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https://www.readbyqxmd.com/read/29131288/mechanisms-of-cardioembolic-stroke-revisited-atrial-cardiopathy
#1
Justyna Mączyńska, Iwona Kurkowska-Jastrzębska, Rafał Dąbrowski
There has been only moderate progress in our understanding of potential relation between atrial arrhythmia and stroke over years. Current approach is still based on a hypothesis that atrial contractile dysfunction due to fibrillation causes blood stasis, which accompanied by other factors acting together as Virchow's triad produces thrombus and embolism to the brain. In this review we would like to discuss a relatively new concept of atrial cardiopathy. It assumes that risk of thromboembolism is increased regardless of atrial rhythm, being largely driven by atrial tissue abnormalities, such as fibrosis, endothelial and myocytes dysfunction and atrial dilatation...
November 13, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29126909/-demographic-analysis-of-a-congenital-heart-disease-clinic-of-the-mexican-institute-of-social-security-with-special-interest-in-the-adult
#2
Horacio Márquez-González, Lucelli Yáñez-Gutiérrez, Jimena Lucely Rivera-May, Diana López-Gallegos, Eduardo Almeida-Gutiérrez
INTRODUCTION: Congenital heart disease (CHD) has an incidence of 8-10 cases per 1000 live births. In Mexico, there are 18,000-20,000 new cases per year. Most tertiary care centers for CHD attend only pediatric population; the Mexican Institute of Social Security (IMSS) has a clinic that attends pediatric and adult population. OBJECTIVE: To analyze the demographic aspects of the CHD clinic of IMSS. METHODS: From 2011 to 2016 a cross-sectional study of the CC clinic of a third level hospital of the IMSS, including all patients with confirmed structural heart disease of recent diagnosis was carried out...
November 7, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/29125030/exploring-the-effect-of-d61g-mutation-on-shp2-cause-gain-of-function-activity-by-a-molecular-dynamics-study
#3
Hong-Lian Li, Ying Ma, Chang-Jie Zheng, Wen-Yan Jin, Wen-Shan Liu, Run-Ling Wang
Noonan syndrome (NS) is a common autosomal dominant congenital disorder which could cause the congenital cardiopathy and cancer predisposition. Previous studies reported that the knock-in mouse models of the mutant D61G of SHP2 exhibited the major features of NS, which demonstrated that the mutation D61G of SHP2 could cause NS. To explore the effect of D61G mutation on SHP2 and explain the high activity of the mutant, molecular dynamic (MD) simulations were performed on wild type (WT) of SHP2 and the mutated SHP2-D61G, respectively...
November 10, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29122798/impact-of-prenatal-diagnosis-on-survival-of-newborns-with-four-congenital-heart-defects-a-prospective-population-based-cohort-study-in-france-the-epicard-study
#4
Babak Khoshnood, Nathalie Lelong, Lucile Houyel, Damien Bonnet, Morgane Ballon, Jean-Marie Jouannic, François Goffinet
OBJECTIVES: (1) Assess the population-level probability of prenatal diagnosis and termination of pregnancy for fetal anomaly for four major congenital heart defects; (2) Examine, using population-based data, the relation between timing of (prenatal vs postnatal) diagnosis and risk of infant (ie, < 1 year) mortality for four major congenital heart defects (CHDs). DESIGN: Population-based cohort (the EPIdémiologie des CARDiopathies congénitales) study. SETTING: Greater Paris area (Paris and its surrounding suburbs)...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29062350/secular-trend-of-the-leading-causes-of-death-in-china-from-2003-to-2013
#5
Yongcheng Ren, Ming Zhang, Xinping Luo, Jingzhi Zhao, Lei Yin, Chao Pang, Tianping Feng, Shu Wang, Bingyuan Wang, Hongyan Zhang, Xiangyu Yang, Dongsheng Hu
BACKGROUND: To analyze the epidemiological characteristics and secular trends of the leading causes of death in China. METHODS: Data on the leading causes of death was collected from the Statistical Yearbook of China. Data for 11 years, from 2003 to 2013, was analyzed by regression analysis and chi-square test. RESULTS: The top 3 causes of death from 2009 to 2013 were cancer, cerebrovascular disease, and cardiopathy, with the role of cardiopathy increasing over time (P<0...
