keyword
https://read.qxmd.com/read/38419028/lass2-suppresses-metastasis-in-multiple-cancers-by-regulating-the-ferroptosis-signalling-pathway-through-interaction-with-tfrc
#21
JOURNAL ARTICLE
Yunfei Huang, Jie Du, Dan Li, Wei He, Zhouheng Liu, Li Liu, Xiaoli Yang, Xiaoming Cheng, Rui Chen, Yan Yang
BACKGROUND: As a key enzyme in ceramide synthesis, longevity assurance homologue 2 (LASS2) has been indicated to act as a tumour suppressor in a variety of cancers. Ferroptosis is involved in a variety of tumour processes; however, the role of LASS2 in regulating ferroptosis has yet to be explored. This article explores the potential underlying mechanisms involved. METHODS: Bioinformatics tools and immunohistochemical staining were used to evaluate LASS2 expression, and the results were analysed in relation to overall survival and clinical association in multiple cancers...
February 28, 2024: Cancer Cell International
https://read.qxmd.com/read/38415132/radiomics-derived-from-t2-flair-the-value-of-2-and-3-classification-tasks-for-different-lesions-in-multiple-sclerosis
#22
JOURNAL ARTICLE
Zhuowei Shi, Yuqi Ma, Shuang Ding, Zichun Yan, Qiyuan Zhu, Hailing Xiong, Chuan Li, Yuhui Xu, Zeyun Tan, Feiyue Yin, Shanxiong Chen, Yongmei Li
BACKGROUND: White matter (WM) lesions can be classified into contrast enhancement lesions (CELs), iron rim lesions (IRLs), and non-iron rim lesions (NIRLs) based on different pathological mechanism in relapsing-remitting multiple sclerosis (RRMS). The application of radiomics established by T2-FLAIR to classify WM lesions in RRMS is limited, especially for 3-class classification among CELs, IRLs, and NIRLs. METHODS: A total of 875 WM lesions (92 CELs, 367 IRLs, 416 NIRLs) were included in this study...
February 1, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38414372/barriers-facilitators-of-iron-and-folic-acid-supplementation-and-deworming-program-among-school-going-adolescents-of-deoghar-jharkhand-india-a-mixed-methods-study
#23
JOURNAL ARTICLE
Bijit Biswas, Anuradha Gautam, G Jahnavi, Pratima Gupta, Saurabh Varshney
BACKGROUND: This study aimed to identify barriers and facilitators of iron and folic acid supplementation and deworming programs among school-going adolescents. METHODS: A mixed-method observational study was conducted among adolescents in the 8th to 10th standards and their teachers across four schools in Deoghar, Jharkhand, India, using simple random sampling. The study included a questionnaire on socio-demographics, knowledge (34 items) (α=0.894), attitudes (2 items) (α=0...
February 28, 2024: Korean Journal of Family Medicine
https://read.qxmd.com/read/38412721/regulating-the-interface-electron-distribution-of-iron-based-mofs-through-ligand-functionalization-enables-efficient-peroxymonosulfate-utilization-and-catalytic-performance
#24
JOURNAL ARTICLE
Yuwei Xue, Ran Gao, Shuangjie Lin, Qing Zhong, Qian Zhang, Junming Hong
Ligand functionalization is an effective way to endow Metal-organic frameworks (MOF) with versatility for multiple applications by introducing or displaying substituents without changing the origin framework. In this work, the original MIL-101(Fe) was modified by functional groups, including -NH2 , -NO2 , -CH3 , and -Cl substituents. The Bader charge results and electron localization function (ELF) quantitatively indicated that the functional ligands with different properties can regulate the electron structure of transition-metal centers through interface-charge redistribution...
February 17, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38411019/aluminum-and-other-chemical-elements-in-parenteral-nutrition-components-and-all-in-one-admixtures
#25
JOURNAL ARTICLE
Katja A Schönenberger, Christoph Saxer, Peter J Neyer, Valentina V Huwiler, Emilie Reber, Angelika Hammerer-Lercher, Zeno Stanga, Stefan Mühlebach
BACKGROUND & AIMS: Parenteral nutrition (PN) can lead to high or even toxic exposure to aluminum (Al). We aimed to quantify concentrations of Al and other chemical elements of all-in-one (AIO) PN admixtures for adults prepared from commercial multichamber bags (Olimel® 5.7%, Omegaflex® special, SmofKabiven®, all with and without electrolytes) and vitamin and trace element additives over a 48-h period. Secondly, we determined the level of Al contamination resulting from admixing and infusion set use...
