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Small Vessels Disease

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https://www.readbyqxmd.com/read/29656281/treatment-of-very-small-de-novo-coronary-artery-disease-with-2-0-mm-drug-coated-balloons-showed-1-year-clinical-outcome-comparable-with-2-0-mm-drug-eluting-stents
#1
Hui Wen Sim, Rajiv Ananthakrishna, Siew Pang Chan, Adrian F Low, Chi-Hang Lee, Mark Y Chan, Edgar L Tay, Poay Huan Loh, Koo Hui Chan, Huay Cheem Tan, Joshua P Loh
OBJECTIVE: To evaluate the 1-year clinical outcomes of patients treated with 2.0 mm drug-coated balloon (DCB) vs 2.0 mm drug-eluting stent (DES) implantation in small-caliber vessel de novo coronary artery disease (CAD). METHODS: All patients treated with 2.0 mm DCB or 2.0 mm DES for very small vessel de novo CAD from July 2014 to June 2016 were included in this study. The primary endpoint was the occurrence of target-lesion failure (TLF) and time to TLF, defined as a combination of cardiac mortality, target-vessel myocardial infarction, and target-lesion revascularization (TLR)...
April 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29656031/cerebral-small-vessel-disease-and-risk-of-incident-stroke-dementia-and-depression-and-all-cause-mortality-a-systematic-review-and-meta-analysis
#2
REVIEW
S P Rensma, T T van Sloten, L J Launer, C D A Stehouwer
MRI features of cerebral small vessel disease, i.e. white matter hyperintensities, lacunes, microbleeds, perivascular spaces, and cerebral atrophy, may be associated with clinical events, but the strength of these associations remains unclear. We conducted a systematic review and meta-analysis on the association between these features and incident ischaemic and haemorrhagic stroke, all-cause dementia and depression, and all-cause mortality. For the association with stroke, 36 studies were identified (number of individuals/events [n] = 37,987/4,087), for dementia 28 (n = 16,458/1,709), for depression nine (n = 9,538/1,746), and for mortality 28 (n = 23,031/2,558)...
April 12, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29650776/lymphatic-exosomes-promote-dendritic-cell-migration-along-guidance-cues
#3
Markus Brown, Louise A Johnson, Dario A Leone, Peter Majek, Kari Vaahtomeri, Daniel Senfter, Nora Bukosza, Helga Schachner, Gabriele Asfour, Brigitte Langer, Robert Hauschild, Katja Parapatics, Young-Kwon Hong, Keiryn L Bennett, Renate Kain, Michael Detmar, Michael Sixt, David G Jackson, Dontscho Kerjaschki
Lymphatic endothelial cells (LECs) release extracellular chemokines to guide the migration of dendritic cells. In this study, we report that LECs also release basolateral exosome-rich endothelial vesicles (EEVs) that are secreted in greater numbers in the presence of inflammatory cytokines and accumulate in the perivascular stroma of small lymphatic vessels in human chronic inflammatory diseases. Proteomic analyses of EEV fractions identified >1,700 cargo proteins and revealed a dominant motility-promoting protein signature...
April 12, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29648520/transfer-coefficients-kco-better-reflect-emphysematous-changes-than-carbon-monoxide-diffusing-capacity-dlco-in-obstructive-lung-diseases
#4
Kaoruko Shimizu, Satoshi Konno, Hironi Makita, Hirokazu Kimura, Hiroki Kimura, Masaru Suzuki, Masaharu Nishimura
The overlap between asthma and chronic obstructive pulmonary disease (COPD) has attracted the interest of pulmonary physicians; thus, measurement of carbon monoxide diffusion capacity (DLco) and/or transfer coefficients (Kco, DLco/VA) may become valuable in clinical settings. How these parameters behave in chronic obstructive lung diseases is poorly understood. We predicted that Kco might more accurately reflect emphysematous changes in the lungs, than DLco. We examined DLco and Kco in non-smokers and smokers with asthma and investigated their relationships with forced expiratory volume in 1 s (%FEV1 ) by group...
