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https://www.readbyqxmd.com/read/27925499/non-adherence-to-psychotropic-medication-among-adolescents-a-systematic-review-of-the-literature
#1
Alexander Häge, Lisa Weymann, Lucia Bliznak, Viktoria Märker, Konstantin Mechler, Ralf W Dittmann
INTRODUCTION: Whether patients take their medication as prescribed is of increasing importance in adolescent psychiatry since both the number of efficacious pharmaceutical treatments and the rate of prescriptions of psychotropic compounds are on the rise. Previous research showed high rates of medication nonadherence among both adolescents with medical disorders and adult patients with psychiatric disorders. METHODS: The present review was performed according to PRISMA guidelines and evaluates existing scientific literature concerning adherence to psychotropic medication among adolescents...
December 7, 2016: Zeitschrift Für Kinder- und Jugendpsychiatrie und Psychotherapie
https://www.readbyqxmd.com/read/27918948/adult-autism-subthreshold-spectrum-adas-spectrum-validation-of-a-questionnaire-investigating-subthreshold-autism-spectrum
#2
L Dell'Osso, C Gesi, E Massimetti, I M Cremone, M Barbuti, G Maccariello, I Moroni, S Barlati, G Castellini, M Luciano, L Bossini, M Rocchetti, M Signorelli, E Aguglia, A Fagiolini, P Politi, V Ricca, A Vita, C Carmassi, M Maj
AIM: Increasing literature has shown the usefulness of a dimensional approach to autism. The present study aimed to determine the psychometric properties of the Adult Autism Subthreshold Spectrum (AdAS Spectrum), a new questionnaire specifically tailored to assess subthreshold forms of autism spectrum disorder (ASD) in adulthood. METHODS: 102 adults endorsing at least one DSM-5 symptom criterion for ASD (ASDc), 143 adults diagnosed with a feeding and eating disorder (FED), and 160 subjects with no mental disorders (CTL), were recruited from 7 Italian University Departments of Psychiatry and administered the following: SCID-5, Autism-Spectrum Quotient (AQ), Ritvo Autism and Asperger Diagnostic Scale 14-item version (RAADS-14), and AdAS Spectrum...
November 9, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27917218/can-we-predict-agitation-in-patients-with-suicide-attempts-in-the-emergency-department
#3
Ayhan Akoz, Sultan Tuna Akgol Gur, Elif Oral, Ummu Zeynep Avsar, Mucahit Emet
BACKGROUND: The agitation in patients presenting to the emergency department (ED) after suicide attempts is common and an important problem. OBJECTIVE: To establish whether we can predict agitated patients among suicide attempt patients in ED. METHODS: This is a cross-sectional observational study of adult suicide attempt events in ED. Information was collected prospectively on a specially designed data-collection form. Patients aged 16 years old and above who presented to the ED for care due to suicide attempts were included in the study...
September 2016: African Health Sciences
https://www.readbyqxmd.com/read/27913990/sirukumab-a-potential-treatment-for-mood-disorders
#4
REVIEW
Aileen J Zhou, Yena Lee, Giacomo Salvadore, Benjamin Hsu, Trehani M Fonseka, Sidney H Kennedy, Roger S McIntyre
Convergent evidence indicates that abnormalities in the innate immune system may be pertinent to the pathogenesis, phenomenology, and possible treatment of several mental disorders. In keeping with this view, the targeting of interleukin-6 with the human monoclonal antibody sirukumab may represent a possible treatment and disease modification approach, for adults with brain-based disorders (e.g., major depressive disorder). A PubMed/Medline database search was performed using the following search terms: sirukumab; anti-IL-6; IL-6; major depressive disorder; inflammation...
December 2, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27907025/measuring-social-motivation-using-signal-detection-and-reward-responsiveness
#5
Coralie Chevallier, Natasha Tonge, Lou Safra, David Kahn, Gregor Kohls, Judith Miller, Robert T Schultz
BACKGROUND: Recent trends in psychiatry have emphasized the need for a shift from categorical to dimensional approaches. Of critical importance to this transformation is the availability of tools to objectively quantify behaviors dimensionally. The present study focuses on social motivation, a dimension of behavior that is central to a range of psychiatric conditions but for which a particularly small number of assays currently exist. METHODS: In Study 1 (N = 48), healthy adults completed a monetary reward task and a social reward task, followed by completion of the Chapman Physical and Social Anhedonia Scales...
