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https://www.readbyqxmd.com/read/29140757/new-insights-into-lymphoma-pathogenesis
#1
Kojo S J Elenitoba-Johnson, Megan S Lim
Lymphomas represent clonal proliferations of lymphocytes that are broadly classified based upon their maturity (peripheral or mature versus precursor) and lineage (B cell, T cell, and natural killer cell). Insights into the pathogenetic mechanisms involved in lymphoma impact the classification of lymphoma and have significant implications for the diagnosis and clinical management of patients. Serial scientific and technologic advances over the last 30 years in immunology, cytogenetics, molecular biology, gene expression profiling, mass spectrometry-based proteomics, and, more recently, next-generation sequencing have contributed to greatly enhance our understanding of the pathogenetic mechanisms in lymphoma...
November 15, 2017: Annual Review of Pathology
https://www.readbyqxmd.com/read/29140727/population-genomics-of-herbicide-resistance-adaptation-via-evolutionary-rescue
#2
Julia M Kreiner, John R Stinchcombe, Stephen I Wright
The evolution of herbicide resistance in weed populations is a highly replicated example of adaptation surmounting the race against extinction, but the factors determining its rate and nature remain poorly understood. Here, we explore theory and empirical evidence for the importance of population genetic parameters-including effective population size, dominance, mutational target size, and gene flow-in influencing the probability and mode of herbicide resistance adaptation and its variation across species. We compiled data on the number of resistance mutations across populations for 79 herbicide-resistant species...
November 15, 2017: Annual Review of Plant Biology
https://www.readbyqxmd.com/read/29138482/valgamicin-c-a-novel-cyclic-depsipeptide-containing-the-unusual-amino-acid-cleonine-and-related-valgamicins-a-t-and-v-produced-by-amycolatopsis-sp-ml1-hf4
#3
Hideki Hashizume, Kiyoko Iijima, Kazuma Yamashita, Tomoyuki Kimura, Shun-Ichi Wada, Ryuichi Sawa, Masayuki Igarashi
In the course of optimizing pargamicin A production in Amycolatopsis sp. ML1-hF4, we discovered novel cyclic depsipeptide compounds in the broth and designated them valgamicins A, C, T and V. The structures of these molecules were determined by spectroscopic studies, advanced Marfey's method and X-ray crystal structural analysis. Valgamicin C contains the extremely rare amino acid cleonine. To our knowledge, this is the first report of a cleonine-containing metabolite from a naturally isolated microorganism without any breeding or mutation treatment...
November 15, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/29138045/cyclodextrins-structure-physicochemical-properties-and-pharmaceutical-applications
#4
Phatsawee Jansook, Noriko Ogawa, Thorsteinn Loftsson
Since their discovery over 100 years ago cyclodextrins (CDs) have been the subject of numerous scientific publications. In 2016 alone CDs were the subject of over 2200 research articles published in peer-reviewed journals and mentioned in over 2300 patents and patent applications, many of which were on pharmaceutical applications. Natural CDs and their derivatives are used as enabling pharmaceutical excipients that enhance aqueous solubility of poorly soluble drugs, increase drug permeability through biological membranes and improve drug bioavailability...
November 11, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29136036/correction-occurrence-of-leishmania-infantum-in-the-central-nervous-system-of-naturally-infected-dogs-parasite-load-viability-co-infections-and-histological-alterations
#5
https://www.readbyqxmd.com/read/29133316/study-protocol-for-think-a-multinational-open-label-phase-i-study-to-assess-the-safety-and-clinical-activity-of-multiple-administrations-of-nkr-2-in-patients-with-different-metastatic-tumour-types
#6
Caroline Lonez, Bikash Verma, Alain Hendlisz, Philippe Aftimos, Ahmad Awada, Eric Van Den Neste, Gaetan Catala, Jean-Pascal H Machiels, Fanny Piette, Jason B Brayer, David A Sallman, Tessa Kerre, Kunle Odunsi, Marco L Davila, David E Gilham, Frédéric F Lehmann
INTRODUCTION: NKR-2 are autologous T cells genetically modified to express a chimeric antigen receptor (CAR) comprising a fusion of the natural killer group 2D (NKG2D) receptor with the CD3ζ signalling domain, which associates with the adaptor molecule DNAX-activating protein of 10 kDa (DAP10) to provide co-stimulatory signal upon ligand binding. NKG2D binds eight different ligands expressed on the cell surface of many tumour cells and which are normally absent on non-neoplastic cells...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29130880/two-patients-and-two-knee-cysts
#7
Hale Ersoy, Stephen J Pomeranz
Differential diagnosis of a cystic lesion adjacent to menisci can be a challenge even when the case presents as seemingly straightforward. To "tell the story" as accurately as possible, the radiologist must be familiar with the natural history of these lesions as well as distinctive imaging features and must take all relevant factors into consideration, such as patient's age, activity level, and surgical history. This article presents two cases to illustrate how imaging features affect the report and management plan...
