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Follicular lymphoma elderly

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https://www.readbyqxmd.com/read/28340875/angioimmunoblastic-t-cell-lymphoma
#1
REVIEW
Alessandro Broccoli, Pier Luigi Zinzani
Angioimmunoblastic T-cell lymphoma is a follicular T-helper-derived neoplasm displaying a peculiar morphologic appearance and biological complexity. New mutations have been described that contribute to elucidating the underlying pathogenetic events. The disease behaves aggressively and typically affects elderly patients. The outcomes reported with anthracycline-containing regimens are poor; therefore autologous transplantation in first remission should be offered whenever possible. Newer approaches are urgently needed for relapsed and refractory patients...
April 2017: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/28215641/coexistence-of-age-related-ebv-associated-follicular-hyperplasia-and-large-b-cell-ebv-lymphoma-of-the-elderly-two-distinct-features-of-the-same-t-cell-dysfunction-related-to-senescence
#2
Jean-Baptiste Gibier, Brigitte Bouchindhomme, Romain Dubois, Benedicte Hivert, Nathalie Grardel, Marie-Christine Copin
Age-related EBV-associated lymphoproliferative disorders form a new clinicopathological group. Until recently, this group was associated with diffuse large B-cell lymphoma (DLBCL), characterised by an aggressive clinical presentation and a poor prognosis. Recent findings in Western Caucasian patients, however, suggest that this entity covers a wide spectrum of diseases, ranging from reactive follicular hyperplasia (HR) to DLBCL. We report the case of an 85-year-old Caucasian man showing lymphadenopathy and numerous hypodense lesions of the liver...
March 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28197348/angioimmunoblastic-t-cell-lymphoma-a-questionable-association-with-follicular-dendritic-cell-sarcoma
#3
Daniel Benharroch, Miriam Zekzer, Karen Nalbandyan
An elderly woman presented with generalized lymphadenopathy, several systemic symptoms, and splenomegaly. An inguinal lymph node excision revealed a compound picture. One aspect of the lymph node morphology, including cells with follicular T-helper cell phenotype, was most consistent with angioimmunoblastic T-cell lymphoma. The other component, revealing spindle cells forming whorls with immunostaining for CD21, CD23, and fascin, might be an integral part of this T-cell lymphoma. However, due to the often massive involvement of the nodal tissue by these follicular dendritic cells, these areas were questionably suggestive of involvement by follicular dendritic cell sarcoma...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/28156055/combination-of-rituximab-and-nonpegylated-liposomal-doxorubicin-r-npld-as-front-line-therapy-for-aggressive-non-hodgkin-lymphoma-nhl-in-patients-80%C3%A2-years-of-age-or-older-a-single-center-retrospective-study
#4
Giuseppina Ricciuti, Erica Finolezzi, Stefania Luciani, Elena Ranucci, Massimo Federico, Marta Di Nicola, Isaia Antonio Luca Zecca, Francesco Angrilli
The incidence of non-Hodgkin lymphoma in patients 80 years of age or older is 50 times higher than in 20- to 24-year-olds. Very elderly patients are often not treated with standard immunochemotherapy because of poor performance status, comorbidities, and toxicity concerns. We retrospectively analyzed data for 29 patients diagnosed with diffuse large B-cell lymphoma or grade 3B follicular lymphoma and treated with rituximab in combination with nonpegylated liposomal doxorubicin between January 2010 and August 2015...
February 3, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28125450/clinicopathological-study-of-30-cases-of-peripheral-t-cell-lymphoma-with-hodgkin-and-reed-sternberg-like-b-cells-from-japan
#5
Ahmed E Eladl, Akira Satou, Ahmed Ali Elsayed, Yuka Suzuki, Seiichi Kato, Naoko Asano, Shigeo Nakamura
The presence of Hodgkin and Reed-Sternberg (HRS)-like B-cells in peripheral T-cell lymphoma (PTCL) is rare and its clinicopathological features still remain unclear. Here, we describe 30 cases of PTCL with HRS-like B-cells from Japan. Twenty-three cases (77%) presented evidence of follicular T-helper phenotype (TFH) derivation: 12 were angioimmunoblastic T-cell lymphoma and 11 PTCL with TFH phenotype (PTCL-TFH). The remaining seven cases were diagnosed as PTCL, not otherwise specified (PTCL-NOS). Epstein-Barr virus (EBV) reactivation was detected in 25 cases (83%), but HRS-like B-cells were EBER in only 20 cases (67%)...
