keyword
https://read.qxmd.com/read/38492784/are-age-related-neurodegenerative-diseases-caused-by-a-lack-of-the-diet-derived-compound-ergothioneine
#1
REVIEW
Barry Halliwell, Irwin Cheah
We propose that the diet-derived compound ergothioneine (ET) is an important nutrient in the human body, especially for maintenance of normal brain function, and that low body ET levels predispose humans to significantly increased risks of neurodegenerative (cognitive impairment, dementia, Parkinson's disease) and possibly other age-related diseases (including frailty, cardiovascular disease, and eye disease). Hence, restoring ET levels in the body could assist in mitigating these risks, which are rapidly increasing due to ageing populations globally...
March 14, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38474309/the-potential-of-twendee-x-%C3%A2-as-a-safe-antioxidant-treatment-for-systemic-sclerosis
#2
JOURNAL ARTICLE
Fukka You, Carole Nicco, Yoshiaki Harakawa, Toshikazu Yoshikawa, Haruhiko Inufusa
Systemic sclerosis (SSc) is an autoimmune disease characterized by systemic skin hardening, which combines Raynaud's phenomenon and other vascular disorders, skin and internal organ fibrosis, immune disorders, and a variety of other abnormalities. Symptoms vary widely among individuals, and personalized treatment is sought for each patient. Since there is no fundamental cure for SSc, it is designated as an intractable disease with patients receiving government subsidies for medical expenses in Japan. Oxidative stress (OS) has been reported to play an important role in the cause and symptoms of SSc...
March 6, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38461506/association-of-vitamin-d-levels-with-risk-of-cognitive-impairment-and-dementia-a-systematic-review-and-meta-analysis-of-prospective-studies
#3
Xiao-Xue Zhang, He-Ran Wang, Ya-Zhuo Hu, Hong-Mei Sun, Yu-Xin Feng, Jian-Jun Jia
BACKGROUND: Emerging evidence suggests the potential relationship between vitamin D deficiency and risk of cognitive impairment or dementia. To what extent the excess risk of dementia conferred by vitamin D deficiency is less clear. OBJECTIVE: We summarized the current evidence from several aspects and further quantified these associations. METHODS: We collected relevant prospective cohort studies by searching PubMed, Embase and Cochrane up to July 2023...
March 2, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38424433/proton-pump-inhibitors-and-cognitive-health-review-on-unraveling-the-dementia-connection-and-co-morbid-risks
#4
JOURNAL ARTICLE
Zuber Khan, Sidharth Mehan, Mohd Anas Saifi, Ghanshyam Das Gupta, Acharan S Narula, Reni Kalfin
Dementia, an international health issue distinguished by the impairment of daily functioning due to cognitive decline, currently affects more than 55 million people worldwide, with the majority residing in low-income and middle-income countries. Globally, dementia entails significant economic burdens in 2019, amounting to a cost of 1.3 trillion US dollars. Informal caregivers devote considerable hours to providing care for those affected. Dementia imposes a greater caregiving and disability-adjusted life-year burden on women...
February 28, 2024: Current Alzheimer Research
https://read.qxmd.com/read/38390945/rab11a-controls-cell-shape-via-c9orf72-protein-possible-relationships-to-frontotemporal-dementia-amyotrophic-lateral-sclerosis-ftdals-type-1
#5
JOURNAL ARTICLE
Shoya Fukatsu, Hinami Sashi, Remina Shirai, Norio Takagi, Hiroaki Oizumi, Masahiro Yamamoto, Katsuya Ohbuchi, Yuki Miyamoto, Junji Yamauchi
Abnormal nucleotide insertions of C9orf72, which forms a complex with Smith-Magenis syndrome chromosomal region candidate gene 8 (SMCR8) protein and WD repeat-containing protein 41 (WDR41) protein, are associated with an autosomal-dominant neurodegenerative frontotemporal dementia and/or amyotrophic lateral sclerosis type 1 (FTDALS1). The differentially expressed in normal and neoplastic cells (DENN) domain-containing C9orf72 and its complex with SMCR8 and WDR41 function as a guanine-nucleotide exchange factor for Rab GTP/GDP-binding proteins (Rab GEF, also called Rab activator)...
