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digitalis intoxication

L Cornara, A Smeriglio, J Frigerio, M Labra, E Di Gristina, M Denaro, E Mora, D Trombetta
Today, in many European countries, people are looking for wild edible plants to experience new tastes and flavors, by following the new trend of being green and environmentally friendly. Young borage and spinach leaves can be easily confused by inexpert pickers with those of other plants, including poisonous ones, such as Mandragora autumnalis Bertol. (mandrake) or Digitalis purpurea L. (foxglove), common in southern and northern Italy respectively. In the last twenty years, several cases of intoxication by accidental ingestion of mandrake and foxglove have been reported...
May 10, 2018: Food and Chemical Toxicology
W Grimm, A Grimm, K Grimm, E Efimova
A number of rare cardiac diseases can be recognized by electrocardiogram (ECG). This article illustrates the clinical importance of ECG as a key diagnostic tool to detect Wolff-Parkinson-White syndrome and channelopathies, which are frequently diagnosed late after one or more affected family members have become victims of sudden cardiac death. These channelopathies include long QT syndrome, short QT syndrome, Brugada syndrome, and catecholaminergic polymorphic ventricular tachycardia. In addition, typical ECG findings are frequently present in patients with idiopathic ventricular tachycardia, arrhythmogenic right ventricular dysplasia, digitalis intoxication, hyperkalemia, acute cor pulmonale due to pulmonary embolism, as well as severe left ventricular hypertrophy as in hypertrophic cardiomyopathy...
April 4, 2018: Der Internist
Emma M García-Iranzo, Francisco J Rodríguez-Lucena, Carmen Matoses-Chirivella, Ana García-Monsalve, Ana Cristina Murcia-López, Andrés Navarro-Ruiz
INTRODUCTION: The serum digoxin concentration (SDC) should be between 0.8 and 2 ng/ml. The objective is to assess the pharmacokinetic monitoring of SDC performed from primary healthcare (PH) in patients with chronic treatment. METHODS: Cross-sectional retrospective study of patients with chronic treatment with digoxin belonging to the department of a General University Hospital.Data were analized: age, sex, diagnosis, number of serum digoxin concentration determinations, date and origin of the request for monitoring, analytical result and pharmacokinetic assessment are collected...
July 1, 2017: Farmacia Hospitalaria
Alfonsina Marino, Lorenzo Giordano, Francesco Ardu
The filter has been approved by the Food and Drug Administration for the removal of beta-2 microglobulin in patient undergoing hemodialysis. We used the filter (the patient agrees) off label, in the course of digitalis intoxication and we have shown that the filter is capable of removing the drug effectively.
April 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Monique Bernard, Jean-Michel Maixent, Alain Gerbi, Carole Lan, Patrick Jean Cozzone, Gérard Pieroni, Martine Armand, Thierry Charles Coste
Docosahexaenoic acid (DHA) might prevent heart failure or optimise drug treatments by improving cardiac contraction. We investigated whether DHA-enriched avian glycerophospholipids (GPL-DHA) exert cardioprotection in ouabain-treated rats after 4 weeks of dietary supplementation with 10, 35 or 60 mg DHA per kg body weight versus none (DHA10, DHA35, DHA60 and control groups, respectively). The contractile responsiveness to different doses of ouabain (10(-7) to 10(-4) M), ouabain intoxication (at 3 × 10(-4) M), and relative variations in cardiac energy metabolism were determined using (31)P NMR in isolated perfused rat hearts...
February 2016: Food & Function
Felipe C Souza, Emiliana B Marques, Rogério B M Scaramello, B V Christianne
Digoxin is used for heart failure associated to systolic dysfunction and high ventricular rate. It has a narrow therapeutic range and intoxication may occur due to drug interactions or comorbidities. The aim of this work was to study digoxin use in a public health unit delineating the profile of patients susceptible to digitalis intoxication. Medical records belonging to patients admitted to the cardiomyopathy ward of the health unit (2009-2010) and in use of digoxin were analyzed. Among 647 patients admitted, 185 individuals using digoxin and possessed records available...
April 2015: Anais da Academia Brasileira de Ciências
Diletta Sabatini, Giovanni Truscelli, Antonio Ciccaglioni, Carlo Gaudio, Maria Caterina Grassi
Acute digoxin intoxication is a life-threating condition associated with severe cardiotoxicity. Female gender, age, low lean body mass, hypertension, and renal insufficiency may worsen the prognosis. Arrhythmias caused by digitalis glycosides are characterized by an increased automaticity coupled with concomitant conduction delay. Bidirectional tachycardia is pathognomonic of digoxin intoxication, but it is rarely observed. An 83-year-old woman was admitted to the Emergency Department after self-administration of 5 mg of digoxin i...
2014: Case Reports in Psychiatry
Stefano Maffè, Paola Paffoni, Maria Laura Colombo, Franca Davanzo, Pierfranco Dellavesa, Lorenzo Cucchi, Franco Zenone, Anna Maria Paino, Nicolò Franchetti Pardo, Luca Bergamasco, Fabiana Signorotti, Umberto Parravicini
Accidental or deliberate ingestion of poisonous herbs has become an increasingly common phenomenon over the last years. From existing literature data and case reports from emergency room visits or poison control centers, an overview is presented of the potential cardiotoxic manifestations following intoxication by wild herbal plants of the territory. The effects of the consumption of cardiac glycoside-containing plants (e.g., digitalis) are discussed along with tachyarrhythmias induced by Aconitum napellus L...
