keyword
https://read.qxmd.com/read/38442703/advancements-in-hla-typing-techniques-and-their-impact-on-transplantation-medicine
#21
REVIEW
Jeethu Anu Geo, Reem Ameen, Salem Al Shemmari, Jibu Thomas
HLA typing serves as a standard practice in hematopoietic stem cell transplantation to ensure compatibility between donors and recipients, preventing the occurrence of allograft rejection and graft-versus-host disease. Conventional laboratory methods that have been widely employed in the past few years, including Sequence-Specific Primer PCR and Sequencing Based Typing (SBT), currently face the risk of becoming obsolete. This risk stems not only from the extensive diversity within HLA genes but also from the rapid advancement of Next Generation Sequencing and third-generation sequencing technologies...
March 5, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38433707/discovery-of-the-novel-hla-a-01-01-01-112-allele-in-a-greek-volunteer-bone-marrow-donor
#22
JOURNAL ARTICLE
Diamanto Kouniaki, Vasiliki Kitsiou, Alexandra Tsirogianni
HLA-A*01:01:01:112 differs from the HLA-A*01:01:01:01 allele by one nucleotide substitution in the 5'UTR.
March 2024: HLA
https://read.qxmd.com/read/38433683/genomic-sequence-of-the-novel-hla-b-41-02-01-11-and-c-08-266-alleles-identified-in-a-solid-organ-recipient
#23
JOURNAL ARTICLE
Diamanto Kouniaki, Konstantinos Fotopoulos, Alexandra Tsirogianni
HLA-B*41:02:01:11 and -C*08:266 were detected in a solid organ recipient during the HLA typing process.
March 2024: HLA
https://read.qxmd.com/read/38433661/full-length-sequence-of-the-novel-allele-hla-b-58-01-40-identified-in-a-chinese-individual
#24
JOURNAL ARTICLE
Fan Yang, Long Peng, Su-Qing Gao
HLA-B*58:01:40 differs from HLA-B*58:01:01 by a single nucleotide change in exon 3, 507 C- > T (codon 145.3 CGC- > CGT).
March 2024: HLA
https://read.qxmd.com/read/38433656/four-new-intronic-variants-of-hla-dqb1-detected-by-next-generation-sequencing
#25
JOURNAL ARTICLE
Luis Alberto Marín Rubio, Jesús Ontañón
Characterization of HLA-DQB1*02:02:01:18, -DQB1*02:02:01:19, -DQB1*03:02:01:20 and -DQB1*05:03:01:10 alleles in Spanish individuals.
March 2024: HLA
https://read.qxmd.com/read/38432114/genomic-profiles-and-their-relationships-with-clinical-characteristics-and-immune-features-in-cervical-cancer
#26
JOURNAL ARTICLE
Zinan Lu, Peiwen Fan, Wen Huo, Yaning Feng, Ruozheng Wang
OBJECTIVE: This study aimed to investigate the genomic alteration profiles of cervical cancer patients, examine the correlation between mutation patterns and clinical and immune attributes, and discover novel targets for treatment of individuals with cervical cancer. METHODS: We performed targeted next-generation sequencing of tumor tissues and blood samples obtained from 45 cervical cancer patients to analyze somatic alterations, mutation patterns, and HLA alleles comprehensively...
March 2, 2024: Translational Oncology
https://read.qxmd.com/read/38429643/single-cell-rna-sequencing-reveals-peripheral-blood-leukocyte-responses-to-spinal-cord-injury-in-mice-with-humanised-immune-systems
#27
JOURNAL ARTICLE
Ellen R Gillespie, Laura F Grice, Isabel G Courtney, Hong Wa Lao, Woncheol Jung, Sonny Ramkomuth, Jacky Xie, David A Brown, James Walsham, Kristen J Radford, Quan H Nguyen, Marc J Ruitenberg
Next-generation humanised mouse models and single-cell RNA sequencing (scRNAseq) approaches enable in-depth studies into human immune cell biology. Here we used NSG-SGM3 mice engrafted with human umbilical cord haematopoietic stem cells to investigate how human immune cells respond to and/or are changed by traumatic spinal cord injury (SCI). We hypothesised that the use of such mice could help advance our understanding of spinal cord injury-induced immune depression syndrome (SCI-IDS), and also how human leukocytes change as they migrate from the circulation into the lesion site...
