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Multiple sclerosis and iron

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https://www.readbyqxmd.com/read/29868452/changes-of-deep-gray-matter-magnetic-susceptibility-over-2-years-in-multiple-sclerosis-and-healthy-control-brain
#1
Jesper Hagemeier, Robert Zivadinov, Michael G Dwyer, Paul Polak, Niels Bergsland, Bianca Weinstock-Guttman, Joshua Zalis, Andreas Deistung, Jürgen R Reichenbach, Ferdinand Schweser
In multiple sclerosis, pathological changes of both tissue iron and myelin occur, yet these factors have not been characterized in a longitudinal fashion using the novel iron- and myelin-sensitive quantitative susceptibility mapping (QSM) MRI technique. We investigated disease-relevant tissue changes associated with myelin loss and iron accumulation in multiple sclerosis deep gray matter (DGM) over two years. One-hundred twenty (120) multiple sclerosis patients and 40 age- and sex-matched healthy controls were included in this prospective study...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29748743/erythropoietin-and-nrf2-key-factors-in-the-neuroprotection-provided-by-apo-lactoferrin
#2
E T Zakharova, A V Sokolov, N N Pavlichenko, V A Kostevich, I N Abdurasulova, A V Chechushkov, I V Voynova, A Yu Elizarova, N N Kolmakov, M G Bass, I V Semak, A I Budevich, P M Kozhin, N K Zenkov, V M Klimenko, O V Kirik, D E Korzhevskii, E B Menshchikova, V B Vasilyev
Among the properties of lactoferrin (LF) are bactericidal, antianemic, immunomodulatory, antitumour, antiphlogistic effects. Previously we demonstrated its capacity to stabilize in vivo HIF-1-alpha and HIF-2-alpha, which are redox-sensitive multiaimed transcription factors. Various tissues of animals receiving recombinant human LF (rhLF) responded by expressing the HIF-1-alpha target genes, hence such proteins as erythropoietin (EPO), ceruloplasmin, etc. were synthesized in noticeable amounts. Among organs in which EPO synthesis occurred were brain, heart, spleen, liver, kidneys and lungs...
May 10, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29713769/optic-radiations-are-thinner-and-show-signs-of-iron-deposition-in-patients-with-long-standing-remitting-relapsing-multiple-sclerosis-an-enhanced-t-2-weighted-angiography-imaging-study
#3
Chun Zeng, Silin Du, Yongliang Han, Jialiang Fu, Qi Luo, Yayun Xiang, Xiaoya Chen, Tianyou Luo, Yongmei Li, Yineng Zheng
OBJECTIVE: This study aimed to investigate iron deposition and thickness and signal changes in optic radiation (OR) by enhanced T2 * -weighted angiography imaging (ESWAN) in patients with relapsing-remitting multiple sclerosis (RRMS) with unilateral and bilateral lesions or no lesions. METHODS: Fifty-one RRMS patients (42 patients with a disease duration [DD] ≥ 2 years [group Mor], nine patients with a DD < 2 years [group Les]) and 51 healthy controls (group Con) underwent conventional magnetic resonance imaging (MRI) and ESWAN at 3...
April 30, 2018: European Radiology
https://www.readbyqxmd.com/read/29702183/quantifying-iron-content-in-magnetic-resonance-imaging
#4
Kiarash Ghassaban, Saifeng Liu, Caihong Jiang, E Mark Haacke
Measuring iron content has practical clinical indications in the study of diseases such as Parkinson's disease, Huntington's disease, ferritinopathies and multiple sclerosis as well as in the quantification of iron content in microbleeds and oxygen saturation in veins. In this work, we review the basic concepts behind imaging iron using T2, T2*, T2', phase and quantitative susceptibility mapping in the human brain, liver and heart, followed by the applications of in vivo iron quantification in neurodegenerative diseases, iron tagged cells and ultra-small superparamagnetic iron oxide (USPIO) nanoparticles...
