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https://www.readbyqxmd.com/read/29016715/matrix-metalloproteinase-2-knockout-prevents-angiotensin-ii-induced-vascular-injury
#1
Tlili Barhoumi, Julio C Fraulob-Aquino, Muhammad Oneeb Rehman Mian, Sofiane Ouerd, Noureddine Idris-Khodja, Ku-Geng Huo, Asia Rehman, Antoine Caillon, Bianca Dancose-Giambattisto, Talin Ebrahimian, Stéphanie Lehoux, Pierre Paradis, Ernesto L Schiffrin
Aims: Matrix metalloproteinases (MMPs) have been implicated in the development of hypertension in animal models and humans. Mmp2 deletion did not change Ang II-induced blood pressure (BP) rise. However, whether Mmp2 knockout affects angiotensin (Ang) II-induced vascular injury has not been tested. We sought to determine whether Mmp2 knockout will prevent Ang II-induced vascular injury. Methods and results: A fourteen-day Ang II infusion (1000 ng/kg/min, SC) increased systolic BP, decreased vasodilatory responses to acetylcholine, induced mesenteric artery (MA) hypertrophic remodelling, and enhanced MA stiffness in wild-type (WT) mice...
July 20, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28856972/elastography-methods-for-the-non-invasive-assessment-of-portal-hypertension
#2
Davide Roccarina, Matteo Rosselli, Joan Genesca, Emmanuel A Tsochatzis
The gold standard to assess the presence and severity of portal hypertension remains the hepatic vein pressure gradient, however the recent development of non-invasive assessment using elastography techniques offers valuable alternatives. In this review, we discuss the diagnostic accuracy and utility of such techniques in patients with portal hypertension due to cirrhosis. Areas covered: A literature search focused on liver and spleen stiffness measurement with different elastographic techniques for the assessment of the presence and severity of portal hypertension and oesophageal varices in people with chronic liver disease...
September 12, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28853196/a-new-screening-strategy-for-varices-by-liver-and-spleen-stiffness-measurement-lssm-in-cirrhotic-patients-a-randomized-trial
#3
Grace Lai-Hung Wong, Raymond Kwok, Aric Josun Hui, Yee-Kit Tse, Kai-Tin Ho, Angeline Oi-Shan Lo, Kelvin Long-Yan Lam, Heyson Chi-Hey Chan, Rashid Abdul Lui, Kenneth Hon-Da Au, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong
BACKGROUND: Variceal bleeding is a common and life-threatening complication in patients with liver cirrhosis. Screening with upper endoscopy is recommended but is uncomfortable to patients. Non-invasive assessment with transient elastography for liver/spleen stiffness measurement (LSM and SSM) is accurate in detecting varices. AIMS: To test the hypothesis that a new screening strategy for varices guided by LSM/SSM results (LSSM-guided) is non-inferior to universal endoscopic screening in detecting clinically significant varices in patients with cirrhosis...
August 29, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28845498/non-invasive-diagnosis-of-portal-hypertension-in-cirrhosis-using-ultrasound-based-elastography
#4
REVIEW
Ivica Grgurevic, Tomislav Bokun, Tonci Bozin, Vladimir Matic, Sara Haberle, Ioan Sporea
Liver stiffness measurement (LSM) by ultrasound-based elastography may be used to non-invasively discriminate between the stages of liver fibrosis, rule out cirrhosis and follow its evolution, including the prediction of the presence of oesophageal varices. The same is possible in order to diagnose clinically significant portal hypertension, referring primarilyto transient elastography and LSM values ≥20-25 kPa. The same approach may be used to reliably rule out the presence ofoesophageal varices (LSM <20 kPa + platelets >150x109/L)...
May 3, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28835776/rapid-liver-and-spleen-stiffness-improvement-in-compensated-advanced-chronic-liver-disease-patients-treated-with-oral-antivirals
#5
Mònica Pons, Begoña Santos, Macarena Simón-Talero, Meritxell Ventura-Cots, Mar Riveiro-Barciela, Rafael Esteban, Salvador Augustin, Joan Genescà
BACKGROUND: We aimed to investigate the early changes in liver and spleen stiffness measurement (LSM, SSM) in hepatitis C virus (HCV) patients with compensated advanced chronic liver disease (cACLD) treated with new antivirals (DAA) to elucidate factors determining the initial change in stiffness and its implications for the long-term follow up of HCV-cured patients. METHODS: A total of 41 patients with cACLD who started DAA therapy underwent LSM and SSM at baseline, week 4, end of treatment (EOT), 24 and 48 weeks of follow up using transient elastography...
