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MS and iron

Mingyue Bai, Wenwei Han, Xia Zhao, Qingchi Wang, Yanyun Gao, Shiming Deng
Sea snakes have wide application prospects in medicine, health food and other fields. Several novel polysaccharides were successfully obtained from the skin and the meat of a sea snake ( Lapemis curtus ). The structures of polysaccharides LSP3 and LMP3, which were extracted and purified from Lapemis curtus , were determined to be new and highly heterogenic glycosaminoglycans (GAGs) by means of FT-IR, ESI-MS/MS and NMR. LSP3 is a hybrid dermatan sulfate (DS) and composed of 48% 4-sulfated disaccharides (Di4S), 42% 6-sulfated disaccharides (Di6S) and 5% disulfated disaccharides (Di2,6S), while LMP3 is a hybrid chondroitin sulfate (CS) and composed of 70% Di4S, 20% Di6S, and 8% Di2,6S...
May 18, 2018: Marine Drugs
Ellen M H Schmitz, Niels M Leijten, Joost L J van Dongen, Maarten A C Broeren, Lech G Milroy, Luc Brunsveld, Volkher Scharnhorst, Daan van de Kerkhof
BACKGROUND: Targeted quantification of protein biomarkers with liquid chromatography-tandem mass spectrometry (LC-MS/MS) has great potential, but is still in its infancy. Therefore, we elucidated the influence of charge state distribution and matrix effects on accurate quantification, illustrated by the peptide hormone hepcidin. METHODS: An LC-MS/MS assay for hepcidin, developed based on existing literature, was improved by using 5 mM ammonium formate buffer as mobile phase A and as an elution solution for solid phase extraction (SPE) to optimize the charge state distribution...
May 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Hangzhen Lan, Leo D Salmi, Tuukka Rönkkö, Jevgeni Parshintsev, Matti Jussila, Kari Hartonen, Marianna Kemell, Marja-Liisa Riekkola
New chemical vapor reaction (CVR) and atomic layer deposition (ALD)-conversion methods were utilized for preparation of metal organic frameworks (MOFs) coatings of solid phase microextraction (SPME) Arrow for the first time. With simple, easy and convenient one-step reaction or conversion, four MOF coatings were made by suspend ALD iron oxide (Fe2 O3 ) film or aluminum oxide (Al2 O3 ) film above terephthalic acid (H2 BDC) or trimesic acid (H3 BTC) vapor. UIO-66 coating was made by zirconium (Zr)-BDC film in acetic acid vapor...
September 18, 2018: Analytica Chimica Acta
Ali Pirasteh, Qing Yuan, Diego Hernando, Scott B Reeder, Ivan Pedrosa, Takeshi Yokoo
PURPOSE: To assess the reproducibility of biexponential R2 -relaxometry MRI for estimation of liver iron concentration (LIC) between proprietary and nonproprietary analysis methods. METHODS: This single-center retrospective study, approved by investigational review board and compliant with the Health Insurance Portability and Accountability Act, included 40 liver MRI exams in 38 subjects with suspected or known iron overload. From spin-echo images of the liver, acquired at 5 different echo times (TE = 6-18 ms), biexponential R2 maps were calculated using 1 proprietary (FerriScan, Resonance Health Ltd...
May 16, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Jieting Ma, Yunlu Chen, Jianxin Nie, Luming Ma, Yuanxing Huang, Liang Li, Yan Liu, Zhigang Guo
A pilot scale reactor with an effective volume of 2.93 m3 was built in-situ and run in both batch and continuous modes to investigate the removal for organic pollutants in bio-treated dyeing and finishing wastewater by heterogeneous catalytic ozonation under neutral pH with waste iron shavings as a catalyst. Experimental results showed that both running modes were able to reduce the chemical oxygen demand (COD) from 132-148 mg/L to a level below the discharge criteria (<80 mg/L) within 15-30 mins under several conditions...
