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Hyperthermic conditioning

Nick Frazier, Allison Payne, Joshua de Bever, Christopher Dillon, Apoorva Panda, Nithya Subrahmanyam, Hamidreza Ghandehari
Mild hyperthermia has been used in combination with polymer therapeutics to further increase delivery to solid tumors and enhance efficacy. An attractive method for generating heat is through non-invasive high intensity focused ultrasound (HIFU). HIFU is often used for ablative therapies and must be adapted to produce uniform mild hyperthermia in a solid tumor. In this work a magnetic resonance imaging guided HIFU (MRgHIFU) controlled feedback system was developed to produce a spatially uniform 43°C heating pattern in a subcutaneous mouse tumor...
November 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
Luigina Graziosi, Elisabetta Marino, Verena De Angelis, Alberto Rebonato, Annibale Donini
: Malignant ascites is an abnormal accumulation of fluid in the peritoneal cavity of patients with intraperitoneal cancer dissemination. This clinical condition could represent the terminal evolution of a lethal disease and could influence the prognosis, severely impairing the patients' quality of life. Treatment options include a multitude of different procedures with limited efficacy and some degree of risk; diuretics, paracentesis, peritoneo-venous shunts and intraperitoneal biologic agents like anti-VEGF molecules, metalloproteinase inhibitors and immunomodulators are included...
2016: Annali Italiani di Chirurgia
Eugene A Kiyatkin, Suelynn E Ren
Psychomotor stimulants are frequently used by humans to intensify the subjective experience of different types of social interactions. Since psychomotor stimulants enhance metabolism and increase body temperatures, their use under conditions of physiological activation and in warm humid environments could result in pathological hyperthermia, a life-threatening symptom of acute drug intoxication. Here, we will describe the brain hyperthermic effects of MDMA, MDPV, and methylone, three structurally related recreational drugs commonly used by young adults during raves and other forms of social gatherings...
September 28, 2016: Current Topics in Behavioral Neurosciences
Yan Li, Yun-Feng Zhou, Han Liang, Hua-Qing Wang, Ji-Hui Hao, Zheng-Gang Zhu, De-Seng Wan, Lun-Xiu Qin, Shu-Zhong Cui, Jia-Fu Ji, Hui-Mian Xu, Shao-Zhong Wei, Hong-Bin Xu, Tao Suo, Shu-Jun Yang, Cong-Hua Xie, Xiao-Jun Yang, Guo-Liang Yang
Locoregional spread of abdominopelvic malignant tumors frequently results in peritoneal carcinomatosis (PC). The prognosis of PC patients treated by conventional systemic chemotherapy is poor, with a median survival of < 6 mo. However, over the past three decades, an integrated treatment strategy of cytoreductive surgery (CRS) + hyperthermic intraperitoneal chemotherapy (HIPEC) has been developed by the pioneering oncologists, with proved efficacy and safety in selected patients. Supported by several lines of clinical evidence from phases I, II and III clinical trials, CRS + HIPEC has been regarded as the standard treatment for selected patients with PC in many established cancer centers worldwide...
August 14, 2016: World Journal of Gastroenterology: WJG
Maria Sabés-Alsina, Oriol Tallo-Parra, Maria Teresa Mogas, Jane M Morrell, Manel Lopez-Bejar
In the warm months the function of the spermatozoa can be affected by the temperature of the reproductive tract of the female exposed to hyperthermic conditions. The aim of this study was to evaluate the impact of heat stress on sperm parameters in an in vitro model and to determine if there were seasonal effects on sperm heat tolerance. Sperm samples from 32 New Zealand White rabbits were collected in two seasons and incubated at scrotal (32.5°C), body (37°C) or hyperthermic (42°C) temperatures for 3h. Sperm viability and morphology were evaluated using nigrosin-eosin staining...
October 2016: Animal Reproduction Science
Lieke G E M Razenberg, Valery E P P Lemmens, Victor J Verwaal, Cornelis J A Punt, Pieter J Tanis, Geert-Jan Creemers, Ignace H J T de Hingh
PURPOSE: To determine the impact of the implementation of novel systemic regimens and locoregional treatment modalities on survival at population level in colorectal cancer (CRC) patients presenting with peritoneal metastases (PMs). METHODS: All consecutive CRC patients with synchronous PM (<3 months) between 1995 and 2014 were extracted from the Eindhoven area of the Netherlands Cancer Registry. Trends in treatment and overall survival were assessed in four time periods...
