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https://www.readbyqxmd.com/read/27909954/fortifying-the-corrective-nature-of-post-publication-peer-review-identifying-weaknesses-use-of-journal-clubs-and-rewarding-conscientious-behavior
#1
Jaime A Teixeira da Silva, Aceil Al-Khatib, Judit Dobránszki
Most departments in any field of science that have a sound academic basis have discussion groups or journal clubs in which pertinent and relevant literature is frequently discussed, as a group. This paper shows how such discussions could help to fortify the post-publication peer review (PPPR) movement, and could thus fortify the value of traditional peer review, if their content and conclusions were made known to the wider academic community. Recently, there are some tools available for making PPPR viable, either as signed (PubMed Commons) or anonymous comments (PubPeer), or in a hybrid format (Publons)...
December 1, 2016: Science and Engineering Ethics
https://www.readbyqxmd.com/read/27907216/correction-deciphering-transcriptome-and-complex-alternative-splicing-transcripts-in-mammary-gland-tissues-from-cows-naturally-infected-with-staphylococcus-aureus-mastitis
#2
Xiu Ge Wang, Zhi Hua Ju, Ming Hai Hou, Qiang Jiang, Chun Hong Yang, Yan Zhang, Yan Sun, Rong Ling Li, Chang Fa Wang, Ji Feng Zhong, Jin Ming Huang
[This corrects the article DOI: 10.1371/journal.pone.0159719.].
2016: PloS One
https://www.readbyqxmd.com/read/27904153/genotype-and-phenotype-characterization-in-a-spanish-cohort-with-isovaleric-acidemia
#3
María L Couce, Luís Aldamiz-Echevarría, María A Bueno, Patricia Barros, Amaya Belanger-Quintana, Javier Blasco, María-Teresa García-Silva, Ana M Márquez-Armenteros, Isidro Vitoria, Inmaculada Vives, Rosa Navarrete, Ana Fernández-Marmiesse, Belén Pérez, Celia Pérez-Cerdá
Isovaleric acidemia (IVA) is a rare disorder of leucine metabolism. We carried out a multicenter study of IVA patients diagnosed by newborn screening (NBS) or symptoms clinics over a period of 28 years in Spain. Evaluated at diagnosis, data included age, detection method, levels of C5 and IVG, enzymatic studies, clinical presentation parameters and genotype in 16 patients. Follow-up data included C5 levels, intellectual quotient and correlation genotype-phenotype. IVA was detected by NBS in 8 patients (prevalence of 1/326 629)...
December 1, 2016: Journal of Human Genetics
https://www.readbyqxmd.com/read/27903563/leveraging-ongoing-research-to-evaluate-the-health-impacts-of-south-africa-s-salt-reduction-strategy-a-prospective-nested-cohort-within-the-who-sage-multicountry-longitudinal-study
#4
Karen Charlton, Lisa J Ware, Elias Menyanu, Richard Berko Biritwum, Nirmala Naidoo, Chiné Pieterse, Savathree Lorna Madurai, Jeannine Baumgartner, George A Asare, Elizabeth Thiele, Aletta E Schutte, Paul Kowal
INTRODUCTION: Attempting to curb the rising epidemic of hypertension, South Africa implemented legislation in June 2016 mandating maximum sodium levels in a range of manufactured foods that contribute significantly to population salt intake. This natural experiment, comparing two African countries with and without salt legislation, will provide timely information on the impact of legislative approaches addressing the food supply to improve blood pressure in African populations. This article outlines the design of this ongoing prospective nested cohort study...
November 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/27902638/the-pathophysiology-of-geographic-atrophy-secondary-to-age-related-macular-degeneration-and-the-complement-pathway-as-a-therapeutic-target
#5
David S Boyer, Ursula Schmidt-Erfurth, Menno van Lookeren Campagne, Erin C Henry, Christopher Brittain
PURPOSE: Geographic atrophy (GA) is an advanced, vision-threatening form of age-related macular degeneration (AMD) affecting approximately five million individuals worldwide. To date, there are no approved therapeutics for GA treatment; however, several are in clinical trials. This review focuses on the pathophysiology of GA, particularly the role of complement cascade dysregulation and emerging therapies targeting the complement cascade. METHODS: Primary literature search on PubMed for GA, complement cascade in age-related macular degeneration...
November 29, 2016: Retina
https://www.readbyqxmd.com/read/27899792/nature-nurtures-the-design-of-new-semi-synthetic-macrolide-antibiotics
#6
REVIEW
Prabhavathi Fernandes, Evan Martens, David Pereira
Erythromycin and its analogs are used to treat respiratory tract and other infections. The broad use of these antibiotics during the last 5 decades has led to resistance that can range from 20% to over 70% in certain parts of the world. Efforts to find macrolides that were active against macrolide-resistant strains led to the development of erythromycin analogs with alkyl-aryl side chains that mimicked the sugar side chain of 16-membered macrolides, such as tylosin. Further modifications were made to improve the potency of these molecules by removal of the cladinose sugar to obtain a smaller molecule, a modification that was learned from an older macrolide, pikromycin...
