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https://www.readbyqxmd.com/read/27908408/protective-effect-of-magnesium-acetyltaurate-against-nmda-induced-retinal-damage-involves-restoration-of-minerals-and-trace-elements-homeostasis
#1
Azliana Jusnida Ahmad Jafri, Natasha Najwa Nor Arfuzir, Lidawani Lambuk, Igor Iezhitsa, Renu Agarwal, Puneet Agarwal, Norhafiza Razali, Anna Krasilnikova, Maria Kharitonova, Vasily Demidov, Evgeny Serebryansky, Anatoly Skalny, Alexander Spasov, Ahmad Pauzi Md Yusof, Nafeeza Mohd Ismail
Glutamate-mediated excitotoxicity involving N-methyl-d-aspartate (NMDA) receptors has been recognized as a final common outcome in pathological conditions involving death of retinal ganglion cells (RGCs). Overstimulation of NMDA receptors results in influx of calcium (Ca) and sodium (Na) ions and efflux of potassium (K). NMDA receptors are blocked by magnesium (Mg). Such changes due to NMDA overstimulation are also associated with not only the altered levels of minerals but also that of trace elements and redox status...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27906525/the-clinical-utility-of-qsm-disease-diagnosis-medical-management-and-surgical-planning
#2
REVIEW
Sarah Eskreis-Winkler, Yan Zhang, Jingwei Zhang, Zhe Liu, Alexey Dimov, Ajay Gupta, Yi Wang
Quantitative susceptibility mapping (QSM) is an MR technique that depicts and quantifies magnetic susceptibility sources. Mapping iron, the dominant susceptibility source in the brain, has many important clinical applications. Herein, we review QSM applications in the diagnosis, medical management, and surgical treatment of disease. To assist in early disease diagnosis, QSM can identify elevated iron levels in the motor cortex of amyotrophic lateral sclerosis patients, in the substantia nigra of Parkinson's disease (PD) patients, in the globus pallidus, putamen, and caudate of Huntington's disease patients, and in the basal ganglia of Wilson's disease patients...
December 1, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27905613/unambiguous-identification-and-discovery-of-bacterial-siderophores-by-direct-injection-21-tesla-fourier-transform-ion-cyclotron-resonance-mass-spectrometry
#3
Lawrence R Walker, Malak M Tfaily, Jared B Shaw, Nancy J Hess, Ljiljana Paša-Tolić, David W Koppenaal
Under iron-limiting conditions, bacteria produce low molecular mass Fe(iii) binding molecules known as siderophores to sequester the Fe(iii), along with other elements, increasing their bioavailability. Siderophores are thought to influence iron cycling and biogeochemistry in both marine and terrestrial ecosystems and hence the need for rapid, confident characterization of these compounds has increased. In this study, the type of siderophores produced by two marine bacterial species, Synechococcus sp. PCC 7002 and Vibrio cyclitrophicus 1F53, were characterized by use of a newly developed 21 T Fourier Transform Ion Cyclotron Resonance Mass Spectrometer (FTICR MS) with direct injection electrospray ionization...
December 1, 2016: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/27894068/residual-myocardial-iron-following-intramyocardial-hemorrhage-during-the-convalescent-phase-of-reperfused-st-segment-elevation-myocardial-infarction-and-adverse-left-ventricular-remodeling
#4
Heerajnarain Bulluck, Stefania Rosmini, Amna Abdel-Gadir, Steven K White, Anish N Bhuva, Thomas A Treibel, Marianna Fontana, Manish Ramlall, Ashraf Hamarneh, Alex Sirker, Anna S Herrey, Charlotte Manisty, Derek M Yellon, Peter Kellman, James C Moon, Derek J Hausenloy
BACKGROUND: The presence of intramyocardial hemorrhage (IMH) in ST-segment-elevation myocardial infarction patients reperfused by primary percutaneous coronary intervention has been associated with residual myocardial iron at follow-up, and its impact on adverse left ventricular (LV) remodeling is incompletely understood and is investigated here. METHODS AND RESULTS: Forty-eight ST-segment-elevation myocardial infarction patients underwent cardiovascular magnetic resonance at 4±2 days post primary percutaneous coronary intervention, of whom 40 had a follow-up scan at 5±2 months...
