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Hyperthermic conditioning

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https://www.readbyqxmd.com/read/28202230/intergenerational-transmission-of-enhanced-seizure-susceptibility-after-febrile-seizures
#1
Dengchang Wu, Bo Feng, Yunjian Dai, Xiaohua Wu, Bin Chen, Cenglin Xu, Yangshun Tang, Kang Wang, Shihong Zhang, Shuang Wang, Benyan Luo, Zhong Chen
Environmental exposure early in development plays a role in susceptibility to disease in later life. Here, we demonstrate that prolonged febrile seizures induced by exposure of rat pups to a hyperthermic environment enhance seizure susceptibility not only in these hyperthermia-treated rats but also in their future offspring, even if the offspring never experience febrile seizures. This transgenerational transmission was intensity-dependent and was mainly from mothers to their offspring. The transmission was associated with DNA methylation...
February 8, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28178820/preface-special-topic-on-atomic-and-molecular-layer-processing-deposition-patterning-and-etching
#2
James R Engstrom, Andrew C Kummel
Thin film processing technologies that promise atomic and molecular scale control have received increasing interest in the past several years, as traditional methods for fabrication begin to reach their fundamental limits. Many of these technologies involve at their heart phenomena occurring at or near surfaces, including adsorption, gas-surface reactions, diffusion, desorption, and re-organization of near-surface layers. Moreover many of these phenomena involve not just reactions occurring under conditions of local thermodynamic equilibrium but also the action of energetic species including electrons, ions, and hyperthermal neutrals...
February 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28168311/impact-of-laparotomy-and-intraperitoneal-hyperthermic-instillation-lihi-on-the-oxaliplatin-pharmacokinetics-after-intravenous-administration-in-wistar-rats
#3
María Isabel Mas-Fuster, Amelia Ramon-Lopez, Javier Lacueva, Antonio Compañ, Patricio Más-Serrano, Ricardo Nalda-Molina
PURPOSE: In peritoneal metastasis condition, the fact that most of the disease is limited to the peritoneal cavity laid the foundations for a surgical treatment, including intraperitoneal hyperthermic chemotherapy (HIPEC). The aim of this study was to evaluate the impact of the surgical procedures implied in open HIPEC technique, referred to laparotomy procedures followed by an intraperitoneal hyperthermic instillation (LIHI) on oxaliplatin tissue distribution and elimination. To delimit the influence of this procedure alone, oxaliplatin was administered as an intravenous (iv) bolus in both groups...
February 6, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28162872/simple-and-effective-method-to-lower-body-core-temperatures-of-hyperthermic-patients
#4
John P O'Connor
Hyperthermia is a potentially life threatening scenario that may occur in patients due to accompanying morbidities, exertion, or exposure to dry and arid environmental conditions. In particular, heat stroke may result from environmental exposure combined with a lack of thermoregulation. Key clinical findings in the diagnosis of heatstroke are (1) a history of heat stress or exposure, (2) a rectal temperature greater than 40 °C, and (3) central nervous system dysfunction (altered mental state, disorientation, stupor, seizures, or coma) (Prendergast and Erickson, 2014 [1])...
January 30, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28108645/whole-body-hyperthermia-but-not-skin-hyperthermia-accelerates-brain-and-locomotor-limb-circulatory-strain-and-impairs-exercise-capacity-in-humans
#5
Steven J Trangmar, Scott T Chiesa, Kameljit K Kalsi, Niels H Secher, José González-Alonso
Cardiovascular strain and hyperthermia are thought to be important factors limiting exercise capacity in heat-stressed humans, however, the contribution of elevations in skin (Tsk) versus whole body temperatures on exercise capacity has not been characterized. To ascertain their relationships with exercise capacity, blood temperature (TB), oxygen uptake (V̇O2), brain perfusion (MCA Vmean), locomotor limb hemodynamics, and hematological parameters were assessed during incremental cycling exercise with elevated skin (mild hyperthermia; HYPmild), combined core and skin temperatures (moderate hyperthermia; HYPmod), and under control conditions...