April 12, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29642694/integrated-quadruple-stress-echocardiography
#5
Eugenio Picano, Doralisa Morrone, Maria C Scali, Alda Huqi, Katia Coviello, Quirino Ciampi
Stress Echocardiography (SE) is an established diagnostic technique. For 40 years, the cornerstone of the technique has been the detection of regional wall motion abnormalities (RWMA), due to the underlying physiologically-relevant epicardial coronary artery stenosis. In the last decade, three new parameters (more objective than RWMA) have shown the potential to integrate and comple- ment RWMA: 1- B-lines, also known as ultrasound lung comets, as a marker of extra-vascular lung water, measured using lung ultrasound with the 4-site simplified scan symmetrically of the antero- lateral thorax on the third intercostal space, from mid-axillary to anterior axillary and mid- clavicular line; 2-left ventricular contractile reserve (LVCR), assessed as the peak stress/rest ratio of left ventricular force, also known as elastance (systolic arterial pressure by cuff sphygmomanome- ter/end-systolic volume from 2D echocardiography); 3- coronary flow velocity reserve (CFVR) on left anterior descending coronary artery, calculated as peak stress/rest ratio of diastolic peak flow velocity assessed using pulsed-wave Doppler...
April 11, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29627833/small-hyperintensities-in-the-area-of-the-perforating-arteries-in-patients-with-seizure
#6
Nobuyuki Izutsu, Yasunori Fujimoto, Naoaki Yamada, Ryuichiro Kajikawa, Kazuhiro Yoshimura, Munenori Nagashima, Akatsuki Wakayama, Toshiki Yoshimine
BACKGROUND/AIM: We previously observed spotty hyperintense lesions in the region of the perforating arteries on peri-ictal diffusion-weighted imaging (DWI); however, no report has formally described these findings. The aim of this study was to investigate focal intensities on peri-ictal DWI, and to evaluate the clinical significance of these lesions. METHODS: We conducted a retrospective review of 677 consecutive patients with seizure who completed peri-ictal DWI within 24 h after seizure onset...
April 6, 2018: European Neurology
https://www.readbyqxmd.com/read/29625452/inner-retinal-microvasculature-damage-correlates-with-outer-retinal-disruption-during-remission-in-beh%C3%A3-et-s-posterior-uveitis-by-optical-coherence-tomography-angiography
#7
Dan Cheng, Meixiao Shen, Xiran Zhuang, Dan Lin, Mali Dai, Sisi Chen, Fan Lu, Yuqin Wang
Purpose: To quantify the inner retinal vascular changes that occur in the superficial and deep layers in patients with Behçet's disease (BD) in remission using optical coherence tomography angiography (OCTA) and to evaluate the associations with outer retinal structure. Methods: Nineteen eyes from 19 patients with BD in remission were enrolled, including 10 eyes with less than five ocular attacks (n < 5) and nine eyes with five or more attacks (n ≥ 5). The foveal avascular zone (FAZ) and global and regional vessel density (VD) in both layers were compared between BD eyes and normal eyes...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29618553/stroke-among-young-west-africans-evidence-from-the-siren-stroke-investigative-research-and-educational-network-large-multisite-case-control-study
#8
Fred Stephen Sarfo, Bruce Ovbiagele, Mulugeta Gebregziabher, Kolawole Wahab, Rufus Akinyemi, Albert Akpalu, Onoja Akpa, Reginald Obiako, Lukman Owolabi, Carolyn Jenkins, Mayowa Owolabi
BACKGROUND AND PURPOSE: Stroke in lower and middle-income countries affects a young and productive age group. Data on factors associated with stroke in the young are sorely lacking from lower and middle-income countries. Our objective is to characterize the nature of stroke and its risk factors among young West Africans aged <50 years old. METHODS: The SIREN (Stroke Investigative Research and Educational Network) is a multicenter, case-control study involving 15 sites in Nigeria and Ghana...
April 4, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29614541/-anca-associated-vasculitis-recent-methodological-advances-for-anca-detection
#9
Elena Csernok
Anti-neutrophil cytoplasmic antibodies (ANCA) play a central role in the diagnostic and pathogenesis of patients with small vessel vasculitis, so called ANCA-associated vasculitis (AAV). ANCA in these diseases are almost always directed against proteinase 3 (PR3-ANCA) and myeloperoxidase (MPO-ANCA). Most laboratories worldwide use as standard the indirect immunofluorescence technique (IFT), on human neutrophils, to screen for ANCA, and then confirm positive IFT results with antigen specific immunoassyas for PR3- and MPO-ANCA...