October 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27876878/dependence-of-phase-configurations-microstructures-and-magnetic-properties-of-iron-nickel-fe-ni-alloy-nanoribbons-on-deoxidization-temperature-in-hydrogen
#5
Panpan Jing, Mengting Liu, Yongping Pu, Yongfei Cui, Zhuo Wang, Jianbo Wang, Qingfang Liu
Iron-nickel (Fe-Ni) alloy nanoribbons were reported for the first time by deoxidizing NiFe2O4 nanoribbons, which were synthesized through a handy route of electrospinning followed by air-annealing at 450 °C, in hydrogen (H2) at different temperatures. It was demonstrated that the phase configurations, microstructures and magnetic properties of the as-deoxidized samples closely depended upon the deoxidization temperature. The spinel NiFe2O4 ferrite of the precursor nanoribbons were firstly deoxidized into the body-centered cubic (bcc) Fe-Ni alloy and then transformed into the face-centered cubic (fcc) Fe-Ni alloy of the deoxidized samples with the temperature increasing...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27868112/uplc-ms-ms-investigation-of-%C3%AE-glucan-oligosaccharide-oxidation
#6
Samy Boulos, Laura Nyström
Polysaccharide degradation mediated by hydroxyl radicals (HO˙) or lytic monooxygenases (LPMOs) is relevant in various biological and industrial processes. Thereby, the Fenton-induced (H2O2/Fe(2+)) oxidation of mixed-linkage (1→3,1→4)-β-d-glucan (BG), a cereal dietary fibre with several well-established health promoting properties, shows potential for modulating BG functionality. The precise identification of oxidation products, however, is impeded by their diversity due to the indiscriminate nature of HO˙, the large molecular weight, and the corresponding low frequency of discrete alterations along the polymer chain...
November 21, 2016: Analyst
https://www.readbyqxmd.com/read/27867532/left-ventricular-ejection-fraction-recovery-in-patients-with-heart-failure-treated-with-intravenous-iron-a-pilot-study
#7
Julio Núñez, José Vicente Monmeneu, Anna Mollar, Eduardo Núñez, Vicent Bodí, Gema Miñana, Sergio García-Blas, Enrique Santas, Jaume Agüero, Francisco J Chorro, Juan Sanchis, Maria Pilar López-Lereu
AIMS: In patients with heart failure with reduced ejection fraction (HFrEF) and iron deficiency, treatment with intravenous iron has shown a clinical improvement regardless of anaemic status. Cardiac magnetic resonance (CMR) T2* sequence has shown a potential utility for evaluating myocardial iron deficiency. We aimed to evaluate whether T2* sequence significantly changes after ferric carboximaltose (FCM) administration, and if such changes correlate with changes in left ventricle ejection fraction (LVEF)...
December 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27855289/potential-contribution-of-the-hepcidin-macrophage-axis-to-plaque-vulnerability-in-acute-myocardial-infarction-in-human
#8
Masahiro Sasai, Yoshitaka Iso, Takuya Mizukami, Naohisa Tomosugi, Takeyuki Sambe, Akira Miyazaki, Hiroshi Suzuki
OBJECTIVES: Hepcidin-25 serves as a key peptide in the regulation of iron homeostasis and inflammation. It remains unknown whether hepcidin-25 plays an adverse role in atherosclerotic diseases. The aim of this study was to investigate whether hepcidin-25 is involved in the pathophysiology of coronary plaque vulnerability. METHODS AND RESULTS: Serum hepcidin-25 levels were quantitatively determined by the LC-MS/MS assay system. Peripheral blood was collected from patients with acute myocardial infarction (MI, n=33) and patients with stable angina pectoris (sCAD, n=19)...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27829982/new-insights-into-the-role-of-oxidative-stress-mechanisms-in-the-pathophysiology-and-treatment-of-multiple-sclerosis
#9
REVIEW
Bożena Adamczyk, Monika Adamczyk-Sowa
Multiple sclerosis (MS) is a multifactorial disease of the central nervous system (CNS) characterized by an inflammatory process and demyelination. The etiology of the disease is still not fully understood. Therefore, finding new etiological factors is of such crucial importance. It is suspected that the development of MS may be affected by oxidative stress (OS). In the acute phase OS initiates inflammatory processes and in the chronic phase it sustains neurodegeneration. Redox processes in MS are associated with mitochondrial dysfunction, dysregulation of axonal bioenergetics, iron accumulation in the brain, impaired oxidant/antioxidant balance, and OS memory...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27807790/magnetic-cobalt-ferrite-composite-as-an-efficient-catalyst-for-photocatalytic-oxidation-of-carbamazepine
#10
Yongzhen He, Chaomeng Dai, Xuefei Zhou
A magnetic spinel cobalt ferrite nanoparticle composite (CFO) was prepared via an ultrasonication-assisted co-precipitation method. The morphological structure and surface composition of CFO before and after reaction were investigated by using X-ray diffraction, scanning electron microscopy, transmission electron microscopy, energy dispersive X-ray, and Fourier transform infrared spectroscopy, indicating the consumption of iron oxide during photodegradation. X-ray photoelectron spectroscopy and vibrating sample magnetometry confirm the preparation of the ferrite nanoparticle composite and its magnetic properties...
