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Hyperthermic conditioning

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https://www.readbyqxmd.com/read/29112514/effects-of-intravenous-cold-saline-on-hyperthermic-athletes-representative-of-large-football-players-and-small-endurance-runners
#1
Katherine E Morrison, Natasha Desai, Christopher McGuigan, Megan Lennon, Sandra Fowkes Godek
OBJECTIVE: To evaluate the cooling effects of intravenous (IV) cold normal (0.9%) saline on hyperthermic athletes. DESIGN: Randomized crossover study design. SETTING: Controlled research laboratory. PARTICIPANTS: Twelve male participants who were representative of a collegiate cross-country (6) and American football (6) population. INTERVENTIONS: Participants underwent body composition analysis using a BodPod...
October 27, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29111382/innovative-approach-to-safely-induce-controlled-lipolysis-by-superparamagnetic-iron-oxide-nanoparticles-mediated-hyperthermic-treatment
#2
Maria Rosaria Marinozzi, Laura Pandolfi, Manuela Malatesta, Miriam Colombo, Veronica Collico, Patricia Marie-Jeanne Lievens, Stefano Tambalo, Chiara Lasconi, Federica Vurro, Federico Boschi, Silvia Mannucci, Andrea Sbarbati, Davide Prosperi, Laura Calderan
During last years, evidence has been provided on the involvement of overweight and obesity in the pathogenesis and aggravation of several life-threatening diseases. Here, we demonstrate that, under appropriate administration conditions, polyhedral iron oxide nanoparticles are efficiently and safely taken up by 3T3 cell line-derived adipocytes (3T3 adipocytes) in vitro. Since these nanoparticles proved to effectively produce heat when subjected to alternating magnetic field, 3T3 adipocytes were submitted to superparamagnetic iron oxide nanoparticles-mediated hyperthermia treatment (SMHT), with the aim of modulating their lipid content...
October 27, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29108718/a-new-animal-model-for-hyperthermic-intraperitoneal-chemotherapy-hipec-in-tumor-bearing-mice-in-the-treatment-of-peritoneal-carcinomatosis-of-ovarian-origin
#3
G Miailhe, A Arfi, M Mirshahi, C Eveno, M Pocard, C Touboul
AIM OF THE STUDY: We set out to develop and evaluate the morbidity of a non-invasive hyperthermic intraperitoneal chemotherapy (HIPEC) procedure in mice. HIPEC has been shown to improve overall survival in treating ovarian cancer with peritoneal carcinomatosis. However, related complications, toxicity and the lack of randomized trials limits its widespread use. To improve the surgical technique, there is a need for animal models that allow teams to work on large groups without burdensome logistics...
November 3, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29108477/hyperthermia-and-mild-traumatic-brain-injury-effects-on-inflammation-and-the-cerebral-vasculature
#4
Jessie Truettner, Helen M Bramlett, W Dalton Dietrich
Mild traumatic brain injury (mTBI) or concussion represents the majority of TBIs brain trauma in the United States. The pathophysiology of mTBI is complex and may include both focal and diffuse injury patterns. In addition to altered circuit dysfunction and diffuse traumatic axonal injury (DTAI), chronic neuroinflammation has also been implicated in the pathophysiology of mTBI. Recently, our laboratory has reported the detrimental effects of mild hyperthermic mTBI in terms of worsening histopathological and behavioral outcomes...
November 6, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29089991/effect-of-hyperthermia-on-calbindin-d-28k-immunoreactivity-in-the-hippocampal-formation-following-transient-global-cerebral-ischemia-in-gerbils
#5
Jae-Chul Lee, Jeong-Hwi Cho, Tae-Kyeong Lee, In Hye Kim, Moo-Ho Won, Geum-Sil Cho, Bich-Na Shin, In Koo Hwang, Joon Ha Park, Ji Hyeon Ahn, Il Jun Kang, Young Joo Lee, Yang Hee Kim
Calbindin D-28K (CB), a Ca(2+)-binding protein, maintains Ca(2+) homeostasis and protects neurons against various insults. Hyperthermia can exacerbate brain damage produced by ischemic insults. However, little is reported about the role of CB in the brain under hyperthermic condition during ischemic insults. We investigated the effects of transient global cerebral ischemia on CB immunoreactivity as well as neuronal damage in the hippocampal formation under hyperthermic condition using immunohistochemistry for neuronal nuclei (NeuN) and CB, and Fluoro-Jade B histofluorescence staining in gerbils...
