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spleen stiffness

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https://www.readbyqxmd.com/read/27859615/using-transient-elastography-to-predict-hepatocellular-carcinoma-recurrence-after-radiofrequency-ablation
#1
Yu Rim Lee, Soo Young Park, Seung Up Kim, Se Young Jang, Won Young Tak, Young Oh Kweon, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang Hyub Han, Keun Hur
BACKGROUND AND AIM: Liver stiffness (LS) value determined using transient elastography (TE) can be used to assess the degree of liver fibrosis. We investigated whether TE can predict the recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). METHODS: This study retrospectively enrolled 228 patients with HCC who received TE and RFA as the first-line treatment for HCC between 2008 and 2015. Cox regression analysis was used to identify independent predictors of HCC recurrence...
November 10, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27829057/spleen-stiffness-is-superior-to-liver-stiffness-for-predicting-esophageal-varices-in-chronic-liver-disease-a-meta-analysis
#2
Xiaowen Ma, Le Wang, Hao Wu, Yuemin Feng, Xibiao Han, Haoran Bu, Qiang Zhu
BACKGROUND AND AIMS: Liver stiffness (LS) and spleen stiffness (SS) are two most widely accessible non-invasive parameters for predicting esophageal varices (EV), but the reported accuracy of the two predictors have been inconsistent across studies. This meta-analysis aims to evaluate the diagnostic performance of LS and SS measurement for detecting EV in patients with chronic liver disease (CLD), and compare their accuracy. METHODS: Pubmed/Medline, Embase, Cochrane Library and Ovid were searched for all studies assessing SS and LS simultaneously in EV diagnosis...
2016: PloS One
https://www.readbyqxmd.com/read/27757311/targeting-myeloid-derived-suppressor-cells-using-a-novel-adenosine-monophosphate-activated-protein-kinase-ampk-activator
#3
Prashant Trikha, Robert L Plews, Andrew Stiff, Shalini Gautam, Vincent Hsu, David Abood, Robert Wesolowski, Ian Landi, Xiaokui Mo, John Phay, Ching-Shih Chen, John Byrd, Michael Caligiuri, Susheela Tridandapani, William Carson
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of early myeloid cells that accumulate in the blood and tumors of patients with cancer. MDSC play a critical role during tumor evasion and promote immune suppression through variety of mechanisms, such as the generation of reactive oxygen and nitrogen species (ROS and RNS) and cytokines. AMPactivated protein kinase (AMPK) is an evolutionarily conserved serine/threonine kinase that regulates energy homeostasis and metabolic stress. However, the role of AMPK in the regulation of MDSC function remains largely unexplored...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27756066/spleen-and-liver-stiffness-is-positively-correlated-with-the-risk-of-esophageal-variceal-bleeding
#4
Matthias Buechter, Alisan Kahraman, Paul Manka, Guido Gerken, Christoph Jochum, Ali Canbay, Alexander Dechêne
BACKGROUND/AIMS: Portal hypertension (PH) is a common complication of chronic liver disease and results in esophageal and gastric variceal bleeding, which is associated with a high mortality rate. Measurement of the hepatic venous pressure gradient (HVPG) is considered the gold standard for diagnosing PH and estimating the risk of varices and bleeding. In contrast, upper gastrointestinal (GI) endoscopy (UGE) can reliably demonstrate the presence of varices and bleeding. Both measures are invasive, and HVPG is mainly restricted to tertiary centers...
October 19, 2016: Digestion
https://www.readbyqxmd.com/read/27754054/os-15-02-matrix-metalloproteinase-2-knockout-protects-from-angiotensin-ii-induced-vascular-injury-in-part-via-inhibition-of-egfr-and-erk1-2-activation
#5
Pierre Paradis, Tlili Barhoumi, Muhammad Oneeb Rehman Mian, Julio C Fraulob-Aquino, Asia Rehman, Nourredine Idris-Khodja, Ernesto L Schiffrin
OBJECTIVE: Matrix metalloproteinase 2 (MMP2) is involved in cardiovascular disease. Whether MMP2 plays a role in hypertension and vascular damage is unknown. We hypothesized that Mmp2 knockout will prevent angiotensin (Ang) II-induced hypertension and vascular injury. DESIGN AND METHOD: Mmp2 knockout (Mmp2) and wild-type (WT) mice were infused with Ang II (1000 ng/kg/min, SC) for 14 days. Systolic blood pressure (SBP) was measured by telemetry, and mesenteric artery (MA) endothelial function and vascular remodeling by pressurized myography...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27699875/tomoelastography-of-the-abdomen-tissue-mechanical-properties-of-the-liver-spleen-kidney-and-pancreas-from-single-mr-elastography-scans-at-different-hydration-states
#6
Florian Dittmann, Heiko Tzschätzsch, Sebastian Hirsch, Eric Barnhill, Jürgen Braun, Ingolf Sack, Jing Guo
PURPOSE: To develop a compact magnetic resonance elastography (MRE) protocol for abdomen and to investigate the effect of water uptake on tissue stiffness in the liver, spleen, kidney, and pancreas. METHODS: Nine asymptomatic volunteers were investigated by MRE before and after 1 liter water uptake. Shear-wave excitation at four frequencies was transferred to the abdomen from anterior and posterior directions using pressurized air drivers. Tomographic representations of shear-wave speed were produced by analysis of multifrequency wave numbers in axial and coronal images acquired within four breath-holds or under free breathing, respectively...