November 3, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27796537/slow-expansion-of-multiple-sclerosis-iron-rim-lesions-pathology-and-7%C3%A2-t-magnetic-resonance-imaging
#11
Assunta Dal-Bianco, Günther Grabner, Claudia Kronnerwetter, Michael Weber, Romana Höftberger, Thomas Berger, Eduard Auff, Fritz Leutmezer, Siegfried Trattnig, Hans Lassmann, Francesca Bagnato, Simon Hametner
In multiple sclerosis (MS), iron accumulates inside activated microglia/macrophages at edges of some chronic demyelinated lesions, forming rims. In susceptibility-based magnetic resonance imaging at 7 T, iron-laden microglia/macrophages induce a rim of decreased signal at lesion edges and have been associated with slowly expanding lesions. We aimed to determine (1) what lesion types and stages are associated with iron accumulation at their edges, (2) what cells at the lesion edges accumulate iron and what is their activation status, (3) how reliably can iron accumulation at the lesion edge be detected by 7 T magnetic resonance imaging (MRI), and (4) if lesions with rims enlarge over time in vivo, when compared to lesions without rims...
October 27, 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/27777513/multi-omics-analysis-on-the-pathogenicity-of-enterobacter-cloacae-enhku01-isolated-from-sewage-outfalls-along-the-ningbo-coastline
#12
Dijun Zhang, Weina He, Qianqian Tong, Jun Zhou, Xiurong Su
BACKGROUND: The acquisition of iron is important for the pathogenicity of bacteria and blood. Three different culture environments (Fe stimulation, blood agar plate and normal plate) were used to stimulate Enterobacter cloacae, and their respective pathogenicities were compared at the proteomic, mRNA and metabolomic levels. METHODS: 2D-DIGE combined with MALDI-TOF-MS/MS, RT-PCR and (1)H NMR were used to analyze the differential expression levels of proteins, mRNA and metabolites...
2016: Proteome Science
https://www.readbyqxmd.com/read/27773261/heterogeneous-sono-fenton-like-process-using-martite-nanocatalyst-prepared-by-high-energy-planetary-ball-milling-for-treatment-of-a-textile-dye
#13
Mahsa Dindarsafa, Alireza Khataee, Baris Kaymak, Behrouz Vahid, Atefeh Karimi, Amir Rahmani
High energy planetary ball milling was applied to prepare sono-Fenton nanocatalyst from natural martite (NM). The NM samples were milled for 2-6h at the speed of 320rpm for production of various ball milled martite (BMM) samples. The catalytic performance of the BMMs was greater than the NM for treatment of Acid Blue 92 (AB92) in heterogeneous sono-Fenton-like process. The NM and the BMM samples were characterized by XRD, FT-IR, SEM, EDX and BET analyses. The particle size distribution of the 6h-milled martite (BMM3) was in the range of 10-90nm, which had the highest surface area compared to the other samples...
January 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27766631/pulmonary-dysfunction-in-thalassaemia-major-is-there-any-relationship-with-body-iron-stores
#14
Francesca Guidotti, Gioia Piatti, Alessia Marcon, Elena Cassinerio, Marianna Giuditta, Alberto Roghi, Valter Fasano, Dario Consonni, Maria Domenica Cappellini
Although pulmonary function abnormalities in thalassaemia major (TM) were described in 1980, the pathogenetic mechanism is not clear and data are contradictory, probably because of study heterogeneity and the multifactorial nature of the pathogenesis. We retrospectively analysed 73 adult TM patients to evaluate the prevalence of pulmonary dysfunction in adult TM and investigate relationships with iron load. All patients underwent body plethysmography and carbon monoxide diffusion (DLCO) was assessed in 63, in addition to blood tests, echocardiogram and T2* myocardial and liver magnetic resonance imaging...
October 21, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27766326/alkyl-grignard-cross-coupling-of-aryl-phosphates-catalyzed-by-new-highly-active-ionic-iron-ii-complexes-containing-a-phosphine-ligand-and-an-imidazolium-cation
#15
Zhuang Li, Ling Liu, Hong-Mei Sun, Qi Shen, Yong Zhang
A novel family of ionic iron(ii) complexes of the general formula [HL][Fe(PR'3)X3] (HL = 1,3-bis(2,6-diisopropylphenyl)imidazolium cation, HIPr, R' = Ph, X = Cl, 2; HL = HIPr, R' = Cy, X = Cl, 3; HL = HIPr, R' = Ph, X = Br, 4; HL = HIPr, R' = Cy, X = Br, 5; HL = 1,3-bis(2,4,6-trimethylphenyl)imidazolium cation, HIMes, R' = Cy, X = Br, 6) was easily prepared via a stepwise approach in 88%-92% yields. In addition, an ionic iron(ii) complex, [HIPr][Fe(C4H8O)Cl3] (1), has been isolated from the reaction of FeCl2(THF)1...