September 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29089784/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-appendiceal-goblet-cell-carcinomas-with-peritoneal-carcinomatosis-results-from-a-single-specialized-center
#6
Hsin-Hsien Yu, Yutaka Yonemura, Mao-Chih Hsieh, Akiyoshi Mizumoto, Satoshi Wakama, Chang-Yun Lu
BACKGROUND: Goblet cell carcinomas (GCCs) of the appendix are rare and aggressive malignancies with early peritoneal dissemination. The aim of the present article is to describe our experience in the management of GCCs with peritoneal carcinomatosis (PC) through cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) and to determine the impact of multiple clinical characteristics on the prognosis. METHODS: From a prospectively maintained database of patients receiving CRS and HIPEC for peritoneal surface malignancy, the data of 15 patients with GCC and PC were collected...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29060699/hyperthermia-dependence-of-cardiac-conduction-velocity-in-rat-myocardium-optical-mapping-and-cardiac-near-field-measurements
#7
Stefan Pollnow, Robert Arnold, Matthias Werber, Olaf Dossel, Gunnar Seemann
Hyperthermia during radiofrequency ablation causes reversible and irreversible changes of the electrophysiological properties of cardiac tissue. However, the mechanisms are incompletely understood. We studied changes of conduction velocity (CV) in rat myocardium under hyperthermic conditions from macroscopic to microscopic scale by using simultaneous optical mapping and a miniaturized electrode array. Atrial preparations from five rats were superfused at tissue bath temperatures between 36.7°C and 43.8°C...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29021627/dispersal-of-thermophilic-beetles-across-the-intercontinental-arctic-forest-belt-during-the-early-eocene
#8
Adam J Brunke, Stylianos Chatzimanolis, Brian D Metscher, Karin Wolf-Schwenninger, Alexey Solodovnikov
Massive biotic change occurred during the Eocene as the climate shifted from warm and equable to seasonal and latitudinally stratified. Mild winter temperatures across Arctic intercontinental land bridges permitted dispersal of frost-intolerant groups until the Eocene-Oligocene boundary, while trans-Arctic dispersal in thermophilic groups may have been limited to the early Eocene, especially during short-lived hyperthermals. Some of these lineages are now disjunct between continents of the northern hemisphere...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28992447/magnetic-hyperthermia-efficiency-and-mri-contrast-sensitivity-of-colloidal-soft-hard-ferrite-nanoclusters
#9
Kosmas Vamvakidis, Stefanos Mourdikoudis, Antonis Makridis, Eleni Paulidou, Mavroeidis Angelakeris, Catherine Dendrinou-Samara
The use of magnetic nanostructures as theranostic agents is a multiplex task as physiochemical and biochemical properties including excellent magneto-responsive properties, low toxicity, colloidal stability and facile surface engineering capability are all required. Nonetheless, much progress has been made in recent years synthesis of "all-in-one" MNPs remain unambiguously challenging. Towards this direction, in this study is presented a facile incorporation of a soft magnetic phase (MnFe2O4 NPs) with a hard phase (CoFe2O4 NPs) in the presence of the biocompatible polymer sodium dodecyl sulfate (SDS), into spherical and compact bi-magnetic nanoclusters (NCs) with modulated magnetic properties that critically enhance hyperthermic efficiency and MRI contrast effect...
October 3, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28992254/latitudinal-clines-in-temperature-and-salinity-tolerance-in-tidepool-copepods
#10
Wai Leong, Patrick Y Sun, Suzanne Edmands
Local adaptation has been understudied in marine systems, but might be expected to be pronounced in the tidepool copepod Tigriopus californicus, which has a broad geographic range and extremely restricted dispersal. Tolerance to temperature and salinity was assessed in 14 populations over a 20° latitudinal range. Adaptive differentiation to temperature and salinity was found at scales as low as 5.6 km. Latitudinal clines were significant, with northern populations being more tolerant of low salinity and less tolerant of high temperature and high salinity...
