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https://www.readbyqxmd.com/read/27920896/assessing-the-hyperthermic-properties-of-magnetic-heterostructures-the-case-of-gold-iron-oxide-composites
#1
Elvira Fantechi, Paula M Castillo, Erika Conca, Francesca Cugia, Claudio Sangregorio, Maria Francesca Casula
Gold-iron oxide composites were obtained by in situ reduction of an Au(III) precursor by an organic reductant (either potassium citrate or tiopronin) in a dispersion of preformed iron oxide ultrasmall magnetic (USM) nanoparticles. X-ray diffraction, transmission electron microscopy, chemical analysis and mid-infrared spectroscopy show the successful deposition of gold domains on the preformed magnetic nanoparticles, and the occurrence of either citrate or tiopronin as surface coating. The potential of the USM@Au nanoheterostructures as heat mediators for therapy through magnetic fluid hyperthermia was determined by calorimetric measurements under sample irradiation by an alternating magnetic field with intensity and frequency within the safe values for biomedical use...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27903515/passive-heat-acclimation-improves-skeletal-muscle-contractility-in-humans
#2
Sebastien Racinais, Mathew G Wilson, Julien D Périard
The aim of this study was to investigate the effect of repeated passive heat exposure (i.e. acclimation) on muscle contractility in humans. Fourteen non-heat acclimated males completed two trials including electrically evoked twitches and voluntary contractions in thermoneutral conditions (COOL: 24ºC, 40% RH) and hot ambient conditions in the hyperthermic state (HOT: 44-50ºC, 50% RH) on consecutive days in a counterbalanced order. Rectal temperature was ~36.5ºC in COOL and was maintained at ~39ºC throughout HOT...
November 30, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27892715/incorporation-of-chemotherapeutic-agent-and-photosensitizer-in-a-low-temperature-sensitive-liposome-for-effective-chemo-hyperthermic-anticancer-activity
#3
Hanh Thuy Nguyen, Tuan Hiep Tran, Raj Kumar Thapa, Tung Thanh Pham, Jee-Heon Jeong, Yu Seok Youn, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
OBJECTIVES: In this study, we combined chemo- and hyperthermia therapy in a low temperature-sensitive liposome (LTSL) for potential cancer treatment. METHODS: Docetaxel (DOC) and indocyanine green (ICG) as a therapeutic agent and photosensitizer, respectively, were incorporated in a low temperature-sensitive liposome (LTSL/DI). Nanoparticles were evaluated for the physicochemical characterizations, in vitro uptake and cytotoxicity, and furthermore in vivo anticancer activity...
November 28, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27865532/tarp-assisted-cooling-as-a-method-of-whole-body-cooling-in-hyperthermic-individuals
#4
Yuri Hosokawa, William M Adams, Luke N Belval, Lesley W Vandermark, Douglas J Casa
STUDY OBJECTIVE: We investigated the efficacy of tarp-assisted cooling as a body cooling modality. METHODS: Participants exercised on a motorized treadmill in hot conditions (ambient temperature 39.5°C [103.1°F], SD 3.1°C [37.58°F]; relative humidity 38.1% [SD 6.7%]) until they reached exercise-induced hyperthermia. After exercise, participants were cooled with either partial immersion by the tarp-assisted cooling method (water temperature 9.20°C [48.56°F], SD 2...
November 4, 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27812726/avian-thermoregulation-in-the-heat-efficient-evaporative-cooling-in-two-southern-african-nightjars
#5
Ryan S O'Connor, Blair O Wolf, R Mark Brigham, Andrew E McKechnie
Nightjars represent a model taxon for investigating physiological limits of heat tolerance because of their habit of roosting and nesting in sunlit sites during the heat of the day. We investigated the physiological responses of Rufous-cheeked nightjars (Caprimulgus rufigena) and Freckled nightjars (Caprimulgus tristigma) to high air temperatures (T a) by measuring body temperature (T b), resting metabolic rate (RMR) and total evaporative water loss (TEWL) at T a ranging from 10 to 56 °C. Both species became hyperthermic at T a > T b...