April 25, 2018: NeuroImage
https://www.readbyqxmd.com/read/29687337/monodisperse-magnetic-poly-glycidyl-methacrylate-microspheres-for-isolation-of-autoantibodies-with-affinity-for-the-46-kda-form-of-unconventional-myo1c-present-in-autoimmune-patients
#5
Beata A Zasońska, Helena Hlídková, Eduard Petrovský, Severyn Myronovskij, Tetyana Nehrych, Nazar Negrych, Mariya Shorobura, Volodymyr Antonyuk, Rostyslav Stoika, Yuriy Kit, Daniel Horák
Monodisperse nonmagnetic macroporous poly(glycidyl methacrylate) (PGMA) microspheres were synthesized by multistep swelling polymerization of glycidyl methacrylate, ethylene dimethacrylate and 2-[(methoxycarbonyl)methoxy]ethyl methacrylate (MCMEMA). This was followed (a) by ammonolysis to modify the microspheres with amino groups, and (b) by incorporation of iron oxide (γ-Fe2 O3 ) into the pores to render the particles magnetic. The resulting porous and magnetic microspheres were characterized by scanning and transmission electron microscopy (SEM and TEM), atomic absorption and Fourier transform infrared spectroscopy (AAS and FTIR), elemental analysis, vibrating magnetometry, mercury porosimetry and Brunauer-Emmett-Teller adsorption/desorption isotherms...
April 23, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29629528/prevalence-of-multiple-sclerosis-in-a-turkish-city-bordering-an-iron-and-steel-factory
#6
Ülkü Türk Börü, Adnan Burak Bilgiç, Cansu Köseoğlu Toksoy, Abdullah Yasir Yılmaz, Mustafa Tasdemir, Nilay Padir Sensöz, Özgür Öztop Çakmak, Arda Duman, Cem Bölük
BACKGROUND AND PURPOSE: Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory demyelination. Recent studies have shown that long-term exposure to air pollutants (including PM10 particulates) is potentially an environmental risk factor for MS. We aimed to determine the prevalence rates of MS in two cities with different levels of air pollution. METHODS: This door-to-door population-based study was conducted between April 2014 and June 2015...
April 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29575574/no-effects-without-causes-the-iron-dysregulation-and-dormant-microbes-hypothesis-for-chronic-inflammatory-diseases
#7
Douglas B Kell, Etheresia Pretorius
Since the successful conquest of many acute, communicable (infectious) diseases through the use of vaccines and antibiotics, the currently most prevalent diseases are chronic and progressive in nature, and are all accompanied by inflammation. These diseases include neurodegenerative (e.g. Alzheimer's, Parkinson's), vascular (e.g. atherosclerosis, pre-eclampsia, type 2 diabetes) and autoimmune (e.g. rheumatoid arthritis and multiple sclerosis) diseases that may appear to have little in common. In fact they all share significant features, in particular chronic inflammation and its attendant inflammatory cytokines...
March 25, 2018: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/29561895/untangling-the-r2-contrast-in-multiple-sclerosis-a-combined-mri-histology-study-at-7-0-tesla
#8
Francesca Bagnato, Simon Hametner, Emma Boyd, Verena Endmayr, Yaping Shi, Vasiliki Ikonomidou, Guanhua Chen, Siddharama Pawate, Hans Lassmann, Seth Smith, E Brian Welch
T2*-weighted multi-echo gradient-echo magnetic resonance imaging and its reciprocal R2* are used in brain imaging due to their sensitivity to iron content. In patients with multiple sclerosis who display pathological alterations in iron and myelin contents, the use of R2* may offer a unique way to untangle mechanisms of disease. Coronal slices from 8 brains of deceased multiple sclerosis patients were imaged using a whole-body 7.0 Tesla MRI scanner. The scanning protocol included three-dimensional (3D) T2*-w multi-echo gradient-echo and 2D T2-w turbo spin echo (TSE) sequences...
2018: PloS One
https://www.readbyqxmd.com/read/29537720/discriminative-analysis-of-regional-evolution-of-iron-and-myelin-calcium-in-deep-gray-matter-of-multiple-sclerosis-and-healthy-subjects
#9
Ahmed M Elkady, Dana Cobzas, Hongfu Sun, Gregg Blevins, Alan H Wilman
BACKGROUND: Combined R2* and quantitative susceptibility (QS) has been previously used in cross-sectional multiple sclerosis (MS) studies to distinguish deep gray matter (DGM) iron accumulation and demyelination. PURPOSE: We propose and apply discriminative analysis of regional evolution (DARE) to define specific changes in MS and healthy DGM. STUDY TYPE: Longitudinal (baseline and 2-year follow-up) retrospective study. SUBJECTS: Twenty-seven relapsing-remitting MS (RRMS), 17 progressive MS (PMS), and corresponding age-matched healthy subjects...
