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digitalis intoxication

Monique Bernard, Jean-Michel Maixent, Alain Gerbi, Carole Lan, Patrick Jean Cozzone, Gérard Pieroni, Martine Armand, Thierry Charles Coste
Docosahexaenoic acid (DHA) might prevent heart failure or optimise drug treatments by improving cardiac contraction. We investigated whether DHA-enriched avian glycerophospholipids (GPL-DHA) exert cardioprotection in ouabain-treated rats after 4 weeks of dietary supplementation with 10, 35 or 60 mg DHA per kg body weight versus none (DHA10, DHA35, DHA60 and control groups, respectively). The contractile responsiveness to different doses of ouabain (10(-7) to 10(-4) M), ouabain intoxication (at 3 × 10(-4) M), and relative variations in cardiac energy metabolism were determined using (31)P NMR in isolated perfused rat hearts...
February 2016: Food & Function
Felipe C Souza, Emiliana B Marques, Rogério B M Scaramello, B V Christianne
Digoxin is used for heart failure associated to systolic dysfunction and high ventricular rate. It has a narrow therapeutic range and intoxication may occur due to drug interactions or comorbidities. The aim of this work was to study digoxin use in a public health unit delineating the profile of patients susceptible to digitalis intoxication. Medical records belonging to patients admitted to the cardiomyopathy ward of the health unit (2009-2010) and in use of digoxin were analyzed. Among 647 patients admitted, 185 individuals using digoxin and possessed records available...
April 2015: Anais da Academia Brasileira de Ciências
Diletta Sabatini, Giovanni Truscelli, Antonio Ciccaglioni, Carlo Gaudio, Maria Caterina Grassi
Acute digoxin intoxication is a life-threating condition associated with severe cardiotoxicity. Female gender, age, low lean body mass, hypertension, and renal insufficiency may worsen the prognosis. Arrhythmias caused by digitalis glycosides are characterized by an increased automaticity coupled with concomitant conduction delay. Bidirectional tachycardia is pathognomonic of digoxin intoxication, but it is rarely observed. An 83-year-old woman was admitted to the Emergency Department after self-administration of 5 mg of digoxin i...
2014: Case Reports in Psychiatry
Stefano Maffè, Paola Paffoni, Maria Laura Colombo, Franca Davanzo, Pierfranco Dellavesa, Lorenzo Cucchi, Franco Zenone, Anna Maria Paino, Nicolò Franchetti Pardo, Luca Bergamasco, Fabiana Signorotti, Umberto Parravicini
Accidental or deliberate ingestion of poisonous herbs has become an increasingly common phenomenon over the last years. From existing literature data and case reports from emergency room visits or poison control centers, an overview is presented of the potential cardiotoxic manifestations following intoxication by wild herbal plants of the territory. The effects of the consumption of cardiac glycoside-containing plants (e.g., digitalis) are discussed along with tachyarrhythmias induced by Aconitum napellus L...
June 2013: Giornale Italiano di Cardiologia
Éric Pautas, Clara Lopez, Adeline Gouronnec, Sophie Gravelaine, Isabelle Peyron, Frédéric Lapostolle
The indications for digoxin are currently limited to rare cases of heart failure and/or atrial fibrillation. Its use should be even more rare in geriatrics its pharmacological characteristics, associated with age-related changes and comorbidities, particularly increase the risk of digoxin poisoning in the elderly. However, at least a third of aged patients suffering from heart failure and/or atrial fibrillation is treated by digitalis. Digoxin intoxication can provoke gastrointestinal troubles, neurological disturbances and, above all, cardiac conduction impairment and dysrythmias, which explain its severity and high mortality rate...
December 2012: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
Luigi M Castello, Sophie Negro, Francesca Santi, Isabella Zanotti, Matteo Vidali, Marco Bagnati, Giorgio Bellomo, Gian Carlo Avanzi
INTRODUCTION: Two Italian adults arrived at the Emergency Department referring diarrhea, nausea and vomiting for 4 days; weakness, fatigue and visual hallucinations were also complained of. Patients reported the ingestion of some leaves of a plant, which they supposed to be "donkey ears", a week before. Physical examination showed hypotension and bradycardia and ECG examination disclosed sinus rhythm and repolarization abnormalities (scooping of the ST-T complex) in both patients and a 2:1 AV block in the man...
2012: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
Joachim Alexandre, Anthony Foucault, Guillaume Coutance, Patrice Scanu, Paul Milliez
No abstract text is available yet for this article.
February 28, 2012: Circulation
Shu-Hua Ma, Jun-Hong Gao, Yu-Min Wang, Meng Zhang, Yan-Yan Ma, Jian-Jiang Hu, Wei-Xing Fu, Hai-Feng Cui, Xiao-Chun Yu
Digitalis glycosides, a group of cardiotonic agents for heart failure, have been used for a long time, but may often trigger arrhythmias as a result of digitalis intoxication. It is of great significance in finding a method to reduce their toxicity and improve clinical curative effects simultaneously in the application of digitalis glycosides. It has been well documented that acupuncture has good therapeutic effects in improving cardiac function and inhibiting arrhythmia induced by myocardial ischemia. Acupuncture combined with chemotherapeutics can reduce the adverse effects of chemotherapeutics...
June 2011: Zhen Ci Yan Jiu, Acupuncture Research
A Schott
No abstract text is available yet for this article.
November 1964: Postgraduate Medical Journal
Kevin T Fitzgerald
Lilies are commonly kept flowering ornamental plants that are used in holiday celebrations, weddings, and funerals, and in various floral arrangements. Lilies of genera Lilium and Hemerocallis (day lilies) have been shown to cause nephrotoxicity in cats. Confusion arises because so many different plants are called lilies. Members of the genus Convallaria (lily of the valley), while sparing on the kidneys, elicit toxic effects because they possess potent cardiac glycosides similar to digitalis. Even more confusing as to which lilies are toxic is the fact that many hybrids exist...
