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Hyperthermic conditioning

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https://www.readbyqxmd.com/read/29313151/cnidarian-primary-cell-culture-as-a-tool-to-investigate-the-effect-of-thermal-stress-at-cellular-level
#1
P Ventura, G Toullec, C Fricano, L Chapron, V Meunier, E Röttinger, P Furla, S Barnay-Verdier
In the context of global change, symbiotic cnidarians are largely affected by seawater temperature elevation leading to symbiosis breakdown. This process, also called bleaching, is triggered by the dysfunction of the symbiont photosystems causing an oxidative stress and cell death to both symbiont and host cells. In our study, we wanted to elucidate the intrinsic capacity of isolated animal cells to deal with thermal stress in the absence of symbiont. In that aim, we have characterized an animal primary cell culture form regenerating tentacles of the temperate sea anemone Anemonia viridis...
January 8, 2018: Marine Biotechnology
https://www.readbyqxmd.com/read/29247749/regional-and-long-range-neural-synchronization-abnormality-during-passive-hyperthermia
#2
Wei Han, Shaowen Qian, Qingjun Jiang, Kai Liu, Bo Li, Gang Sun
Passive hyperthermia would impair wide-domain cognitive performances (e.g. attention, working memory), which may involve abnormal regional and long-range neural activity. Combining the regional homogeneity (ReHo) and seed-based functional connectivity analysis, this study investigated the regional and long-range neural synchronization abnormality during passive hyperthermia. We acquired the resting-state blood oxygenation level dependent (BOLD) data from twenty-three healthy male participants in two simulated thermal conditions: normothermic condition (NC) with temperature at 25°C for 1 h and hyperthermic condition (HC) with temperature at 50°C for 1 h...
December 13, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29246446/febrile-temperature-reprograms-by-redox-mediated-signaling-the-mitochondrial-metabolic-phenotype-in-monocyte-derived-dendritic-cells
#3
Marta Menga, Rosa Trotta, Rosella Scrima, Consiglia Pacelli, Veronica Silvestri, Claudia Piccoli, Nazzareno Capitanio, Arcangelo Liso
Fever-like hyperthermia is known to stimulate innate and adaptive immune responses. Hyperthermia-induced immune stimulation is also accompanied with, and likely conditioned by, changes in the cell metabolism and, in particular, mitochondrial metabolism is now recognized to play a pivotal role in this context, both as energy supplier and as signaling platform. In this study we asked if challenging human monocyte-derived dendritic cells with a relatively short-time thermal shock in the fever-range, typically observed in humans, caused alterations in the mitochondrial oxidative metabolism...
December 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29204126/pharmacokinetic-ambulatory-and-hyperthermic-effects-of-3-4-methylenedioxy-n-methylcathinone-methylone-in-rats
#4
Kristýna Štefková, Monika Židková, Rachel R Horsley, Nikola Pinterová, Klára Šíchová, Libor Uttl, Marie Balíková, Hynek Danda, Martin Kuchař, Tomáš Páleníček
Methylone (3,4-methylenedioxy-N-methylcathinone) is a synthetic cathinone analog of the recreational drug ecstasy. Although it is marketed to recreational users as relatively safe, fatalities due to hyperthermia, serotonin syndrome, and multi-organ system failure have been reported. Since psychopharmacological data remain scarce, we have focused our research on pharmacokinetics, and on a detailed evaluation of temporal effects of methylone and its metabolite nor-methylone on behavior and body temperature in rats...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29184697/clinical-presentation-diagnosis-classification-and-management-of-peritoneal-mesothelioma-a-review
#5
REVIEW
Alfonso García-Fadrique, Akash Mehta, Faheez Mohamed, Sanjeev Dayal, Tom Cecil, Brendan J Moran
Peritoneal mesothelioma (PM) is an uncommon but a serious, and often, fatal primary peritoneal tumour, with increasing incidence worldwide. Conventional systemic chemotherapy, generally based on experience with pleural mesothelioma, usually has disappointing results considering PM as a terminal condition. Patients usually present with non-specific symptoms of abdominal distension and pain making the diagnosis challenging. As PM is confined to the abdomen for all, or much, of its clinical course, a multimodality treatment combining cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has emerged as a new standard of care, and has been reported to achieve promising survival outcomes and local disease control in selected patients with PM...