July 18, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28977828/human-monocyte-derived-dendritic-cells-exposed-to-hyperthermia-show-a-distinct-gene-expression-profile-and-selective-upregulation-of-igfbp6
#11
Arcangelo Liso, Stefano Castellani, Francesca Massenzio, Rosa Trotta, Alessandra Pucciarini, Barbara Bigerna, Pasquale De Luca, Pietro Zoppoli, Filippo Castiglione, Maria Concetta Palumbo, Fabrizio Stracci, Matteo Landriscina, Giorgina Specchia, Leon A Bach, Massimo Conese, Brunangelo Falini
Fever plays a role in activating innate immunity while its relevance in activating adaptive immunity is less clear. Even brief exposure to elevated temperatures significantly impacts on the immunostimulatory capacity of dendritic cells (DCs), but the consequences on immune response remain unclear. To address this issue, we analyzed the gene expression profiles of normal human monocyte-derived DCs from nine healthy adults subjected either to fever-like thermal conditions (39°C) or to normal temperature (37°C) for 180 minutes...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976512/enhanced-blood-brain-barrier-permeability-and-glioblastoma-cell-targeting-via-thermoresponsive-lipid-nanoparticles
#12
M Rehman, A Madni, D Shi, A Ihsan, N Tahir, K R Chang, I Javed, T J Webster
Thermoresponsive targeting is used to deliver therapeutic agents at hyperthermic conditions (39-45 °C). However, available thermoresponsive drug delivery systems (TDDS), including liposomes, have a complex method of preparation involving toxic solvents and reagents. The objective of this in vitro study was to prepare and characterize thermoresponsive lipid nanoparticles (TLN) for treating glioblastoma, the most aggressive brain tumor whose treatment is limited by a low blood brain barrier (BBB) permeability of drugs...
October 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28974122/activation-of-hypoxia-inducible-factor-1%C3%AE-in-rat-brain-after-perinatal-anoxia-role-of-body-temperature
#13
Hanna Kletkiewicz, Malwina Hyjek, Krzysztof Jaworski, Anna Nowakowska, Justyna Rogalska
Transcriptional hypoxia-inducible factor-1α (HIF-1α) plays the fundamental role in adaptive processes in response to hypoxia. Specific HIF-1α target genes are involved in glycolysis, erythropoiesis and angiogenesis to promote survival. In our previous study we have demonstrated that naturally low body temperature of newborn rats protects them against damage due to perinatal hypoxia. Therefore, our experiments aimed at checking the effects of body temperature during simulated perinatal anoxia on subsequent changes of expression of HIF-1α and its specific target genes such as vascular endothelial growth factor (VEGF) and erythropoietin (EPO) in the rat brain...
October 23, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28964038/communication-hot-atom-abstraction-dynamics-of-hydrogen-from-tungsten-surfaces-the-role-of-surface-structure
#14
Oihana Galparsoro, Heriberto Fabio Busnengo, Joseba Iñaki Juaristi, Cédric Crespos, Maite Alducin, Pascal Larregaray
Adiabatic and non-adiabatic quasiclassical molecular dynamics simulations are performed to investigate the role of the crystal face on hot-atom abstraction of H adsorbates by H scattering from covered W(100) and W(110). On both cases, hyperthermal diffusion is strongly affected by the energy dissipated into electron-hole pair excitations. As a result, the hot-atom abstraction is highly reduced in favor of adsorption at low incidence energy and low coverages, i.e., when the mean free path of the hyperthermal H is typically larger...
September 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28943248/the-medial-preoptic-area-modulates-autonomic-function-under-resting-and-stress-conditions
#15
Aline Fassini, América A Scopinho, Fernando H F Alves, Eduardo A T Fortaleza, Fernando M A Corrêa
The medial preoptic area (mPOA) participates in the temperature and cardiovascular control. The mPOA receives inputs from limbic structures and sends projections to hypothalamus and brainstem. Moreover, stress elicits pronounced neuronal activation in mPOA, suggesting its involvement in central neural pathway mediating stress responses. In the present study, we report the effect of acute mPOA neurotransmission inhibition using cobalt chloride (CoCl2-nonselective synapse blocker) on the mean arterial pressure (MAP), heart rate (HR), body and tail temperature (Tbody and Ttail, respectively), as well as on the HR component of baroreflex...