October 21, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27757594/iron-bioavailability-from-supplemented-formula-milk-effect-of-lactoferrin-addition
#16
Sonia Fernández-Menéndez, María L Fernández-Sánchez, Héctor González-Iglesias, Belén Fernández-Colomer, José López-Sastre, Alfredo Sanz-Medel
PURPOSE: In this work, the absorption and/or bioavailability of iron from two chemical species, (57)Fe-Lf (apo-lactoferrin) complex and (57)FeSO4 at low and high dose, and in Lf excess were investigated in lactating wistar rats. METHODS: The methodology used is based on the use of stable isotopes in combination with the approach "isotope pattern deconvolution" and ICP-MS for detection. This approach provides quantitative information about exogenous ((57)Fe) and endogenous iron ((nat)Fe) distribution in fluids and tissues in the iron-supplemented rat groups...
October 18, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27737009/heart-rate-variability-for-early-detection-of-cardiac-iron-deposition-in-patients-with-transfusion-dependent-thalassemia
#17
Suchaya Silvilairat, Pimlak Charoenkwan, Suwit Saekho, Adisak Tantiworawit, Arintaya Phrommintikul, Somdet Srichairatanakool, Nipon Chattipakorn
BACKGROUND: Iron overload cardiomyopathy remains the major cause of death in patients with transfusion-dependent thalassemia. Cardiac T2* magnetic resonance imaging is costly yet effective in detecting cardiac iron accumulation in the heart. Heart rate variability (HRV) has been used to evaluate cardiac autonomic function and is depressed in cases of thalassemia. We evaluated whether HRV could be used as an indicator for early identification of cardiac iron deposition. METHODS: One hundred and one patients with transfusion-dependent thalassemia were enrolled in this study...
2016: PloS One
https://www.readbyqxmd.com/read/27731989/real-time-studies-of-iron-oxalate-mediated-oxidation-of-glycolaldehyde-as-a-model-for-photochemical-aging-of-aqueous-tropospheric-aerosols
#18
Daniel A Thomas, Matthew M Coggon, Hanna Lignell, Katherine Ann Schilling, Xuan Zhang, Rebecca H Schwantes, Richard C Flagan, John H Seinfeld, Jesse Lee Beauchamp
The complexation of iron (III) with oxalic acid in aqueous solution yields a strongly absorbing chromophore that undergoes efficient photodissociation to give iron (II) and the carbon dioxide anion radical. Importantly, iron (III) oxalate complexes absorb near-UV radiation (λ > 350 nm), providing a potentially powerful source of oxidants in aqueous tropospheric chemistry. Although this photochemical system has been studied extensively, the mechanistic details associated with its role in the oxidation of dissolved organic matter within aqueous aerosol remain largely unknown...
October 12, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27730505/iron-impregnated-biochars-as-effective-phosphate-sorption-materials
#19
Barbora Micháleková-Richveisová, Vladimír Frišták, Martin Pipíška, Libor Ďuriška, Eduardo Moreno-Jimenez, Gerhard Soja
A new post-treatment method was applied for improving the sorption efficiency of biochar-based sorbents for anionic forms of phosphorus. The Fe-impregnation through direct hydrolysis of Fe(NO3)3 was used to produce impregnated corn cob- (IBC A), garden wood waste- (IBC B), and wood chip-derived biochars (IBC C). The qualitative and quantitative effects of impregnation process on biochars were confirmed by SEM-EDX, FTIR, and ICP-MS. The analyses revealed increased concentrations of N and thus potential NO3(-) participation in the phosphate sorption process...
October 11, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27730342/myocardial-and-liver-iron-overload-assessed-using-t2-magnetic-resonance-imaging-with-an-excel-spreadsheet-for-post-processing-in-tunisian-thalassemia-major-patients
#20
Monia Ouederni, Monia Ben Khaled, Fethi Mellouli, Elhem Ben Fraj, Nawel Dhouib, Ismehen Ben Yakoub, Selem Abbes, Nejla Mnif, Mohamed Bejaoui
Thalassemia is a common genetic disorder in Tunisia. Early iron concentration assessment is a crucial and challenging issue. Most of annual deaths due to iron overload occurred in underdeveloped regions of the world. Limited access to liver and heart MRI monitoring might partially explain these poor prognostic results. Standard software programs are not available in Tunisia. This study is the first to evaluate iron overload in heart and liver using the MRI T2* with excel spreadsheet for post processing. Association of this MRI tool results to serum ferritin level, and echocardiography was also investigated...
October 12, 2016: Annals of Hematology
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