May 15, 2018: Scientific Reports
N Earnest, S Chakram, Y Lu, N Irons, R K Naik, N Leung, L Ocola, D A Czaplewski, B Baker, Jay Lawrence, Jens Koch, D I Schuster
We realize a Λ system in a superconducting circuit, with metastable states exhibiting lifetimes up to 8 ms. We exponentially suppress the tunneling matrix elements involved in spontaneous energy relaxation by creating a "heavy" fluxonium, realized by adding a capacitive shunt to the original circuit design. The device allows for both cavity-assisted and direct fluorescent readouts, as well as state preparation schemes akin to optical pumping. Since direct transitions between the metastable states are strongly suppressed, we utilize Raman transitions for coherent manipulation of the states...
April 13, 2018: Physical Review Letters
Chen Wen, Xiaoyi Xu, Yunshuang Fan, Changfa Xiao, Cong Ma
Coagulation-sedimentation combined with sponge iron/ozone (CS-SFe/O3 ) technology was applied to pretreat water-based seed coating wastewater (WSCW) from pesticide manufacturing. Coagulation with polyferric sulfate at a dosage of 1.5 g L-1 and a pH of 8.0 was effective, with color and chemical oxygen demand (COD) removal rates of 96.8 and 83.4%, respectively. SFe/O3 treatment further reduced the organic content in the effluents, especially concerning the degradation of aromatic pollutants, as demonstrated via ultraviolet-visible spectrophotometry (UV-vis), excitation-emission matrix (EEM) fluorescence spectrometry, and gas chromatography-mass spectrometry (GC/MS) analyses...
May 4, 2018: Chemosphere
Stefanie Fingerhut, Michael Sperling, Markus Holling, Thomas Niederstadt, Thomas Allkemper, Alexander Radbruch, Walter Heindel, Werner Paulus, Astrid Jeibmann, Uwe Karst
Recent studies showed gadolinium depositions following serial administrations of gadolinium-based contrast agents (GBCAs) for magnetic resonance imaging examinations in various parts of the brain with the dentate nucleus (DN) being most affected. Even though no clinical correlates of the deposits are known yet, an intensive debate developed if this might be harmful. The aim of the current study was to specify the gadolinium distribution in brain tissue of patients who received serial injections of GBCAs in the low-µm range and to explore any potential pathological tissue changes caused by gadolinium deposits...
May 10, 2018: Acta Neuropathologica
Li Gan, Beibei Li, Mengyu Guo, Xiulan Weng, Ting Wang, Zuliang Chen
In this paper, iron-based nanoparticles (Fe NPs) synthesized by Euphorbia cochinchensis leaf extract were used to remove 2,4-dichlorophenol (2,4-DCP). The possible mechanism for removing the adsorption and heterogeneous Fenton-like oxidation of 2,4-DCP was investigated. Various parameters affecting removal efficiency were tested, and the results showed that more than 83.5% of 2,4-DCP was removed with the addition of 10 mM H2 O2 and the initial concentration of 2,4-DCP of 30 mg/L at pH 6.26 under 303 K...
April 30, 2018: Chemosphere
Marjan Salari, Gholam Reza Rakhshandehroo, Mohammad Reza Nikoo
The main purpose of this experimental study was to optimize Homogeneous Fenton oxidation (HFO) and identification of oxidized by-products from degradation of Ciprofloxacin (CIP) using hybrid AHP-PROMETHEE, Response Surface Methodology (RSM) and High Performance Liquid Chromatography coupled with Mass Spectrometry (HPLC-MS). At the first step, an assessment was made for performances of two catalysts (FeSO4 ·7H2 O and FeCl2 ·4H2 O) based on hybrid AHP-PROMETHEE decision making method. Then, RSM was utilized to examine and optimize the influence of different variables including initial CIP concentration, Fe2+ concentration, [H2 O2 ]/[ Fe2+ ] mole ratio and initial pH as independent variables on CIP removal, COD removal, and sludge to iron (SIR) as the response functions in a reaction time of 25 min...
