therapy (3D-CRT) with tangential fields. Material and Methods: A total of 515 breast cancer patients were evaluated and divided into two groups: the local-regional irradiation group (259 patients) and the simple local irradiation group (256 patients)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29151274/effect-of-hmg-coa-reductase-inhibitors-on-the-development-of-chronic-lung-allograft-dysfunction
#9
Amanda Szczepanik, Amanda Hulbert, Hui-Jie Lee, Clark Benedetti, Laurie Snyder, Jennifer Byrns
Lung transplant recipients (LR) have a reduced median five-year survival of approximately 55% primarily due to chronic lung allograft dysfunction (CLAD). Statins have anti-inflammatory and immunomodulatory effects that may facilitate CLAD prevention. This study sought to evaluate statin effect on CLAD development. Adult bilateral LR from January 2004-October 2013 were included. Statin group included recipients with early statin use and continued for minimum 6 months. Propensity score matching was performed for age, gender and native lung disease to select matched non-statin group...
November 19, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29147933/aerobic-bacteriological-studies-on-the-respiratory-tracts-of-apparently-healthy-and-pneumonic-camels-camelus-dromedaries-in-selected-districts-of-afar-region-ethiopia
#10
Mu'uz Gebru, Genene Tefera, Fufa Dawo, Tesfaye Sisay Tessema
A cross-sectional study was conducted to isolate and identify bacterial species from the respiratory tract of apparently healthy and pneumonic camels in Asayita and Dubti woredas in the Afar Region, Ethiopia. From a total of 74 lung tissue and 74 tracheal swab samples Staphylococcus aureus, 16.3%, Streptococcus equi subsp. equi, 13.0%, and Pasteurella multocida, 10.9%, were dominant isolates from pneumonic lungs; Escherichia coli, 12.7%, Proteus species, 10.9%, and Klebsiella pneumoniae, 9.1%, were the majority in the normal lungs...
November 16, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29147577/nivolumab-for-nsclc-in-japanese-patients-similar-benefits-but-beware-of-pneumonitis
#11
EDITORIAL
Johan Vansteenkiste
No abstract text is available yet for this article.
2017: ESMO Open
https://www.readbyqxmd.com/read/29137669/blocked-expression-of-key-genes-of-the-angiogenic-pathway-in-jsrv-induced-pulmonary-adenocarcinomas
#12
Maryline Gomes, Fabienne Archer, Nicolas Girard, Barbara Gineys, Christine Dolmazon, Alexandra Bobet Erny, Jean-François Mornex, Caroline Leroux
JSRV (Jaagsiekte Sheep Retrovirus) is a retrovirus inducing a transmissible lung adenocarcinoma in sheep and goats with predominantly lepidic and papillary lesions. This naturally occurring lung cancer in large animals shares many features with human pneumonic-type lung adenocarcinomas with predominant lepidic growth. The metastatic spread is rare in both human and animal cancers. This unique feature prompted us to decipher the angiogenesis pathway in these cancers. We focused on the levels of mRNA and proteins of genes implicated in the extension of JSRV-induced lung adenocarcinomas by studying their expression in lung cancers (n = 10) and normal lungs (n = 10) and in primary epithelial alveolar type II cells derived from cancers (n = 10) or normal lungs (n = 6)...
November 14, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29137320/a-phase-ii-study-of-s-1-with-concurrent-radiotherapy-in-elderly-patients-with-esophageal-cancer
#13
Yongling Ji, Xianghui Du, Ye Tian, Liming Sheng, Lei Cheng, Ying Chen, Guoqing Qiu, Xia Zhou, Wuan Bao, Danhong Zhang, Ming Chen
Background: Concurrent chemoradiotherapy (CCRT) using conventional platinum-based doublets are often associated with significant incidence of toxic effects in elderly patients with esophageal cancer. We previously reported a phase I trial of CCRT using S-1, an oral 5-fluorouracil derivative, which yielded well safe and active outcomes. Methods: Patients with histologically confirmed esophageal cancer, who were age of 70 years or older with performance status (PS) score of 0-2 or age of 66 to 69 with PS score of 2, were eligible for this Phase II trial...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136621/evaluation-of-nickel-release-from-endobronchial-valves-as-a-possible-cause-of-hypersensitivity-pneumonitis-in-a-patient-treated-with-bronchoscopic-lung-volume-reduction
#14
Daniel P Franzen, Claudia Lang, Nikos Agorastos, Lutz Freitag, Malcolm Kohler, Peter Schmid-Grendelmeier
BACKGROUND: Endobronchial valve (EBV) placement is an established lung volume reduction procedure aiming to improve lung function and exercise capacity in patients with severe emphysema. As EBVs consist of silicone and nitinol (a metal alloy of nickel and titanium), there are concerns that nickel ions might be released and could have a clinical impact in patients with a contact allergy to nickel. Based on a case with hypersensitivity pneumonitis (HP) after treatment with EBVs, we aimed to evaluate the in vitro nickel release from EBVs using inductively coupled plasma mass spectrometry (ICP-MS) and scanning electron microscopy (SEM)...