October 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29150040/management-of-malignant-lung-entrapment-the-oncothorax
#6
REVIEW
Roman Petrov, Charles Bakhos, Abbas E Abbas
Pleural metastasis is a common occurrence in up to 30% of patients with metastatic cancer. When lung entrapment and loculation of fluid occur, treatment is more difficult and we have named this condition "oncothorax." The malignant adhesions that entrap the lung in an oncothorax are not typically amenable to surgical decortication. The standard approach for managing these patients is to place an indwelling catheter. Other options may include pleurectomy and decortication, intrapleural hyperthermic chemoperfusion, and intrapleural photodynamic therapy...
February 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29147526/a-ratiometric-fluorescent-probe-for-imaging-and-quantifying-anti-apoptotic-effects-of-gsh-under-temperature-stress
#7
Xiaoyue Han, Xinyu Song, Fabiao Yu, Lingxin Chen
Hypothermia and hyperthermia are cell stressed states resulting from environmental temperature changes, which can abnormally decrease intracellular glutathione (GSH) concentrations and induce apoptosis. As the most abundant intracellular non-protein biothiol, GSH can protect cells from apoptosis. Considering the important roles of GSH in the anti-apoptotic process in cells and in vivo, we strive to develop a powerful chemical tool for the direct detection of GSH concentration changes under temperature stress...
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29112514/effects-of-intravenous-cold-saline-on-hyperthermic-athletes-representative-of-large-football-players-and-small-endurance-runners
#8
Katherine E Morrison, Natasha Desai, Christopher McGuigan, Megan Lennon, Sandra Fowkes Godek
OBJECTIVE: To evaluate the cooling effects of intravenous (IV) cold normal (0.9%) saline on hyperthermic athletes. DESIGN: Randomized crossover study design. SETTING: Controlled research laboratory. PARTICIPANTS: Twelve male participants who were representative of a collegiate cross-country (6) and American football (6) population. INTERVENTIONS: Participants underwent body composition analysis using a BodPod...
October 27, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29111382/innovative-approach-to-safely-induce-controlled-lipolysis-by-superparamagnetic-iron-oxide-nanoparticles-mediated-hyperthermic-treatment
#9
Maria Rosaria Marinozzi, Laura Pandolfi, Manuela Malatesta, Miriam Colombo, Veronica Collico, Patricia Marie-Jeanne Lievens, Stefano Tambalo, Chiara Lasconi, Federica Vurro, Federico Boschi, Silvia Mannucci, Andrea Sbarbati, Davide Prosperi, Laura Calderan
During last years, evidence has been provided on the involvement of overweight and obesity in the pathogenesis and aggravation of several life-threatening diseases. Here, we demonstrate that, under appropriate administration conditions, polyhedral iron oxide nanoparticles are efficiently and safely taken up by 3T3 cell line-derived adipocytes (3T3 adipocytes) in vitro. Since these nanoparticles proved to effectively produce heat when subjected to alternating magnetic field, 3T3 adipocytes were submitted to superparamagnetic iron oxide nanoparticles-mediated hyperthermia treatment (SMHT), with the aim of modulating their lipid content...
October 27, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29108718/a-new-animal-model-for-hyperthermic-intraperitoneal-chemotherapy-hipec-in-tumor-bearing-mice-in-the-treatment-of-peritoneal-carcinomatosis-of-ovarian-origin
#10
G Miailhe, A Arfi, M Mirshahi, C Eveno, M Pocard, C Touboul
AIM OF THE STUDY: We set out to develop and evaluate the morbidity of a non-invasive hyperthermic intraperitoneal chemotherapy (HIPEC) procedure in mice. HIPEC has been shown to improve overall survival in treating ovarian cancer with peritoneal carcinomatosis. However, related complications, toxicity and the lack of randomized trials limits its widespread use. To improve the surgical technique, there is a need for animal models that allow teams to work on large groups without burdensome logistics...