April 23, 2018: Chemosphere
Tamás Fődi, Gergő Ignácz, Balázs Decsi, Zoltán Béni, György István Túrós, József Kupai, Diána Balogh-Weiser, István Greiner, Péter Huszthy, György Tibor Balogh
A Medium Throughput Screening (MTS) for iron porphyrin catalyst based biomimetic drug metabolite synthesis is developed. The microplate based method in combination with HPLC-MS analysis was shown to be a useful tool for process development and parameter optimization in the production of targeted metabolites and/or oxidation products of forty-three different drug substances. In case of biomimetic oxidation of amiodarone, quantity and purity of the isolated products enabled detailed HRMS and NMR spectroscopic studies...
May 8, 2018: Chemistry: a European Journal
Tongxiang Song, Huijie Liu, Tengteng Lv, Xuelin Zhao, Yina Shao, Qingxi Han, Chenghua Li, Weiwei Zhang
Under low iron bioavailability environment, many bacteria acquire iron for growth and survival through siderophore-mediated iron acquisition systems. However, until now, little research on the growth, siderophore production and siderophore receptors of Vibrio splendidus Vs under iron limited conditions has been reported. In our present study, V. splendidus Vs could survive in media supplemented with 160 µM 2,2'-dipyridyl (DIP), but 74.5% of the growth was suppressed at 48 h, while the siderophore production of V...
May 3, 2018: Journal of Invertebrate Pathology
Sharmistha Mohapatra, Mohammed Asfer, Mohammed Anwar, Shakeeb Ahmed, Farhan J Ahmad, Anees A Siddiqui
Carboxymethyl Assam Bora rice starch coated superparamagnetic iron oxide nanoparticles (CM-ABRS SPIONs) were chemically synthesized by co-precipitation method and particle size reduction was controlled by high energy homogenization process. Effects of various process variables (polymer concentration, homogenization speed and cycles) were optimized on the basis of average particle size (Z-average) and polydispersity index (PDI) of CM-ABRS SPIONs. The optimized CM-ABRS SPIONs were characterized for their particle size, surface morphology, electrokinetic potential, chemical interactions, crystallinity, magnetic properties, and targeting potential in presence of external magnetic field...
April 30, 2018: International Journal of Biological Macromolecules
Jie Cai, Tongxiang Ren, Yuhui Zhang, Zhilin Wang, Lingyan Gou, Zhengwu Huang, Jun Wang, Jianhua Piao, Xiaoguang Yang, Lichen Yang
Background: Iron is a kind of essential trace mineral in the human body, while the studies on its physiological requirement are very limited recently, especially in China. And most studies were performed with the radioisotope tracer technique, which was harmful to health. This study aimed to first get the value of iron physiological requirements in Chinese adults assessed by the stable isotope labeling technique. Methods: Forty-four eligible young Chinese healthy adults were randomly recruited from the Bethune Military Medical College (Shijiazhuang, Hebei, China) between January 2010 and March 2011, and 19 subjects were included in the final data analysis...
2018: Nutrition & Metabolism
Cecilie Hurup Munkboel, Lise Rudbæk Christensen, Julie Islin, Silvia Bonomo, Lars Olsen, Flemming Steen Jørgensen, Bjarne Styrishave
The potential endocrine disrupting effects of the commonly prescribed anti-epileptic drug lamotrigine (LAM) was investigated using the H295R steroidogenic in vitro assay and computational chemistry methods. The H295R cells were exposed to different concentrations of LAM and a multi-steroid LC-MS/MS method was applied to quantify the amount of secreted steroid hormones. LAM affected several steroid hormones in the steroidogenesis at therapeutic concentrations. All progestagens as well as 11-deoxycorticosterone and corticosterone increased 100-200% with increasing concentrations of LAM suggesting a selective inhibitory effect of LAM on CYP17A1, in particular on the lyase reaction...