February 9, 2024: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://read.qxmd.com/read/38389608/long-term-use-of-proton-pump-inhibitors-unravelling-the-safety-puzzle
#6
REVIEW
Manish S Bhatnagar, Sachin Choudhari, Dattatray Pawar, Akhilesh Sharma
Globally, over 25% of the population suffers from acid-related disorders such as dyspepsia or gastroesophageal reflux disease (GERD), and around 7.6% of Indians report having GERD symptoms on a frequent enough basis to warrant a diagnosis. Over the past three decades, proton-pump inhibitors (PPIs) have been the mainstay of medical therapy for acid-peptic diseases like GERD, etc. Additionally, they are frequently prescribed for prophylactic purposes and in conjunction with non-steroidal anti-inflammatory drugs...
January 2024: Curēus
https://read.qxmd.com/read/38372958/tremendous-fidelity-of-vitamin-d3-in-age-related-neurological-disorders
#7
REVIEW
Manjari Skv, Sharon Mariam Abraham, Omalur Eshwari, Kishore Golla, Priya Jhelum, Shuvadeep Maity, Pragya Komal
Vitamin D3 (VD) is a secosteroid hormone and shows a pleiotropic effect in brain-related disorders where it regulates redox imbalance, inflammation, apoptosis, energy production, and growth factor synthesis. Vitamin D3's active metabolic form, 1,25-dihydroxy Vitamin D3 (1,25(OH)2 D3 or calcitriol), is a known regulator of several genes involved in neuroplasticity, neuroprotection, neurotropism, and neuroinflammation. Multiple studies suggest that VD deficiency can be proposed as a risk factor for the development of several age-related neurological disorders...
February 19, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38369428/reversible-dementia-and-seizures-due-to-metformin-induced-vitamin-b12-deficiency
#8
Sirine Laroussi, Nadia Bouattour, Sawsan Daoud, Khadija Sonda Moalla, Salma Sakka, Mariem Damak, Nouha Farhat, Chokri Mhiri
No abstract text is available yet for this article.
February 17, 2024: L'Encéphale
https://read.qxmd.com/read/38357313/sarcopenia-but-not-malnutrition-is-associated-with-fear-of-falling-in-older-patients-with-dementia
#9
JOURNAL ARTICLE
Saadet Koc Okudur, Lee Smith, Semen Gokce Tan, Veliye Yigitalp, Pinar Soysal
OBJECTIVE: Fear of falling (FoF) is common in patients with cognitive impairment. However, the role of sarcopenia and malnutrition, which are two important factors that cause falls, on FoF is unknown. The aim of this study was to explore the association between FoF and malnutrition and sarcopenia in older patients with dementia. METHODS: Two hundred and sixty-six dementia patients underwent comprehensive geriatric assessment. The Falls Efficacy Scale-International (FES-I) was applied to assign and classify FoF...
2024: Northern Clinics of Istanbul
https://read.qxmd.com/read/38346414/potentially-modifiable-risk-factors-for-dementia-and-mild-cognitive-impairment-an-umbrella-review-and-meta-analysis
#10
Aaron Jones, Muhammad Usman Ali, Meghan Kenny, Alexandra Mayhew, Vishal Mokashi, Henry He, Sabrina Lin, Ehsan Yavari, Karen Paik, Deejesh Subramanian, Robert Dydynsky, Komal Aryal, Rebecca H Correia, Darly Dash, Derek R Manis, Megan O'Connell, Teresa Liu-Ambrose, Vanessa Taler, Jacqueline M McMillan, David B Hogan, Susan Kirkland, Andrew P Costa, Christina Wolfson, Parminder Raina, Lauren Griffith
Introduction The prevalence of mild and major neurocognitive disorders (NCDs), also referred to as mild cognitive impairment and dementia, is rising globally. The prevention of NCDs is a major global public health interest. We sought to synthesize the literature on potentially modifiable risk factors for NCDs. Methods We conducted an umbrella review using a systematic search across multiple databases to identify relevant systematic reviews and meta-analyses. Eligible reviews examined potentially modifiable risk factors for mild or major NCDs...