October 2017: Journal of Surgical Orthopaedic Advances
https://www.readbyqxmd.com/read/29129942/priorities-for-research-in-soil-ecology
#8
Nico Eisenhauer, Pedro M Antunes, Alison E Bennett, Klaus Birkhofer, Andrew Bissett, Matthew A Bowker, Tancredi Caruso, Baodong Chen, David C Coleman, Wietse de Boer, Peter de Ruiter, Thomas H DeLuca, Francesco Frati, Bryan S Griffiths, Miranda M Hart, Stephan Hättenschwiler, Jari Haimi, Michael Heethoff, Nobuhiro Kaneko, Laura C Kelly, Hans Petter Leinaas, Zoë Lindo, Catriona Macdonald, Matthias C Rillig, Liliane Ruess, Stefan Scheu, Olaf Schmidt, Timothy R Seastedt, Nico M van Straalen, Alexei V Tiunov, Martin Zimmer, Jeff R Powell
The ecological interactions that occur in and with soil are of consequence in many ecosystems on the planet. These interactions provide numerous essential ecosystem services, and the sustainable management of soils has attracted increasing scientific and public attention. Although soil ecology emerged as an independent field of research many decades ago, and we have gained important insights into the functioning of soils, there still are fundamental aspects that need to be better understood to ensure that the ecosystem services that soils provide are not lost and that soils can be used in a sustainable way...
July 2017: Pedobiologia
https://www.readbyqxmd.com/read/29129021/the-effect-of-natural-or-simulated-altitude-training-on-high-intensity-intermittent-running-performance-in-team-sport-athletes-a-meta-analysis
#9
REVIEW
Michael J Hamlin, Catherine A Lizamore, Will G Hopkins
BACKGROUND: While adaptation to hypoxia at natural or simulated altitude has long been used with endurance athletes, it has only recently gained popularity for team-sport athletes. OBJECTIVE: To analyse the effect of hypoxic interventions on high-intensity intermittent running performance in team-sport athletes. METHODS: A systematic literature search of five journal databases was performed. Percent change in performance (distance covered) in the Yo-Yo intermittent recovery test (level 1 and level 2 were used without differentiation) in hypoxic (natural or simulated altitude) and control (sea level or normoxic placebo) groups was meta-analyzed with a mixed model...
November 11, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29126380/what-makes-for-sound-science
#10
EDITORIAL
Fabrizio Costa, Grant Cramer, E Jean Finnegan
The inclusive threshold policy for publication in BMC journals including BMC Plant Biology means that editorial decisions are largely based on the soundness of the research presented rather than the novelty or potential impact of the work. Here we discuss what is required to ensure that research meets the requirement of scientific soundness. BMC Plant Biology and the other BCM-series journals ( https://www.biomedcentral.com/p/the-bmc-series-journals ) differ in policy from many other journals as they aim to provide a home for all publishable research...
November 10, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29125597/phage-mobility-is-a-core-determinant-of-phage-bacteria-coexistence-in-biofilms
#11
Matthew Simmons, Knut Drescher, Carey D Nadell, Vanni Bucci
Many bacteria are adapted for attaching to surfaces and for building complex communities, termed biofilms. The biofilm mode of life is predominant in bacterial ecology. So too is the exposure of bacteria to ubiquitous viral pathogens, termed bacteriophages. Although biofilm-phage encounters are likely to be common in nature, little is known about how phages might interact with biofilm-dwelling bacteria. It is also unclear how the ecological dynamics of phages and their hosts depend on the biological and physical properties of the biofilm environment...
November 10, 2017: ISME Journal
https://www.readbyqxmd.com/read/29124710/ultraviolet-irradiation-of-blood-the-cure-that-time-forgot
#12
Michael R Hamblin
Ultraviolet blood irradiation (UBI) was extensively used in the 1940s and 1950s to treat many diseases including septicemia, pneumonia, tuberculosis, arthritis, asthma and even poliomyelitis. The early studies were carried out by several physicians in USA and published in the American Journal of Surgery. However with the development of antibiotics, UBI use declined and it has now been called "the cure that time forgot". Later studies were mostly performed by Russian workers and in other Eastern countries and the modern view in Western countries is that UBI remains highly controversial...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29124374/complications-and-treatment-strategy-after-breast-augmentation-by-polyacrylamide-hydrogel-injection-summary-of-10-year-clinical-experience
#13
Rui Jin, Xusong Luo, Xiaoke Wang, Jie Ma, Fei Liu, Qun Yang, Jun Yang, Xi Wang
From 1997 to 2006, polyacrylamide hydrogel (PAAG) was approved for use in China as a permanent filler for breast augmentation, and it is estimated that 200,000 women have undergone PAAG injection since then. After injection, complications such as pain, mass, hematoma, asymmetry, migration, infection, and even cancer continue to emerge. Because of the potential toxicity and unstable nature of the material and the nonstandardized injection layers, complications after PAAG injection breast augmentation are often complex and difficult to treat...
