keyword
MENU ▼
Read by QxMD icon Read
search

pyroptosis

keyword
https://www.readbyqxmd.com/read/27932073/pyroptosis-gasdermin-mediated-programmed-necrotic-cell-death
#1
REVIEW
Jianjin Shi, Wenqing Gao, Feng Shao
Pyroptosis was long regarded as caspase-1-mediated monocyte death in response to certain bacterial insults. Caspase-1 is activated upon various infectious and immunological challenges through different inflammasomes. The discovery of caspase-11/4/5 function in sensing intracellular lipopolysaccharide expands the spectrum of pyroptosis mediators and also reveals that pyroptosis is not cell type specific. Recent studies identified the pyroptosis executioner, gasdermin D (GSDMD), a substrate of both caspase-1 and caspase-11/4/5...
December 5, 2016: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/27917412/zbp1-dai-is-an-innate-sensor-of-influenza-virus-triggering-the-nlrp3-inflammasome-and-programmed-cell-death-pathways
#2
Teneema Kuriakose, Si Ming Man, R K Subbarao Malireddi, Rajendra Karki, Sannula Kesavardhana, David E Place, Geoffrey Neale, Peter Vogel, Thirumala-Devi Kanneganti
The interferon-inducible protein Z-DNA binding protein 1 (ZBP1, also known as DNA-dependent activator of IFN-regulatory factors (DAI) and DLM-1) was identified as a dsDNA sensor, which instigates innate immune responses. However, this classification has been disputed and whether ZBP1 functions as a pathogen sensor during an infection has remained unknown. Herein, we demonstrated ZBP1-mediated sensing of the influenza A virus (IAV) proteins NP and PB1, triggering cell death and inflammatory responses via the RIPK1-RIPK3-Caspase-8 axis...
August 5, 2016: Science Immunology
https://www.readbyqxmd.com/read/27914458/inactivation-of-inflammasomes-by-pathogens-regulates-inflammation
#3
REVIEW
F Yu Garib, A P Rizopulu, A A Kuchmiy, V F Garib
Inflammatory response is initiated and sustained by the action of quintessential pro-inflammatory cytokines of immune system namely IL-1β and IL-18. The maturation process of those cytokines is ensured by caspase-1 enzymatic activity, that is in turn is tightly controlled by multiprotein complexes called inflammasomes. Inflammasomes are activated in cells of innate immune system in response to recognition of conservative parts of microbes (pathogen-associated molecular patterns) or by sensing molecular signs of tissue damage (damage-associated molecular patterns)...
November 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/27900566/autophagy-regulates-death-of-retinal-pigment-epithelium-cells-in-age-related-macular-degeneration
#4
REVIEW
Kai Kaarniranta, Paulina Tokarz, Ali Koskela, Jussi Paterno, Janusz Blasiak
Age-related macular degeneration (AMD) is an eye disease underlined by the degradation of retinal pigment epithelium (RPE) cells, photoreceptors, and choriocapillares, but the exact mechanism of cell death in AMD is not completely clear. This mechanism is important for prevention of and therapeutic intervention in AMD, which is a hardly curable disease. Present reports suggest that both apoptosis and pyroptosis (cell death dependent on caspase-1) as well as necroptosis (regulated necrosis dependent on the proteins RIPK3 and MLKL, caspase-independent) can be involved in the AMD-related death of RPE cells...
November 29, 2016: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/27872238/phagosomal-neutralization-by-the-fungal-pathogen-candida-albicans-induces-macrophage-pyroptosis
#5
Slavena Vylkova, Michael C Lorenz
The interaction of Candida albicans with the innate immune system is the key determinant of the pathogen/commensal balance and has selected for adaptations that facilitate the utilization of nutrients commonly found within the host, including proteins and amino acids; many of the catabolic pathways needed to assimilate these compounds are required for persistence in the host. We have shown that C. albicans co-opts amino acid catabolism to generate and excrete ammonia, which raises extracellular pH, both in vitro and in vivo and induces hyphal morphogenesis...
