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Hyperthermic conditioning

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https://www.readbyqxmd.com/read/28943248/the-medial-preoptic-area-modulates-autonomic-function-under-resting-and-stress-conditions
#1
Aline Fassini, América A Scopinho, Fernando H F Alves, Eduardo A T Fortaleza, Fernando M A Corrêa
The medial preoptic area (mPOA) participates in the temperature and cardiovascular control. The mPOA receives inputs from limbic structures and sends projections to hypothalamus and brainstem. Moreover, stress elicits pronounced neuronal activation in mPOA, suggesting its involvement in central neural pathway mediating stress responses. In the present study, we report the effect of acute mPOA neurotransmission inhibition using cobalt chloride (CoCl2-nonselective synapse blocker) on the mean arterial pressure (MAP), heart rate (HR), body and tail temperature (Tbody and Ttail, respectively), as well as on the HR component of baroreflex...
September 21, 2017: Neuroscience
https://www.readbyqxmd.com/read/28927330/thalamocortical-neural-responses-during-hyperthermia-a-resting-state-functional-mri-study
#2
Jing Zhang, Shaowen Qian, Qingjun Jiang, Guanzhong Gong, Kai Liu, Bo Li, Yong Yin, Gang Sun
The neural responses during hyperthermia, once thought of as simple physiological processes (e.g. thermal sensation and regulation), have now been recognized involving more cognitive processes, which would be highly of importance to the management of those occupations during heavy heat exposure. Previous studies have demonstrated altered activity in localized subcortical clusters for thermal sensation and regulation, as well as cortical-cortical activity for behavioral tasks during hyperthermia. However, the involvement of cortical-subcortical activity during hyperthermia has not been investigated...
September 19, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28887185/role-of-monoaminergic-systems-and-ambient-temperature-in-bath-salts-constituent-3-4-methylenedioxypyrovalerone-mdpv-elicited-hyperthermia-and-locomotor-stimulation-in-mice
#3
REVIEW
Brenda M Gannon, Adrian Williamson, Kenner C Rice, William E Fantegrossi
3,4-Methylenedioxypyrovalerone (MDPV) is a common constituent of illicit bath salts products, and in vitro studies implicate monoamine transporters as mediators of its pharmacological effects. Locomotor and thermoregulatory effects of MDPV depend on ambient temperature, so the current studies aimed to gauge the involvement of dopamine (DA), norepinephrine (NE), and serotonin (5-HT) in MDPV-induced locomotor stimulation and hyperthermia in the mouse at different ambient temperatures. Mice were pretreated with the selective 5-HT-reuptake inhibitor fluoxetine (3 mg/kg), the NE-reuptake inhibitor desipramine (3 mg/kg), the DA-reuptake inhibitor bupropion (10 mg/kg), or saline, followed by 10 mg/kg MDPV while thermoregulation and locomotor activity were monitored via radiotelemetry...
September 5, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28870927/response-of-ovcar-3-cells-to-cisplatin-and-hyperthermia-does-hyperthermia-really-matter
#4
Arturas Sukovas, Vaidotas Cesna, Aldona Jasukaitiene, Giedrius Barauskas, Ruta Jolanta Nadisauskiene, Zilvinas Dambrauskas, Saulius Paskauskas, Antanas Gulbinas
BACKGROUND: Hyperthermic intraperitoneal chemotherapy (HIPEC) is proposed as a promising treatment method, but fundamental information about the contribution of hyperthermia to intraperitoneal chemotherapy is lacking. The purpose of this study was to investigate the cytotoxic effect of hyperthermia and cisplatin on OVCAR-3 cells in vitro. MATERIALS AND METHODS: Imitating the typical clinical conditions of HIPEC, OVCAR-3 cells were exposed to hyperthermia and cisplatin for 1 h...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28833689/cold-water-immersion-kill-or-cure
#5
M J Tipton, N Collier, H Massey, J Corbett, M Harper
What is the topic of this review? This is the first review to look across the broad field of 'cold water immersion' and to determine the threats and benefits associated with it as both a hazard and a treatment. What advances does it highlight? The level of evidence supporting each of the areas reviewed is assessed. Like other environmental constituents, such as pressure, heat and oxygen, cold water can be either good or bad, threat or treatment, depending on circumstance. Given the current increase in the popularly of open cold water swimming, it is timely to review the various human responses to cold water immersion (CWI) and consider the strength of the claims made for the effects of CWI...
