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Hyperthermic conditioning

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https://www.readbyqxmd.com/read/28366987/amplification-of-glutathione-mediated-oxidative-stress-by-catalase-in-an-aqueous-solution-at-hyperthermal-temperatures
#1
Megumi Ueno, Emiko Sekine-Suzuki, Minako Nyui, Ikuo Nakanishi, Ken-Ichiro Matsumoto
The glutathione (GSH)-mediated superoxide (O2(•-)) generation in an aqueous solution and relation of hydrogen peroxide (H2O2) and effect of catalase were investigated. GSH-induced O2(•-) generation in hyperthermal temperatures was measured by the nitroblue tetrazolium (NBT) mehod. Heating an aqueous solution containing GSH caused superoxide from dissolved O2. H2O2 was generated simultaneously in this reaction mixture probably from the hydroperoxy radical (HO2(•)), which is equilibrated with O2(•-) in an aqueous condition, and then H2O2 consumed O2(•-)...
March 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/28351399/effects-of-hyperthermic-baths-on-depression-sleep-and-heart-rate-variability-in-patients-with-depressive-disorder-a-randomized-clinical-pilot-trial
#2
RANDOMIZED CONTROLLED TRIAL
Johannes Naumann, Julian Grebe, Sonja Kaifel, Tomas Weinert, Catharina Sadaghiani, Roman Huber
BACKGROUND: Despite advances in the treatment of depression, one-third of depressed patients fail to respond to conventional antidepressant medication. There is a need for more effective treatments with fewer side effects. The primary aim of this study was to determine whether hyperthermic baths reduce depressive symptoms in adults with depressive disorder. METHODS: Randomized, two-arm placebo-controlled, 8-week pilot trial. Medically stable outpatients with confirmed depressive disorder (ICD-10: F32/F33) who were moderately depressed as determined by the 17-item Hamilton Scale for Depression (HAM-D) score ≥18 were randomly assigned to 2 hyperthermic baths (40 °C) per week for 4 weeks or a sham intervention with green light and follow-up after 4 weeks...
March 28, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28343583/indirect-hand-and-forearm-vasomotion-regional-variations-in-cutaneous-thermosensitivity-during-normothermia-and-mild-hyperthermia
#3
Catriona A Burdon, Kyoko Tagami, Joonhee Park, Joanne N Caldwell, Nigel A S Taylor
In this experiment, hand and forearm vasomotor activity was investigated during localised, but stable heating and cooling of the face, hand and thigh, under open-loop (clamped) conditions. It was hypothesised that facial stimulation would provoke the most potent vascular changes. Nine individuals participated in two normothermic trials (mean body temperature clamp: 36.6°C; water-perfused suit and climate chamber) and two mildly hyperthermic trials (37.9°C). Localised heating (+5°C) and cooling (-5°C) stimuli were applied to equal surface areas of the face, hand and thigh (perfusion patches: 15min), while contralateral forearm or hand blood flows (venous-occlusion plethysmography) were measured (separate trials)...
April 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28319750/unfavorable-effect-of-levetiracetam-on-cultured-hippocampal-neurons-after-hyperthermic-injury
#4
Krzysztof Sendrowski, Piotr Sobaniec, Elżbieta Poskrobko, Małgorzata Rusak, Wojciech Sobaniec
BACKGROUND: The aim of this study was to examine the viability of neurons and the putative neuroprotective effects of second-generation antiepileptic drug, levetiracetam (LEV), on cultured hippocampal neurons injured by hyperthermia. METHODS: Primary cultures of rat's hippocampal neurons at 7day in vitro (DIV) were incubated in the presence or absence of LEV in varied concentrations under hyperthermic conditions. Cultures were heated in a temperature of 40°C for 24h or in a temperature of 41°C for 6h...
January 24, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28297683/effects-of-hypothermia-on-the-mechanical-behavior-of-rabbit-femoral-arteries
#5
Kozaburo Hayashi, Yuki Kurose
The need to better understand the effects of non-physiological temperatures on arterial wall behavior is becoming more important because of the increased clinical use of hypothermal and hyperthermal treatments. The present study was performed to examine the effects of temperature on the mechanical behavior of femoral arteries excised from rabbits. Among 17, 27, 37, and 42°C, there were no significant differences in their diameter, stiffness, and P-D relations under the physiologically normal, control condition, although the arterial diameter was slightly smaller at 42°C than at the other three temperatures...