November 21, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27860556/immunopathogenesis-of-dengue-virus-induced-redundant-cell-death-apoptosis-and-pyroptosis
#6
San Suwanmanee, Natthanej Luplertlop
Dengue virus infection is a self-limited condition, which is of particular importance in tropical and subtropical regions and for which no specific treatment or effective vaccine is available. There are several hypotheses explaining dengue pathogenesis. These usually refer to host immune responses, including antibody-dependent enhancement, cytokine expression, and dengue virus particles including NS1 protein, which lead to cell death by both apoptosis and pyroptosis. A clear understanding of the pathogenesis should facilitate the development of vaccines and therapies...
November 18, 2016: Viral Immunology
https://www.readbyqxmd.com/read/27853287/pyroptosis-of-salmonella-typhimurium-infected-macrophages-was-suppressed-and-elimination-of-intracellular-bacteria-from-macrophages-was-promoted-by-blocking-qsec
#7
Zhi Li, Qing Zheng, Xiaoyan Xue, Xin Shi, Ying Zhou, Fei Da, Di Qu, Zheng Hou, Xiaoxing Luo
QseC is a membrane-bound histidine sensor kinase found in Gram-negative pathogens and is involved in the regulation of bacterial virulence. LED209, a QseC-specific inhibitor, significantly inhibits the virulence of several pathogens and partially protects infected mice from death by blocking QseC. However, the mechanism of its antibacterial effects remains unclear. In this experiment, a Salmonella Typhimurium (S. Typhimurium) and macrophage co-culture system was utilized to investigate possible mechanisms underlying the antimicrobial effects of the QseC inhibitor...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27832707/caspase-1-activity-in-cd4-t-cells-is-downregulated-following-antiretroviral-therapy-for-hiv-1-infection
#8
Rentian Cai, Li Liu, Bin Luo, Jiangrong Wang, Jiayin Shen, Yinzhong Shen, Renfang Zhang, Jun Chen, Hongzhou Lu
Both Caspase 1- and Caspase 3-induced cell death were reported to be the causes of CD4+ T cell depletion in HIV-infection. We measured by flow cytometry the expression of key proteins associated with pyroptosis (Caspase 1), apoptosis (Caspase 3, Caspase 8, Caspase 9), and immune activation in peripheral T cells. The percentages of CD4+ T cells that expressed Caspase 1 and Caspase 3 were significantly higher in untreated HIV-1 patients as compared with healthy control [Caspase 1: 19.40% vs. 4.65%, p = 0.006; Caspase 3: 12...
November 10, 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27826146/a-motive-for-killing-effector-functions-of-regulated-lytic-cell-death
#9
REVIEW
Meghan Bliss-Moreau, Alyce A Chen, Akshay D'Cruz, Ben A Croker
Immunological responses activated by pathogen recognition come in many guises. The proliferation, differentiation, and recruitment of immune cells, and the production of inflammatory cytokines and chemokines are central to lifelong immunity. Cell death serves as a key function in the resolution of innate and adaptive immune responses. It also coordinates cell-intrinsic effector functions to restrict infection. Necrosis was formally considered a passive form of cell death or a consequence of pathogen virulence factor expression, and necrotic tissue was associated with infection...
November 9, 2016: Immunology and Cell Biology
https://www.readbyqxmd.com/read/27821585/listeria-monocytogenes-induced-cell-death-inhibits-the-generation-of-cell-mediated-immunity
#10
Erin Theisen, John-Demian Sauer
The influence of cell death on adaptive immunity has been studied for decades. Despite these efforts, the intricacies of how various cell death pathways shape immune responses in the context of infection remain unclear, particularly with regards to more recently discovered pathways such as pyroptosis. The emergence of Listeria monocytogenes as a promising immunotherapeutic platform demand a thorough understanding of how cell death induced in the context of infection influences the generation of CD8+ T-cell mediated immune responses...
November 7, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27820798/dpp8-and-dpp9-inhibition-induces-pro-caspase-1-dependent-monocyte-and-macrophage-pyroptosis
#11
Marian C Okondo, Darren C Johnson, Ramya Sridharan, Eun Bin Go, Ashley J Chui, Mitchell S Wang, Sarah E Poplawski, Wengen Wu, Yuxin Liu, Jack H Lai, David G Sanford, Michael O Arciprete, Todd R Golub, William W Bachovchin, Daniel A Bachovchin
Val-boroPro (Talabostat, PT-100), a nonselective inhibitor of post-proline cleaving serine proteases, stimulates mammalian immune systems through an unknown mechanism of action. Despite this lack of mechanistic understanding, Val-boroPro has attracted substantial interest as a potential anticancer agent, reaching phase 3 trials in humans. Here we show that Val-boroPro stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis. We demonstrate that the inhibition of two serine proteases, DPP8 and DPP9, activates the pro-protein form of caspase-1 independent of the inflammasome adaptor ASC...