August 23, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28830980/acute-heat-stress-activated-inflammatory-signaling-in-porcine-oxidative-skeletal-muscle
#6
Shanthi Ganesan, Olga Volodina, Sarah C Pearce, Nicholas K Gabler, Lance H Baumgard, Robert P Rhoads, Joshua T Selsby
Despite well-studied clinical manifestations, intracellular mechanisms of prolonged hyperthermic injury remain unclear, especially in skeletal muscle. Given muscle's large potential to impact systemic inflammation and metabolism, the response of muscle cells to heat-mediated injury warrants further investigation. We have previously reported increased activation of NF-κB signaling and increased NF-κB and AP-1-driven transcripts in oxidative skeletal muscle following 12 h of heat stress. The purpose of this investigation was to examine early heat stress-induced inflammatory signaling in skeletal muscle...
August 2017: Physiological Reports
https://www.readbyqxmd.com/read/28797634/ecological-distribution-of-extremely-thermophilic-bacteria-belonging-to-the-genus-calditerricola-using-the-novel-enrichment-mpn-pcr-method
#7
Kathrina Mae Bienes, Minoru Ito, Kota Shiotsuka, Sachi Yamaguchi, Taiki Fujioka, Yukihiro Tashiro, Kenji Sakai
A unique compost called Satsuma soil is produced from sewage sludge by a hyperthermal composting process in Kagoshima City, Japan. The composting process is carried out at a controlled temperature of at least 80°C and the resulting compost might be useful for recycling sustainable agricultural products. The extremely thermophilic bacterial genus Calditerricola was initially isolated from the high-temperature compost. Likewise, the bacteria were previously isolated from material sludge. It is believed that bacteria in this genus might be involved in the hyperthermal composting process...
August 7, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28755887/brain-temperature-effects-of-intravenous-heroin-state-dependency-environmental-modulation-and-the-effects-of-dose
#8
R Aaron Bola, Eugene A Kiyatkin
Here we examined how intravenous heroin at a dose that maintains self-administration (0.1 mg/kg) affects brain temperature homeostasis in freely moving rats under conditions that seek to mimic some aspects of human drug use. When administered under standard laboratory conditions (quiet rest at 22 °C ambient temperature), heroin induced moderate temperature increases (1.0-1.5 °C) in the nucleus accumbens (NAc), a critical structure of the brain motivation-reinforcement circuit. By simultaneously recording temperatures in the temporal muscle and skin, we demonstrate that the hyperthermic effects of heroin results primarily from inhibition of heat loss due to strong and prolonged skin vasoconstriction...
July 26, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28743181/feasibility-and-safety-of-hyperthermic-intraperitoneal-chemotherapy-using-5-fluorouracil-combined-with-cisplatin-and-mitomycin-c-in-patients-undergoing-gastrectomy-for-advanced-gastric-cancer
#9
Satoshi Murata, Hiroshi Yamamoto, Hiroyuki Naitoh, Tsuyoshi Yamaguchi, Sachiko Kaida, Tomoharu Shimizu, Hisanori Shiomi, Shigeyuki Naka, Tohru Tani, Masaji Tani
BACKGROUND AND OBJECTIVES: We conducted a dose-finding study for 5-fluorouracil (5-FU) administered with cisplatin (CDDP) and mitomycin C (MMC) to find an improved regimen for hyperthermic intraperitoneal chemotherapy (HIPEC) for advanced gastric cancer (GC). METHODS: The appropriate HIPEC regimen previously determined in vitro was 5-FU (200 µg/mL), MMC (2 µg/mL), and CDDP (10 µg/mL) at hyperthermic conditions (42°C) for 30 min. This was a clinical study to determine the recommended dose of 5-FU in combination with MMC and CDDP at 42°C for 30 min and to evaluate HIPEC safety in patients at high risk of developing peritoneal metastases following GC surgery...
July 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28715283/temperate-water-immersion-as-a-treatment-for-hyperthermic-humans-wearing-american-football-uniforms
#10
Kevin C Miller, Tyler Truxton, Blaine Long
CONTEXT:   Cold-water immersion (CWI; 10°C) can effectively reduce body core temperature even if a hyperthermic human is wearing a full American football uniform (PADS) during treatment. Temperate-water immersion (TWI; 21°C) may be an effective alternative to CWI if resources for the latter (eg, ice) are unavailable. OBJECTIVE:   To measure rectal temperature (Trec) cooling rates, thermal sensation, and Environmental Symptoms Questionnaire (ESQ) scores of participants wearing PADS or shorts, undergarments, and socks (NOpads) before, during, and after TWI...