October 3, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27672283/role-of-spleen-elastography-in-patients-with-chronic-liver-diseases
#7
REVIEW
Mariangela Giunta, Dario Conte, Mirella Fraquelli
The development of liver cirrhosis and portal hypertension (PH), one of its major complications, are structural and functional alterations of the liver, occurring in many patients with chronic liver diseases (CLD). Actually the progressive deposition of hepatic fibrosis has a key role in the prognosis of CLD patients. The subsequent development of PH leads to its major complications, such as ascites, hepatic encephalopathy, variceal bleeding and decompensation. Liver biopsy is still considered the reference standard for the assessment of hepatic fibrosis, whereas the measurement of hepatic vein pressure gradient is the standard to ascertain the presence of PH and upper endoscopy is the method of choice to detect the presence of oesophageal varices...
September 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27663656/liver-and-spleen-stiffness-measurements-by-point-shear-wave-elastography-via-acoustic-radiation-force-impulse-intraobserver-and-interobserver-variability-and-predictors-of-variability-in-a-us-population
#8
Maya Balakrishnan, Fernanda Souza, Carolina Muñoz, Salvador Augustin, Nicole Loo, Yanhong Deng, Maria Ciarleglio, Guadalupe Garcia-Tsao
OBJECTIVES: Measurements of liver stiffness and spleen stiffness are useful noninvasive ways to assess fibrosis and portal hypertension in patients with chronic liver disease. One method for assessing stiffness is by point shear wave elastography via acoustic radiation force impulse imaging (ARFI). Its advantage is that sites where stiffness is measured are visualized sonographically. However, its reliability has not been well established, and all studies done to date evaluating the use of ARFI in chronic liver disease have been performed outside the United States...
November 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27642974/os-15-02-matrix-metalloproteinase-2-knockout-protects-from-angiotensin-ii-induced-vascular-injury-in-part-via-inhibition-of-egfr-and-erk1-2-activation
#9
Pierre Paradis, Tlili Barhoumi, Muhammad Oneeb Rehman Mian, Julio C Fraulob-Aquino, Asia Rehman, Nourredine Idris-Khodja, Ernesto L Schiffrin
OBJECTIVE: Matrix metalloproteinase 2 (MMP2) is involved in cardiovascular disease. Whether MMP2 plays a role in hypertension and vascular damage is unknown. We hypothesized that Mmp2 knockout will prevent angiotensin (Ang) II-induced hypertension and vascular injury. DESIGN AND METHOD: Mmp2 knockout (Mmp2) and wild-type (WT) mice were infused with Ang II (1000 ng/kg/min, SC) for 14 days. Systolic blood pressure (SBP) was measured by telemetry, and mesenteric artery (MA) endothelial function and vascular remodeling by pressurized myography...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27639071/noninvasive-tools-and-risk-of-clinically-significant-portal-hypertension-and-varices-in-compensated-cirrhosis-the-anticipate-study
#10
Juan G Abraldes, Christophe Bureau, Horia Stefanescu, Salvador Augustin, Michael Ney, Hélène Blasco, Bogdan Procopet, Jaime Bosch, Joan Genesca, Annalisa Berzigotti
: In patients with compensated advanced chronic liver disease (cACLD), the presence of clinically significant portal hypertension (CSPH) and varices needing treatment (VNT) bears prognostic and therapeutic implications. Our aim was to develop noninvasive tests-based risk prediction models to provide a point-of-care risk assessment of cACLD patients. We analyzed 518 patients with cACLD from five centers in Europe/Canada with paired noninvasive tests (liver stiffness measurement [LSM] by transient elastography, platelet count, and spleen diameter with calculation of liver stiffness to spleen/platelet score [LSPS] score and platelet-spleen ratio [PSR]) and endoscopy/hepatic venous pressure gradient measurement...