2016: PloS One
https://www.readbyqxmd.com/read/27899267/tracking-health-care-service-use-and-the-experiences-of-adults-with-autism-spectrum-disorder-without-intellectual-disability-a-longitudinal-study-of-service-rates-barriers-and-satisfaction
#6
Vanessa Vogan, Johanna K Lake, Ami Tint, Jonathan A Weiss, Yona Lunsky
BACKGROUND: Adults with Autism Spectrum Disorder (ASD) encounter many difficulties finding and accessing health care services. Despite this, few studies have considered the health service use patterns of adults with ASD without intellectual disability (ID). OBJECTIVES: The current study examines a diverse range of medical and mental health services and supports, as well as adults' personal experiences accessing and using these services, barriers to service use, and reported unmet service needs...
November 22, 2016: Disability and Health Journal
https://www.readbyqxmd.com/read/27895323/elevated-cyp2c19-expression-is-associated-with-depressive-symptoms-and-hippocampal-homeostasis-impairment
#7
M M Jukić, N Opel, J Ström, T Carrillo-Roa, S Miksys, M Novalen, A Renblom, S C Sim, E M Peñas-Lledó, P Courtet, A Llerena, B T Baune, D J de Quervain, A Papassotiropoulos, R F Tyndale, E B Binder, U Dannlowski, M Ingelman-Sundberg
The polymorphic CYP2C19 enzyme metabolizes psychoactive compounds and is expressed in the adult liver and fetal brain. Previously, we demonstrated that the absence of CYP2C19 is associated with lower levels of depressive symptoms in 1472 Swedes. Conversely, transgenic mice carrying the human CYP2C19 gene (2C19TG) have shown an anxious phenotype and decrease in hippocampal volume and adult neurogenesis. The aims of this study were to: (1) examine whether the 2C19TG findings could be translated to humans, (2) evaluate the usefulness of the 2C19TG strain as a tool for preclinical screening of new antidepressants and (3) provide an insight into the molecular underpinnings of the 2C19TG phenotype...
November 29, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27889282/neuromodulation-treatments-for-geriatric-mood-and-cognitive-disorders
#8
REVIEW
William M McDonald
There is increasing evidence for the efficacy of neuromodulation in the treatment of resistant mood disorders and emerging data supporting the use of neuromodulation in cognitive disorders. A significant minority of depressed elders do not respond to pharmacotherapy and/or psychotherapy. This has led clinicians to recommend the increasing use of electroconvulsive therapy (ECT) in the treatment of medication-resistant or life-threatening geriatric depression. Multiple studies have supported the safety and efficacy of ECT in the elderly, yet ECT is associated with side effects including cardiovascular and cognitive side effects...
December 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27871720/-guidelines-for-the-prescription-of-mood-stabilizers-for-adolescents-a-literature-review
#9
G Munch, N Godart
INTRODUCTION: Adolescence is a unique phase of the human developmental process. In adolescents, psychotropic medications may have different efficacy and tolerance profiles compared to those at other stages of the lifespan. Mood stabilizers are a complex pharmacological category including lithium, some anticonvulsants, and some second generation antipsychotics. Focusing on this class of pharmacological agents, we aim to answer the following questions: in which indications and according to which modalities should mood stabilizers be prescribed during adolescence? METHODS: Information was sought from the websites of the French Haute Autorité de santé (HAS) and Agence nationale de sécurité du médicament et des produits de santé (ANSM), the American Food and Drug Administration (FDA) and the British National Institute for Health and Clinical Excellence (NICE)...
November 18, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27857045/long-term-pharmacotherapy-by-methylfenidate-or-atomoxetine-dat-1-10-10-adhd-children-in-correlation-with-results-of-the-imaging-methods
#10
(no author information available yet)
OBJECTIVES: ADHD is one of the most significant diagnostic units in child and adolescent psychiatry. The occurrence in children is 5-6% and 50-80% continued to adult age. The presence of individual genes (polymorphism) on particular symptoms and processes in ADHD are not known. It is estimated that ADHD symptoms are up to 80% to genetic. The higher density of resultant DAT 1 protein was observed in ADHD patients in comparison with controls. The question was if DAT 1 10/10 predicted bad prognoses in long term therapy...
