keyword
https://read.qxmd.com/read/38498039/reducing-loneliness-and-social-isolation-of-older-adults-through-voice-assistants-literature-review-and-bibliometric-analysis
#1
REVIEW
Rachele Alessandra Marziali, Claudia Franceschetti, Adrian Dinculescu, Alexandru Nistorescu, Dominic Mircea Kristály, Adrian Alexandru Moșoi, Ronny Broekx, Mihaela Marin, Cristian Vizitiu, Sorin-Aurel Moraru, Lorena Rossi, Mirko Di Rosa
BACKGROUND: Loneliness and social isolation are major public health concerns for older adults, with severe mental and physical health consequences. New technologies may have a great impact in providing support to the daily lives of older adults and addressing the many challenges they face. In this scenario, technologies based on voice assistants (VAs) are of great interest and potential benefit in reducing loneliness and social isolation in this population, because they could overcome existing barriers with other digital technologies through easier and more natural human-computer interaction...
March 18, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38498005/novel-potential-of-rose-essential-oil-as-a-powerful-plant-defense-potentiator
#2
JOURNAL ARTICLE
Eiki Kaneko, Kenji Matsui, Ruka Nakahara, Gen-Ichiro Arimura
Terpenoids, natural compounds released by plants, function to enhance plant defense. The aim of this study was to investigate the effects of terpenoid-enriched essential oils (EOs) on tomato plants. From the application of a highly diluted solution of 11 different EOs to potted tomato soil, our study showed that rose essential oil (REO), rich in β-citronellol, played a crucial role in activating defense genes in tomato leaves. As a result, leaf damage caused by herbivores, such as Spodoptera litura and Tetranychus urticae , was significantly reduced...
March 18, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38497784/unraveling-the-ligand-specificity-and-promiscuity-of-the-staphylococcus-aureus-nora-efflux-pump-a-computational-study
#3
JOURNAL ARTICLE
Esra Büşra Işık, Onur Serçinoğlu
Staphylococcus aureus , a gram-positive bacterial pathogen, develops antibiotic resistance partly through enhanced activity of transmembrane multi-drug efflux pump proteins like NorA. Being a prominent member of the Major Facilitator Superfamily (MFS), NorA transports various small molecules including hydrophilic fluoroquinolone antibiotics across the cell membrane. Intriguingly, NorA is inhibited by a structurally diverse set of small molecule inhibitors as well, indicating a highly promiscuous ligand/inhibitor recognition...
March 18, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38497770/computational-choreography-dissecting-the-dance-of-hydrogen-bonding-and-%C3%AF-%C3%AF-stacking-in-the-fluorescence-discrimination-mechanism-of-ciprofloxacin-with-supramolecular-assembly
#4
JOURNAL ARTICLE
Jaymin Parikh, Keyur Bhatt, Krunal Modi, Ajay Desai, Nihal Patel, Chirag Patel, Ravibhai Bhola
The detailed binding insight between the fluorophore and analyte plays a pivotal role in the design of an efficient chemosensor for water pollution. In this study, we designed a picolinic acid-functionalized calix[4]pyrrole ligand (PCACP). When testing out the fluorescence study with selected antibiotics, we observed remarkable enhancement of fluorescence spectra in the presence of ciprofloxacin, singling out the PCACP_Ciprofloxacin complex. The detailed binding mechanism is explored via computational methods including molecular docking and dynamics, DFT (density functional theory) and NBO (Natural Bonding Orbital) analysis...
March 18, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38497763/enantioselective-divergent-syntheses-of-diterpenoid-pyrones
#5
JOURNAL ARTICLE
Yunpeng Ji, Yaqian Liu, Weiqiang Guan, Chuning Guo, Hongli Jia, Benke Hong, Houhua Li
Capitalizing a synergy between late-stage C(sp3 )-H alkynylation and a series of transition metal-catalyzed alkyne functionalization reactions, we reported herein enantioselective divergent synthesis of 10 diterpenoid pyrones within 14-16 steps starting from chiral pool enoxolone, including the first enantioselective synthesis of higginsianins A, B, D, E, and metarhizin C. Our synthesis also highlights an unprecedented biomimetic oxidative rearrangement of α-pyrone into 3(2H)-furanone, as well as applications of Echavarren C(sp3 )-H alkynylation reaction and Toste chiral counterion-mediated Au-catalyzed intramolecular allene hydroalkoxylation in natural product synthesis...
