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https://www.readbyqxmd.com/read/27875420/molecular-imaging-in-neuroendocrine-tumors-recent-advances-controversies-unresolved-issues-and-roles-in-management
#1
Tetsuhide Ito, Robert T Jensen
PURPOSE OF REVIEW: The purpose is to review recent advances in molecular imaging of neuroendocrine tumors (NETs), discuss unresolved issues, and review how these advances are affecting clinical management. RECENT FINDINGS: Molecular imaging of NETs underwent a number of important changes in the last few years, leading to some controversies, unresolved issues, and significant changes in clinical management. The most recent changes are reviewed in this article. Particularly important is the rapid replacement in somatostatin receptor scintigraphy of In-diethylenetriamine penta-acetic acid-single-photon emission computed tomography/computed tomography (CT) by Ga-fluorodopa(F-D)PA), 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-peptide-PET/CT imaging, which is now approved in many countries including the USA...
November 21, 2016: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/27869179/interleukins-17-and-23-in-patients-with-gastric-neoplasms
#2
Wojciech Błogowski, Anna Madej-Michniewicz, Natalia Marczuk, Barbara Dołęgowska, Teresa Starzyńska
Recently there has been heightened interest in the potential significance of interleukin (IL)-17 and IL-23 in the development/progression of human malignancies. Here, we analyzed the systemic levels of these cytokines in 75 patients with different types of gastric neoplasms (carcinoma, gastrointestinal stromal tumors, neuroendocrine neoplasms, and lymphomas) and 42 healthy volunteers. We found that patients with all types of gastric neoplasms have significantly lower IL-23 levels. However, in comparison to the levels in healthy individuals, IL-17 concentrations were lower only in patients with types of gastric neoplasms other than carcinoma...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27861351/small-amounts-of-tissue-preserve-pancreatic-function-long-term-follow-up-study-of-middle-segment-preserving-pancreatectomy
#3
Zipeng Lu, Jie Yin, Jishu Wei, Cuncai Dai, Junli Wu, Wentao Gao, Qing Xu, Hao Dai, Qiang Li, Feng Guo, Jianmin Chen, Chunhua Xi, Pengfei Wu, Kai Zhang, Kuirong Jiang, Yi Miao
Middle-segment preserving pancreatectomy (MPP) is a novel procedure for treating multifocal lesions of the pancreas while preserving pancreatic function. However, long-term pancreatic function after this procedure remains unclear.The aims of this current study are to investigate short- and long-term outcomes, especially long-term pancreatic endocrine function, after MPP.From September 2011 to December 2015, 7 patients underwent MPP in our institution, and 5 cases with long-term outcomes were further analyzed in a retrospective manner...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27858880/endoscopic-ultrasound-without-tissue-acquisition-has-poor-accuracy-for-diagnosing-gastric-subepithelial-tumors
#4
Tae Won Lim, Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Su Jin Kim
Incidental gastric subepithelial tumor (SET) is frequently found during endoscopy. Although endoscopic ultrasonography (EUS) can provide useful information, its diagnostic accuracy varies. Most of the potentially malignant tumors observed on EUS are hypoechoic lesions. Therefore, we aimed to investigate the diagnostic accuracy of EUS for hypoechoic lesions located in the submucosa or proper muscle layer. We also evaluated various characteristics for potential associations with diagnostic accuracy.A retrospective review was conducted of the medical records of 99 patients who were diagnosed with gastric SET and who underwent EUS with pathologic confirmation between March 2008 and April 2015...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27853738/pedunculated-gastric-neuroendocrine-tumor-a-case-report
#5
Kenichi Takeda, Shin-Ei Kudo, Fumio Ishida
Background and study aims: Gastric neuroendocrine tumors (NETs) are rare lesions that develop from neuroendocrine cells. NETs are classified into 3 types based on the rate of mitosis and Ki-67 labeling index; the NET G1 type is synonymously referred to as carcinoid. Gastric NETs are usually discovered as submucosal tumors during upper gastrointestinal endoscopic examination. This study reports a rare case of pedunculated gastric NET. The lesion was found as a result of gastroendoscopy. The gastric lesion was a pedunculated polyp with a reddish head...
