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https://www.readbyqxmd.com/read/29452671/what-is-the-optimal-initial-management-of-the-younger-mantle-cell-lymphoma-patient
#1
REVIEW
Rory McCulloch, Simon Rule
The last 20 years has seen considerable advances made in the management of younger patients with mantle cell lymphoma. The use of high dose cytarabine and rituximab in induction therapy, usually followed by autologous stem cell transplant consolidation, has become established practice and the median overall survival now exceeds 10 years. However, this high intensity upfront approach is not necessarily appropriate for all newly diagnosed patients. A minority exhibit disease that behaves in an indolent fashion with no proven benefit from early intervention, and at the opposite end of the spectrum a high-risk group exists who do poorly with conventional treatment...
March 2018: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29447810/no-evidence-of-cholesteatoma-in-untreated-otitis-media-with-effusion-in-children-with-primary-ciliary-dyskinesia
#2
Reshma Ghedia, Jahangir Ahmed, Annakan Navaratnam, Jonny Harcourt
INTRODUCTION: Primary Ciliary Dyskinesia (PCD) describes a group of inherited disorders that result in abnormal ciliary motion leading to mucous stasis. Clinical features include almost universally otitis media with effusion (OME), particularly in infants. PCD patients provide us with a cohort of patients with OME that is not treated with ventilatory tube (VT) insertion as these have been shown to result in frequent complications including chronic otorrhoea, early extrusion and persistent perforation without significant improvement to hearing in the long term...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29439670/phase-i-study-of-an-active-immunotherapy-for-asymptomatic-phase-lymphoplasmacytic-lymphoma-with-dna-vaccines-encoding-antigen-chemokine-fusion-study-protocol
#3
Sheeba K Thomas, Soung-Chul Cha, D Lynne Smith, Kun Hwa Kim, Sapna R Parshottam, Sheetal Rao, Michael Popescu, Vincent Y Lee, Sattva S Neelapu, Larry W Kwak
BACKGROUND: There is now a renewed interest in cancer vaccines. Patients responding to immune checkpoint blockade usually bear tumors that are heavily infiltrated by T cells and express a high load of neoantigens, indicating that the immune system is involved in the therapeutic effect of these agents; this finding strongly supports the use of cancer vaccine strategies. Lymphoplasmacytic lymphoma (LPL) is a low grade, incurable disease featuring an abnormal proliferation of Immunoglobulin (Ig)-producing malignant cells...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29436326/addressing-alcohol-related-dementia-should-involve-better-detection-not-watchful-waiting
#4
Rahul Tony Rao, Brian Draper
Alcohol-related dementia represents an underrecognised mental disorder with both clinical and public mental health aspects. There is considerable scope for improving its assessment within both mainstream and specialist mental health services, but ongoing challenges remain in ensuring its timely detection so that appropriate preventative and rehabilitative interventions can be applied. Declaration of interest None.
February 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29428868/mapping-the-cancer-patient-information-landscape-a-comparative-analysis-of-patient-groups-across-europe-and-north-america
#5
Mark Lawler, Gillian Prue, Ian Banks, Kate Law, Peter Selby, Gordon McVie, Richard Sullivan
AIM: Little is known about how patient groups provide information for patients. We invited 838 patient groups from Europe and North America to participate in an online survey. METHODS: The survey covered: (i) availability, accessibility and quality of information provided; (ii) methods by which patient groups communicate; (iii) ways in which patient groups acquire information and confirm its veracity/accuracy; (iv) how people access information online. RESULTS: European patient groups were significantly less effective in providing medical-related information than their North American counterparts in: clinical trials, potential causes of cancer, medical research, diagnosis/screening, symptoms, treatments (all p < 0...
February 8, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29425140/an-experimental-exploration-of-the-effects-of-exposure-to-images-of-nature-on-rumination
#6
Sarah Elizabeth Golding, Birgitta Gatersleben, Mark Cropley
Exposure to natural environments has been shown to have beneficial effects on mood. Rumination is a thinking style associated with negative mood, and sometimes depression, and is characterized by repetitive, intrusive thoughts, often with a negative emotional element. This study investigated whether exposure to nature, operationalized using photographs presented as a slideshow, could aid reduction in levels of state rumination. An experimental, within-between (Time x Condition) participant design was used; participants (n = 58) undertook a presentation task designed to induce rumination and influence mood...