February 12, 2024: Dementia and Geriatric Cognitive Disorders
https://read.qxmd.com/read/38340046/the-impact-of-sodium-glucose-co-transporter-2-inhibitors-on-dementia-and-cardiovascular-events-in-diabetic-patients-with-atrial-fibrillation
#11
JOURNAL ARTICLE
Yun-Yu Chen, Hao-Chih Chang, Yenn-Jiang Lin, Kuo-Liong Chien, Yu-Cheng Hsieh, Fa-Po Chung, Ching-Heng Lin, Gregory Y H Lip, Shih-Ann Chen
AIMS: The effectiveness of sodium-glucose co-transporter-2 inhibitors (SGLT2i) on incident dementia in patients with diabetes and atrial fibrillation (AF) remains unknown. This study aimed to investigate the association between SGLT2i and the risk of incident dementia in diabetic patients with AF, and to explore the interactions with oral anticoagulants or dipeptidyl peptidase-4 inhibitors (DPP4i). MATERIALS AND METHODS: We conducted a cohort study using Taiwan's National Health Insurance Research Database...
February 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38330435/metabolic-and-environmental-biomarkers-in-mild-cognitive-impairment-and-dementia-an-exploratory-study
#12
JOURNAL ARTICLE
Abigail C Lyon, Carol F Lippa, Arnold R Eiser
Objective: To determine the frequency with which suspected pathogenic factors, including metals and metabolites that might contribute to Alzheimer's disease (AD), may be found in patients with cognitive impairment through commonly available blood tests. Methods: A variety of serum studies, including metals, ammonia, homocysteine, vitamin B12, folate, thyroid tests, metabolic products, and inflammatory markers, were measured in two cohorts: one meeting mild cognitive impairment (MCI) criteria and the other meeting mild-to-moderate dementia (DE) criteria...
February 8, 2024: J Integr Complement Med
https://read.qxmd.com/read/38296163/impact-of-micronutrients-and-nutraceuticals-on-cognitive-function-and-performance-in-alzheimer-s-disease
#13
REVIEW
Lorenza Guarnieri, Francesca Bosco, Antonio Leo, Rita Citraro, Ernesto Palma, Giovambattista De Sarro, Vincenzo Mollace
Alzheimer's disease (AD) is a major global health problem today and is the most common form of dementia. AD is characterized by the formation of β-amyloid (Aβ) plaques and neurofibrillary clusters, leading to decreased brain acetylcholine levels in the brain. Another mechanism underlying the pathogenesis of AD is the abnormal phosphorylation of tau protein that accumulates at the level of neurofibrillary aggregates, and the areas most affected by this pathological process are usually the cholinergic neurons in cortical, subcortical, and hippocampal areas...
January 29, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38296029/the-associations-of-serum-vitamin-d-status-and-vitamin-d-supplements-use-with-all-cause-dementia-alzheimer-s-disease-and-vascular-dementia-a-uk-biobank-based-prospective-cohort-study
#14
JOURNAL ARTICLE
Li-Ju Chen, Sha Sha, Hannah Stocker, Hermann Brenner, Ben Schöttker
BACKGROUND: Prior studies on vitamin D and dementia outcomes yielded mixed results and had several important limitations. OBJECTIVES: We aimed to assess the associations of both serum vitamin D status and supplementation with all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VD) incidence. METHODS: With a prospective cohort study design, we comprehensively assessed the associations of vitamin D and multivitamin supplementation, as well as vitamin D deficiency {25-hydroxyvitamin D [25(OH)D] <30 nmol/L}, and insufficiency [25(OH)D 30 to <50 nmol/L], with the 14-year incidence of all-cause dementia, AD, and VD in 269,229 participants, aged 55 to 69, from the UK Biobank...
January 29, 2024: American Journal of Clinical Nutrition
https://read.qxmd.com/read/38259592/vitamin-b6-and-vitamin-d-deficiency-co-occurrence-in-geriatric-memory-patients
#15
JOURNAL ARTICLE
Anna G Przybelski, Barbara B Bendlin, Jana E Jones, Nicholas M Vogt, Robert J Przybelski
INTRODUCTION: Vitamin B6 and D levels are not assessed routinely in geriatric memory patients. This study examined vitamin levels to determine the potential effects on cognition. METHODS: A chart review was conducted of 203 consecutive patients over a 12-month period. Levels of vitamins B1, B6, B12, and D were obtained on the day of clinic to identify deficiencies. A mental status exam (Mini Mental State Examination [MMSE]) was also performed. RESULTS: One hundred sixty-seven patients had one or more vitamin levels obtained on the day of clinical evaluation...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/38205450/subacute-combined-degeneration-in-a-young-female-patient-after-sleeve-gastrectomy
#16
Ali Al Ani, Pir Abdul Ahad Aziz Qureshi, Vikram Rao Bollineni
The neurological symptoms of vitamin B12 deficiency are variable but primarily consist of combined spinal sclerosis, peripheral neuropathy, and dementia. Movement disorders and cerebellar ataxia are reported less frequently. We present a case of a young female patient with vitamin B12 deficiency after sleeve gastrectomy, resulting in subacute combined degeneration of the spinal cord (SACD).