November 7, 2016: Nature Chemical Biology
https://www.readbyqxmd.com/read/27813025/involvement-of-programmed-cell-death-in-neurotoxicity-of-metallic-nanoparticles-recent-advances-and-future-perspectives
#12
REVIEW
Bin Song, Ting Zhou, Jia Liu, LongQuan Shao
The widespread application of metallic nanoparticles (NPs) or NP-based products has increased the risk of exposure to NPs in humans. The brain is an important organ that is more susceptible to exogenous stimuli. Moreover, any impairment to the brain is irreversible. Recently, several in vivo studies have found that metallic NPs can be absorbed into the animal body and then translocated into the brain, mainly through the blood-brain barrier and olfactory pathway after systemic administration. Furthermore, metallic NPs can cross the placental barrier to accumulate in the fetal brain, causing developmental neurotoxicity on exposure during pregnancy...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27812336/piperine-suppresses-pyroptosis-and-interleukin-1%C3%AE-release-upon-atp-triggering-and-bacterial-infection
#13
Yi-Dan Liang, Wen-Jing Bai, Chen-Guang Li, Li-Hui Xu, Hong-Xia Wei, Hao Pan, Xian-Hui He, Dong-Yun Ouyang
Piperine is a phytochemical present in black pepper (Piper nigrum Linn) and other related herbs, possessing a wide array of pharmacological activities including anti-inflammatory effects. Previously, we demonstrated that piperine has therapeutic effects on bacterial sepsis in mice, but the underlying mechanism has not been fully elucidated. In this study, we aimed to investigate the influences of piperine on pyroptosis in murine macrophages. The results showed that piperine dose-dependently inhibited ATP-induced pyroptosis, thereby suppressing interleukin-1β (IL-1β) or high mobility group box-1 protein (HMGB1) release in LPS-primed bone marrow-derived macrophages and J774A...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27811014/regulated-necrosis-related-molecule-mrna-expression-in-humans-mice-and-murine-acute-tissue-injury-systemic-autoimmunity-leading-to-progressive-organ-damage-and-progressive-fibrosis
#14
Mohsen Honarpisheh, Jyaysi Desai, Julian A Marschner, Marc Weidenbusch, Maciej Lech, Volker Vielhauer, Hans-Joachim Anders, Shrikant R Mulay
The species-specific, as well as organ-specific expression of regulated necrosis (RN)-related molecules, is not known. We determined the expression levels of TNFR1, RIPK1, RIPK3, MLKL, CASP8, FADD, CIAP1, CIAP2, GPX4, CYPD, CASP1, NLRP3, and PARP1 in human and mouse solid organs. We observed significant differences in expression of these molecules between human and mice. In addition, we characterized their expression profiles in acute as well as persistent tissue injury and chronic tissue remodeling using acute and chronic kidney injury models...
November 3, 2016: Bioscience Reports
https://www.readbyqxmd.com/read/27808091/growth-inhibition-of-cytosolic-salmonella-by-caspase-1-and-caspase-11-precedes-host-cell-death
#15
Teresa L M Thurston, Sophie A Matthews, Elliott Jennings, Eric Alix, Feng Shao, Avinash R Shenoy, Mark A Birrell, David W Holden
Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory cytokines interleukin (IL)-18 and IL-1β. In addition, mouse caspase-11 (represented in humans by its orthologs, caspase-4 and caspase-5) detects cytosolic bacterial LPS directly. Activation of caspase-1 and caspase-11 initiates pyroptotic host cell death that releases potentially harmful bacteria from the nutrient-rich host cell cytosol into the extracellular environment...