April 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28105297/follicular-lymphoma-the-management-of-elderly-patient
#6
REVIEW
Alessia Castellino, Elisa Santambrogio, Maura Nicolosi, Barbara Botto, Carola Boccomini, Umberto Vitolo
Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma, which typically affects mature adults and elderly, whose median age at diagnosis is 65 years. The natural history of FL appears to have been favorably impacted by the introduction of Rituximab. Randomized clinical trials demonstrated that the addition of rituximab to standard chemotherapy induction has improved the overall survival and new strategies of chemo-immunotherapy, such as Bendamustine combined with Rituximab, showed optimal results on response and reduced hematological toxicity, becoming one of the standard treatments, particularly in elderly patients...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27897411/skeletal-muscle-density-is-an-independent-predictor-of-diffuse-large-b-cell-lymphoma-outcomes-treated-with-rituximab-based-chemoimmunotherapy
#7
Michael P Chu, Jessica Lieffers, Sunita Ghosh, Andrew Belch, Neil S Chua, Amelie Fontaine, Randeep Sangha, Robert A Turner, Vickie E Baracos, Michael B Sawyer
BACKGROUND: While much cancer research focuses on tumours and their microenvironment, malignancies cause widespread physiologic changes. Cancer and treatment-related sarcopenia, measured with quantitative imaging or as a decrease in overall body mass, are indicative of poor prognosis in elderly diffuse large B-cell lymphoma (DLBCL) patients, skeletal muscle radiodensity (SMD) may be a better prognostic marker. SMD, a measure of muscle radiation attenuation on CT imaging, is more prognostic than sarcopenia or International Prognostic Index (IPI) scores in follicular lymphoma and multiple solid organ malignancies...
November 21, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27872740/follicular-lymphoma-a-clinicopathological-analysis-from-a-tertiary-care-institute-in-southern-india
#8
Mary Theresa Sylvia, Biswajit Dey, Debdatta Basu, Sajini Elizabeth Jacob, Rakhee Kar, Biswajit Dubashi
INTRODUCTION: Follicular lymphoma (FL) is an indolent lymphoproliferative disorder of B-cells with variable clinical behavior. It is the second most common subtype of Non-Hodgkin lymphoma in western countries but reported to have a lower incidence in Asia. MATERIALS AND METHODS: Cases of FL diagnosed in the Department of Pathology of our Institute from January 2009 to June 2015 were included in the study. The clinicopathological parameters including staging, histological details, and immunohistochemical markers CD20, CD10 and BCL-2 were recorded in all the cases...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27830968/patterns-of-use-and-survival-outcomes-of-positron-emission-tomography-for-initial-staging-in-elderly-follicular-lymphoma-patients
#9
Ashish Rai, Loretta J Nastoupil, Jessica N Williams, Joseph Lipscomb, Kevin C Ward, David H Howard, Daniel Lee, Christopher R Flowers
The role of positron emission tomography (PET) in the initial assessment of follicular lymphoma (FL) has been a topic of debate. We examined the patterns of utilization of PET staging in FL and assessed the association of PET with survival. Using the SEER-Medicare database, we identified 5712 patients diagnosed with first primary FL between 2000 and 2009. Older age, African-American race, poor performance status, B-symptoms and history of anemia were negatively associated with PET staging. Receipt of PET staging was positively associated with treatment at institutions affiliated with research networks and with residence in areas with higher concentrations of nuclear medicine specialists...
July 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27614527/-radiotherapy-in-localized-stages-of-follicular-and-diffuse-non-hodgkin-s-lymphomas
#10
REVIEW
C Demoor-Goldschmidt, P Agape, I Barillot, M A Mahé
Treatment with monoclonal antibodies, especially rituximab, is more and more frequent and questions the interest of radiotherapy in limited stages of diffuse B-cell large cell and follicular non-Hodgkin's lymphomas. From a review of literature, it appears that radiotherapy is of interest in bulky disease, patients with incomplete metabolic response, elderly patients receiving short chemotherapy and those with recurrence after exclusive chemotherapy. Finally, this article gives recommendations on available techniques of radiotherapy and doses to be delivered...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27597921/polymyalgia-rheumatica-revealing-a-lymphoma-a-two-case-report
#11
Frank Verhoeven, Xavier Guillot, Mickaël Chouk, Clément Prati, Daniel Wendling
Introduction. Polymyalgia rheumatica (PMR) is one of the most common inflammatory rheumatism types in elderly population. The link between cancer and PMR is a matter of debate. Methods. We report two cases of PMR leading to the diagnosis of lymphoma and the growing interest of PET-TDM in this indication. Results. A 84-year-old man known for idiopathic neutropenia presented an inflammatory arthromyalgia of the limb girdle since one month. Blood exams highlighted the presence of a monoclonal B cell clone. Bone marrow concluded to a B cell lymphoma of the marginal zone...
