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https://www.readbyqxmd.com/read/29343241/clinical-features-and-dysfunctions-of-iron-metabolism-in-parkinson-disease-patients-with-hyper-echogenicity-in-substantia-nigra-a-cross-sectional-study
#1
Shu-Yang Yu, Chen-Jie Cao, Li-Jun Zuo, Ze-Jie Chen, Teng-Hong Lian, Fang Wang, Yang Hu, Ying-Shan Piao, Li-Xia Li, Peng Guo, Li Liu, Qiu-Jin Yu, Rui-Dan Wang, Piu Chan, Sheng-di Chen, Xiao-Min Wang, Wei Zhang
BACKGROUND: Transcranial ultrasound is a useful tool for providing the evidences for the early diagnosis and differential diagnosis of Parkinson disease (PD). However, the relationship between hyper echogenicity in substantia nigra (SN) and clinical symptoms of PD patients remains unknown, and the role of dysfunction of iron metabolism on the pathogenesis of SN hyper echogenicity is unclear. METHODS: PD patients was detected by transcranial sonography and divided into with no hyper echogenicity (PDSN-) group and with hyper echogenicity (PDSN+) group...
January 17, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29335875/seasonal-variation-and-source-apportionment-of-pm2-5-bound-trace-elements-at-a-coastal-area-in-southwestern-taiwan
#2
Su-Lun Hwang, Miao-Ching Chi, Su-Er Guo, Yu-Ching Lin, Chiang-Ting Chou, Chieh-Mo Lin
The aim of this study is to investigate the seasonal variations and source apportionment on atmospheric fine particulate matter (PM2.5) mass and associated trace element concentrations at a coastal area, in Chiayi County of southwestern Taiwan. Particle measurements were conducted in 2015. Twenty-three trace elements in PM2.5 were analyzed using inductively coupled plasma mass spectrometry (ICP-MS). Multiple approaches of the enrichment factor (EF) analysis and positive matrix fraction (PMF) model were used to identify potential sources of PM2...
January 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29328981/a-simple-lc-ms-ms-method-for-determination-of-deferasirox-in-human-plasma-troubleshooting-of-interference-from-ferric-ion-in-method-development-and-its-application
#3
Tengfei Li, Zhimin Cui, Yan Wang, Wen Yang, Duo Li, QinXin Song, Luning Sun, Li Ding
As an orally active iron chelator, deferasirox forms its ion complexes in the prepared plasma samples and LC-MS mobile phase where ferric ion exists, and then comparing with the nominal concentration level, a lower detected concentration level of deferasirox would be obtained after LC-MS analysis, if no proper treatment was adopted. Meanwhile, the phenomenon would be observed that multiple repeat injections of the same deferasirox plasma sample in the same tube would show the lower and lower detected concentration levels of deferasirox, which caused by more and more ferric ions from the injection needle dissolved in the sample solution as multiple repeated injections...
December 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29328635/adsorption-and-molecular-fractionation-of-dissolved-organic-matter-on-iron-bearing-mineral-matrices-of-varying-crystallinity
#4
Elizabeth K Coward, Tsutomu Ohno, Alain F Plante
Iron (Fe)-bearing mineral phases contribute disproportionately to adsorption of soil organic matter (SOM), due to their elevated chemical reactivity and specific surface area (SSA). However, the spectrum of Fe solid-phase speciation present in oxidation-reduction-active soils challenges analysis of SOM-mineral interactions and may induce differential molecular fractionation of dissolved organic matter (DOM). This work used paired selective dissolution experiments and batch sorption of post-extraction residues to 1) quantify the contributions of Fe-bearing minerals of varying crystallinity to DOM sorption, and 2) characterize molecular fractionation using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS)...
January 12, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29327191/iron-impregnated-zeolite-catalyst-for-efficient-removal-of-micropollutants-at-very-low-concentration-from-meurthe-river
#5
Hawraa Ayoub, Thibault Roques-Carmes, Olivier Potier, Bachar Koubaissy, Steve Pontvianne, Audrey Lenouvel, Cédric Guignard, Emmanuel Mousset, Hélène Poirot, Joumana Toufaily, Tayssir Hamieh
In this paper, for the first time, faujasite Y zeolite impregnated with iron (III) was employed as a catalyst to remove a real cocktail of micropollutants inside real water samples from the Meurthe river by the means of the heterogeneous photo-Fenton process. The catalyst was prepared by the wet impregnation method using iron (III) nitrate nonahydrate as iron precursor. First, an optimization of the process parameters was conducted using phenol as model macro-pollutant. The hydrogen peroxide concentration, the light wavelength (UV and visible) and intensity, the iron loading immobilized, as well as the pH of the solution were investigated...