June 2017: African Health Sciences
https://www.readbyqxmd.com/read/29062232/mitochondrial-multiorgan-disorder-syndrome-score-generated-from-definite-mitochondrial-disorders
#6
Josef Finsterer, Sinda Zarrouk-Mahjoub
OBJECTIVES: Mitochondrial disorders (MIDs) frequently present as mitochondrial multiorgan disorder syndrome (MIMODS) at onset or evolve into MIMODS during the course. This study aimed to find which organs and/or tissues are most frequently affected by MIMODS, which are the most frequent abnormalities within an affected organ, whether there are typical MIMODS patterns, and to generate an MIMODS score to assess the diagnostic probability for an MID. METHODS: This is a retrospective evaluation of clinical, biochemical, and genetic investigations of adult patients with definite MIDs...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29062197/n-terminal-pro-brain-natriuretic-peptides-in-dogs-and-cats-a-technical-and-clinical-review
#7
REVIEW
Gabriela Vieira de Lima, Felipp da Silveira Ferreira
Biomarkers are quantitative indicators of biological processes performed by an organ or system. In recent years, natriuretic peptides (NPs) have emerged as important tools in the diagnosis and therapeutic monitoring of heart diseases. Research has shown that serum and plasma levels of N-terminal pro brain NP (NT-proBNP) in dogs and cats are the only biomarkers that afford to diagnose and monitor congestive processes and, indirectly, the myocardial function of small animals. The present review discusses the peer-reviewed specialized literature about NT-proBNP and presents and compares the potential clinical applications of this NP in veterinary medicine of small animals, considering diagnosis, follow-up, and prognosis of myocardial or systemic diseases...
September 2017: Veterinary World
https://www.readbyqxmd.com/read/28959873/prognostic-factors-in-chronic-subdural-hematoma-results-from-a-monocentric-consecutive-surgical-series-of-605-patients
#8
Susanna Bacigaluppi, Fedra Guastalli, Nicola L Bragazzi, Alberto Balestrino, Paolo Bruzzi, Gianluigi Zona
BACKGROUND: The study of age-related diseases like chronic subdural hematoma (CSDH) is of high interest, considered the general ageing of the population. This investigation aimed to identify the main clinical characteristics of CSDH patients, to evaluate the impact of the disease on quality of life, its treatment and co-morbidities/complications and to compare our data with other surgical series published over the past 5 years. METHODS: A retrospective cohort study including all consecutive patients operated for CSDH between January 1st 2006 and December 31st 2013 at the Unit of Neurosurgery of our hospital was carried out...
September 28, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28926334/family-phenotypic-heterogeneity-caused-by-mitochondrial-dna-mutation-a3243g
#9
Daniela Alves, Maria Eufémia Calmeiro, Carmo Macário, Rosa Silva
Maternally inherited diabetes and deafness is a rare form of diabetes caused by a mitochondrial DNA mutation. The index case is a 55-year-old woman who was admitted with hypertrophic cardiomyopathy. She had a history of diabetes mellitus and hearing loss. The patient's mother, two brothers and two sisters also had a history of diabetes and hearing loss. This pattern suggests a maternally inherited disorder. All siblings carried the A3243G mitochondrial DNA mutation. The identification of people with monogenic forms of diabetes mellitus is a diagnostic challenge...
August 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28913555/outcome-of-intrahepatic-portosystemic-shunt-diagnosed-prenatally
#10
Bérengère Francois, Fréderic Gottrand, Alain Lachaux, Corinne Boyer, Bernard Benoit, Stéphanie De Smet
We analyzed the characteristics of the population with congenital portosystemic shunt diagnosed during the antenatal period and the organization of their perinatal care. This multicentric retrospective study included all the patients with a prenatal diagnosis of congenital portosystemic shunt. Between 1999 and 2015, 12 patients were included. Prenatal diagnosis was done at a median 26.5 weeks of gestation (21-34). All the patients presented intrahepatic CPSS, three of them had associated congenital cardiopathy, and one a Bannayan-Zonana syndrome...
December 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28871828/eating-behaviors-and-emotional-distress-are-predicted-by-treatment-and-adverse-outcome-in-patients-with-type-2-diabetes
#11
Arnulfo González-Cantú, Leonor Mireles-Zavala, Anabel Rodríguez-Romo, Elizabeth Olavide-Aguilar, Natalia Eloisa De la Garza-Hernández, Maria Elena Romero-Ibarguengoitia
Depression and anxiety are hightly prevalent among patients with Type 2 Diabetes (T2D), however not commonly related to outcomes, treatment and comorbidities. Eating behaviors could also have an implication. To evaluate the relation between mood and eating behaviors with demographic, physical, treatment, biochemical profiles and chronic comorbidities in T2D we conducted this exploratory cross sectional study in a population from Mexico. Hospital Anxiety and Depression Scale and the Three Factor Eating Questionnaire Revised 21 (TFEQ-R21) were correlated with age, gender, blood pressure, treatment and comorbidities (nephropathy, neuropathy, retinopathy and cardiopathy)...