August 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28834899/predicting-the-risk-of-postoperative-liver-failure-and-overall-survival-using-liver-and-spleen-stiffness-measurements-in-patients-with-hepatocellular-carcinoma
#6
Dongbo Wu, Enqiang Chen, Tao Liang, Menglan Wang, Bin Chen, Bai Lang, Hong Tang
Postoperative liver failure (PLF) is the primary cause of morbidity and mortality after hepatic resection for hepatocellular carcinoma (HCC). In this study, we evaluated the efficacy of liver stiffness (LS) and spleen stiffness (SS), as measured by transient elastography (TE), for predicting the risk of PLF and overall survival (OS) in these patients.This prospective cohort study included 54 patients diagnosed with HCC who underwent hepatic resection between March 2013 and March 2014. Preoperative measurement of LS and SS using TE was performed on all patients underwent...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28753738/the-modification-of-splenic-stiffness-on-acoustic-radiation-force-impulse-parallels-the-variation-of-portal-pressure-induced-by-transjugular-intrahepatic-portosystemic-shunt
#7
Adriano De Santis, Silvia Nardelli, Chiara Bassanelli, Marinella Lupo, Claudia Iegri, Carmela Anna Di Ciesco, Mariana Forlino, Alessio Farcomeni, Oliviero Riggio
BACKGROUND: Spleen and liver stiffness measured by Acoustic radiation force impulse (ARFI) imaging has been showed to be useful in identifying patients with portal hypertension. AIM: to establish if the modification of portal pressure induced by a TIPS parallels the modification of spleen or liver stiffness measured by ARFI in order to understand if ARFI may be used to monitor the modification of portal pressure in patients with cirrhosis. PATIENTS AND METHODS: 38 patients with severe portal hypertension underwent liver stiffness (LS) and spleen stiffness (SS) before TIPS and one week after TIPS...
July 28, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28705556/supersonic-shear-wave-imaging-of-the-spleen-for-staging-of-liver-fibrosis-in-rats
#8
Xiang-Dong Hu, Hui-Ying Geng, Lei Wang, Hu-Feng Xu, Yuan Su, Si Liang, Lin-Xue Qian
The goal of the work described here was to explore the cause of spleen stiffness (SS) in hepatic fibrogenesis and evaluate the value of SS in liver fibrosis (LF) staging. LF was induced with carbon tetrachloride (CCl4) in rats (n = 40). Supersonic shear wave imaging and contrast-enhanced ultrasound were performed to determine liver stiffness (LS), SS and splenic hemodynamics. SS, LS and free portal pressure exhibited moderate correlations with fibrosis stage (r = 0.744-0.835, p < 0.001). Time-intensity curves of contrast-enhanced ultrasound for the spleen were presented as decreasing peak intensity and slope of decrease, and increasing time to peak...
July 10, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28376114/high-risk-of-misinterpreting-liver-and-spleen-stiffness-using-2d-shear-wave-and-transient-elastography-after-a-moderate-or-high-calorie-meal
#9
Maria Kjærgaard, Maja Thiele, Christian Jansen, Bjørn Stæhr Madsen, Jan Görtzen, Christian Strassburg, Jonel Trebicka, Aleksander Krag
Food intake increases liver stiffness, but it is believed that liver stiffness returns to baseline two hours after a meal. The aim of this study was to investigate the impact of different sized meals on liver stiffness. Liver and spleen stiffness was measured with transient elastography (TE) and real-time 2-dimensional shear wave elastography (2D-SWE). Patients ingested a 625 kcal and a 1250 kcal liquid meal on two consecutive days. We measured liver and spleen elasticity, Controlled attenuation parameter (CAP) and portal flow at baseline and after 20, 40, 60, 120 and 180 minutes...
2017: PloS One
https://www.readbyqxmd.com/read/28335998/point-shear-wave-elastography-to-evaluate-and-monitor-changing-portal-venous-pressure-in-patients-with-decompensated-cirrhosis
#10
Hao Han, Jian Yang, Yu-Zheng Zhuge, Ming Zhang, Min Wu
This study evaluated whether the stiffness of the liver and spleen, measured using the point shear wave elastography (pSWE) technique, correlates with portal venous pressure (PVP) and whether the result extends to estimate the diminishing change in PVP (ΔPVP) in patients with decompensated cirrhosis. We evaluated the data of 67 prospectively enrolled patients who underwent both transjugular intrahepatic portosystemic shunt (TIPS) and pSWE. The stiffness of liver and spleen were evaluated by measuring shear wave velocity (SWV) to determine the statistical correlation with PVP...