February 9, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29420434/quality-of-life-in-patients-with-rectal-cancer-after-chemoradiation-watch-and-wait-policy-versus-standard-resection-are-we-comparing-apples-to-oranges
#7
Bruna Borba Vailati, Angelita Habr-Gama, Adrian E Mattacheo, Guilherme Pagin São Julião, Rodrigo Oliva Perez
No abstract text is available yet for this article.
March 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29419913/variation-in-the-diagnosis-and-clinical-management-of-lentigo-maligna-across-europe-a-survey-study-among-eadv-members
#8
D Tio, C A C Prinsen, B Dréno, R Hoekzema, M Augustin, C van Montfrans
BACKGROUND: Lentigo maligna (LM), a form of melanoma in situ, is treated to prevent progression to lentigo maligna melanoma (LMM). Surgical treatment is the gold standard. However, treatment guidelines are based on expert opinion and comparative studies are lacking. OBJECTIVE: The objective of this study is to assess the diagnostic methods and clinical management of LM patients among European dermatologists and residents. METHODS: A survey consisting of 29 questions about diagnostic methods and treatment options used for LM patients was sent to 3308 members of the European association of Dermatologists and Venereologists (EADV)...
February 8, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29415976/clinical-management-and-outcomes-of-completely-resected-stage-i-follicular-lymphoma
#9
Akihiko Yokohama, Yoko Hashimoto, Makiko Takizawa, Hiroaki Shimizu, Yuri Miyazawa, Akio Saitoh, Kohtaro Toyama, Takuma Ishizaki, Takeki Mitsui, Takayuki Saitoh, Kayoko Murayama, Morio Matsumoto, Morio Sawamura, Hirokazu Murakami, Junko Hirato, Masaru Kojima, Yoshihisa Nojima, Hiroshi Handa, Norifumi Tsukamoto
Recent studies have revealed the clinical and biological features of stage I follicular lymphoma (FL), but information about patients with stage I FL who underwent total resection after tissue biopsy is limited. Among 305 FL patients diagnosed between 2001 and 2013, clinical stage I disease was observed in 36 patients. Of these, 18 patients underwent total resection after diagnostic tissue biopsy. We used 18F-fluorodeoxyglucose positron emission CT for staging assessment in 13 of 18 patients (72.2%). The median age was 56...
February 8, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29415595/reasons-for-initiation-of-treatment-and-predictors-of-response-for-patients-with-rai-stage-0-1-chronic-lymphocytic-leukemia-cll-receiving-first-line-therapy-an-analysis-of-the-connect%C3%A2-cll-cohort-study
#10
Christopher R Flowers, Chadi Nabhan, Neil E Kay, Anthony Mato, Nicole Lamanna, Charles M Farber, Matthew S Davids, Pavel Kiselev, Arlene S Swern, Kristen Sullivan, E Dawn Flick, Jeff P Sharman
A 'watch-and-wait' strategy is recommended for most patients with early-stage chronic lymphocytic leukemia (CLL) prior to treatment initiation. In the Connect® CLL registry, a prospective observational cohort study of 1494 patients treated in 199 US centers, median time to first-line treatment initiation was 3.8, 1.5, and 0.6 years for patients with Rai stage 0, 1, and ≥2, respectively. Only 60% of patients with Rai stage 0/1 underwent FISH/cytogenetic testing prior to initiation of a new line of therapy...
February 7, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29410688/management-and-outcome-of-heterotopic-interstitial-pregnancy-case-report-and-review-of-literature
#11
REVIEW
Wendy Dendas, Jean-Christophe Schobbens, Greet Mestdagh, Liesbeth Meylaerts, Geert Verswijvel, Caroline Van Holsbeke
Objective: To report a case of heterotopic interstitial pregnancy after in vitro fertilization-embryo transfer (IVF-ET), presenting with a second trimester uterine rupture. To review the clinical presentations, risk factors, treatment options, and outcome of heterotopic interstitial pregnancies. Methods: We describe the clinical presentation, management, and outcome of a patient with a heterotopic interstitial pregnancy, diagnosed following second trimester rupture of the interstitial pregnancy...