April 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29608146/an-improved-method-for-collection-of-cerebrospinal-fluid-from-anesthetized-mice
#10
Nastasia K-H Lim, Visse Moestrup, Xiao Zhang, Wen-An Wang, Arne Møller, Fu-De Huang
The cerebrospinal fluid (CSF) is a valuable body fluid for analysis in neuroscience research. It is one of the fluids in closest contact with the central nervous system and thus, can be used to analyze the diseased state of the brain or spinal cord without directly accessing these tissues. However, in mice it is difficult to obtain from the cisterna magna due to its closeness to blood vessels, which often contaminate samples. The area for CSF collection in mice is also difficult to dissect to and often only small samples are obtained (maximum of 5-7 µL or less)...
March 19, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29607570/incidence-and-etiology-of-microinfarcts-in-patients-with-ischemic-stroke
#11
Jamary Oliveira-Filho, Hakan Ay, Ashkan Shoamanesh, Kwang Yeol Park, Ross Avery, Mine Sorgun, Gyeong-Moon Kim, Pedro T Cougo, Steven M Greenberg, M Edip Gurol
BACKGROUND AND PURPOSE: Cerebral microinfarcts (CMI) are associated with intracerebral hemorrhage due to small vessel disease (SVD) in studies not including an ischemic etiologic workup. We aimed to determine their incidence and potential causes in a large ischemic stroke (IS) cohort. METHODS: Consecutive patients with MRI-confirmed IS within 72 hours of onset were enrolled. Subjects had either single high-risk embolic source (cardioembolic or large vessel disease) or no embolic source...
April 1, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29605289/magnetic-resonance-imaging-markers-of-cerebral-small-vessel-disease-in-hematoma-expansion-of-intracerebral-hemorrhage
#12
Yue Suo, Weiqi Chen, Yuesong Pan, Yujing Peng, Hongyi Yan, Wei Li, Gaifen Liu, Yongjun Wang
BACKGROUND: Hematoma expansion is an independent risk factor of unfavorable outcome after intracerebral hemorrhage (ICH), which always occurs in the early phase after symptoms onset. The relationship between underlying small vessel disease (SVD) and hematoma expansion was inconsistent in patients with ICH. We aimed to investigate the relationship between magnetic resonance (MR) characteristics of SVD and hematoma expansion in patients with ICH within 72 hours after symptoms onset. METHODS: Data were derived from a cohort of biological sample collection from April 2014 to April 2016...
March 28, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29604087/uteroplacental-insufficiency-temporally-exacerbates-salt-induced-hypertension-associated-with-a-reduced-natriuretic-response-in-male-rat-offspring
#13
Linda A Gallo, Sarah L Walton, Marc Q Mazzuca, Marianne Tare, Helena C Parkington, Mary E Wlodek, Karen M Moritz
Intrauterine growth restriction increases the risk of developing chronic diseases in adulthood. Lifestyle factors, such as poor dietary choices, may elevate this risk. We determined whether being born small increases the sensitivity to a dietary salt challenge, in the context of hypertension, kidney disease and arterial stiffness. Bilateral uterine vessel ligation or sham surgery (offspring termed Restricted and Control, respectively) was performed on 18-day pregnant WKY rats. Male offspring were allocated to receive a diet high in salt (8% sodium chloride) or remain on standard rat chow (0...
March 31, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29602232/long-term-survival-in-locally-advanced-non-small-cell-lung-cancer-invading-the-great-vessels-and-heart
#14
Byungjoon Park, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi, Jae Il Zo, Young Mog Shim, Jhingook Kim
BACKGROUND: The aim of this study was to analyze the surgical outcomes of locally advanced lung cancer invading the great vessels or heart, according to the extension of cancer invasion. METHODS: From 1995 to 2015, 59 patients who were surgically treated and pathologically diagnosed with T4N0-1 non-small cell lung cancer with invasion to the great vessels or heart were enrolled. Surgical outcomes were compared between patient groups with and without intrapericardial invasion...