November 9, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29122052/ultra-processing-an-odd-appraisal
#14
Carlos A Monteiro, Geoffrey Cannon, Jean-Claude Moubarac, Renata B Levy, Maria Laura C Louzada, Patrícia C Jaime
It is now generally agreed that the impact of the current nature, purpose and extent of food processing on human well-being, health and disease needs to be better understood and explained, in order to improve public health. The special issue of Public Health Nutrition devoted to the concept of ultra-processing of food, and the NOVA classification of which ultra-processed foods are one category, is a great step forward in this work. Coincidentally, a polemical 'critical appraisal' of ultra-processing was recently published in another journal...
November 10, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29117470/one-hundred-thousand-us-dollars-to-battle-scientific-logorrhea
#15
EDITORIAL
P B Persson
This editorial may have remained unwritten, in the face of a lifetime word cap for scientists, which is regaining interest. (Give researchers a lifetime word limit, Brian C. Martinson, Nature).Providing us with a lifespan contingent of words for our scientific writing immediately solves many present-day glitches. No more minimal-publishing-units and redundant material will flood journals or aggravate reviewers. This article is protected by copyright. All rights reserved.
November 8, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/29115962/bridging-the-human-resource-gap-in-surgical-and-anesthesia-care-in-low-resource-countries-a-review-of-the-task-sharing-literature
#16
REVIEW
Tigistu Ashengo, Alena Skeels, Elizabeth J H Hurwitz, Eric Thuo, Harshad Sanghvi
Task sharing, the involvement of non-specialists (non-physician clinicians or non-specialist physicians) in performing tasks originally reserved for surgeons and anesthesiologists, can be a potent strategy in bridging the vast human resource gap in surgery and anesthesia and bringing needed surgical care to the district level especially in low-resource countries. Although a common practice, the idea of assigning advanced tasks to less-specialized workers remains a subject of controversy. In order to optimize its benefits, it is helpful to understand the current task sharing landscape, its challenges, and its promise...
November 7, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/29111233/age-and-immunity-what-is-immunosenescence
#17
REVIEW
Graham Pawelec
As is apparent from the many contributions to this Special Issue of the Journal, the impact of age on immunity is nefarious, with all manner of dysregulated responses attributed to "immunosenescence". These range from poorer responses to vaccination, lower capacity to mediate anti-cancer responses, more inflammation and tissue damage, along with autoimmunity and loss of control of persistent infections. Given the grave clinical implications of altered immune status in aged people, it is of paramount importance to understand the nature of and mechanisms responsible for "immunosenescence"...
October 27, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29106626/pamdb-a-comprehensive-pseudomonas-aeruginosa-metabolome-database
#18
Weiliang Huang, Luke K Brewer, Jace W Jones, Angela T Nguyen, Ana Marcu, David S Wishart, Amanda G Oglesby-Sherrouse, Maureen A Kane, Angela Wilks
The Pseudomonas aeruginosaMetabolome Database (PAMDB, http://pseudomonas.umaryland.edu) is a searchable, richly annotated metabolite database specific to P. aeruginosa. P. aeruginosa is a soil organism and significant opportunistic pathogen that adapts to its environment through a versatile energy metabolism network. Furthermore, P. aeruginosa is a model organism for the study of biofilm formation, quorum sensing, and bioremediation processes, each of which are dependent on unique pathways and metabolites. The PAMDB is modelled on the Escherichia coli (ECMDB), yeast (YMDB) and human (HMDB) metabolome databases and contains >4370 metabolites and 938 pathways with links to over 1260 genes and proteins...
November 2, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29101589/the-behavioral-approach-system-bas-model-of-vulnerability-to-bipolar-disorder-evidence-of-a-continuum-in-bas-sensitivity-across-adolescence
#19
Richard T Liu, Taylor A Burke, Lyn Y Abramson, Lauren B Alloy
Behavioral Approach System (BAS) sensitivity has been implicated in the development of a variety of different psychiatric disorders. Prominent among these in the empirical literature are bipolar spectrum disorders (BSDs). Given that adolescence represents a critical developmental stage of risk for the onset of BSDs, it is important to clarify the latent structure of BAS sensitivity in this period of development. A statistical approach especially well-suited for delineating the latent structure of BAS sensitivity is taxometric analysis, which is designed to evaluate whether the latent structure of a construct is taxonic (i...
November 4, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29101442/modifications-of-z-epicanthoplasty-combined-with-double-eyelid-blepharoplasty-in-asians
#20
Shun Wu, Ke Guo, Peng Xiao, Jiaming Sun
BACKGROUND: Epicanthoplasty combined with double-eyelid blepharoplasty is one of the most popular cosmetic procedures in Asians. However, the postoperative medial canthal scar is a concerned issue. Here the authors adopted some modifications of Z-epicanthoplasty to minimize the canthal scar. METHODS: Modifications of Z-epicanthoplasty were mainly in three aspects. First, supratarsal creases were created before epicanthoplasty to prevent the impact of tension variation on epicanthal incisions, caused by elevating and tightening of the upper eyelid skin...
November 3, 2017: Aesthetic Plastic Surgery
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