November 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27852542/factors-associated-with-elevated-serum-chromogranin-a-levels-in-patients-with-autoimmune-gastritis
#6
Çağdaş Kalkan, Fatih Karakaya, İrfan Soykan
BACKGROUND/AIMS: Chromogranin A is an important tool in the diagnosis of neuroendocrine tumors. Autoimmune gastritis is an autoimmune disorder marked by hypergastrinemia, which stimulates enterochromaffin-like cell proliferation. Chromogranin A is also elevated in autoimmune gastritis patients with a different level of increase in each patient. The goal of this study is to explore constituents that influence serum chromogranin A levels in autoimmune gastritis patients. MATERIALS AND METHODS: One hundred and eighty-eight autoimmune gastritis patients and 20 patients with type I gastric carcinoid tumors were analyzed retrospectively and compared to 110 functional dyspepsia patients in terms of factors that might affect serum chromogranin A levels...
November 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/27846844/a-rare-case-with-synchronous-gastric-gastrointestinal-stromal-tumor-pancreatic-neuroendocrine-tumor-and-uterine-leiomyoma
#7
Elena Arabadzhieva, Atanas Yonkov, Sasho Bonev, Dimitar Bulanov, Ivanka Taneva, Alexandrina Vlahova, Tihomir Dikov, Violeta Dimitrova
BACKGROUND: Although gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, they comprise less than 1% of all gastrointestinal tumors. Neuroendocrine tumors (NET) of the gastro-enteropancreatic system are also rare, representing about 2% of all gastrointestinal neoplasms. Pancreatic localization of NET is extremely uncommon-these tumors are only 1-5% of all pancreatic cancers. CASE PRESENTATION: We describe an unusual case with triple tumor localization-a gastric tumor, a formation in the pancreas, which involves the retroperitoneal space, and a uterine leiomyoma...
November 15, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27829603/a-case-of-gastric-mixed-adenoneuroendocrine-carcinoma-with-difficulty-in-diagnosis-before-endoscopic-submucosal-dissection
#8
Akihiko Sakatani, Shinichiro Shinzaki, Yoshito Hayashi, Akira Maekawa, Satoshi Hiyama, Takayuki Yakushijin, Tomohide Tatsumi, Hideki Iijima, Naoki Hiramatsu, Eiichi Morii, Tetsuo Takehara
A woman in her 60s was referred to our hospital with a superficial depressed lesion measuring 8mm in diameter on the lesser curvature of the lower gastric body. Initial biopsy of the lesion indicated a moderately differentiated adenocarcinoma. Endoscopic submucosal dissection was performed, and pathological examination revealed a tumor comprised of adenocarcinoma and neuroendocrine carcinoma with submucosal infiltration, with the final pathological diagnosis being gastric mixed adenoneuroendocrine carcinoma (MANEC)...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27821238/-gastric-neuroendocrine-tumor-with-g2-and-g3-components-report-of-a-case
#9
Y Li, H J Ti, W Xing, Y L Liu, M F Fu
No abstract text is available yet for this article.
November 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27816419/ectopic-gastric-and-intestinal-phenotypes-neuroendocrine-cell-differentiation-and-sox2-expression-correlated-with-early-tumor-progression-in-colorectal-laterally-spreading-tumors
#10
Takahito Katano, Tsutomu Mizoshita, Hironobu Tsukamoto, Hirotada Nishie, Yusuke Inagaki, Noriyuki Hayashi, Satoshi Nomura, Keiji Ozeki, Yasuyuki Okamoto, Takaya Shimura, Yoshinori Mori, Eiji Kubota, Satoshi Tanida, Hiromi Kataoka, Toshiya Kuno, Satoru Takahashi, Takashi Joh
INTRODUCTION: The significance of the ectopic gastric phenotype remains unclear in patients with colorectal laterally spreading tumors (LSTs). We investigated clinicopathologic differences among LST subtypes, aiming to identify factors indicative of malignant transformation and invasion that are linked to ectopic gastric phenotype and tumor progression. MATERIALS AND METHODS: We analyzed the morphologic characteristics of 105 colorectal LSTs resected by endoscopic submucosal dissection...