November 19, 2017: Neuroscience
https://www.readbyqxmd.com/read/28927330/thalamocortical-neural-responses-during-hyperthermia-a-resting-state-functional-mri-study
#16
Jing Zhang, Shaowen Qian, Qingjun Jiang, Guanzhong Gong, Kai Liu, Bo Li, Yong Yin, Gang Sun
The neural responses during hyperthermia, once thought of as simple physiological processes (e.g. thermal sensation and regulation), have now been recognized involving more cognitive processes, which would be highly of importance to the management of those occupations during heavy heat exposure. Previous studies have demonstrated altered activity in localized subcortical clusters for thermal sensation and regulation, as well as cortical-cortical activity for behavioral tasks during hyperthermia. However, the involvement of cortical-subcortical activity during hyperthermia has not been investigated...
September 19, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28887185/role-of-monoaminergic-systems-and-ambient-temperature-in-bath-salts-constituent-3-4-methylenedioxypyrovalerone-mdpv-elicited-hyperthermia-and-locomotor-stimulation-in-mice
#17
REVIEW
Brenda M Gannon, Adrian Williamson, Kenner C Rice, William E Fantegrossi
3,4-Methylenedioxypyrovalerone (MDPV) is a common constituent of illicit bath salts products, and in vitro studies implicate monoamine transporters as mediators of its pharmacological effects. Locomotor and thermoregulatory effects of MDPV depend on ambient temperature, so the current studies aimed to gauge the involvement of dopamine (DA), norepinephrine (NE), and serotonin (5-HT) in MDPV-induced locomotor stimulation and hyperthermia in the mouse at different ambient temperatures. Mice were pretreated with the selective 5-HT-reuptake inhibitor fluoxetine (3 mg/kg), the NE-reuptake inhibitor desipramine (3 mg/kg), the DA-reuptake inhibitor bupropion (10 mg/kg), or saline, followed by 10 mg/kg MDPV while thermoregulation and locomotor activity were monitored via radiotelemetry...
September 5, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28870927/response-of-ovcar-3-cells-to-cisplatin-and-hyperthermia-does-hyperthermia-really-matter
#18
Arturas Sukovas, Vaidotas Cesna, Aldona Jasukaitiene, Giedrius Barauskas, Ruta Jolanta Nadisauskiene, Zilvinas Dambrauskas, Saulius Paskauskas, Antanas Gulbinas
BACKGROUND: Hyperthermic intraperitoneal chemotherapy (HIPEC) is proposed as a promising treatment method, but fundamental information about the contribution of hyperthermia to intraperitoneal chemotherapy is lacking. The purpose of this study was to investigate the cytotoxic effect of hyperthermia and cisplatin on OVCAR-3 cells in vitro. MATERIALS AND METHODS: Imitating the typical clinical conditions of HIPEC, OVCAR-3 cells were exposed to hyperthermia and cisplatin for 1 h...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28833689/cold-water-immersion-kill-or-cure
#19
M J Tipton, N Collier, H Massey, J Corbett, M Harper
What is the topic of this review? This is the first review to look across the broad field of 'cold water immersion' and to determine the threats and benefits associated with it as both a hazard and a treatment. What advances does it highlight? The level of evidence supporting each of the areas reviewed is assessed. Like other environmental constituents, such as pressure, heat and oxygen, cold water can be either good or bad, threat or treatment, depending on circumstance. Given the current increase in the popularly of open cold water swimming, it is timely to review the various human responses to cold water immersion (CWI) and consider the strength of the claims made for the effects of CWI...
August 23, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28830980/acute-heat-stress-activated-inflammatory-signaling-in-porcine-oxidative-skeletal-muscle
#20
Shanthi Ganesan, Olga Volodina, Sarah C Pearce, Nicholas K Gabler, Lance H Baumgard, Robert P Rhoads, Joshua T Selsby
Despite well-studied clinical manifestations, intracellular mechanisms of prolonged hyperthermic injury remain unclear, especially in skeletal muscle. Given muscle's large potential to impact systemic inflammation and metabolism, the response of muscle cells to heat-mediated injury warrants further investigation. We have previously reported increased activation of NF-κB signaling and increased NF-κB and AP-1-driven transcripts in oxidative skeletal muscle following 12 h of heat stress. The purpose of this investigation was to examine early heat stress-induced inflammatory signaling in skeletal muscle...
August 2017: Physiological Reports
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