January 2017: Physiological Reports
https://www.readbyqxmd.com/read/28059418/highly-versatile-spion-encapsulated-plga-nanoparticles-as-photothermal-ablators-of-cancer-cells-and-as-multimodal-imaging-agents
#6
Balasubramanian Sivakumar, Ravindran Girija Aswathy, Rebeca Romero-Aburto, Trevor Mitcham, Keith A Mitchel, Yutaka Nagaoka, Richard R Bouchard, Pulickel M Ajayan, Toru Maekawa, Dasappan Nair Sakthikumar
We have designed versatile polymeric nanoparticles with cancer cell specific targeting capabilities via aptamer conjugation after the successful encapsulation of curcumin and superparamagnetic iron oxide nanoparticles (SPIONs) inside a PLGA nanocapsule. These targeted nanocomposites were selectively taken up by tumor cells, under in vitro conditions, demonstrating the effectiveness of the aptamer targeting mechanism. Moreover, the nanocomposite potentially functioned as efficient multiprobes for optical, magnetic resonance imaging (MRI) and photoacoustic imaging contrast agents in the field of cancer diagnostics...
January 6, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28033247/outcomes-of-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-colorectal-cancer-with-peritoneal-metastasis
#7
En-Kwang Lin, Mao-Chih Hsieh, Chien-Hsin Chen, Yen-Jung Lu, Szu-Yuan Wu
In Taiwan, colorectal cancer with peritoneal carcinomatosis is considered a terminal condition. We examined the clinical outcomes of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) treatment for colorectal cancer with peritoneal carcinomatosis in Taiwan.We enrolled patients with colorectal cancer and peritoneal metastasis from Taipei Medical University, Wanfang Hospital between January 1999 and December 2014. Of the enrolled patients, 3 had mucinous-type tumors. In total, we enrolled 31 patients who underwent a total of 33 procedures...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27960434/resistance-of-poss-polyimide-blends-to-hyperthermal-atomic-oxygen-attack
#8
Min Qian, Vanessa J Murray, Wei Wei, Brooks C Marshall, Timothy K Minton
Copolymers of polyhedral oligomeric silsesquioxane (POSS) and polyimide (PI) have shown remarkable resistance to atomic oxygen (AO) attack and have been proposed as replacements for Kapton on the external surfaces of spacecraft in the harsh oxidizing environment of low Earth orbit (LEO). POSS PI blends would be an economical alternative to the copolymers if they also resisted AO attack. Thus, blends of trisilanolphenyl (TSP) POSS and PI with different weight percentages of the Si7O9 POSS cage were cast into films and exposed to a hyperthermal AO beam, and they were characterized in terms of their recession, mass loss, surface morphology, and surface chemistry...
December 14, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27920896/assessing-the-hyperthermic-properties-of-magnetic-heterostructures-the-case-of-gold-iron-oxide-composites
#9
Elvira Fantechi, Paula M Castillo, Erika Conca, Francesca Cugia, Claudio Sangregorio, Maria Francesca Casula
Gold-iron oxide composites were obtained by in situ reduction of an Au(III) precursor by an organic reductant (either potassium citrate or tiopronin) in a dispersion of preformed iron oxide ultrasmall magnetic (USM) nanoparticles. X-ray diffraction, transmission electron microscopy, chemical analysis and mid-infrared spectroscopy show the successful deposition of gold domains on the preformed magnetic nanoparticles, and the occurrence of either citrate or tiopronin as surface coating. The potential of the USM@Au nanoheterostructures as heat mediators for therapy through magnetic fluid hyperthermia was determined by calorimetric measurements under sample irradiation by an alternating magnetic field with intensity and frequency within the safe values for biomedical use...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27903515/passive-heat-acclimation-improves-skeletal-muscle-contractility-in-humans
#10
Sebastien Racinais, Mathew G Wilson, Julien D Périard
The aim of this study was to investigate the effect of repeated passive heat exposure (i.e. acclimation) on muscle contractility in humans. Fourteen non-heat acclimated males completed two trials including electrically evoked twitches and voluntary contractions in thermoneutral conditions (COOL: 24ºC, 40% RH) and hot ambient conditions in the hyperthermic state (HOT: 44-50ºC, 50% RH) on consecutive days in a counterbalanced order. Rectal temperature was ~36.5ºC in COOL and was maintained at ~39ºC throughout HOT...