September 17, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27569696/shear-wave-elastography-of-the-liver-and-spleen-identifies-clinically-significant-portal-hypertension-a-prospective-multi-center-study
#11
Christian Jansen, Christopher Bogs, Wim Verlinden, Maja Thiele, Philipp Möller, Jan Görtzen, Jennifer Lehmann, Thomas Vanwolleghem, Luisa Vonghia, Michael Praktiknjo, Johannes Chang, Aleksander Krag, Christian P Strassburg, Sven Francque, Jonel Trebicka
BACKGROUND AND AIMS: Clinically significant portal hypertension (CSPH) is associated with severe complications and decompensation of liver cirrhosis. Liver stiffness measured either by transient elastography (TE) or Shear-wave elastography (SWE) and spleen stiffness by TE might be helpful in the diagnosis of CSPH. We recently showed the algorithm to rule-out CSPH by using sequential liver- (L-SWE) and spleen-Shear-wave elastography (S-SWE). This study investigated the diagnostic value of S-SWE for diagnosis of CSPH...
August 29, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27567061/two-dimensional-time-harmonic-elastography-of-the-human-liver-and-spleen
#12
Heiko Tzschätzsch, Manh Nguyen Trong, Tobias Scheuermann, Selcan Ipek-Ugay, Thomas Fischer, Michael Schultz, Jürgen Braun, Ingolf Sack
Measurement of shear wave speed of the liver and spleen by elastography is an established diagnostic procedure for the detection of hepatic fibrosis, portal hypertension and esophageal varices. However, current elastography systems are limited by the size and penetration depth of elastographic windows. In this study, 2D time-harmonic elastography is proposed for generating full field-of-view shear wave speed maps in great depth. Two-dimensional time-harmonic elastography uses external harmonic stimulation at multiple frequencies to create compound shear wave speed maps...
November 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27529729/shear-wave-elastography-swe-of-the-spleen-in-patients-with-hepatitis-b-and-c-but-without-significant-liver-fibrosis
#13
Aleksander Pawluś, Marcin Inglot, Mariusz Chabowski, Kinga Szymańska, Małgorzata Inglot, Mateusz Patyk, Joanna Słonina, Filipe Caseiro-Alves, Dariusz Janczak, Urszula Zaleska-Dorobisz
OBJECTIVE: The aim of the study was to compare the elasticity of the spleen in patients with hepatitis B and C but without liver fibrosis with that of healthy subjects using a shear wave elastography (SWE) examination. METHODS: Between December 2014 and December 2015, 35 patients with hepatitis B virus (HBV) infections and 45 patients with (hepatitis C virus) HCV infections and liver stiffness below 7.1 kPa were included in the study. The control group was composed of 53 healthy volunteers without any chronic liver disease, with no abnormal findings in their ultrasound examinations and with an SWE of the liver below 6...
October 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27500382/regression-of-fibrosis-and-portal-hypertension-in-hcv-associated-cirrhosis-and-sustained-virologic-response-after-interferon-free-antiviral-therapy
#14
V Knop, D Hoppe, T Welzel, J Vermehren, E Herrmann, A Vermehren, M Friedrich-Rust, C Sarrazin, S Zeuzem, M-W Welker
It is still controversial, whether and to what amount cirrhosis and portal hypertension are reversible in patients with hepatitis C virus (HCV)-associated cirrhosis and sustained virologic response (SVR) after interferon-free antiviral therapy. In this study, we prospectively evaluated dynamics of liver and spleen stiffness in HCV-infected patients with advanced liver disease and SVR after interferon-free treatment. A total of 54 patients with HCV-associated cirrhosis and SVR were included. Liver and spleen stiffness was measured at therapy baseline (BL), end of treatment (EOT) and 24 weeks after EOT (FU24) by transient liver elastography (L-TE) as well as by acoustic radiation force impulse of the liver (L-ARFI) and spleen (S-ARFI), as well as biochemical, virologic and clinical data...
August 8, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27488328/new-combined-parameter-of-liver-and-splenic-stiffness-as-determined-by-elastography-in-healthy-volunteers
#15
Laura Kassym, Mohammed A Nounou, Zauresh Zhumadilova, Asad I Dajani, Nurgul Barkibayeva, Ayan Myssayev, Tolebay Rakhypbekov, Adnan M Abuhammour
BACKGROUND: The diagnosis of chronic liver disease (CLD) leading to fibrosis, cirrhosis, and portal hypertension had witnessed dramatic changes after the introduction of noninvasive figure accessible tools over the past few years. Imaging techniques that are based on evaluation of the liver stiffness was particularly useful in this respect. Acoustic radiation force impulse (ARFI) emerged as an interesting figure tool with reliable repute and high precision. AIMS: To evaluate liver stiffness measurement (LSM) and splenic stiffness measurement (SSM) in healthy volunteers as concluded by the ARFI technique and to out a numeric calculated ratio that may reflect their correlation in the otherwise healthy liver...