September 2016: European Journal of Cancer
Reginald O'Hara, Christopher Vojta, Amy Henry, Lydia Caldwell, Molly Wade, Stacie Swanton, Jon K Linderman, Jason Ordway
INTRODUCTION: Heat-related illness is a critical factor for military personnel operating in hyperthermic environments. Heat illness can alter cognitive and physical performance during sustained operations missions. Therefore, the primary purpose of this investigation was to determine the effects of a novel cooling shirt on core body temperature in highly trained US Air Force personnel. METHODS: Twelve trained (at least 80th percentile for aerobic fitness according to the American College of Sports Medicine, at least 90% on the US Air Force fitness test), male Air Force participants (mean values: age, 25 ± 2...
2016: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Yinuo Tu, Yunhong Tian, Zhiyuan Fang, Qiang Ruan, Hongsheng Tang, Xiangliang Zhang, Yinbing Wu, Yan Ding, Shuzhong Cui
AIM: Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemoperfusion (HIPEC) is the treatment regime most likely to achieve prolonged survival in patients with peritoneal carcinomatosis from gastroenteric cancer. To date, few publications have focused on the treatment of patients with gastric cancer alone. Several controversies remain unsolved, including the safety and effectiveness of the CRS-HIPEC combination regime, particularly in cases where HIPEC is used as adjuvant treatment after CRS...
September 2016: International Journal of Hyperthermia
Paul H Sugarbaker
Peritoneal metastases from gastrointestinal cancer was, in the past, accepted as an inevitable component of the natural history of these diseases. It is a major cause of intestinal obstruction, fistula formation, and bowel perforation as the recurrent malignancy progresses to a terminal condition. Peritoneal metastases may be caused by full thickness penetration of the bowel wall by the primary cancer or by spilled cancer cells released into the peritoneal space by surgical trauma. Two new surgical technologies that have evolved to manage peritoneal metastases are cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)...
July 2016: Cancer Treatment Reviews
Morkel J Otto
BACKGROUND AND OBJECTIVE: To better understand adipocyte sensitivity under hyperthermic conditions, the ULTIMA system (also known as MUST) was designed to induce the thermal destruction of fat cells using ultrasound, radiofrequency, and vacuuming. This clinical study assessed the safety and efficacy of ULTIMA in non-invasive reductions of abdominal circumference. STUDY DESIGN: This open-label, single-arm exploratory study monitored the response of 21 patients to a single fat reduction treatment session with the ULTIMA system...
June 20, 2016: Lasers in Surgery and Medicine
Solmaz Saboohi, Bryan R Coad, Andrew Michelmore, Robert D Short, Hans J Griesser
We report a systematic study of the plasma polymerization of ethyl α-bromoisobutyrate (EBIB) to produce thin film coatings capable of serving as ATRP initiation surfaces, for which they must contain α-bromoisobutyryl functional groups. In the deposition of polymeric coatings by plasma polymerization there generally occurs considerable fragmentation of precursor ("monomer") molecules in the plasma; and the retention of larger structural elements is challenging, particularly when they are inherently chemically labile...
June 29, 2016: ACS Applied Materials & Interfaces
Azadeh Haeri, Lilia R C Pedrosa, Timo L M Ten Hagen, Simin Dadashzadeh, Gerben A Koning
Despite the advantages of liposomal drug delivery, the bioavailability of the chemotherapeutic drugs to tumor cells is limited by their slow release from nanocarriers and low drug permeability across cell membranes. Drug encapsulation into stealth thermosensitive liposomes can improve drug delivery to tumors by combining efficient accumulation at tumors and the active release of the payload following remote heat triggering. Short-chain sphingolipids are known to enhance cellular uptake of amphiphilic drugs...
April 2016: Journal of Biomedical Nanotechnology
Hanna Kletkiewicz, Anna Nowakowska, Agnieszka Siejka, Celestyna Mila-Kierzenkowska, Alina Woźniak, Michał Caputa, Justyna Rogalska
After hypoxic-ischemic insult iron deposited in the brain catalyzes formation of reactive oxygen species. Newborn rats, showing reduced physiological body temperature and their hyperthermic counterparts injected with deferoxamine (DF), a chelator of iron, are protected both against iron-mediated neurotoxicity and against depletion of low-molecular antioxidants after perinatal asphyxia. Therefore, we decided to study the effects of DF on activity of antioxidant enzymes (superoxide dismutase-SOD, glutathione peroxidase-GPx and catalase-CAT) in the brain of rats exposed neonatally to a critical anoxia at body temperatures elevated to 39°C...