March 6, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28256298/contribution-of-mitochondria-to-injury-of-hepatocytes-and-liver-tissue-by-hyperthermia
#6
Rasa Žūkienė, Zita Naučienė, Giedrė Šilkūnienė, Tomas Vanagas, Antanas Gulbinas, Aurelijus Zimkus, Vida Mildažienė
OBJECTIVE: The aim of this study was to investigate functional changes of liver mitochondria within the experimentally modeled transition zone of radiofrequency ablation and to estimate possible contribution of these changes to the energy status of liver cells and the whole tissue. MATERIALS AND METHODS: Experiments were carried out on mitochondria isolated from the perfused liver and isolated hepatocytes of male Wistar rats. Hyperthermia was induced by changing the temperature of perfusion medium in the range characteristic for the transition zone (38-52°C)...
January 9, 2017: Medicina
https://www.readbyqxmd.com/read/28222738/are-there-intra-operative-hemodynamic-differences-between-the-coliseum-and-closed-hipec-techniques-in-the-treatment-of-peritoneal-metastasis-a-retrospective-cohort-study
#7
Cristina Rodríguez Silva, Francisco Javier Moreno Ruiz, Inmaculada Bellido Estévez, Joaquin Carrasco Campos, Alberto Titos García, Manuel Ruiz López, Ivan González Poveda, Jose Antonio Toval Mata, Santiago Mera Velasco, Julio Santoyo Santoyo
BACKGROUND: Although two main methods of intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) are currently accepted, the superiority of one over the other has not yet been demonstrated. The purpose of this study was to determine whether there are hemodynamic and temperature differences between patients who received HIPEC in two different techniques, open versus closed abdomen. METHODS: This retrospective study was conducted in our center between 2011-2015 in 30 patients who underwent surgery for peritoneal carcinomatosis secondary to colorectal cancer, in whom cytoreduction and HIPEC were performed by the Coliseum (15) or closed techniques (15)...
February 21, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28202230/intergenerational-transmission-of-enhanced-seizure-susceptibility-after-febrile-seizures
#8
Dengchang Wu, Bo Feng, Yunjian Dai, Xiaohua Wu, Bin Chen, Cenglin Xu, Yangshun Tang, Kang Wang, Shihong Zhang, Shuang Wang, Benyan Luo, Zhong Chen
Environmental exposure early in development plays a role in susceptibility to disease in later life. Here, we demonstrate that prolonged febrile seizures induced by exposure of rat pups to a hyperthermic environment enhance seizure susceptibility not only in these hyperthermia-treated rats but also in their future offspring, even if the offspring never experience febrile seizures. This transgenerational transmission was intensity-dependent and was mainly from mothers to their offspring. The transmission was associated with DNA methylation...
March 2017: EBioMedicine
https://www.readbyqxmd.com/read/28178820/preface-special-topic-on-atomic-and-molecular-layer-processing-deposition-patterning-and-etching
#9
James R Engstrom, Andrew C Kummel
Thin film processing technologies that promise atomic and molecular scale control have received increasing interest in the past several years, as traditional methods for fabrication begin to reach their fundamental limits. Many of these technologies involve at their heart phenomena occurring at or near surfaces, including adsorption, gas-surface reactions, diffusion, desorption, and re-organization of near-surface layers. Moreover many of these phenomena involve not just reactions occurring under conditions of local thermodynamic equilibrium but also the action of energetic species including electrons, ions, and hyperthermal neutrals...
February 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28168311/impact-of-laparotomy-and-intraperitoneal-hyperthermic-instillation-lihi-on-the-oxaliplatin-pharmacokinetics-after-intravenous-administration-in-wistar-rats
#10
María Isabel Mas-Fuster, Amelia Ramon-Lopez, Javier Lacueva, Antonio Compañ, Patricio Más-Serrano, Ricardo Nalda-Molina
PURPOSE: In peritoneal metastasis condition, the fact that most of the disease is limited to the peritoneal cavity laid the foundations for a surgical treatment, including intraperitoneal hyperthermic chemotherapy (HIPEC). The aim of this study was to evaluate the impact of the surgical procedures implied in open HIPEC technique, referred to laparotomy procedures followed by an intraperitoneal hyperthermic instillation (LIHI) on oxaliplatin tissue distribution and elimination. To delimit the influence of this procedure alone, oxaliplatin was administered as an intravenous (iv) bolus in both groups...
