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https://www.readbyqxmd.com/read/29781173/discourse-and-cognition-in-speakers-with-acquired-brain-injury-abi-a-systematic-review
#1
REVIEW
Elizabeth Hill, Mary Claessen, Anne Whitworth, Mark Boyes, Roslyn Ward
BACKGROUND: Cognitive impairment, particularly of executive functioning, has been implicated in deficits in spoken discourse production following acquired brain injury (ABI). However, due to variation in the methodologies and heterogeneity of findings across studies, the nature and extent of this association is not well understood. AIMS: This review aims to synthesize the literature investigating associations between cognitive deficits and discourse impairment after ABI...
May 20, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29776870/historical-bibliometric-analysis-of-the-top-cited-articles-on-vesicoureteral-reflux-1950-2016-and-incorporation-of-a-novel-impact-index
#2
N Fernandez, A Puerto, A Azuero, F O'Kelly, J Hannick, M Rickard, A Kirsch, A Caldamone, M Koyle
INTRODUCTION AND OBJECTIVES: Vesicoureteral reflux (VUR) has been one of the defining conditions unique to pediatric urology since its inception. The clinical implications of this disease process depend on intrinsic patient factors such as age, genetics, epigenetics, voiding habits, anatomic anomalies, and extrinsic factors such as the pathogenicity of infectious agents. Knowledge about its natural history, the implications of conservative and surgical management, and their associated outcomes have evolved dramatically over time...
April 24, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29775468/conflicts-of-interest-of-editors-of-medical-journals
#3
Waqas Haque, Abu Minhajuddin, Arjun Gupta, Deepak Agrawal
BACKGROUND: Almost all medical journals now require authors to publicly disclose conflicts of interests (COI). The same standard and scrutiny is rarely employed for the editors of the journals although COI may affect editorial decisions. METHODS: We conducted a retrospective observational study to determine the prevalence and magnitude of financial relationships among editors of 60 influential US medical journals (10 each for internal medicine and five subspecialties: cardiology, gastroenterology, neurology, dermatology and allergy & immunology)...
2018: PloS One
https://www.readbyqxmd.com/read/29772963/simplifying-skin-disease-diagnosis-with-topical-nanotechnology
#4
David C Yeo, Chenjie Xu
A new study published in the journal Nature Biomedical Engineering1 documents a novel diagnostic technology that exploits topically applied nanotechnology to detect skin tissue biomarkers for diagnosis. This concept is demonstrated by noninvasively imaging connective tissue growth factor (CTGF) mRNA in abnormal scar cells, whole tissue, and animal models. In this commentary, we highlight the main findings and discuss their implications. Successful implementation in the clinic could give rise to self-applied, biopsy-free diagnostic technology and significantly reduce healthcare burden...
May 1, 2018: SLAS Technology
https://www.readbyqxmd.com/read/29771986/correction-the-natural-compound-jatrophone-interferes-with-wnt-%C3%AE-catenin-signaling-and-inhibits-proliferation-and-emt-in-human-triple-negative-breast-cancer
#5
Iram Fatima, Ikbale El-Ayachi, Ling Taotao, M Angeles Lillo, Raisa I Krutilina, Tiffany N Seagroves, Tomasz W Radaszkiewicz, Miroslav Hutnan, Vitezslav Bryja, Susan A Krum, Fatima Rivas, Gustavo A Miranda-Carboni
[This corrects the article DOI: 10.1371/journal.pone.0189864.].
2018: PloS One
https://www.readbyqxmd.com/read/29768137/organic-amendments-beneficial-microbes-and-soil-microbiota-toward-a-unified-framework-for-disease-suppression
#6
Giuliano Bonanomi, Matteo Lorito, Francesco Vinale, Sheridan L Woo
Organic amendments (OAs) and soilborne biocontrol agents or beneficial microbes (BMs) have been extensively studied and applied worldwide in most agriculturally important plant species. However, poor integration of research and technical approaches has limited the development of effective disease management practices based on the combination of these two bio-based strategies. Insights into the importance of the plant-associated microbiome for crop productivity, which can be modified or modulated by introducing OAs and/or BMs, are providing novel opportunities to achieve the goal of long-term disease control...