November 3, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29108477/hyperthermia-and-mild-traumatic-brain-injury-effects-on-inflammation-and-the-cerebral-vasculature
#11
Jessie Truettner, Helen M Bramlett, W Dalton Dietrich
Mild traumatic brain injury (mTBI) or concussion represents the majority of TBIs brain trauma in the United States. The pathophysiology of mTBI is complex and may include both focal and diffuse injury patterns. In addition to altered circuit dysfunction and diffuse traumatic axonal injury (DTAI), chronic neuroinflammation has also been implicated in the pathophysiology of mTBI. Recently, our laboratory has reported the detrimental effects of mild hyperthermic mTBI in terms of worsening histopathological and behavioral outcomes...
November 6, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29089991/effect-of-hyperthermia-on-calbindin-d-28k-immunoreactivity-in-the-hippocampal-formation-following-transient-global-cerebral-ischemia-in-gerbils
#12
Jae-Chul Lee, Jeong-Hwi Cho, Tae-Kyeong Lee, In Hye Kim, Moo-Ho Won, Geum-Sil Cho, Bich-Na Shin, In Koo Hwang, Joon Ha Park, Ji Hyeon Ahn, Il Jun Kang, Young Joo Lee, Yang Hee Kim
Calbindin D-28K (CB), a Ca(2+)-binding protein, maintains Ca(2+) homeostasis and protects neurons against various insults. Hyperthermia can exacerbate brain damage produced by ischemic insults. However, little is reported about the role of CB in the brain under hyperthermic condition during ischemic insults. We investigated the effects of transient global cerebral ischemia on CB immunoreactivity as well as neuronal damage in the hippocampal formation under hyperthermic condition using immunohistochemistry for neuronal nuclei (NeuN) and CB, and Fluoro-Jade B histofluorescence staining in gerbils...
September 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29089784/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-appendiceal-goblet-cell-carcinomas-with-peritoneal-carcinomatosis-results-from-a-single-specialized-center
#13
Hsin-Hsien Yu, Yutaka Yonemura, Mao-Chih Hsieh, Akiyoshi Mizumoto, Satoshi Wakama, Chang-Yun Lu
BACKGROUND: Goblet cell carcinomas (GCCs) of the appendix are rare and aggressive malignancies with early peritoneal dissemination. The aim of the present article is to describe our experience in the management of GCCs with peritoneal carcinomatosis (PC) through cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) and to determine the impact of multiple clinical characteristics on the prognosis. METHODS: From a prospectively maintained database of patients receiving CRS and HIPEC for peritoneal surface malignancy, the data of 15 patients with GCC and PC were collected...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29060699/hyperthermia-dependence-of-cardiac-conduction-velocity-in-rat-myocardium-optical-mapping-and-cardiac-near-field-measurements
#14
Stefan Pollnow, Robert Arnold, Matthias Werber, Olaf Dossel, Gunnar Seemann
Hyperthermia during radiofrequency ablation causes reversible and irreversible changes of the electrophysiological properties of cardiac tissue. However, the mechanisms are incompletely understood. We studied changes of conduction velocity (CV) in rat myocardium under hyperthermic conditions from macroscopic to microscopic scale by using simultaneous optical mapping and a miniaturized electrode array. Atrial preparations from five rats were superfused at tissue bath temperatures between 36.7°C and 43.8°C...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29021627/dispersal-of-thermophilic-beetles-across-the-intercontinental-arctic-forest-belt-during-the-early-eocene
#15
Adam J Brunke, Stylianos Chatzimanolis, Brian D Metscher, Karin Wolf-Schwenninger, Alexey Solodovnikov
Massive biotic change occurred during the Eocene as the climate shifted from warm and equable to seasonal and latitudinally stratified. Mild winter temperatures across Arctic intercontinental land bridges permitted dispersal of frost-intolerant groups until the Eocene-Oligocene boundary, while trans-Arctic dispersal in thermophilic groups may have been limited to the early Eocene, especially during short-lived hyperthermals. Some of these lineages are now disjunct between continents of the northern hemisphere...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28992447/magnetic-hyperthermia-efficiency-and-mri-contrast-sensitivity-of-colloidal-soft-hard-ferrite-nanoclusters
#16
Kosmas Vamvakidis, Stefanos Mourdikoudis, Antonis Makridis, Eleni Paulidou, Mavroeidis Angelakeris, Catherine Dendrinou-Samara
The use of magnetic nanostructures as theranostic agents is a multiplex task as physiochemical and biochemical properties including excellent magneto-responsive properties, low toxicity, colloidal stability and facile surface engineering capability are all required. Nonetheless, much progress has been made in recent years synthesis of "all-in-one" MNPs remain unambiguously challenging. Towards this direction, in this study is presented a facile incorporation of a soft magnetic phase (MnFe2O4 NPs) with a hard phase (CoFe2O4 NPs) in the presence of the biocompatible polymer sodium dodecyl sulfate (SDS), into spherical and compact bi-magnetic nanoclusters (NCs) with modulated magnetic properties that critically enhance hyperthermic efficiency and MRI contrast effect...
