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Small Vessels Disease

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https://www.readbyqxmd.com/read/29224304/-method-for-recording-tension-changes-of-small-pulmonary-artery-and-vein-using-the-isolated-vessel-tension-measurement-system
#1
X T Wu, M D Kuang, X Ouyang, Y Li, M M Yuan, W J Lu, J Wang, Y Q Chen
Objective: To establish a standardized method for isolated pulmonary artery and vein rings with different diameter, pressure and length, which could provide a more scientific method for in vitro study of pulmonary vessel diseases. Methods: Male SD rats were anesthetized, and the right ventricular systolic pressure were measured. Small pulmonary artery and vein rings with 200-400 μm in diameter and 2 mm in length were prepared by dissecting pulmonary arteries and veins. The pulmonary vessel rings were mounted in the organ bath by 2 stainless steel wires with diameter of 40 μm...
December 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29222944/cerebral-microbleeds-an-mri-review-of-common-and-less-common-causes
#2
REVIEW
Dimitri Renard
Cerebral microbleeds (CMB) are small foci of (acute, subacute, or chronic) blood products, best seen using MRI techniques sensitive to iron deposits (i.e. gradient-echo T2*-weighted and susceptibility-weighted imaging), frequently encountered in small vessel disease (SVD, with hypertensive vasculopathy and cerebral amyloid angiopathy as most frequent conditions) and also in other disorders. In this review, we will mainly discuss the MRI characteristics of CMB and the associated MRI abnormalities encountered in common and less common SVD and non-SVD conditions...
December 9, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29220869/non-obese-fatty-liver-disease-is-associated-with-lacunar-infarct
#3
Min-Sun Kwak, Kyung Won Kim, Hyobin Seo, Goh-Eun Chung, Jeong Yoon Yim, Donghee Kim
BACKGROUND/AIMS: Lacunar infarct, a small subcortical ischemic lesion, is a known risk factor for future cognitive impairment, dementia, and stroke. We evaluated the relationship between fatty liver disease(FLD) and lacunar infarct in a healthy general population. METHODS: Subjects who underwent brain magnetic resonance imaging(MRI) and abdominal ultrasonography(US) during health check-ups from 2007-2009 were included. FLD was diagnosed by US. Subjects with a history of cerebrovascular disease, radiological findings consistent with cerebrovascular stenosis, or cerebral small vessel disease were excluded...
December 8, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29218790/embolic-strokes-of-undetermined-source-in-young-adults-baseline-characteristics-and-long-term-outcome
#4
Nicolas Martinez-Majander, Karoliina Aarnio, Jani Pirinen, Tuomas Lumikari, Tuomo Nieminen, Mika Lehto, Juha Sinisalo, Markku Kaste, Turgut Tatlisumak, Jukka Putaala
BACKGROUND: Embolic strokes of undetermined source (ESUS) is a recent entity, not yet thoroughly investigated in young stroke patients. We compared clinical characteristics and long-term risks of vascular events and all-cause mortality between young-onset ESUS and other etiological subgroups. METHODS: Among the 1008 patients aged 15 to 49 years with first-ever ischemic stroke in Helsinki Young Stroke Registry, we identified ESUS patients, and defined primary endpoints as recurrent stroke, composite vascular events, and all-cause mortality...
December 7, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29217662/long-term-prognostic-implications-of-cerebral-microbleeds-in-chinese-patients-with-ischemic-stroke
#5
Kui Kai Lau, Yuen Kwun Wong, Kay Cheong Teo, Richard S K Chang, Man Yu Tse, Chu Peng Hoi, Chung Yan Chan, Oi Ling Chan, Ryan Hoi Kit Cheung, Edmund Ka Ming Wong, Joseph Shiu Kwong Kwan, Edward S Hui, Henry Ka Fung Mak
BACKGROUND: This study was performed to determine the clinical correlates and long-term prognostic implications of microbleed burden and location in Chinese patients with ischemic stroke. METHODS AND RESULTS: We recruited 1003 predominantly Chinese patients with ischemic stroke who received magnetic resonance imaging at the University of Hong Kong. We determined the clinical correlates of microbleeds and the long-term risks (3126 patient-years of follow-up) of recurrent ischemic stroke and intracerebral hemorrhage (ICH) by microbleed burden (0 versus 1, 2-4, and ≥5) and location, adjusting for age, sex, and vascular risk factors and stratified by antithrombotic use...