October 6, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27806846/gastric-mixed-adenoneuroendocrine-carcinoma-correlation-of-histologic-characteristics-with-prognosis
#11
Ling Nie, Mingna Li, Xiaofeng He, Anning Feng, Hongyan Wu, Xiangshan Fan
Gastric mixed adenoneuroendocrine carcinomas (MANECs) are rare, with both the exocrine and neuroendocrine components exceeding 30% volume. Several classifications for MANECs have been proposed, yet they have not been clinically evaluated. The aim of this study was to evaluate the correlation between tumor grade, histologic characteristics, and prognosis of gastric MANECs. We collected eligible 14 cases in our series and 31 cases in the literature and compared the prognostic difference among gastric MANECs with different histologic characteristics...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27756027/hand-assisted-laparoscopic-spleen-preserving-distal-pancreatectomy-combined-with-laparoscopic-distal-gastrectomy-for-the-treatment-of-pancreatic-neuroendocrine-tumor-with-early-gastric-cancer-report-of-a-case
#12
Hiroki Sugita, Hideyuki Kuroki, Takahiko Akiyama, Nobuya Daitoku, Rumi Tashima, Hiroshi Tanaka, Shinobu Honda, Masahiko Hirota
INTRODUCTION: In a distal pancreatectomy combined with a distal gastrectomy, the splenic artery and vein must be conserved. However, it is not easy in pure laparoscopic surgery. We performed a hand-assisted laparoscopic spleen-preserving distal pancreatectomy (HALS-SPDP) combined with a laparoscopic distal gastrectomy (LDG) for the treatment of a pancreatic neuroendocrine tumor (NET) with early gastric cancer. PRESENTATION OF CASE: A 67-year-old male was hospitalized with no complaint...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27744727/liver-metastases-resection-for-gastric-and-esophageal-tumors-is-there-enough-evidence-to-go-down-this-path
#13
Gonzalo Tapia Rico, Amanda R Townsend, Myron Klevansky, Timothy J Price
Surgical resection of liver metastases from colorectal and neuroendocrine tumours has become a standard of care for resectable patients with isolated hepatic disease and good performance status, leading to extended survival in a carefully selected subgroup of these patients. However, the role of hepatic surgery in gastric and oesophageal liver metastases is controversial and not clearly defined. Areas covered:a systematic electronic literature search was performed to select the most representative evidence regarding hepatectomies in liver metastases from these two tumours...
October 31, 2016: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/27710813/potential-clinical-indications-for-a-cck2-receptor-antagonist
#14
Malcolm Boyce, Katie A Lloyd, D Mark Pritchard
Gastrin controls gastric acid secretion and mucosal cell growth, especially of enterochromaffin-like cells, via gastrin/cholecystokinin-2 receptor (CCK2R) binding and downstream signalling. Studies in animal models, healthy subjects and patients with gastric neuroendocrine tumours provide compelling evidence to justify developing a CCK2R antagonist (CCK2RA) for preventing or treating the trophic effects of hypergastrinaemia or conditions expressing CCK2R, and with or without a proton pump inhibitor, for treating gastric acid-related conditions...
October 3, 2016: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/27704617/netazepide-a-gastrin-cck2-receptor-antagonist-can-eradicate-gastric-neuroendocrine-tumours-in-patients-with-autoimmune-chronic-atrophic-gastritis
#15
Malcolm Boyce, Andrew R Moore, Liv Sagatun, Bryony N Parsons, Andrea Varro, Fiona Campbell, Reidar Fossmark, Helge L Waldum, David M Pritchard
AIMS: Netazepide, a gastrin/CCK2 receptor antagonist, once daily for 12 weeks reduced the number of tumours and size of the largest one in 16 patients with autoimmune chronic atrophic gastritis (CAG), achlorhydria, hypergastrinaemia and multiple gastric neuroendocrine tumours (type 1 gastric NETs), and normalised circulating chromogranin A (CgA) produced by enterochromaffin-like cells, the source of the tumours. The aim was to assess whether longer-term netazepide treatment can eradicate type 1 gastric NETs...