May 16, 2018: Annual Review of Phytopathology
https://www.readbyqxmd.com/read/29764456/a-scoping-review-of-reporting-ethical-research-practices-in-research-conducted-among-refugees-and-war-affected-populations-in-the-arab-world
#7
Jihad Makhoul, Rana F Chehab, Zahraa Shaito, Abla M Sibai
BACKGROUND: Ethical research conduct is a cornerstone of research practice particularly when research participants include vulnerable populations. This study mapped the extent of reporting ethical research practices in studies conducted among refugees and war-affected populations in the Arab World, and assessed variations by time, country of study, and study characteristics. METHODS: An electronic search of eight databases resulted in 5668 unique records published between 2000 and 2013...
May 15, 2018: BMC Medical Ethics
https://www.readbyqxmd.com/read/29763472/p-values-in-display-items-are-ubiquitous-and-almost-invariably-significant-a-survey-of-top-science-journals
#8
Ioana Alina Cristea, John P A Ioannidis
P values represent a widely used, but pervasively misunderstood and fiercely contested method of scientific inference. Display items, such as figures and tables, often containing the main results, are an important source of P values. We conducted a survey comparing the overall use of P values and the occurrence of significant P values in display items of a sample of articles in the three top multidisciplinary journals (Nature, Science, PNAS) in 2017 and, respectively, in 1997. We also examined the reporting of multiplicity corrections and its potential influence on the proportion of statistically significant P values...
2018: PloS One
https://www.readbyqxmd.com/read/29739337/colliding-ideals-an-interview-study-of-how-intervention-researchers-address-adherence-and-adaptations-in-replication-studies
#9
Ulrica von Thiele Schwarz, Ulrika Förberg, Knut Sundell, Henna Hasson
BACKGROUND: For an intervention to be considered evidence-based, findings need to be replicated. When this is done in new contexts (e.g., a new country), adaptations may be needed. Yet, we know little about how researchers approach this. This study aims to explore how researchers reason about adaptations and adherence when conducting replication studies, describe what adaptations they make and how these are reported in scientific journals. METHODS: This was an interview study conducted in 2014 with principal investigators of Swedish replication studies reporting adaptations to an intervention from another country...
May 8, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29728819/the-changing-tides-of-irish-orthopaedic-research
#10
Ailbhe White Gibson, Kevin Clesham, Oisin Tully, John F Quinlan
INTRODUCTION: Research is fundamental to bridging theory, practice and education in orthopaedics. Following the restructuring of the surgical training pathway in Ireland, the opportunity to undertake clinical- or lab-based research has fallen. AIMS: Our aim was to investigate the trends of research in orthopaedics and the implications there. METHODS: We reviewed the trend in publications by Irish trauma and orthopaedic (T&O) trainees over the past 20 years across three different classes of journal...
May 4, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29727582/along-the-central-dogma-controlling-gene-expression-with-small-molecules
#11
Tilman Schneider-Poetsch, Minoru Yoshida
The central dogma of molecular biology, that DNA is transcribed into RNA and RNA translated into protein, was coined in the early days of modern biology. Back in the 1950s and 1960s, bacterial genetics first opened the way toward understanding life as the genetically encoded interaction of macromolecules. As molecular biology progressed and our knowledge of gene control deepened, it became increasingly clear that expression relied on many more levels of regulation. In the process of dissecting mechanisms of gene expression, specific small-molecule inhibitors played an important role and became valuable tools of investigation...
May 4, 2018: Annual Review of Biochemistry
https://www.readbyqxmd.com/read/29724409/the-use-of-solicited-publishing-by-academic-surgeons
#12
Vi Nguyen, Rebecca A Marmor, Sonia L Ramamoorthy, Todd W Costantini, Joel M Baumgartner, Jennifer Berumen, Garth R Jacobsen, Jason K Sicklick
BACKGROUND: Few details are known about open-access surgery journals that solicit manuscripts via E-mail. The objectives of this cross-sectional study are to compare solicitant surgery journals with established journals and to characterize the academic credentials and reasons for publication of their authorship. METHODS: We identified publishers who contacted the senior author and compared their surgery journals with 10 top-tier surgical journals and open-access medical journals...
April 30, 2018: Surgery
https://www.readbyqxmd.com/read/29720640/nature-journals-formalize-ethical-standards-for-human-embryo-and-stem-cell-research
#13
(no author information available yet)
No abstract text is available yet for this article.
May 2018: Nature
https://www.readbyqxmd.com/read/29719077/a-scoping-review-of-studies-exploring-physical-activity-among-adolescents-and-young-adults-diagnosed-with-cancer
#14
REVIEW
Jennifer Brunet, Amanda Wurz, Shirin M Shallwani
OBJECTIVE: Physical activity can improve health, functional capacity, and quality of life in children and adults with cancer. Physical activity may also offer important benefits to adolescents and young adults diagnosed with cancer (AYAs). We conducted a scoping review to determine the extent, range, and nature of published studies on physical activity among AYAs, identify knowledge gaps, and provide directions for future research. METHODS: We searched four electronic databases for published studies...