December 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29217001/long-term-safety-and-efficacy-of-platinum%C3%A2-chromium-everolimus-eluting-stents-in-coronary-artery-disease-5-year-results-from-the-platinum-trial
#6
Christopher R Kelly, Paul S Teirstein, Ian T Meredith, Bruno Farah, Christophe L Dubois, Robert L Feldman, Joseph Dens, Nobuhisa Hagiwara, Abram Rabinowitz, Didier Carrié, Vincent Pompili, Alain Bouchard, Shigeru Saito, Dominic J Allocco, Keith D Dawkins, Gregg W Stone
OBJECTIVES: The authors sought to evaluate the final 5-year safety and effectiveness of the platinum-chromium everolimus-eluting stent (PtCr-EES) in the randomized trial, as well as in 2 single-arm substudies that evaluated PtCr-EES in small vessels (diameter <2.5 mm; n = 94) and long lesions (24 to 34 mm; n = 102). BACKGROUND: In the multicenter, randomized PLATINUM (PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions), the PtCr-EES was noninferior to the cobalt-chromium everolimus-eluting stent (CoCr-EES) at 1 year in 1,530 patients undergoing percutaneous coronary intervention...
December 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29216218/stroke-subtype-classification-by-geometrical-descriptors-of-lesion-shape
#7
Bastian Cheng, Christian Knaack, Nils Daniel Forkert, Renate Schnabel, Christian Gerloff, Götz Thomalla
BACKGROUND AND PURPOSE: Inference of etiology from lesion pattern in acute magnetic resonance imaging is valuable for management and prognosis of acute stroke patients. This study aims to assess the value of three-dimensional geometrical lesion-shape descriptors for stroke-subtype classification, specifically regarding stroke of cardioembolic origin. METHODS: Stroke Etiology was classified according to ASCOD in retrospectively selected patients with acute stroke...
2017: PloS One
https://www.readbyqxmd.com/read/29210074/white-matter-degeneration-in-vascular-and-other-ageing-related-dementias
#8
REVIEW
Yoshika Hase, Karen Horsburgh, Masafumi Ihara, Raj N Kalaria
Advances in neuroimaging have enabled greater understanding of the progression of cerebral degenerative processes associated with ageing-related dementias. Leukoaraiosis or rarefied white matter (WM) originally described on computed tomography is one of the most prominent changes which occurs in older age. White matter hyperintensities (WMH) evident on magnetic resonance imaging have become commonplace to describe WM changes in relation to cognitive dysfunction, types of stroke injury, cerebral small vessel disease and neurodegenerative disorders including Alzheimer's disease...
December 6, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29208251/drug-coated-balloon-versus-drug-eluting-stent-in-primary-percutaneous-coronary-intervention-a-feasibility-study
#9
David Gobić, Vjekoslav Tomulić, Davorka Lulić, David Židan, Sandro Brusich, Tomislav Jakljević, Luka Zaputović
BACKGROUND: Drug-eluting stents (DES) represent a significant evolution in the treatment of patients with acute myocardial infarction with ST elevation. However, stent-related adverse events have led to an introduction of drug-coated balloons (DCB) applied particularly to bifurcation lesions, in-stent restenosis and small vessel disease. The aim of this study was to determine whether a DCB-only strategy has a similar safety profile and equal angiographic and clinical outcomes to DES implantation in primary percutaneous coronary intervention (pPCI)...
December 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29204377/detection-of-pulmonary-nodules-in-low-dose-computed-tomography-using-localized-active-contours-and-shape-features
#10
Zahra Nadealian, Behzad Nazari, Saeid Sadri, Mohammad Momeni
Background: Pulmonary nodules are symptoms of lung cancer. The shape and size of these nodules are used to diagnose lung cancer in computed tomography (CT) images. In the early stages, nodules are very small, and radiologist has to refer to many CT images to diagnose the disease, causing operator mistakes. Image processing algorithms are used as an aid to detect and localize nodules. Methods: In this paper, a novel lung nodules detection scheme is proposed. First, in the preprocessing stage, our algorithm segments two lung lobes to increase processing speed and accuracy...