March 18, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38497707/molecular-and-supramolecular-materials-from-light-harvesting-to-quantum-information-science-and-technology
#6
REVIEW
Yipeng Zhang, Catrina P Oberg, Yue Hu, Hongxue Xu, Mengwen Yan, Gregory D Scholes, Mingfeng Wang
The past two decades have witnessed immense advances in quantum information technology (QIT), benefited by advances in physics, chemistry, biology, and materials science and engineering. It is intriguing to consider whether these diverse molecular and supramolecular structures and materials, partially inspired by quantum effects as observed in sophisticated biological systems such as light-harvesting complexes in photosynthesis and the magnetic compass of migratory birds, might play a role in future QIT. If so, how? Herein, we review materials and specify the relationship between structures and quantum properties, and we identify the challenges and limitations that have restricted the intersection of QIT and chemical materials...
March 18, 2024: Journal of Physical Chemistry Letters
https://read.qxmd.com/read/38497677/sr2-b5o8-oh-2%C3%A2-b-oh-3-%C3%A2-h2o-a-strontium-borate-that-shows-deep-ultraviolet-transparent-nonlinear-optical-properties
#7
JOURNAL ARTICLE
Wei-Feng Chen, Jing-Yi Lu, Jing-Jing Li, You-Zhao Lan, Jian-Wen Cheng, Guo-Yu Yang
A new noncentrosymmetric strontium borate, P1-Sr2[B5O8(OH)]2·[B(OH)3]·H2O (1), has been synthesized under the hydrothermal condition. The P1-Sr2[B5O8(OH)]2·[B(OH)3]·H2O shows a layered B-O network with 9-ring windows in the ab plane. Sr2+ cations, H3BO3, and H2O molecules are located in the voids of layers and interlayers, respectively. The P1-Sr2[B5O8(OH)]2·[B(OH)3]·H2O is the first synthetic phase of veatchite, while the other three polymorphs are found in different natural minerals...
March 18, 2024: Chemistry: a European Journal
https://read.qxmd.com/read/38497578/impact-of-lanthanide-nd-3-gd-3-and-yb-3-ionic-field-strength-on-the-structure-and-thermal-expansion-of-phosphate-glasses
#8
JOURNAL ARTICLE
José A Jiménez, Richard Amesimenu, Madison Thomas
Phosphate glasses containing Nd3+ , Gd3+ , and Yb3+ as lanthanide ions are attractive for applications in laser materials, phototherapy lamps, and solar spectral converters. The composition-structure-property relation in this type of glass system is thus of interest from fundamental and applied perspectives. In this work, the impact of the differing ionic radius of Nd3+ , Gd3+ , and Yb3+ and consequent field strength on the physical properties of phosphate glasses is investigated, focusing ultimately on thermal expansion effects...
March 18, 2024: Journal of Physical Chemistry. B
https://read.qxmd.com/read/38497475/coarse-grained-modeling-of-dna-rna-hybrids
#9
JOURNAL ARTICLE
Eryk J Ratajczyk, Petr Šulc, Andrew J Turberfield, Jonathan P K Doye, Ard A Louis
We introduce oxNA, a new model for the simulation of DNA-RNA hybrids that is based on two previously developed coarse-grained models-oxDNA and oxRNA. The model naturally reproduces the physical properties of hybrid duplexes, including their structure, persistence length, and force-extension characteristics. By parameterizing the DNA-RNA hydrogen bonding interaction, we fit the model's thermodynamic properties to experimental data using both average-sequence and sequence-dependent parameters. To demonstrate the model's applicability, we provide three examples of its use-calculating the free energy profiles of hybrid strand displacement reactions, studying the resolution of a short R-loop, and simulating RNA-scaffolded wireframe origami...
March 21, 2024: Journal of Chemical Physics
https://read.qxmd.com/read/38497472/nature-and-energetics-of-low-lying-excited-singlets-triplets-and-intersystem-crossing-rates-in-selone-analogs-of-perylenediimide-a-theoretical-perspective
#10
JOURNAL ARTICLE
Annette Mariya Tedy, Arun K Manna
The structural rigidity and chemical diversity of the highly fluorescent perylenediimide (PDI) provide wide opportunities for developing triplet photosensitizers with sufficiently increased energy efficiency. Remarkably high intersystem crossing (ISC) rates with a complete fluorescence turn-off reported recently for several thione analogs of PDI due to substantially large spin-orbit coupling garners huge attention to develop other potential analogs. Here, several selone analogs of PDI, denoted as mSe-PDIs (m = 1-4) with varied Se content and positions, are investigated to provide a comprehensive and comparative picture down the group-16 using density functional theory (DFT) and time-dependent DFT implementing optimally tuned range-separated hybrid in toluene dielectric...