November 3, 2016: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/27779544/hyperthermic-intraperitoneal-perfusion-chemotherapy-and-cytoreductive-surgery-for-controlling-malignant-ascites-from-ovarian-cancer
#6
Mingchen Ba, Hui Long, Xiangliang Zhang, Yunqiang Tang, Yinbing Wu, Shuai Wang, Zhaofei Yan, Bohuo Zhang, Shuzhong Cui
BACKGROUND: Malignant ascites, a complication often seen in patients with ovarian cancer (OC), is difficult to treat, but hyperthermic intraperitoneal chemotherapy (HIPEC) has a good efficacy. OBJECTIVE: The aim of this study was to assess the efficacy of cytoreductive surgery (CRS) combined with HIPEC for controlling malignant ascites from OC. MATERIALS AND METHODS: From December 2009 until December 2014, 53 patients with OC and malignant ascites were treated with CRS and HIPEC...
November 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27686583/high-intensity-focused-ultrasound-hyperthermia-for-enhanced-macromolecular-delivery
#7
Nick Frazier, Allison Payne, Joshua de Bever, Christopher Dillon, Apoorva Panda, Nithya Subrahmanyam, Hamidreza Ghandehari
Mild hyperthermia has been used in combination with polymer therapeutics to further increase delivery to solid tumors and enhance efficacy. An attractive method for generating heat is through non-invasive high intensity focused ultrasound (HIFU). HIFU is often used for ablative therapies and must be adapted to produce uniform mild hyperthermia in a solid tumor. In this work a magnetic resonance imaging guided HIFU (MRgHIFU) controlled feedback system was developed to produce a spatially uniform 43°C heating pattern in a subcutaneous mouse tumor...
November 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27682610/hyperthermic-intraperitoneal-chemotherapy-as-palliative-treatment-for-malignant-ascites-a-single-center-experience-and-a-review-of-the-literature
#8
Luigina Graziosi, Elisabetta Marino, Verena De Angelis, Alberto Rebonato, Annibale Donini
: Malignant ascites is an abnormal accumulation of fluid in the peritoneal cavity of patients with intraperitoneal cancer dissemination. This clinical condition could represent the terminal evolution of a lethal disease and could influence the prognosis, severely impairing the patients' quality of life. Treatment options include a multitude of different procedures with limited efficacy and some degree of risk; diuretics, paracentesis, peritoneo-venous shunts and intraperitoneal biologic agents like anti-VEGF molecules, metalloproteinase inhibitors and immunomodulators are included...
2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27677782/mdma-methylone-and-mdpv-drug-induced-brain-hyperthermia-and-its-modulation-by-activity-state-and-environment
#9
Eugene A Kiyatkin, Suelynn E Ren
Psychomotor stimulants are frequently used by humans to intensify the subjective experience of different types of social interactions. Since psychomotor stimulants enhance metabolism and increase body temperatures, their use under conditions of physiological activation and in warm humid environments could result in pathological hyperthermia, a life-threatening symptom of acute drug intoxication. Here, we will describe the brain hyperthermic effects of MDMA, MDPV, and methylone, three structurally related recreational drugs commonly used by young adults during raves and other forms of social gatherings...
September 28, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27570426/chinese-expert-consensus-on-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-peritoneal-malignancies
#10
REVIEW
Yan Li, Yun-Feng Zhou, Han Liang, Hua-Qing Wang, Ji-Hui Hao, Zheng-Gang Zhu, De-Seng Wan, Lun-Xiu Qin, Shu-Zhong Cui, Jia-Fu Ji, Hui-Mian Xu, Shao-Zhong Wei, Hong-Bin Xu, Tao Suo, Shu-Jun Yang, Cong-Hua Xie, Xiao-Jun Yang, Guo-Liang Yang
Locoregional spread of abdominopelvic malignant tumors frequently results in peritoneal carcinomatosis (PC). The prognosis of PC patients treated by conventional systemic chemotherapy is poor, with a median survival of < 6 mo. However, over the past three decades, an integrated treatment strategy of cytoreductive surgery (CRS) + hyperthermic intraperitoneal chemotherapy (HIPEC) has been developed by the pioneering oncologists, with proved efficacy and safety in selected patients. Supported by several lines of clinical evidence from phases I, II and III clinical trials, CRS + HIPEC has been regarded as the standard treatment for selected patients with PC in many established cancer centers worldwide...