February 6, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28162872/simple-and-effective-method-to-lower-body-core-temperatures-of-hyperthermic-patients
#11
John P O'Connor
Hyperthermia is a potentially life threatening scenario that may occur in patients due to accompanying morbidities, exertion, or exposure to dry and arid environmental conditions. In particular, heat stroke may result from environmental exposure combined with a lack of thermoregulation. Key clinical findings in the diagnosis of heatstroke are (1) a history of heat stress or exposure, (2) a rectal temperature greater than 40 °C, and (3) central nervous system dysfunction (altered mental state, disorientation, stupor, seizures, or coma) (Prendergast and Erickson, 2014 [1])...
January 30, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28108645/whole-body-hyperthermia-but-not-skin-hyperthermia-accelerates-brain-and-locomotor-limb-circulatory-strain-and-impairs-exercise-capacity-in-humans
#12
Steven J Trangmar, Scott T Chiesa, Kameljit K Kalsi, Niels H Secher, José González-Alonso
Cardiovascular strain and hyperthermia are thought to be important factors limiting exercise capacity in heat-stressed humans, however, the contribution of elevations in skin (Tsk) versus whole body temperatures on exercise capacity has not been characterized. To ascertain their relationships with exercise capacity, blood temperature (TB), oxygen uptake (V̇O2), brain perfusion (MCA Vmean), locomotor limb hemodynamics, and hematological parameters were assessed during incremental cycling exercise with elevated skin (mild hyperthermia; HYPmild), combined core and skin temperatures (moderate hyperthermia; HYPmod), and under control conditions...
January 2017: Physiological Reports
https://www.readbyqxmd.com/read/28059418/highly-versatile-spion-encapsulated-plga-nanoparticles-as-photothermal-ablators-of-cancer-cells-and-as-multimodal-imaging-agents
#13
Balasubramanian Sivakumar, Ravindran Girija Aswathy, Rebeca Romero-Aburto, Trevor Mitcham, Keith A Mitchel, Yutaka Nagaoka, Richard R Bouchard, Pulickel M Ajayan, Toru Maekawa, Dasappan Nair Sakthikumar
We have designed versatile polymeric nanoparticles with cancer cell specific targeting capabilities via aptamer conjugation after the successful encapsulation of curcumin and superparamagnetic iron oxide nanoparticles (SPIONs) inside a PLGA nanocapsule. These targeted nanocomposites were selectively taken up by tumor cells, under in vitro conditions, demonstrating the effectiveness of the aptamer targeting mechanism. Moreover, the nanocomposite potentially functioned as efficient multiprobes for optical, magnetic resonance imaging (MRI) and photoacoustic imaging contrast agents in the field of cancer diagnostics...
January 6, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28033247/outcomes-of-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-colorectal-cancer-with-peritoneal-metastasis
#14
En-Kwang Lin, Mao-Chih Hsieh, Chien-Hsin Chen, Yen-Jung Lu, Szu-Yuan Wu
In Taiwan, colorectal cancer with peritoneal carcinomatosis is considered a terminal condition. We examined the clinical outcomes of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) treatment for colorectal cancer with peritoneal carcinomatosis in Taiwan.We enrolled patients with colorectal cancer and peritoneal metastasis from Taipei Medical University, Wanfang Hospital between January 1999 and December 2014. Of the enrolled patients, 3 had mucinous-type tumors. In total, we enrolled 31 patients who underwent a total of 33 procedures...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27960434/resistance-of-poss-polyimide-blends-to-hyperthermal-atomic-oxygen-attack
#15
Min Qian, Vanessa J Murray, Wei Wei, Brooks C Marshall, Timothy K Minton
Copolymers of polyhedral oligomeric silsesquioxane (POSS) and polyimide (PI) have shown remarkable resistance to atomic oxygen (AO) attack and have been proposed as replacements for Kapton on the external surfaces of spacecraft in the harsh oxidizing environment of low Earth orbit (LEO). POSS PI blends would be an economical alternative to the copolymers if they also resisted AO attack. Thus, blends of trisilanolphenyl (TSP) POSS and PI with different weight percentages of the Si7O9 POSS cage were cast into films and exposed to a hyperthermal AO beam, and they were characterized in terms of their recession, mass loss, surface morphology, and surface chemistry...