March 21, 2024: Journal of Chemical Physics
https://read.qxmd.com/read/38497430/characterization-of-a-molecularly-distinct-subset-of-oncocytic-pleomorphic-adenomas-myoepitheliomas-harboring-recurrent-zbtb47-as1-plag1-gene-fusion
#11
JOURNAL ARTICLE
Ziyad Alsugair, Jimmy Perrot, Françoise Descotes, Jonathan Lopez, Anne Champagnac, Daniel Pissaloux, Claire Castain, Mihaela Onea, Philippe Céruse, Pierre Philouze, Charles Lépine, Marie-Delphine Lanic, Marick Laé, Valérie Costes-Martineau, Nazim Benzerdjeb
Recurrent gene fusions are common in salivary gland tumors including benign tumors, such as pleomorphic adenoma (PA) and myoepithelioma (ME). In cases where chromosomal rearrangement is identified in the pleomorphic adenoma gene 1 (PLAG1) gene, different gene partners are found. Oncocytic metaplasia, characterized by oncocytes with abundant eosinophilic granular cytoplasm and hyperchromatic nuclei, is a well-known phenomenon in salivary gland neoplasms. However, the pure oncocytic variant of PA/ME showed PLAG1 gene rearrangements involving various gene partners at the molecular level, without any recurrent fusion being found...
March 18, 2024: American Journal of Surgical Pathology
https://read.qxmd.com/read/38497417/insulin-like-growth-factor-ii-mrna-binding-protein-3-is-a-highly-sensitive-marker-for-intravascular-large-b-cell-lymphoma-immunohistochemical-analysis-of-152-pathology-specimens-from-88-patients
#12
JOURNAL ARTICLE
Manduwa Saka, Masakazu Fujimoto, Kai Mizoguchi, Marina Tsujimura, Miho Saeki, Masahiro Hirata, Shinsuke Shibuya, Kentaro Odani, Takaki Sakurai, Yoshiaki Yuba, Koki Moriyoshi, Naoki Nakajima, Shinji Sumiyoshi, Fumihiko Kono, Kazuo Ono, Tomoyuki Shirase, Chihiro Watanabe, Akihiko Yoshizawa, Hironori Haga
Intravascular large B-cell lymphoma (IVLBCL) is a rare type of aggressive extranodal large B-cell lymphoma characterized by the selective growth of lymphoma cells within the lumina of blood vessels, particularly capillaries. IVLBCL lacks mass formation, and its diagnosis can be challenging. We analyzed the utility of insulin-like growth factor II mRNA-binding protein 3 (IMP3) immunohistochemistry for IVLBCL diagnosis in various organs. Double staining with paired box 5 (PAX5) was performed for validation. Overall, 152 pathological specimens (111 positive and 41 negative for IVLBCL) obtained from 88 patients with a diagnosis of IVLBCL were stained for IMP3 and IMP3/PAX5...
March 18, 2024: American Journal of Surgical Pathology
https://read.qxmd.com/read/38497406/effects-of-increasing-ligand-conjugation-in-cu-i-photosensitizers-on-nio-semiconductor-surfaces
#13
JOURNAL ARTICLE
Zujhar Singh, Joseph D Chiong, Saeid Kamal, Marek B Majewski
Dye-sensitized photoelectrodes may be used as heterogeneous components for fuel-forming reactions in photoelectrochemical cells. There has been increasing interest in developing Earth-abundant cheaper photosensitizers based on first-row transition metals. We describe here the synthesis, characterization, and study of the ground and excited state properties of three Cu(I) complexes bearing ligands with varying electron-accepting capacities and conjugation that may act as photosensitizers for wide bandgap semiconductors...
March 18, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/38497277/smiling-synchronization-predicts-interaction-enjoyment-in-peer-dyads-of-autistic-and-neurotypical-youth
#14
JOURNAL ARTICLE
Kathryn A McNaughton, Alexandra Moss, Heather A Yarger, Elizabeth Redcay
For autistic and neurotypical youth, having positive social interactions with other youth is an important part of well-being. Other researchers have found that one factor that can make people feel like social interactions have gone well is synchronization. Synchronization happens when peoples' body movements and facial expressions align while they're interacting. We focus on smiling synchronization here because other studies have found that when neurotypical individuals synchronize their smiles more in a social interaction, they say they enjoy that social interaction more...