November 30, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27892715/incorporation-of-chemotherapeutic-agent-and-photosensitizer-in-a-low-temperature-sensitive-liposome-for-effective-chemo-hyperthermic-anticancer-activity
#11
Hanh Thuy Nguyen, Tuan Hiep Tran, Raj Kumar Thapa, Tung Thanh Pham, Jee-Heon Jeong, Yu Seok Youn, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
OBJECTIVES: In this study, we combined chemo- and hyperthermia therapy in a low temperature-sensitive liposome (LTSL) for potential cancer treatment. METHODS: Docetaxel (DOC) and indocyanine green (ICG) as a therapeutic agent and photosensitizer, respectively, were incorporated in a low temperature-sensitive liposome (LTSL/DI). Nanoparticles were evaluated for the physicochemical characterizations, in vitro uptake and cytotoxicity, and furthermore in vivo anticancer activity...
December 7, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27865532/tarp-assisted-cooling-as-a-method-of-whole-body-cooling-in-hyperthermic-individuals
#12
Yuri Hosokawa, William M Adams, Luke N Belval, Lesley W Vandermark, Douglas J Casa
STUDY OBJECTIVE: We investigated the efficacy of tarp-assisted cooling as a body cooling modality. METHODS: Participants exercised on a motorized treadmill in hot conditions (ambient temperature 39.5°C [103.1°F], SD 3.1°C [5.58°F]; relative humidity 38.1% [SD 6.7%]) until they reached exercise-induced hyperthermia. After exercise, participants were cooled with either partial immersion using a tarp-assisted cooling method (water temperature 9.20°C [48.56°F], SD 2...
November 16, 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27812726/avian-thermoregulation-in-the-heat-efficient-evaporative-cooling-in-two-southern-african-nightjars
#13
Ryan S O'Connor, Blair O Wolf, R Mark Brigham, Andrew E McKechnie
Nightjars represent a model taxon for investigating physiological limits of heat tolerance because of their habit of roosting and nesting in sunlit sites during the heat of the day. We investigated the physiological responses of Rufous-cheeked nightjars (Caprimulgus rufigena) and Freckled nightjars (Caprimulgus tristigma) to high air temperatures (T a) by measuring body temperature (T b), resting metabolic rate (RMR) and total evaporative water loss (TEWL) at T a ranging from 10 to 56 °C. Both species became hyperthermic at T a > T b...
November 3, 2016: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/27779544/hyperthermic-intraperitoneal-perfusion-chemotherapy-and-cytoreductive-surgery-for-controlling-malignant-ascites-from-ovarian-cancer
#14
Mingchen Ba, Hui Long, Xiangliang Zhang, Yunqiang Tang, Yinbing Wu, Shuai Wang, Zhaofei Yan, Bohuo Zhang, Shuzhong Cui
BACKGROUND: Malignant ascites, a complication often seen in patients with ovarian cancer (OC), is difficult to treat, but hyperthermic intraperitoneal chemotherapy (HIPEC) has a good efficacy. OBJECTIVE: The aim of this study was to assess the efficacy of cytoreductive surgery (CRS) combined with HIPEC for controlling malignant ascites from OC. MATERIALS AND METHODS: From December 2009 until December 2014, 53 patients with OC and malignant ascites were treated with CRS and HIPEC...
November 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27686583/high-intensity-focused-ultrasound-hyperthermia-for-enhanced-macromolecular-delivery
#15
Nick Frazier, Allison Payne, Joshua de Bever, Christopher Dillon, Apoorva Panda, Nithya Subrahmanyam, Hamidreza Ghandehari
Mild hyperthermia has been used in combination with polymer therapeutics to further increase delivery to solid tumors and enhance efficacy. An attractive method for generating heat is through non-invasive high intensity focused ultrasound (HIFU). HIFU is often used for ablative therapies and must be adapted to produce uniform mild hyperthermia in a solid tumor. In this work a magnetic resonance imaging guided HIFU (MRgHIFU) controlled feedback system was developed to produce a spatially uniform 43°C heating pattern in a subcutaneous mouse tumor...