December 14, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27920896/assessing-the-hyperthermic-properties-of-magnetic-heterostructures-the-case-of-gold-iron-oxide-composites
#16
Elvira Fantechi, Paula M Castillo, Erika Conca, Francesca Cugia, Claudio Sangregorio, Maria Francesca Casula
Gold-iron oxide composites were obtained by in situ reduction of an Au(III) precursor by an organic reductant (either potassium citrate or tiopronin) in a dispersion of preformed iron oxide ultrasmall magnetic (USM) nanoparticles. X-ray diffraction, transmission electron microscopy, chemical analysis and mid-infrared spectroscopy show the successful deposition of gold domains on the preformed magnetic nanoparticles, and the occurrence of either citrate or tiopronin as surface coating. The potential of the USM@Au nanoheterostructures as heat mediators for therapy through magnetic fluid hyperthermia was determined by calorimetric measurements under sample irradiation by an alternating magnetic field with intensity and frequency within the safe values for biomedical use...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27903515/passive-heat-acclimation-improves-skeletal-muscle-contractility-in-humans
#17
Sebastien Racinais, Mathew G Wilson, Julien D Périard
The aim of this study was to investigate the effect of repeated passive heat exposure (i.e. acclimation) on muscle contractility in humans. Fourteen non-heat acclimated males completed two trials including electrically evoked twitches and voluntary contractions in thermoneutral conditions (COOL: 24ºC, 40% RH) and hot ambient conditions in the hyperthermic state (HOT: 44-50ºC, 50% RH) on consecutive days in a counterbalanced order. Rectal temperature was ~36.5ºC in COOL and was maintained at ~39ºC throughout HOT...
November 30, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27892715/incorporation-of-chemotherapeutic-agent-and-photosensitizer-in-a-low-temperature-sensitive-liposome-for-effective-chemo-hyperthermic-anticancer-activity
#18
Hanh Thuy Nguyen, Tuan Hiep Tran, Raj Kumar Thapa, Tung Thanh Pham, Jee-Heon Jeong, Yu Seok Youn, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
OBJECTIVES: In this study, we combined chemo- and hyperthermia therapy in a low temperature-sensitive liposome (LTSL) for potential cancer treatment. METHODS: Docetaxel (DOC) and indocyanine green (ICG) as a therapeutic agent and photosensitizer, respectively, were incorporated in a low temperature-sensitive liposome (LTSL/DI). Nanoparticles were evaluated for the physicochemical characterizations, in vitro uptake and cytotoxicity, and furthermore in vivo anticancer activity...
December 7, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27865532/tarp-assisted-cooling-as-a-method-of-whole-body-cooling-in-hyperthermic-individuals
#19
Yuri Hosokawa, William M Adams, Luke N Belval, Lesley W Vandermark, Douglas J Casa
STUDY OBJECTIVE: We investigated the efficacy of tarp-assisted cooling as a body cooling modality. METHODS: Participants exercised on a motorized treadmill in hot conditions (ambient temperature 39.5°C [103.1°F], SD 3.1°C [5.58°F]; relative humidity 38.1% [SD 6.7%]) until they reached exercise-induced hyperthermia. After exercise, participants were cooled with either partial immersion using a tarp-assisted cooling method (water temperature 9.20°C [48.56°F], SD 2...
March 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27812726/avian-thermoregulation-in-the-heat-efficient-evaporative-cooling-in-two-southern-african-nightjars
#20
Ryan S O'Connor, Blair O Wolf, R Mark Brigham, Andrew E McKechnie
Nightjars represent a model taxon for investigating physiological limits of heat tolerance because of their habit of roosting and nesting in sunlit sites during the heat of the day. We investigated the physiological responses of Rufous-cheeked nightjars (Caprimulgus rufigena) and Freckled nightjars (Caprimulgus tristigma) to high air temperatures (T a) by measuring body temperature (T b), resting metabolic rate (RMR) and total evaporative water loss (TEWL) at T a ranging from 10 to 56 °C. Both species became hyperthermic at T a > T b...
November 3, 2016: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
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