November 30, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27899150/reporting-of-statistically-significant-results-at-clinicaltrials-gov-for-completed-superiority-randomized-controlled-trials
#7
Agnes Dechartres, Elizabeth G Bond, Jordan Scheer, Carolina Riveros, Ignacio Atal, Philippe Ravaud
BACKGROUND: Publication bias and other reporting bias have been well documented for journal articles, but no study has evaluated the nature of results posted at ClinicalTrials.gov. We aimed to assess how many randomized controlled trials (RCTs) with results posted at ClinicalTrials.gov report statistically significant results and whether the proportion of trials with significant results differs when no treatment effect estimate or p-value is posted. METHODS: We searched ClinicalTrials...
November 30, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27898135/complementary-and-integrative-therapies-for-persistent-pain-management-in-older-adults-a-review
#8
Patricia Bruckenthal, Marie Ann Marino, Lisa Snelling
Management of persistent pain in older adults is challenging given the prevalence of multiple comorbid painful conditions, polypharmacy, age-related changes restricting pharmacological options, and socioeconomic factors. The influences of these factors along with current concern for the use of opioid analgesics highlight the importance of incorporating complementary and integrative medicine approaches. Evidence suggests efficacy and satisfaction with integrating complementary pain management strategies for older adults, especially yoga, massage, and natural products...
December 1, 2016: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/27898053/microbial-mutualism-dynamics-governed-by-dose-dependent-toxicity-of-cross-fed-nutrients
#9
Breah LaSarre, Alexandra L McCully, Jay T Lennon, James B McKinlay
Microbial interactions, including mutualistic nutrient exchange (cross-feeding), underpin the flow of energy and materials in all ecosystems. Metabolic exchanges are difficult to assess within natural systems. As such, the impact of exchange levels on ecosystem dynamics and function remains unclear. To assess how cross-feeding levels govern mutualism behavior, we developed a bacterial coculture amenable to both modeling and experimental manipulation. In this coculture, which resembles an anaerobic food web, fermentative Escherichia coli and photoheterotrophic Rhodopseudomonas palustris obligately cross-feed carbon (organic acids) and nitrogen (ammonium)...
November 29, 2016: ISME Journal
https://www.readbyqxmd.com/read/27894784/hospital-admission-in-older-persons-presenting-with-dizziness-in-the-emergency-department
#10
Anna Ekwall, Johanna Schrab, Karolina Runesson, Måns Magnussons
One of the most frequent chief complaints among older persons presenting in the emergency department (ED) is dizziness. Nurses in the ambulance and in the ED play an important role in managing these patients. The challenge in the ED or ambulance is to, with limited diagnostic equipment; decide the correct level of care. The aim of this study was to identify factors that differed between those who were admitted to hospital and those who were not among older persons (65+) presenting in the ED with dizziness. The method was a retrospective journal audit...
November 25, 2016: International Emergency Nursing
https://www.readbyqxmd.com/read/27872374/what-s-statistical-about-learning-insights-from-modelling-statistical-learning-as-a-set-of-memory-processes
#11
REVIEW
Erik D Thiessen
Statistical learning has been studied in a variety of different tasks, including word segmentation, object identification, category learning, artificial grammar learning and serial reaction time tasks (e.g. Saffran et al. 1996 Science 274: , 1926-1928; Orban et al. 2008 Proceedings of the National Academy of Sciences 105: , 2745-2750; Thiessen & Yee 2010 Child Development 81: , 1287-1303; Saffran 2002 Journal of Memory and Language 47: , 172-196; Misyak & Christiansen 2012 Language Learning 62: , 302-331). The difference among these tasks raises questions about whether they all depend on the same kinds of underlying processes and computations, or whether they are tapping into different underlying mechanisms...
January 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27870047/a-keystone-ecologist-robert-treat-paine-1933-2016
#12
James A Estes, Paul K Dayton, Peter Kareiva, Simon A Levin, Jane Lubchenco, Bruce A Menge, Stephen R Palumbi, Mary E Power, John Terborgh
Robert T. Paine, who passed away on 13 June 2016, is among the most influential people in the history of ecology. Paine was an experimentalist, a theoretician, a practitioner, and proponent of the "ecology of place," and a deep believer in the importance of natural history to ecological understanding. His scientific legacy grew from the discovery of a link between top-down forcing and species diversity, a breakthrough that led to the ideas of both keystone species and trophic cascades, and to our early understanding of the mosaic nature of biological communities, causes of zonation across physical gradients, and the intermediate-disturbance hypothesis of species diversity...
November 2016: Ecology
https://www.readbyqxmd.com/read/27867283/from-virgin-births-to-octomom-representations-of-single-motherhood-via-sperm-donation-in-the-uk-news
#13
S Zadeh, J Foster
The use of sperm donation by single women has provoked public, professional and political debate. Newspapers serve as a critical means of both broadcasting this debate and effecting a representation of this user group within the public sphere. This study uses the theory of social representations to examine how single motherhood by sperm donation has been represented in the UK news over time. The study sampled news coverage on this topic in eight British newspapers during three 4-year periods between the years 1988 and 2012...