August 2017: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/29398323/delaying-surgery-after-neoadjuvant-chemoradiotherapy-in-rectal-cancer-has-no-influence-in-surgical-approach-or-short-term-clinical-outcomes
#12
Nuno Figueiredo, Sofoklis Panteleimonitis, Sotiris Popeskou, Jose F Cunha, Tahseen Qureshi, Geerard L Beets, Richard J Heald, Amjad Parvaiz
AIMS: In rectal cancer, increasing the interval between the end of neoadjuvant chemoradiotherapy (CRT) and surgery could improve the pathological complete response (pCR) rates, allow full-dose neoadjuvant chemotherapy, and select patients with a clinical complete response (cCR) for inclusion in a "watch & wait" program (W&W). However, controversy arises from waiting more than 8-12 weeks after CRT, as it might increase fibrosis around the total mesorectal excision (TME) plane potentially leading to technical difficulties and higher surgical morbidity...
February 1, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29388060/how-is-rectal-cancer-managed-a-survey-exploring-current-practice-patterns-in-canada
#13
A Crawford, J Firtell, A Caycedo-Marulanda
INTRODUCTION: Locally advanced rectal cancers are most often treated with neoadjuvant chemoradiation followed by surgical resection. However, there are differing opinions surrounding management of rectal cancer, including a lack of consensus on the optimal time interval between chemoradiation and surgery, and the management of patients with complete clinical response following neoadjuvant therapy. This study seeks to summarize management trends for rectal cancer among a sample of Canadian surgeons...
February 1, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29382447/biopsychosocial-impact-of-prostate-cancer-and-androgen-deprivation-therapy
#14
Dean A Tripp, Phylicia Verreault, Steven Tong, Jason Izard, Angela Black, D Robert Siemens
INTRODUCTION: Prostate cancer is the most non-cutaneous malignancy in men, and androgen-deprivation therapy (ADT) is a cornerstone of management in advanced disease. The aim of this study was to evaluate the association of ADT with changes in depression and mental and physical quality of life (QoL) within a prospective patient cohort design. METHODS: Patients were prospectively recruited and consented at a single academic health sciences centre in Ontario, Canada...
October 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29382380/systemic-sclerosis-associated-interstitial-lung-disease-individualized-immunosuppressive-therapy-and-course-of-lung-function-results-of-the-eustar-group
#15
Sabine Adler, Dörte Huscher, Elise Siegert, Yannick Allanore, László Czirják, Francesco DelGaldo, Christopher P Denton, Oliver Distler, Marc Frerix, Marco Matucci-Cerinic, Ulf Mueller-Ladner, Ingo-Helmut Tarner, Gabriele Valentini, Ulrich A Walker, Peter M Villiger, Gabriela Riemekasten
BACKGROUND: Interstitial lung disease in systemic sclerosis (SSc-ILD) is a major cause of SSc-related death. Imunosuppressive treatment (IS) is used in patients with SSc for various organ manifestations mainly to ameliorate progression of SSc-ILD. Data on everyday IS prescription patterns and clinical courses of lung function during and after therapy are scarce. METHODS: We analysed patients fulfilling American College of Rheumatology (ACR)/European League against Rheumatism (EULAR) 2013 criteria for SSc-ILD and at least one report of IS...