June 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28329027/prevalence-and-predictors-for-compensated-advanced-chronic-liver-disease-c-acld-in-patients-with-chronic-hepatitis-delta-virus-hdv-infection
#11
Ingrid Couto, Marilu Victoria, Valdiléa G Veloso, Lorena Rodrigues, Beatriz Grinsztejn, Marcus Lacerda, Flamir Victoria, Hugo Perazzo
OBJECTIVE: The study aimed to evaluate the prevalence and predictor factors for compensated advanced chronic liver disease (c-ACLD) in patients with hepatitis Delta virus (HDV) infection. METHODS: This cross-sectional study included consecutive HDV-infected patients defined by positive anti-HDV. Patients with hepatitis C coinfection, liver transplantation or presence of conditions that limit liver (LSM) or spleen stiffness measurement (SSM) were excluded. Blood tests, abdominal ultrasound, SSM and LSM by transient elastography (FibroScan®) were performed at the same day...
2017: PloS One
https://www.readbyqxmd.com/read/28295587/validation-of-noninvasive-methods-to-predict-the-presence-of-gastroesophageal-varices-in-a-cohort-of-patients-with-compensated-advanced-chronic-liver-disease
#12
Elba Llop, Marta Lopez, Juan de la Revilla, Natalia Fernandez, Maria Trapero, Marta Hernandez, Carlos Fernández-Carrillo, Fernando Pons, Jose Luis Martinez, Jose Luis Calleja
BACKGROUND AND AIM: The aim was to validate noninvasive methods to predict the presence of gastroesophageal varices (GEV) in patients with suspected compensated advanced chronic liver disease. METHODS: We retrospectively reviewed clinical and radiological data collected prospectively between September 2013 and September 2015. We reviewed 442 consecutive patients with suspected compensated advanced chronic liver disease measured by transient elastography (TE) and a gastroscopy...
November 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28260293/-clinical-value-of-acoustic-radiation-force-impulse-technique-to-predict-esophageal-and-gastric-varices-in-patients-with-biliary-atresia
#13
G Y Zhang, Y Tang, N N Niu, H T Wu
Objective: To investigate the clinical value of acoustic radiation force impulse (ARFI)technique in predicting esophageal and gastric varices in patients with biliary atresia after Kasai portoenterostomy. Methods: A total of 42 patients with biliary atresia after Kasai portoenterostomy were collected from September 2015 to May 2016 in Tianjin First Central Hospital.ARFI technique was used to measure the stiffness of liver and spleen, and 28 healthy children as control.According to the result of CT examination , patients with biliary atresia were divided into two groups , twenty-three patients with esophageal and gastric varices(A group) and nineteen patients without esophageal and gastric varices (B group), Comparing the difference of liver and spleen stiffness between the two groups...
February 21, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28223101/non-invasive-evaluation-of-portal-hypertension-using-ultrasound-elastography
#14
REVIEW
Annalisa Berzigotti
Portal hypertension (PH) leads to serious complications, such as bleeding from gastroesophageal varices, ascites and portosystemic encephalopathy in patients with chronic liver disease (CLD). Gold standard methods for assessing PH and its complications include the measurement of hepatic venous pressure gradient and endoscopy; however, these are invasive, expensive and not available at all centres. Therefore, non-invasive alternatives have been the subject of extensive investigation over the last 20years. The present review focuses on the role of ultrasound elastography - a novel group of non-invasive techniques used to measure stiffness in target organs...
February 14, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28177946/transient-elastography-evaluation-of-hepatic-and-spleen-stiffness-in-patients-with-hepatosplenic-schistosomiasis
#15
Zulane S T Veiga, Cristiane A Villela-Nogueira, Flávia F Fernandes, Marta G Cavalcanti, Fátima A Figueiredo, João L Pereira, Gustavo H Pereira, Henrique S Moraes Coelho, José M Peralta, Carlos E Marques, Renata M Perez, Homero S Fogaça
BACKGROUND: Hepatosplenic schistosomiasis (HES) has not been evaluated by transient elastography so far and its correlation with ultrasound variables remains to be defined. AIMS: The aim of this study was to describe the parameters of liver and spleen stiffness in HES assessed by transient elastography in comparison with cirrhotics and controls evaluating its correlation with ultrasonographic data. PATIENTS AND METHODS: HES, hepatitis C virus-cirrhotic, and control patients were included in this sectional study...