May 2, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29718995/correction-inhibiting-tgf-beta-signaling-preserves-the-function-of-highly-activated-in-vitro-expanded-natural-killer-cells-in-aml-and-colon-cancer-models
#15
Folashade Otegbeye, Evelyn Ojo, Stephen Moreton, Nathan Mackowski, Dean A Lee, Marcos de Lima, David N Wald
[This corrects the article DOI: 10.1371/journal.pone.0191358.].
2018: PloS One
https://www.readbyqxmd.com/read/29717699/self-management-education-for-adults-with-poorly-controlled-epilepsy-smile-uk-a-randomised-controlled-trial
#16
Leone Ridsdale, Alison McKinlay, Gabriella Wojewodka, Emily J Robinson, Iris Mosweu, Sarah J Feehan, Adam J Noble, Myfanwy Morgan, Stephanie Jc Taylor, Paul McCrone, Sabine Landau, Mark Richardson, Gus Baker, Laura H Goldstein
BACKGROUND: Epilepsy is a common neurological condition resulting in recurrent seizures. Research evidence in long-term conditions suggests that patients benefit from self-management education and that this may improve quality of life (QoL). Epilepsy self-management education has yet to be tested in a UK setting. OBJECTIVES: To determine the effectiveness and cost-effectiveness of Self-Management education for people with poorly controlled epILEpsy [SMILE (UK)]...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29717685/a-bibliometric-profile-of-disaster-medicine-research-from-2008-to-2017-a-scientometric-analysis
#17
Liang Zhou, Ping Zhang, Zhigang Zhang, Lidong Fan, Shuo Tang, Kunpeng Hu, Nan Xiao, Shuguang Li
ABSTRACTThis study analyzed and assessed publication trends in articles on "disaster medicine," using scientometric analysis. Data were obtained from the Web of Science Core Collection (WoSCC) of Thomson Reuters on March 27, 2017. A total of 564 publications on disaster medicine were identified. There was a mild increase in the number of articles on disaster medicine from 2008 (n=55) to 2016 (n=83). Disaster Medicine and Public Health Preparedness published the most articles, the majority of articles were published in the United States, and the leading institute was Tohoku University...
May 2, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29709861/ambient-air-quality-and-exposure-assessment-study-of-the-gulf-cooperation-council-countries-a-critical-review
#18
REVIEW
Hamid Omidvarborna, Mahad Baawain, Abdullah Al-Mamun
With rapid urbanization and economic growth, many developing countries have faced a greater share of air pollutants in recent years. An increasing number of exposure studies on air pollutants have been reported lately. However, due to lack of strict regulations and monitoring stations among developing countries, such as Gulf Cooperation Council (GCC) countries, limited air pollution and exposure assessment studies have been conducted in this region. Thus, the objective of this critical review was to identify the major sources of air pollutants in the region with hot and arid/semiarid climate for the main categories contributing to specific pollutants...
April 27, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29709207/viral-strategies-for-targeting-the-central-and-peripheral-nervous-systems
#19
Claire N Bedbrook, Benjamin E Deverman, Viviana Gradinaru
Recombinant viruses allow for targeted transgene expression in specific cell populations throughout the nervous system. The adeno-associated virus (AAV) is among the most commonly used viruses for neuroscience research. Recombinant AAVs (rAAVs) are highly versatile and can package most cargo composed of desired genes within the capsid's ∼5-kb carrying capacity. Numerous regulatory elements and intersectional strategies have been validated in rAAVs to enable cell type-specific expression. rAAVs can be delivered to specific neuronal populations or globally throughout the animal...
April 25, 2018: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/29709204/ancient-human-genomics-the-first-decade
#20
Pontus Skoglund, Iain Mathieson
The first decade of ancient genomics has revolutionized the study of human prehistory and evolution. We review new insights based on prehistoric human genomes, including greatly increased resolution of the timing and structure of the out-of-Africa event, the diversification of present-day non- African populations, and the earliest expansions of those populations into Eurasia and America. Prehistoric genomes now document patterns of population transformation on every inhabited continent-in particular the effect of agricultural expansions in Africa, Europe, and Oceania-and record a history of natural selection that shapes present-day phenotypic diversity...
April 25, 2018: Annual Review of Genomics and Human Genetics
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