June 2013: Giornale Italiano di Cardiologia
Éric Pautas, Clara Lopez, Adeline Gouronnec, Sophie Gravelaine, Isabelle Peyron, Frédéric Lapostolle
The indications for digoxin are currently limited to rare cases of heart failure and/or atrial fibrillation. Its use should be even more rare in geriatrics its pharmacological characteristics, associated with age-related changes and comorbidities, particularly increase the risk of digoxin poisoning in the elderly. However, at least a third of aged patients suffering from heart failure and/or atrial fibrillation is treated by digitalis. Digoxin intoxication can provoke gastrointestinal troubles, neurological disturbances and, above all, cardiac conduction impairment and dysrythmias, which explain its severity and high mortality rate...
December 2012: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
Luigi M Castello, Sophie Negro, Francesca Santi, Isabella Zanotti, Matteo Vidali, Marco Bagnati, Giorgio Bellomo, Gian Carlo Avanzi
INTRODUCTION: Two Italian adults arrived at the Emergency Department referring diarrhea, nausea and vomiting for 4 days; weakness, fatigue and visual hallucinations were also complained of. Patients reported the ingestion of some leaves of a plant, which they supposed to be "donkey ears", a week before. Physical examination showed hypotension and bradycardia and ECG examination disclosed sinus rhythm and repolarization abnormalities (scooping of the ST-T complex) in both patients and a 2:1 AV block in the man...
2012: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
Joachim Alexandre, Anthony Foucault, Guillaume Coutance, Patrice Scanu, Paul Milliez
No abstract text is available yet for this article.
February 28, 2012: Circulation
Shu-Hua Ma, Jun-Hong Gao, Yu-Min Wang, Meng Zhang, Yan-Yan Ma, Jian-Jiang Hu, Wei-Xing Fu, Hai-Feng Cui, Xiao-Chun Yu
Digitalis glycosides, a group of cardiotonic agents for heart failure, have been used for a long time, but may often trigger arrhythmias as a result of digitalis intoxication. It is of great significance in finding a method to reduce their toxicity and improve clinical curative effects simultaneously in the application of digitalis glycosides. It has been well documented that acupuncture has good therapeutic effects in improving cardiac function and inhibiting arrhythmia induced by myocardial ischemia. Acupuncture combined with chemotherapeutics can reduce the adverse effects of chemotherapeutics...
June 2011: Zhen Ci Yan Jiu, Acupuncture Research
A Schott
No abstract text is available yet for this article.
November 1964: Postgraduate Medical Journal
Kevin T Fitzgerald
Lilies are commonly kept flowering ornamental plants that are used in holiday celebrations, weddings, and funerals, and in various floral arrangements. Lilies of genera Lilium and Hemerocallis (day lilies) have been shown to cause nephrotoxicity in cats. Confusion arises because so many different plants are called lilies. Members of the genus Convallaria (lily of the valley), while sparing on the kidneys, elicit toxic effects because they possess potent cardiac glycosides similar to digitalis. Even more confusing as to which lilies are toxic is the fact that many hybrids exist...
November 2010: Topics in Companion Animal Medicine
No abstract text is available yet for this article.
April 1946: Journal of the Arkansas Medical Society
Salvador Pita-Fernández, Mónica Lombardía-Cortiña, Domingo Orozco-Veltran, Vicente Gil-Guillén
This study aimed to determine the clinical characteristics of elderly patients diagnosed with digitalis intoxication, on the Emergency Department, University Hospital Complex, A Coruña, Spain. During the study period (January-September 2008) cases were included in which digitalis intoxication was confirmed by plasma digoxin levels. We collected data on age, gender, base-line diseases, therapeutic indications for digoxin, functional classification, ejection fraction, plasma digoxin levels, creatinine clearance, ions, gasometry, electrocardiogram, concomitant medication, symptomatology and treatment...
September 2011: Archives of Gerontology and Geriatrics
M Urtizberea, M Rochdi, F J Baud, J M Scherrmann
Toxicity of cardiac glycosides involves the inhibition of the Na(+)-K(+) ATPase pump. As a consequence, extracellular K(+) concentration rises and intracellular K(+) concentration strongly decreases. Red blood cell (RBC) K(+) is a practical marker of ATPase inhibition. In a group of 15 patients intoxicated by digitoxin and lanatoside C, correlations between the calculated digitoxin ingested dose or plasma digitoxin levels and the kinetics of plasma K(+) and RBC K(+) have been assessed using kinetic-effect modelling...
1990: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Alexander Kunz, Hans Marty, Felix Nohl, Wolfgang Schmitt, Uwe Schiemann
BACKGROUND: Intoxications are frequent and relevant medical problems in emergency units. CASE REPORT: We report of a mixed intoxication with monkshood and large yellow foxglove. A 39-year-old mentally ill drug addict, intent on committing suicide, swallowed an undefined amount of chaffed monkshood and large yellow foxglove. The typical symptoms of an intoxication occurred, including high-grade ventricular and supraventricular tachyarrhythmias, colic abdominal pain, and peripheral paralysis...
August 2010: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
H A Pickard
Two common clinical problems are discussed, one diagnostic and one therapeutic. Chest pain, because of the possibility of cardiac origin, makes it an urgent diagnostic problem. Ischemic chest pain is considered from a diagnostic standpoint. Common causes of chest pain other than those of cardiac origin are considered. The objectives and basis of therapy for angina are briefly reviewed. Digitalis is discussed from the standpoint of its use and abuse. Digitalis intoxication is frequently overlooked, and it may be the cause of deterioration of the patient's cardiac status, rather than progression of the basic cardiac problem...
March 1974: Canadian Family Physician Médecin de Famille Canadien
No abstract text is available yet for this article.
January 4, 1947: Philadelphia Medicine
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