June 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28104976/clinical-role-of-non-invasive-assessment-of-portal-hypertension
#16
EDITORIAL
Massimo Bolognesi, Marco Di Pascoli, David Sacerdoti
Measurement of portal pressure is pivotal in the evaluation of patients with liver cirrhosis. The measurement of the hepatic venous pressure gradient represents the reference method by which portal pressure is estimated. However, it is an invasive procedure that requires significant hospital resources, including experienced staff, and is associated with considerable cost. Non-invasive methods that can be reliably used to estimate the presence and the degree of portal hypertension are urgently needed in clinical practice...
January 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28063644/are-transient-and-shear-wave-elastography-useful-tools-in-gaucher-disease
#17
Muriel Webb, Ari Zimran, Tama Dinur, Oren Shibolet, Stella Levit, David M Steinberg, Ophira Salomon
Up to now, there are no reliable biochemical markers or imaging that could reveal early tissue damage in Gaucher disease. Therefore, we addressed whether elastography technique can serve as a tool for evaluating patients with Gaucher disease. The study included 42 patients with Gaucher disease type I and 33 patients with liver cirrhosis as well as 22 healthy volunteers. Ultrasound and Doppler examination was performed on each participant prior to apply transient and 2D shear wave elastography. In Gaucher disease the median stiffness of the spleen as assessed by transient elastography (TE) and shear wave elastography (SWE) was 35KPa and 22KPa respectively in contrast to the median stiffness of healthy controls (16...
December 23, 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28017842/measurement-of-spleen-stiffness-with-acoustic-radiation-force%C3%A2-impulse-imaging-predicts-mortality-and-hepatic-decompensation-in-patients-with-liver-cirrhosis
#18
Yoshitaka Takuma, Youichi Morimoto, Hiroyuki Takabatake, Nobuyuki Toshikuni, Junko Tomokuni, Akiko Sahara, Kazuhiro Matsueda, Hiroshi Yamamoto
BACKGROUND & AIMS: Hepatic venous pressure gradient can predict mortality and hepatic decompensation in patients with cirrhosis. Measurement of hepatic venous pressure gradient requires an invasive procedure; therefore, prognostic markers are needed that do not require invasive procedures. We investigated whether measurements of spleen stiffness, made by acoustic radiation force impulse (ARFI) imaging, associated with mortality and decompensation in patients with cirrhosis, compared with liver stiffness and other markers...
November 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27859615/using-transient-elastography-to-predict-hepatocellular-carcinoma-recurrence-after-radiofrequency-ablation
#19
Yu Rim Lee, Soo Young Park, Seung Up Kim, Se Young Jang, Won Young Tak, Young Oh Kweon, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Keun Hur
BACKGROUND AND AIM: Liver stiffness (LS) value determined using transient elastography (TE) can be used to assess the degree of liver fibrosis. The study investigated whether TE can predict the recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). METHODS: This study retrospectively enrolled 228 patients with HCC who received TE and RFA as the first-line treatment for HCC between 2008 and 2015. Cox regression analysis was used to identify independent predictors of HCC recurrence...
May 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27829057/spleen-stiffness-is-superior-to-liver-stiffness-for-predicting-esophageal-varices-in-chronic-liver-disease-a-meta-analysis
#20
Xiaowen Ma, Le Wang, Hao Wu, Yuemin Feng, Xibiao Han, Haoran Bu, Qiang Zhu
BACKGROUND AND AIMS: Liver stiffness (LS) and spleen stiffness (SS) are two most widely accessible non-invasive parameters for predicting esophageal varices (EV), but the reported accuracy of the two predictors have been inconsistent across studies. This meta-analysis aims to evaluate the diagnostic performance of LS and SS measurement for detecting EV in patients with chronic liver disease (CLD), and compare their accuracy. METHODS: Pubmed/Medline, Embase, Cochrane Library and Ovid were searched for all studies assessing SS and LS simultaneously in EV diagnosis...
2016: PloS One
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