March 1, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38407762/polymorphisms-in-innate-and-adaptive-immune-genes-in-subjects-with-allergic-bronchopulmonary-aspergillosis-complicating-asthma
#28
JOURNAL ARTICLE
Rimjhim Kanaujia, Amit Arora, Arunaloke Chakrabarti, Shivaprakash M Rudramurthy, Ritesh Agarwal
Innate and adaptive immunity play a crucial role in allergic bronchopulmonary aspergillosis (ABPA) pathogenesis. We performed next-generation sequencing using the Illumina TruSight One panel (4,811 human disease-associated genes, at least 20 × coverage) and selected 22 known immune genes (toll-like receptors (TLRs), C-type lectin, interleukin-4 receptor, and others). We included ABPA (n = 18), asthma without ABPA (n = 12), and healthy controls (n = 8)...
February 26, 2024: Mycopathologia
https://read.qxmd.com/read/38405747/virus-free-crispr-knock-in-of-a-chimeric-antigen-receptor-into-klrc1-generates-potent-gd2-specific-natural-killer-cells
#29
Keerthana Shankar, Isabella Zingler-Hoslet, Lei Shi, Varun Katta, Brittany E Russell, Shengdar Q Tsai, Christian M Capitini, Krishanu Saha
Natural killer (NK) cells are an appealing off-the-shelf, allogeneic cellular therapy due to their cytotoxic profile. However, their activity against solid tumors remains suboptimal in part due to the upregulation of NK-inhibitory ligands, such as HLA-E, within the tumor microenvironment. Here, we utilize CRISPR-Cas9 to disrupt the KLRC1 gene (encoding the HLA-E-binding NKG2A receptor) and perform non-viral insertion of a GD2-targeting chimeric antigen receptor (CAR) within NK cells isolated from human peripheral blood...
February 14, 2024: bioRxiv
https://read.qxmd.com/read/38403859/characterization-of-the-novel-hla-dpa1-02-124-allele-in-a-korean-individual-by-next-generation-sequencing
#30
JOURNAL ARTICLE
Soong Ki Roh, Dong Il Won
HLA-DPA1*02:124 differs from HLA-DRB1*02:02:02:01 by one nucleotide substitution in codon 5 in exon 2.
February 2024: HLA
https://read.qxmd.com/read/38403836/discovery-of-three-hla-dqb1-03-01-01-variants-hla-dqb1-03-01-01-54-dqb1-03-01-01-56-and-dqb1-03-01-01-58
#31
JOURNAL ARTICLE
Daniel Arroyo-Sánchez, Francisco Javier Gil-Etayo, Jairo Eduardo Niño Ramírez, Pilar Terradillos-Sánchez, Amalia Tejeda Velarde
Three nucleotide substitutions in intronic regions give rise to the novel alleles: HLA-DQB1*03:01:01:54, -DQB1*03:01:01:56, -DQB1*03:01:01:58.
February 2024: HLA
https://read.qxmd.com/read/38392185/molecular-analysis-of-hla-genes-in-romanian-patients-with-chronic-hepatitis-b-virus-infection
#32
JOURNAL ARTICLE
Adriana Tălăngescu, Bogdan Calenic, Dan Florin Mihăilescu, Maria Tizu, Ion Marunțelu, Alexandra E Constantinescu, Ileana Constantinescu
Hepatitis B, a persistent inflammatory liver condition, stands as a significant global health issue. In Romania, the prevalence of chronic hepatitis B virus (CHB) infection ranks among the highest in the European Union. The HLA genotype significantly impacts hepatitis B virus infection progression, indicating that certain HLA variants can affect the infection's outcome. The primary goal of the present work is to identify HLA alleles and specific amino acid residues linked to hepatitis B within the Romanian population...