March 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29515576/significance-and-in-vivo-detection-of-iron-laden-microglia-in-white-matter-multiple-sclerosis-lesions
#10
Kelly M Gillen, Mayyan Mubarak, Thanh D Nguyen, David Pitt
Microglia are resident immune cells that fulfill protective and homeostatic functions in the central nervous system (CNS) but may also promote neurotoxicity in the aged brain and in chronic disease. In multiple sclerosis (MS), an autoimmune demyelinating disease of the CNS, microglia and macrophages contribute to the development of white matter lesions through myelin phagocytosis, and possibly to disease progression through diffuse activation throughout myelinated white matter. In this review, we discuss an additional compartment of myeloid cell activation in MS, i...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29507614/molecular-magnetic-resonance-imaging-of-endothelial-activation-in-the-central-nervous-system
#11
REVIEW
Maxime Gauberti, Antoine P Fournier, Fabian Docagne, Denis Vivien, Sara Martinez de Lizarrondo
Endothelial cells of the central nervous system over-express surface proteins during neurological disorders, either as a cause, or a consequence, of the disease. Since the cerebral vasculature is easily accessible by large contrast-carrying particles, it constitutes a target of choice for molecular magnetic resonance imaging (MRI). In this review, we highlight the most recent advances in molecular MRI of brain endothelial activation and focus on the development of micro-sized particles of iron oxide (MPIO) targeting adhesion molecules including intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), P-Selectin and E-Selectin...
2018: Theranostics
https://www.readbyqxmd.com/read/29497049/redox-metals-homeostasis-in-multiple-sclerosis-and-amyotrophic-lateral-sclerosis-a-review
#12
REVIEW
Sahar Sheykhansari, Kristen Kozielski, Joachim Bill, Metin Sitti, Donato Gemmati, Paolo Zamboni, Ajay Vikram Singh
The effect of redox metals such as iron and copper on multiple sclerosis and amyotrophic lateral sclerosis has been intensively studied. However, the origin of these disorders remains uncertain. This review article critically describes the physiology of redox metals that produce oxidative stress, which in turn leads to cascades of immunomodulatory alteration of neurons in multiple sclerosis and amyotrophic lateral sclerosis. Iron and copper overload has been well established in motor neurons of these diseases' lesions...
March 1, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29477226/riboflavin-in-human-health-a-review-of-current-evidences
#13
REVIEW
Ahmad Saedisomeolia, Marziyeh Ashoori
Riboflavin is a water-soluble vitamin, which was initially isolated from milk. There are two coenzyme forms of riboflavin, flavin mononucleotide and flavin adenine dinucleotide, in which riboflavin plays important roles in the enzymatic reactions. Riboflavin is found in a wide variety of animal and plant foods. Meat and dairy products are the major contributors of riboflavin dietary intake. In this chapter, the latest evidence on the relationship between riboflavin status and specific health risks will be reviewed...
2018: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/29464444/cuprizone-administration-alters-the-iron-metabolism-in-the-mouse-model-of-multiple-sclerosis
#14
E Varga, E Pandur, H Abrahám, A Horváth, P Ács, S Komoly, A Miseta, K Sipos
Cuprizone (CZ) is a widely used copper chelating agent to develop non-autoimmune animal model of multiple sclerosis, characterized by demyelination of the corpus callosum (CC) and other brain regions. The exact mechanisms of CZ action are still arguable, but it seems that the only affected cells are the mature oligodendrocytes, possibly via metabolic disturbances caused by copper deficiency. During the pathogenesis of multiple sclerosis, high amount of deposited iron can be found throughout the demyelinated areas of the brain in the form of extracellular iron deposits and intracellularly accumulated iron in microglia...
February 20, 2018: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29457657/semaphorin4a-and-h-ferritin-utilize-tim-1-on-human-oligodendrocytes-a-novel-neuro-immune-axis
#15
Brian Chiou, Elisabeth Lucassen, Michael Sather, Asha Kallianpur, James Connor
Deficiency of trophic factors relating to the survival of oligodendrocytes, combined with direct interactions with the immune system, are favored paradigms that are increasingly implicated in demyelinating diseases of the central nervous system. We and others have previously shown that Sema4A and H-ferritin interact through the T-cell immunoglobulin and mucin domain (Tim-2) receptor in mice. H-ferritin has been identified as the iron delivery protein for oligodendrocytes, whereas Sema4A causes a direct cytotoxic effect...