September 18, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/27844247/a-profile-on-emergency-department-utilization-in-adolescents-and-young-adults-with-autism-spectrum-disorders
#11
Guodong Liu, Amanda M Pearl, Lan Kong, Douglas L Leslie, Michael J Murray
There has been an increase in utilization of the Emergency Department (ED) in individuals with autism spectrum disorder (ASD) which may reflect a deficit of services (Green et al., Journal of the American Academy of Child and Adolescent Psychiatry 40(3):325-332, 2001; Gurney et al., Archives of Pediatric and Adolescent Medicine 160:825-830, 2006; Leichtman et al., American Journal of Orthopsyhciatry 72(2):227-235, 2001). The current study examined the rates of ED utilization between 2005 and 2013 in ASD youth 12- to 21-years-old...
November 14, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27843152/additive-effects-of-oxytocin-receptor-gene-polymorphisms-on-reward-circuitry-in-youth-with-autism
#12
L M Hernandez, K Krasileva, S A Green, L E Sherman, C Ponting, R McCarron, J K Lowe, D H Geschwind, S Y Bookheimer, M Dapretto
Several common alleles in the oxytocin receptor gene (OXTR) are associated with altered brain function in reward circuitry in neurotypical adults and may increase risk for autism spectrum disorders (ASD). Yet, it is currently unknown how variation in the OXTR relates to brain functioning in individuals with ASD, and, critically, whether neural endophenotypes vary as a function of aggregate genetic risk. Here, for we believe the first time, we use a multi-locus approach to examine how genetic variation across several OXTR single-nucleotide polymorphisms (SNPs) affect functional connectivity of the brain's reward network...
November 15, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27843149/jnk1-controls-adult-hippocampal-neurogenesis-and-imposes-cell-autonomous-control-of-anxiety-behaviour-from-the-neurogenic-niche
#13
H Mohammad, F Marchisella, S Ortega-Martinez, P Hollos, K Eerola, E Komulainen, N Kulesskaya, E Freemantle, V Fagerholm, E Savontous, H Rauvala, B D Peterson, H van Praag, E T Coffey
Promoting adult hippocampal neurogenesis is expected to induce neuroplastic changes that improve mood and alleviate anxiety. However, the underlying mechanisms remain largely unknown and the hypothesis itself is controversial. Here we show that mice lacking Jnk1, or c-Jun N-terminal kinase (JNK) inhibitor-treated mice, display increased neurogenesis in adult hippocampus characterized by enhanced cell proliferation and survival, and increased maturation in the ventral region. Correspondingly, anxiety behaviour is reduced in a battery of tests, except when neurogenesis is prevented by AraC treatment...
November 15, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27837574/there-is-no-safe-threshold-for-lead-exposure-%C3%AE-literature-review
#14
Th Vorvolakos, S Arseniou, M Samakouri
: Lead was one of the most dangerous environmental toxic substances for a long time in western countries, and this is still the case for many places on earth today. Its neurotoxic potential is highly significant but its secure blood level concentration remains unknown. The aim of this study was to approach the above issue from the perspective of social psychiatry. A systematic search was made of Dialog and Datastar interfaces for data regarding the neuropsychiatric complications of direct or chronic exposure to lead, and a review of the relevant literature was conducted using the databases Medline, Embase, CAB Global Health and Cochrane...
July 2016: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/27833238/screening-for-depression-among-community-dwelling-elders-usefulness-of-the-center-for-epidemiologic-studies-depression-scale
#15
Sebind Kumar, Anisha Nakulan, Sumesh Purushothaman Thoppil, Rejani Parameshwaran Parassery, Shaji Sivaraman Kunnukattil
CONTEXT: Though common, depressive disorders often remain undetected in late life. AIM: To examine the usefulness of Center for Epidemiologic Studies Depression (CES-D) for identifying depression among older people. SETTINGS AND DESIGN: Community resident older people (aged 65 years or more), were evaluated by clinicians trained in psychiatry, as part of a cross-sectional study of late-life depression. Assessments were done in the community...