December 2023: Curēus
https://read.qxmd.com/read/38198699/serum-25-hydroxyvitamin-d-vitamin-d-receptor-and-vitamin-d-binding-protein-gene-polymorphisms-and-risk-of-dementia-among-older-adults-with-prediabetes
#17
JOURNAL ARTICLE
Chun Zhou, Xiaoqin Gan, Ziliang Ye, Yanjun Zhang, Sisi Yang, Panpan He, Yuanyuan Zhang, Mengyi Liu, Qimeng Wu, Xianhui Qin
BACKGROUND: The association between vitamin D and dementia risk in those with prediabetes remains uncertain. We aimed to evaluate the association of serum 25-hydroxyvitamin D (25OHD) with incident dementia among older adults with prediabetes, and examine whether Apolipoprotein E (APOE) genotypes, vitamin D receptor (VDR) and vitamin D binding protein (VDBP) gene polymorphisms may modify this association. METHODS: 34,237 participants aged ≥60 with prediabetes (HbA1c <6...
January 10, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38196569/the-effects-of-the-interplay-between-vitamins-antibiotics-and-gut-microbiota-on-the-pathogenesis-and-progression-of-dementia-a-systematic-review-and-meta-analysis
#18
JOURNAL ARTICLE
Priyadarshi Prajjwal, Pugazhendi Inban, Valleru Pushkar Sai, Karnati Susannah Shiny, Justin Riley Lam, Jobby John, Mukhamed Sulaimanov, Yogesh Tekuru, Muhammad Wasi Ul Haq, Mohammed Dheyaa Marsool Marsool, Venu Vasanthi Sivarajan, Omniat Amir Hussin
BACKGROUND: Given that there is already evidence of a neural network that connects the brain and gut and that the gut microbiota actively modulates gut health, it is crucial to know which foods, supplements, and medications to use or avoid when treating any disease that causes dementia or cognitive impairment. Previous research has examined the relationships between vitamins, antibiotics, and gut microbiota and the correlations between these factors and dementia. The question arises of how these three factors interact together and if evidence suggests one element is more important than the others in the pathogenesis and development of dementia...
January 2024: Health Science Reports
https://read.qxmd.com/read/38154516/association-evaluations-of-oral-anticoagulants-with-dementia-risk-based-on-genomic-and-real-world-data
#19
JOURNAL ARTICLE
Junlong Ma, Heng Chen, Chan Zou, Guoping Yang
BACKGROUND: Several observational studies have suggested that oral anticoagulants (OACs) might reduce the risk of dementia in the elderly, but the evidence is inconclusive. And the consistency of this relationship across different OAC classes and dementia subtypes is still uncertain. METHODS: To comprehensively evaluate this association, we applied Mendelian randomization (MR) combined with pharmacovigilance analysis. MR was used to assess the associations between genetic proxies for three target genes of OACs (VKORC1, F2, and F10) and dementia, including Alzheimer's disease (AD) and vascular dementia (VaD)...
December 26, 2023: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38152793/impact-of-nutritional-interventions-on-alzheimer-s-disease-a-systematic-review-and-meta-analysis
#20
REVIEW
Rehana Basri, Mubarak Alruwaili, Raed AlRuwaili, Anas Mohammad Albarrak, Naif H Ali
The most prevalent type of dementia, especially in older persons, is Alzheimer's disease (AD), which has clinical signs of progressive cognitive decline and functional impairment. However, new research indicates that AD patients' dietary patterns and nutritional intake could hold the key to staving off some of the complications. Therefore, the primary aim of this investigation was to analyze various dietary patterns and the subsequent impact of the resulting nutritional intake on AD patients. Various online databases (PubMed, Scopus, Web of Science, and Google Scholar) were searched using appropriate keywords, reference searches, and citation searches...
November 2023: Curēus
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