March 18, 2024: Autism: the International Journal of Research and Practice
https://read.qxmd.com/read/38496860/heart-failure-with-sarcopenia-a-bibliometric-review-from-1995-to-2022
#15
REVIEW
Yaping You, Tiantian Meng, Xinyu Lu, Xueping Zhu, Meng Lv, Xintian Shou, Qingyong He, Yuanhui Hu
This study aimed to dynamically track the priorities and potential research hotspots in the field of heart failure with sarcopenia. Using CiteSpace, we analyzed the literature on heart failure with sarcopenia from the Web of Science database from 1995 to 2022. The analysis encompassed 507 records, revealing an overall upward trend in annual publication volume. Europe and the United States emerged as the primary regions for publishing, particularly driven by contributions from developed countries such as the United States, Germany, and Italy...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38496379/history-of-hpv-in-hpv-positive-elderly-women
#16
JOURNAL ARTICLE
Ruth S Hermansson, Gabriella Lillsunde-Larsson, Gisela Helenius, Mats G Karlsson, Malin Kaliff, Matts Olovsson, Annika K Lindström
BACKGROUND: The aim of this study was to examine the natural course of HPV infection in women of 60 years and older who were HPV positive at inclusion, and any association between HPV positivity in historical samples and dysplasia outcome. METHODS: Eighty-nine women aged 60-82 years, who tested positive for HPV between 2012 and 2016 were included. Sampling for cytology and/or histology was also performed. HPV genotyping was carried out on archived material back to 1999...
June 2024: European journal of obstetrics & gynecology and reproductive biology: X
https://read.qxmd.com/read/38496341/scoping-review-the-role-of-psychedelics-in-the-management-of-chronic-pain
#17
REVIEW
Christopher L Robinson, Alexandra C G Fonseca, Efemena M Diejomaoh, Ryan S D'Souza, Michael E Schatman, Vwaire Orhurhu, Trent Emerick
INTRODUCTION: Amid a lack of effective chronic pain treatments, psychedelics have gained attention as a potential solution, although their Schedule 1 classification poses challenges. Psychedelics, such as lysergic acid diethylamide (LSD) and psilocybin, have gained popularity as alternatives and adjuncts for chronic pain treatment. Studies suggest that they may modulate pain processing through agonism primarily at the serotonin receptor, 5-HT2A . One of the first of its nature, we present an artificial intelligence (AI)-powered scoping review primarily focusing on evaluating psychedelics for chronic pain conditions such as cluster headache, phantom limb pain, and fibromyalgia...
2024: Journal of Pain Research
https://read.qxmd.com/read/38496038/melanin-based-plumage-coloration-and-melanin-content-in-organs-in-the-barn-owl
#18
JOURNAL ARTICLE
Alexandre Roulin, Sylvain Dubey, Shosuke Ito, Kazumasa Wakamatsu
Although the evolutionary ecology of melanin pigments and melanin-based coloration has been studied in great details, particularly in birds, little is known about the function of melanin stored inside the body. In the barn owl Tyto alba , in which individuals vary in the degree of reddish pheomelanin-based coloration and in the size of black eumelanic feather spots, we measured the concentration in melanin pigments in seven organs. The eyes had by far the most melanin then the skin, pectoral muscle, heart, liver, trachea, and uropygial gland...
2024: Journal of Ornithology
https://read.qxmd.com/read/38495934/host-status-and-susceptibility-of-cannabis-sativa-cultivars-to-root-knot-nematodes
#19
JOURNAL ARTICLE
J Coburn, J Desaeger
Root-knot nematode host status of hemp cultivars of different uses (fiber, dual, CBD/CBG) and from different regions (Europe, China, US) were evaluated in five different greenhouse trials. None of the tested cultivars showed resistance to any of the tested root-knot nematode species, and all tested hemp cultivars were good hosts for root-knot nematodes, especially to mixed populations of M. javanica and M. incognita . Root gall symptoms on hemp were less severe than on cucumber (and tomato), but reproduction rates were similar...
March 2024: Journal of Nematology
https://read.qxmd.com/read/38495807/best-practice-recommendations-for-infertility-management
#20
JOURNAL ARTICLE
Jaideep Malhotra, M Gouri Devi, Madhuri Patil
AIM: The objective of this document is to provide guidance to the infertility specialist, gynecologist, embryologist, and counselors on the management of sub-fertility and brief them with the recent advances in the field. These recommendations will aid the aforementioned healthcare professionals in everyday clinical decisions about appropriate and effective care of their patients with the best available evidence. PARTICIPANTS: Extensive deliberations, discussion, and brainstorming was done between different reproductive medicine (RM) specialists, to develop the recommendations...
February 2024: Journal of Human Reproductive Sciences
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