December 2023: Clinical Nutrition
https://read.qxmd.com/read/38410113/exploration-of-potential-biomarkers-for-early-bladder-cancer-based-on-urine-proteomics
#26
JOURNAL ARTICLE
Xu Zhou, Fei Xue, Tingmiao Li, Jiangshan Xue, Siqi Yue, Shujie Zhao, Hezhen Lu, Chengyan He
BACKGROUND: Bladder cancer is a common malignant tumor of the urinary system. The progression of the condition is associated with a poor prognosis, so it is necessary to identify new biomarkers to improve the diagnostic rate of bladder cancer. METHODS: In this study, 338 urine samples (144 bladder cancer, 123 healthy control, 32 cystitis, and 39 upper urinary tract cancer samples) were collected, among which 238 samples (discovery group) were analyzed by LC-MS. The urinary proteome characteristics of each group were compared with those of bladder cancer, and the differential proteins were defined by bioinformatics analysis...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38406648/-will-i-be-able-to-be-myself-or-will-i-be-forced-to-lie-all-the-time-how-trans-and-non-binary-students-balance-professionalism-authenticity-and-safety-in-canadian-medical-programs
#27
JOURNAL ARTICLE
Kat Butler, Meredith Vanstone, Adryen Yak, Albina Veltman
INTRODUCTION: Promoting the inclusion of trans and non-binary (TNB) medical trainees is a key step in building an inclusive health workforce well-positioned to provide high-quality healthcare to all patients. Existing data on the experiences of TNB physicians and trainees describe widespread challenges related to prejudice and discrimination, with most trainees concealing their gender identity for fear of discrimination. We aimed to understand how TNB medical students have experienced professionalism and professional identity formation...
2024: Perspectives on Medical Education
https://read.qxmd.com/read/38405514/design-synthesis-and-evaluation-of-novel-magnetic-nanoparticles-combined-with-thiophene-derivatives-for-the-removal-of-cr-vi-from-an-aqueous-solution
#28
JOURNAL ARTICLE
Seham S Alterary, Monirah A Al-Alshaikh, Athar M Elhadi, Wenjie Cao
Most heavy metals are harmful to human health and the environment, even at extremely low concentrations. In natural waters, they are usually found only in trace amounts. Researchers are paying great attention to nanotechnology and nanomaterials as viable solutions to the problem of water pollution. This research focuses on the synthesis of organic thiophene derivatives that can be used as grafted ligands on the surface of silica-coated iron oxide nanoparticles to remove Cr(VI) chromium ions from water. The Vilsmeier-Haack reaction allows the formation of aldehyde groups in thiophene derivatives, and the resulting products were characterized by the FT-IR, NMR, and GC-MS...
February 20, 2024: ACS Omega
https://read.qxmd.com/read/38395553/an-investigation-into-the-effects-of-various-processing-methods-on-the-characteristic-compounds-of-highland-barley-using-a-widely-targeted-metabolomics-approach
#29
JOURNAL ARTICLE
Xijuan Yang, Wengang Zhang, Yongli Lan, Jie Zhang, Wancai Zheng, Jing Wu, Chengping Zhang, Bin Dang
This study explored the influence of diverse processing methods (cooking (CO), extrusion puffing (EX), and steam explosion puffing (SE), stir-frying (SF) and fermentation (FE)) on highland barley (Qingke) chemical composition using UHPLC-MS/MS based widely targeted metabolomics. Overall, 827 metabolites were identified and categorized into 16 classes, encompassing secondary metabolites, amino acids, nucleotides, lipids, etc. There 43, 85, 131, 51 and 98 differential metabolites were respectively selected from five comparative groups (raw materials (RM) vs CO/EX/SE/SF/FE), mainly involved in amino acids, nucleotides, flavonoids, and alkaloids...
March 2024: Food Research International
https://read.qxmd.com/read/38395547/assessment-of-the-effect-of-drying-on-brassica-greens-via-a-multiplex-approach-based-on-lc-qtof-ms-ms-molecular-networking-and-chemometrics-along-with-their-antioxidant-and-anticancer-activities
#30
JOURNAL ARTICLE
Mohammed N A Khalil, Sherif M Afifi, Basma M Eltanany, Laura Pont, Fernando Benavente, Sawsan M El-Sonbaty, Mohamed S Sedeek
Turnip (Brassica rapa var rapa L.) leaves are a rich source of versatile bioactive phytochemicals with great potential in the food and herbal industries. However, the effect of drying on its constituents has never been studied before. Hereto, three drying techniques were compared, namely, lyophilization (LY), vacuum oven (VO), and shade drying (SD). Chemical profiling utilizing liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (LC-QTOF-MS/MS) combined with chemometrics showed the different impacts of the drying methods on the phytochemical composition of the alcoholic leaf extracts...