October 4, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27692549/-a-pseudotumoral-lesion-revealing-meckel-s-diverticulum
#16
J Lemale, S Boudjemaa, B Parmentier, H Ducou Le Pointe, A Coulomb, L Dainese
INTRODUCTION: Meckel's diverticulum is a common malformation in children, usually asymptomatic, with complications in only 20% of cases. Exceptionally, a tumor can develop in Meckel's diverticulum in children, particularly Burkitt's lymphoma; in adults it can develop into a gastrointestinal stromal tumor, a leiomyosarcoma, or a neuroendocrine tumor such as a carcinoid tumor. The diagnosis of inflammatory pseudotumor following an insidious perforation is rare. OBSERVATION: We report the case of a 14-month-old boy who presented with fever, asthenia, food refusal, and digestive complaints such as vomiting and tender abdomen suggesting appendicitis...
September 27, 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27688729/histological-characterisation-and-prognostic-evaluation-of-62-gastric-neuroendocrine-carcinomas
#17
Yujie Deng, Xiaohui Chen, Yuhong Ye, Xi Shi, Kunshou Zhu, Liming Huang, Sheng Zhang, Mingang Ying, Xuede Lin
AIM OF THE STUDY: To determine the significance of expression of synaptophysin, chromogranin A, and Ki-67 and their association with clinicopathological parameters, and to find out the possible prognostic factors in gastric neuroendocrine carcinoma (G-NEC). MATERIAL AND METHODS: We investigated the immunohistochemical features and prognosis of 62 G-NECs, and evaluated the association among expressions of synaptophysin, chromogranin A, and Ki-67, clinicopathological variables, and outcome...
2016: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/27688667/case-of-a-tumor-comprising-gastric-cancer-and-duodenal-neuroendocrine-tumor
#18
Hiroaki Kaneko, Akio Miyake, Yasuaki Ishii, Soichiro Sue, Haruo Miwa, Tomohiko Sasaki, Toshihide Tamura, Masaaki Kondo, Shin Maeda
The present report describes a rare case of a tumor composed of early gastric cancer and a duodenal neuroendocrine tumor (NET). A 78-year-old woman underwent esophagogastroduodenoscopy at a local institution for screening of the upper gastrointestinal tract which revealed a protruded tumor through the pyloric ring from the pyloric antrum. The tumor was too large to treat at the facility; consequently, she was referred to our hospital for further management. Esophagogastroduodenoscopy with tumor biopsy of the lesion revealed the diagnosis of early gastric cancer...
September 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27682220/the-gastrin-receptor-antagonist-netazepide-yf476-in-patients-with-type-1-gastric-enterochromaffin-like-cell-neuroendocrine-tumours-review-of-long-term-treatment
#19
Liv Sagatun, Patricia Mjønes, Constantin S Jianu, Malcolm Boyce, Hege L Waldum, Reidar Fossmark
OBJECTIVE: Netazepide (YF476) is a recently developed, orally active gastrin receptor antagonist that, in short trials in patients with type 1 gastric enterochromaffin-like cell neuroendocrine tumours, has been shown to induce a significant reduction in the number and size of tumours as well as serum chromogranin A (CgA). The aim of this review is to evaluate the long-term effect and safety of netazepide. PATIENTS AND METHODS: Five patients previously treated with netazepide in an open-label trial were offered continuous treatment with netazepide 25 mg once daily...
November 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27668229/a-rare-case-of-metastatic-germ-cell-tumor-to-stomach-and-duodenum-masquerading-as-signet-ring-cell-adenocarcinoma
#20
Srijan Mazumdar, Sridhar Sundaram, Prachi Patil, Shaesta Mehta, Mukta Ramadwar
Adenocarcinomas are the most common cancers affecting stomach. However gastrointestinal stromal tumors (GIST), lymphomas and neuroendocrine tumors (NETs) can also affect the stomach. But stomach is relatively rare site of involvement by metastasis. In this case report a rare metastasis of germ cell tumor (GCT) into stomach is described which clinically and endoscopically masquerade as primary gastric cancers. But detailed clinical examination and vigilant histopathological reporting proves the origin of tumor distant from stomach and thereby change the whole approach of management...
August 2016: Annals of Translational Medicine
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