March 30, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29599314/correlation-of-expression-of-tenascin-c-and-blood-vessel-density-in-non-small-cell-lung-cancers
#15
Adam Rzechonek, Jedrzej Grzegrzolka, Piotr Blasiak, Maciej Ornat, Aleksandra Piotrowska, Aleksandra Nowak, Piotr Dziegiel
BACKGROUND/AIM: Non-small cell lung cancers are cancer diseases that rank second in terms of incidence and first in terms of mortality, worldwide. Stromal cells of these cancers express tenascin C (TNC) - hexameric glycoprotein, which is also expressed during foetal life. TNC is also observed in stromal cells of most human cancers. In some cancers, TNC was shown to influence proliferation and migration of cancer cells and angiogenesis. The aim of this work was to analyze the correlation of expression of TNC with the markers of vascular endothelial cells, CD31 and CD34, and clinicopathological data in NSCLC...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29599186/in-depth-hemodynamic-phenotyping-of-pulmonary-hypertension-due-to-left-heart-disease
#16
Christian Gerges, Mario Gerges, Pierre Fesler, Anna Maria Pistritto, Nicholas P Konowitz, Johannes Jakowitwsch, David S Celermajer, Irene M Lang
The commonest cause of pulmonary hypertension (PH) is left heart disease (LHD). The current classification system for definitions of PH-LHD is under review. We therefore performed prospective in-depth invasive hemodynamic phenotyping in order to assess the site of increased pulmonary vascular resistance (PVR) in PH-LHD subsets.Based on pulmonary artery occlusion waveforms yielding an estimate of the effective capillary pressure (P c' ), we partitioned PVR in larger arterial (R up , upstream resistance) and small arterial plus venous components (R ds , downstream resistance)...
March 29, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29595639/an-overlooked-cause-in-a-patient-with-recurrent-ischemic-stroke-a-case-report
#17
Xunzhe Yang, Mingsheng Liu, Yicheng Zhu, Xiaobo Zhang, Shan Gao, Jun Ni
RATIONALE: The majority of ischemic strokes are due to cardioembolism, large vessel atherothromboembolism, small vessel occlusive disease, or other unusual mechanisms. In most clinical settings, many strokes without a well-defined etiology requires a thorough diagnostic evaluation, otherwise the underlying cause might be easily overlooked. Here we report on the rare cause of a patient with recurrent stroke. PATIENT CONCERNS: A 50-year-old female patient had a 4-year history of recurrent acute onset of neurological deficits...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29594711/validation-and-optimization-of-bianca-for-the-segmentation-of-extensive-white-matter-hyperintensities
#18
Yifeng Ling, Eric Jouvent, Louis Cousyn, Hugues Chabriat, François De Guio
White matter hyperintensities (WMH) are a hallmark of small vessel diseases (SVD). Yet, no automated segmentation method is readily and widely used, especially in patients with extensive WMH where lesions are close to the cerebral cortex. BIANCA (Brain Intensity AbNormality Classification Algorithm) is a new fully automated, supervised method for WMH segmentation. In this study, we optimized and compared BIANCA against a reference method with manual editing in a cohort of patients with extensive WMH. This was achieved in two datasets: a clinical protocol with 90 patients having 2-dimensional FLAIR and an advanced protocol with 66 patients having 3-dimensional FLAIR...
March 29, 2018: Neuroinformatics
https://www.readbyqxmd.com/read/29593551/retinal-vessel-diameters-and-physical-activity-in-patients-with-mild-to-moderate-rheumatic-disease-without-cardiovascular-comorbidities
#19
Arne Deiseroth, Thimo Marcin, Colette Berger, Denis Infanger, Juliane Schäfer, Bettina Bannert, Arno Schmidt-Trucksäss, Reinhard E Voll, Diego Kyburz, Henner Hanssen
Objectives: Low-grade systemic inflammation is responsible for atherosclerotic lesions in patients with rheumatic diseases. Vascular dysfunction is a precursor of atherosclerosis and can be improved by physical activity (PA). Our aim was to asses micro- and macrovascular function as well as PA and cardiorespiratory fitness (CRF) in patients with rheumatic diseases in the absence of cardiovascular (CV) comorbidities compared to controls. Methods: Fifty-one patients without CV comorbidities were compared to 35 controls...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29581240/intracranial-arterial-dolichoectasia-and-stenosis-risk-factors-and-relation-to-cerebral-small-vessel-disease
#20
Fei-Fei Zhai, Shuang Yan, Ming-Li Li, Fei Han, Quan Wang, Li-Xin Zhou, Jun Ni, Ming Yao, Shu-Yang Zhang, Li-Ying Cui, Zheng-Yu Jin, Yi-Cheng Zhu
BACKGROUND AND PURPOSE: Intracranial arterial dolichoectasia (IADE) is a poorly understood arteriopathy compared with intracranial atherosclerotic stenosis (ICAS). We aimed to investigate the risk factors of IADE and ICAS and their relationship with neuroimaging markers of cerebral small vessel disease in a population-based study. METHODS: This study comprised 1237 participants (aged 57.2±9.4 years, 37.6% men) who underwent brain magnetic resonance imaging and magnetic resonance angiography...
March 26, 2018: Stroke; a Journal of Cerebral Circulation
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