March 2024: Food Research International
https://read.qxmd.com/read/38394733/xanthohumol-ameliorates-drug-induced-hepatic-ferroptosis-via-activating-nrf2-xct-gpx4-signaling-pathway
#31
JOURNAL ARTICLE
Yanyan Deng, Xiayan Chu, Qian Li, Guanghao Zhu, Jing Hu, Jianming Sun, Hairong Zeng, Jian Huang, Guangbo Ge
BACKGROUND: As a canonical iron-dependent form of regulated cell death (RCD), ferroptosis plays a crucial role in chemical-induced liver injuries. Previous studies have demonstrated that xanthohumol (Xh), a natural prenylflavonoid isolated from hops, exhibits anti-inflammatory, anti-antioxidative and hepatoprotective properties. However, the regulatory effects of Xh on hepatic ferroptosis and the underlying mechanism have not yet been fully elucidated. PURPOSE: To investigate the hepatoprotective effects of Xh against drug-induced liver injury (DILI) and the regulatory effects of Xh on hepatic ferroptosis, as well as to reveal the underlying molecular mechanisms...
February 22, 2024: Phytomedicine
https://read.qxmd.com/read/38392632/associations-between-mediterranean-diet-adherence-quality-of-life-and-mental-health-in-patients-with-multiple-sclerosis-a-cross-sectional-study
#32
JOURNAL ARTICLE
Antonios Dakanalis, Christina Tryfonos, Eleni Pavlidou, Konstantinos Vadikolias, Sousana K Papadopoulou, Olga Alexatou, Theofanis Vorvolakos, Maria Chrysafi, Dimitrios Fotiou, Maria Mentzelou, Aspasia Serdari, Maria Chatzidimitriou, Sophia Dimoliani, Gerasimos Tsourouflis, Constantinos Giaginis
BACKGROUND: The Mediterranean diet (MD) is well-known as a diet which may exert a protective effect against neurodegenerative diseases, including multiple sclerosis (MS). To date, only a few clinical surveys have assessed the potential effects of the MD in patients with MS. The purpose of the present study is to evaluate the potential effects of MD compliance on disease disability, quality of life, physical activity, depressive symptomatology, and blood biochemical parameters related to nutritional status in MS patients, considering several socio-demographic, anthropometric, and lifestyle characteristics...
February 11, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38388751/quercetin-alleviates-perimenopausal-depression-induced-by-ovariectomy-combined-with-chronic-unpredictable-mild-stress-through-regulating-serum-elements-and-inhibiting-ferroptosis-in-prefrontal-cortex-of-rats
#33
JOURNAL ARTICLE
Dan Wang, Jing Wang, Ziran Yu, Ranqi Yao, Jingnan Zhang, Xiujuan Zhao
This study investigated the effects of quercetin on the alterations of serum elements in perimenopausal depression rat model induced by ovariectomy combined with chronic unpredictable mild stress (OVX-CUMS) and possible mechanisms. According to the results of the sucrose preference test, the rats were randomly assigned to four groups: sham, OVX-CUMS, OVX-CUMS + 17β-estradiol (17β-estradiol: 0.27 mg/kg.bw), and OVX-CUMS + Quercetin (Quercetin: 50 mg/kg.bw). At the end of experiment, serum and prefrontal cortex of rats were collected...
February 22, 2024: Biological Trace Element Research
https://read.qxmd.com/read/38385246/carbon-fate-iron-dissolution-and-molecular-characterization-of-dissolved-organic-matter-in-thawed-yedoma-permafrost-under-varying-redox-conditions
#34
JOURNAL ARTICLE
Matheus Sampaio Carneiro Barreto, Rucha P Wani, Aleksandar I Goranov, Tyler D Sowers, Matthew Fischel, Thomas Alexander Douglas, Patrick G Hatcher, Donald L Sparks
Permafrost soils store ∼50% of terrestrial C, with Yedoma permafrost containing ∼25% of the total C. Permafrost is undergoing degradation due to thawing, with potentially hazardous effects on landscape stability and water resources. Complicating ongoing efforts to project the ultimate fate of deep permafrost C is the poorly constrained role of the redox environment, Fe-minerals, and its redox-active phases, which may modulate organic C-abundance, composition, and reactivity through complexation and catalytic processes...
February 22, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38373058/coprecipitation-as-a-one-step-se-separation-for-determination-of-isotope-ratios-completed-with-revised-uncertainty-evaluation
#35
JOURNAL ARTICLE
Jakub Karasiński, Klaudia Tetfejer, Piotr Radziński, Andrii Tupys, Anna Gambin, Ewa Bulska, Ludwik Halicz
This study introduces a simplified purification method for analyzing 82 Se/78 Se isotope ratios in diverse natural samples using hydride generation MC-ICP-MS. Unlike the thiol resin method, which is time-consuming and sensitive to the concentrations of reagents used at individual stages, our proposed alternative is quicker, simpler, and robust. The procedure involves coprecipitation of selenium with iron hydroxide and dissolution in hydrochloric acid. Combining hydride generation and a second cleanup stage achieves sufficient purification for Se isotope ratio measurements...