October 3, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28992254/latitudinal-clines-in-temperature-and-salinity-tolerance-in-tidepool-copepods
#17
Wai Leong, Patrick Y Sun, Suzanne Edmands
Local adaptation has been understudied in marine systems, but might be expected to be pronounced in the tidepool copepod Tigriopus californicus, which has a broad geographic range and extremely restricted dispersal. Tolerance to temperature and salinity was assessed in 14 populations over a 20° latitudinal range. Adaptive differentiation to temperature and salinity was found at scales as low as 5.6 km. Latitudinal clines were significant, with northern populations being more tolerant of low salinity and less tolerant of high temperature and high salinity...
July 18, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28977828/human-monocyte-derived-dendritic-cells-exposed-to-hyperthermia-show-a-distinct-gene-expression-profile-and-selective-upregulation-of-igfbp6
#18
Arcangelo Liso, Stefano Castellani, Francesca Massenzio, Rosa Trotta, Alessandra Pucciarini, Barbara Bigerna, Pasquale De Luca, Pietro Zoppoli, Filippo Castiglione, Maria Concetta Palumbo, Fabrizio Stracci, Matteo Landriscina, Giorgina Specchia, Leon A Bach, Massimo Conese, Brunangelo Falini
Fever plays a role in activating innate immunity while its relevance in activating adaptive immunity is less clear. Even brief exposure to elevated temperatures significantly impacts on the immunostimulatory capacity of dendritic cells (DCs), but the consequences on immune response remain unclear. To address this issue, we analyzed the gene expression profiles of normal human monocyte-derived DCs from nine healthy adults subjected either to fever-like thermal conditions (39°C) or to normal temperature (37°C) for 180 minutes...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976512/enhanced-blood-brain-barrier-permeability-and-glioblastoma-cell-targeting-via-thermoresponsive-lipid-nanoparticles
#19
M Rehman, A Madni, D Shi, A Ihsan, N Tahir, K R Chang, I Javed, T J Webster
Thermoresponsive targeting is used to deliver therapeutic agents at hyperthermic conditions (39-45 °C). However, available thermoresponsive drug delivery systems (TDDS), including liposomes, have a complex method of preparation involving toxic solvents and reagents. The objective of this in vitro study was to prepare and characterize thermoresponsive lipid nanoparticles (TLN) for treating glioblastoma, the most aggressive brain tumor whose treatment is limited by a low blood brain barrier (BBB) permeability of drugs...
October 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28974122/activation-of-hypoxia-inducible-factor-1%C3%AE-in-rat-brain-after-perinatal-anoxia-role-of-body-temperature
#20
Hanna Kletkiewicz, Malwina Hyjek, Krzysztof Jaworski, Anna Nowakowska, Justyna Rogalska
Transcriptional hypoxia-inducible factor-1α (HIF-1α) plays the fundamental role in adaptive processes in response to hypoxia. Specific HIF-1α target genes are involved in glycolysis, erythropoiesis and angiogenesis to promote survival. In our previous study we have demonstrated that naturally low body temperature of newborn rats protects them against damage due to perinatal hypoxia. Therefore, our experiments aimed at checking the effects of body temperature during simulated perinatal anoxia on subsequent changes of expression of HIF-1α and its specific target genes such as vascular endothelial growth factor (VEGF) and erythropoietin (EPO) in the rat brain...
October 23, 2017: International Journal of Hyperthermia
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