January 30, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29377265/a-watch-and-wait-policy-versus-rituximab-combined-chemotherapy-in-japanese-patients-with-intestinal-follicular-lymphoma
#16
Akira Tari, Yasuhiko Kitadai, Ritsuo Mouri, Hidehiko Takigawa, Hideki Asaoku, Keiichiro Mihara, Katsuyoshi Takata, Megumu Fujihara, Tadashi Yoshino, Tadashi Koga, Shunji Fujimori, Shinji Tanaka, Kazuaki Chayama
BACKGROUND: Few reports have demonstrated the effectiveness of treatments for intestinal follicular lymphoma (FL) because of the limited number of patients who undergo comprehensive small intestinal examinations. This study compared the efficacy of rituximab-combined chemotherapy in patients with asymptomatic and low tumor burden (LTB) intestinal FL, according to the criteria of the Groupe d'Etude des Lymphomes Folliculaires, with that of a "watch and wait" (W&W) approach. METHODS: The endoscopic examination for entire gastrointestinal tracts was performed in 29 Japanese patients with intestinal FL...
January 29, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29373328/nature-and-role-of-surgical-margins-in-transoral-laser-microsurgery-for-early-and-intermediate-glottic-cancer
#17
Ivana Fiz, Jan Constantin Koelmel, Christian Sittel
PURPOSE OF REVIEW: Summarize recent findings regarding the impact of margin status on oncologic outcomes and organ preservation, as well as evaluate possible management policies of close and positive margins after transoral laser microsurgery (TLM) for Tis-T2 glottic carcinomas. RECENT FINDINGS: Impact of margin status on survival rates remains controversial, whereas some authors found close and positive margins to be independent risk factors for recurrence and poorer survival rates, others did not find any significant variations compared with negative ones...
January 25, 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29373089/multiparametric-mr-imaging-of-the-prostate-after-treatment-of-prostate-cancer
#18
Pritesh Patel, Melvy S Mathew, Igor Trilisky, Aytekin Oto
The use of multiparametric magnetic resonance (MR) imaging in prostate cancer therapy is increasing, as newer treatment methods and management approaches emerge. The mainstays of therapy-radiation and surgery-are being supplemented (and even replaced) by novel focal therapy methods. Laser and ultrasonographic ablation, photodynamic therapy, electroporation, and cryoablation are the most common focal therapies, each with its own imaging findings. Typical ablation zones have a central focus of enhancement with peripheral rim enhancement; thus, dynamic contrast material-enhanced (DCE) MR imaging is the most important sequence for evaluation of treatment in the immediate posttherapeutic setting...
January 26, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29369484/characteristics-and-management-of-ganglioneuroma-and-ganglioneuroblastoma-intermixed-in-children-and-adolescents
#19
Natasha Alexander, Katie Sullivan, Furqan Shaikh, Meredith S Irwin
BACKGROUND: Ganglioneuromas (GNs) usually demonstrate favorable histological and clinical features. Surgery is often performed due to clinical symptoms and/or theoretical concerns that GN may transform into neuroblastoma (NB); however, several studies have identified significant GN-surgical morbidities. OBJECTIVES: We compared the natural history, biological and clinical features of GN and ganglioneuroblastoma-intermixed (GNB-I) managed by surgery or observation to inform management and surveillance...
January 25, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29362144/gas-induced-susceptibility-artefacts-on-diffusion-weighted-mri-of-the-rectum-at-1-5%C3%A2-t-effect-of-applying-a-micro-enema-to-improve-image-quality
#20
Joost J M van Griethuysen, Elyse M Bus, Michael Hauptmann, Max J Lahaye, Monique Maas, Leon C Ter Beek, Geerard L Beets, Frans C H Bakers, Regina G H Beets-Tan, Doenja M J Lambregts
PURPOSE: Assess whether application of a micro-enema can reduce gas-induced susceptibility artefacts in Single-shot Echo Planar Imaging (EPI) Diffusion-weighted imaging of the rectum at 1.5 T. MATERIALS AND METHODS: Retrospective analysis of n = 50 rectal cancer patients who each underwent multiple DWI-MRIs (1.5 T) from 2012 to 2016 as part of routine follow-up during a watch-and-wait approach after chemoradiotherapy. From March 2014 DWI-MRIs were routinely acquired after application of a preparatory micro-enema (Microlax®; 5 ml; self-administered shortly before acquisition); before March 2014 no bowel preparation was given...
February 2018: European Journal of Radiology
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