2016: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/27413523/bendamustine-and-rituximab-as-first-line-treatment-in-intermediate-high-risk-splenic-marginal-zone-lymphomas-of-elderly-patients
#12
Roberto Castelli, Antonio Gidaro, Giorgio Lambertenghi Deliliers
BACKGROUND: Splenic marginal zone lymphoma (SMZL) is a chronic B-cell lymphoproliferative disorder, comprising less than 2% of non-Hodgkin's lymphomas, and affecting mainly middle-aged and elderly patients with a median survival of >10 years. The typical clinical features of SMZL include splenomegaly. Treatment should be patient-tailored and can range from a 'watchful waiting' approach for asymptomatic patients without cytopenias to surgery, localized radiation therapy or immuno/chemotherapies...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27236576/core-needle-biopsies-and-surgical-excision-biopsies-in-the-diagnosis-of-lymphoma-experience-at-the-lymph-node-registry-kiel
#13
Alice Johl, Eva Lengfelder, Wolfgang Hiddemann, Wolfram Klapper
Current guidelines of the European Society of Medical Oncology recommend surgical excision biopsies of lymph nodes for the diagnosis of lymphoma whenever possible. However, core needle biopsies are increasingly used. We aimed to understand the common practice to choose the method of biopsy in Germany. Furthermore, we wanted to understand performance of surgical excision and core needle biopsies of lymph nodes in the diagnosis of lymphoma. The files of 1510 unselected, consecutive lymph node specimens from a consultation center for lymphoma diagnosis were analyzed...
August 2016: Annals of Hematology
https://www.readbyqxmd.com/read/26657116/90-y-ibritumomab-tiuxetan-a-nearly-forgotten-opportunityr
#14
REVIEW
Patrizia Mondello, Salvatore Cuzzocrea, Michele Navarra, Michael Mian
Y-ibritumomab tiuxetan (90Y-IT) combines the benefits of a monoclonal antibody with the efficacy of radiation in the treatment of B-cell non-Hodgkin lymphoma (NHL), a remarkably radiosensitive hematologic malignancy. 90Y-IT activity has been well established in the indolent setting, being approved in front-line treatment of follicular lymphoma (FL) patients as well as salvage therapy. However, no advantage in OS was observed with respect to standard treatment. Promising data are available also for aggressive B-cell lymphoma...
February 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/26463529/outcomes-of-very-elderly-patients-with-aggressive-b-cell-non-hodgkin-lymphoma-treated-with-reduced-dose-chemotherapy
#15
Futoshi Iioka, Kiyotaka Izumi, Yoshimasa Kamoda, Takashi Akasaka, Hitoshi Ohno
BACKGROUND: Although the number of patients aged 80 years or older with aggressive B-cell non-Hodgkin lymphoma (B-NHL) has increased in the clinical setting, management has been challenging due to lower tolerability. The aim of the present study was to evaluate the efficacy and safety of reduced-dose chemotherapy for very elderly patients. METHODS: We retrospectively analyzed the clinical outcomes of patients aged ≥80 years old with diffuse large B-cell lymphoma (n = 58) or grade 3 follicular lymphoma (n = 3)...