November 2016: Journal of Community & Applied Social Psychology
https://www.readbyqxmd.com/read/27867203/epac2a-null-mice-exhibit-obesity-prone-nature-more-susceptible-to-leptin-resistance
#14
M Hwang, Y Go, J-H Park, S-K Shin, S E Song, B-C Oh, S-S Im, I Hwang, Y H Jeon, I-K Lee, S Seino, D-K Song
BACKGROUND: The exchange protein directly activated by cAMP (Epac), which is primarily involved in cAMP signaling, has been known to be essential for controlling body energy metabolism. Epac has two isoforms: Epac1 and Epac2. The function of Epac1 on obesity was unveiled using Epac1 knockout (KO) mice. However, the role of Epac2 in obesity remains unclear. METHODS: To evaluate the role of Epac2 in obesity, we used Epac2a KO mice, which is dominantly expressed in neurons and endocrine tissues...
November 21, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27864255/improving-self-management-of-cancer-risk-factors-underscreening-for-cancer-and-depression-among-general-practice-patients-study-protocol-of-a-randomised-controlled-trial
#15
Mariko Carey, Rob Sanson-Fisher, Christopher Oldmeadow, Elise Mansfield, Justin Walsh
INTRODUCTION: General practitioners have a key role in reducing cancer risk factors, screening for cancer and managing depression. Given the time-limited nature of consultations, a new and more time-efficient approach is needed which addresses multiple health needs simultaneously, and encourages patient self-management to address health risks. The aim of this cluster randomised controlled trial is to test the effectiveness of a patient feedback intervention in improving patient self-management of health needs related to smoking, risky alcohol consumption and underscreening for cancers at 1 month follow-up...
November 18, 2016: BMJ Open
https://www.readbyqxmd.com/read/27863928/a-scoping-review-of-the-role-of-lego-%C3%A2-therapy-for-improving-inclusion-and-social-skills-among-children-and-youth-with-autism
#16
REVIEW
Sally Lindsay, Kara Grace Hounsell, Celia Cassiani
BACKGROUND: LEGO(®) therapy uses children's natural interest in play to help motivate behavioural change and may be an effective teaching tool to increase social competency and communication skills. Although the literature is growing it has not been synthesized. OBJECTIVES: To review the literature on the role of LEGO(®) therapy on social skills and inclusion among children and youth with Autism Spectrum Disorder (ASD). METHODS: A scoping review was conducted, involving comprehensive searches of international databases...
November 10, 2016: Disability and Health Journal
https://www.readbyqxmd.com/read/27860525/emerging-themes-in-our-understanding-of-species-displacements
#17
Yulin Gao, Stuart R Reitz
The displacement of a species from a habitat by actions of another is the most severe outcome of interspecific interactions. This review focuses on recent developments in the understanding of (a) ecological mechanisms that lead to displacements, (b) how outcomes of interspecific interactions are affected by the context of where and when they occur, and (c) impacts of displacements. Displacements are likely to escalate as their primary initiating factors-the spread of non-native species and environmental change-continue at unprecedented rates...
November 4, 2016: Annual Review of Entomology
https://www.readbyqxmd.com/read/27860524/insect-pathogenic-fungi-genomics-molecular-interactions-and-genetic-improvements
#18
Chengshu Wang, Sibao Wang
Entomopathogenic fungi play a pivotal role in the regulation of insect populations in nature, and representative species have been developed as promising environmentally friendly mycoinsecticides. Recent advances in the genome biology of insect pathogenic fungi have revealed genomic features associated with fungal adaptation to insect hosts and different host ranges, as well as the evolutionary relationships between insect and noninsect pathogens. By using species in the Beauveria and Metarhizium genera as models, molecular biology studies have revealed the genes that function in fungus-insect interactions and thereby contribute to fungal virulence...
November 4, 2016: Annual Review of Entomology
https://www.readbyqxmd.com/read/27859435/a-qm-mm-study-of-the-nature-of-the-entatic-state-in-plastocyanin
#19
Catherine A Hurd, Nicholas A Besley, David Robinson
Plastocyanin is a copper containing protein that is involved in the electron transfer process in photosynthetic organisms. The active site of plastocyanin is described as an entatic state whereby its structure represents a compromise between the structures favored by the oxidized and reduced forms. In this study, the nature of the entatic state is investigated through density functional theory-based hybrid quantum mechanics/molecular mechanics (QM/MM) molecular dynamics simulations. The strain energy is computed to be 12...
November 14, 2016: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/27859320/advanced-literature-analysis-in-a-big-data-world
#20
Chris Cheadle, Hongbao Cao, Andrey Kalinin, Jaqui Hodgkinson
Comprehensive data mining of the scientific literature has become an increasing challenge. To address this challenge, Elsevier's Pathway Studio software uses the techniques of natural language processing to systematically extract specific biological information from journal articles and abstracts that is then used to create a very large, structured, and constantly expanding literature knowledgebase. Highly sophisticated visualization tools allow the user to interactively explore the vast number of connections created and stored in the Pathway Studio database...
November 10, 2016: Annals of the New York Academy of Sciences
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