October 2017: Journal of Medical Signals and Sensors
https://www.readbyqxmd.com/read/29201166/small-interfering-rna-against-erk1-2-attenuates-cigarette-smoke-induced-pulmonary-vascular-remodeling
#11
Muqing Yu, Xiansheng Liu, Hongxu Wu, Wang Ni, Shixin Chen, Yongjian Xu
Cigarette smoke may contribute to pulmonary vascular remodeling (PVR), a result of the proliferation of pulmonary artery smooth muscle cells (PASMCs), before pulmonary hypertension in chronic obstructive pulmonary disease (COPD). Activated extracellular signal-regulated kinases 1 and 2 (ERK1/2) are considered to be involved the process of PVR. This study investigated the potential role of ERK1/2 in the proliferation of rat PASMCs (rPASMCs) and cigarette smoke-induced PVR in rats. A small interfering RNA (siRNA) against ERK1/2 (ERK1/2-siRNA) was synthesized, and it significantly reduced the expression of ERK1/2 and cyclin E1, significantly increased the proportion of cells arrested at G0/G1 phase and significantly suppressed the proliferation of rPASMCs treated with cigarette smoke extract compared with controls (all P<0...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29200023/large-arteries-dysfunction-in-primary-antiphospholipid-syndrome
#12
Gilmar S Osmundo, Jozélio Freire Carvalho, Luiz A Bortolotto, Vilma S T Viana, Eloisa Bonfá
OBJECTIVE: The aim of this study was to assess the arterial distensibility of large vessels and changes in microvasculature in primary antiphospholipid syndrome. METHODS: Twenty-two antiphospholipid syndrome patients and 66 age-, sex-, height-, and blood pressure-matched control subjects were included in the study. Second derivative of the finger photoplethysmogram (SDPTG) has been used as a noninvasive method to evaluate the pulse wave. The b/a and d/a indices, which reflect, respectively, large-vessel and small-vessel properties, were calculated from the SDPTG waveform components...
December 1, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29198139/evaluation-of-the-coronary-flow-by-the-coronary-clearance-time-in-patients-with-cardiac-syndrome-x
#13
Erkan Yildirim, Uygar Cagdas Yuksel, Murat Celik, Baris Bugan, Mutlu Gungor, Yalcin Gokoglan, Mustafa Koklu, Suat Gormel, Salim Yasar, Cem Barcin
Objective The vessels involved in the microcirculation are too small to be visualized by conventional angiography and no tools are currently available that can directly evaluate the coronary microcirculation. This study evaluated the coronary clearance frame count (CCFC) in patients with cardiac syndrome X (CSX). Methods The retrospective study enrolled patients with angina, who had a positive nuclear imaging test and normal coronary angiography; and a control group consisting of patients who underwent an angiogram to exclude coronary artery disease...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29193569/9-4t-and-17-6t-mri-of-retinoblastoma-ex-vivo-evaluation-of-microstructural-anatomy-and-disease-extent-compared-with-histopathology
#14
Marcus C de Jong, Pim de Graaf, Petra J W Pouwels, Jan-Willem Beenakker, Robin W Jansen, Jeroen J G Geurts, Annette C Moll, Jonas A Castelijns, Paul van der Valk, Louise van der Weerd
BACKGROUND: Retinoblastoma is the most common intraocular tumor in childhood with a good prognosis in terms of mortality, but detailed information about tumor morphology and disease extent in retinoblastoma is important for treatment decision making. PURPOSE: To demonstrate ultrahigh-field MRI tumor morphology and tumor extent in retinoblastoma correlating with in and ex vivo images with histopathology. STUDY TYPE: Prospective case series...
November 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29183952/cerebellar-hematoma-location-implications-for-the-underlying-microangiopathy
#15
Marco Pasi, Sandro Marini, Andrea Morotti, Gregoire Boulouis, Li Xiong, Andreas Charidimou, Alison M Ayres, Myung Joo Lee, Alessandro Biffi, Joshua N Goldstein, Jonathan Rosand, M Edip Gurol, Steven M Greenberg, Anand Viswanathan
BACKGROUND AND PURPOSE: Spontaneous cerebellar intracerebral hemorrhage (ICH) has been reported to be mainly associated with vascular changes secondary to hypertension. However, a subgroup of cerebellar ICH seems related to vascular amyloid deposition (cerebral amyloid angiopathy). We sought to determine whether location of hematoma in the cerebellum (deep and superficial regions) was suggestive of a particular hemorrhage-prone small-vessel disease pathology (cerebral amyloid angiopathy or hypertensive vasculopathy)...