September 5, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28856160/mortality-and-cardiovascular-complications-in-older-complex-chronic-patients-with-type-2-diabetes
#12
J L Clua-Espuny, M A González-Henares, M L L Queralt-Tomas, W Campo-Tamayo, E Muria-Subirats, A Panisello-Tafalla, J Lucas-Noll
AIMS/INTRODUCTION: Determining the prevalence of diabetes and its cardiovascular complications and all-cause mortality in older chronic complex patients. MATERIALS AND METHODS: We carried out a multicenter retrospective study and included a randomized sample of 932 CCP people. We assessed the prevalence of diabetes according to World Health Organization criteria. Data included demographics and functional, comorbidity, cognitive, and social assessment. RESULTS: The prevalence of diabetes was 53% and average age 81...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28846029/ayurvedic-preparation-of-zingiber-officinale-roscoe-effects-on-cardiac-and-on-smooth-muscle-parameters
#13
Alberto Leoni, Roberta Budriesi, Ferruccio Poli, Mariacaterina Lianza, Alessandra Graziadio, Alice Venturini, Massimiliano Broccoli, Matteo Micucci
The rhizome of the Zingiber officinale Roscoe, a biennial herb growing in South Asia, is commonly known as ginger. Ginger is used in clinical disorders, such as constipation, dyspepsia, diarrhoea, nausea and vomiting and its use is also recommended by the traditional medicine for cardiopathy, high blood pressure, palpitations and as a vasodilator to improve the circulation. The decoction of ginger rhizome is widely used in Ayurvedic medicine. In this papery by high-performance liquid chromatography, we have seen that its main phytomarkers were 6-gingerol, 8-gingerol and 6-shogaol and we report the effects of the decoction of ginger rhizome on cardiovascular parameters and on vascular and intestinal smooth muscle...
August 28, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28768580/2d-speckle-tracking-right-ventricular-strain-to-assess-right-ventricular-systolic-function-in-systolic-heart-failure-analysis-of-the-right-ventricular-free-and-posterolateral-walls
#14
Stéphanie Mouton, Héléne Ridon, Marie Fertin, Anju Duva Pentiah, Céline Goémine, Grégory Petyt, Nicolas Lamblin, Augustin Coisne, Claude Foucher-Hossein, David Montaigne, Pascal de Groote
BACKGROUND: Right ventricular (RV) systolic function is a powerful prognostic factor in patients with systolic heart failure. The accurate estimation of RV function remains difficult. The aim of the study was to determine the diagnostic accuracy of 2D-speckle tracking RV strain in patients with systolic heart failure, analyzing both free and posterolateral walls. METHODS: Seventy-six patients with dilated cardiopathy (left ventricular end-diastolic volume≥75ml/m(2)) and left ventricular ejection fraction≤45% had an analysis of the RV strain...
July 25, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28763068/experience-in-the-corrective-treatment-of-patients-with-atrioventricular-septum
#15
Yuriria Olivares-Fernández, Áurea Zetina-Solórzano
INTRODUCTION: Atrioventricular septal defects are a wide spectrum of cardiac malformations, from partial until complete with one unique atrioventricular valve, atrioventricular valve communication, and leaky left heart valve. Its fast evolution to pulmonary vascular disease calls for early surgical management. Corrective treatment has a high percentage of re-operations and 8.6% mortality. OBJECTIVES: To describe the results of corrective treatments of atrioventricular septum defects in our institution's patients...
May 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28718666/atrial-cardiopathy-a-mechanism-of-cryptogenic-stroke
#16
Shadi Yaghi, Hooman Kamel, Mitchell S V Elkind
Cryptogenic stroke accounts for approximately 30% of all ischemic strokes. Recently, atrial cardiopathy diagnosed by the presence of one of its serum, imaging, or electrocardiogram biomarkers has been shown to be associated with ischemic stroke, particularly of embolic subtypes. Areas covered: This paper aims to summarize data on occult atrial fibrillation and stroke, provide an overview on mechanisms, such as inflammation and fibrosis, of stroke in atrial cardiopathy, critically review data on biomarkers of atrial cardiopathy and their association with stroke, and suggest therapeutic implications, including directions for future research...