April 26, 2018: Biology of Reproduction
Mumbfu Ernestine Mimba, Takeshi Ohba, Salomon César Nguemhe Fils, Melvin Tamnta Nforba, Nozomi Numanami, Tasin Godlove Bafon, Festus Tongwa Aka, Cheo Emmanuel Suh
The distribution of trace metals in active stream sediments from the mineralized Lom Basin has been evaluated. Fifty-five bottom sediments were collected and the mineralogical composition of six pulverized samples determined by XRD. The fine fraction (< 150 µm) was subjected to total digestion (HClO4  + HF + HCl) and analyzed for trace metals using a combination of ICP-MS and AAS analytical methods. Results show that the mineralogy of stream sediments is dominated by quartz (39-86%), phyllosilicates (0-45%) and feldspars (0-27%)...
May 2, 2018: Geochemical Transactions
Chun Zeng, Silin Du, Yongliang Han, Jialiang Fu, Qi Luo, Yayun Xiang, Xiaoya Chen, Tianyou Luo, Yongmei Li, Yineng Zheng
OBJECTIVE: This study aimed to investigate iron deposition and thickness and signal changes in optic radiation (OR) by enhanced T2 * -weighted angiography imaging (ESWAN) in patients with relapsing-remitting multiple sclerosis (RRMS) with unilateral and bilateral lesions or no lesions. METHODS: Fifty-one RRMS patients (42 patients with a disease duration [DD] ≥ 2 years [group Mor], nine patients with a DD < 2 years [group Les]) and 51 healthy controls (group Con) underwent conventional magnetic resonance imaging (MRI) and ESWAN at 3...
April 30, 2018: European Radiology
Dolev Rimmerman, Denis Leshchev, Darren J Hsu, Jiyun Hong, Baxter Abraham, Robert W Henning, Irina Kosheleva, Lin X Chen
Direct tracking of protein structural dynamics during folding-unfolding processes is important for understanding roles of hierarchic structural factors in the formation of functional proteins. Using cytochrome c as a platform, we investigated its structural dynamics during folding processes triggered by local environmental changes (i.e., pH, or heme iron center oxidation/spin/ligation states) with time-resolved x-ray solution scattering measurements. Starting from partially unfolded cyt c, a sudden pH drop initiated by light excitation of a photoacid caused a structural contraction in microseconds, followed by active site restructuring and unfolding in milliseconds...
April 30, 2018: Journal of Physical Chemistry. B
Amir Mirzaei, Zhi Chen, Fariborz Haghighat, Laleh Yerushalmi
Herein, a petal-like photocatalyst, Fe3 O4 -ZnO@g-C3 N4 (FZG) with different g-C3 N4 to ZnO ratios was synthesized with hierarchical structure. The FZG1 photocatalyst, having the weight ratio of 1:1 for the initial urea and Fe3 O4 -ZnO (Fe-ZnO), presented the highest sulfamethoxazole (SMX) degradation rate of 0.0351 (min-1 ), which was 2.6 times higher than that of pristine ZnO. Besides the facile separation, the performance of photocatalyst was improved due to the function of iron oxide as an electron acceptor that reduced the electron/hole recombination rate...
April 21, 2018: Chemosphere
Xiang Li, Minghua Zhou, Yuwei Pan
2,4-dichlorophenoxyacetic acid (2,4-D) is one of the most applicable herbicides in the world, its residue in aquatic environment threatens the human health and ecosystems. In this study, for the first time, inexpensive Fe-C after pre-magnetization (Pre-Fe-C) was used as the heterogeneous catalyst to activate persulfate (PS) for 2,4-D degradation, proving that Pre-Fe-C could significantly improve the degradation and dechlorination. The results indicated the stability and reusability of Pre-Fe-C were much better than pre-magnetization Fe0 (Pre-Fe0 ), while the leaching iron ion was lower, indicating that using Pre-Fe-C not only reduced the post-treatment cost, but also enhanced the removal and dechlorination efficiency of 2,4-D...
April 21, 2018: Journal of Hazardous Materials
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