February 19, 2024: Analytical Chemistry
https://read.qxmd.com/read/38367113/green-industry-work-production-of-fecl-3-from-iron-and-steel-industry-waste-mill-scale-and-its-use-in-wastewater-treatment
#36
JOURNAL ARTICLE
Alper Solmaz, Ömer Saltuk Bölükbaşi, Zeynel Abidin Sari
Mill scale (MS) is considered to be a significant metallurgical waste, but there is no economical method yet to utilize its metal content. In this study, which covers various processes in several stages, the solution of iron in MS, which is the Iron and Steel Industry (I&SI) waste, as FeCl3 (MS-FeCl3 ) in the thermoreactor in the presence of HCl, was investigated. In the next step, the conditions for using this solution as a coagulant in the treatment of I&SI wastewater were investigated using the jar test...
February 17, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38366920/paramagnetic-rim-lesions-predict-greater-long-term-relapse-rates-and-clinical-progression-over-10-years
#37
JOURNAL ARTICLE
Jack A Reeves, Maryam Mohebbi, Taylor Wicks, Fahad Salman, Alexander Bartnik, Dejan Jakimovski, Niels Bergsland, Ferdinand Schweser, Bianca Weinstock-Guttman, Michael G Dwyer, Robert Zivadinov
BACKGROUND: Paramagnetic rim lesions (PRLs) have been linked to higher clinical disease severity and relapse frequency. However, it remains unclear whether PRLs predict future, long-term disease progression. OBJECTIVES: The study aimed to assess whether baseline PRLs were associated with subsequent long-term (10 years) Expanded Disability Status Scale (EDSS) increase and relapse frequency and, if so, whether PRL-associated EDSS increase was mediated by relapse. METHODS: This retrospective analysis included 172 people with multiple sclerosis (pwMS) with 1868 yearly clinical visits over a mean follow-up time of 10...
February 17, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38363508/anti-dengue-potential-and-mosquitocidal-effect-of-marine-green-algae-stabilized-mn-doped-superparamagnetic-iron-oxide-nanoparticles-mn-spions-an-eco-friendly-approach
#38
JOURNAL ARTICLE
Rajapandian Rajaganesh, Kadarkarai Murugan
Vector-borne diseases pose a significant public health challenge in economically disadvantaged nations. Malaria, dengue fever, chikungunya, Zika, yellow fever, Japanese encephalitis, and lymphatic filariasis are spread by mosquitoes. Consequently, the most effective method of preventing these diseases is to eliminate the mosquito population. Historically, the majority of control programs have depended on chemical pesticides, including organochlorines, organophosphates, carbamates, and pyrethroids. Synthetic insecticides used to eradicate pests have the potential to contaminate groundwater, surface water, beneficial soil organisms, and non-target species...
February 16, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38361717/posterior-reversible-encephalopathy-syndrome-pres-and-the-uncommon-sequela-mesial-temporal-sclerosis
#39
Abraham Mengstu, Mathew N Chakko, Blake Salisbury, Jibran Fateh
Posterior reversible encephalopathy syndrome is often linked to conditions like hypertension and is characterized by reversible brain edema. The development of mesial temporal sclerosis as a consequence of posterior reversible encephalopathy syndrome is an uncommon clinical outcome.  We report a 48-year-old female who initially presented with severe iron deficiency anemia, hypertension, and septic tenosynovitis requiring surgical drainage with subsequent development of posterior reversible encephalopathy syndrome accompanied by endocarditis...
January 2024: Curēus
https://read.qxmd.com/read/38359492/the-association-between-trace-metals-in-both-cancerous-and-non-cancerous-tissues-with-the-risk-of-liver-and-gastric-cancer-progression-in-northwest-china
#40
JOURNAL ARTICLE
Jun Yan, Honglong Zhang, Mingtong Zhang, Meng Tian, Guole Nie, Danna Xie, Xingwang Zhu, Xun Li
Liver cancer and gastric cancer have extremely high morbidity and mortality rates worldwide. It is well known that an increase or decrease in trace metals may be associated with the formation and development of a variety of diseases, including cancer. Therefore, this study aimed to evaluate the contents of aluminium (Al), arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), manganese (Mn), nickel (Ni), lead (Pb), selenium (Se), and zinc (Zn) in cancerous liver and gastric tissues, compared to adjacent healthy tissues, and to investigate the relationship between trace metals and cancer progression...
February 7, 2024: Journal of Pharmaceutical and Biomedical Analysis
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