August 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27530369/heat-stress-has-an-effect-on-motility-and-metabolic-activity-of-rabbit-spermatozoa
#11
Maria Sabés-Alsina, Oriol Tallo-Parra, Maria Teresa Mogas, Jane M Morrell, Manel Lopez-Bejar
In the warm months the function of the spermatozoa can be affected by the temperature of the reproductive tract of the female exposed to hyperthermic conditions. The aim of this study was to evaluate the impact of heat stress on sperm parameters in an in vitro model and to determine if there were seasonal effects on sperm heat tolerance. Sperm samples from 32 New Zealand White rabbits were collected in two seasons and incubated at scrotal (32.5°C), body (37°C) or hyperthermic (42°C) temperatures for 3h. Sperm viability and morphology were evaluated using nigrosin-eosin staining...
October 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27497343/challenging-the-dogma-of-colorectal-peritoneal-metastases-as-an-untreatable-condition-results-of-a-population-based-study
#12
Lieke G E M Razenberg, Valery E P P Lemmens, Victor J Verwaal, Cornelis J A Punt, Pieter J Tanis, Geert-Jan Creemers, Ignace H J T de Hingh
PURPOSE: To determine the impact of the implementation of novel systemic regimens and locoregional treatment modalities on survival at population level in colorectal cancer (CRC) patients presenting with peritoneal metastases (PMs). METHODS: All consecutive CRC patients with synchronous PM (<3 months) between 1995 and 2014 were extracted from the Eindhoven area of the Netherlands Cancer Registry. Trends in treatment and overall survival were assessed in four time periods...
September 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27450604/effects-of-a-new-cooling-technology-on-physical-performance-in-us-air-force-military-personnel
#13
Reginald O'Hara, Christopher Vojta, Amy Henry, Lydia Caldwell, Molly Wade, Stacie Swanton, Jon K Linderman, Jason Ordway
INTRODUCTION: Heat-related illness is a critical factor for military personnel operating in hyperthermic environments. Heat illness can alter cognitive and physical performance during sustained operations missions. Therefore, the primary purpose of this investigation was to determine the effects of a novel cooling shirt on core body temperature in highly trained US Air Force personnel. METHODS: Twelve trained (at least 80th percentile for aerobic fitness according to the American College of Sports Medicine, at least 90% on the US Air Force fitness test), male Air Force participants (mean values: age, 25 ± 2...
December 0: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/27362668/cytoreductive-surgery-combined-with-hyperthermic-intraperitoneal-chemoperfusion-for-the-treatment-of-gastric-cancer-a-single-centre-retrospective-study
#14
Yinuo Tu, Yunhong Tian, Zhiyuan Fang, Qiang Ruan, Hongsheng Tang, Xiangliang Zhang, Yinbing Wu, Yan Ding, Shuzhong Cui
AIM: Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemoperfusion (HIPEC) is the treatment regime most likely to achieve prolonged survival in patients with peritoneal carcinomatosis from gastroenteric cancer. To date, few publications have focused on the treatment of patients with gastric cancer alone. Several controversies remain unsolved, including the safety and effectiveness of the CRS-HIPEC combination regime, particularly in cases where HIPEC is used as adjuvant treatment after CRS...
September 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27347669/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-the-management-of-gastrointestinal-cancers-with-peritoneal-metastases-progress-toward-a-new-standard-of-care
#15
REVIEW
Paul H Sugarbaker
Peritoneal metastases from gastrointestinal cancer was, in the past, accepted as an inevitable component of the natural history of these diseases. It is a major cause of intestinal obstruction, fistula formation, and bowel perforation as the recurrent malignancy progresses to a terminal condition. Peritoneal metastases may be caused by full thickness penetration of the bowel wall by the primary cancer or by spilled cancer cells released into the peritoneal space by surgical trauma. Two new surgical technologies that have evolved to manage peritoneal metastases are cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)...