August 15, 2016: Neuroscience Letters
Eric Rivas, Dan E Newmire, Craig G Crandall, Philip L Hooper, Vic Ben-Ezra
Acute and chronic hyperthermic treatments in diabetic animal models repeatedly improve insulin sensitivity and glycemic control. Therefore, the purpose of this study was to test the hypothesis that an acute 1h bout of hyperthermic treatment improves glucose, insulin, and leptin responses to an oral glucose challenge (OGTT) in obese type 2 diabetics and healthy humans. Nine obese (45±7.1% fat mass) type 2 diabetics (T2DM: 50.1±12y, 7.5±1.8% HbA1c) absent of insulin therapy and nine similar aged (41.1±13...
July 2016: Journal of Thermal Biology
Takakazu Oka
Psychogenic fever is a stress-related, psychosomatic disease especially seen in young women. Some patients develop extremely high core body temperature (Tc) (up to 41°C) when they are exposed to emotional events, whereas others show persistent low-grade high Tc (37-38°C) during situations of chronic stress. The mechanism for psychogenic fever is not yet fully understood. However, clinical case reports demonstrate that psychogenic fever is not attenuated by antipyretic drugs, but by psychotropic drugs that display anxiolytic and sedative properties, or by resolving patients' difficulties via natural means or psychotherapy...
July 2015: Temperature: Multidisciplinary Biomedical Journal
H Kletkiewicz, J Rogalska, A Nowakowska, A Wozniak, C Mila-Kierzenkowska, M Caputa
It is well known that decrease in body temperature provides protection to newborns subjected to anoxia/ischemia. We hypothesized that the normal body temperature of 33°C in neonatal rats (4°C below normal body temperature in adults) is in fact a preadaptation to protect CNS from anoxia and further reductions as well as elevations in temperature may be counterproductive. Our experiments aimed to examine the effect of changes in body temperature on oxidative stress development in newborn rats exposed to anoxia...
April 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Mate Puljiz, Michael Orlishausen, Werner Köhler, Andreas M Menzel
Selectively heating a microscopic colloidal particle embedded in a soft elastic matrix is a situation of high practical relevance. For instance, during hyperthermic cancer treatment, cell tissue surrounding heated magnetic colloidal particles is destroyed. Experiments on soft elastic polymeric matrices suggest a very long-ranged, non-decaying radial component of the thermophoretically induced displacement fields around the microscopic heat centers. We theoretically confirm this conjecture using a macroscopic hydrodynamic two-fluid description...
May 14, 2016: Journal of Chemical Physics
Ida S Frøysnes, Stein G Larsen, Milan Spasojevic, Svein Dueland, Kjersti Flatmark
BACKGROUND AND OBJECTIVES: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) can offer long-term survival to patients with resectable peritoneal metastasis (PM) from colorectal cancer (CRC), a condition with otherwise dismal prognosis. This study describes short- and long-term outcome in a national patient cohort and aims to identify prognostic factors. METHODS: All patients treated with CRS-HIPEC for non-appendiceal PM-CRC in Norway 2004-2013 were included (n = 119), and outcome and potential prognostic factors were examined using survival- and ROC-curve analysis...
August 2016: Journal of Surgical Oncology
Xiang Zeng, Inbo Han, Muhammad Abd-El-Barr, Zaid Aljuboori, Jamie E Anderson, John H Chi, Ross D Zafonte, Yang D Teng
The adult rodent spinal cord presents an inhibitory environment for donor cell survival, impeding efficiency for xenograft-based modeling of gliomas. We postulated that mild thermal precondition may influence the fate of the implanted tumor cells. To test this hypothesis, high grade human astrocytoma G55 and U87 cells were cultured under 37°C and 38.5°C, to mimic regular experimental or core body temperature of rodents, respectively. In vitro, 38.5°C-conditioned cells, relative to 37°C, grew slightly faster...
May 4, 2016: Cell Transplantation
Sze Ying Thong, Claramae Shulyn Chia, Oriana Ng, Grace Tan, Ee Teng Ong, Khee Chee Soo, Melissa Teo
INTRODUCTION: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are the treatment of choice for selected patients with peritoneal carcinomatosis, which was previously a lethal condition with dismal survival rate. METHODS: We reviewed all CRS and HIPEC procedures performed at our centre from January 1997 to December 2012, with a focus on perioperative events and anaesthetic implications. RESULTS: In total, 111 patients underwent 113 procedures...
April 28, 2016: Singapore Medical Journal
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