January 24, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38372620/identification-of-the-novel-hla-c-01-65-02-allele-by-next-generation-sequencing
#33
JOURNAL ARTICLE
Juan López-Pérez, Luis Martínez-Lostao, Mercedes Inda-Landaluce
The novel HLA-C*01:65:02 allele was detected during routine HLA typing.
February 2024: HLA
https://read.qxmd.com/read/38372613/two-novel-hla-drb3-alleles-identified-in-brazilian-bone-marrow-donors-hla-drb3-01-122-and-drb3-01-123
#34
JOURNAL ARTICLE
Anthony Marçal Leão de Oliveira, Fernanda Pelisson Massi, Larissa Danielle Bahls Pinto, Quirino Alves de Lima Neto, Jeane Eliete Laguila Visentainer
We identified two new HLA-DRB3 alleles in Brazilian individuals using next generation sequencing.
February 2024: HLA
https://read.qxmd.com/read/38372583/characterization-of-the-novel-hla-dqb1-03-516-allele-by-next-generation-sequencing
#35
JOURNAL ARTICLE
Cheng Bian, Zi-Hao Wang, Zi-An Cheng, Hao Sun, Zhao-Qing Yang
HLA-DQB1*03:516 differs from DQB1*03:03:02:03 by one nucleotide substitution at position 197G>A in exon 2.
February 2024: HLA
https://read.qxmd.com/read/38372571/next-generation-sequencing-identifies-four-novel-hla-class-i-alleles-with-nucleotide-substitutions-in-the-3-utr
#36
JOURNAL ARTICLE
Jairo Eduardo Niño Ramírez, Francisco Javier Gil-Etayo, Isabel Jiménez Hernaz, Daniel Arroyo-Sánchez, Amalia Tejeda Velarde
Characterization by next-generation sequencing of four novel HLA alleles: C*17:03:01:07, C*16:01:01:39, B*15:17:01:07, and B*44:03:01:57.
February 2024: HLA
https://read.qxmd.com/read/38358088/a-single-nucleotide-substitution-in-intron-3-generated-the-novel-hla-a-11-01-01-68-allele
#37
JOURNAL ARTICLE
Akanksha Sharma, Soumita Bagchi, Adarsh W Barwad, Sanjay Kumar Agarwal, Uma Kanga
HLA-A*11:01:01:68 differs from HLA-A*11:01:01:01 by one nucleotide change in intron 3 at position 1474 (G > A).
February 2024: HLA
https://read.qxmd.com/read/38358085/identification-of-the-novel-hla-c-03-132-02-allele-in-a-chinese-individual-by-next-generation-sequencing
#38
JOURNAL ARTICLE
Ziqing Wang, Yamin Sun, Yiqing Kang, Jianbin Li, Zheng Liu
Compared with the HLA-C*03:132:01 allele, HLA-C*03:132:02 shows one nucleotide substitution at position 270A>C.
February 2024: HLA
https://read.qxmd.com/read/38358076/characterization-of-seven-novel-hla-dpa1-01-03-01-non-coding-variants-by-next-generation-sequencing
#39
JOURNAL ARTICLE
Francisco Javier Gil-Etayo, Jairo Eduardo Niño Ramírez, Ariadna Vicente Parra, Daniel Arroyo-Sánchez, Amalia Tejeda Velarde
Seven different single nucleotide substitutions in non-coding regions gave rise to novel HLA-DPA1*01:03:01 variants.
February 2024: HLA
https://read.qxmd.com/read/38358022/characterization-of-the-novel-hla-b-57-169-allele-by-next-generation-sequencing
#40
JOURNAL ARTICLE
Chris Gravante, Yacine Berka, Lindsey Peters, Shannon Mancini, Abdelhamid Liacini
HLA-B*57:169 differs from HLA-B*57:01:01:12 by one nucleotide substitution at position 2512, codon 320 located in exon 6.
February 2024: HLA
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