July 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27475617/non-invasive-assessment-of-portal-hypertension-using-quantitative-magnetic-resonance-imaging
#16
Naaventhan Palaniyappan, Eleanor Cox, Christopher Bradley, Robert Scott, Andrew Austin, Richard O'Neill, Greg Ramjas, Simon Travis, Hilary White, Rajeev Singh, Peter Thurley, Indra Neil Guha, Susan Francis, Guruprasad Padur Aithal
BACKGROUND & AIMS: Hepatic venous pressure gradient (HVPG) measurement is currently the only validated technique to accurately evaluate changes in portal pressure. In this study, we evaluate the use of non-contrast quantitative magnetic resonance imaging (MRI) as a surrogate measure of portal pressure. METHODS: Thirty patients undergoing HVPG measurement were prospectively recruited. MR parameters of longitudinal relaxation time (T1), perfusion of the liver and spleen (by arterial spin labelling), and blood flow in the portal, splanchnic and collateral circulation (by phase contrast MRI) were assessed...
December 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27401609/elasticity-mapping-of-murine-abdominal-organs-in-vivo-using-harmonic-motion-imaging-hmi
#17
Thomas Payen, Carmine F Palermo, Stephen A Sastra, Hong Chen, Yang Han, Kenneth P Olive, Elisa E Konofagou
Recently, ultrasonic imaging of soft tissue mechanics has been increasingly studied to image otherwise undetectable pathologies. However, many underlying mechanisms of tissue stiffening remain unknown, requiring small animal studies and adapted elasticity mapping techniques. Harmonic motion imaging (HMI) assesses tissue viscoelasticity by inducing localized oscillation from a periodic acoustic radiation force. The objective of this study was to evaluate the feasibility of HMI for in vivo elasticity mapping of abdominal organs in small animals...
August 7, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27398275/liver-stiffness-spleen-size-to-platelet-ratio-risk-score-detects-esophageal-varices-in-chronic-liver-disease
#18
Soichiro Shibata, Satoru Joshita, Takeji Umemura, Tomoo Yamazaki, Naoyuki Fujimori, Yuki Ichikawa, Michiharu Komatsu, Akihiro Matsumoto, Eiji Tanaka
BACKGROUND: Noninvasive markers are needed to identify esophageal varices (EV) in patients with chronic liver disease (CLD). Recently, liver stiffness (LS)-spleen size-to-platelet ratio risk score (LSPS) has been shown to predict EV in patients with chronic hepatitis C. The aim of this study was to validate the clinical value of LSPS for EV detection and identification of high risk EV in Japanese patients with CLD. METHODS: A total of 230 patients with CLD who had undergone endoscopy, LS measurement, and ultrasonography between 2013 and 2015 were enrolled...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27389244/shear-wave-elastography-of-the-spleen-evaluation-of-spleen-stiffness-in-healthy-volunteers
#19
Aleksander Pawluś, Marcin S Inglot, Kinga Szymańska, Krzysztof Kaczorowski, Bartosz D Markiewicz, Agnieszka Kaczorowska, Jacek Gąsiorowski, Aleksandra Szymczak, Małgorzata Inglot, Joanna Bladowska, Urszula Zaleska-Dorobisz
PURPOSE: The aim of this study was to assess the mean value of spleen stiffness measured by Shear wave elastography in healthy patients and its dependence on age, sex, and spleen dimensions, and to evaluate the repeatability of this method. METHODS: The final study group included 59 healthy volunteers without any clinical evidence of liver disease, portal hypertension, hematological disorders, and without any pathological ultrasonographic spleen findings. Each patient underwent abdominal ultrasound examination and elastography of the liver and the spleen...
July 7, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27371373/transient-elastography-for-spleen-stiffness-measurement-in-patients-with-cirrhosis-role-in-degree-of-thrombocytopenia
#20
Cheng-Hung Chien, Yi-Lan Lin, Rong-Nan Chien, Ching-Chih Hu, Cho-Li Yen, Tsung-Shih Lee, Po-Jen Hsieh, Chih-Lang Lin
OBJECTIVES: The purpose of our study was to evaluate the relationship between spleen stiffness measured by transient elastography and the degree of thrombocytopenia in patients with liver cirrhosis. METHODS: A total of 67 patients with liver cirrhosis were prospectively enrolled in the study. All patients underwent single-day hematologic and biochemical tests, sonography, and transient elastography of the liver and spleen. Thrombocytopenia was categorized as mild (platelet count, 75,000-150,000/μL), moderate (50,000-75,000/μL), and severe (<50,000/μL)...
September 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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