August 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28666806/pr-interval-prolongation-and-cryptogenic-stroke-a-multicenter-retrospective-study
#17
Mayra Montalvo, Prasanna Tadi, Alexander Merkler, Gino Gialdini, Sheryl Martin-Schild, Digvijaya Navalkele, Alyana Samai, Amre Nouh, Mohammad Hussain, Steven Goldblatt, Morgan Hemendinger, Antony Chu, Christopher Song, Hooman Kamel, Karen L Furie, Shadi Yaghi
BACKGROUND: Atrial dysfunction or "cardiopathy" has been recently proposed as a mechanism in cryptogenic stroke. A prolonged PR interval may reflect impaired atrial conduction and thus may be a biomarker of atrial cardiopathy. We aim to compare the prevalence of PR interval prolongation in patients with cryptogenic stroke (CS) when compared with known non-cryptogenic non-cardioembolic stroke (NCNCS) subtypes. METHODS: We used prospective ischemic stroke databases of 3 comprehensive stroke centers to identify patients 18 years or older with a discharge diagnosis of ischemic non-cardioembolic stroke between December 1, 2013 and August 31, 2015...
October 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28658377/variations-and-particularities-in-cardiovascular-disease-mortality-in-brazil-and-brazilian-states-in-1990-and-2015-estimates-from-the-global-burden-of-disease
#18
Luisa Campos Caldeira Brant, Bruno Ramos Nascimento, Valéria Maria Azeredo Passos, Bruce Bartholow Duncan, Isabela Judith Martins Bensenõr, Deborah Carvalho Malta, Maria de Fatima Marinho de Souza, Lenice Harumi Ishitani, Elizabeth França, Mateus S Oliveira, Meghan Mooney, Mohsen Naghavi, Gregory Roth, Antonio Luiz Pinho Ribeiro
Objective: To analyze variations and particularities in mortality due to cardiovascular disease (CVD) in Brazil and in Brazilian states, in 1990 and 2015. Methods: We used data compiled from the Global Burden of Disease (GBD) 2015, obtained from the database of the Mortality Information System (SIM) of the Brazilian Ministry of Health. Correction of the sub-registry of deaths and reclassification of the garbage codes were performed using specific algorithms. The cardiovascular causes were subdivided into 10 specific causes...
May 2017: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/28653161/the-post-sir-spheres-surgery-study-p4s-retrospective-analysis-of-safety-following-hepatic-resection-or-transplantation-in-patients-previously-treated-with-selective-internal-radiation-therapy-with-yttrium-90-resin-microspheres
#19
Fernando Pardo, Bruno Sangro, Rheun-Chuan Lee, Derek Manas, Rohan Jeyarajah, Vincent Donckier, Geert Maleux, Antonio D Pinna, Lourens Bester, David L Morris, David Iannitti, Pierce K Chow, Richard Stubbs, Paul J Gow, Gianluca Masi, Kevin T Fisher, Wan Y Lau, Konstantinos Kouladouros, Georgios Katsanos, Giorgio Ercolani, Fernando Rotellar, José I Bilbao, Michael Schoen
BACKGROUND: Reports show that selective internal radiation therapy (SIRT) may downsize inoperable liver tumors to resection or transplantation, or enable a bridge-to-transplant. A small-cohort study found that long-term survival in patients undergoing resection following SIRT appears possible but no robust studies on postsurgical safety outcomes exist. The Post-SIR-Spheres Surgery Study was an international, multicenter, retrospective study to assess safety outcomes of liver resection or transplantation following SIRT with yttrium-90 (Y-90) resin microspheres (SIR-Spheres(®); Sirtex)...
September 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28619533/-dyslipidemia-management-in-patients-with-high-cardiovascular-risk-in-spain-alma-study
#20
Xavier Pintó, Ferran Trias Vilagut, Joan Rius Taruella, Esther Mairal Sallán
OBJECTIVE: To assess the attitude of primary care (PCPs) and specialized care (SCPs) physicians towards the general set of patients with dyslipidemia, particularly those with cardiovascular risk factors. DESIGN: Observational, descriptive, multi-center study based on a survey. LOCATION: Different healthcare regions in Spain. PARTICIPANTS: 1,402 PCPs, and 596 SCPs. MAIN MEASUREMENTS: Physician's profile, routine practices in the management of patients with dyslipidemia...
June 12, 2017: Atencion Primaria
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