June 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/26352106/the-long-term-efficacy-and-safety-of-fecal-microbiota-transplant-for-recurrent-severe-and-complicated-clostridium-difficile-infection-in-146-elderly-individuals
#16
MULTICENTER STUDY
Manasi Agrawal, Olga C Aroniadis, Lawrence J Brandt, Colleen Kelly, Sarah Freeman, Christina Surawicz, Elizabeth Broussard, Neil Stollman, Andrea Giovanelli, Becky Smith, Eugene Yen, Apurva Trivedi, Levi Hubble, Dina Kao, Thomas Borody, Sarah Finlayson, Arnab Ray, Robert Smith
OBJECTIVES: Clostridium difficile infection (CDI) in the elderly has a higher prevalence, greater morbidity and mortality, and lower response to conventional treatment than the general population. Fecal microbiota transplant (FMT) is highly effective therapy for CDI but has not been studied specifically in the elderly. This study aims to determine the long-term efficacy and safety of FMT for recurrent (RCDI), severe (SCDI), and complicated (CCDI) CDI in elderly patients. METHODS: A multicenter, long-term follow-up study was performed with demographic, pre-FMT, and post-FMT data collected from elderly patients with RCDI, SCDI, and CCDI, through a 47-item questionnaire...
May 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/26116168/autologous-hematopoietic-stem-cell-transplantation-in-elderly-patients-%C3%A2-70-years-with-non-hodgkin-s-lymphoma-a-french-society-of-bone-marrow-transplantation-and-cellular-therapy-retrospective-study
#17
MULTICENTER STUDY
E Hermet, A Cabrespine, R Guièze, A Garnier, A Tempescul, P Lenain, R Bouabdallah, J P Vilque, J Frayfer, D Bordessoule, D Sibon, M Janvier, D Caillot, P Biron, L Legros, B Choufi, B Drenou, N C Gorin, K Bilger, J Tamburini, C Soussain, S Brechignac, J O Bay
INTRODUCTION: Limited data is available on the feasibility of high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (AHSCT) in elderly patients over 70 years of age with non-Hodgkin's lymphoma (NHL). MATERIALS AND METHODS: In the setting of the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC) group, we retrospectively analyzed 81 consecutive patients with NHL over 70 years of age who received AHSCT. RESULTS: The median age at AHSCT was 72...
September 2015: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/25851937/disease-characteristics-treatment-patterns-prognosis-outcomes-and-lymphoma-related-mortality-in-elderly-follicular-lymphoma-in-the-united-states
#18
MULTICENTER STUDY
Chadi Nabhan, Michelle Byrtek, Ashish Rai, Keith Dawson, Xiaolei Zhou, Brian K Link, Jonathan W Friedberg, Andrew D Zelenetz, Matthew J Maurer, James R Cerhan, Christopher R Flowers
Data from the National LymphoCare Study (a prospective, multicentre registry that enrolled follicular lymphoma (FL) patients from 2004 to 2007) were used to determine disease characteristics, treatment patterns, outcomes and prognosis for elderly FL (eFL) patients. Of 2650 FL patients, 209 (8%) were aged >80 years; these eFL patients more commonly had grade 3 disease, less frequently received chemoimmunotherapy and anthracyclines, and had lower response rates when compared to younger patients. With a median follow-up of 6...
July 2015: British Journal of Haematology
https://www.readbyqxmd.com/read/25841714/individualized-management-of-follicular-lymphoma
#19
REVIEW
Bing Bai, Hui-Qiang Huang
Follicular lymphoma (FL) is the most common indolent non-hodgkin lymphoma. Most patients with FL are diagnosed with advanced disease and are considered incurable. The classical prognostic index in FL is the FL international prognostic index (FLIPI). The management of FL is mainly determined by histologic grading, clinical stage, and tumor burden. For patients with stage I and II disease, an involved-site radiation therapy (ISRT) is recommended and may be potentially curative approach with 60% to 80% of 10-year overall survival (OS) rates, while patients with stage III and IV should be treated with systemic therapy...
March 2015: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/25670221/idelalisib-first-in-class-pi3k-delta-inhibitor-for-the-treatment-of-chronic-lymphocytic-leukemia-small-lymphocytic-leukemia-and-follicular-lymphoma
#20
REVIEW
Qingshan Yang, Prexy Modi, Terry Newcomb, Christophe Quéva, Varsha Gandhi
Idelalisib [Zydelig (Gilead Sciences, Inc.), also known as CAL-101 and GS-1101] was approved in 2014 in the United States and European Union for the treatment of three indolent B-cell neoplasms: relapsed/refractory chronic lymphocytic leukemia (CLL, in combination with rituximab), relapsed follicular lymphoma, and relapsed small lymphocytic lymphoma (as monotherapy). Furthermore, it was approved in the European Union as first-line therapy for poor-prognosis CLL with 17p deletions or TP53 mutations and in patients unsuitable for chemoimmunotherapy...
April 1, 2015: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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