November 3, 2016: Nature Communications
https://www.readbyqxmd.com/read/27803513/atp-induces-il-1%C3%AE-secretion-in-neisseria-gonorrhoeae-infected-human-macrophages-by-a-mechanism-not-related-to-the-nlrp3-asc-caspase-1-axis
#16
Killen García, Gisselle Escobar, Pablo Mendoza, Caroll Beltran, Claudio Perez, Sergio Arancibia, Rolando Vernal, Paula I Rodas, Claudio Acuña-Castillo, Alejandro Escobar
Neisseria gonorrhoeae (Ngo) has developed multiple immune evasion mechanisms involving the innate and adaptive immune responses. Recent findings have reported that Ngo reduces the IL-1β secretion of infected human monocyte-derived macrophages (MDM). Here, we investigate the role of adenosine triphosphate (ATP) in production and release of IL-1β in Ngo-infected MDM. We found that the exposure of Ngo-infected MDM to ATP increases IL-1β levels about ten times compared with unexposed Ngo-infected MDM (P < 0...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27803173/inhibition-of-phagocytosis-and-pyroptosis-of-macrophages-promotes-bartonella-invasion-into-the-bloodstream-through-lymphatic-circulation
#17
Jiehua Hong, Yan Li, Xiuguo Hua, Yajie Bai, Chunyan Wang, Caixia Zhu, Yuming Du, Zhibiao Yang, Congli Yuan
The hallmark of Bartonella infection is long-lasting intra-erythrocytic parasitism. However, the process of Bartonella bacteremia is still enigmatic. Here, we used Bartonella tribocorum (Bt) to understand how Bartonella invasion into the bloodstream from dermal inoculation might occur. Bartonella was poorly phagocytized by peritoneal macrophages in vitro. Intracellular Bartonella survived and replicated in macrophages at early stage of infection. Intracellular Bartonella inhibited spontaneous cell death of macrophage...
October 31, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27798227/cell-death-mechanisms-in-human-chronic-liver-diseases-a-far-cry-from-clinical-applicability
#18
REVIEW
Guillermo Mazzolini, Jan-Peter Sowa, Ali Canbay
The liver is constantly exposed to a host of injurious stimuli. This results in hepatocellular death mainly by apoptosis and necrosis, but also due to autophagy, necroptosis, pyroptosis and in some cases by an intricately balanced combination thereof. Overwhelming and continuous cell death in the liver leads to inflammation, fibrosis, cirrhosis, and eventually hepatocellular carcinoma. Although data from various disease models may suggest a specific (predominant) cell death mode for different aetiologies, the clinical reality is not as clear cut...
December 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27777967/nod-like-receptor-protein-3-inflammasome-priming-and-activation-in-barrett-s-epithelial-cells
#19
Yuji Nadatani, Xiaofang Huo, Xi Zhang, Chunhua Yu, Edaire Cheng, Qiuyang Zhang, Kerry B Dunbar, Arianne Theiss, Thai H Pham, David H Wang, Toshio Watanabe, Yasuhiro Fujiwara, Tetsuo Arakawa, Stuart J Spechler, Rhonda F Souza
BACKGROUND & AIMS: Microbial molecular products incite intestinal inflammation by activating Toll-like receptors (TLRs) and inflammasomes of the innate immune system. This system's contribution to esophageal inflammation is not known. Gram-negative bacteria, which dominate the esophageal microbiome in reflux esophagitis, produce lipopolysaccharide (LPS), a TLR4 ligand. TLR4 signaling produces pro-interleukin (IL)1β, pro-IL18, and NOD-like receptor protein 3 (NLRP3), which prime the NLRP3 inflammasome...
July 2016: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27774931/-c1q-and-tumor-necrosis-factor-related-protein-4-ctrp4-suppresses-caspase-1-il-1%C3%AE-inflammatory-pathway-in-trophoblasts-of-rat-models-with-preeclampsia
#20
Lili Duan, Zidong Liu, Lin Wang, Binfang Ma, Yibing Fan, Ying Xu, Fenfen Guo
Objective To explore the effect of C1q/tumor necrosis factor related protein 4 (CTRP4) on the placental trophoblasts of preeclampsia model rats. Methods Placental trophoblastic tissues were respectively collected from normal pregnant rats and model rats with preeclampsia, and then mRNA and protein expression levels of CTRP4, interleukin 1β (IL-1β), and caspase-1 were detected with quantitative real-time PCR (qRT-PCR) and Western blotting. Primary placental trophoblasts were isolated from normal pregnant rats and model rats; at different time points, flow cytometry was used to detect the number of PI(+)caspase-1(+) pyroptotic cells; and qRT-PCR and Western blotting were used to detect expression levels of IL-1β and caspase-1...
November 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
keyword
keyword
99097
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"