February 19, 2018: Glia
https://www.readbyqxmd.com/read/29439122/iron-insensitive-quantitative-assessment-of-subcortical-gray-matter-demyelination-in-multiple-sclerosis-using-the-macromolecular-proton-fraction
#16
V L Yarnykh, E P Krutenkova, G Aitmagambetova, P Repovic, A Mayadev, P Qian, L K Jung Henson, B Gangadharan, J D Bowen
BACKGROUND AND PURPOSE: Fast macromolecular proton fraction mapping is a recent quantitative MR imaging method for myelin assessment. The objectives of this study were to evaluate the macromolecular proton fraction as a measure of demyelination in subcortical GM structures in multiple sclerosis and assess a potential relationship between demyelination and excess iron deposition using the macromolecular proton fraction and T2* mapping. MATERIALS AND METHODS: Macromolecular proton fraction and T2* maps were obtained from 12 healthy controls, 18 patients with relapsing-remitting MS, and 12 patients with secondary-progressive MS using 3T MR imaging...
April 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29396631/fractional-anisotropy-of-white-matter-disability-and-blood-iron-parameters-in-multiple-sclerosis
#17
Estelle Herbert, Penelope Engel-Hills, Coenraad Hattingh, Jean-Paul Fouche, Martin Kidd, Christine Lochner, Maritha J Kotze, Susan J van Rensburg
Multiple sclerosis (MS) is a disorder related to myelin damage, which can be investigated by neuroimaging techniques such as fractional anisotropy (FA), a measure of microstructural white matter properties. The objectives of this study were to investigate (1) the relationship between FA and disability using an extremes of outcome approach, and (2) whether blood iron parameters were associated with FA and/or disability. Patients diagnosed with MS (n = 107; 14 males and 93 females) had iron parameter tests and disability determinations using the Expanded Disability Status Scale (EDSS)...
April 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29371258/quantitative-susceptibility-mapping-of-the-thalamus-relationships-with-thalamic-volume-total-gray-matter-volume-and-t2-lesion-burden
#18
G C Chiang, J Hu, E Morris, Y Wang, S A Gauthier
BACKGROUND AND PURPOSE: Both thalamic iron deposition and atrophy have been reported in patients with multiple sclerosis compared with healthy controls, but how they are related is unclear. The purpose of this study was to understand the pathophysiologic basis for this iron deposition. MATERIALS AND METHODS: Ninety-five patients with relapsing-remitting multiple sclerosis underwent 3T MR imaging with a standardized protocol that included quantitative susceptibility mapping to measure iron concentration and a 3D T1 echo-spoiled gradient-echo sequence to obtain thalamic volumes...
January 25, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29318974/-understanding-the-role-of-hypoxia-inducible-factor-during-neurodegeneration-for-new-therapeutics-opportunities
#19
Amalia Merelli, Julio Cesar Garcia Rodriguez, Jaume Folch, Marcelo R Regueiro, Antoni Camins, Alberto Lazarowski
Neurodegeneration (NDG) is linked with the progressive loss of neural function with intellectual and/or motor impairment. Several diseases affecting older individuals, including Alzheimer's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Parkinson's disease, stroke, Multiple Sclerosis and many others, are the most relevant disorders associated with NDG. Since other pathologies such as refractory epilepsy, brain infections, or hereditary diseases such as "neurodegeneration with brain iron accumulation", also lead to chronic brain inflammation with loss of neural cells, NDG can be said to affect all ages...
January 10, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29299614/cortical-and-subcortical-morphometric-and-iron-changes-in-relapsing-remitting-multiple-sclerosis-and-their-association-with-white-matter-t2-lesion-load-a-3-tesla-magnetic-resonance-imaging-study
#20
Ali Al-Radaideh, Imad Athamneh, Hadeel Alabadi, Majed Hbahbih
INTRODUCTION: This study was carried out to investigate the global and regional morphometric and iron changes in grey matter (GM) of multiple sclerosis (MS) patients and link them to the white matter (WM) lesions in a multimodal magnetic resonance imaging approach. MATERIAL AND METHODS: The study involved 30 relapsing-remitting MS (RRMS) patients along with 30 age-matched healthy controls (HC) who were scanned on a 3T Siemens Trio system. The scanning protocol included a 3D, high resolution T1, T2, and T2*-weighted sequences...
January 3, 2018: Clinical Neuroradiology
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