November 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27682610/hyperthermic-intraperitoneal-chemotherapy-as-palliative-treatment-for-malignant-ascites-a-single-center-experience-and-a-review-of-the-literature
#16
Luigina Graziosi, Elisabetta Marino, Verena De Angelis, Alberto Rebonato, Annibale Donini
: Malignant ascites is an abnormal accumulation of fluid in the peritoneal cavity of patients with intraperitoneal cancer dissemination. This clinical condition could represent the terminal evolution of a lethal disease and could influence the prognosis, severely impairing the patients' quality of life. Treatment options include a multitude of different procedures with limited efficacy and some degree of risk; diuretics, paracentesis, peritoneo-venous shunts and intraperitoneal biologic agents like anti-VEGF molecules, metalloproteinase inhibitors and immunomodulators are included...
2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27677782/mdma-methylone-and-mdpv-drug-induced-brain-hyperthermia-and-its-modulation-by-activity-state-and-environment
#17
Eugene A Kiyatkin, Suelynn E Ren
Psychomotor stimulants are frequently used by humans to intensify the subjective experience of different types of social interactions. Since psychomotor stimulants enhance metabolism and increase body temperatures, their use under conditions of physiological activation and in warm humid environments could result in pathological hyperthermia, a life-threatening symptom of acute drug intoxication. Here, we will describe the brain hyperthermic effects of MDMA, MDPV, and methylone, three structurally related recreational drugs commonly used by young adults during raves and other forms of social gatherings...
September 28, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27570426/chinese-expert-consensus-on-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-peritoneal-malignancies
#18
REVIEW
Yan Li, Yun-Feng Zhou, Han Liang, Hua-Qing Wang, Ji-Hui Hao, Zheng-Gang Zhu, De-Seng Wan, Lun-Xiu Qin, Shu-Zhong Cui, Jia-Fu Ji, Hui-Mian Xu, Shao-Zhong Wei, Hong-Bin Xu, Tao Suo, Shu-Jun Yang, Cong-Hua Xie, Xiao-Jun Yang, Guo-Liang Yang
Locoregional spread of abdominopelvic malignant tumors frequently results in peritoneal carcinomatosis (PC). The prognosis of PC patients treated by conventional systemic chemotherapy is poor, with a median survival of < 6 mo. However, over the past three decades, an integrated treatment strategy of cytoreductive surgery (CRS) + hyperthermic intraperitoneal chemotherapy (HIPEC) has been developed by the pioneering oncologists, with proved efficacy and safety in selected patients. Supported by several lines of clinical evidence from phases I, II and III clinical trials, CRS + HIPEC has been regarded as the standard treatment for selected patients with PC in many established cancer centers worldwide...
August 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27530369/heat-stress-has-an-effect-on-motility-and-metabolic-activity-of-rabbit-spermatozoa
#19
Maria Sabés-Alsina, Oriol Tallo-Parra, Maria Teresa Mogas, Jane M Morrell, Manel Lopez-Bejar
In the warm months the function of the spermatozoa can be affected by the temperature of the reproductive tract of the female exposed to hyperthermic conditions. The aim of this study was to evaluate the impact of heat stress on sperm parameters in an in vitro model and to determine if there were seasonal effects on sperm heat tolerance. Sperm samples from 32 New Zealand White rabbits were collected in two seasons and incubated at scrotal (32.5°C), body (37°C) or hyperthermic (42°C) temperatures for 3h. Sperm viability and morphology were evaluated using nigrosin-eosin staining...
October 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27497343/challenging-the-dogma-of-colorectal-peritoneal-metastases-as-an-untreatable-condition-results-of-a-population-based-study
#20
Lieke G E M Razenberg, Valery E P P Lemmens, Victor J Verwaal, Cornelis J A Punt, Pieter J Tanis, Geert-Jan Creemers, Ignace H J T de Hingh
PURPOSE: To determine the impact of the implementation of novel systemic regimens and locoregional treatment modalities on survival at population level in colorectal cancer (CRC) patients presenting with peritoneal metastases (PMs). METHODS: All consecutive CRC patients with synchronous PM (<3 months) between 1995 and 2014 were extracted from the Eindhoven area of the Netherlands Cancer Registry. Trends in treatment and overall survival were assessed in four time periods...
September 2016: European Journal of Cancer
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