November 15, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29136201/safety-and-tolerability-of-selumetinib-as-a-monotherapy-or-in-combination-with-docetaxel-as-second-line-therapy-in-japanese-patients-with-advanced-solid-malignancies-or-non-small-cell-lung-cancer
#15
Takashi Seto, Fumihiko Hirai, Hideo Saka, Yoshihito Kogure, Kiyotaka Yoh, Seiji Niho, Kenjiro Fukase, Hitoshi Shimada, Michitaka Sasai, Koichi Fukino
Objective: This Phase I study (NCT01605916) investigated the safety, tolerability and pharmacokinetic profile of selumetinib plus docetaxel as second-line therapy in Japanese patients with locally advanced or metastatic non-small cell lung cancer (NSCLC), or selumetinib monotherapy in Japanese patients with advanced solid malignancies. Methods: All enrolled patients received single-dose selumetinib 25, 50 or 75 mg, followed by a 3-day washout. Combination therapy cohorts then started a 21-day cycle of docetaxel 60 mg/m2 plus selumetinib 25 or 75 mg twice-daily (BID) on Day 1...
November 10, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29136066/unsuspected-lymphomatoid-granulomatosis-in-a-patient-with-antisynthetase-syndrome
#16
Stephanie L Skala, Alexandra C Hristov, Johann E Gudjonsson, May P Chan
Clinical diagnosis of lymphomatoid granulomatosis (LYG) often is difficult, especially in patients with multiple comorbidities. We present a 60-year-old woman with worsening fatigue, night sweats, unintentional weight loss, and dyspnea of 2 weeks' duration. Her medical history was remarkable for recent radiation therapy for recurrent breast cancer and antisynthetase syndrome complicated by interstitial lung disease and controlled with azathioprine. Computed tomography showed ground-glass opacities and nodular infiltrates in all lung lobes, raising concern for radiation pneumonitis and drug toxicity...
October 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29133768/severe-pneumonitis-after-nivolumab-treatment-accompanied-by-acute-pulmonary-embolism-in-a-patient-with-lung-adenocarcinoma
#17
Ji-Ping Liao, Li-Gong Nie, Cheng-Li Que, Xiang-Dong Mu
No abstract text is available yet for this article.
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29132803/high-dose-irradiation-after-pleurectomy-decortication-or-biopsy-for-pleural-mesothelioma-treatment
#18
E Parisi, A Romeo, A Sarnelli, G Ghigi, S R Bellia, E Neri, S Micheletti, B Dipalma, D Arpa, G Furini, M A Burgio, G Genestreti, C Gurioli, S Sanna, P Bovolato, F Rea, G Storme, E Scarpi, C Arienti, A Tesei, R Polico
PURPOSE: The role played by radiation therapy after pleurectomy/decortication or surgical biopsy in malignant pleural mesothelioma is uncertain. We treated patients with accelerated hypofractionated radiotherapy using helical tomotherapy and intensity-modulated arc therapy in an attempt to keep lung toxicity to a minimum. The present study reports the feasibility and toxicity of this approach. MATERIAL AND METHODS: Between 2008 and 2012, 36 patients with malignant pleural mesothelioma underwent accelerated hypofractionated radiotherapy to the hemithorax after pleurectomy/decortication (19 patients) or biopsy (17 patients)...
November 10, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29129538/pneumonia-in-the-tropics-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#19
REVIEW
Mohd Basri Mat Nor, Guy A Richards, Steve McGloughlin, Pravin R Amin
The aetiology of community acquired pneumonia varies according to the region in which it is acquired. This review discusses those causes of CAP that occur in the tropics and might not be readily recognizable when transplanted to other sites. Various forms of pneumonia including the viral causes such as influenza (seasonal and avian varieties), the coronaviruses and the Hantavirus as well as bacterial causes, specifically the pneumonic form of Yersinia pestis and melioidosis are discussed.
November 3, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29128934/radiobiological-analysis-of-stereotactic-body-radiation-therapy-for-an-evidence-based-planning-target-volume-of-the-lung-using-multiphase-ct-images-obtained-with-a-pneumatic-abdominal-compression-apparatus-a-case-study
#20
Arun Chairmadurai, Harish Chandra Goel, Sandeep Kumar Jain, Pawan Kumar
This study evaluated the efficiency of stereotactic body radiation therapy of lung (SBRT-Lung) in generating a treatment volume using conventional multiple-phase three-dimensional computed tomography (3D-CT) of a patient immobilized with pneumatic abdominal compression. The institutional protocol for SBRT-Lung using the RapidArc technique relied on a planning target volume (PTV) delineated using 3D-CT and accounted for linear and angular displacement of the tumor during respiratory movements. The efficiency of the institutional protocol was compared with that of a conventional method for PTV delineation based on radiobiological estimates, such as tumor control probability (TCP) and normal tissue complication probability (NTCP), evaluated using dose-volume parameters...
November 11, 2017: Radiological Physics and Technology
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