January 11, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29314215/simultaneous-quantitative-susceptibility-mapping-qsm-and-r2-for-high-iron-concentration-quantification-with-3d-ultrashort-echo-time-sequences-an-echo-dependence-study
#6
Xing Lu, Yajun Ma, Eric Y Chang, Qun He, Adam Searleman, Annette von Drygalski, Jiang Du
PURPOSE: To evaluate the echo dependence of 3D ultrashort echo time (TE) quantitative susceptibility mapping (3D UTE-QSM) and effective transverse relaxation rate ( R2*) measurement in the setting of high concentrations of iron oxide nanoparticles. METHODS: A phantom study with iron concentrations ranging from 2 to 22 mM was performed using a 3D UTE Cones sequence. Simultaneous QSM processing with morphology-enabled dipole inversion (MEDI) and R2* single exponential fitting was conducted offline with the acquired 3D UTE data...
January 4, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29303599/proteomic-analysis-of-peroxynitrite-induced-protein-nitration-in-isolated-beef-heart-mitochondria
#7
M Kohutiar, A Eckhardt, I Mikšík, P Šantorová, J Wilhelm
Mitochondria are exposed to reactive nitrogen species under physiological conditions and even more under several pathologic states. In order to reveal the mechanism of these processes we studied the effects of peroxynitrite on isolated beef heart mitochondria in vitro. Peroxynitrite has the potential to nitrate protein tyrosine moieties, break the peptide bond, and eventually release the membrane proteins into the solution. All these effects were found in our experiments. Mitochondrial proteins were resolved by 2D electrophoresis and the protein nitration was detected by immunochemical methods and by nano LC-MS/MS...
January 5, 2018: Physiological Research
https://www.readbyqxmd.com/read/29301078/molecular-chemodiversity-of-dissolved-organic-matter-in-paddy-soils
#8
Xiaoming Li, Guo-Xin Sun, Songcan Chen, Zhi Fang, Hai-Yan Yuan, Quan Shi, Yong-Guan Zhu
Organic matter (OM), and dissolved organic matter (DOM), have a major influence upon biogeochemical processes; most significantly, the carbon cycle. To date, very few studies have examined the spatial heterogeneity of DOM in paddy soils. Thus, very little is known about the DOM molecular profiles and the key environmental factors that underpin DOM molecular chemodiversity in paddy soils. Here, Fourier-Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR MS) was applied to unambiguously resolve 11,361 molecular formulae in 16 paddy soils; thereby elucidating the molecular characteristics of paddy soil DOM...
January 4, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29299614/cortical-and-subcortical-morphometric-and-iron-changes-in-relapsing-remitting-multiple-sclerosis-and-their-association-with-white-matter-t2%C3%A2-lesion-load-a%C3%A2-3-tesla-magnetic-resonance-imaging-study
#9
Ali Al-Radaideh, Imad Athamneh, Hadeel Alabadi, Majed Hbahbih
INTRODUCTION: This study was carried out to investigate the global and regional morphometric and iron changes in grey matter (GM) of multiple sclerosis (MS) patients and link them to the white matter (WM) lesions in a multimodal magnetic resonance imaging approach. MATERIAL AND METHODS: The study involved 30 relapsing-remitting MS (RRMS) patients along with 30 age-matched healthy controls (HC) who were scanned on a 3T Siemens Trio system. The scanning protocol included a 3D, high resolution T1, T2, and T2*-weighted sequences...
January 3, 2018: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29291520/iron-iii-phthalocyanine-supported-on-a-spongin-scaffold-as-an-advanced-photocatalyst-in-a-highly-efficient-removal-process-of-halophenols-and-bisphenol-a
#10
Małgorzata Norman, Sonia Żółtowska-Aksamitowska, Agnieszka Zgoła-Grześkowiak, Hermann Ehrlich, Teofil Jesionowski
This study investigated for the first time the degradation of phenol, chlorophenol, fluorophenol and bisphenol A (BPA) by the novel iron phthalocyanine/spongin hybrid material under various process conditions: hydrogen peroxide and UV irradiation. The heterogeneous catalyst, iron phthalocyanine/spongin (SFe), was produced by an adsorption process. The product obtained was investigated by a variety of spectroscopic techniques - X-ray photoelectron spectroscopy (XPS), energy-dispersive X-ray spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR) and carbon-13 nuclear magnetic resonance (13C NMR) - as well as elemental and thermal analysis...