November 2010: Topics in Companion Animal Medicine
No abstract text is available yet for this article.
April 1946: Journal of the Arkansas Medical Society
Salvador Pita-Fernández, Mónica Lombardía-Cortiña, Domingo Orozco-Veltran, Vicente Gil-Guillén
This study aimed to determine the clinical characteristics of elderly patients diagnosed with digitalis intoxication, on the Emergency Department, University Hospital Complex, A Coruña, Spain. During the study period (January-September 2008) cases were included in which digitalis intoxication was confirmed by plasma digoxin levels. We collected data on age, gender, base-line diseases, therapeutic indications for digoxin, functional classification, ejection fraction, plasma digoxin levels, creatinine clearance, ions, gasometry, electrocardiogram, concomitant medication, symptomatology and treatment...
September 2011: Archives of Gerontology and Geriatrics
M Urtizberea, M Rochdi, F J Baud, J M Scherrmann
Toxicity of cardiac glycosides involves the inhibition of the Na(+)-K(+) ATPase pump. As a consequence, extracellular K(+) concentration rises and intracellular K(+) concentration strongly decreases. Red blood cell (RBC) K(+) is a practical marker of ATPase inhibition. In a group of 15 patients intoxicated by digitoxin and lanatoside C, correlations between the calculated digitoxin ingested dose or plasma digitoxin levels and the kinetics of plasma K(+) and RBC K(+) have been assessed using kinetic-effect modelling...
1990: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Alexander Kunz, Hans Marty, Felix Nohl, Wolfgang Schmitt, Uwe Schiemann
BACKGROUND: Intoxications are frequent and relevant medical problems in emergency units. CASE REPORT: We report of a mixed intoxication with monkshood and large yellow foxglove. A 39-year-old mentally ill drug addict, intent on committing suicide, swallowed an undefined amount of chaffed monkshood and large yellow foxglove. The typical symptoms of an intoxication occurred, including high-grade ventricular and supraventricular tachyarrhythmias, colic abdominal pain, and peripheral paralysis...
August 2010: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
H A Pickard
Two common clinical problems are discussed, one diagnostic and one therapeutic. Chest pain, because of the possibility of cardiac origin, makes it an urgent diagnostic problem. Ischemic chest pain is considered from a diagnostic standpoint. Common causes of chest pain other than those of cardiac origin are considered. The objectives and basis of therapy for angina are briefly reviewed. Digitalis is discussed from the standpoint of its use and abuse. Digitalis intoxication is frequently overlooked, and it may be the cause of deterioration of the patient's cardiac status, rather than progression of the basic cardiac problem...
March 1974: Canadian Family Physician Médecin de Famille Canadien
No abstract text is available yet for this article.
January 4, 1947: Philadelphia Medicine
A E Cohn, R A Jamieson
We have shown in a series of 105 cases of pneumonia, 95 of which we have selected as available for statistical study, that digitalis given by mouth has an action on the heart. We have judged this action to be present because changes occurred in the auriculoventricular conduction time and in the form of the T wave of the electrocardiogram, just as they do in the non-febrile heart. This conclusion is strengthened by finding that the pulse rate in fibrillating and fluttering cases fell in the presence of fever, exactly as it does in non-febrile cases...
January 1, 1917: Journal of Experimental Medicine
Stefano Maffè, Lorenzo Cucchi, Franco Zenone, Cristina Bertoncelli, Federico Beldì, Maria Laura Colombo, Massimo Bielli, Anna Maria Paino, Umberto Parravicini, Paola Paffoni, Pierfranco Dellavesa, Antonello Perucca, Nicolò Franchetti Pardo, Fabiana Signorotti, Claudio Didino, Marco Zanetta
Advanced Digitalis intoxication is a rare event, mainly associated with overdose in patients with Digitalis therapy. We report an unusual case of acute 'familiar' digitalis poisoning in three patients who had eaten potato dumplings flavoured with leaves of Borago officinalis L. unconsciously mixed with leaves of Digitalis purpurea L. A complicated clinical course with marked bradyarrhythmias was presented, with good evolution thanks to the use of digoxin-specific antibody Fab fragments. The theme of the domestic use of plants with medicinal effects has been treated and discussed...
September 2009: Journal of Cardiovascular Medicine
Jacqueline Kupper, Cornelia Reichert
Ingestions of plants rarely lead to life-threatening intoxications. Highly toxic plants, which can cause death, are monkshood (Aconitum sp.), yew (Taxus sp.) and autumn crocus (Colchicum autumnale). Lethal ingestions of monkshood and yew are usually suicides, intoxications with autumn crocus are mostly accidental ingestions of the leaves mistaken for wild garlic (Allium ursinum). Severe intoxications can occur with plants of the nightshade family like deadly nightshade (Atropa belladonna), angel's trumpet (Datura suaveolens) or jimsonweed (Datura stramonium)...
May 2009: Therapeutische Umschau. Revue Thérapeutique
Eva Houlberg, Thalia M Estrup Blicher
In the case of severe digoxin intoxication, an antidote digoxin immune Fab (Digibind) is available. Digibind binds and inactivates digoxin. Measuring se-digoxin after administering Digibind (by standard measuring methods) is misleading as Digibind interferes with digitalis immunoassay measurements. The effect of Digibind must be estimated on the basis of the disappearance of the patient's symptoms and cardiac abnormalities. A case involving Fab therapy of a digoxin-overdosed patient is reported.
October 13, 2008: Ugeskrift for Laeger
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