August 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28684590/heat-acclimation-has-a-protective-effect-on-the-central-but-not-peripheral-nervous-system
#11
Sebastien Racinais, Mathew G Wilson, Nadia Gaoua, Julien D Périard
This study aimed to clarify the pathway mediating hyperthermia-induced alterations in neural drive transmission, and determine if heat acclimation protects voluntary muscle activation and cognitive function in hyperthermic humans. Electrically evoked potentials (H-reflex and M-wave), executive function (special planning and working memory) and maximal voluntary isometric contractions (120 s) were assessed in fourteen participants in control condition (CON, 24ºC, 40% RH) and hyperthermic states (HYP, 44-50ºC, 50% RH), on consecutive days in a counterbalanced order...
July 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28621669/human-monocyte-derived-dendritic-cells-exposed-to-hyperthermia-show-a-distinct-gene-expression-profile-and-selective-upregulation-of-igfbp6
#12
Arcangelo Liso, Stefano Castellani, Francesca Massenzio, Rosa Trotta, Alessandra Pucciarini, Barbara Bigerna, Pasquale De Luca, Pietro Zoppoli, Filippo Castiglione, Maria Concetta Palumbo, Fabrizio Stracci, Matteo Landriscina, Giorgina Specchia, Leon A Bach, Massimo Conese, Brunangelo Falini
Fever plays a role in activating innate immunity while its relevance in activating adaptive immunity is less clear. Even brief exposure to elevated temperatures significantly impacts on the immunostimulatory capacity of dendritic cells (DCs), but the consequences on immune response remain unclear. To address this issue, we analyzed the gene expression profiles of normal human monocyte-derived DCs from nine healthy adults subjected either to fever-like thermal conditions (39°C) or to normal temperature (37°C) for 180 minutes...
June 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28607791/benign-multicystic-peritoneal-mesothelioma-a-rare-condition-in-an-uncommon-gender
#13
Muhammad S Khurram, Hamadullah Shaikh, Uqba Khan, Jacob Edens, Warda Ibrar, Ameer Hamza, Awais Zaka, Roohi Bano, Tarik Hadid
Benign Multicystic Peritoneal Mesothelioma (BMPM) is a rare condition that arises from the abdominal peritoneum. Fewer than 200 cases have been reported worldwide. BMPM usually affects premenopausal women and is extremely rare in men. Many factors are suspected to contribute to its development, such as previous surgery, endometriosis, and familial Mediterranean fever. The main management is surgical resection; however, it is estimated that the recurrence rate is up to 50%. Malignant transformation is rare. We report a case series of three male patients who were diagnosed with BMPM and were treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC)...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28601505/heat-and-chemical-treatments-in-adult-cyprinus-carpio-pisces-cypriniformes-rapidly-produce-sterile-gonads
#14
Sullip Kumar Majhi, Avinash Rambhau Rasal, Basdeo Kushwaha, Sudhir Raizada
Several options have been proposed for eradication of germ cells (GCs) in mammals such as treatment with cytotoxic drugs, irradiation, cold ischemia and hyperthermic treatment. Some of these methods have been also tried in fish but conditions for complete sterilisation of gonads have not been established. Here, we report the production of sterile adult common carp Cyprinus carpio in 10 weeks by the heat and chemical treatments. The cytotoxic drug busulfan (40mg/kg) was intraperitoneally injected into the animals at 2-week intervals (5 doses in total), and they were maintained in water at 38°C between Weeks 1 and 10...
June 3, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28601307/hyperthermic-isolated-limb-perfusion-the-switch-from-steinmann-pins-to-omni-tract-assisted-isolation
#15
COMPARATIVE STUDY
Dimitrios Stamatiou, Christos V Ioannou, Nikolaos Kontopodis, Dimosthenis Michelakis, Konstantinos Perisinakis, Konstantinos Lasithiotakis, Odysseas Zoras
BACKGROUND: Hyperthermic isolated limb perfusion (HILP) represents an alternative to amputation for patients with either in-transit melanoma or unresectable soft tissue sarcoma, entailing delivery of high-dose chemotherapy after isolation of the extremity, under hyperthermic conditions. Stabilization of the Esmarch elastic bandage is so far performed with the use of Steinmann pins. In this study, we presented our experience with HILP and demonstrated an alternative technique for limb isolation using an Omni-tract retractor instead of the traditional Steinmann pin, while comparing the two methods...