December 23, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29290806/multimodal-theranostic-nanoformulations-permit-magnetic-resonance-bioimaging-of-antiretroviral-drug-particle-tissue-cell-biodistribution
#11
Bhavesh D Kevadiya, Christopher Woldstad, Brendan M Ottemann, Prasanta Dash, Balasrinivasa R Sajja, Benjamin Lamberty, Brenda Morsey, Ted Kocher, Rinku Dutta, Aditya N Bade, Yutong Liu, Shannon E Callen, Howard S Fox, Siddappa N Byrareddy, JoEllyn M McMillan, Tatiana K Bronich, Benson J Edagwa, Michael D Boska, Howard E Gendelman
RATIONALE: Long-acting slow effective release antiretroviral therapy (LASER ART) was developed to improve patient regimen adherence, prevent new infections, and facilitate drug delivery to human immunodeficiency virus cell and tissue reservoirs. In an effort to facilitate LASER ART development, "multimodal imaging theranostic nanoprobes" were created. These allow combined bioimaging, drug pharmacokinetics and tissue biodistribution tests in animal models. METHODS: Europium (Eu3+)- doped cobalt ferrite (CF) dolutegravir (DTG)- loaded (EuCF-DTG) nanoparticles were synthesized then fully characterized based on their size, shape and stability...
2018: Theranostics
https://www.readbyqxmd.com/read/29283393/comparative-evaluation-of-u-s-brand-and-generic-intravenous-sodium-ferric-gluconate-complex-in-sucrose-injection-biodistribution-after-intravenous-dosing-in-rats
#12
Christopher R Beekman, Murali Matta, Christopher D Thomas, Adil Mohammad, Sharron Stewart, Lin Xu, Ashok Chockalingam, Katherine Shea, Dajun Sun, Wenlei Jiang, Vikram Patel, Rodney Rouse
Relative biodistribution of FDA-approved innovator and generic sodium ferric gluconate (SFG) drug products was investigated to identify differences in tissue distribution of iron after intravenous dosing to rats. Three equal cohorts of 42 male Sprague-Dawley rats were created with each cohort receiving one of three treatments: (1) the innovator SFG product dosed intravenously at a concentration of 40 mg/kg; (2) the generic SFG product dosed intravenously at a concentration of 40 mg/kg; (3) saline dosed intravenously at equivalent volume to SFG products...
December 28, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29278827/a-resistive-q-switch-for-low-field-nmr-systems
#13
J Z Zhen, K T O'Neill, E O Fridjonsson, P L Stanwix, M L Johns
An NMR Q-switch was designed and constructed specifically for use with low-field NMR apparatus. This featured a comparatively simple resistive damping design. It served to reduce the r.f. probe ring-down time, and hence reduced the signal acquisition delay from 25 ms to 9 ms, on an Earth's magnetic field NMR system. The advantage of this earlier acquisition was demonstrated for both an aqueous suspension of iron oxide particles and using an NMR flow meter.
December 8, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29260576/quantification-of-pancreatic-fat-with-dual-echo-imaging-at-3-0-t-mr-in-clinical-application-how-do-the-corrections-for-t1-and-t2-relaxation-effect-work-and-simplified-correction-strategy
#14
Fang Yuan, Bin Song, Zixing Huang, Chunchao Xia, Xijiao Liu
Background Dual-echo imaging is a routine clinical magnetic resonance (MR) sequence affected by T1 and T2* relaxation effect in fat quantification. The separate impacts of T1 and T2* relaxation effect in pancreatic fat quantification using dual-echo imaging at 3.0-T MR have not been reported in detail. Purpose To demonstrate the separate T1 and T2* relaxation effect on pancreatic fat quantification by dual-echo imaging at 3.0-T MR and the simplified correction strategy is discussed for convenient clinical application...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29259169/systematic-screening-of-generic-drugs-for-progressive-multiple-sclerosis-identifies-clomipramine-as-a-promising-therapeutic
#15
Simon Faissner, Manoj Mishra, Deepak K Kaushik, Jianxiong Wang, Yan Fan, Claudia Silva, Gail Rauw, Luanne Metz, Marcus Koch, V Wee Yong
The treatment of progressive multiple sclerosis (MS) is unsatisfactory. One reason is that the drivers of disease, which include iron-mediated neurotoxicity, lymphocyte activity, and oxidative stress, are not simultaneously targeted. Here we present a systematic screen to identify generic, orally available medications that target features of progressive MS. Of 249 medications that cross the blood-brain barrier, 35 prevent iron-mediated neurotoxicity in culture. Of these, several antipsychotics and antidepressants strongly reduce T-cell proliferation and oxidative stress...