September 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/27826750/an-international-position-paper-on-mother-infant-perinatal-mental-health-with-guidelines-for-clinical-practice
#16
Ian Brockington, Ruth Butterworth, Nine Glangeaud-Freudenthal
The purpose of this paper is to set out informal, provisional and comprehensive but concise guidelines for mother-infant (perinatal) mental health (psychiatry), as an area of specialisation. It is informal in the sense that the authors are clinicians and researchers from many different nations, who share a common goal and vision, speaking on their own behalf and not with the backing of any authority or society. It is provisional in the expectation that it can be improved by criticism and new research findings...
November 8, 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27825017/a-pharmacological-overview-of-lamotrigine-for-the-treatment-of-epilepsy
#17
Venkata Ramesh Yasam, Satya Lavanya Jakki, V Senthil, M Eswaramoorthy, S Shanmuganathan, K Arjunan, M J Nanjan
Epilepsy is one of the most common neurological disorders, affecting about 2% of the population worldwide. Lamotrigine (LTG) is a second generation anti-epileptic drug (AED) with broad spectrum of activity, a favourable side-effect profile, simpler dosing than earlier drugs and efficacious in diverse epilepsy syndromes. Areas covered: The present review focuses on pharmacodynamics, pharmacokinetics, clinical efficacy, safety and tolerability of LTG and its effect on cognition, psychiatry, quality of life, women and pregnancy along with effect of enzyme inducing and enzyme inhibiting drugs over LTG and their effect on serum level fluctuations by collecting data from various studies over the years until 2016...
December 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27819619/-nicht-von-schlechten-eltern-nische-a-family-orientated-collaborative-care-approach-to-support-children-in-families-with-mentally-ill-parents
#18
Pascal Wabnitz, Klaus-Thomas Kronmüller, Erwin Wieskus-Friedemann, Sabine Kliem, Johannes Hoppmann, Monika Burek, Michael Löhr, Ulrich Kemper, André Nienaber
"Nicht von schlechten Eltern - NischE": A Family Orientated Collaborative Care Approach to Support Children in Families with Mentally Ill Parents The present work describes the setting- and multi-professional offer "NischE" in Gütersloh, a systemic approach for the care of children and their mentally ill parents. Children of mentally ill parents are a special risk group for developing their own mental illness. The aim of the collaborative care model between child and adolescent psychiatry, youth services and adult psychiatry is to enable affected families in terms of family-focused practice a low threshold access to different services...
November 2016: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/27811466/symptoms-of-anxiety-in-older-adults-with-depression-dementia-or-psychosis-a-principal-component-analysis-of-the-geriatric-anxiety-inventory
#19
Anette Bakkane Bendixen, Cecilie Bhandari Hartberg, Geir Selbæk, Knut Engedal
AIMS: The primary aim of this study was to examine anxiety symptoms as measured by the Geriatric Anxiety Inventory (GAI) in older patients with depression, dementia, or psychotic disorders. The secondary aim was to conduct a principal component analysis (PCA) of the GAI and to examine whether its subscales differ between the 3 disorders. METHODS: We included data from 428 patients who were admitted to a department of geriatric psychiatry and examined according to a standardized protocol...
2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27800284/the-standard-for-clinicians-interview-in-psychiatry-scip-a-clinician-administered-tool-with-categorical-dimensional-and-numeric-output-conceptual-development-design-and-description-of-the-scip
#20
REVIEW
Ahmed Aboraya, Henry Nasrallah, Srinivas Muvvala, Ahmed El-Missiry, Hader Mansour, Cheryl Hill, Daniel Elswick, Elizabeth C Price
Existing standardized diagnostic interviews (SDIs) were designed for researchers and produce mainly categorical diagnoses. There is an urgent need for a clinician-administered tool that produces dimensional measures, in addition to categorical diagnoses. The Standard for Clinicians' Interview in Psychiatry (SCIP) is a method of assessment of psychopathology for adults. It is designed to be administered by clinicians and includes the SCIP manual and the SCIP interview. Clinicians use the SCIP questions and rate the responses according to the SCIP manual rules...
May 2016: Innovations in Clinical Neuroscience
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