July 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27320384/the-safety-and-efficacy-of-thermal-lipolysis-of-adipose-tissue-via-ultrasound-for-circumference-reduction-an-open-label-single-arm-exploratory-study
#16
Morkel J Otto
BACKGROUND AND OBJECTIVE: To better understand adipocyte sensitivity under hyperthermic conditions, the ULTIMA system (also known as MUST) was designed to induce the thermal destruction of fat cells using ultrasound, radiofrequency, and vacuuming. This clinical study assessed the safety and efficacy of ULTIMA in non-invasive reductions of abdominal circumference. STUDY DESIGN: This open-label, single-arm exploratory study monitored the response of 21 patients to a single fat reduction treatment session with the ULTIMA system...
October 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27304927/hyperthermal-intact-molecular-ions-play-key-role-in-retention-of-atrp-surface-initiation-capability-of-plasma-polymer-films-from-ethyl-%C3%AE-bromoisobutyrate
#17
Solmaz Saboohi, Bryan R Coad, Andrew Michelmore, Robert D Short, Hans J Griesser
We report a systematic study of the plasma polymerization of ethyl α-bromoisobutyrate (EBIB) to produce thin film coatings capable of serving as ATRP initiation surfaces, for which they must contain α-bromoisobutyryl functional groups. In the deposition of polymeric coatings by plasma polymerization there generally occurs considerable fragmentation of precursor ("monomer") molecules in the plasma; and the retention of larger structural elements is challenging, particularly when they are inherently chemically labile...
June 29, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27301190/a-novel-combined-approach-of-short-chain-sphingolipids-and-thermosensitive-liposomes-for-improved-drug-delivery-to-tumor-cells
#18
Azadeh Haeri, Lilia R C Pedrosa, Timo L M Ten Hagen, Simin Dadashzadeh, Gerben A Koning
Despite the advantages of liposomal drug delivery, the bioavailability of the chemotherapeutic drugs to tumor cells is limited by their slow release from nanocarriers and low drug permeability across cell membranes. Drug encapsulation into stealth thermosensitive liposomes can improve drug delivery to tumors by combining efficient accumulation at tumors and the active release of the payload following remote heat triggering. Short-chain sphingolipids are known to enhance cellular uptake of amphiphilic drugs...
April 2016: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/27297770/deferoxamine-improves-antioxidative-protection-in-the-brain-of-neonatal-rats-the-role-of-anoxia-and-body-temperature
#19
Hanna Kletkiewicz, Anna Nowakowska, Agnieszka Siejka, Celestyna Mila-Kierzenkowska, Alina Woźniak, Michał Caputa, Justyna Rogalska
After hypoxic-ischemic insult iron deposited in the brain catalyzes formation of reactive oxygen species. Newborn rats, showing reduced physiological body temperature and their hyperthermic counterparts injected with deferoxamine (DF), a chelator of iron, are protected both against iron-mediated neurotoxicity and against depletion of low-molecular antioxidants after perinatal asphyxia. Therefore, we decided to study the effects of DF on activity of antioxidant enzymes (superoxide dismutase-SOD, glutathione peroxidase-GPx and catalase-CAT) in the brain of rats exposed neonatally to a critical anoxia at body temperatures elevated to 39°C...
August 15, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27264884/an-acute-bout-of-whole-body-passive-hyperthermia-increases-plasma-leptin-but-does-not-alter-glucose-or-insulin-responses-in-obese-type-2-diabetics-and-healthy-adults
#20
Eric Rivas, Dan E Newmire, Craig G Crandall, Philip L Hooper, Vic Ben-Ezra
Acute and chronic hyperthermic treatments in diabetic animal models repeatedly improve insulin sensitivity and glycemic control. Therefore, the purpose of this study was to test the hypothesis that an acute 1h bout of hyperthermic treatment improves glucose, insulin, and leptin responses to an oral glucose challenge (OGTT) in obese type 2 diabetics and healthy humans. Nine obese (45±7.1% fat mass) type 2 diabetics (T2DM: 50.1±12y, 7.5±1.8% HbA1c) absent of insulin therapy and nine similar aged (41.1±13...
July 2016: Journal of Thermal Biology
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