November 28, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29180960/association-of-cerebral-small-vessel-disease-burden-and-health-related-quality-of-life-after-acute-ischemic-stroke
#16
Yan Liang, Yang-Kun Chen, Min Deng, Vincent C T Mok, De-Feng Wang, Gabor S Ungvari, Chiu-Wing W Chu, Akane Kamiya, Wai-Kwong Tang
Objective: Cerebral small vessel disease (SVD) is associated with increased mortality, disability and cognitive decline, depression in stroke survivors. This study examined the association between SVD burden, defined by a combination of SVD markers, and health-related quality of life (HRQoL) in acute ischemic stroke. Methods: Patients admitted with acute ischemic stroke of any etiology were prospectively screened between January 2010 to December 2014 and enrolled in the study if they met study entry criteria...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29177162/surgical-treatment-of-small-intestinal-neuroendocrine-tumors-g1-g2
#17
REVIEW
Andreas Selberherr, Martin B Niederle, Bruno Niederle
Although the majority of neuroendocrine tumors of the small intestine (siNETs) classified as low-grade G1 or G2 show slow local growth, they are frequently diagnosed at an advanced stage of metastatic disease. The surgical treatment is curative in stages I-III or palliative in stage IV in an attempt to avoid local complications of bowel obstruction and ischemia of the small bowel by unremoved lymph node metastases. Individualized surgical procedures performed by experienced surgeons considering tumor multifocality and the primary extent of lymph node metastases along the mesenteric vessels are recommended to remove as much tumor volume as possible, while avoiding major complications intraoperatively and small bowel syndrome postoperatively...
October 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29175140/comparison-of-in-vivo-targeting-ability-between-crgd-and-collagen-targeting-peptide-conjugated-nano-carriers-for-atherosclerosis
#18
Manse Kim, Abhishek Sahu, Gi Beom Kim, Gi Hoon Nam, Wooram Um, So Jin Shin, Yong Yeon Jeong, In-San Kim, Kwangmeyung Kim, Ick Chan Kwon, Giyoong Tae
Atherosclerosis plaque is a major cause of cardiovascular diseases across the globe and a silent killer. There are no physical symptoms of the disease in its early stage and current diagnostic techniques cannot detect the small plaques effectively or safely. Plaques formed in blood vessels can cause serious clinical problems such as impaired blood flow or sudden death, regardless of their size. Thus, detecting early stage of plaques is especially more important to effectively reduce the risk of atherosclerosis...
November 21, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29173807/association-between-hemostatic-markers-serum-lipid-fractions-and-progression-of-cerebral-small-vessel-disease-a-2-year-follow-up-study
#19
Jacek Staszewski, Renata Piusińska-Macoch, Bogdan Brodacki, Ewa Skrobowska, Adam Stępień
INTRODUCTION: Little is known if hemostatic markers and serum lipid fractions can predict further radiological progression beyond vascular risk factors in cerebral small vessel disease (SVD). We investigated whether they are associated with SVD radiological progression and if they are related to different SVD clinical manifestations. METHODS: A single-center, prospective, cohort study with 2 years of radiological follow-up was performed in consecutive patients with different SVD manifestations...
November 14, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29171910/mutant-huntingtin-protein-expression-and-blood-spinal-cord-barrier-dysfunction-in-huntington-s-disease
#20
Giacomo Sciacca, Francesca Cicchetti
OBJECTIVE: The aim of the study was to assess the distribution, frequency and specific location of mutant huntingtin protein (mHTT) aggregates - the pathological hallmark of HD - within the various compartments of the spinal cord and their potential impact on the local vasculature and BSCB. METHODS: We performed a series of post-mortem immunohistochemical and immunofluorescent stainings, as well as western blot analyses, on cervical and lumbar sections of the spinal cord in patients diagnosed with HD (n=11 of all grades of disease severity) along with sex and age-matched healthy controls (n=9)...
November 24, 2017: Annals of Neurology
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