June 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28593192/intravenous-heroin-induces-rapid-brain-hypoxia-and-hyperglycemia-that-precede-brain-metabolic-response
#16
Ernesto Solis, Keaton T Cameron-Burr, Yavin Shaham, Eugene A Kiyatkin
Heroin use and overdose have increased in recent years as people transition from abusing prescription opiates to using the cheaper street drug. Despite a long history of research, many physiological effects of heroin and their underlying mechanisms remain unknown. Here, we used high-speed amperometry to examine the effects of intravenous heroin on oxygen and glucose levels in the nucleus accumbens (NAc) in freely-moving rats. Heroin within the dose range of human drug use and rat self-administration (100-200 μg/kg) induced a rapid, strong, but transient drop in NAc oxygen that was followed by a slower and more prolonged rise in glucose...
May 2017: ENeuro
https://www.readbyqxmd.com/read/28366987/amplification-of-glutathione-mediated-oxidative-stress-by-catalase-in-an-aqueous-solution-at-hyperthermal-temperatures
#17
Megumi Ueno, Emiko Sekine-Suzuki, Minako Nyui, Ikuo Nakanishi, Ken-Ichiro Matsumoto
The glutathione (GSH)-mediated superoxide (O2(•-)) generation in an aqueous solution and relation of hydrogen peroxide (H2O2) and effect of catalase were investigated. GSH-induced O2(•-) generation in hyperthermal temperatures was measured by the nitroblue tetrazolium (NBT) mehod. Heating an aqueous solution containing GSH caused superoxide from dissolved O2. H2O2 was generated simultaneously in this reaction mixture probably from the hydroperoxy radical (HO2(•)), which is equilibrated with O2(•-) in an aqueous condition, and then H2O2 consumed O2(•-)...
March 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/28351399/effects-of-hyperthermic-baths-on-depression-sleep-and-heart-rate-variability-in-patients-with-depressive-disorder-a-randomized-clinical-pilot-trial
#18
RANDOMIZED CONTROLLED TRIAL
Johannes Naumann, Julian Grebe, Sonja Kaifel, Tomas Weinert, Catharina Sadaghiani, Roman Huber
BACKGROUND: Despite advances in the treatment of depression, one-third of depressed patients fail to respond to conventional antidepressant medication. There is a need for more effective treatments with fewer side effects. The primary aim of this study was to determine whether hyperthermic baths reduce depressive symptoms in adults with depressive disorder. METHODS: Randomized, two-arm placebo-controlled, 8-week pilot trial. Medically stable outpatients with confirmed depressive disorder (ICD-10: F32/F33) who were moderately depressed as determined by the 17-item Hamilton Scale for Depression (HAM-D) score ≥18 were randomly assigned to 2 hyperthermic baths (40 °C) per week for 4 weeks or a sham intervention with green light and follow-up after 4 weeks...
March 28, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28343583/indirect-hand-and-forearm-vasomotion-regional-variations-in-cutaneous-thermosensitivity-during-normothermia-and-mild-hyperthermia
#19
Catriona A Burdon, Kyoko Tagami, Joonhee Park, Joanne N Caldwell, Nigel A S Taylor
In this experiment, hand and forearm vasomotor activity was investigated during localised, but stable heating and cooling of the face, hand and thigh, under open-loop (clamped) conditions. It was hypothesised that facial stimulation would provoke the most potent vascular changes. Nine individuals participated in two normothermic trials (mean body temperature clamp: 36.6°C; water-perfused suit and climate chamber) and two mildly hyperthermic trials (37.9°C). Localised heating (+5°C) and cooling (-5°C) stimuli were applied to equal surface areas of the face, hand and thigh (perfusion patches: 15min), while contralateral forearm or hand blood flows (venous-occlusion plethysmography) were measured (separate trials)...
April 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28319750/unfavorable-effect-of-levetiracetam-on-cultured-hippocampal-neurons-after-hyperthermic-injury
#20
Krzysztof Sendrowski, Piotr Sobaniec, Elżbieta Poskrobko, Małgorzata Rusak, Wojciech Sobaniec
BACKGROUND: The aim of this study was to examine the viability of neurons and the putative neuroprotective effects of second-generation antiepileptic drug, levetiracetam (LEV), on cultured hippocampal neurons injured by hyperthermia. METHODS: Primary cultures of rat's hippocampal neurons at 7day in vitro (DIV) were incubated in the presence or absence of LEV in varied concentrations under hyperthermic conditions. Cultures were heated in a temperature of 40°C for 24h or in a temperature of 41°C for 6h...
June 2017: Pharmacological Reports: PR
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