December 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29247140/genetic-dissection-of-cyclic-pyranopterin-monophosphate-biosynthesis-in-plant-mitochondria
#16
Inga Kruse, Andrew Maclean, Lionel Hill, Janneke Balk
Mitochondria play a key role in the biosynthesis of two metal cofactors, iron-sulfur (FeS) clusters and molybdenum cofactor (Moco). The two pathways intersect at several points, but a scarcity of mutants has hindered studies to better understand these links. We screened a collection of sirtinol-resistant Arabidopsis thaliana mutants for lines with decreased activities of cytosolic FeS enzymes and Moco enzymes. We identified a new mutant allele of ATM3 , encoding the ATP-binding cassette Transporter of the Mitochondria 3 (systematic name ABCB25), confirming the previously reported role of ATM3 in both FeS cluster and Moco biosynthesis...
December 15, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29242359/combining-quantitative-susceptibility-mapping-with-automatic-zero-reference-qsm0-and-myelin-water-fraction-imaging-to-quantify-iron-related-myelin-damage-in-chronic-active-ms-lesions
#17
Y Yao, T D Nguyen, S Pandya, Y Zhang, S Hurtado Rúa, I Kovanlikaya, A Kuceyeski, Z Liu, Y Wang, S A Gauthier
BACKGROUND AND PURPOSE: A hyperintense rim on susceptibility in chronic MS lesions is consistent with iron deposition, and the purpose of this study was to quantify iron-related myelin damage within these lesions as compared with those without rim. MATERIALS AND METHODS: Forty-six patients had 2 longitudinal quantitative susceptibility mapping with automatic zero reference scans with a mean interval of 28.9 ± 11.4 months. Myelin water fraction mapping by using fast acquisition with spiral trajectory and T2 prep was obtained at the second time point to measure myelin damage...
December 14, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29232402/chagas-disease-vector-blood-meal-sources-identified-by-protein-mass-spectrometry
#18
Judith I Keller, Bryan A Ballif, Riley M St Clair, James J Vincent, M Carlota Monroy, Lori Stevens
Chagas disease is a complex vector borne parasitic disease involving blood feeding Triatominae (Hemiptera: Reduviidae) insects, also known as kissing bugs, and the vertebrates they feed on. This disease has tremendous impacts on millions of people and is a global health problem. The etiological agent of Chagas disease, Trypanosoma cruzi (Kinetoplastea: Trypanosomatida: Trypanosomatidae), is deposited on the mammalian host in the insect's feces during a blood meal, and enters the host's blood stream through mucous membranes or a break in the skin...
2017: PloS One
https://www.readbyqxmd.com/read/29228768/recovery-of-mrs3%C3%AE-mrs4%C3%AE-saccharomyces-cerevisiae-cells-under-iron-sufficient-conditions-and-the-role-of-fe580
#19
Michael J Moore, Joshua Wofford, Andrew Dancis, Paul Alan Lindahl
Mrs3 and Mrs4 are mitochondrial inner membrane proteins that deliver an unidentified cytosolic iron species into the matrix for use in iron-sulfur-cluster (ISC) and heme biosynthesis. The Mrs3/4 double-deletion strain (ΔΔ) grew slowly in iron-deficient glycerol/ethanol medium but recovered to WT rates in iron-sufficient medium. ΔΔ cells grown under both iron-deficient and iron-sufficient respiring conditions accumulated large amounts of iron relative to WT cells, indicating iron homeostatic dysregulation regardless of nutrient iron status...
December 11, 2017: Biochemistry
https://www.readbyqxmd.com/read/29214234/magnetic-sensing-potential-of-fe3o4-nanocubes-exceeds-that-of-fe3o4-nanospheres
#20
Arati G Kolhatkar, Yi-Ting Chen, Pawilai Chinwangso, Ivan Nekrashevich, Gamage C Dannangoda, Ankit Singh, Andrew C Jamison, Oussama Zenasni, Irene A Rusakova, Karen S Martirosyan, Dmitri Litvinov, Shoujun Xu, Richard C Willson, T Randall Lee
This paper highlights the relation between the shape of iron oxide (Fe3O4) particles and their magnetic sensing ability. We synthesized Fe3O4 nanocubes and nanospheres having tunable sizes via solvothermal and thermal decomposition synthesis reactions, respectively, to obtain samples in which the volumes and body diagonals/diameters were equivalent. Vibrating sample magnetometry (VSM) data showed that the saturation magnetization (Ms) and coercivity of 100-225 nm cubic magnetic nanoparticles (MNPs) were, respectively, 1...
November 30, 2017: ACS Omega
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